DDX59

General Information

Gene Name       : DDX59
Gene ID             : ENSG00000118197.13
Essential Gene : Yes

Functions

Localization(RBPImage: DDX59)

Domains (AlphaFold: DDX59)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878DDX59ENSG00000118197.1322.5528.6325.59ENCSR000AEF
HepG2DDX59ENSG00000118197.138.5614.4611.51ENCSR985KAT
K562DDX59ENSG00000118197.1315.2520.4217.84ENCSR000AEO

Assays

4 Released experiments are available on ENCORE database.

Assay TypeExp_NameENCODE IDTarget labelBiosampleStatusLinked AntibodyControlsMethodNote
eCLIPeCLIP: 603ENCSR214BZADDX59HepG2ReleasedENCAB112HZSENCSR334OMC  
knockdown followed by RNA-seq DDX59-BGHLV18-HepG2ENCSR067AUGDDX59HepG2ReleasedENCSR674KEK   shRNAKD% = 27.1,39.3
knockdown followed by RNA-seq DDX59-BGHLV35-HepG2ENCSR598GKQDDX59HepG2ReleasedENCSR264TUE   shRNAKD% = 73.3,65.6
knockdown followed by RNA-seq DDX59-BGKcLV08-K562ENCSR126UCLDDX59K562ReleasedENCSR015KGT   CRISPRKD% = 76.0,76.0






  eCLIP  
  RBP    Exp_UID    Cell_Line    ENCODE_ACCESSION    Control_ENCODE_ACCESSION    ENCODE_Antibody_ID    Antibody    Lot_num    Status    Project  
DDX59603HepG2ENCSR214BZAENCSR334OMCENCAB112HZSA303-028A1ReleasedENCODE3


  Antibody Validation  
  GeneName    Antibody_DCC_ID    Product_ID    Lot_ID    Phosphate    HepG2 Primary Validation    K562 Primary Validation    HepG2 Secondary Validation    K562 Secondary Validation  
DDX59ENCAB112HZSA303-028A1Released, ENCODE3BGHLV35-15, Released, ENCODE3BGKcLV08-23, Released, ENCODE4


  KD RNA-Seq  
  GeneName    Cell_Line    Method    Exp_ID    Control_ID    Sample_reps    Control_reps    KD%    Status    Project    Note  
DDX59K562shRNABGKLV21-9,BGKLV21-10BGKLV21-1,BGKLV21-2redo transduction,redo transductionNotSatisfiedENCODE3
DDX59K562shRNABGKLV36-13,BGKLV36-14BGKLV36-1,BGKLV36-238.9,37.6NotSatisfiedENCODE4bad KD%
DDX59HepG2shRNAENCSR067AUGENCSR674KEKDDX59_BGHLV18_3,DDX59_BGHLV18_4NT_BGHLV18_1,NT_BGHLV18_227.1,39.3ReleasedENCODE3
DDX59HepG2shRNAENCSR598GKQENCSR264TUEDDX59_BGHLV35-15,DDX59_BGHLV35-16NT_BGHLV35-1,NT_BGHLV35-273.3,65.6ReleasedENCODE3
DDX59K562CRISPRENCSR126UCLENCSR015KGTDDX59-BGKcLV08-23,DDX59-BGKcLV08-24NT-BGKcLV08-1,NT-BGKcLV08-276.0,76.0ReleasedENCODE4
DDX59K562CRISPRBGKcLV08-25,BGKcLV08-26BGKcLV08-1,BGKcLV08-20.0,8.0NotSatisfiedENCODE4
DDX59Ribo-STAMP-293TshRNABGRSLV01-5,BGRSLV01-6BGRSLV01-1,BGRSLV01-2NotSatisfiedENCORE2
DDX59Ribo-STAMP-293TshRNADDX59-BGRSLV02-23,DDX59-BGRSLV02-24NT-BGRSLV02-1,NT-BGRSLV02-2,SubmittedENCORE2
DDX59Ribo-STAMP-293TshRNABGRSDLV04-9,BGRSDLV04-10BGRSDLV04-1,BGRSDLV04-2SubmittedENCORE2
DDX59Ribo-STAMP-293TshRNADDX59-BGRSDLV04-11dox,DDX59-BGRSDLV04-12doxNT-BGRSDLV04-3dox,NT-BGRSDLV04-4dox,SubmittedENCORE2


  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  
    DDX59: Click to RBP Image Database
  • Cytoplasm
  • Compartment/Organelle
  • Mitochondria












    • RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela
    DDX59Product_ID: A303-028A
    Lot_ID: 1
    Source: Bethyl Labs
    Target Name: DDX59-human    		 HepG2_Bethyl_A303-028A_1_DDX59.png<br>Caption: IP-Western Blot analysis of HepG2 whole cell lysate using DDX59 specific antibody. Lane 1 is 1% of twenty million whole cell lysate input and lane 2 is 25% of IP enrichment using rabbit normal IgG (lanes under 'IgG'). Lane 3 is 1% of twenty million whole cell lysate input and lane 4 is 10% IP enrichment using rabbit polyclonal anti-DDX59 antibody (lanes under 'DDX59').
    		 DDX59-HEPG2.png<br>Caption: Western blot following shRNA against DDX59 in HepG2 whole cell lysate using DDX59 specific antibody. Lane 1 is a ladder, lane 2 is HepG2 non-targeting control knockdown, lane 3 and 4 are two different shRNAs against DDX59.DDX59 protein appears as the green arrow, GAPDH serves as a control and appears in red arrow.
    		 DDX59-K562-CRISPR.png<br>Caption: Western blot following CRISPR against DDX59 in K562 whole cell lysate using DDX59 specific antibody. Lane 1 is a ladder, lane 2 is K562 non-targeting control knockdown, lane 3 and 4 are two different CRISPR against DDX59.DDX59 protein appears as the green arrow, GAPDH serves as a control and appears in red arrow.








    RNA Targets
    • DDX59 protein binds to 3,060 RNA regions.  





    Proteins bound to RNA
    • DDX59 RNA is bound by 2 proteins.  






    DDX59 protein has 3,060 RNA targets:

    Only display 100 entries as example. Please click "View All" button to see all 3,060 entries.     

    RBP Chr Start End Strand log2(fold change) -log(p-value) Cell Line Matched Gene Matched Area
    DDX59chr174322062843220709+3.432875.40117HepG2ACBD4intron-Distal
    DDX59chrX129147914129147968+5.098475.41835HepG2BCORL1CDS
    DDX59chr1918849271885017-3.477963.32762HepG2ABHD17Aintron-Distal
    DDX59chr177611205776112091-4.748253.97933HepG2TMC6intron-Distal
    DDX59chr12133117742133117771+4.656214.35687HepG2FBRSL1intron-Distal
    DDX59chr53900675839006822-4.634546.62251HepG2RICTORintron-Distal
    DDX59chr12112015495112015569-4.359443.44037HepG2ATXN2intron-Distal
    DDX59chr9139722576139722642+3.569029.35115HepG2RP11-216L13.18, RABL6intron-Distal
    DDX59chr224703152647031569+4.201693.23168HepG2GRAMD4intron-Distal
    DDX59chr13113368159113368245+5.6653351.02030HepG2ATP11Aintron-Distal
    DDX59chr206089320960893281-5.979338.21335HepG2LAMA5intron-Distal
    DDX59chr111083025010830298-5.75330400.00000HepG2EIF4G25'-UTR,intron-Distal,intron-Proximal
    DDX59chr748297654829863+4.207689.47975HepG2AP5Z1CDS,intron-Distal,intron-Proximal
    DDX59chr2129050234129050283-3.448215.17241HepG2HS6ST1intron-Distal
    DDX59chr5138918023138918081+3.393003.70770HepG2UBE2D2intron-Distal
    DDX59chr168997398689974037+5.5879937.96815HepG2RP11-566K11.7, TCF25intron-Distal
    DDX59chr4668540668600+4.520413.23168HepG2MYL55'-UTR,intron-Distal,intron-Proximal
    DDX59chr167002428270024331-3.275895.02497HepG2RP11-419C5.2, PDXDC2Pintron-Distal
    DDX59chr1204330931204330973-4.359443.44037HepG2PLEKHA6intron-Distal
    DDX59chr7143087860143087931+3.0853310.81505HepG2ZYX3'-UTR
    DDX59chr2134909314134909354+3.690935.17241HepG2MGAT5intron-Distal
    DDX59chr17169648169714-4.664693.92947HepG2RPH3ALintron-Distal
    DDX59chr163075997530760129+4.8963210.06682HepG2RP11-2C24.4, PHKG25'-UTR,intron-Distal,intron-Proximal
    DDX59chr161461305514613162-5.5407324.75468HepG2PARNintron-Distal
    DDX59chr8145065674145065700+5.6076627.93997HepG2GRINACDS
    DDX59chr194240183842401873+3.762538.69176HepG2ARHGEF1intron-Distal
    DDX59chr3128050130128050245+5.876949.78105HepG2EEFSECintron-Distal
    DDX59chr125719352572002-5.2397511.11180HepG2TTC34intron-Distal
    DDX59chr93582947935829634+5.3151821.70350HepG2TMEM8B5'-UTR,intron-Distal,intron-Proximal
    DDX59chr19871704871783-3.995958.31277HepG2MED16intron-Distal,intron-Proximal
    DDX59chr1913959631396027-3.506266.08418HepG2AC005329.7intron-Distal
    DDX59chr5154137273154137303+3.748255.96063HepG2LARP1intron-Distal
    DDX59chr125384851153848572+4.73052400.00000HepG2PCBP23'-UTR,5'-UTR
    DDX59chr177887250378872533+4.494183.92947HepG2RPTORintron-Distal
    DDX59chr104389210343892172-4.2777016.74963HepG2HNRNPF5'-UTR,intron-Distal,intron-Proximal
    DDX59chr173674938636749434-4.185483.44037HepG2SRCIN1intron-Distal
    DDX59chr93326547533265532+3.444413.32156HepG2CHMP5intron-Distal
    DDX59chr110769231077036+6.1422012.54389HepG2RP11-465B22.5intron-Distal
    DDX59chr213862999838630090-4.415203.60414HepG2DSCR3intron-Distal
    DDX59chr9137316027137316112+4.217556.62251HepG2RXRAintron-Distal
    DDX59chr710285371028564+4.8835339.68246HepG2CYP2W13'-UTR
    DDX59chr12748107327481168-3.7279310.11557HepG2SLC9A15'-UTR,intron-Distal,intron-Proximal
    DDX59chr20327781327825-4.651934.73643HepG2RP5-1103G7.4intron-Distal
    DDX59chr5176918185176918303-3.787256.94360HepG2PDLIM7intron-Distal,intron-Proximal
    DDX59chr11793854317938626+3.5106711.86189HepG2ARHGEF10Lintron-Distal
    DDX59chr206257998462580033-5.5704425.98099HepG2UCKL1intron-Distal
    DDX59chr133013150230131536-4.494183.92947HepG2SLC7A1intron-Distal
    DDX59chr1771549227154987-6.99523400.00000HepG2CTDNEP1, RP1-4G17.55'-UTR,intron-Distal,intron-Proximal
    DDX59chr177611164976111726-5.8281830.89878HepG2TMC6intron-Distal
    DDX59chr7158188814158188885-4.2953717.70797HepG2PTPRN2intron-Distal
    DDX59chr77561789575617943-4.929954.35687HepG2TMEM120Aintron-Distal,intron-Proximal
    DDX59chr1916419591642044-4.248253.44037HepG2TCF3intron-Distal
    DDX59chr172707275127072811+3.8391213.91130HepG2TRAF4intron-Distal
    DDX59chr1620567712056859-4.581848.39471HepG2ZNF598intron-Distal
    DDX59chr191535079715350831-4.409216.20526HepG2BRD4CDS,intron-Distal
    DDX59chr16188278188337-3.898457.36309HepG2NPRL35'-UTR,intron-Distal,intron-Proximal
    DDX59chr1270249467024997+3.954517.30395HepG2ENO23'-UTR,5'-UTR,intron-Proximal
    DDX59chr12856333028563381+3.494183.32156HepG2ATPIF13'-UTR,intron-Distal
    DDX59chr194240138842401457+5.1527326.44752HepG2ARHGEF1intron-Distal,intron-Proximal
    DDX59chr19912891912938-6.5677717.31695HepG2R3HDM4intron-Distal
    DDX59chr187482979274829838-5.070186.92952HepG2MBPintron-Distal
    DDX59chr206258033162580423-3.9953727.37620HepG2UCKL1intron-Distal
    DDX59chr11130184489130184563-3.932876.89237HepG2ZBTB445'-UTR,intron-Distal,intron-Proximal
    DDX59chr194275873842758819-3.2501210.35948HepG2AC006486.9, ERF5'-UTR,intron-Distal,intron-Proximal
    DDX59chr2084690458469082+4.966954.42259HepG2PLCB1intron-Distal
    DDX59chr168568392185683955+3.448215.17241HepG2GSE1intron-Distal
    DDX59chr204832930848329354-4.454519.27196HepG2B4GALT5intron-Distal
    DDX59chr107563377575633842-4.598474.35687HepG2CAMK2Gintron-Distal
    DDX59chr20401080401099+5.67848400.00000HepG2RBCK1intron-Distal
    DDX59chr2242756745242756816+4.7885824.40068HepG2NEU4intron-Distal,intron-Proximal
    DDX59chr2159313968159314016+4.381646.94678HepG2PKP45'-UTR,intron-Distal
    DDX59chr187768265277682681-3.694655.95859HepG2PQLC1intron-Distal
    DDX59chr77428265874282766-3.529513.70770HepG2STAG3L2intron-Distal
    DDX59chr82288559822885658-3.570189.90816HepG2TNFRSF10Bintron-Distal
    DDX59chr117240055572400601-4.415203.60414HepG2ARAP1intron-Distal,intron-Proximal
    DDX59chr7767299767398+4.625698.82475HepG2HEATR2intron-Distal
    DDX59chr193966486539664900+3.535703.67675HepG2PAK4intron-Distal
    DDX59chr214805603848056228+3.6678617.98742HepG2PRMT25'-UTR,intron-Distal
    DDX59chr47904032379040419+3.538328.52841HepG2FRAS1intron-Distal
    DDX59chr1948516114851693-4.664693.92947HepG2PLIN3intron-Distal
    DDX59chr203421818334218205-3.417184.59303HepG2CPNE1intron-Distal
    DDX59chr1913960271396114-4.6142213.24181HepG2AC005329.7intron-Distal
    DDX59chr112598811259932-3.559718.36295HepG2CPSF3Lintron-Distal
    DDX59chr214773861547738694-3.983415.65933HepG2C21orf585'-UTR,intron-Distal,intron-Proximal
    DDX59chr3196538064196538135+6.1813713.60442HepG2PAK2intron-Distal
    DDX59chr7157791633157791716-3.955774.74496HepG2PTPRN2intron-Distal
    DDX59chr296779549678069-5.8464510.50585HepG2ADAM17intron-Distal
    DDX59chr1270248837024930+3.105373.25495HepG2ENO25'-UTR,intron-Distal,intron-Proximal
    DDX59chr76414052564140574+3.748253.32762HepG2ZNF107intron-Distal
    DDX59chr5138918091138918132+4.444413.92947HepG2UBE2D2intron-Distal
    DDX59chr177885320578853279+6.0274614.12285HepG2RPTORintron-Distal
    DDX59chr7158188596158188665-5.8309123.61393HepG2PTPRN2intron-Distal
    DDX59chr195436976954369869+3.123464.44773HepG2MYADMintron-Distal,intron-Proximal
    DDX59chr6157468737157468779+4.070184.70992HepG2ARID1Bintron-Distal
    DDX59chr149999432499994407-3.598473.67675HepG2CCDC85Cintron-Distal
    DDX59chr1205172523205172660-3.944415.47084HepG2DSTYKintron-Distal
    DDX59chr13113537301113537353+6.3644871.24705HepG2ATP11A3'-UTR
    DDX59chr191422789714227997-3.089164.52901HepG2PRKACAintron-Distal
    DDX59chr12133138940133139032+3.305994.59303HepG2FBRSL1intron-Distal
    DDX59chr161847528318475368-5.062934.91906HepG2RP11-1212A22.1, PKD1P5intron-Distal




    2 proteins are bound to DDX59 RNA:

    Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
    chr1200613301200613348-3'-UTR,intron-Distal4.643995.09993K562PUM2
    chr1200635140200635283-CDS,intron-Distal3.372707.36929K562YBX3
    ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




    No autoregularoty interactions between protein DDX59 and its RNA.



    Diffrential Expression
    • 3,201 differentially expressed genes after Knockdown/Knockout DDX59 protein.  





    • 45 RBPs can affect the levels of DDX59.  







    3,201 differentially expressed genes after Knockdown/Knockout DDX59 protein :

    Only display 100 entries as example. Please click "View All" button to see all 3,201 entries.     

    Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
    C1orf112ENSG00000000460.12118.52690244.28390-1.043304.669803.41100HepG2DDX59
    GCLCENSG00000001084.62245.119701419.554500.661303.897802.74780HepG2DDX59
    NFYAENSG00000001167.101005.589602013.77810-1.001907.989906.37580HepG2DDX59
    LAS1LENSG00000001497.12517.62700771.88030-0.576502.603701.65710HepG2DDX59
    ANKIB1ENSG00000001629.51793.456101009.322100.829305.633304.25200HepG2DDX59
    CD99ENSG00000002586.134542.219902768.515700.714204.529703.28850HepG2DDX59
    LASP1ENSG00000002834.1313349.778507367.837100.857406.636405.15520HepG2DDX59
    CASP10ENSG00000003400.10756.99290335.911801.172108.556106.89490HepG2DDX59
    TFPIENSG00000003436.1017776.382608632.413801.042003.851002.70670HepG2DDX59
    PLXND1ENSG00000004399.84515.370102490.240500.858504.671003.41150HepG2DDX59
    RECQLENSG00000004700.11416.77370963.73370-1.209409.544607.80360HepG2DDX59
    DVL2ENSG00000004975.7301.21780555.53530-0.883103.635702.51780HepG2DDX59
    DHX33ENSG00000005100.8981.454001524.86760-0.635703.473202.37970HepG2DDX59
    AC004381.6ENSG00000005189.1581.98400182.97270-1.158204.595803.34740HepG2DDX59
    MSL3ENSG00000005302.13511.72560330.143200.632202.225701.35190HepG2DDX59
    CROTENSG00000005469.7541.25480235.065501.203108.232606.59800HepG2DDX59
    RHBDD2ENSG00000005486.12882.95520489.360400.851302.486301.56040HepG2DDX59
    ITGA3ENSG00000005884.13106.23000358.70730-1.755605.169703.84610HepG2DDX59
    GDE1ENSG00000006007.73672.440602210.383500.732304.781403.50840HepG2DDX59
    CX3CL1ENSG00000006210.63569.521101874.860800.928802.307901.41750HepG2DDX59
    MAP3K9ENSG00000006432.111192.39440714.188600.739404.343603.13200HepG2DDX59
    BAIAP2L1ENSG00000006453.92043.66990982.795201.056108.801207.11700HepG2DDX59
    JHDM1DENSG00000006459.62348.108301312.256400.839305.758204.36550HepG2DDX59
    ALDH3B1ENSG00000006534.1150.85690132.80370-1.384804.993203.69410HepG2DDX59
    DBF4ENSG00000006634.3631.071501098.28810-0.799403.438102.35120HepG2DDX59
    IFRD1ENSG00000006652.91065.50930738.396800.529002.516001.58470HepG2DDX59
    PROM1ENSG00000007062.7755.79730528.613900.515702.224001.35080HepG2DDX59
    CCDC124ENSG00000007080.6295.19570508.13760-0.783503.908802.75790HepG2DDX59
    PAX6ENSG00000007372.16225.1736082.974501.440207.560205.98650HepG2DDX59
    BAIAP3ENSG00000007516.9137.7601070.983300.956502.972401.96060HepG2DDX59
    TEAD3ENSG00000007866.14780.353701161.80670-0.574202.720101.75090HepG2DDX59
    SYPL1ENSG00000008282.31602.903701145.688600.484402.229901.35540HepG2DDX59
    CYB561ENSG00000008283.1113.1175057.74810-2.138304.910003.62230HepG2DDX59
    CELSR3ENSG00000008300.101074.00270724.650500.567502.714301.74680HepG2DDX59
    MGST1ENSG00000008394.81451.922902407.83240-0.729804.514503.27530HepG2DDX59
    ST3GAL1ENSG00000008513.101505.67890964.863400.641903.468602.37650HepG2DDX59
    MAPK8IP2ENSG00000008735.10483.3825095.360802.3416023.1262020.63010HepG2DDX59
    MLXIPLENSG00000009950.113098.582404433.82200-0.516902.745501.77140HepG2DDX59
    METTL13ENSG00000010165.15269.64690410.23240-0.605402.304101.41470HepG2DDX59
    NCAPD2ENSG00000010292.81176.293102982.31030-1.3422012.3967010.41700HepG2DDX59
    SEMA3GENSG00000010319.2839.67670367.245601.193009.066207.36450HepG2DDX59
    IDSENSG00000010404.131743.190201032.852300.755004.799403.52460HepG2DDX59
    LRRC23ENSG00000010626.1028.7886068.94690-1.260002.714201.74680HepG2DDX59
    HFEENSG00000010704.1436.5030079.58030-1.124402.624701.67460HepG2DDX59
    HIVEP2ENSG00000010818.42184.86980902.588701.2753012.0968010.14970HepG2DDX59
    CLCN6ENSG00000011021.172370.600601373.059200.787805.132603.81330HepG2DDX59
    BTBD7ENSG00000011114.10706.390301027.92930-0.541202.538201.60340HepG2DDX59
    AKAP8LENSG00000011243.131938.433201319.212800.555102.790801.80810HepG2DDX59
    UTP18ENSG00000011260.9377.48840563.22720-0.577302.490301.56330HepG2DDX59
    TTC19ENSG00000011295.11320.91970567.35740-0.822004.330203.12170HepG2DDX59
    PTBP1ENSG00000011304.123779.537605670.56900-0.585303.341602.26870HepG2DDX59
    SYT7ENSG00000011347.5603.30660164.872801.8714017.3336015.10490HepG2DDX59
    LARS2ENSG00000011376.5565.05690919.67120-0.702703.778402.64200HepG2DDX59
    ANLNENSG00000011426.61220.627103516.52930-1.5265018.0328015.77460HepG2DDX59
    MAP4K3ENSG00000011566.105124.648902998.721800.773003.300002.23500HepG2DDX59
    BRCA1ENSG00000012048.15707.302801665.70480-1.2357011.340609.43760HepG2DDX59
    ERCC1ENSG00000012061.11198.91220357.57450-0.846103.783402.64640HepG2DDX59
    EXTL3ENSG00000012232.4337.35770678.72470-1.008506.291304.84450HepG2DDX59
    NR1H4ENSG00000012504.9199.23450813.39400-2.0295022.0890019.63210HepG2DDX59
    CLDN11ENSG00000013297.6257.05320148.697900.789603.163102.11800HepG2DDX59
    HEBP1ENSG00000013583.4302.51980465.26560-0.621002.643801.69010HepG2DDX59
    TACC3ENSG00000013810.14345.124901201.73690-1.7999020.2721017.89350HepG2DDX59
    POLA2ENSG00000014138.4132.89450303.84270-1.193006.275404.83180HepG2DDX59
    MDH1ENSG00000014641.13232.767201343.53490-2.5291036.3451033.30200HepG2DDX59
    SLC38A5ENSG00000017483.10565.83590966.16500-0.771904.472403.23930HepG2DDX59
    RUFY3ENSG00000018189.8684.43000434.327000.656003.099702.06590HepG2DDX59
    WWTR1ENSG00000018408.104014.180202295.729900.806105.649804.26720HepG2DDX59
    CD74ENSG00000019582.101909.714202671.40650-0.484202.275101.39150HepG2DDX59
    SAMD4AENSG00000020577.91250.36030884.208600.499802.248901.37060HepG2DDX59
    PLEKHB1ENSG00000021300.91429.406702171.92140-0.603603.315602.24770HepG2DDX59
    FHL1ENSG00000022267.1211.114900.509104.448402.529701.59640HepG2DDX59
    RB1CC1ENSG00000023287.82500.542201788.723400.483202.256101.37630HepG2DDX59
    ABCC2ENSG00000023839.68523.454504587.047200.893807.058505.53510HepG2DDX59
    PLEKHO1ENSG00000023902.9299.12090172.622400.793002.554301.61630HepG2DDX59
    EHD2ENSG00000024422.7132.4506048.189401.458605.307503.96700HepG2DDX59
    DEPDC1ENSG00000024526.12173.21380686.58670-1.9869020.4799018.09220HepG2DDX59
    RRAGDENSG00000025039.105.2416025.45220-2.279702.763001.78520HepG2DDX59
    MIPEPENSG00000027001.7200.84680315.21090-0.650202.452301.53250HepG2DDX59
    HMGB3ENSG00000029993.10741.818501550.60180-1.063708.547906.88840HepG2DDX59
    SARSENSG00000031698.83286.603001954.500600.749705.045003.73730HepG2DDX59
    IFT88ENSG00000032742.13202.49990354.18120-0.806603.595402.48340HepG2DDX59
    ALG1ENSG00000033011.7547.06100849.70710-0.635303.095902.06340HepG2DDX59
    GAB2ENSG00000033327.8952.31750542.074700.812904.926003.63580HepG2DDX59
    ATP6V0A1ENSG00000033627.102296.086201581.146700.538102.784201.80260HepG2DDX59
    SLC4A7ENSG00000033867.121492.951601056.039800.499402.317801.42580HepG2DDX59
    APBA2ENSG00000034053.1035.0514083.59620-1.254003.176402.12970HepG2DDX59
    UHRF1ENSG00000034063.91061.192202175.25520-1.035508.509606.85440HepG2DDX59
    RNF19AENSG00000034677.72615.09200916.900501.5119016.7368014.53870HepG2DDX59
    DEPDC1BENSG00000035499.8287.09190578.32910-1.010406.116204.69040HepG2DDX59
    NSMAFENSG00000035681.3580.45770940.65580-0.696503.821402.68000HepG2DDX59
    TIMP2ENSG00000035862.85102.751902918.530500.805903.759602.62600HepG2DDX59
    NSUN2ENSG00000037474.101229.568402064.84880-0.747904.799803.52470HepG2DDX59
    METTL1ENSG00000037897.12180.60590376.07060-1.058205.740904.35010HepG2DDX59
    MAT2BENSG00000038274.12285.96260489.36140-0.775103.663302.54170HepG2DDX59
    VCANENSG00000038427.111977.046704722.07890-1.256102.817101.83070HepG2DDX59
    DNAH5ENSG00000039139.953.584806.787302.980803.169002.12340HepG2DDX59
    RAI14ENSG00000039560.91833.665101226.287400.580302.477601.55340HepG2DDX59
    PHLPP2ENSG00000040199.141490.26450615.037901.2767011.596709.67380HepG2DDX59
    SPDL1ENSG00000040275.12262.97940691.16780-1.3941011.387509.48150HepG2DDX59
    CTNSENSG00000040531.10250.95200387.60820-0.627202.384201.47740HepG2DDX59
    Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

    *: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
    **: "-log(0)" was displayed as "99999.99999".





    45 RBPs can affect the gene expression of DDX59 :

    Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
    DDX59ENSG00000118197.9497.80230374.211100.411601.853501.40850HepG2AKAP1
    DDX59ENSG00000118197.9373.67300469.76250-0.330202.019801.41620HepG2AUH
    DDX59ENSG00000118197.9123.91650329.57820-1.411308.533406.87640HepG2DDX59
    DDX59ENSG00000118197.9228.19930299.50780-0.392301.941001.35870HepG2DKC1
    DDX59ENSG00000118197.9137.06860281.50460-1.0383010.106508.95440HepG2DNAJC2
    DDX59ENSG00000118197.9238.25040316.84580-0.411302.374701.81010HepG2HNRNPU
    DDX59ENSG00000118197.9380.94730518.10150-0.443602.048601.34280HepG2LARP4
    DDX59ENSG00000118197.9188.52840274.43800-0.541702.399901.34730HepG2LARP7
    DDX59ENSG00000118197.9227.20680330.13770-0.539102.550201.91900HepG2MAGOH
    DDX59ENSG00000118197.9228.23940332.00490-0.540702.369101.78210HepG2MATR3
    DDX59ENSG00000118197.9256.85620347.45090-0.435802.631802.09620HepG2PTBP1
    DDX59ENSG00000118197.9322.20060415.97210-0.368501.842601.34250HepG2PUF60
    DDX59ENSG00000118197.9320.29680441.57730-0.463303.758403.09000HepG2PUM1
    DDX59ENSG00000118197.9464.50220279.132400.734603.413502.63250HepG2RAVER1
    DDX59ENSG00000118197.9282.66910386.67050-0.452002.701002.16480HepG2NELFE
    DDX59ENSG00000118197.9409.05250310.817600.396101.963301.36290HepG2SF3B1
    DDX59ENSG00000118197.9231.28130329.06360-0.508703.510102.79960HepG2SMN1
    DDX59ENSG00000118197.9413.03040509.15910-0.301901.969501.52520HepG2SRFBP1
    DDX59ENSG00000118197.9280.11210410.71730-0.552104.246803.50030HepG2SRSF5
    DDX59ENSG00000118197.9240.14760307.17780-0.355201.821901.35650HepG2SRSF9
    DDX59ENSG00000118197.9311.55690442.06970-0.504804.013203.42010HepG2SSB
    DDX59ENSG00000118197.9220.98530307.90010-0.478502.542502.05940HepG2TIAL1
    DDX59ENSG00000118197.9170.47960310.62540-0.865607.666106.80450HepG2TRIM56
    DDX59ENSG00000118197.9488.33710345.855400.497602.653702.03750HepG2U2AF1
    DDX59ENSG00000118197.9254.65520430.16710-0.756404.305403.24830HepG2UBE2L3
    DDX59ENSG00000118197.9261.70170339.22550-0.374302.085001.46440HepG2UPF1
    DDX59ENSG00000118197.9951.32350616.864300.624902.396501.41960K562CNOT7
    DDX59ENSG00000118197.9290.55170413.08810-0.507703.230102.34590K562EIF4A3
    DDX59ENSG00000118197.9309.79670429.59230-0.471603.348502.69160K562FXR1
    DDX59ENSG00000118197.9381.51960500.46960-0.391502.268601.72060K562HNRNPC
    DDX59ENSG00000118197.9463.00800635.27380-0.456303.459802.26100K562HNRNPL
    DDX59ENSG00000118197.9877.48300660.837600.409002.768701.97360K562HSPD1
    DDX59ENSG00000118197.9300.89450472.26160-0.650305.472604.27730K562MAGOH
    DDX59ENSG00000118197.9321.94110471.32330-0.549904.237103.07440K562MATR3
    DDX59ENSG00000118197.9543.22760420.099000.370702.131001.36170K562METAP2
    DDX59ENSG00000118197.9301.16170532.64670-0.822602.737401.75480K562PABPN1
    DDX59ENSG00000118197.9232.59110348.91850-0.585103.819902.87240K562POLR2G
    DDX59ENSG00000118197.9195.17960299.89610-0.619702.912302.14410K562PRPF8
    DDX59ENSG00000118197.9326.91990448.74250-0.457002.366401.53650K562PSIP1
    DDX59ENSG00000118197.9294.76710458.82200-0.638405.457404.55220K562PTBP1
    DDX59ENSG00000118197.9718.04490905.89720-0.335301.873401.40950K562PUS1
    DDX59ENSG00000118197.9677.01600882.77960-0.382902.315701.76520K562RBM15
    DDX59ENSG00000118197.9333.55720440.02640-0.399702.235301.48400K562RBM22
    DDX59ENSG00000118197.9294.70350409.51130-0.474602.963901.93610K562RCC2
    DDX59ENSG00000118197.9350.95120491.38010-0.485603.616802.63480K562SF3B4
    DDX59ENSG00000118197.9301.29060449.78400-0.578104.266403.39500K562SRSF1
    DDX59ENSG00000118197.9335.75890455.24210-0.439202.505101.82920K562TARDBP
    DDX59ENSG00000118197.9296.39610431.60410-0.542203.049902.06210K562TIAL1
    DDX59ENSG00000118197.9338.70400458.62610-0.437302.360401.49810K562TRIM56
    DDX59ENSG00000118197.9616.72620464.197600.409802.866901.97400K562WDR3
    Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

    *: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
    **: "-log(0)" was displayed as "99999.99999".





    481 alternative splicing events after Knockdown/Knockout DDX59 protein :

    Only display 100 entries as example. Please click "View All" button to see all 481 entries.     

    Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
    SEILF3ENSG00000129351.13chr19+1079802110798384107945921079464610799225107993540.093000.000240.02963includedHepG2DDX59
    SESNRNP70ENSG00000104852.10chr19+4960537049606844496046464960472849607890496079920.065000.000000.00009includedHepG2DDX59
    SEMETTL21AENSG00000144401.10chr2-2084853642084854182084774462084781672084865292084866410.095000.000970.08505includedHepG2DDX59
    SELUC7L3ENSG00000108848.11chr17+4882657948826705488239024882406348827861488282080.052000.000630.05919includedHepG2DDX59
    SETOP1MTENSG00000184428.8chr8-1444162771444164551444133931444135091444169091444169650.168000.000040.00723includedHepG2DDX59
    SECRELD1ENSG00000163703.13chr3+9979245997935699765189976601998253399827100.334000.000300.03538includedHepG2DDX59
    SEPIGXENSG00000163964.9chr3+1964535251964536421964492851964494271964547931964549080.197000.000010.00164includedHepG2DDX59
    SETIMM8BENSG00000150779.7chr11-1119567011119570341119555231119561861119573631119575220.126000.000090.01437includedHepG2DDX59
    SENRIP1ENSG00000180530.5chr21-1638666416386787163635211636362716415815164158950.211000.000100.01555includedHepG2DDX59
    SENKTRENSG00000114857.13chr3+4266150742661535426611554266120042662920426630080.484000.000000.00012includedHepG2DDX59
    SEDPM1ENSG00000000419.8chr20-4955764149557746495574014955747049558567495586630.067000.000000.00103includedHepG2DDX59
    SEITGA2ENSG00000164171.6chr5+5236894752369089523684425236852552370214523703070.051000.000140.02056includedHepG2DDX59
    SETNS4ENSG00000131746.8chr17-3863517338635270386348313863490038635925386360940.169000.000530.05349includedHepG2DDX59
    SEALDOAENSG00000149925.12chr16+3007719630077248300760593007610530078554300786870.079000.000000.00134includedHepG2DDX59
    SEZCCHC6ENSG00000083223.13chr9-8891665488916743889161908891651688918000889181160.061000.000000.00131includedHepG2DDX59
    SETPM1ENSG00000140416.15chr15+6335391163353987633532346335347263354413633544760.074000.000160.02304includedHepG2DDX59
    SEEIF2B5ENSG00000145191.7chr3+1838566341838567271838559531838560341838578671838579450.082000.000100.01559includedHepG2DDX59
    SEPCNPENSG00000081154.7chr3+1013042801013043551012930371012931231013090581013091140.063000.000240.02963includedHepG2DDX59
    SEPAPD4ENSG00000164329.9chr5+7891029478910383789088337890889878915434789156080.146000.000050.00897includedHepG2DDX59
    SEKLF3ENSG00000109787.8chr4+3868958338689807386822073868230338690205386906920.137000.000280.03334includedHepG2DDX59
    SEFAM126AENSG00000122591.7chr7-2298657022986866229808872298578222999874230000340.242000.000000.00090includedHepG2DDX59
    SETRA2AENSG00000164548.6chr7-2356173923562051235613252356145923571407235715990.132000.000230.02928includedHepG2DDX59
    SEMYH10ENSG00000133026.8chr17-8479960847999084730378473130848055384806560.058000.000220.02798includedHepG2DDX59
    SESEC31AENSG00000138674.12chr4-8375208983752128837501528375021183763292837636340.267000.000000.00000includedHepG2DDX59
    SEWNK1ENSG00000060237.12chr12+9770319782709712489714369804309805140.117000.000000.00001includedHepG2DDX59
    SERHOT1ENSG00000126858.12chr17+3049995530500079304980613049812030500849305009310.190000.000010.00289includedHepG2DDX59
    SEPICALMENSG00000073921.13chr11-8568896085689136856876658568772585692171856922710.175000.000170.02391includedHepG2DDX59
    SEZNF207ENSG00000010244.12chr17+3069368330693776306923483069250630694790306950330.162000.000000.00000includedHepG2DDX59
    SEACIN1ENSG00000100813.10chr14-2355919023559310235509562355104523559730235598420.176000.000000.00028includedHepG2DDX59
    SEZNF687ENSG00000143373.13chr1+1512576811512585501512547871512548711512587501512608820.210000.000560.05527includedHepG2DDX59
    SECLCN3ENSG00000109572.9chr4+1706389421706390181706342291706344461706410571706416960.125000.000290.03380includedHepG2DDX59
    SENOL8ENSG00000198000.7chr9-9508222495082419950815029508163895083949950840280.147000.000000.00122includedHepG2DDX59
    SEWARSENSG00000140105.13chr14-1008416191008417431008280441008282581008425961008426460.127000.000430.04430includedHepG2DDX59
    SEPHACTR4ENSG00000204138.8chr1+2871935228719452286961132869633628733920287339740.079000.000600.05768includedHepG2DDX59
    SERPL32P3ENSG00000251474.2chr3-1291150591291152631291124771291126381291158821291159830.104000.000570.05527includedHepG2DDX59
    SEZNF384ENSG00000126746.13chr12-6786332678642567823816782606678729267876260.056000.000010.00320includedHepG2DDX59
    SEMAGI1ENSG00000151276.19chr3-6536141965361587653505276535062165364935653652290.132000.000150.02056includedHepG2DDX59
    SEFIGNL1ENSG00000132436.7chr7-5051566550515753505148805051499550515878505159870.088000.000220.02869includedHepG2DDX59
    SEKIAA1109ENSG00000138688.11chr4+1232376171232377031232366161232368431232378861232379490.052000.000990.08625includedHepG2DDX59
    SEDNAJA3ENSG00000103423.9chr16+4504811450492844995544500498450554645067730.094000.001200.09852includedHepG2DDX59
    SESMPDL3AENSG00000172594.8chr6+1231273771231275021231260531231262341231302351231308650.186000.000010.00173includedHepG2DDX59
    SEFAM204AENSG00000165669.9chr10-1201012381201014601200955361200959351201017811201018320.355000.000490.05003includedHepG2DDX59
    SEC4orf32ENSG00000174749.5chr4+1131018291131020141130665521130668891131078481131164120.228000.000270.03255includedHepG2DDX59
    SEABCC2ENSG00000023839.6chr10+1015565311015566101015541691015542251015568531015578530.117000.000000.00000includedHepG2DDX59
    SEABCC2ENSG00000023839.6chr10+1015768201015769531015727741015729011015770641015772410.150000.000430.04430includedHepG2DDX59
    SEMLXIPLENSG00000009950.11chr7-7302023973020441730200177302009873030400730305070.059000.000070.01149includedHepG2DDX59
    SEMADDENSG00000110514.14chr11+4729537747295527472912434729145747296113472964560.139000.000070.01187includedHepG2DDX59
    SEMST1ENSG00000173531.11chr3-4972349449723625497232924972339549723745497239000.314000.001080.09156includedHepG2DDX59
    SETRAPPC12ENSG00000171853.11chr2+3460920346100034475493447662346139134614640.227000.000000.00062includedHepG2DDX59
    SEBPTFENSG00000171634.12chr17+6587167165871860658709326587113665887959658881500.231000.000100.01503includedHepG2DDX59
    SEPLXND1ENSG00000004399.8chr3-1292784621292786261292772701292774181292791721292792770.086000.000080.01322includedHepG2DDX59
    SEWSB1ENSG00000109046.10chr17+2563476925634945256338072563390825636125256362980.313000.000000.00001includedHepG2DDX59
    SENSMCE2ENSG00000156831.3chr8+1261682411261683401261634121261635191261943441261946720.196000.000000.00058includedHepG2DDX59
    SEFRG1ENSG00000109536.7chr4+1908630631908631591908620241908622261908643561908644270.085000.000030.00583includedHepG2DDX59
    SEHNRNPDLENSG00000152795.13chr4-8334671583346820833457818334603683347189833472820.165000.000000.00000includedHepG2DDX59
    SEUSP25ENSG00000155313.11chr21+1715022217150346171383151713846017163820171639830.153000.000000.00003includedHepG2DDX59
    SESRSF2ENSG00000161547.10chr17-7473185374731957747302287473124074732235747326370.101000.000000.00001includedHepG2DDX59
    SELARP4BENSG00000107929.10chr10-8905828907188888718890088909168909950.270000.000280.03292includedHepG2DDX59
    SEMBNL2ENSG00000139793.14chr13+9801871298018807980097359800988998043575980463740.093000.000340.03858includedHepG2DDX59
    SEUPF3AENSG00000169062.10chr13+1150517031150518751150483111150484181150519931150521040.163000.000610.05807includedHepG2DDX59
    SEDMTNENSG00000158856.13chr8+2192459521924670219243482192440421925037219251930.062000.000190.02541includedHepG2DDX59
    SECOBLL1ENSG00000082438.11chr2-1655836151655836541655789341655790321655844781655847070.089000.000020.00518includedHepG2DDX59
    SEU2AF1ENSG00000160201.7chr21-4452056244520629445158034451585344521475445215420.111000.000330.03800includedHepG2DDX59
    SEFDPSENSG00000160752.10chr1+1552795791552797561552786421552787561552798331552799750.130000.000000.00050includedHepG2DDX59
    SERPL31ENSG00000071082.6chr2+1016354591016356621016224201016225331016400861016404940.501000.000010.00148includedHepG2DDX59
    SEHADHENSG00000138796.11chr4+1089490941089492251089486671089489161089543311089544480.091000.000190.02556includedHepG2DDX59
    SERNASE4ENSG00000258818.2chr14+2116170521161809211528172115291721167513211687100.106000.001010.08762includedHepG2DDX59
    SENDUFS1ENSG00000023228.9chr2-2070171422070172342070145412070146492070183412070184060.066000.000490.04955includedHepG2DDX59
    SEKAT6AENSG00000083168.5chr8-4181456641814698418128134181292941832221418323400.246000.000360.03981includedHepG2DDX59
    SEPCM1ENSG00000078674.13chr8+1784074117840798178380991783826417842955178431280.076000.000410.04299includedHepG2DDX59
    SEHRASENSG00000174775.12chr11-5332765333585322415327555334525336120.121000.000110.01660includedHepG2DDX59
    SEPLSCR1ENSG00000188313.8chr3-1462543261462543521462512561462513371462622531462623420.147000.000000.00004includedHepG2DDX59
    SESEC22BENSG00000223380.3chr1+1451039341451040171450965301450966211451095231451096840.080000.000020.00451includedHepG2DDX59
    SEFANCAENSG00000187741.10chr16-8986535889865506898623138986242689865573898656400.379000.000950.08345includedHepG2DDX59
    SEAGPSENSG00000018510.8chr2+1783068471783069631783056921783057641783071341783072140.086000.000000.00002includedHepG2DDX59
    SESNHG14ENSG00000224078.8chr15+2535084625350971253490052534911725351310253514410.199000.000000.00003includedHepG2DDX59
    SEGPR126ENSG00000112414.10chr6+1427620441427620901427593481427595011427644731427674030.100000.000680.06277includedHepG2DDX59
    SESTAT6ENSG00000166888.6chr12-5750372357503893575019455750208257504911575051960.208000.000360.03981includedHepG2DDX59
    SEUQCRHENSG00000173660.7chr1+4677556846775716467747724677479946775826467759880.295000.000010.00159includedHepG2DDX59
    SERAPGEF1ENSG00000107263.14chr9-1345255151345256291345186251345188041345261961345263360.236000.000030.00643includedHepG2DDX59
    SELSM14AENSG00000257103.4chr19+3471029534710478347065003470656634710610347107820.073000.000110.01643includedHepG2DDX59
    SECTC-432M15.3ENSG00000273217.1chr5-1307857151307857391307821751307823961307887461307888700.221000.000400.04245includedHepG2DDX59
    SEF2ENSG00000180210.10chr11+4675092946751111467502134675038746760597467606680.055000.000020.00467includedHepG2DDX59
    SEC8orf59ENSG00000176731.7chr8-8613146486131592861296148612973186132534861326130.209000.000000.00045includedHepG2DDX59
    SEEEF2KENSG00000103319.7chr16+2226896322269091222685732226870622269814222700160.144000.000470.04784includedHepG2DDX59
    SEASPHENSG00000198363.11chr8-6255650362556560625559446255599262557158625571910.083000.000070.01149includedHepG2DDX59
    SEGDAP2ENSG00000196505.6chr1-1184203671184204631184061061184132381184206301184207370.180000.000020.00525includedHepG2DDX59
    SEABCA7ENSG00000064687.8chr19+1057913105805810573121057428105814410582680.167000.001070.09133includedHepG2DDX59
    SEABI1ENSG00000136754.12chr10-2704799027048167270405262704071227054146270542470.074000.000190.02551includedHepG2DDX59
    SESORBS2ENSG00000154556.13chr4-1865729371865729821865706201865708101865738151865738820.161000.000010.00220includedHepG2DDX59
    SESNX5ENSG00000089006.12chr20-1794901717949100179375761793768117949342179496230.071000.000260.03161includedHepG2DDX59
    SEHGSENSG00000185359.8chr17+7966827379668452796680387966816179668537796691490.117000.000370.04057includedHepG2DDX59
    SEARGLU1ENSG00000134884.9chr13-1072098561072099641072093951072094791072117791072120050.056000.000130.01857includedHepG2DDX59
    SETFAMENSG00000108064.6chr10+6015052460150620601484296014857960154117601541740.196000.000000.00000includedHepG2DDX59
    SEUBA1ENSG00000130985.12chrX+4705792547058027470532354705342347058201470583180.057000.000770.07018includedHepG2DDX59
    SEAKAP8LENSG00000011243.13chr19-1550944015509577155085241550866615510112155102210.063000.000780.07074includedHepG2DDX59
    SETXNL4AENSG00000141759.10chr18-7773759777737701777328747773385677748239777485930.091000.000000.00000includedHepG2DDX59
    SEPIN1ENSG00000127445.9chr19+9947333994755199459989946078994911199493240.084000.000110.01690includedHepG2DDX59
    SEVAPAENSG00000101558.9chr18+9944920994505599369829937063995039199505650.168000.000000.00000includedHepG2DDX59
    SEASNSENSG00000070669.12chr7-9750103097501308974990899749912597501662975018540.597000.000850.07623includedHepG2DDX59





    1 RBPs can affect the splicing of DDX59 :

    Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
    SEDDX59ENSG00000118197.9chr1-200617566200617695200613166200613645200618201200618354-0.327000.000070.00137excludedHepG2U2AF2

    *: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
    **: "-log(0)" was displayed as "99999.99999".





    No autoregularoty alternative splicing events between protein DDX59 and its RNA.