HSF4

General Information

Gene Name       : HSF4
Gene ID             : ENSG00000102878.16
Essential Gene : No

Functions

Localization

Domains (AlphaFold: HSF4)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878HSF4ENSG00000102878.160.922.051.48ENCSR000AEF
HepG2HSF4ENSG00000102878.164.802.893.84ENCSR985KAT
K562HSF4ENSG00000102878.169.236.217.72ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for HSF4 is not avaliable on ENCORE database.



Proteins bound to RNA
  • HSF4 RNA is bound by 22 proteins.  







eCLIP assay for HSF4 is not avaliable on ENCORE database.





22 proteins are bound to HSF4 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr166720103967201076+3'-UTR,5'-UTR,CDS,intron-Proximal3.400533.73423K562UCHL5
chr166720143567201500+3'-UTR,5'-UTR,CDS,intron-Distal4.6429212.12719K562DDX24
chr166720280367202835+3'-UTR,CDS3.926288.55049K562DDX24
chr166720184667201893+3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal5.247596.83960K562AQR
chr166720293867203003+3'-UTR,CDS,intron-Proximal4.035694.41267HepG2PPIG
chr166720129467201358+3'-UTR,CDS,intron-Distal,intron-Proximal4.5878417.99581K562DDX24
chr166720362367203759+3'-UTR,CDS,intron-Proximal4.427315.03717HepG2PABPN1
chr166720143867201503+3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal4.767183.79199HepG2PPIG
chr166720293867202978+3'-UTR,CDS,intron-Proximal4.548265.29868K562UCHL5
chr166720293867202981+3'-UTR,CDS,intron-Proximal4.1600314.25229K562DDX24
chr166720102667201061+3'-UTR,5'-UTR,CDS,intron-Proximal3.970443.20743HepG2PPIG
chr166720121767201254+3'-UTR,CDS,intron-Distal,intron-Proximal5.9145010.14153K562DDX24
chr166720293867202995+3'-UTR,CDS,intron-Proximal3.605955.95375K562ZNF622
chr166720294267203021+3'-UTR,CDS,intron-Proximal4.502776.01740K562SRSF1
chr166720280467202827+3'-UTR,CDS4.395834.16170K562UCHL5
chr166720142767201497+3'-UTR,5'-UTR,CDS,intron-Distal3.099955.76422K562UCHL5
chr166720109667201124+3'-UTR,5'-UTR,CDS,intron-Proximal3.302114.14618K562ZNF622
chr166720172867201760+3'-UTR,5'-UTR,CDS,intron-Distal3.452705.65306K562ZNF622
chr166720178067201851+3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal3.930287.13692K562ZNF622
chr166720107467201101+3'-UTR,5'-UTR,CDS,intron-Proximal3.759995.69590K562DDX24
chr166719849067198582+3'-UTR,5'-UTR,intron-Distal4.365105.04359K562HNRNPK
chr166719963167199692+3'-UTR,5'-UTR,CDS3.147446.45164K562BUD13
chr166720047767200523+5'-UTR,CDS,intron-Proximal4.068366.61895K562ZNF622
chr166720047367200520+5'-UTR,CDS,intron-Proximal4.591935.27053HepG2PPIG
chr166720046767200503+5'-UTR,CDS,intron-Proximal6.4002114.40582K562DDX24
chr166720022967200271+5'-UTR,CDS3.153046.55915K562BUD13
chr166720011467200261+5'-UTR,CDS,intron-Distal,intron-Proximal3.6597019.54927K562AQR
chr166719857567198656+3'-UTR,5'-UTR,intron-Distal3.301323.41531HepG2RBFOX2
chr166720011467200229+5'-UTR,CDS,intron-Distal,intron-Proximal3.8021325.35629K562BUD13
chr166719865467198696+3'-UTR,5'-UTR,intron-Distal4.247314.48994K562RBM15
chr166720019267200263+5'-UTR,CDS,intron-Proximal5.4037141.61748K562SF3B4
chr166720017067200227+5'-UTR,CDS,intron-Proximal3.857985.22697HepG2SF3B4
chr166720023167200283+5'-UTR,CDS,intron-Proximal3.313733.32039HepG2PPIG
chr166719852767198578+3'-UTR,5'-UTR,intron-Distal4.169403.81597K562RBM15
chr166719723367197296+5'-UTR,CDS,intron-Distal4.429266.37184K562RBM15
chr166720011667200228+5'-UTR,CDS,intron-Distal,intron-Proximal4.3444633.69133K562DDX24
chr166719733067197430+5'-UTR,CDS,intron-Distal,intron-Proximal4.859695.97170HepG2RBM15
chr166720022867200286+5'-UTR,CDS,intron-Proximal5.8941718.79083K562DDX24
chr166719883567198921+3'-UTR,CDS,intron-Distal,intron-Proximal4.220933.82414HepG2HNRNPK
chr166719952967199590+3'-UTR,CDS,intron-Proximal3.433823.51298K562AKAP8L
chr166719955267199634+3'-UTR,CDS,intron-Proximal4.378398.91093K562PRPF8
chr166719953267199615+3'-UTR,CDS,intron-Proximal3.150117.34413K562BUD13
chr166720000967200086+intron-Distal,intron-Proximal5.1623310.40873K562GTF2F1
chr166720067667200822+intron-Distal4.596976.11268HepG2HNRNPK
chr166720011567200170+intron-Distal,intron-Proximal3.192913.60305HepG2SF3B4
chr166720000567200075+intron-Distal,intron-Proximal3.8220219.37860K562SF3B4
chr166720000867200087+intron-Distal,intron-Proximal3.185104.01873K562UCHL5
chr166719898167199049+3'-UTR,intron-Distal4.064043.71802K562RBFOX2
chr166719911867199179+3'-UTR,intron-Distal3.216235.37652K562BUD13
chr166720009067200201+intron-Distal,intron-Proximal3.751083.51682HepG2RBFOX2
chr166720000367200059+intron-Distal,intron-Proximal4.3091410.23668K562AKAP8L
chr166720000767200068+intron-Distal,intron-Proximal4.2486016.66888K562EFTUD2
chr166719999667200071+intron-Distal,intron-Proximal5.0238017.02742K562AQR
chr166720000067200091+intron-Distal,intron-Proximal3.8967314.20147K562RBFOX2
chr166720012467200204+intron-Distal,intron-Proximal3.079715.43751K562GTF2F1
chr166720131767201348+intron-Distal,intron-Proximal3.659485.85504K562SF3B4
chr166719920367199262+3'-UTR,intron-Distal3.684886.90700K562BUD13
chr166720008467200169+intron-Distal,intron-Proximal3.2352411.81571K562PRPF8
chr166719921667199261+3'-UTR,intron-Distal3.654284.50825K562DDX24
chr166720000667200075+intron-Distal,intron-Proximal3.620047.35479K562MTPAP
chr166719899167199019+3'-UTR,intron-Distal4.344633.00996K562BUD13
chr166719999467200066+intron-Distal,intron-Proximal4.049713.56104K562CPSF6
chr166720000167200092+intron-Distal,intron-Proximal6.2872133.86437K562DDX24
chr166719999667200089+intron-Distal,intron-Proximal3.8665419.53991K562BUD13
chr166720001367200070+intron-Distal,intron-Proximal3.263923.73688K562SMNDC1
chr166720113667201190+intron-Proximal3.103473.75792K562U2AF2
chr166720114267201203+intron-Proximal3.804739.80165K562TIA1
chr166720013867200216+intron-Proximal3.942733.68924HepG2PRPF4
chr166720016667200192+intron-Proximal5.5449436.31026K562SF3B4
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for HSF4 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for HSF4 is not available on ENCORE database.

  • 72 RBPs can affect the levels of HSF4.  








The Knockdown/knockout RNA-Seq assay for HSF4 is not available on ENCORE database.





72 RBPs can affect the gene expression of HSF4 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
HSF4ENSG00000102878.1179.05100181.32090-1.197706.853205.98270HepG2ACO1
HSF4ENSG00000102878.11125.04710182.12670-0.542502.347901.63520HepG2AKAP8L
HSF4ENSG00000102878.11214.60120106.024001.017204.872103.56540HepG2CCAR1
HSF4ENSG00000102878.11125.72600181.22600-0.527502.315001.69780HepG2CKAP4
HSF4ENSG00000102878.11106.28180190.28560-0.840302.238401.55590HepG2CNOT7
HSF4ENSG00000102878.11103.7628035.661801.540705.949104.97540HepG2CPSF6
HSF4ENSG00000102878.1172.62230167.67040-1.207106.844005.62390HepG2DDX19B
HSF4ENSG00000102878.11181.7896092.445900.975503.441502.75310HepG2DDX3X
HSF4ENSG00000102878.11171.78570264.08500-0.620403.211001.82230HepG2DDX47
HSF4ENSG00000102878.11268.5086079.471501.7564013.5201012.28240HepG2DDX6
HSF4ENSG00000102878.11102.77310173.46070-0.755103.503602.75490HepG2DKC1
HSF4ENSG00000102878.11119.2094071.395200.739502.653401.96110HepG2DNAJC21
HSF4ENSG00000102878.1154.2192098.99140-0.868502.361401.50760HepG2EEF2
HSF4ENSG00000102878.11324.7148076.339802.0886021.4725019.92820HepG2EIF2S1
HSF4ENSG00000102878.11135.2840084.336300.681701.921401.38430HepG2EIF4A3
HSF4ENSG00000102878.11184.3526078.969301.223004.254103.43760HepG2G3BP1
HSF4ENSG00000102878.11101.3844040.420801.326604.294103.50820HepG2GPKOW
HSF4ENSG00000102878.11115.2399067.076500.780702.546501.85780HepG2HNRNPF
HSF4ENSG00000102878.11206.1620080.068101.364408.052306.91090HepG2HNRNPK
HSF4ENSG00000102878.11209.21000117.758800.829003.060602.35340HepG2HNRNPL
HSF4ENSG00000102878.11156.97890260.09050-0.728402.569401.38950HepG2HSPD1
HSF4ENSG00000102878.11107.5654066.049500.703501.947001.33110HepG2IGF2BP1
HSF4ENSG00000102878.11142.4798081.362600.808203.817102.96960HepG2ILF2
HSF4ENSG00000102878.11189.41900128.200400.563102.633001.88940HepG2NOL12
HSF4ENSG00000102878.11291.30590173.989700.743403.095802.15420HepG2PABPC1
HSF4ENSG00000102878.11180.2611078.030201.207906.370605.28630HepG2PABPC4
HSF4ENSG00000102878.11109.3023071.043600.621401.966501.33630HepG2PPIL4
HSF4ENSG00000102878.11118.8513069.255700.779102.804402.25370HepG2PTBP1
HSF4ENSG00000102878.11195.72060129.828900.592102.706102.04270HepG2PUM2
HSF4ENSG00000102878.11111.34830184.67900-0.729903.835603.13360HepG2PUS1
HSF4ENSG00000102878.1123.1009063.61170-1.461302.930002.20630HepG2RAVER1
HSF4ENSG00000102878.11129.9315077.072700.753402.558002.03480HepG2NELFE
HSF4ENSG00000102878.11136.2349071.786800.924203.775003.06990HepG2RECQL
HSF4ENSG00000102878.1125.1395058.30190-1.213602.315301.58910HepG2RRP9
HSF4ENSG00000102878.11130.2109062.104701.068003.044801.36480HepG2SLTM
HSF4ENSG00000102878.11130.0438064.979301.000803.930902.77140HepG2SMNDC1
HSF4ENSG00000102878.11110.94890170.77480-0.622202.629302.13590HepG2SRFBP1
HSF4ENSG00000102878.1142.9015075.25810-0.810801.747501.34710HepG2SRSF1
HSF4ENSG00000102878.1176.15080120.85260-0.666302.042701.49510HepG2SRSF5
HSF4ENSG00000102878.11153.4305062.155701.303507.664406.28780HepG2TIA1
HSF4ENSG00000102878.11152.6534077.361000.980504.681304.06560HepG2TIAL1
HSF4ENSG00000102878.11174.3512078.093501.158606.252805.46650HepG2TRIM56
HSF4ENSG00000102878.1132.28430108.75640-1.752207.304406.29070HepG2U2AF1
HSF4ENSG00000102878.11108.7013044.963201.273504.494403.52610HepG2UCHL5
HSF4ENSG00000102878.11212.6827099.512001.095703.307002.55450HepG2UPF1
HSF4ENSG00000102878.11164.5301069.664501.239803.832102.63740HepG2UPF2
HSF4ENSG00000102878.11151.8827074.950901.018802.976302.22390HepG2XRN2
HSF4ENSG00000102878.11109.59850180.84120-0.722502.835101.63930K562AARS
HSF4ENSG00000102878.11651.14800508.794100.355802.264501.67070K562AKAP8L
HSF4ENSG00000102878.11213.79140128.203100.737703.125002.29040K562CPSF6
HSF4ENSG00000102878.11524.76100391.449300.422703.023601.75770K562DDX21
HSF4ENSG00000102878.11267.86930353.72260-0.401102.462201.84250K562DDX47
HSF4ENSG00000102878.11420.67600319.771300.395602.448901.76490K562EIF2S2
HSF4ENSG00000102878.11694.95060542.063000.358302.314501.45050K562EIF4G2
HSF4ENSG00000102878.11199.41640272.42390-0.450102.276401.71880K562FXR1
HSF4ENSG00000102878.1127.6576097.95740-1.824507.179805.92730K562G3BP2
HSF4ENSG00000102878.11448.36330343.397300.384702.283801.31350K562HNRNPA1
HSF4ENSG00000102878.11291.49510176.707500.722004.283802.82650K562HNRNPF
HSF4ENSG00000102878.11283.46210187.877200.593302.656401.65720K562IGF2BP2
HSF4ENSG00000102878.11270.33720197.342500.454002.072801.34050K562MAGOH
HSF4ENSG00000102878.11280.90560196.925500.512302.765301.84250K562MATR3
HSF4ENSG00000102878.11456.33440349.256000.385702.902102.14070K562NSUN2
HSF4ENSG00000102878.11325.24550194.830800.739203.568601.87250K562NUSAP1
HSF4ENSG00000102878.11393.14130242.524200.696802.353501.45500K562PABPN1
HSF4ENSG00000102878.11296.26430193.193800.616703.113401.58810K562PHF6
HSF4ENSG00000102878.11537.52750376.296300.514403.250901.55200K562PKM
HSF4ENSG00000102878.11186.25590277.65410-0.576003.079502.23290K562POLR2G
HSF4ENSG00000102878.11528.89300288.290800.875403.463601.76960K562PPP1R8
HSF4ENSG00000102878.11317.96480177.423000.841605.803204.41940K562PSIP1
HSF4ENSG00000102878.11406.58410591.40340-0.540604.351803.33420K562PUF60
HSF4ENSG00000102878.11165.78260255.76040-0.625503.060001.53390K562SDAD1
HSF4ENSG00000102878.11471.23710270.323900.801702.973701.60050K562SFPQ
HSF4ENSG00000102878.11252.93440153.449800.720903.753402.50590K562SRFBP1
HSF4ENSG00000102878.11302.23430203.122200.573202.869101.79170K562SRSF4
HSF4ENSG00000102878.11292.42630177.563400.719603.110901.98680K562SRSF5
HSF4ENSG00000102878.11137.58050278.48020-1.017307.875006.47690K562SYNCRIP
HSF4ENSG00000102878.11394.46300190.221801.052109.667408.21840K562TARDBP
HSF4ENSG00000102878.11321.30930183.497300.808105.920304.65350K562TIA1
HSF4ENSG00000102878.11329.57330170.651800.949406.588905.08950K562TIAL1
HSF4ENSG00000102878.11272.58640180.127900.597603.147101.97040K562TRA2A
HSF4ENSG00000102878.11322.17300181.290400.829405.672404.20210K562TRIM56
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for HSF4 is not available on ENCORE database.





12 RBPs can affect the splicing of HSF4 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEHSF4ENSG00000102878.11chr16+672012056720130567201022672011256720137767201502-0.213000.003580.05825excludedK562SRSF1
SEHSF4ENSG00000102878.11chr16+672012056720130567201022672011256720137767201502-0.202000.000630.02600excludedK562TARDBP
SEHSF4ENSG00000102878.11chr16+672012056720130567201022672011256720137767201502-0.498000.000790.03198excludedHepG2HNRNPC
SEHSF4ENSG00000102878.11chr16+672012056720130567201022672011256720137767201502-0.355000.000000.00000excludedK562HNRNPC
A5SSHSF4ENSG00000102878.11chr16+6720046067200698672004606720052567201022672011250.086000.000030.00481longerK562AGGF1
RIHSF4ENSG00000102878.11chr16+671994246719974967199424671995336719962167199749-0.292000.000110.00087excludedK562AQR
MXEHSF4ENSG00000102878.11chr16+6720137767201502672017266720185067201022672011256720273367202839-0.235000.002560.062852includedK562UCHL5
MXEHSF4ENSG00000102878.11chr16+6720137767201502672017266720185067201205672013056720273367202839-0.147000.000670.023982includedK562UCHL5
MXEHSF4ENSG00000102878.11chr16+6720137767201502672017266720185067201022672011256720273367202839-0.377000.001160.048912includedHepG2BCCIP
MXEHSF4ENSG00000102878.11chr16+6720137767201502672017266720185067201022672011256720273367202839-0.223000.003840.085552includedK562EFTUD2
MXEHSF4ENSG00000102878.11chr16+6720137767201502672017266720185067201205672013056720273367202839-0.236000.002950.065572includedHepG2XRN2
MXEHSF4ENSG00000102878.11chr16+6720120567201305672013776720150267201022672011256720172667201850-0.371000.002110.059772includedHepG2HNRNPC
MXEHSF4ENSG00000102878.11chr16+67201377672015026720172667201850672010226720112567202733672028390.366000.000060.002151includedK562HNRNPC
MXEHSF4ENSG00000102878.11chr16+6720120567201305672013776720150267201022672011256720172667201850-0.384000.000000.000022includedK562HNRNPC
MXEHSF4ENSG00000102878.11chr16+6720120567201305672013636720150267201022672011256720172667201850-0.511000.000020.000962includedK562HNRNPC
MXEHSF4ENSG00000102878.11chr16+6720120567201305672013876720150267201022672011256720172667201850-0.461000.000370.009212includedK562HNRNPC
MXEHSF4ENSG00000102878.11chr16+6720137767201502672017266720185067201022672011256720273367202839-0.236000.002230.048812includedHepG2HNRNPK
MXEHSF4ENSG00000102878.11chr16+6720137767201502672017266720185067201022672011256720273367202839-0.361000.006660.080872includedK562SF3B4
MXEHSF4ENSG00000102878.11chr16+6720137767201502672017266720185067201022672011256720273367202839-0.276000.001020.024612includedK562SUPV3L1

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for HSF4 is not avaliable on ENCORE database.