LARP7

General Information

Gene Name : LARP7
Gene ID : ENSG00000174720.15
Essential Gene : No

Functions

Other

Localization(RBPImage: LARP7)

Nuclei
Nucleoplasm
Nucleolus
Cytoplasm
Compartment/Organelle
Unknown Cyto Foci
Cytosolic
Nuclear release mitosis

Domains (AlphaFold: LARP7)

RRM

Antibody Validation

Bethyl Labs: A303-723A

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	LARP7	ENSG00000174720.15	69.84	57.75	63.80	ENCSR000AEF
HepG2	LARP7	ENSG00000174720.15	17.40	39.10	28.25	ENCSR985KAT
K562	LARP7	ENSG00000174720.15	44.71	51.69	48.20	ENCSR000AEO

Assays

4 Released experiments are available on ENCORE database.

Assay Type	Exp_Name	ENCODE ID	Target label	Biosample	Status	Linked Antibody	Controls	Method	Note
eCLIP	eCLIP: 243	ENCSR456KXI	LARP7	K562	Released	ENCAB568DRS	ENCSR863ZGZ
eCLIP	eCLIP: 298	ENCSR961OKA	LARP7	HepG2	Released	ENCAB568DRS	ENCSR095SIV
knockdown followed by RNA-seq	LARP7-BGKLV21-K562	ENCSR770OWW	LARP7	K562	Released		ENCSR572FFX	shRNA	KD% = 77.1,72.3
knockdown followed by RNA-seq	LARP7-BGHLV18-HepG2	ENCSR624FBY	LARP7	HepG2	Released		ENCSR674KEK	shRNA	KD% = 88.6,95.9

eCLIP

RBP	Exp_UID	Cell_Line	ENCODE_ACCESSION	Control_ENCODE_ACCESSION	ENCODE_Antibody_ID	Antibody	Lot_num	Status	Project
LARP7	243	K562	ENCSR456KXI	ENCSR863ZGZ	ENCAB568DRS	A303-723A	1	Released	ENCODE3
LARP7	298	HepG2	ENCSR961OKA	ENCSR095SIV	ENCAB568DRS	A303-723A	1	Released	ENCODE3

Antibody Validation

GeneName	Antibody_DCC_ID	Product_ID	Lot_ID	Phosphate	HepG2 Primary Validation	K562 Primary Validation	HepG2 Secondary Validation	K562 Secondary Validation
LARP7	ENCAB568DRS	A303-723A	1		Released, ENCODE3	Released, ENCODE3	BGHLV18-19, Released, ENCODE3	BGKLV21-25, Released, ENCODE3

KD RNA-Seq

GeneName	Cell_Line	Method	Exp_ID	Control_ID	Sample_reps	Control_reps	KD%	Status	Project	Note
LARP7	K562	shRNA	ENCSR770OWW	ENCSR572FFX	LARP7_BGKLV21_25_17571,LARP7_BGKLV21_26_17572	non-target_BGKLV21_1,non-target_BGKLV21_2	77.1,72.3	Released	ENCODE3
LARP7	HepG2	shRNA	ENCSR624FBY	ENCSR674KEK	LARP7_BGHLV18_19,LARP7_BGHLV18_20	NT_BGHLV18_1,NT_BGHLV18_2	88.6,95.9	Released	ENCODE3

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

LARP7: Click to RBP Image Database

Nuclei

Nucleoplasm

Nucleolus

Cytoplasm

Compartment/Organelle

Unknown Cyto Foci

Cytosolic

Nuclear release mitosis

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela
LARP7	Product_ID: A303-723A Lot_ID: 1 Source: Bethyl Labs Target Name: LARP7-human

RNA Targets

LARP7 protein binds to 300 RNA regions.

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Proteins bound to RNA

LARP7 RNA is bound by 7 proteins.

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LARP7 protein has 300 RNA targets:

Only display 100 entries as example. Please click "View All" button to see all 300 entries.

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RBP	Chr	Start	End	Strand	log2(fold change)	-log(p-value)	Cell Line	Matched Gene	Matched Area
LARP7	chr17	7480211	7480225	+	4.10508	400.00000	K562	SNORA67, EIF4A1, SENP3-EIF4A1	intron-Distal
LARP7	chr19	50001042	50001049	+	3.83168	400.00000	K562	RPS11	intron-Distal
LARP7	chr11	17097321	17097411	-	4.81825	400.00000	HepG2	RPS13	intron-Distal
LARP7	chr2	86363123	86363129	+	8.27029	400.00000	HepG2	PTCD3	intron-Distal
LARP7	chr3	186502597	186502618	+	4.74726	400.00000	HepG2	EIF4A2	intron-Distal
LARP7	chr11	62622806	62622831	-	3.36491	400.00000	HepG2	SNHG1	intron-Distal,intron-Proximal
LARP7	chr17	7480248	7480264	+	4.13273	400.00000	K562	SNORA67, SENP3-EIF4A1, EIF4A1	intron-Distal
LARP7	chr9	136217754	136217769	+	6.64093	400.00000	HepG2	RPL7A	intron-Distal,intron-Proximal
LARP7	chr13	99858154	99858180	+	7.91572	400.00000	K562	UBAC2	intron-Distal
LARP7	chr11	62622775	62622804	-	4.00283	400.00000	HepG2	SNHG1	intron-Distal,intron-Proximal

Showing 1 to 10 of 100 entries

7 proteins are bound to LARP7 RNA:

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Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr4	113568365	113568509	+	3'-UTR,CDS,intron-Distal	4.93844	12.89578	HepG2	BCLAF1
chr4	113565874	113566013	+	CDS,intron-Distal,intron-Proximal	4.46330	12.69640	K562	UCHL5
chr4	113568369	113568488	+	3'-UTR,CDS,intron-Distal	4.80532	11.98007	K562	ZNF622
chr4	113565869	113566011	+	CDS,intron-Distal,intron-Proximal	4.89136	11.63999	K562	ZNF622
chr4	113568426	113568505	+	3'-UTR,CDS,intron-Distal	5.48027	11.02908	K562	UCHL5
chr4	113578599	113578680	+	3'-UTR	5.93072	9.17142	K562	PUM2
chr4	113565823	113565874	+	3'-UTR,5'-UTR,CDS,intron-Proximal	3.80910	8.06634	K562	UCHL5
chr4	113570690	113570751	+	3'-UTR,CDS,intron-Proximal	5.18358	8.06523	K562	UCHL5
chr4	113568561	113568638	+	3'-UTR,CDS,intron-Distal	5.09980	7.60619	K562	UCHL5
chr4	113565822	113565869	+	3'-UTR,5'-UTR,CDS,intron-Proximal	3.64614	7.05173	K562	ZNF622
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

Showing 1 to 10 of 20 entries

No autoregularoty interactions between protein LARP7 and its RNA.

Diffrential Expression

3,154 differentially expressed genes after Knockdown/Knockout LARP7 protein.

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55 RBPs can affect the levels of LARP7.

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3,154 differentially expressed genes after Knockdown/Knockout LARP7 protein :

Only display 100 entries as example. Please click "View All" button to see all 3,154 entries.

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Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
NR1H4	ENSG00000012504.9	229.33670	739.86850	-1.68980	25.32720	22.35990	HepG2	LARP7
KITLG	ENSG00000049130.9	564.82030	220.63700	1.35600	18.99020	16.33260	HepG2	LARP7
TIMP2	ENSG00000035862.8	2226.22380	1162.49610	0.93730	17.90290	15.30860	HepG2	LARP7
TMSB10	ENSG00000034510.4	8863.96830	4730.78910	0.90580	16.64520	14.14750	HepG2	LARP7
ITIH1	ENSG00000055957.6	95.74770	302.08200	-1.65760	16.38820	13.91510	HepG2	LARP7
ADIPOR2	ENSG00000006831.9	1471.67660	2866.05870	-0.96160	15.46530	13.02430	HepG2	LARP7
CYP24A1	ENSG00000019186.5	1450.80480	407.79800	1.83080	13.99040	11.63370	HepG2	LARP7
ITGA3	ENSG00000005884.13	215.11300	68.78100	1.64490	11.87150	9.67060	HepG2	LARP7
MVP	ENSG00000013364.14	1284.59120	650.70100	0.98110	11.36540	9.22030	HepG2	LARP7
DCBLD2	ENSG00000057019.11	6398.83220	3078.83650	1.05530	9.85900	7.84910	HepG2	LARP7
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 100 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

55 RBPs can affect the gene expression of LARP7 :

Show entries

Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
LARP7	ENSG00000174720.11	115.45320	890.57250	-2.94740	81.20660	76.84680	K562	LARP7
LARP7	ENSG00000174720.11	174.01460	630.12010	-1.85640	32.11880	28.75350	HepG2	LARP7
LARP7	ENSG00000174720.11	1377.25760	706.68840	0.96260	14.68780	12.94390	K562	PRPF8
LARP7	ENSG00000174720.11	676.68370	1161.36580	-0.77930	11.20360	9.79320	K562	SRSF1
LARP7	ENSG00000174720.11	416.21050	820.27380	-0.97880	10.88620	9.75810	HepG2	EIF2S1
LARP7	ENSG00000174720.11	1570.79850	977.46830	0.68430	9.74670	8.19710	K562	SYNCRIP
LARP7	ENSG00000174720.11	828.97780	1902.25730	-1.19830	8.55790	6.49200	K562	PABPN1
LARP7	ENSG00000174720.11	1650.96910	1142.12820	0.53150	7.62230	6.28330	K562	U2AF2
LARP7	ENSG00000174720.11	738.45360	1165.88740	-0.65880	7.29200	6.19120	HepG2	TARDBP
LARP7	ENSG00000174720.11	561.05760	941.70460	-0.74710	6.96630	5.98250	HepG2	NCBP2
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 62 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

287 alternative splicing events after Knockdown/Knockout LARP7 protein :

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Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	FDR	is_included	Cell Line	Affected by RBP
SE	ZC3H4	ENSG00000130749.5	chr19	-	47614151	47614213	47597645	47597865	47615404	47615504	0.45500	0.00761	included	HepG2	LARP7
SE	APOC1	ENSG00000130208.5	chr19	+	45417928	45417990	45417503	45417746	45418128	45418206	0.11700	0.00000	included	HepG2	LARP7
SE	EIF4H	ENSG00000106682.10	chr7	+	73604576	73604636	73604151	73604248	73609070	73609208	0.12900	0.00038	included	HepG2	LARP7
SE	SEC31A	ENSG00000138674.12	chr4	-	83782783	83782861	83778841	83778917	83784470	83784545	0.17600	0.00111	included	HepG2	LARP7
SE	FIP1L1	ENSG00000145216.11	chr4	+	54245239	54245284	54244005	54244090	54245391	54245431	0.38800	0.00360	included	HepG2	LARP7
SE	CRYZ	ENSG00000116791.9	chr1	-	75172786	75172888	75172582	75172678	75175781	75175931	0.19300	0.00000	included	HepG2	LARP7
SE	CLSTN1	ENSG00000171603.12	chr1	-	9797555	9797612	9795942	9796100	9801151	9801314	0.18100	0.00001	included	HepG2	LARP7
SE	COL18A1	ENSG00000182871.10	chr21	+	46889762	46889900	46888155	46888700	46893808	46893895	-0.16300	0.00155	excluded	HepG2	LARP7
SE	BPIFB2	ENSG00000078898.6	chr20	+	31596005	31596184	31595405	31595566	31596346	31596489	-0.27100	0.00415	excluded	HepG2	LARP7
SE	CTSB	ENSG00000164733.16	chr8	-	11721884	11721972	11710837	11710988	11725509	11725549	-0.10000	0.00232	excluded	HepG2	LARP7

Showing 1 to 10 of 100 entries

10 RBPs can affect the splicing of LARP7 :

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Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	p-value	FDR	is_included	Cell Line	Affected by RBP
SE	LARP7	ENSG00000174720.11	chr4	+	113565580	113565644	113558281	113558395	113565823	113565944	0.13900	0.00000	0.00000	included	HepG2	U2AF1
SE	LARP7	ENSG00000174720.11	chr4	+	113566706	113566818	113565823	113566027	113567506	113567607	0.11500	0.00000	0.00015	included	HepG2	HNRNPK
SE	LARP7	ENSG00000174720.11	chr4	+	113565580	113565644	113558281	113558395	113565823	113566027	0.08000	0.00000	0.00000	included	HepG2	U2AF2
SE	LARP7	ENSG00000174720.11	chr4	+	113570690	113570842	113568851	113568990	113571616	113571760	-0.07000	0.00000	0.00005	excluded	K562	AQR
SE	LARP7	ENSG00000174720.11	chr4	+	113566706	113566818	113565823	113566027	113567506	113567607	0.16600	0.00000	0.00063	included	K562	HNRNPK
A3SS	LARP7	ENSG00000174720.11	chr4	+	113570659	113570877	113570690	113570877	113568851	113568990	0.06500	0.00000	0.00005	longer	K562	AQR
SE	LARP7	ENSG00000174720.11	chr4	+	113566706	113566818	113565823	113566027	113567506	113567607	0.19900	0.00015	0.00393	included	K562	HNRNPC
A5SS	LARP7	ENSG00000174720.11	chr4	+	113565823	113566027	113565823	113565924	113567506	113567607	-0.17000	0.00025	0.09036	shorter	K562	EIF3G
A5SS	LARP7	ENSG00000174720.11	chr4	+	113565823	113566027	113565823	113565924	113567506	113567607	0.16500	0.00027	0.02706	longer	K562	RBM15
SE	LARP7	ENSG00000174720.11	chr4	+	113566706	113566818	113565823	113566027	113567506	113567607	-0.07000	0.00070	0.02934	excluded	K562	FXR1

Showing 1 to 10 of 13 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

LARP7

General Information

Functions

Localization(RBPImage: LARP7)

Domains (AlphaFold: LARP7)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

LARP7 protein has 300 RNA targets:

7 proteins are bound to LARP7 RNA:

No autoregularoty interactions between protein LARP7 and its RNA.

Diffrential Expression

3,154 differentially expressed genes after Knockdown/Knockout LARP7 protein :

55 RBPs can affect the gene expression of LARP7 :

287 alternative splicing events after Knockdown/Knockout LARP7 protein :

10 RBPs can affect the splicing of LARP7 :

No autoregularoty alternative splicing events between protein LARP7 and its RNA.