PRPF8

General Information

Gene Name       : PRPF8
Gene ID             : ENSG00000174231.16
Essential Gene : Yes

Functions

Localization(RBPImage: PRPF8)

Domains (AlphaFold: PRPF8)


Antibody Validation

 View validation images for all PRPF8 antibodies

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878PRPF8ENSG00000174231.16121.53154.19137.86ENCSR000AEF
HepG2PRPF8ENSG00000174231.16219.76146.84183.30ENCSR985KAT
K562PRPF8ENSG00000174231.16150.31150.57150.44ENCSR000AEO

Assays

5 Released experiments are available on ENCORE database.

Assay TypeExp_NameENCODE IDTarget labelBiosampleStatusLinked AntibodyControlsMethodNote
eCLIPeCLIP: 278ENCSR534YOIPRPF8K562ReleasedENCAB207WICENCSR096SZE  
eCLIPeCLIP: 291ENCSR121NVAPRPF8HepG2ReleasedENCAB207WICENCSR565KBR  
knockdown followed by RNA-seq PRPF8-BGKLV19-K562ENCSR137HKSPRPF8K562ReleasedENCSR661HEL   shRNAKD% = ,
knockdown followed by RNA-seq PRPF8-BGHLV17-HepG2ENCSR998MZPPRPF8HepG2ReleasedENCSR856ZRV   shRNAKD% = 84.1,90.1
knockdown followed by RNA-seq PRPF8-BGKcLV08-K562ENCSR320IEKPRPF8K562ReleasedENCSR015KGT   CRISPRKD% = 62.4,66.2






  eCLIP  
  RBP    Exp_UID    Cell_Line    ENCODE_ACCESSION    Control_ENCODE_ACCESSION    ENCODE_Antibody_ID    Antibody    Lot_num    Status    Project  
PRPF8278K562ENCSR534YOIENCSR096SZEENCAB207WICA303-921A1ReleasedENCODE3
PRPF8291HepG2ENCSR121NVAENCSR565KBRENCAB207WICA303-921A1ReleasedENCODE3


  Antibody Validation  
  GeneName    Antibody_DCC_ID    Product_ID    Lot_ID    Phosphate    HepG2 Primary Validation    K562 Primary Validation    HepG2 Secondary Validation    K562 Secondary Validation  
PRPF8ENCAB207WICA303-921A1Released, ENCODE3Released, ENCODE3BGHLV17-23, Released, ENCODE3BGKcLV08-51, Released, ENCODE4
PRPF8ENCAB100KQSRN094PW1Released, ENCODE3Released, ENCODE3BGKcLV08-51, Released, ENCODE4


  KD RNA-Seq  
  GeneName    Cell_Line    Method    Exp_ID    Control_ID    Sample_reps    Control_reps    KD%    Status    Project    Note  
PRPF8K562shRNAENCSR137HKSENCSR661HELPRPF8_BGKLV19_43B,PRPF8_BGKLV19_44BNT_BGKLV19_1B,NT_BGKLV19_2B,ReleasedENCODE3
PRPF8HepG2shRNABGHLV16-43,BGHLV16-44BGHLV16-1,BGHLV16-2NotSatisfiedENCODE3
PRPF8HepG2shRNAENCSR998MZPENCSR856ZRVPRPF8_BGHLV17_23,PRPF8_BGHLV17_24NT_BGHLV17_63,NT_BGHLV17_6484.1,90.1ReleasedENCODE3
PRPF8K562CRISPRENCSR320IEKENCSR015KGTPRPF8-BGKcLV08-51,PRPF8-BGKcLV08-52NT-BGKcLV08-1,NT-BGKcLV08-262.4,66.2ReleasedENCODE4
PRPF8K562CRISPRBGKcLV08-53,BGKcLV08-54BGKcLV08-1,BGKcLV08-249.9,36.4NotSatisfiedENCODE4


  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  
    PRPF8: Click to RBP Image Database
  • Nuclei
  • Mutually Exclusive from Nucleolus
  • Speckles
  • Cytoplasm
  • Cytosolic
  • Nuclear release mitosis












    • RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela
    PRPF8Product_ID: A303-921A
    Lot_ID: 1
    Source: Bethyl Labs
    Target Name: PRPF8-human    		 HepG2_Bethyl_303-921A_1_PRPF8.png<br>Caption: IP-Western Blot analysis of HepG2 whole cell lysate using PRPF8 specific antibody. Lane 1 is 1% of twenty million whole cell lysate input and lane 2 is 25% of IP enrichment using rabbit normal IgG (lanes under 'IgG'). Lane 3 is 1% of twenty million whole cell lysate input and lane 4 is 10% IP enrichment using rabbit polyclonal anti-PRPF8 antibody (lanes under 'PRPF8').
    		 PRPF8_Secondary_Western.png<br>Caption: Western blot following shRNA against PRPF8 in HepG2 whole cell lysate using PRPF8 specific antibody. Lane 1 is a ladder, lane 2 is HepG2 non-targeting control knockdown, lane 3 and 4 are two different shRNAs against PRPF8. PRPF8 protein appears as the green band, Tubulin serves as a control and appears in red.
    		 K562_Bethyl_A303-921A_1_PRPF8.png<br>Caption: IP-Western Blot analysis of K562 whole cell lysate using PRPF8 specific antibody. Lane 1 is 1% of twenty million whole cell lysate input and lane 2 is 25% of IP enrichment using rabbit normal IgG (lanes under 'IgG'). Lane 3 is 1% of twenty million whole cell lysate input and lane 4 is 10% IP enrichment using rabbit polyclonal anti-PRPF8 antibody (lanes under 'PRPF8').
    		 PRPF8-K562-CRISPR.png<br>Caption: Western blot following CRISPR against PRPF8 in K562 whole cell lysate using PRPF8 specific antibody. Lane 1 is a ladder, lane 2 is K562 non-targeting control knockdown, lane 3 and 4 are two different CRISPR against PRPF8.PRPF8 protein appears as the green band, Tubulin serves as a control and appears in red.
    PRPF8Product_ID: RN094PW
    Lot_ID: 1
    Source: MBLI
    Target Name: PRPF8-human    		 PRPF8_HepG2.png<br>Caption: IP-Western Blot analysis of HepG2 whole cell lysate using PRPF8 specific antibody. Lane 1 is 3% of ten million whole cell lysate input (lane under '10% input') , lane 2 is 30% of IP enrichment using rabbit normal IgG (lane under 'IgG') and lane 3 is 30% IP enrichment using rabbit monoclonal anti-PRPF8 antibody (lanes under 'anti-PRPF8'). Asterisk indicates non-specific band. Conformation specific secondary antibody (Cell Signaling Technology, #5127) was used for western blot.








    RNA Targets
    • PRPF8 protein binds to 30,893 RNA regions.  





    Proteins bound to RNA
    • PRPF8 RNA is bound by 45 proteins.  






    PRPF8 protein has 30,893 RNA targets:

    Only display 100 entries as example. Please click "View All" button to see all 30,893 entries.     

    RBP Chr Start End Strand log2(fold change) -log(p-value) Cell Line Matched Gene Matched Area
    PRPF8chr11134131783134131897+5.286016.69228HepG2ACAD83'-UTR,CDS,intron-Distal,intron-Proximal
    PRPF8chr1110555159110555200+4.288113.12843K562AHCYL1intron-Distal,intron-Proximal
    PRPF8chr116155139461551407+3.797846.55814HepG2MYRFCDS,intron-Proximal
    PRPF8chr193550023135500280+3.8180811.26073HepG2GRAMD1A5'-UTR,CDS,intron-Proximal
    PRPF8chr206077301160773076+3.738669.09021HepG2MTG23'-UTR,CDS,intron-Distal,intron-Proximal
    PRPF8chr8144886174144886222-4.159257.26133HepG2SCRIBCDS,intron-Distal,intron-Proximal
    PRPF8chr195560377755603810-3.257136.74268HepG2PPP1R12Cintron-Distal,intron-Proximal
    PRPF8chr1167734959167735029+4.315226.95612HepG2MPZL1CDS,intron-Proximal
    PRPF8chr125822318858223240-3.733476.69747HepG2CTDSP23'-UTR,CDS,intron-Distal,intron-Proximal
    PRPF8chr175658209956582159-4.002429.08333HepG2MTMR4CDS,intron-Distal,intron-Proximal
    PRPF8chr74460767144607719-3.6611010.59198HepG2DDX563'-UTR,CDS,intron-Distal,intron-Proximal
    PRPF8chr162898682528986916+3.299017.09156HepG2RP11-264B17.3, SPNS1CDS,intron-Distal,intron-Proximal
    PRPF8chr203431707734317117-3.320204.98422K562RBM39intron-Distal
    PRPF8chr76555430965554353+3.4420610.89299HepG2AC068533.7, ASLCDS,intron-Distal,intron-Proximal
    PRPF8chr193312226633122343-4.562425.05356HepG2ANKRD27CDS,intron-Distal,intron-Proximal
    PRPF8chr177438205174382114+3.3884966.62943HepG2SPHK1CDS,intron-Proximal
    PRPF8chr35391061753910671-4.541813.56873HepG2ACTR8CDS,intron-Distal,intron-Proximal
    PRPF8chr114600118446001327-3.236704.21588K562PHF21A3'-UTR,CDS,intron-Distal,intron-Proximal
    PRPF8chr1197055885197055925-3.930984.58287K562ASPMintron-Distal,intron-Proximal
    PRPF8chr22123598521236014-4.8641525.52126HepG2APOBintron-Distal,intron-Proximal
    PRPF8chr2152303060152303127+5.940095.01842HepG2RIF1CDS,intron-Proximal
    PRPF8chr176228989462289948-5.040763.70131HepG2TEX2CDS,intron-Distal,intron-Proximal
    PRPF8chr11117109940117109988+3.796644.93376K562RNF214intron-Distal
    PRPF8chr33843864338438682+4.016996.04280HepG2XYLB3'-UTR,CDS,intron-Proximal
    PRPF8chr10135101588135101619-4.250029.68077HepG2TUBGCP2intron-Distal,intron-Proximal
    PRPF8chr513389141338976-4.6654411.25775HepG2CLPTM1LCDS,intron-Distal,intron-Proximal
    PRPF8chr162367255623672653+4.559376.18341HepG2DCTN53'-UTR,CDS,intron-Proximal
    PRPF8chr9139732467139732511+5.513028.04585HepG2RABL6intron-Distal,intron-Proximal
    PRPF8chr1230314029230314095+4.088365.93840HepG2GALNT2CDS,intron-Distal,intron-Proximal
    PRPF8chr3179069915179069995+4.073683.31283K562MFN1intron-Distal,intron-Proximal
    PRPF8chr222692412126924231-6.3400212.49766HepG2TPST23'-UTR,CDS,intron-Distal,intron-Proximal
    PRPF8chr168996717989967261+3.2698524.30909HepG2TCF25CDS,intron-Proximal
    PRPF8chr27475621174756238-3.6123780.68846HepG2AUP1intron-Distal,intron-Proximal
    PRPF8chrX135961044135961069-4.1673314.86752K562RBMXintron-Distal
    PRPF8chr10135107052135107070-4.572513.37645HepG2TUBGCP2CDS,intron-Distal,intron-Proximal
    PRPF8chr79583808795838182-4.5058512.21138HepG2SLC25A133'-UTR,CDS,intron-Distal,intron-Proximal
    PRPF8chr5176950912176950963-3.124456.02950HepG2FAM193B3'-UTR,CDS,intron-Distal,intron-Proximal
    PRPF8chr174336655443366623-3.231074.78164HepG2MAP3K14intron-Distal,intron-Proximal
    PRPF8chr51448137114481433+4.472744.75655HepG2TRIOCDS,intron-Proximal
    PRPF8chr63165604331656122-3.4743814.21790K562ABHD16A, XXbac-BPG32J3.203'-UTR,CDS,intron-Distal,intron-Proximal
    PRPF8chr99602628496026361+3.405917.89388HepG2WNK23'-UTR,CDS,intron-Proximal
    PRPF8chr21565130115651368-3.633025.90285HepG2NBASCDS,intron-Distal,intron-Proximal
    PRPF8chr25488234054882354+3.499725.05395HepG2SPTBN1CDS,intron-Proximal
    PRPF8chr191945571619455782+3.015145.23086K562MAU2CDS,intron-Proximal
    PRPF8chr26326592463265992+3.5475023.99835HepG2EHBP1CDS,intron-Proximal
    PRPF8chr223971266839712698-3.281203.96605K562RPL3intron-Distal,intron-Proximal
    PRPF8chr13607072336070799-4.591955.33214K562PSMB2intron-Distal,intron-Proximal
    PRPF8chr2224744808224744888-4.328467.56654HepG2WDFY1CDS,intron-Distal,intron-Proximal
    PRPF8chr35391120253911264-5.230264.02817HepG2ACTR85'-UTR,CDS,intron-Distal,intron-Proximal
    PRPF8chr193488733034887380+4.148516.81564HepG2RP11-618P17.4, GPICDS,intron-Proximal
    PRPF8chr10104492650104492704+5.025967.46483HepG2SFXN23'-UTR,CDS,intron-Proximal
    PRPF8chrX7076444670764477+3.1081313.60922HepG2OGTCDS
    PRPF8chr123449702345062-5.6395512.77088HepG2PEX105'-UTR,intron-Distal
    PRPF8chr1977092667709304+3.788119.48220K562STXBP2intron-Distal
    PRPF8chr715131611513209-3.022745.76569HepG2INTS1CDS,intron-Distal,intron-Proximal
    PRPF8chr1892117879211820+4.888926.15361K562RP11-21J18.1, ANKRD12intron-Distal,intron-Proximal
    PRPF8chr1749054044905499+5.2477641.24400HepG2KIF1CCDS,intron-Proximal
    PRPF8chr174258061642580724-6.2680815.65693K562GPATCH85'-UTR,CDS,intron-Distal
    PRPF8chr174862746648627486+6.225828.04585HepG2SPATA203'-UTR,5'-UTR,CDS,intron-Proximal
    PRPF8chr31505526615055351+3.8798611.57027HepG2NR2C2CDS,intron-Proximal
    PRPF8chr174228862142288681-4.581477.46483HepG2UBTFCDS,intron-Distal,intron-Proximal
    PRPF8chr12112846143112846247-4.8773927.30359HepG2RPL6CDS,intron-Distal,intron-Proximal
    PRPF8chr177997748079977523-3.373847.83206HepG2STRA13CDS,intron-Distal,intron-Proximal
    PRPF8chr4146019531146019616+6.3272913.18741HepG2ABCE15'-UTR,intron-Proximal
    PRPF8chr9124522697124522763+3.1261113.11089HepG2DAB2IPCDS,intron-Proximal
    PRPF8chr159148597391486029+3.712105.25185K562UNC45Aintron-Distal
    PRPF8chr103210315832103258-5.784526.35567HepG2ARHGAP12CDS,intron-Distal,intron-Proximal
    PRPF8chrX1894243718942516-4.5143413.80141HepG2PHKA2CDS,intron-Distal,intron-Proximal
    PRPF8chr172705228127052372-5.180265.68502HepG2TLCD1CDS,intron-Distal,intron-Proximal
    PRPF8chr145542900655429085-3.238343.18246K562WDHD1intron-Distal
    PRPF8chr79962759199627616+4.5958520.15752HepG2ZKSCAN1intron-Proximal
    PRPF8chr4667055667093-5.204038.38577HepG2ATP5ICDS,intron-Distal,intron-Proximal
    PRPF8chr27459414674594218-4.5137616.04525HepG2DCTN1CDS,intron-Distal,intron-Proximal
    PRPF8chr9134106164134106192+4.269846.35873K562NUP214intron-Proximal
    PRPF8chr177471640474716456-3.761776.65114HepG2JMJD63'-UTR,CDS,intron-Distal,intron-Proximal
    PRPF8chr12208289622082970-3.0384914.84500K562USP48intron-Distal,intron-Proximal
    PRPF8chr1155033934155034019+4.039364.93376K562ADAM15CDS,intron-Distal,intron-Proximal
    PRPF8chr13845512238455207-3.9127212.74800K562SF3A3intron-Distal,intron-Proximal
    PRPF8chr76631362766313688+4.5612920.92431HepG2RP11-458F8.1intron-Distal,intron-Proximal
    PRPF8chr125467612954676143+5.8306211.79381K562RP11-968A15.8, HNRNPA1intron-Distal,intron-Proximal
    PRPF8chr203079536130795455-3.815228.96944HepG2PLAGL25'-UTR,intron-Distal
    PRPF8chr175608311656083173-3.6605211.20046HepG2SRSF13'-UTR,CDS,intron-Distal,intron-Proximal
    PRPF8chr135299204252992182-3.627143.88924K562VPS36CDS,intron-Distal,intron-Proximal
    PRPF8chr34771212947712184-4.044945.34978HepG2SMARCC1CDS,intron-Distal,intron-Proximal
    PRPF8chr105173281251732903+4.156489.08333HepG2LINC00843intron-Proximal
    PRPF8chr1648169774817057-5.072514.35676HepG2ZNF5005'-UTR,intron-Distal,intron-Proximal
    PRPF8chr107476945974769507-4.069054.95247K562P4HA1intron-Distal,intron-Proximal
    PRPF8chr12221096422210981-4.223463.85435K562HSPG2intron-Distal,intron-Proximal
    PRPF8chr118572198285722069-4.2615524.06871K562PICALMintron-Distal,intron-Proximal
    PRPF8chr204457579544575846+5.268678.38577HepG2PCIF1CDS,intron-Proximal
    PRPF8chr162896586528965920+3.9687713.56463HepG2NFATC2IPCDS,intron-Distal,intron-Proximal
    PRPF8chr4164438612164438679+3.042984.63797K562TMA163'-UTR,CDS,intron-Distal,intron-Proximal
    PRPF8chr9102864106102864219+4.876886.45599K562INVSintron-Distal
    PRPF8chr12890798428908058-4.1778916.68897K562SNHG12intron-Distal
    PRPF8chr191896584018965860+3.564965.34140HepG2UPF1CDS,intron-Proximal
    PRPF8chr22914585529145927+3.408084.64824K562WDR43intron-Proximal
    PRPF8chr177965860179658638+3.278106.67352HepG2HGSintron-Proximal
    PRPF8chr115758294057583013+4.1217615.18162HepG2CTNND13'-UTR,CDS,intron-Proximal
    PRPF8chr124676627746766289-3.4197824.27383HepG2SLC38A2intron-Distal,intron-Proximal
    PRPF8chr1212236314212236393+3.271904.48980K562DTLintron-Distal,intron-Proximal




    45 proteins are bound to PRPF8 RNA:

    Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
    chr1715539521554012-3'-UTR,CDS,intron-Distal3.007309.51589HepG2LARP4
    chr1715540261554136-3'-UTR,CDS,intron-Distal,intron-Proximal3.6846021.63021K562PCBP1
    chr1715539431553994-3'-UTR,CDS,intron-Distal3.8221313.98884K562PABPC4
    chr1715539611554021-3'-UTR,CDS,intron-Distal3.241766.27613K562NOLC1
    chr1715539521554006-3'-UTR,CDS,intron-Distal3.084475.78920K562APOBEC3C
    chr1715540441554103-3'-UTR,CDS,intron-Distal,intron-Proximal3.884057.39763HepG2PCBP1
    chr1715540871554130-3'-UTR,CDS,intron-Distal,intron-Proximal3.133786.85927K562FMR1
    chr1715539531554023-3'-UTR,CDS,intron-Distal4.8405736.86487HepG2SUB1
    chr1715880651588111-5'-UTR,intron-Distal,intron-Proximal3.323535.26725HepG2DDX3X
    chr1715880181588079-5'-UTR,intron-Distal4.163765.56912HepG2AQR
    chr1715881051588152-5'-UTR,intron-Distal,intron-Proximal4.937635.47892K562DDX3X
    chr1715878531587906-5'-UTR,CDS,intron-Distal,intron-Proximal4.596846.48405K562AQR
    chr1715880731588122-5'-UTR,intron-Distal,intron-Proximal5.6238426.59140K562FXR2
    chr1715878991587931-5'-UTR,intron-Distal,intron-Proximal3.444404.09623HepG2SF3B4
    chr1715879981588086-5'-UTR,intron-Distal5.2795710.08262K562AQR
    chr1715879361587999-5'-UTR,intron-Distal,intron-Proximal5.420585.58842K562EFTUD2
    chr1715880731588094-5'-UTR,intron-Distal4.182329.84721K562FMR1
    chr1715880721588105-5'-UTR,intron-Distal,intron-Proximal3.476085.03702K562DDX3X
    chr1715880941588153-5'-UTR,intron-Distal,intron-Proximal5.0951617.24176K562FMR1
    chr1715879321588062-5'-UTR,intron-Distal,intron-Proximal4.2742913.00591HepG2EFTUD2
    chr1715878571587876-5'-UTR,CDS,intron-Distal6.2971117.91138K562FXR2
    chr1715877651587877-5'-UTR,CDS,intron-Distal,intron-Proximal3.5837223.31607K562DDX3X
    chr1715649261564937-CDS,intron-Distal4.6223610.34406K562LIN28B
    chr1715768421576861-CDS,intron-Distal4.186817.63447K562FMR1
    chr1715649361564992-CDS,intron-Distal4.932646.56854K562FXR1
    chr1715808601580899-CDS,intron-Distal4.4988718.76597K562FMR1
    chr1715795491579606-CDS,intron-Distal,intron-Proximal3.281529.60267HepG2G3BP1
    chr1715652611565277-CDS,intron-Distal4.6735620.74915K562FXR2
    chr1715799801580005-CDS,intron-Distal6.2221015.80431K562FXR2
    chr1715784571578564-CDS,intron-Distal3.5499417.44344HepG2G3BP1
    chr1715771581577214-CDS,intron-Distal,intron-Proximal4.0010720.36659K562AQR
    chr1715784581578558-CDS,intron-Distal3.814156.92158K562FXR1
    chr1715568711556939-CDS,intron-Distal3.242073.26004K562PUM1
    chr1715649031564913-CDS,intron-Distal,intron-Proximal4.0248814.19863HepG2LIN28B
    chr1715619791562027-CDS,intron-Distal5.7090123.63189K562FXR2
    chr1715798811579912-CDS,intron-Distal4.4063914.09690K562FXR2
    chr1715868921586986-CDS,intron-Distal3.5188814.04778HepG2GRWD1
    chr1715855071585587-CDS,intron-Distal3.704418.43905HepG2PPIG
    chr1715784491578583-CDS,intron-Distal3.3897913.69572HepG2FXR2
    chr1715544021554481-CDS,intron-Distal3.7412310.35086HepG2DDX55
    chr1715627141562764-CDS,intron-Distal,intron-Proximal3.7359719.72718K562FMR1
    chr1715797981579830-CDS,intron-Distal,intron-Proximal3.389505.10345K562METAP2
    chr1715868931586958-CDS,intron-Distal4.113303.22063K562TRA2A
    chr1715766721576691-CDS,intron-Distal3.8380612.79105K562FMR1
    chr1715841001584175-CDS,intron-Distal,intron-Proximal3.197505.09479K562SF3B4
    chr1715640831564152-CDS,intron-Distal,intron-Proximal3.1737710.98201K562SF3B4
    chr1715826501582700-CDS,intron-Distal,intron-Proximal4.1939117.43721K562RPS3
    chr1715649091564913-CDS,intron-Distal4.490588.89719K562FXR2
    chr1715644121564445-CDS,intron-Distal4.327094.67478K562FXR1
    chr1715786311578700-CDS,intron-Distal,intron-Proximal3.252233.13970HepG2SF3B4
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    chr1715631081563173-CDS,intron-Distal,intron-Proximal3.693855.38772K562RBM15
    chr1715647221564769-intron-Distal,intron-Proximal4.155404.48843K562TIA1
    chr1715788611578897-intron-Distal,intron-Proximal5.056306.69228HepG2PRPF8
    chr1715628481562912-intron-Distal,intron-Proximal4.720047.09251K562TIA1
    chr1715630111563079-intron-Distal,intron-Proximal4.512856.01372K562AQR
    chr1715802081580270-intron-Distal,intron-Proximal5.247596.83960K562AQR
    chr1715832921583358-intron-Distal4.465673.29197K562HNRNPM
    chr1715867431586792-intron-Distal,intron-Proximal5.050814.24111K562EFTUD2
    chr1715807541580846-intron-Distal,intron-Proximal3.981026.42586K562TIA1
    chr1715629961563096-intron-Distal,intron-Proximal3.299455.83808K562U2AF2
    chr1715820111582044-intron-Distal,intron-Proximal4.892519.43475HepG2PRPF8
    chr1715876991587763-intron-Distal,intron-Proximal3.807823.96535HepG2AQR
    chr1715867451586773-intron-Distal,intron-Proximal3.166464.87883K562BUD13
    chr1715876451587715-intron-Distal,intron-Proximal3.893288.82330HepG2EFTUD2
    chr1715866201586674-intron-Distal3.644925.21358K562TIA1
    chr1715817321581789-intron-Distal,intron-Proximal3.849796.87998K562TIA1
    chr1715630081563090-intron-Distal,intron-Proximal5.8323012.07006HepG2U2AF2
    chr1715641521564225-intron-Distal,intron-Proximal5.7447126.70801K562SF3B4
    chr1715650891565102-intron-Distal,intron-Proximal3.626586.43870K562U2AF2
    chr1715796741579753-intron-Distal,intron-Proximal5.754989.62108K562SF3B4
    chr1715876691587709-intron-Distal,intron-Proximal4.461815.32062K562EFTUD2
    chr1715567911556835-intron-Distal,intron-Proximal3.834485.35619K562AQR
    chr1715797451579790-intron-Distal,intron-Proximal4.133203.39593HepG2PRPF4
    chr1715867311586798-intron-Distal,intron-Proximal4.2472811.71462K562PRPF8
    chr1715631251563135-intron-Distal,intron-Proximal4.001076.69182K562AQR
    chr1715766051576650-intron-Distal,intron-Proximal3.226225.84601HepG2PRPF8
    chr1715776421577731-intron-Distal,intron-Proximal6.2182815.81095K562PRPF8
    chr1715786811578710-intron-Distal,intron-Proximal4.994807.02609K562UCHL5
    chr1715856421585708-intron-Distal,intron-Proximal3.402615.89182K562EFTUD2
    chr1715630881563125-intron-Distal,intron-Proximal4.3492310.08968K562AQR
    chr1715772141577253-intron-Distal,intron-Proximal3.734828.13013K562AQR
    chr1715638941563931-intron-Distal,intron-Proximal4.060563.74254HepG2SF3B4
    chr1715763371576373-intron-Distal,intron-Proximal4.556304.68690HepG2PRPF8
    chr1715817351581782-intron-Distal,intron-Proximal4.068744.37625HepG2RBM22
    chr1715797071579748-intron-Distal,intron-Proximal4.466294.92499HepG2AQR
    chr1715616781561727-intron-Distal,intron-Proximal4.004255.85206K562EFTUD2
    chr1715647251564746-intron-Distal,intron-Proximal4.820454.40745K562SF3B4
    chr1715598711559902-intron-Distal,intron-Proximal4.808093.92230K562EFTUD2
    chr1715796841579745-intron-Distal,intron-Proximal3.490554.35431HepG2PRPF4
    chr1715817581581780-intron-Distal,intron-Proximal3.366173.54718K562PRPF8
    chr1715876661587709-intron-Distal,intron-Proximal4.127687.66928K562BUD13
    chr1715776741577736-intron-Distal,intron-Proximal4.0249025.69999K562AQR
    chr1715570191557068-intron-Distal,intron-Proximal4.940997.36776HepG2PRPF8
    chr1715867381586780-intron-Distal,intron-Proximal3.740344.79983HepG2U2AF2
    chr1715771891577266-intron-Distal,intron-Proximal5.573699.62108K562SF3B4
    chr1715772111577260-intron-Distal,intron-Proximal4.124753.02757HepG2AQR
    chr1715796821579745-intron-Distal,intron-Proximal4.308098.66247K562EFTUD2
    chr1715810141581040-intron-Distal,intron-Proximal3.7062711.77432K562KHSRP
    chr1715642121564286-intron-Distal,intron-Proximal3.260143.93669K562AQR
    chr1715628481562900-intron-Distal,intron-Proximal5.0420112.92555HepG2SF3A3
    chr1715617271561776-intron-Distal,intron-Proximal3.835624.33555K562EFTUD2
    chr1715641861564223-intron-Distal,intron-Proximal4.961814.83371K562EFTUD2
    ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




    The PRPF8 protein binds to its own RNA.

    RBP Chr Start End Strand log2(fold change) -log(p-value) Cell Line Matched Gene Matched Area
    PRPF8chr1715546701554710-4.972745.68502HepG2PRPF8CDS,intron-Distal,intron-Proximal
    PRPF8chr1715820441582069-4.799319.76577HepG2PRPF8CDS,intron-Distal,intron-Proximal
    PRPF8chr1715770091577041-4.048066.20582HepG2PRPF8CDS,intron-Distal,intron-Proximal
    PRPF8chr1715825441582587-4.3396112.61233HepG2PRPF8CDS,intron-Distal,intron-Proximal
    PRPF8chr1715777311577743-4.093459.48359K562PRPF8CDS,intron-Distal,intron-Proximal
    PRPF8chr1715794681579531-5.4039918.53372HepG2PRPF8CDS,intron-Distal,intron-Proximal
    PRPF8chr1715630871563169-3.9126625.62419HepG2PRPF8CDS,intron-Distal,intron-Proximal
    PRPF8chr1715771641577210-3.976195.34978HepG2PRPF8CDS,intron-Distal,intron-Proximal
    PRPF8chr1715839781584042-4.0866213.02279HepG2PRPF8CDS,intron-Distal,intron-Proximal
    PRPF8chr1715867941586848-5.657479.40852HepG2PRPF8CDS,intron-Distal,intron-Proximal
    PRPF8chr1715642381564296-3.3013011.38887K562PRPF8CDS,intron-Distal,intron-Proximal
    PRPF8chr1715808231580888-3.6047714.15837HepG2PRPF8CDS,intron-Distal,intron-Proximal
    PRPF8chr1715642491564311-4.0172221.74143HepG2PRPF8CDS,intron-Distal,intron-Proximal
    PRPF8chr1715784181578455-3.878235.64484HepG2PRPF8CDS,intron-Distal,intron-Proximal
    PRPF8chr1715776821577754-4.3108416.28235HepG2PRPF8CDS,intron-Distal,intron-Proximal
    PRPF8chr1715788611578897-5.056306.69228HepG2PRPF8intron-Distal,intron-Proximal
    PRPF8chr1715820111582044-4.892519.43475HepG2PRPF8intron-Distal,intron-Proximal
    PRPF8chr1715867311586798-4.2472811.71462K562PRPF8intron-Distal,intron-Proximal
    PRPF8chr1715766051576650-3.226225.84601HepG2PRPF8intron-Distal,intron-Proximal
    PRPF8chr1715776421577731-6.2182815.81095K562PRPF8intron-Distal,intron-Proximal
    PRPF8chr1715763371576373-4.556304.68690HepG2PRPF8intron-Distal,intron-Proximal
    PRPF8chr1715817581581780-3.366173.54718K562PRPF8intron-Distal,intron-Proximal
    PRPF8chr1715570191557068-4.940997.36776HepG2PRPF8intron-Distal,intron-Proximal


    Diffrential Expression
    • 10,494 differentially expressed genes after Knockdown/Knockout PRPF8 protein.  





    • 102 RBPs can affect the levels of PRPF8.  







    10,494 differentially expressed genes after Knockdown/Knockout PRPF8 protein :

    Only display 100 entries as example. Please click "View All" button to see all 10,494 entries.     

    Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
    DPM1ENSG00000000419.8579.003501166.01390-1.009907.771706.49940HepG2PRPF8
    SCYL3ENSG00000000457.9135.2366079.122800.773202.353701.60530HepG2PRPF8
    C1orf112ENSG00000000460.12107.13780294.90050-1.4608011.241909.76850HepG2PRPF8
    NFYAENSG00000001167.10660.13790889.39590-0.430102.815401.99950HepG2PRPF8
    LAS1LENSG00000001497.12413.47560591.65450-0.517002.949602.11720HepG2PRPF8
    SEMA3FENSG00000001617.7457.61630282.780300.694403.860702.92630HepG2PRPF8
    CD99ENSG00000002586.131583.661401212.948500.384602.310601.56930HepG2PRPF8
    MAD1L1ENSG00000002822.11154.68080240.50180-0.636802.769001.95970HepG2PRPF8
    KLHL13ENSG00000003096.941.467608.497902.286704.086803.12860HepG2PRPF8
    ALS2ENSG00000003393.101060.63150744.176500.511103.969003.02300HepG2PRPF8
    RBM5ENSG00000003756.122105.764401586.514600.408403.794502.86720HepG2PRPF8
    SLC7A2ENSG00000003989.121154.552102699.47960-1.2253024.0664022.06670HepG2PRPF8
    POLDIP2ENSG00000004142.71014.923901408.59680-0.472904.345403.35730HepG2PRPF8
    AK2ENSG00000004455.121204.996902100.76180-0.8019010.894509.43420HepG2PRPF8
    FKBP4ENSG00000004478.5669.294601315.17960-0.9745013.4946011.90500HepG2PRPF8
    KDM1AENSG00000004487.111767.571702183.37720-0.304802.012901.32050HepG2PRPF8
    CAMKK1ENSG00000004660.1013.3935038.83080-1.535702.167101.44970HepG2PRPF8
    CCDC132ENSG00000004766.11400.12330250.542400.675303.727502.80690HepG2PRPF8
    SLC25A13ENSG00000004864.9846.462901158.34370-0.452503.345602.46580HepG2PRPF8
    ST7ENSG00000004866.14157.71100268.94790-0.770003.833802.90260HepG2PRPF8
    DVL2ENSG00000004975.7250.64560536.70050-1.0985011.181109.71110HepG2PRPF8
    SKAP2ENSG00000005020.81327.25640508.317601.3845023.9243021.93200HepG2PRPF8
    SLC25A5ENSG00000005022.52157.345003406.07370-0.658908.928007.56650HepG2PRPF8
    DHX33ENSG00000005100.8709.498001116.62380-0.654306.063304.91900HepG2PRPF8
    LIG3ENSG00000005156.7266.98860586.85190-1.1362012.4933010.94710HepG2PRPF8
    ACSM3ENSG00000005187.7920.70720405.358501.1834015.4967013.80810HepG2PRPF8
    AC004381.6ENSG00000005189.1565.24230184.91950-1.503008.186606.88020HepG2PRPF8
    WDR54ENSG00000005448.1231.54220138.46030-2.1341011.073809.60710HepG2PRPF8
    CROTENSG00000005469.7565.97710191.859801.5606018.9240017.08710HepG2PRPF8
    RHBDD2ENSG00000005486.12600.19240317.330500.919307.230205.99630HepG2PRPF8
    ZNF195ENSG00000005801.12593.24140336.768300.816806.531405.35040HepG2PRPF8
    GGNBP2ENSG00000005955.81038.63120804.024300.369302.195101.47280HepG2PRPF8
    ASB4ENSG00000005981.847.09360103.68060-1.138503.268202.39760HepG2PRPF8
    GDE1ENSG00000006007.71616.326101152.668500.487604.148703.18250HepG2PRPF8
    OSBPL7ENSG00000006025.7309.76810153.702301.010905.878904.74940HepG2PRPF8
    TMEM98ENSG00000006042.7807.964701120.20450-0.471403.796202.86880HepG2PRPF8
    MAP3K14ENSG00000006062.9138.2718063.029601.133303.973203.02640HepG2PRPF8
    AP2B1ENSG00000006125.123567.003202650.189300.428504.048803.09400HepG2PRPF8
    CX3CL1ENSG00000006210.62961.393901276.965501.2135022.1317020.18130HepG2PRPF8
    TNFRSF12AENSG00000006327.9813.15290394.677901.0428012.0424010.52530HepG2PRPF8
    BAIAP2L1ENSG00000006453.9626.41800472.143300.407802.331301.58700HepG2PRPF8
    JHDM1DENSG00000006459.6722.36310964.93790-0.417702.424101.66640HepG2PRPF8
    AGKENSG00000006530.11317.55860448.15890-0.497002.542401.76740HepG2PRPF8
    PHTF2ENSG00000006576.12144.73070269.29200-0.895804.787903.75770HepG2PRPF8
    GGCTENSG00000006625.13301.61050501.18120-0.732605.212004.13840HepG2PRPF8
    DBF4ENSG00000006634.3214.74810383.76790-0.837605.413504.32340HepG2PRPF8
    PAF1ENSG00000006712.10483.92090642.33440-0.408602.487401.71950HepG2PRPF8
    VPS41ENSG00000006715.11795.88480555.957200.517503.846702.91380HepG2PRPF8
    ARHGAP44ENSG00000006740.1222.4711062.53750-1.476603.719502.79960HepG2PRPF8
    ARSDENSG00000006756.11258.37850144.990000.833404.187203.21770HepG2PRPF8
    ADIPOR2ENSG00000006831.91423.211401988.38380-0.482404.271903.29220HepG2PRPF8
    UPP2ENSG00000007001.827.659300.377406.195606.300205.13390HepG2PRPF8
    RHBDF1ENSG00000007384.11229.43690121.186800.920804.097903.13840HepG2PRPF8
    MYLIPENSG00000007944.10158.1456085.915100.880202.947002.11510HepG2PRPF8
    E2F2ENSG00000007968.643.65510207.67540-2.2501017.4337015.65990HepG2PRPF8
    CDK11AENSG00000008128.18503.81450376.009700.422002.031901.33520HepG2PRPF8
    CELSR3ENSG00000008300.10856.81130568.280200.592304.488103.48550HepG2PRPF8
    PLEKHG6ENSG00000008323.11282.16310149.355300.917704.535103.52840HepG2PRPF8
    SS18L2ENSG00000008324.687.27560176.07750-1.012604.347903.35940HepG2PRPF8
    MPNDENSG00000008382.1165.69000119.30000-0.860802.877102.05290HepG2PRPF8
    MGST1ENSG00000008394.8623.433801564.50510-1.3274024.4354022.41270HepG2PRPF8
    ST3GAL1ENSG00000008513.10458.41620711.22040-0.633605.221904.14770HepG2PRPF8
    IL32ENSG00000008517.122473.915901367.580100.8551012.0623010.54340HepG2PRPF8
    MAPK8IP2ENSG00000008735.10175.9125051.349901.776302.999102.16040HepG2PRPF8
    HEATR5BENSG00000008869.7827.37590531.613800.638105.119704.05620HepG2PRPF8
    RPS20ENSG00000008988.53057.574504114.61280-0.428404.184603.21560HepG2PRPF8
    REV3LENSG00000009413.111632.772901066.273000.614606.834105.62870HepG2PRPF8
    IYDENSG00000009765.1046.652402.001504.542708.943907.58120HepG2PRPF8
    BAZ1BENSG00000009954.61189.457002365.15660-0.9916015.6200013.92600HepG2PRPF8
    SPRTNENSG00000010072.11226.82310139.329700.703003.106002.25480HepG2PRPF8
    METTL13ENSG00000010165.15372.90520514.76260-0.465102.236401.50710HepG2PRPF8
    UQCRC1ENSG00000010256.61235.696302092.18910-0.7597010.474309.03410HepG2PRPF8
    STARD3NLENSG00000010270.9540.53330416.938400.374402.078701.37440HepG2PRPF8
    CD9ENSG00000010278.7214.33820130.750300.713002.851802.03040HepG2PRPF8
    NCAPD2ENSG00000010292.81194.646902813.76090-1.2359026.6086024.51120HepG2PRPF8
    IFFO1ENSG00000010295.15355.59260234.856500.598303.463602.57010HepG2PRPF8
    SEMA3GENSG00000010319.2142.58760311.40430-1.126907.698906.43110HepG2PRPF8
    IDSENSG00000010404.13603.97320450.142100.424002.687601.89060HepG2PRPF8
    SCMH1ENSG00000010803.12491.67360639.54500-0.379302.167401.44990HepG2PRPF8
    LYPLA2ENSG00000011009.6477.42260695.11560-0.542002.186901.46590HepG2PRPF8
    ABHD5ENSG00000011198.396.7615049.707500.960902.851402.03010HepG2PRPF8
    AKAP8LENSG00000011243.131136.35400648.287300.809608.975807.61170HepG2PRPF8
    UTP18ENSG00000011260.9535.38470778.26460-0.539703.675502.75950HepG2PRPF8
    PTBP1ENSG00000011304.122239.328903170.17650-0.501503.124702.27130HepG2PRPF8
    SYT7ENSG00000011347.556.60740101.13890-0.837302.323401.58000HepG2PRPF8
    PIK3C2AENSG00000011405.92273.904501822.533100.319102.809201.99430HepG2PRPF8
    ANLNENSG00000011426.6534.913901865.75080-1.8024043.7049041.16390HepG2PRPF8
    QPCTLENSG00000011478.785.11110298.92500-1.812405.334704.24910HepG2PRPF8
    BRCA1ENSG00000012048.15216.02370760.99110-1.8167030.0298027.82700HepG2PRPF8
    ERCC1ENSG00000012061.11209.55000300.82340-0.521602.222201.49560HepG2PRPF8
    EXTL3ENSG00000012232.4777.75420584.210400.412702.269601.53510HepG2PRPF8
    ELOVL5ENSG00000012660.92490.484601860.005700.421004.125903.16240HepG2PRPF8
    KDM5DENSG00000012817.111311.62440968.940900.436803.700002.78210HepG2PRPF8
    UBR7ENSG00000012963.9322.72700533.98930-0.726504.885003.84510HepG2PRPF8
    CLDN11ENSG00000013297.671.72590137.54260-0.939303.560702.65640HepG2PRPF8
    MVPENSG00000013364.141501.49170560.540301.4214024.4097022.39090HepG2PRPF8
    NUB1ENSG00000013374.11801.48610585.139700.453803.468702.57450HepG2PRPF8
    PGM3ENSG00000013375.111342.477001748.48550-0.381202.557401.78000HepG2PRPF8
    CLK1ENSG00000013441.111192.86260874.120600.448403.548002.64470HepG2PRPF8
    RNF14ENSG00000013561.13336.97640225.063600.582202.962702.12900HepG2PRPF8
    Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

    *: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
    **: "-log(0)" was displayed as "99999.99999".





    102 RBPs can affect the gene expression of PRPF8 :

    Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
    PRPF8ENSG00000174231.127273.896009650.89910-0.4079012.7869011.68230HepG2ACO1
    PRPF8ENSG00000174231.128508.938109695.77120-0.188402.687301.93050HepG2AKAP8L
    PRPF8ENSG00000174231.1211325.6623013534.77070-0.257104.898904.02760HepG2AUH
    PRPF8ENSG00000174231.125677.326808252.88870-0.539705.820704.43920HepG2BCCIP
    PRPF8ENSG00000174231.124278.036807170.67290-0.7452010.912009.27840HepG2BCLAF1
    PRPF8ENSG00000174231.127177.701109817.36820-0.451808.290507.05830HepG2CALR
    PRPF8ENSG00000174231.1212924.099009648.235900.4216016.7821015.44160HepG2CKAP4
    PRPF8ENSG00000174231.125033.689206808.92700-0.435802.390601.68250HepG2CNOT7
    PRPF8ENSG00000174231.126598.186908727.51470-0.403503.433702.67560HepG2CPSF6
    PRPF8ENSG00000174231.126708.5153010934.57670-0.7048025.1645023.62670HepG2CELF1
    PRPF8ENSG00000174231.1210062.3924011756.09100-0.224403.623202.79500HepG2DAZAP1
    PRPF8ENSG00000174231.1210552.463408925.438900.241505.134704.04550HepG2DDX19B
    PRPF8ENSG00000174231.126734.663608841.88390-0.392704.888504.01410HepG2DDX21
    PRPF8ENSG00000174231.127141.284508651.65060-0.276803.229002.24080HepG2DDX24
    PRPF8ENSG00000174231.127417.3681010142.61740-0.451504.552403.76490HepG2DDX3X
    PRPF8ENSG00000174231.125985.233208114.53400-0.439104.174403.24600HepG2DDX55
    PRPF8ENSG00000174231.127276.351709910.83570-0.445802.176701.31390HepG2DDX59
    PRPF8ENSG00000174231.126659.999308336.29050-0.323905.590804.62070HepG2DNAJC21
    PRPF8ENSG00000174231.126157.021608263.15180-0.4245015.5773014.15600HepG2DNAJC2
    PRPF8ENSG00000174231.126074.987908141.39370-0.422403.122501.93820HepG2AGO1
    PRPF8ENSG00000174231.127112.591509255.81170-0.380002.932602.27410HepG2EIF4A3
    PRPF8ENSG00000174231.128273.8354011111.09010-0.425404.799403.74380HepG2EIF4G2
    PRPF8ENSG00000174231.1213448.7300015540.22840-0.208503.829903.14300HepG2ETF1
    PRPF8ENSG00000174231.126667.723108425.57400-0.337604.030302.68890HepG2FASTKD2
    PRPF8ENSG00000174231.128706.155206622.436400.394603.957803.02600HepG2FUBP3
    PRPF8ENSG00000174231.1211305.585009339.781200.275502.039001.44180HepG2FXR1
    PRPF8ENSG00000174231.127198.021108416.15970-0.225602.022101.45960HepG2HNRNPA1
    PRPF8ENSG00000174231.129267.4933010804.79400-0.221403.212002.21540HepG2HNRNPA2B1
    PRPF8ENSG00000174231.1215033.254408773.835600.7768015.5873014.06720HepG2HNRNPK
    PRPF8ENSG00000174231.128433.3788010708.51590-0.3446011.3126010.03220HepG2HNRNPL
    PRPF8ENSG00000174231.127444.505809440.64720-0.342702.640702.02320HepG2HNRNPLL
    PRPF8ENSG00000174231.128044.538909299.67410-0.209203.452302.78270HepG2HNRNPU
    PRPF8ENSG00000174231.127015.854209499.28230-0.4372018.0631016.37550HepG2ILF2
    PRPF8ENSG00000174231.126672.633707985.55730-0.259102.463101.39720HepG2LARP7
    PRPF8ENSG00000174231.125553.496809343.04660-0.7505011.3268010.03220HepG2MAGOH
    PRPF8ENSG00000174231.127749.385909395.16690-0.277801.834201.31510HepG2MATR3
    PRPF8ENSG00000174231.128554.3654010092.78460-0.238602.462001.69720HepG2MSI2
    PRPF8ENSG00000174231.125712.463107220.44820-0.338003.462501.87990HepG2NIP7
    PRPF8ENSG00000174231.128503.1559011657.38330-0.455208.825607.48820HepG2NOL12
    PRPF8ENSG00000174231.127068.746409204.88840-0.380909.197507.79720HepG2PARN
    PRPF8ENSG00000174231.127605.054309215.93940-0.277203.459502.79740HepG2PCBP1
    PRPF8ENSG00000174231.127139.802708294.53870-0.216302.427601.73320HepG2PPIL4
    PRPF8ENSG00000174231.1213377.8464011616.443200.203603.048802.24180HepG2PRPF4
    PRPF8ENSG00000174231.121861.265006258.48090-1.7495057.0174054.09740HepG2PRPF8
    PRPF8ENSG00000174231.127118.833309377.70200-0.3976010.422409.49170HepG2PTBP1
    PRPF8ENSG00000174231.127979.4362011804.75290-0.5650012.5089011.14330HepG2PUM2
    PRPF8ENSG00000174231.127521.376809829.98390-0.3862011.6987010.58230HepG2PUS1
    PRPF8ENSG00000174231.125963.861409016.07680-0.596303.641602.83550HepG2RAVER1
    PRPF8ENSG00000174231.1211483.8871014109.78930-0.297103.937302.93540HepG2RBM15
    PRPF8ENSG00000174231.127210.1712012988.65090-0.8491035.7803034.32790HepG2RBM22
    PRPF8ENSG00000174231.128817.0009011926.50070-0.435806.339805.36470HepG2RPLP0
    PRPF8ENSG00000174231.126311.031108880.68880-0.492806.466205.27280HepG2RPS2
    PRPF8ENSG00000174231.126263.503209065.40540-0.533407.355805.62330HepG2RPS5
    PRPF8ENSG00000174231.126779.816008281.67840-0.288706.993606.03720HepG2SAFB2
    PRPF8ENSG00000174231.127757.302009657.68020-0.3161010.645509.51610HepG2SMN1
    PRPF8ENSG00000174231.1212351.5709014670.01880-0.248206.033105.37220HepG2SRFBP1
    PRPF8ENSG00000174231.1211549.7944010190.715400.180503.133602.63880HepG2SRSF1
    PRPF8ENSG00000174231.129040.7538010988.10830-0.281405.009504.20650HepG2SRSF5
    PRPF8ENSG00000174231.128073.6833010876.29410-0.429907.521006.46460HepG2SRSF7
    PRPF8ENSG00000174231.125887.651508290.77750-0.4938016.5358015.38990HepG2SRSF9
    PRPF8ENSG00000174231.1210457.4181012736.72740-0.284506.547805.82210HepG2SSB
    PRPF8ENSG00000174231.126144.643508426.19980-0.455602.956101.71220HepG2SUB1
    PRPF8ENSG00000174231.125807.582608077.53790-0.476005.090204.21750HepG2SUPV3L1
    PRPF8ENSG00000174231.123962.333205413.87370-0.450304.693703.44300HepG2TFIP11
    PRPF8ENSG00000174231.126446.741009035.78110-0.487109.428508.60250HepG2TIAL1
    PRPF8ENSG00000174231.127205.993709117.18770-0.339407.711506.84720HepG2TRIM56
    PRPF8ENSG00000174231.122577.924004771.40720-0.8882015.7990014.02490HepG2UCHL5
    PRPF8ENSG00000174231.1210319.0095012112.65300-0.231204.606203.74300HepG2UPF1
    PRPF8ENSG00000174231.125014.990307395.61400-0.560404.832403.48660HepG2UPF2
    PRPF8ENSG00000174231.1210922.7585012450.09140-0.188802.565501.55070HepG2UTP18
    PRPF8ENSG00000174231.1210572.8449011694.28610-0.145402.061901.52930HepG2UTP3
    PRPF8ENSG00000174231.126604.308908868.90470-0.425302.756001.49370HepG2XRCC5
    PRPF8ENSG00000174231.125723.777407951.46090-0.474305.759604.72550HepG2XRN2
    PRPF8ENSG00000174231.1210497.4387011464.17170-0.127102.022201.43440HepG2ZC3H8
    PRPF8ENSG00000174231.1211401.3126013321.59550-0.224605.835705.11850HepG2ZNF622
    PRPF8ENSG00000174231.126516.524109010.83660-0.467603.382401.93950HepG2ZRANB2
    PRPF8ENSG00000174231.1219111.8055013627.611400.4878017.7952016.47640K562AGGF1
    PRPF8ENSG00000174231.1217545.5725014180.224200.307103.355202.63500K562AKAP8L
    PRPF8ENSG00000174231.1216731.1322013516.946700.307703.044302.43500K562AQR
    PRPF8ENSG00000174231.128207.712409582.68230-0.223404.054102.87610K562BCLAF1
    PRPF8ENSG00000174231.1213445.0423016285.49340-0.276503.232301.94390K562CCDC124
    PRPF8ENSG00000174231.127886.520909113.74890-0.208701.984801.31170K562CPSF6
    PRPF8ENSG00000174231.1215087.5641010226.377600.561007.971006.35170K562EFTUD2
    PRPF8ENSG00000174231.1210233.9304012793.03680-0.322006.161105.15120K562EIF2S2
    PRPF8ENSG00000174231.127761.712706353.327300.288804.304503.32270K562EIF3G
    PRPF8ENSG00000174231.125610.689009795.98910-0.8040017.1098014.92150K562EIF4A3
    PRPF8ENSG00000174231.129713.2866012461.07500-0.359403.992302.96090K562FIP1L1
    PRPF8ENSG00000174231.126384.145807860.74410-0.300202.304001.47390K562FTO
    PRPF8ENSG00000174231.125205.430207506.97110-0.528203.287902.50420K562G3BP2
    PRPF8ENSG00000174231.129675.8474017046.90490-0.8170022.3270020.07020K562GRSF1
    PRPF8ENSG00000174231.128146.2653010022.15970-0.299003.472902.81430K562HNRNPC
    PRPF8ENSG00000174231.127828.1186010249.71810-0.388803.383202.34650K562HNRNPM
    PRPF8ENSG00000174231.1210088.6198016894.14300-0.7438014.3848012.63810K562HSPD1
    PRPF8ENSG00000174231.1218110.7721015048.492600.267102.763201.93800K562KIF1C
    PRPF8ENSG00000174231.126176.719309931.10500-0.6851011.604509.79990K562MAGOH
    PRPF8ENSG00000174231.1212539.1095014344.53300-0.194103.410402.51730K562MTPAP
    PRPF8ENSG00000174231.1216805.5734011816.366200.508103.910602.81110K562NAA15
    PRPF8ENSG00000174231.1214419.835507794.612900.887403.680602.49420K562PABPN1
    PRPF8ENSG00000174231.1212135.021308835.454700.457706.675705.13570K562PCBP2
    PRPF8ENSG00000174231.1212429.8824016513.26860-0.409804.001803.00170K562PCBP3
    PRPF8ENSG00000174231.129882.7084012666.15870-0.358005.381404.26530K562POLR2G
    PRPF8ENSG00000174231.1210015.6584014146.22630-0.498206.531505.17550K562PPIG
    PRPF8ENSG00000174231.125437.650309951.47420-0.8719018.4461016.49470K562PRPF8
    PRPF8ENSG00000174231.1217326.8070022304.23320-0.364307.690806.06440K562PUM2
    PRPF8ENSG00000174231.1223939.1014014062.343000.7674011.9207010.84190K562PUS1
    PRPF8ENSG00000174231.1220096.9361013702.089300.5525015.1366013.73390K562RBM15
    PRPF8ENSG00000174231.129824.9884011821.39060-0.266902.179601.30140K562RPS3
    PRPF8ENSG00000174231.1215732.967607126.684301.142406.799704.63540K562SF1
    PRPF8ENSG00000174231.1210136.259807800.208700.377802.934902.05310K562SF3B4
    PRPF8ENSG00000174231.1220463.605008187.186401.321509.633206.89160K562SNRNP200
    PRPF8ENSG00000174231.1214439.3756016112.29380-0.158203.037402.06250K562SRPK2
    PRPF8ENSG00000174231.126067.142309633.57410-0.667108.949607.06960K562SUPV3L1
    PRPF8ENSG00000174231.127665.8245010196.75430-0.411604.469403.14610K562UCHL5
    PRPF8ENSG00000174231.1213775.7830016899.70170-0.294907.262606.16480K562UPF1
    Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

    *: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
    **: "-log(0)" was displayed as "99999.99999".





    3,616 alternative splicing events after Knockdown/Knockout PRPF8 protein :

    Only display 100 entries as example. Please click "View All" button to see all 3,616 entries.     

    Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
    SERP11-552F3.12ENSG00000267426.1chr17-7390030273900394738981007389823573900620739008000.095000.000550.02350includedK562PRPF8
    SEZBTB8OSENSG00000176261.11chr1-3310036833100393330995513309971133116033331161610.068000.002150.06559includedK562PRPF8
    SEIMMP1LENSG00000148950.5chr11-3150967431509788314990473149930631531065315311420.656000.000010.00111includedK562PRPF8
    SEILF3ENSG00000129351.13chr19+1079509110795152107945921079464610798021107983840.145000.000960.03606includedK562PRPF8
    SEYWHAZENSG00000164924.13chr8-1019641561019643561019608411019611281019654961019656160.151000.000010.00092includedK562PRPF8
    SEDEAF1ENSG00000177030.12chr11-6896046898136883306884606915006915970.103000.000340.01616includedK562PRPF8
    SEKDM5BENSG00000117139.12chr1-2027355242027356322027331762027332732027360532027361880.104000.002020.06265includedK562PRPF8
    SEUBE2D2ENSG00000131508.11chr5+1389418281389419921389407501389414001389799561389800200.107000.000020.00159includedK562PRPF8
    SEDLG1ENSG00000075711.16chr3-1968576721968578491968573971968575421968634121968635490.103000.001210.04346includedK562PRPF8
    SESIN3BENSG00000127511.5chr19+1697397916974173169731621697337016974490169746070.283000.000150.00829includedK562PRPF8
    SENUPL1ENSG00000139496.11chr13+2587723925877293258757622587601825881943258820870.176000.000050.00317includedK562PRPF8
    SEDROSHAENSG00000113360.12chr5-3140980731409849314093563140943931410852314109940.113000.000470.02059includedK562PRPF8
    SEHIAT1ENSG00000156875.9chr1+1005086281005087851005036521005038721005154641005155600.058000.001800.05758includedK562PRPF8
    SEVWDEENSG00000146530.7chr7-1238455812384737123839991238409512385364123855860.111000.003420.09250includedK562PRPF8
    SECNOT6ENSG00000113300.7chr5+1799224201799225881799215741799217631799562741799563880.238000.000220.01120includedK562PRPF8
    SERANENSG00000132341.7chr12+1313571281313571621313566201313566711313573801313574650.123000.003790.09959includedK562PRPF8
    SEIVNS1ABPENSG00000116679.11chr1-1852756161852757571852746671852747751852761451852762710.248000.000000.00000includedK562PRPF8
    SESLC25A23ENSG00000125648.10chr19-6455962645610364545696454728645643064565420.067000.003640.09684includedK562PRPF8
    SERBX1ENSG00000100387.8chr22+4136005041360238413473624134748041368479413693130.205000.002750.07844includedK562PRPF8
    SECEP57ENSG00000166037.6chr11+9552867995528723955236769552390795532395955325520.178000.000220.01134includedK562PRPF8
    SEDSCR3ENSG00000157538.9chr21-3859842238598486385975553859792738599954386001070.071000.002910.08175includedK562PRPF8
    SETMEM194AENSG00000166881.5chr12-5746301657463089574584285745852257464602574646760.220000.002400.07083includedK562PRPF8
    SEHMMRENSG00000072571.15chr5+1628947061628947541628917281628918081628966461628968350.215000.000290.01413includedK562PRPF8
    SESTK11ENSG00000118046.10chr19+1221694122184512212111221339122194712220050.051000.000590.02482includedK562PRPF8
    SEHCFC1ENSG00000172534.9chrX-1532264881532266241532256851532258651532269921532270990.061000.000000.00031includedK562PRPF8
    SEZC3H11AENSG00000058673.11chr1+2037654202037656242037648332037649222037707022037707560.186000.000100.00596includedK562PRPF8
    SESERPINB1ENSG00000021355.8chr6-2839568283970028387822838920284065228408280.052000.003530.09464includedK562PRPF8
    SEUBE2J2ENSG00000160087.16chr1-1201477120167011987251198766120324112033720.071000.000710.02890includedK562PRPF8
    SEUBE2J2ENSG00000160087.16chr1-1191424119150511902841190867119237111925100.055000.000010.00099includedK562PRPF8
    SEZBTB40ENSG00000184677.12chr1+2282836922828464228279842282817722828791228289340.149000.001140.04143includedK562PRPF8
    SEMVDENSG00000167508.6chr16-8872843188728575887250578872512888729418887295690.073000.000000.00000includedK562PRPF8
    SEEIF4HENSG00000106682.10chr7+7360457673604636736041517360424873609070736092080.131000.000000.00005includedK562PRPF8
    SESF3B3ENSG00000189091.8chr16+7058455270584581705822727058234570588348705885000.052000.000830.03253includedK562PRPF8
    SESREK1ENSG00000153914.11chr5+6545189265454760654492906544942465455046654551620.300000.000000.00000includedK562PRPF8
    SEWNK1ENSG00000060237.12chr12+9887389891979873779875279898869901650.263000.003770.09911includedK562PRPF8
    SEGPBP1L1ENSG00000159592.6chr1-4615124746151292461262204612689746153654461537850.208000.000070.00461includedK562PRPF8
    SEMOCS2ENSG00000164172.14chr5-5240508052405238524043515240447352405541524055570.129000.000060.00370includedK562PRPF8
    SETANKENSG00000136560.9chr2+1620177951620179231620168591620169971620361241620362720.197000.000700.02865includedK562PRPF8
    SEDCAF16ENSG00000163257.6chr4-1781115917811315178067291780684817812069178123340.212000.001290.04519includedK562PRPF8
    SEIST1ENSG00000182149.16chr16+7195625471956277719552457195535671956376719565830.138000.000000.00000includedK562PRPF8
    SEDECR1ENSG00000104325.2chr8+9102935191029554910136329101378991031136910311940.095000.001960.06152includedK562PRPF8
    SEFUBP3ENSG00000107164.15chr9+1335065471335066801335060141335061751335069431335070170.081000.000390.01796includedK562PRPF8
    SEPPARDENSG00000112033.9chr6+3531613935316215353148433531492735378763353789940.228000.001580.05242includedK562PRPF8
    SESMC6ENSG00000163029.11chr2-1793424417934331179270931792721817934892179350400.297000.000080.00474includedK562PRPF8
    SETOP3BENSG00000100038.15chr22-2233035222330559223300112233017922337126223371840.088000.000730.02963includedK562PRPF8
    SEATP5F1ENSG00000116459.6chr1+1119987071119987381119924581119924951119988481119988710.342000.002070.06403includedK562PRPF8
    SEHBE1ENSG00000213931.1chr11-5303138530318152910285291386536700253671290.208000.000040.00286includedK562PRPF8
    SEGOLPH3LENSG00000143457.6chr1-1506665831506666491506361071506362391506671311506673260.114000.001690.05494includedK562PRPF8
    SEVPS13BENSG00000132549.14chr8+1001464621001465741001334041001336731001468591001469550.211000.002780.07879includedK562PRPF8
    SESEC24CENSG00000176986.10chr10+7550638775506474755041487550419575506562755067620.097000.000000.00000includedK562PRPF8
    SEHNRNPA2B1ENSG00000122566.16chr7-2623745026237486262372412623735226240191262403660.058000.002280.06838includedK562PRPF8
    SEMFHAS1ENSG00000147324.6chr8-8647833864794486435348643565865487486550010.168000.000200.01059includedK562PRPF8
    SETCF3ENSG00000071564.10chr19-1612205161243216117021611848161528316154840.177000.002460.07216includedK562PRPF8
    SESEP15ENSG00000183291.11chr1-8735283887352879873463448734640887368963873690350.052000.000080.00496includedK562PRPF8
    SEAC013394.2ENSG00000272888.1chr15+9342681493427008934262449342641693428744934288140.412000.000000.00000includedK562PRPF8
    SEPQLC3ENSG00000162976.8chr2+1131509311315135113120501131217111317862113190000.440000.002120.06492includedK562PRPF8
    SECDC5LENSG00000096401.7chr6+4439502944395110443942184439446144397449443975330.062000.000010.00111includedK562PRPF8
    SESTX16ENSG00000124222.17chr20+5723467857234690572269215722714357242545572426530.203000.003640.09694includedK562PRPF8
    SESUN1ENSG00000164828.13chr7+8891568892408881408882528895598896700.163000.000860.03334includedK562PRPF8
    SESUN1ENSG00000164828.13chr7+8826038826768815828817678828428828690.119000.000060.00383includedK562PRPF8
    SENBR1ENSG00000188554.9chr17+4132309041323319413225104132296041327807413279180.439000.000000.00007includedK562PRPF8
    SEPOFUT2ENSG00000186866.12chr21-4669744546697688466969314669705746698017466980840.067000.001370.04734includedK562PRPF8
    SEARPP19ENSG00000128989.6chr15-5285638652856443528492965284941952861044528610990.077000.001120.04083includedK562PRPF8
    SECALM2ENSG00000143933.12chr2-4739955247399598473978724739790347403579474036500.447000.001780.05723includedK562PRPF8
    SECPED1ENSG00000106034.13chr7+1208848951208850631208842551208843921209062801209065010.079000.000000.00002includedK562PRPF8
    SEKLHL12ENSG00000117153.11chr1-2028848582028849002028801812028803312028872982028875160.133000.000000.00024includedK562PRPF8
    SESLC11A2ENSG00000110911.10chr12-5139943551399460513990935139921951402258514024070.243000.000040.00267includedK562PRPF8
    SEHMBOX1ENSG00000147421.13chr8+2890370828903933289028772890296028904874289049700.234000.003100.08602includedK562PRPF8
    SEHMBOX1ENSG00000147421.13chr8+2886889028869036288665882886669928876276288764300.096000.001770.05698includedK562PRPF8
    SEUSP24ENSG00000162402.8chr1-5557107255571194555695485556969355571818555719360.111000.000220.01130includedK562PRPF8
    SEWTAPENSG00000146457.10chr6+1601623931601624791601600211601600771601631191601631780.056000.000310.01504includedK562PRPF8
    SEANXA2ENSG00000182718.12chr15-6068834960688626606782266067828560689456606895370.193000.000000.00008includedK562PRPF8
    SELATS1ENSG00000131023.8chr6-1500182271500183221500162091500163571500229141500234020.181000.000030.00246includedK562PRPF8
    SECDCA7ENSG00000144354.9chr2+1742287271742288891742285451742286231742295221742296010.108000.000600.02510includedK562PRPF8
    SEXPCENSG00000154767.10chr3-1419537814195533141938341419391614197834141979950.099000.000680.02803includedK562PRPF8
    SEMAGEC2ENSG00000046774.9chrX-1412919161412919931412901301412918391412921471412922410.065000.001690.05494includedK562PRPF8
    SECCDC84ENSG00000186166.4chr11+1188723221188725351188697201188698191188814731188815400.498000.003560.09527includedK562PRPF8
    SEFHL2ENSG00000115641.14chr2-1060131031060131541060028171060029971060152981060156810.377000.000930.03531includedK562PRPF8
    SECD33ENSG00000105383.10chr19+5174232751742559517387855173893151742772517432700.108000.000020.00163includedK562PRPF8
    SEWIPI2ENSG00000157954.10chr7+5232748523280252298185230124523920652392890.232000.000790.03136includedK562PRPF8
    SEZNF138ENSG00000197008.5chr7+6427529564275422642548026425494964291828642940420.296000.003480.09352includedK562PRPF8
    SENDUFS4ENSG00000164258.7chr5+5290055352900725528992815289936052942062529422350.055000.000350.01658includedK562PRPF8
    SEUSO1ENSG00000138768.10chr4+7671648876716509767148427671505476720774767208850.098000.000030.00221includedK562PRPF8
    SEGPS1ENSG00000169727.8chr17+8001013480010335800097728000984080011149800112420.053000.002020.06265includedK562PRPF8
    SESSBP3ENSG00000157216.11chr1-5472374154723822547227995472285954747110547472000.203000.000230.01144includedK562PRPF8
    SECUL2ENSG00000108094.10chr10-3537882335378929353601263536026735379106353792920.288000.001550.05175includedK562PRPF8
    SERABGAP1LENSG00000152061.17chr1+1749270271749273101749265931749266861749384131749385240.397000.000750.02996includedK562PRPF8
    SEGALNT12ENSG00000119514.5chr9+1015956131015957951015940531015942391015975301015976480.109000.001290.04536includedK562PRPF8
    SEHNRNPCENSG00000092199.13chr14-2173182521731988217314692173149521737456217375650.055000.000010.00124includedK562PRPF8
    SEDMTF1ENSG00000135164.14chr7+8678370586783844867817518678187186792810867929330.213000.000620.02588includedK562PRPF8
    SEFRG1ENSG00000109536.7chr4+1908761911908763061908733161908734421908785521908786570.132000.000820.03228includedK562PRPF8
    SEEXOC7ENSG00000182473.16chr17-7408640974086478740852557408540174090494740906620.258000.003450.09312includedK562PRPF8
    SEPCID2ENSG00000126226.17chr13-1138623371138625201138546941138548301138629121138629430.122000.000000.00000includedK562PRPF8
    SESPTA1ENSG00000163554.7chr1-1586246541586247411586244351586245381586263531586264460.146000.001670.05461includedK562PRPF8
    SEUPF3AENSG00000169062.10chr13+1150483111150484181150473991150476021150519931150521040.149000.002410.07117includedK562PRPF8
    SEUBAP2ENSG00000137073.16chr9-3401162434011662339964753399886234017047340171870.121000.002550.07432includedK562PRPF8
    SEUSP14ENSG00000101557.10chr18+1629821631741585561587141633071634310.112000.000000.00024includedK562PRPF8
    SEOTUD5ENSG00000068308.9chrX-4879346148793629487922264879229148801450488015440.052000.000000.00014includedK562PRPF8
    SESNX19ENSG00000120451.6chr11-1307500631307502201307495181307496061307505161307510360.088000.002430.07150includedK562PRPF8
    SESLC25A51ENSG00000122696.8chr9-3790352737903554378998253789994737904064379043500.271000.000540.02320includedK562PRPF8





    6 RBPs can affect the splicing of PRPF8 :

    Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
    SEPRPF8ENSG00000174231.12chr17-157703915771861576650157686115777351577974-0.137000.000000.00049excludedHepG2PRPF8
    SEPRPF8ENSG00000174231.12chr17-156428615644561563991156412115645641564700-0.063000.000000.00000excludedK562AQR
    SEPRPF8ENSG00000174231.12chr17-157703915772241576650157686115777351577974-0.059000.000260.00390excludedK562AQR
    SEPRPF8ENSG00000174231.12chr17-157703915771751576650157686115777351577974-0.088000.002480.06176excludedHepG2SF3A3
    SEPRPF8ENSG00000174231.12chr17-156490415650401564564156470015651991565332-0.081000.000130.00337excludedK562HNRNPC
    A3SSPRPF8ENSG00000174231.12chr17-1562650156286715626501562842156313415632950.052000.000000.00003longerHepG2SF3A3
    A3SSPRPF8ENSG00000174231.12chr17-1562650156286715626501562842156313415632950.051000.000000.00010longerK562AKAP8L
    A3SSPRPF8ENSG00000174231.12chr17-1585422158561115854221585587158682615870710.072000.000000.00000longerK562AQR
    A3SSPRPF8ENSG00000174231.12chr17-1579221157942315792211579348157950015796640.063000.000000.00000longerK562AQR
    A3SSPRPF8ENSG00000174231.12chr17-1584222158440515842221584348158477115849840.085000.000000.00000longerK562AQR
    A3SSPRPF8ENSG00000174231.12chr17-1577937157798815779371577974157844515786730.101000.000000.00000longerK562AQR
    A3SSPRPF8ENSG00000174231.12chr17-1576650157689415766501576861157703915772240.064000.000000.00000longerK562AQR
    A3SSPRPF8ENSG00000174231.12chr17-1562650156286715626501562842156313415632950.263000.000000.00000longerK562AQR
    A3SSPRPF8ENSG00000174231.12chr17-1554941155515715549411555082155683515569770.094000.000000.00000longerK562AQR
    A3SSPRPF8ENSG00000174231.12chr17-1586826158705815868261586995158776515881310.051000.000000.00000longerK562AQR
    A3SSPRPF8ENSG00000174231.12chr17-1587765158796215877651587876158807315881460.096000.000000.00000longerK562AQR
    A3SSPRPF8ENSG00000174231.12chr17-1579500157970715795001579664157979815800050.074000.000000.00000longerK562AQR
    A3SSPRPF8ENSG00000174231.12chr17-1577039157722415770391577186157773515779740.111000.000000.00000longerK562AQR
    A3SSPRPF8ENSG00000174231.12chr17-1582055158222515820551582175158231015825000.094000.000000.00000longerK562AQR
    A3SSPRPF8ENSG00000174231.12chr17-1562650156286715626501562842156313415632950.082000.000000.00000longerK562PUS1
    RIPRPF8ENSG00000174231.12chr17-156181915620571561819156189715619761562057-0.057000.000000.00012excludedHepG2SF3A3
    RIPRPF8ENSG00000174231.12chr17-156275715632951562757156286715631341563295-0.480000.000000.00000excludedK562AQR

    *: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
    **: "-log(0)" was displayed as "99999.99999".





    The PRPF8 protein affects to its own RNA splicing after knockdown/knockout.

    Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
    SEPRPF8ENSG00000174231.12chr17-157703915771861576650157686115777351577974-0.137000.000000.00049excludedHepG2PRPF8