GTF2F1

General Information

Gene Name : GTF2F1
Gene ID : ENSG00000125651.13
Essential Gene : No

Functions

Novel RBP

Localization

Not Available

Domains (AlphaFold: GTF2F1)

No checked domain (RRM, ZNF, KH, Helicase, Nuclease, dRBM or PUM_HD)

Antibody Validation

View validation images for all GTF2F1 antibodies

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	GTF2F1	ENSG00000125651.13	18.68	36.12	27.40	ENCSR000AEF
HepG2	GTF2F1	ENSG00000125651.13	58.58	31.15	44.86	ENCSR985KAT
K562	GTF2F1	ENSG00000125651.13	62.08	46.00	54.04	ENCSR000AEO

Assays

4 Released experiments are available on ENCORE database.

Assay Type	Exp_Name	ENCODE ID	Target label	Biosample	Status	Linked Antibody	Controls	Method	Note
eCLIP	eCLIP: 342	ENCSR736AAG	GTF2F1	K562	Released	ENCAB108WPN	ENCSR157BRV
eCLIP	eCLIP: 384	ENCSR265ZIS	GTF2F1	HepG2	Released	ENCAB108WPN	ENCSR451HMR
knockdown followed by RNA-seq	GTF2F1-BGKLV13-K562	ENCSR188IPO	GTF2F1	K562	Released		ENCSR815CVQ	shRNA	KD% = 86.0,88.6
knockdown followed by RNA-seq	GTF2F1-BGHLV14-HepG2	ENCSR295XKC	GTF2F1	HepG2	Released		ENCSR491FOC	shRNA	KD% = 90.3,85.4

eCLIP

RBP	Exp_UID	Cell_Line	ENCODE_ACCESSION	Control_ENCODE_ACCESSION	ENCODE_Antibody_ID	Antibody	Lot_num	Status	Project
GTF2F1	342	K562	ENCSR736AAG	ENCSR157BRV	ENCAB108WPN	GTX114455	40723	Released	ENCODE3
GTF2F1	384	HepG2	ENCSR265ZIS	ENCSR451HMR	ENCAB108WPN	GTX114455	40723	Released	ENCODE3

Antibody Validation

GeneName	Antibody_DCC_ID	Product_ID	Lot_ID	Phosphate	HepG2 Primary Validation	K562 Primary Validation	HepG2 Secondary Validation	K562 Secondary Validation
GTF2F1	ENCAB108WPN	GTX114455	40723		Released, ENCODE3	Released, ENCODE3	BGHLV14-23, Released, ENCODE3	BGKLV13_39, Released, ENCODE3
GTF2F1	ENCAB576INM	PA5-30050	TL2692997A			Released, ENCODE4	BGHLV14-23, Released, ENCODE4

KD RNA-Seq

GeneName	Cell_Line	Method	Exp_ID	Control_ID	Sample_reps	Control_reps	KD%	Status	Project	Note
GTF2F1	K562	shRNA	ENCSR188IPO	ENCSR815CVQ	GTF2F1_BGKLV13_39,GTF2F1_BGKLV13_40	NT_BGKLV13_1,NT_BGKLV13_2	86.0,88.6	Released	ENCODE3
GTF2F1	HepG2	shRNA	ENCSR295XKC	ENCSR491FOC	GTF2F1_BGHLV14-23,GTF2F1_BGHLV14-24	NT_BGHLV14-1,NT_BGHLV14-2	90.3,85.4	Released	ENCODE3

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

No Localization Information available

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela
GTF2F1	Product_ID: GTX114455 Lot_ID: 40723 Source: GeneTex Target Name: GTF2F1-human
GTF2F1	Product_ID: PA5-30050 Lot_ID: TL2692997A Source: Thermo Fisher Target Name: GTF2F1-human

RNA Targets

GTF2F1 protein binds to 9,437 RNA regions.

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Proteins bound to RNA

GTF2F1 RNA is bound by 22 proteins.

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GTF2F1 protein has 9,437 RNA targets:

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RBP	Chr	Start	End	Strand	log2(fold change)	-log(p-value)	Cell Line	Matched Gene	Matched Area
GTF2F1	chr11	2153316	2153323	-	5.34047	400.00000	HepG2	IGF2	3'-UTR,intron-Distal
GTF2F1	chr11	2152752	2152757	-	7.00794	400.00000	HepG2	IGF2	3'-UTR,intron-Distal
GTF2F1	chr11	2153323	2153332	-	5.21895	400.00000	HepG2	IGF2	3'-UTR,intron-Distal
GTF2F1	chr11	2160350	2160354	-	3.87670	400.00000	HepG2	INS-IGF2, IGF2	5'-UTR,intron-Distal
GTF2F1	chr5	179049885	179049952	-	4.47768	43.83696	HepG2	HNRNPH1	intron-Distal,intron-Proximal
GTF2F1	chr2	183903011	183903106	-	5.65832	34.07410	HepG2	NCKAP1	5'-UTR,intron-Distal
GTF2F1	chr19	18548586	18548639	-	5.33267	28.83581	K562	ISYNA1	CDS,intron-Distal,intron-Proximal
GTF2F1	chr1	32403053	32403132	-	4.90865	26.13486	K562	PTP4A2	intron-Distal
GTF2F1	chr22	49990813	49990911	-	5.91763	24.15242	K562	C22orf34	intron-Distal
GTF2F1	chr15	66878820	66878870	+	5.07582	23.93200	K562	RP11-321F6.1	intron-Distal

Showing 1 to 10 of 100 entries

22 proteins are bound to GTF2F1 RNA:

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Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr19	6381368	6381482	-	CDS,intron-Distal,intron-Proximal	5.57699	31.55212	K562	UCHL5
chr19	6391912	6391914	-	CDS,intron-Distal,intron-Proximal	4.58811	27.37645	K562	YBX3
chr19	6389640	6389648	-	CDS,intron-Distal	4.94637	24.36083	K562	YBX3
chr19	6389634	6389640	-	CDS,intron-Distal	4.87895	23.05167	K562	YBX3
chr19	6391920	6391937	-	CDS,intron-Distal	4.44145	21.30146	K562	YBX3
chr19	6391914	6391920	-	CDS,intron-Distal	4.29570	19.26844	K562	YBX3
chr19	6381134	6381193	-	CDS,intron-Distal,intron-Proximal	4.81146	17.32647	K562	UCHL5
chr19	6389622	6389634	-	CDS,intron-Distal	4.52877	17.32535	K562	YBX3
chr19	6389456	6389637	-	CDS,intron-Distal	3.49422	15.62797	K562	UCHL5
chr19	6381369	6381466	-	CDS,intron-Distal,intron-Proximal	3.86199	15.61764	K562	ZNF622
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

Showing 1 to 10 of 80 entries

No autoregularoty interactions between protein GTF2F1 and its RNA.

Diffrential Expression

558 differentially expressed genes after Knockdown/Knockout GTF2F1 protein.

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87 RBPs can affect the levels of GTF2F1.

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558 differentially expressed genes after Knockdown/Knockout GTF2F1 protein :

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Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
HAL	ENSG00000084110.6	261.44230	916.84650	-1.81020	23.38180	19.31600	HepG2	GTF2F1
ASB4	ENSG00000005981.8	321.77460	77.28340	2.05770	18.37100	15.07800	HepG2	GTF2F1
SLC6A14	ENSG00000087916.7	420.82050	1134.20400	-1.43040	16.40200	13.21130	HepG2	GTF2F1
TIMP1	ENSG00000102265.7	860.02810	310.11900	1.47150	16.12180	12.96010	HepG2	GTF2F1
ACSM2B	ENSG00000066813.10	132.02830	423.23410	-1.68060	14.22440	11.21930	HepG2	GTF2F1
CYP24A1	ENSG00000019186.5	859.42980	343.99230	1.32090	13.26580	10.31400	HepG2	GTF2F1
APOH	ENSG00000091583.6	22636.81290	43932.64590	-0.95660	9.74830	7.08910	HepG2	GTF2F1
ARG2	ENSG00000081181.3	991.51520	482.48760	1.03900	9.21190	6.61600	HepG2	GTF2F1
TIMP2	ENSG00000035862.8	2563.08440	1329.49200	0.94690	9.18420	6.59550	HepG2	GTF2F1
HAMP	ENSG00000105697.3	96.86240	251.21300	-1.37490	8.51230	5.98100	HepG2	GTF2F1
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 100 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

87 RBPs can affect the gene expression of GTF2F1 :

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Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
GTF2F1	ENSG00000125651.9	899.01390	2023.88250	-1.17070	44.34720	42.49020	HepG2	ETF1
GTF2F1	ENSG00000125651.9	177.66800	1835.71740	-3.36910	43.10740	38.73950	K562	GTF2F1
GTF2F1	ENSG00000125651.9	2038.06070	1223.42880	0.73620	25.13700	23.71710	HepG2	PUM1
GTF2F1	ENSG00000125651.9	583.96760	1056.27800	-0.85500	19.63570	18.13620	HepG2	ZC3H8
GTF2F1	ENSG00000125651.9	1241.98000	754.86460	0.71830	15.22340	14.04920	HepG2	TRIM56
GTF2F1	ENSG00000125651.9	812.99680	1382.62260	-0.76610	14.58090	13.44300	HepG2	TAF15
GTF2F1	ENSG00000125651.9	1367.87760	2464.13950	-0.84910	14.22810	11.62020	K562	ABCF1
GTF2F1	ENSG00000125651.9	1663.02930	1137.92640	0.54730	10.57810	9.45970	HepG2	SRSF5
GTF2F1	ENSG00000125651.9	1818.36040	1294.13080	0.49060	10.43080	9.35430	HepG2	SUCLG1
GTF2F1	ENSG00000125651.9	650.07230	1115.62010	-0.77920	10.77390	9.12220	HepG2	HNRNPM
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 99 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

54 alternative splicing events after Knockdown/Knockout GTF2F1 protein :

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Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	FDR	is_included	Cell Line	Affected by RBP
SE	HIST1H2AC	ENSG00000180573.8	chr6	+	26127925	26127989	26124430	26124861	26138281	26139344	0.10300	0.00833	included	K562	GTF2F1
SE	PCGF3	ENSG00000185619.13	chr4	+	726232	726287	724758	724899	727460	727578	-0.39300	0.03810	excluded	K562	GTF2F1
SE	CALU	ENSG00000128595.12	chr7	+	128388626	128388858	128379345	128379486	128398924	128399091	-0.15600	0.00833	excluded	K562	GTF2F1
SE	FLNB	ENSG00000136068.10	chr3	+	58127584	58127656	58124008	58124256	58128376	58128479	0.14900	0.01691	included	HepG2	GTF2F1
SE	ANKRD11	ENSG00000167522.10	chr16	-	89358088	89358185	89357420	89357591	89371613	89371752	0.35000	0.01108	included	HepG2	GTF2F1
SE	GPR126	ENSG00000112414.10	chr6	+	142762044	142762090	142759348	142759501	142764473	142767403	0.15400	0.00173	included	HepG2	GTF2F1
SE	PRKAR1A	ENSG00000108946.10	chr17	+	66511127	66511260	66507920	66508283	66511534	66511717	0.08400	0.01268	included	HepG2	GTF2F1
SE	SETD5	ENSG00000168137.11	chr3	+	9494571	9494635	9490071	9490314	9495422	9495552	0.13400	0.01108	included	HepG2	GTF2F1
SE	NKD1	ENSG00000140807.4	chr16	+	50651663	50651716	50642204	50642271	50655512	50655619	0.07200	0.01691	included	HepG2	GTF2F1
RI	RBM6	ENSG00000004534.10	chr3	+	50098894	50099541	50098894	50098980	50099394	50099541	0.15000	0.00122	included	K562	GTF2F1

Showing 1 to 10 of 54 entries

6 RBPs can affect the splicing of GTF2F1 :

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Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	p-value	FDR	is_included	Cell Line	Affected by RBP
SE	GTF2F1	ENSG00000125651.9	chr19	-	6392213	6392421	6391912	6391985	6392867	6392914	0.17700	0.00000	0.00000	included	HepG2	PTBP1
A3SS	GTF2F1	ENSG00000125651.9	chr19	-	6383333	6383557	6383333	6383506	6387399	6387570	0.06800	0.00000	0.00000	longer	K562	AQR
A5SS	GTF2F1	ENSG00000125651.9	chr19	-	6387399	6387570	6387468	6387570	6383321	6383506	-0.15400	0.00000	0.00054	shorter	K562	HNRNPC
RI	GTF2F1	ENSG00000125651.9	chr19	-	6381369	6381626	6381369	6381489	6381564	6381626	0.08800	0.00000	0.00000	included	K562	PRPF8
RI	GTF2F1	ENSG00000125651.9	chr19	-	6380914	6381206	6380914	6381053	6381132	6381206	0.15600	0.00000	0.00000	included	K562	AQR
RI	GTF2F1	ENSG00000125651.9	chr19	-	6381369	6381626	6381369	6381489	6381564	6381626	0.09900	0.00000	0.00000	included	K562	AQR
SE	GTF2F1	ENSG00000125651.9	chr19	-	6392213	6392421	6391912	6391985	6392867	6392914	0.06500	0.00001	0.00058	included	K562	PTBP1
SE	GTF2F1	ENSG00000125651.9	chr19	-	6392213	6392421	6391912	6391985	6392867	6392914	0.05700	0.00114	0.07662	included	HepG2	DDX3X
RI	GTF2F1	ENSG00000125651.9	chr19	-	6380914	6381206	6380914	6381053	6381132	6381206	0.05600	0.00338	0.02494	included	HepG2	U2AF2

Showing 1 to 9 of 9 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

GTF2F1

General Information

Functions

Localization

Domains (AlphaFold: GTF2F1)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

GTF2F1 protein has 9,437 RNA targets:

22 proteins are bound to GTF2F1 RNA:

No autoregularoty interactions between protein GTF2F1 and its RNA.

Diffrential Expression

558 differentially expressed genes after Knockdown/Knockout GTF2F1 protein :

87 RBPs can affect the gene expression of GTF2F1 :

54 alternative splicing events after Knockdown/Knockout GTF2F1 protein :

6 RBPs can affect the splicing of GTF2F1 :

No autoregularoty alternative splicing events between protein GTF2F1 and its RNA.