ACO1

General Information

Gene Name : ACO1
Gene ID : ENSG00000122729.18
Essential Gene : No

Functions

RNA stability & decay
Translation regulation

Localization(RBPImage: ACO1)

Nuclei
Nucleoplasm
Mutually Exclusive from Nucleolus
PML bodies
Unknown Nuclear Foci
Cytoplasm
Cytosolic

Domains (AlphaFold: ACO1)

No checked domain (RRM, ZNF, KH, Helicase, Nuclease, dRBM or PUM_HD)

Antibody Validation

MBLI: RN036PW

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	ACO1	ENSG00000122729.18	2.09	2.41	2.25	ENCSR000AEF
HepG2	ACO1	ENSG00000122729.18	22.52	27.04	24.78	ENCSR985KAT
K562	ACO1	ENSG00000122729.18	13.82	15.21	14.52	ENCSR000AEO

Assays

2 Released experiments are available on ENCORE database.

Assay Type	Exp_Name	ENCODE ID	Target label	Biosample	Status	Linked Antibody	Controls	Method	Note
knockdown followed by RNA-seq	ACO1-BGHLV31-HepG2	ENCSR511SYK	ACO1	HepG2	Released		ENCSR538QOG	shRNA	KD% = 58.8,50.3
knockdown followed by RNA-seq	ACO1-BGKcLV11-K562	ENCSR237QLO	ACO1	K562	Released		ENCSR292PXV	CRISPR	KD% = 55.7,64.5

eCLIP

No eCLIP experiment available

Antibody Validation

GeneName	Antibody_DCC_ID	Product_ID	Lot_ID	Phosphate	HepG2 Primary Validation	K562 Primary Validation	HepG2 Secondary Validation	K562 Secondary Validation
ACO1	ENCAB923LQZ	RN036PW	1			Released, ENCODE3	BGHLV31-5, Released, ENCODE3	BGKcLV11-3, Released, ENCODE4

KD RNA-Seq

GeneName	Cell_Line	Method	Exp_ID	Control_ID	Sample_reps	Control_reps	KD%	Status	Project
ACO1	HepG2	shRNA			BGHLV27-3,BGHLV27-4	BGHLV27-1,BGHLV27-2		NotSatisfied	ENCODE3
ACO1	HepG2	shRNA	ENCSR511SYK	ENCSR538QOG	ACO1_BGHLV31-5,ACO1_BGHLV31-6	NT-BGHLV31-1,NT-BGHLV31-2	58.8,50.3	Released	ENCODE3
ACO1	K562	CRISPR	ENCSR237QLO	ENCSR292PXV	ACO1-BGKcLV11-3,ACO1-BGKcLV11-4	NT-BGKcLV11-1,NT-BGKcLV11-2	55.7,64.5	Released	ENCODE4
ACO1	K562	CRISPR			BGKcLV11-5,BGKcLV11-6	BGKcLV11-1,BGKcLV11-2	36.0,28.4	NotSatisfied	ENCODE4

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

ACO1: Click to RBP Image Database

Nuclei

Nucleoplasm

Mutually Exclusive from Nucleolus

PML bodies

Unknown Nuclear Foci

Cytoplasm

Cytosolic

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela
ACO1	Product_ID: RN036PW Lot_ID: 1 Source: MBLI Target Name: ACO1-human

Summary
Proteins Bound to RBP RNA

RNA Targets

eCLIP assay for ACO1 is not avaliable on ENCORE database.

Proteins bound to RNA

ACO1 RNA is bound by 4 proteins.

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eCLIP assay for ACO1 is not avaliable on ENCORE database.

4 proteins are bound to ACO1 RNA:

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Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr9	32408514	32408550	+	5'-UTR,CDS	3.65640	12.44888	K562	YBX3
chr9	32408510	32408514	+	5'-UTR,CDS,intron-Proximal	3.90307	11.04556	K562	YBX3
chr9	32407404	32407427	+	5'-UTR,CDS	3.69307	8.67507	K562	YBX3
chr9	32424553	32424608	+	CDS	4.39189	8.47938	HepG2	BCLAF1
chr9	32419036	32419077	+	CDS	4.90432	5.23259	HepG2	BCLAF1
chr9	32450687	32450749	+	3'-UTR	4.70223	4.66187	HepG2	SUB1
chr9	32429420	32429465	+	CDS	3.02688	4.61799	HepG2	BCLAF1
chr9	32384659	32384734	+	5'-UTR,intron-Proximal	3.70024	3.33524	K562	DDX3X
chr9	32436260	32436296	+	CDS	3.57688	3.01531	K562	YBX3
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

Showing 1 to 9 of 9 entries

eCLIP assay for ACO1 is not avaliable on ENCORE database.

Diffrential Expression

7,360 differentially expressed genes after Knockdown/Knockout ACO1 protein.

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77 RBPs can affect the levels of ACO1.

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7,360 differentially expressed genes after Knockdown/Knockout ACO1 protein :

Only display 100 entries as example. Please click "View All" button to see all 7,360 entries.

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Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
SLC7A2	ENSG00000003989.12	2162.77300	7322.40380	-1.75940	179.74300	176.93340	HepG2	ACO1
MYH16	ENSG00000002079.8	468.40790	5.98380	6.29050	123.75100	121.27080	HepG2	ACO1
ITGA3	ENSG00000005884.13	1091.05560	70.73630	3.94700	114.97330	112.56390	HepG2	ACO1
CX3CL1	ENSG00000006210.6	997.32630	2720.21420	-1.44760	85.44810	83.31080	HepG2	ACO1
ASB4	ENSG00000005981.8	548.27680	64.76960	3.08140	79.23690	77.15140	HepG2	ACO1
TNFRSF12A	ENSG00000006327.9	2074.39960	812.16610	1.35270	64.52770	62.57800	HepG2	ACO1
RPS20	ENSG00000008988.5	3422.16960	6755.35620	-0.98110	60.81540	58.89390	HepG2	ACO1
CYP51A1	ENSG00000001630.11	2841.46050	5479.84470	-0.94750	53.55730	51.71730	HepG2	ACO1
BAIAP2L1	ENSG00000006453.9	1673.66960	730.47130	1.19600	46.06530	44.34260	HepG2	ACO1
DBNDD1	ENSG00000003249.9	1818.86480	848.76530	1.09950	41.96070	40.27830	HepG2	ACO1
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 100 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

77 RBPs can affect the gene expression of ACO1 :

Show entries

Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
ACO1	ENSG00000122729.14	503.10040	1109.48120	-1.14100	32.97370	31.43340	HepG2	ACO1
ACO1	ENSG00000122729.14	2506.21170	1428.75040	0.81070	27.68490	26.44140	HepG2	SSB
ACO1	ENSG00000122729.14	765.99570	1392.74770	-0.86250	25.38960	23.56630	HepG2	HNRNPL
ACO1	ENSG00000122729.14	534.96820	1092.95180	-1.03070	18.43200	16.63210	K562	SRSF1
ACO1	ENSG00000122729.14	1017.40460	1536.22200	-0.59450	14.88200	13.73340	HepG2	PUM1
ACO1	ENSG00000122729.14	311.54320	680.74810	-1.12770	14.26410	12.57290	HepG2	UCHL5
ACO1	ENSG00000122729.14	956.50030	1540.45340	-0.68750	11.88420	10.72300	HepG2	QKI
ACO1	ENSG00000122729.14	669.05110	1044.61300	-0.64280	10.61820	9.13690	HepG2	PARN
ACO1	ENSG00000122729.14	745.14990	1096.01480	-0.55670	10.17990	9.07180	HepG2	SMN1
ACO1	ENSG00000122729.14	1158.33440	1645.56450	-0.50650	9.77300	8.98820	HepG2	SRFBP1
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 84 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

The Knockdown/knockout RNA-Seq assay for ACO1 is not available on ENCORE database.

3 RBPs can affect the splicing of ACO1 :

Show entries

Search:

Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	p-value	FDR	is_included	Cell Line	Affected by RBP
SE	ACO1	ENSG00000122729.14	chr9	+	32386368	32386436	32384617	32384733	32405482	32405601	-0.14900	0.00004	0.01822	excluded	HepG2	BCLAF1
SE	ACO1	ENSG00000122729.14	chr9	+	32386368	32386436	32384617	32384733	32405482	32405601	-0.14900	0.00004	0.01443	excluded	HepG2	DDX55
SE	ACO1	ENSG00000122729.14	chr9	+	32386368	32386436	32384617	32384733	32405482	32405601	0.19300	0.00049	0.01414	included	HepG2	SRSF1

Showing 1 to 3 of 3 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

ACO1

General Information

Functions

Localization(RBPImage: ACO1)

Domains (AlphaFold: ACO1)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

eCLIP assay for ACO1 is not avaliable on ENCORE database.

4 proteins are bound to ACO1 RNA:

eCLIP assay for ACO1 is not avaliable on ENCORE database.

Diffrential Expression

7,360 differentially expressed genes after Knockdown/Knockout ACO1 protein :

77 RBPs can affect the gene expression of ACO1 :

The Knockdown/knockout RNA-Seq assay for ACO1 is not available on ENCORE database.

3 RBPs can affect the splicing of ACO1 :

The Knockdown/knockout RNA-Seq assay for ACO1 is not avaliable on ENCORE database.