TOP1MT

General Information

Gene Name       : TOP1MT
Gene ID             : ENSG00000184428.12
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: TOP1MT)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878TOP1MTENSG00000184428.126.765.896.32ENCSR000AEF
HepG2TOP1MTENSG00000184428.1231.0525.4128.23ENCSR985KAT
K562TOP1MTENSG00000184428.1239.1743.4041.28ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for TOP1MT is not avaliable on ENCORE database.



Proteins bound to RNA
  • TOP1MT RNA is bound by 21 proteins.  







eCLIP assay for TOP1MT is not avaliable on ENCORE database.





21 proteins are bound to TOP1MT RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr8144411536144411638-3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal3.958703.02060K562LIN28B
chr8144407560144407628-3'-UTR,CDS,intron-Distal,intron-Proximal3.085184.96117K562YBX3
chr8144408454144408515-3'-UTR,CDS,intron-Distal,intron-Proximal3.239304.51003HepG2PPIG
chr8144408454144408514-3'-UTR,CDS,intron-Distal,intron-Proximal3.314188.76551K562ZNF622
chr8144406745144406799-3'-UTR,CDS,intron-Distal4.152284.45558HepG2GRWD1
chr8144406169144406259-3'-UTR,CDS,intron-Distal,intron-Proximal3.089067.93618K562UCHL5
chr8144398166144398265-3'-UTR,CDS,intron-Distal,intron-Proximal3.200497.42660K562PABPC4
chr8144400238144400256-3'-UTR,CDS,intron-Distal3.836053.25175K562YBX3
chr8144406575144406671-3'-UTR,CDS,intron-Distal,intron-Proximal4.683716.01989HepG2PRPF8
chr8144408395144408475-3'-UTR,CDS,intron-Distal,intron-Proximal3.112166.42293K562PUM1
chr8144413459144413565-3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal4.612937.08280K562SF3B4
chr8144406168144406217-3'-UTR,CDS,intron-Distal,intron-Proximal3.938378.94439K562LIN28B
chr8144403480144403551-3'-UTR,CDS,intron-Distal3.080313.40321HepG2GRWD1
chr8144408453144408517-3'-UTR,CDS,intron-Distal,intron-Proximal4.246413.31827HepG2GRWD1
chr8144407588144407705-3'-UTR,CDS,intron-Distal,intron-Proximal3.946776.80284K562DDX24
chr8144407622144407703-3'-UTR,CDS,intron-Distal,intron-Proximal4.6255510.38007K562UCHL5
chr8144408418144408459-3'-UTR,CDS,intron-Distal,intron-Proximal3.138537.53908K562GRWD1
chr8144406652144406695-3'-UTR,CDS,intron-Distal,intron-Proximal3.307513.44826K562METAP2
chr8144407550144407683-3'-UTR,CDS,intron-Distal,intron-Proximal3.124963.94537K562MTPAP
chr8144413425144413493-3'-UTR,5'-UTR,CDS,intron-Distal3.937066.12731K562UCHL5
chr8144407515144407635-3'-UTR,CDS,intron-Distal,intron-Proximal3.862527.03378HepG2GRWD1
chr8144407676144407704-3'-UTR,CDS,intron-Distal,intron-Proximal3.965413.45225K562GRWD1
chr8144407564144407651-3'-UTR,CDS,intron-Distal,intron-Proximal4.650845.23259HepG2BCLAF1
chr8144398189144398295-3'-UTR,CDS,intron-Distal,intron-Proximal3.066674.47839K562METAP2
chr8144407557144407658-3'-UTR,CDS,intron-Distal,intron-Proximal3.101549.17031K562ZNF622
chr8144408374144408443-3'-UTR,CDS,intron-Distal,intron-Proximal4.7671410.01989K562UCHL5
chr8144413418144413502-3'-UTR,5'-UTR,CDS,intron-Distal3.324264.51003HepG2PPIG
chr8144403380144403432-3'-UTR,CDS,intron-Distal4.467584.07072K562UCHL5
chr8144407551144407573-3'-UTR,CDS,intron-Distal,intron-Proximal3.032293.97676K562LIN28B
chr8144407514144407646-3'-UTR,CDS,intron-Distal,intron-Proximal3.251746.93667HepG2PPIG
chr8144403370144403405-3'-UTR,CDS,intron-Distal,intron-Proximal4.220615.13745K562YBX3
chr8144408445144408512-3'-UTR,CDS,intron-Distal,intron-Proximal4.7092211.10249K562UCHL5
chr8144408380144408453-3'-UTR,CDS,intron-Distal,intron-Proximal4.532476.01390HepG2GRWD1
chr8144407573144407629-3'-UTR,CDS,intron-Distal,intron-Proximal4.716286.10169K562LIN28B
chr8144416909144417032-5'-UTR,CDS,intron-Distal,intron-Proximal4.427548.96385K562DDX3X
chr8144416996144417034-5'-UTR,CDS,intron-Distal,intron-Proximal4.566135.24929K562ZNF622
chr8144392234144392349-CDS,intron-Distal,intron-Proximal5.550408.22604K562PUM1
chr8144397897144397986-CDS,intron-Distal,intron-Proximal4.5966910.38007K562UCHL5
chr8144397902144397986-CDS,intron-Distal,intron-Proximal4.083534.45558HepG2GRWD1
chr8144392308144392389-CDS,intron-Distal,intron-Proximal5.4633011.02908K562UCHL5
chr8144392288144392390-CDS,intron-Distal,intron-Proximal4.618707.51210K562ZNF800
chr8144392242144392308-CDS,intron-Distal3.608836.77066K562UCHL5
chr8144391676144391778-CDS,intron-Distal,intron-Proximal5.9986313.22655HepG2AQR
chr8144392270144392308-CDS,intron-Distal3.298075.94292K562ZNF622
chr8144411520144411574-CDS,intron-Distal,intron-Proximal4.857096.59793K562UCHL5
chr8144391687144391769-CDS,intron-Distal,intron-Proximal4.378236.81564HepG2PRPF8
chr8144392235144392383-CDS,intron-Distal,intron-Proximal3.662775.52031HepG2GRWD1
chr8144397911144397992-CDS,intron-Distal,intron-Proximal4.708479.59522K562PABPC4
chr8144392194144392254-CDS,intron-Distal,intron-Proximal3.683715.06115HepG2PRPF8
chr8144391624144391714-CDS,intron-Distal,intron-Proximal4.193247.37833K562PABPC4
chr8144403839144403918-intron-Distal4.790955.80675K562EIF4G2
chr8144392615144392715-intron-Distal,intron-Proximal4.026233.03671K562HNRNPM
chr8144397996144398086-intron-Distal,intron-Proximal3.331823.02792HepG2RBFOX2
chr8144403743144403807-intron-Distal5.508117.55693K562EIF4G2
chr8144405260144405336-intron-Distal5.6052915.80742K562EIF4G2
chr8144392387144392451-intron-Distal,intron-Proximal5.227755.90023K562SF3B4
chr8144405752144405792-intron-Distal4.525695.80675K562EIF4G2
chr8144405111144405152-intron-Distal5.442235.62492K562EIF4G2
chr8144406026144406062-intron-Distal4.691984.19739K562EIF4G2
chr8144395214144395271-intron-Distal3.014873.41836K562HNRNPM
chr8144391813144391884-intron-Distal5.7431310.83750HepG2RBFOX2
chr8144405200144405268-intron-Distal4.029663.34609K562TARDBP
chr8144405336144405407-intron-Distal5.4162713.86598K562EIF4G2
chr8144403588144403709-intron-Distal,intron-Proximal6.3808314.44525K562EIF4G2
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for TOP1MT is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for TOP1MT is not available on ENCORE database.

  • 89 RBPs can affect the levels of TOP1MT.  








The Knockdown/knockout RNA-Seq assay for TOP1MT is not available on ENCORE database.





89 RBPs can affect the gene expression of TOP1MT :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
TOP1MTENSG00000184428.8357.16310582.47770-0.705609.137108.16200HepG2ACO1
TOP1MTENSG00000184428.8596.39800807.02010-0.436302.445701.94230HepG2AKAP1
TOP1MTENSG00000184428.8640.56740931.30040-0.539903.753202.54820HepG2AKAP8
TOP1MTENSG00000184428.8544.79860378.803900.524202.370601.50520HepG2BCCIP
TOP1MTENSG00000184428.8505.72200758.31890-0.584505.189004.40130HepG2BOP1
TOP1MTENSG00000184428.8817.741501108.47140-0.438902.553601.62190HepG2CCAR1
TOP1MTENSG00000184428.8429.13150634.38330-0.563904.000703.07990HepG2CIRBP
TOP1MTENSG00000184428.8290.78530513.58260-0.820604.771103.76060HepG2CNOT7
TOP1MTENSG00000184428.8437.05890696.15590-0.671606.076705.09240HepG2CPSF6
TOP1MTENSG00000184428.8542.29840348.281800.638706.345704.80380HepG2YBX3
TOP1MTENSG00000184428.8646.97370538.701400.264102.048601.32190HepG2DDX19B
TOP1MTENSG00000184428.8453.51760773.00600-0.769306.989706.03690HepG2DDX3X
TOP1MTENSG00000184428.8214.54620372.46480-0.795805.092404.08250HepG2DDX55
TOP1MTENSG00000184428.8393.90830557.26930-0.500504.483703.65920HepG2DKC1
TOP1MTENSG00000184428.8464.97700341.968800.443203.211602.45930HepG2DNAJC21
TOP1MTENSG00000184428.8453.50730338.975000.419803.460102.74560HepG2DNAJC2
TOP1MTENSG00000184428.8399.13000638.34210-0.677505.212004.41330HepG2EIF2S1
TOP1MTENSG00000184428.8421.70300705.37720-0.742206.031505.09120HepG2EIF4A3
TOP1MTENSG00000184428.8896.95040643.552600.478905.827404.69150HepG2EIF4G1
TOP1MTENSG00000184428.8705.10060923.89030-0.389902.080901.40920HepG2FIP1L1
TOP1MTENSG00000184428.8396.81720660.28240-0.734606.058105.09060HepG2G3BP1
TOP1MTENSG00000184428.8467.54980599.49010-0.358602.633201.71990HepG2HNRNPA2B1
TOP1MTENSG00000184428.8457.65900753.04510-0.718505.227904.39240HepG2HNRNPLL
TOP1MTENSG00000184428.8504.52410671.12540-0.411702.391701.75870HepG2IGF2BP2
TOP1MTENSG00000184428.8566.68920389.678400.540206.084805.04000HepG2ILF2
TOP1MTENSG00000184428.8425.01620712.14470-0.744706.543305.54500HepG2MAGOH
TOP1MTENSG00000184428.8410.09060732.93980-0.837807.752106.71780HepG2NCBP2
TOP1MTENSG00000184428.8830.60650646.813500.360703.096402.29020HepG2NOL12
TOP1MTENSG00000184428.8561.51780377.599500.572404.062203.05790HepG2PARN
TOP1MTENSG00000184428.8449.59890692.73570-0.623707.597406.67050HepG2PCBP1
TOP1MTENSG00000184428.8574.74290340.257500.756209.111307.82190HepG2PPIL4
TOP1MTENSG00000184428.8394.37100704.92350-0.8379012.4799011.48320HepG2PTBP1
TOP1MTENSG00000184428.8890.24980655.458600.441606.035505.22880HepG2PUM1
TOP1MTENSG00000184428.8322.80500593.28900-0.8781013.3479012.17070HepG2PUS1
TOP1MTENSG00000184428.8524.86570763.36630-0.540405.232204.41390HepG2QKI
TOP1MTENSG00000184428.8342.55520692.83550-1.0162013.5121012.08760HepG2RBM25
TOP1MTENSG00000184428.8436.51880784.47970-0.8457012.5573011.55950HepG2NELFE
TOP1MTENSG00000184428.8803.03080339.729101.2410029.8071028.01550HepG2SAFB2
TOP1MTENSG00000184428.8575.54340880.45420-0.613303.999103.18210HepG2SF3A3
TOP1MTENSG00000184428.8499.52500733.84630-0.554904.919404.16670HepG2SF3B4
TOP1MTENSG00000184428.8579.87290396.173000.549506.093805.19790HepG2SMN1
TOP1MTENSG00000184428.8575.66170423.802400.441702.191301.34920HepG2SMNDC1
TOP1MTENSG00000184428.8529.65230829.32380-0.646903.748402.83380HepG2SNRNP70
TOP1MTENSG00000184428.8589.59920950.62790-0.6891011.2159010.39110HepG2SRFBP1
TOP1MTENSG00000184428.8414.72900766.00530-0.8852013.9475013.06050HepG2SRSF1
TOP1MTENSG00000184428.8335.84570825.37990-1.2973030.8267029.53690HepG2SSB
TOP1MTENSG00000184428.8898.14380693.332400.373303.903303.18720HepG2SUCLG1
TOP1MTENSG00000184428.8253.24570370.74890-0.549902.893902.20500HepG2SUPV3L1
TOP1MTENSG00000184428.8303.37400688.59470-1.1826019.8367018.53110HepG2TAF15
TOP1MTENSG00000184428.8647.84360992.35370-0.615202.500501.48270HepG2TBRG4
TOP1MTENSG00000184428.8491.80260374.005000.394903.060802.47470HepG2TRIM56
TOP1MTENSG00000184428.8331.48100218.989400.598003.039402.24580HepG2UCHL5
TOP1MTENSG00000184428.8634.00180780.82790-0.300502.696002.00510HepG2UPF1
TOP1MTENSG00000184428.8369.65650558.41380-0.595106.574605.61150HepG2ZC3H8
TOP1MTENSG00000184428.81003.02490858.761800.223902.112501.61640HepG2ZNF622
TOP1MTENSG00000184428.81165.601201547.41090-0.408803.967202.52300K562AARS
TOP1MTENSG00000184428.82623.116702022.246000.375206.917006.07800K562AGGF1
TOP1MTENSG00000184428.82534.763002104.256300.268402.289401.69350K562AKAP8L
TOP1MTENSG00000184428.81304.498501856.03760-0.508705.177904.41830K562AQR
TOP1MTENSG00000184428.82892.099902207.904700.389306.197704.76380K562ATP5C1
TOP1MTENSG00000184428.81136.47200903.138300.331403.113701.98570K562CSTF2
TOP1MTENSG00000184428.82429.602402062.882900.236002.754401.54490K562DDX21
TOP1MTENSG00000184428.83204.503602516.562300.348506.256905.33300K562DDX47
TOP1MTENSG00000184428.81442.24120970.402700.571603.585702.04190K562DHX30
TOP1MTENSG00000184428.83107.382102264.219700.456608.847407.11070K562DKC1
TOP1MTENSG00000184428.81546.707801832.33680-0.244502.436201.75380K562EIF2S2
TOP1MTENSG00000184428.8877.27450676.153300.375603.425602.54610K562EIF3G
TOP1MTENSG00000184428.8863.748801238.67510-0.520105.445204.29580K562EIF4A3
TOP1MTENSG00000184428.81105.020301470.45010-0.412203.159401.93860K562FKBP4
TOP1MTENSG00000184428.81152.425101426.52520-0.307802.206001.44000K562FMR1
TOP1MTENSG00000184428.8343.72500688.47880-1.002206.436505.25790K562G3BP2
TOP1MTENSG00000184428.82118.012801736.743700.286202.580101.54180K562HNRNPA1
TOP1MTENSG00000184428.8560.927301692.49450-1.5933046.0662043.75110K562HNRNPC
TOP1MTENSG00000184428.81208.20880915.701900.399803.488402.11150K562IGF2BP3
TOP1MTENSG00000184428.82808.978202233.079900.330903.566702.61700K562KIF1C
TOP1MTENSG00000184428.81211.300201639.86020-0.437004.499702.66630K562LARP7
TOP1MTENSG00000184428.81162.16470943.943300.299902.358801.51300K562MATR3
TOP1MTENSG00000184428.81846.116302855.25970-0.629109.147407.16320K562MSI2
TOP1MTENSG00000184428.81771.942002056.11830-0.214602.456801.69400K562MTPAP
TOP1MTENSG00000184428.8823.028201479.91840-0.8465010.435508.82550K562PCBP3
TOP1MTENSG00000184428.81224.517101652.63180-0.432604.275402.44530K562PHF6
TOP1MTENSG00000184428.8693.334601135.14510-0.711309.390307.95130K562POLR2G
TOP1MTENSG00000184428.82552.242802033.297500.327804.318703.59430K562RBM15
TOP1MTENSG00000184428.81132.676101385.00110-0.290202.416401.49420K562RCC2
TOP1MTENSG00000184428.8998.093601312.90220-0.395502.465501.51000K562SRFBP1
TOP1MTENSG00000184428.81852.332102309.45840-0.318205.709904.42690K562SRPK2
TOP1MTENSG00000184428.81157.18560851.058500.443203.899202.61580K562SRSF5
TOP1MTENSG00000184428.81152.20530911.797800.337502.313801.66380K562TARDBP
TOP1MTENSG00000184428.81220.34010879.557200.472304.834003.70680K562TIA1
TOP1MTENSG00000184428.81033.815801459.61150-0.497602.776401.83820K562TIAL1
TOP1MTENSG00000184428.81098.16010863.334600.347002.520401.48760K562TRA2A
TOP1MTENSG00000184428.82547.898503094.48000-0.280404.032602.49710K562TROVE2
TOP1MTENSG00000184428.81936.982202422.44330-0.322705.203204.25160K562UPF1
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for TOP1MT is not available on ENCORE database.





7 RBPs can affect the splicing of TOP1MT :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SETOP1MTENSG00000184428.8chr8-144392237144392387144391529144391713144397896144397991-0.069000.005740.08442excludedK562SRSF1
SETOP1MTENSG00000184428.8chr8-144416277144416455144413393144413509144416909144416965-0.201000.000580.01705excludedHepG2HNRNPK
SETOP1MTENSG00000184428.8chr8-1444162771444164551444133931444135091444169091444169650.168000.000040.00723includedHepG2DDX59
SETOP1MTENSG00000184428.8chr8-1444162771444164551444133931444135091444169091444169650.122000.002370.02900includedHepG2U2AF2
SETOP1MTENSG00000184428.8chr8-1444162771444164551444133931444135091444169091444169650.092000.000020.00036includedK562AQR
A3SSTOP1MTENSG00000184428.8chr8-1443922371443924261443922371443923871443978961443979910.058000.002030.01307longerK562AQR
MXETOP1MTENSG00000184428.8chr8-144392237144392387144397896144397991144391529144391713144398168144398296-0.141000.000140.009712includedK562LIN28B
MXETOP1MTENSG00000184428.8chr8-1443978961443979911443981681443982961443922371443923871443998921444000070.134000.004080.064991includedK562PRPF8
MXETOP1MTENSG00000184428.8chr8-1443978961443979911443980781443982961443922371443923871443998921444000070.130000.004960.074141includedK562PRPF8

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for TOP1MT is not avaliable on ENCORE database.