USP28

General Information

Gene Name       : USP28
Gene ID             : ENSG00000048028.11
Essential Gene : No

Functions

Localization

Domains (AlphaFold: USP28)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878USP28ENSG00000048028.1125.7024.6825.19ENCSR000AEF
HepG2USP28ENSG00000048028.1120.4034.9827.69ENCSR985KAT
K562USP28ENSG00000048028.1121.0428.7124.88ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for USP28 is not avaliable on ENCORE database.



Proteins bound to RNA
  • USP28 RNA is bound by 5 proteins.  







eCLIP assay for USP28 is not avaliable on ENCORE database.





5 proteins are bound to USP28 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr11113675394113675468-3'-UTR,CDS,intron-Distal,intron-Proximal4.996785.70640HepG2BCLAF1
chr11113674522113674600-3'-UTR,CDS,intron-Distal,intron-Proximal3.593116.39464HepG2BCLAF1
chr11113688467113688551-3'-UTR,CDS,intron-Distal,intron-Proximal3.274864.74886HepG2BCLAF1
chr11113675394113675452-3'-UTR,CDS,intron-Distal,intron-Proximal4.522404.77252K562ZNF622
chr11113675392113675475-3'-UTR,CDS,intron-Distal,intron-Proximal4.309434.67744K562BUD13
chr11113703772113703890-intron-Distal5.075103.56466K562LSM11
chr11113703901113704010-intron-Distal3.584134.65797K562TARDBP
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for USP28 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for USP28 is not available on ENCORE database.

  • 101 RBPs can affect the levels of USP28.  








The Knockdown/knockout RNA-Seq assay for USP28 is not available on ENCORE database.





101 RBPs can affect the gene expression of USP28 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
USP28ENSG00000048028.71417.31800988.832200.519308.692907.58870HepG2AUH
USP28ENSG00000048028.7444.44240697.51340-0.650204.074802.94020HepG2BCCIP
USP28ENSG00000048028.7433.32820606.13000-0.484202.517501.65980HepG2BCLAF1
USP28ENSG00000048028.7501.33880690.84800-0.462602.261601.71500HepG2BOP1
USP28ENSG00000048028.7723.41020924.88380-0.354502.950002.15600HepG2CALR
USP28ENSG00000048028.7485.40380892.01690-0.8779018.8493017.45250HepG2CKAP4
USP28ENSG00000048028.7465.02960634.26090-0.447801.899201.31780HepG2CPSF6
USP28ENSG00000048028.7657.19290821.95530-0.322702.610001.62320HepG2YBX3
USP28ENSG00000048028.7582.866001166.14970-1.0005028.9608027.05240HepG2DAZAP1
USP28ENSG00000048028.7334.79550519.59920-0.634103.428001.87210HepG2DDX28
USP28ENSG00000048028.7545.37850768.41610-0.494603.318702.64140HepG2DDX3X
USP28ENSG00000048028.7460.46140685.77700-0.574703.320402.48370HepG2DDX55
USP28ENSG00000048028.7565.63620847.85870-0.583905.224503.87260HepG2DDX5
USP28ENSG00000048028.7939.80570660.121800.509503.431202.75130HepG2DDX6
USP28ENSG00000048028.7621.22420853.56320-0.458405.055804.19000HepG2DKC1
USP28ENSG00000048028.7484.64000807.10250-0.7358010.606809.30400HepG2DNAJC21
USP28ENSG00000048028.7424.09550799.96980-0.9156019.1756017.60830HepG2DNAJC2
USP28ENSG00000048028.7496.63990723.45280-0.542703.490902.46170HepG2EEF2
USP28ENSG00000048028.7402.17160603.18990-0.584803.875902.55780HepG2EFTUD2
USP28ENSG00000048028.7353.36340587.33300-0.733003.821502.76940HepG2EIF3D
USP28ENSG00000048028.7310.52660701.24030-1.1752013.0763011.71200HepG2EIF4A3
USP28ENSG00000048028.7920.587201150.39540-0.321503.571002.63970HepG2EIF4G1
USP28ENSG00000048028.7803.630001102.02000-0.455503.908502.94970HepG2EIF4G2
USP28ENSG00000048028.7535.88360871.84410-0.702208.454907.00840HepG2EWSR1
USP28ENSG00000048028.7696.61560437.858700.669806.664605.47480HepG2FUBP3
USP28ENSG00000048028.7535.94720719.05210-0.424002.023301.47080HepG2GPKOW
USP28ENSG00000048028.7592.96490869.53200-0.552303.025701.37320HepG2GTF2F1
USP28ENSG00000048028.7673.43230851.78550-0.339003.328902.26330HepG2HDGF
USP28ENSG00000048028.7495.12980814.83470-0.718707.660206.66670HepG2HNRNPA1
USP28ENSG00000048028.7851.200001071.67860-0.332303.447002.42010HepG2HNRNPA2B1
USP28ENSG00000048028.7481.24790906.35110-0.9133011.8156010.47000HepG2HNRNPC
USP28ENSG00000048028.7888.506101062.30230-0.257702.716102.04840HepG2HNRNPL
USP28ENSG00000048028.7463.33480686.19850-0.566602.555201.94600HepG2HNRNPLL
USP28ENSG00000048028.7580.50470900.35900-0.633209.916508.82610HepG2HNRNPU
USP28ENSG00000048028.7760.25390919.68720-0.274702.646401.92780HepG2ILF2
USP28ENSG00000048028.7680.38720815.57550-0.261502.354001.41290HepG2KIF1C
USP28ENSG00000048028.7786.410301271.77940-0.693505.826504.61170HepG2LARP4
USP28ENSG00000048028.7561.22620758.17830-0.434002.905201.74330HepG2LARP7
USP28ENSG00000048028.7509.07220796.29550-0.645405.652603.93050HepG2LIN28B
USP28ENSG00000048028.7380.67300614.73280-0.691403.511002.33030HepG2METAP2
USP28ENSG00000048028.7613.44140781.43500-0.349202.582501.79950HepG2MSI2
USP28ENSG00000048028.7481.35120728.53460-0.597904.362403.57480HepG2NCBP2
USP28ENSG00000048028.7488.27660685.58080-0.489603.389701.82700HepG2NIP7
USP28ENSG00000048028.7966.178101156.34650-0.259202.163201.48710HepG2NOL12
USP28ENSG00000048028.7233.95240439.14450-0.908505.171503.03720HepG2PA2G4
USP28ENSG00000048028.7399.62860648.77540-0.699105.647804.62870HepG2PABPC4
USP28ENSG00000048028.7742.18630891.20360-0.264002.177201.41790HepG2PARN
USP28ENSG00000048028.7469.61780683.03830-0.540505.930105.09530HepG2PCBP1
USP28ENSG00000048028.7578.09450873.66430-0.595803.602802.42490HepG2PCBP2
USP28ENSG00000048028.7476.69820727.74070-0.610303.690301.75590HepG2PHF6
USP28ENSG00000048028.7324.90930485.70060-0.580003.557502.16040HepG2PKM
USP28ENSG00000048028.7590.75270803.04860-0.442904.490303.57220HepG2PPIL4
USP28ENSG00000048028.7317.57830529.15020-0.736605.059304.00040HepG2PRPF8
USP28ENSG00000048028.7440.76270695.03960-0.657107.921607.09320HepG2PTBP1
USP28ENSG00000048028.7543.704801103.80720-1.0216017.3869016.06470HepG2PUF60
USP28ENSG00000048028.7669.349401171.70880-0.8078020.8548019.53240HepG2PUM1
USP28ENSG00000048028.7542.743201170.87240-1.1092023.3927021.55830HepG2PUM2
USP28ENSG00000048028.7341.50240908.72360-1.4119040.6103038.80470HepG2PUS1
USP28ENSG00000048028.7480.45450752.69690-0.647707.160306.22400HepG2QKI
USP28ENSG00000048028.7504.35710914.21320-0.858109.355207.51630HepG2RBM27
USP28ENSG00000048028.7481.14240742.37890-0.625704.493303.13940HepG2RCC2
USP28ENSG00000048028.7506.58650784.75870-0.631406.286305.31520HepG2RPLP0
USP28ENSG00000048028.7258.79830571.45370-1.1428010.192209.10130HepG2RPS19
USP28ENSG00000048028.7461.77630843.19380-0.868709.302807.90720HepG2RPS2
USP28ENSG00000048028.7454.61260725.38020-0.674104.542903.51970HepG2RPS3A
USP28ENSG00000048028.7595.40910860.66730-0.531603.846602.56390HepG2RPS5
USP28ENSG00000048028.7561.88870801.81060-0.513006.620405.68780HepG2SAFB2
USP28ENSG00000048028.7335.51340573.61750-0.773705.288403.99910HepG2SERBP1
USP28ENSG00000048028.7836.680701058.31470-0.339004.168003.33160HepG2SLBP
USP28ENSG00000048028.7630.99140935.04850-0.567409.466708.39210HepG2SMN1
USP28ENSG00000048028.71444.529501071.751300.430506.790006.10190HepG2SRFBP1
USP28ENSG00000048028.7645.618601089.81130-0.7553014.5932013.31740HepG2SRSF5
USP28ENSG00000048028.7502.93630715.67920-0.508905.941504.98440HepG2SRSF7
USP28ENSG00000048028.7771.99280930.54930-0.269502.297701.82100HepG2SSB
USP28ENSG00000048028.7969.366501239.44780-0.354604.817704.03750HepG2SUCLG1
USP28ENSG00000048028.7550.45150782.83380-0.508102.933301.56610HepG2SUGP2
USP28ENSG00000048028.7383.24330682.71770-0.833006.358605.39580HepG2SUPV3L1
USP28ENSG00000048028.7942.41300678.923800.473005.428504.68800HepG2TAF15
USP28ENSG00000048028.7771.64880623.789800.306802.186901.44180HepG2TIA1
USP28ENSG00000048028.7394.18060874.87410-1.1502021.4711020.32220HepG2TIAL1
USP28ENSG00000048028.7655.85910882.68720-0.428504.973204.26150HepG2TRIM56
USP28ENSG00000048028.7275.34260466.73710-0.761405.158603.04390HepG2TROVE2
USP28ENSG00000048028.7685.052101078.32170-0.654508.349506.69750HepG2TUFM
USP28ENSG00000048028.7603.42040826.02340-0.453003.479402.77990HepG2U2AF1
USP28ENSG00000048028.7750.346401141.35300-0.605104.971903.82720HepG2UBE2L3
USP28ENSG00000048028.7609.73200860.05540-0.496306.424905.43370HepG2UPF1
USP28ENSG00000048028.7421.66060625.25870-0.568402.689601.69950HepG2UPF2
USP28ENSG00000048028.7654.18840830.34920-0.344003.186502.55210HepG2UTP3
USP28ENSG00000048028.7581.32250828.99930-0.512002.746101.48730HepG2XRCC5
USP28ENSG00000048028.7415.71050672.05960-0.693005.008004.04170HepG2XRN2
USP28ENSG00000048028.7725.31070945.89580-0.383104.909204.23330HepG2ZNF622
USP28ENSG00000048028.7596.30590842.26200-0.498202.940501.59880HepG2ZRANB2
USP28ENSG00000048028.7967.51060693.073300.481203.725002.71120K562BOP1
USP28ENSG00000048028.7900.66760736.929300.289401.978001.30630K562CPSF6
USP28ENSG00000048028.71517.118401290.179000.233702.238801.46160K562DKC1
USP28ENSG00000048028.7592.19850791.85040-0.419103.134202.50460K562HNRNPC
USP28ENSG00000048028.7765.020001050.34220-0.457304.484403.28350K562MATR3
USP28ENSG00000048028.71791.660901425.453600.329803.201602.21190K562MBNL1
USP28ENSG00000048028.7489.68130686.20090-0.486803.211501.78880K562NONO
USP28ENSG00000048028.7575.56180740.64970-0.363802.720101.92660K562POLR2G
USP28ENSG00000048028.7492.63590677.65300-0.460002.978802.20120K562PRPF8
USP28ENSG00000048028.7640.628301022.46750-0.674509.080007.92310K562PTBP1
USP28ENSG00000048028.71286.295301919.28860-0.5773010.199808.33430K562PUM2
USP28ENSG00000048028.7926.884401189.03680-0.359302.275801.77370K562PUS1
USP28ENSG00000048028.7763.80300980.62070-0.360502.645001.82430K562RBM22
USP28ENSG00000048028.7686.989901031.90050-0.586905.594603.96220K562NELFE
USP28ENSG00000048028.7820.492701002.31870-0.288802.035201.41840K562SRSF1
USP28ENSG00000048028.7594.79220758.54070-0.350802.347501.38970K562SRSF4
USP28ENSG00000048028.7533.376401014.49890-0.9275012.5103010.81460K562TARDBP
USP28ENSG00000048028.7780.43600978.57590-0.326402.524701.74750K562TIA1
USP28ENSG00000048028.7505.96260707.11540-0.482903.382402.00300K562XRN2
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for USP28 is not available on ENCORE database.





11 RBPs can affect the splicing of USP28 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEUSP28ENSG00000048028.7chr11-1137059281137060491137049701137050571137113191137114790.084000.000670.09103includedK562MATR3
SEUSP28ENSG00000048028.7chr11-113704970113705057113704141113704279113711319113711479-0.376000.000000.00011excludedHepG2U2AF1
SEUSP28ENSG00000048028.7chr11-113672204113672400113668597113670137113673879113674003-0.105000.003370.05566excludedHepG2U2AF1
SEUSP28ENSG00000048028.7chr11-1137452381137455221137249791137250571137461661137462580.466000.000420.08558includedK562WDR43
SEUSP28ENSG00000048028.7chr11-1136786721136788581136755891136757681136790191136791590.161000.000410.01289includedHepG2HNRNPK
SEUSP28ENSG00000048028.7chr11-1136995651136996421136979541136980821136999181137000670.205000.000040.00196includedHepG2HNRNPK
SEUSP28ENSG00000048028.7chr11-113704970113705057113704141113704279113711319113711479-0.210000.003620.04092excludedHepG2U2AF2
SEUSP28ENSG00000048028.7chr11-1136995651136996421136979541136980821136999181137001660.083000.000180.00282includedK562AQR
SEUSP28ENSG00000048028.7chr11-113724979113725057113712384113712490113746166113746256-0.399000.008260.06973excludedK562AQR
SEUSP28ENSG00000048028.7chr11-1137452381137455221137249791137250571137461661137462580.570000.003060.09010includedK562FXR1
SEUSP28ENSG00000048028.7chr11-113701588113701665113699918113700067113704141113704274-0.196000.004470.05706excludedK562PUS1
SEUSP28ENSG00000048028.7chr11-113704970113705057113704141113704279113711319113711479-0.232000.000000.00009excludedK562PUS1
SEUSP28ENSG00000048028.7chr11-113724979113725057113712384113712490113746166113746288-0.445000.004980.06202excludedK562PUS1
SEUSP28ENSG00000048028.7chr11-1136772101136773061136755891136757681136790191136791590.325000.000010.00072includedHepG2PTBP1
SEUSP28ENSG00000048028.7chr11-113704970113705057113704141113704279113711319113711479-0.293000.001370.02906excludedK562U2AF1
SEUSP28ENSG00000048028.7chr11-1136995651136996421136979541136980821136999181137000840.062000.000280.04995includedK562EIF4G2
SEUSP28ENSG00000048028.7chr11-113704970113705057113704141113704279113711319113711479-0.288000.000000.00009excludedK562U2AF2
SEUSP28ENSG00000048028.7chr11-1137452381137456011137249791137250571137461661137462550.401000.001150.03028includedK562RBM15
SEUSP28ENSG00000048028.7chr11-1136786721136788581136755891136757681136790191136791590.091000.000930.04231includedK562HNRNPK
SEUSP28ENSG00000048028.7chr11-1137059281137060491137049701137050571137113191137114790.116000.000050.00387includedK562PTBP1
SEUSP28ENSG00000048028.7chr11-1136772101136773061136755891136757681136790191136791590.192000.000000.00039includedK562PTBP1
A3SSUSP28ENSG00000048028.7chr11-1136883791136885961136883791136885591136943261136944220.160000.000810.00575longerK562AQR

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for USP28 is not avaliable on ENCORE database.