LIG3

General Information

Gene Name       : LIG3
Gene ID             : ENSG00000005156.11
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: LIG3)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878LIG3ENSG00000005156.1122.8721.3322.10ENCSR000AEF
HepG2LIG3ENSG00000005156.1134.0023.7828.89ENCSR985KAT
K562LIG3ENSG00000005156.1129.1328.9129.02ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for LIG3 is not avaliable on ENCORE database.



Proteins bound to RNA
  • LIG3 RNA is bound by 13 proteins.  







eCLIP assay for LIG3 is not avaliable on ENCORE database.





13 proteins are bound to LIG3 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr173332531433325329+3'-UTR,CDS,intron-Proximal4.300456.99120K562AQR
chr173331648233316542+3'-UTR,CDS,intron-Proximal3.302494.11795K562YBX3
chr173332527933325377+3'-UTR,CDS,intron-Proximal4.7665515.12562HepG2PRPF8
chr173333182033331919+3'-UTR,polyA_site3.403906.00918K562FAM120A
chr173332561533325696+3'-UTR,CDS,intron-Proximal4.452945.23727HepG2G3BP1
chr173332566033325742+3'-UTR,CDS3.274497.44928HepG2PPIG
chr173331024733310310+5'-UTR,CDS,intron-Distal,intron-Proximal3.009303.39306HepG2GRWD1
chr173331950533319563+CDS,intron-Proximal5.453536.22530K562AQR
chr173332682933326875+CDS4.761506.16445HepG2PPIG
chr173332469833324771+CDS,intron-Proximal4.607258.25856K562SF3B4
chr173332482433324910+CDS,intron-Proximal4.184887.35008K562PRPF8
chr173332127533321325+CDS,intron-Proximal3.095923.49021K562U2AF2
chr173331878933318836+CDS3.395613.66187K562ZNF622
chr173331877333318829+CDS3.764124.17155HepG2BCLAF1
chr173332894133329124+CDS,intron-Proximal3.676674.47362HepG2G3BP1
chr173332827333328296+CDS,intron-Proximal4.106213.49332HepG2PPIG
chr173331910133319156+intron-Distal,intron-Proximal5.346026.75320K562AQR
chr173330772433307766+intron-Distal,intron-Proximal4.230543.18269HepG2XPO5
chr173332281033322880+intron-Distal4.137116.86842HepG2U2AF2
chr173332664533326712+intron-Distal,intron-Proximal4.311473.80506K562RBFOX2
chr173331911333319210+intron-Distal,intron-Proximal4.888926.80771K562PRPF8
chr173332298933323063+intron-Proximal5.195319.41491HepG2SF3B4
chr173332575333325813+intron-Proximal4.888894.48002K562AQR
chr173332299633323078+intron-Proximal6.1541611.49904K562SF3B4
chr173332532933325363+intron-Proximal5.392348.03507K562AQR
chr173331905433319101+intron-Proximal5.676739.95272K562AQR
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for LIG3 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for LIG3 is not available on ENCORE database.

  • 130 RBPs can affect the levels of LIG3.  








The Knockdown/knockout RNA-Seq assay for LIG3 is not available on ENCORE database.





130 RBPs can affect the gene expression of LIG3 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
LIG3ENSG00000005156.7448.11940758.55570-0.759405.304502.99980HepG2AARS
LIG3ENSG00000005156.7552.17680776.88050-0.492606.075405.24470HepG2ACO1
LIG3ENSG00000005156.7508.32330672.96200-0.404802.551301.59350HepG2ADAR
LIG3ENSG00000005156.7609.61540935.23490-0.617405.135903.73260HepG2AKAP8
LIG3ENSG00000005156.7554.96660780.45550-0.491905.695004.63130HepG2AKAP8L
LIG3ENSG00000005156.7513.43870729.26680-0.506303.520102.63580HepG2ASCC1
LIG3ENSG00000005156.7722.265001268.56770-0.8126017.8247016.36310HepG2AUH
LIG3ENSG00000005156.7490.75360773.93620-0.657205.227303.93340HepG2BCCIP
LIG3ENSG00000005156.7335.33810672.42640-1.0038010.588908.97400HepG2BCLAF1
LIG3ENSG00000005156.7701.309301096.14510-0.644307.129706.22180HepG2BOP1
LIG3ENSG00000005156.7568.43830869.68780-0.613504.660703.07760HepG2BUD13
LIG3ENSG00000005156.7522.22540808.97380-0.631406.823005.68440HepG2CALR
LIG3ENSG00000005156.7425.48740692.86190-0.703506.024104.91390HepG2CIRBP
LIG3ENSG00000005156.7521.58410776.62150-0.574308.264307.23370HepG2CKAP4
LIG3ENSG00000005156.7730.923601006.31440-0.461303.614202.83910HepG2CPSF6
LIG3ENSG00000005156.7705.86860955.97690-0.437603.393302.17020HepG2CPSF7
LIG3ENSG00000005156.7491.32370690.11970-0.490204.797603.45930HepG2YBX3
LIG3ENSG00000005156.7559.95290906.60600-0.6952010.148309.06660HepG2CELF1
LIG3ENSG00000005156.7578.40600718.46170-0.312802.969702.10730HepG2DDX19B
LIG3ENSG00000005156.7476.96090711.93310-0.577903.722502.25940HepG2DDX27
LIG3ENSG00000005156.7284.81010844.26890-1.5677024.7902023.11030HepG2DDX3X
LIG3ENSG00000005156.7527.90850760.97320-0.527603.664802.78850HepG2DDX55
LIG3ENSG00000005156.7520.31730725.37280-0.479302.845302.21960HepG2DDX6
LIG3ENSG00000005156.7593.56450743.24080-0.324402.672002.00530HepG2DKC1
LIG3ENSG00000005156.7555.09750671.66920-0.275002.259101.65710HepG2DNAJC2
LIG3ENSG00000005156.7392.52850563.03750-0.520402.870601.74150HepG2AGO1
LIG3ENSG00000005156.7537.55490697.19110-0.375102.054901.53520HepG2EIF2S1
LIG3ENSG00000005156.7438.97440770.41650-0.811507.322006.28250HepG2EIF4A3
LIG3ENSG00000005156.7696.32400961.71060-0.465805.337504.23780HepG2EIF4G1
LIG3ENSG00000005156.7717.654601456.54420-1.0212029.1701027.56830HepG2ETF1
LIG3ENSG00000005156.7521.32500759.07100-0.542105.055603.93020HepG2EWSR1
LIG3ENSG00000005156.7376.09880513.27680-0.448603.259701.97830HepG2FAM120A
LIG3ENSG00000005156.7751.174801171.82900-0.641504.767303.77950HepG2FIP1L1
LIG3ENSG00000005156.7376.15260633.35640-0.751706.369404.52530HepG2FKBP4
LIG3ENSG00000005156.7439.110401008.05290-1.198906.604105.04030HepG2FTO
LIG3ENSG00000005156.7514.14950721.15130-0.488103.153602.44510HepG2G3BP1
LIG3ENSG00000005156.7644.931701140.71780-0.822708.742507.64740HepG2GPKOW
LIG3ENSG00000005156.7561.38550741.64380-0.401704.169402.98500HepG2HDGF
LIG3ENSG00000005156.7434.10320684.12240-0.656205.930605.03350HepG2HNRNPA1
LIG3ENSG00000005156.7362.09850760.96720-1.0715014.0222012.57720HepG2HNRNPC
LIG3ENSG00000005156.7823.155301125.34640-0.451106.045405.04020HepG2HNRNPF
LIG3ENSG00000005156.7746.02170887.86210-0.251102.130601.52930HepG2HNRNPL
LIG3ENSG00000005156.7523.004601088.60970-1.0576014.8555013.55720HepG2HNRNPLL
LIG3ENSG00000005156.7553.04160755.93560-0.450905.033904.23610HepG2HNRNPU
LIG3ENSG00000005156.7756.955501018.32570-0.427902.530701.35900HepG2HSPD1
LIG3ENSG00000005156.7742.845501108.14570-0.577007.252306.12980HepG2IGF2BP1
LIG3ENSG00000005156.7478.72560732.99960-0.614604.912504.03580HepG2IGF2BP2
LIG3ENSG00000005156.7791.436601298.18910-0.714006.155404.90740HepG2LARP4
LIG3ENSG00000005156.7531.57630777.77670-0.549104.029803.23990HepG2MAGOH
LIG3ENSG00000005156.7713.724701110.27960-0.637504.106102.91590HepG2MTPAP
LIG3ENSG00000005156.7584.72100800.49760-0.453102.920702.27160HepG2NCBP2
LIG3ENSG00000005156.7713.98790966.53460-0.436904.281103.33250HepG2NOL12
LIG3ENSG00000005156.7737.90240965.27370-0.387502.744901.99980HepG2NSUN2
LIG3ENSG00000005156.7366.80290575.07380-0.648703.128902.18180HepG2PABPC1
LIG3ENSG00000005156.7526.70980778.30450-0.563307.006106.11280HepG2PCBP1
LIG3ENSG00000005156.7295.68360670.54170-1.1813010.711708.85830HepG2PCBP2
LIG3ENSG00000005156.7796.234401053.49880-0.403904.718203.73740HepG2PRPF4
LIG3ENSG00000005156.7266.98860586.85190-1.1362012.4933010.94710HepG2PRPF8
LIG3ENSG00000005156.7550.95890791.97000-0.523505.408604.69790HepG2PTBP1
LIG3ENSG00000005156.7482.74450922.67110-0.9346013.1676011.99660HepG2PUF60
LIG3ENSG00000005156.71181.50120979.490300.270403.436602.79020HepG2PUM1
LIG3ENSG00000005156.7540.37450791.29000-0.550207.419806.49220HepG2PUS1
LIG3ENSG00000005156.7430.568401217.38920-1.4995041.9728040.42480HepG2RBM22
LIG3ENSG00000005156.7528.24520778.42070-0.559305.275904.37310HepG2RBM25
LIG3ENSG00000005156.7697.41540881.37320-0.337702.936002.38090HepG2NELFE
LIG3ENSG00000005156.7588.706401212.26360-1.0421017.6995016.26450HepG2RPLP0
LIG3ENSG00000005156.7379.75220558.81940-0.557304.338303.58520HepG2RPS19
LIG3ENSG00000005156.7434.29740631.69170-0.540503.017102.18270HepG2RPS3A
LIG3ENSG00000005156.7318.91470580.50060-0.864107.344706.13600HepG2RRP9
LIG3ENSG00000005156.7407.68060560.86290-0.460202.836501.88610HepG2SERBP1
LIG3ENSG00000005156.7616.419201019.81330-0.726305.462104.49620HepG2SF3A3
LIG3ENSG00000005156.7533.522501077.49820-1.0141015.0665013.56350HepG2SF3B1
LIG3ENSG00000005156.7543.83490824.51420-0.600407.721106.81110HepG2SF3B4
LIG3ENSG00000005156.7600.46060785.04550-0.386704.186903.42500HepG2SMN1
LIG3ENSG00000005156.7479.206301198.90940-1.3230014.1513012.39940HepG2SNRNP70
LIG3ENSG00000005156.7406.924601374.97470-1.7566073.6245071.94350HepG2SRFBP1
LIG3ENSG00000005156.7626.28590911.04430-0.540706.840805.91710HepG2SRSF5
LIG3ENSG00000005156.7638.012501105.61330-0.7932015.8454014.41930HepG2SRSF7
LIG3ENSG00000005156.7483.30420700.17530-0.534806.266905.49560HepG2SRSF9
LIG3ENSG00000005156.7972.945901193.76580-0.295103.258902.71300HepG2SSB
LIG3ENSG00000005156.7396.91560549.44690-0.469102.486101.45180HepG2STIP1
LIG3ENSG00000005156.7480.06070791.53340-0.721407.773806.25470HepG2SUPT6H
LIG3ENSG00000005156.7294.29700757.48570-1.3639017.4692016.02310HepG2SUPV3L1
LIG3ENSG00000005156.7693.742201061.10490-0.613106.184905.16200HepG2TARDBP
LIG3ENSG00000005156.7245.39910507.68470-1.0488010.219408.54420HepG2TFIP11
LIG3ENSG00000005156.7450.34330734.50460-0.705708.369807.58570HepG2TIAL1
LIG3ENSG00000005156.7394.33300741.10070-0.9103016.4174015.19690HepG2TRIM56
LIG3ENSG00000005156.7615.054301002.59510-0.705006.854105.87770HepG2U2AF1
LIG3ENSG00000005156.7562.914901118.34660-0.990403.045302.00810HepG2U2AF2
LIG3ENSG00000005156.7679.96610954.22470-0.488903.065402.18630HepG2UBE2L3
LIG3ENSG00000005156.7291.62160447.43490-0.617604.348303.39480HepG2UCHL5
LIG3ENSG00000005156.7571.05700904.41970-0.663409.213308.06690HepG2UPF1
LIG3ENSG00000005156.7489.16470693.48930-0.503602.876901.85280HepG2UPF2
LIG3ENSG00000005156.7729.89520929.60760-0.348903.345202.20690HepG2UTP18
LIG3ENSG00000005156.7400.30420565.79880-0.499202.509701.47250HepG2XPO5
LIG3ENSG00000005156.7500.85930745.66310-0.574104.647603.71720HepG2XRN2
LIG3ENSG00000005156.7682.867801039.65150-0.6064010.685209.50860HepG2ZC3H8
LIG3ENSG00000005156.7533.71560994.68680-0.8982021.9212020.74210HepG2ZNF622
LIG3ENSG00000005156.72171.192102573.27030-0.245102.996902.40980K562AGGF1
LIG3ENSG00000005156.72183.996902827.68160-0.372603.607702.44830K562AKAP8
LIG3ENSG00000005156.71955.298402677.61580-0.453605.089004.19180K562AKAP8L
LIG3ENSG00000005156.7955.929302006.34290-1.0696020.6138019.18610K562AQR
LIG3ENSG00000005156.7954.944401188.48990-0.315603.657502.54650K562BCLAF1
LIG3ENSG00000005156.71990.578103064.82540-0.622603.900702.59720K562CNOT7
LIG3ENSG00000005156.71828.516202217.75530-0.278403.238202.03460K562CPEB4
LIG3ENSG00000005156.7688.72160901.64700-0.388603.569802.34770K562CSTF2
LIG3ENSG00000005156.72301.749703280.28040-0.511109.284107.54470K562CELF1
LIG3ENSG00000005156.72357.194903019.15140-0.357103.151901.58530K562DDX19B
LIG3ENSG00000005156.71323.218802294.64530-0.7942023.4284021.71860K562DDX47
LIG3ENSG00000005156.72408.721902881.23470-0.258402.918002.01630K562DKC1
LIG3ENSG00000005156.7788.633401090.69860-0.467803.783702.70360K562EFTUD2
LIG3ENSG00000005156.7496.33790956.78530-0.946906.969105.32190K562EIF3A
LIG3ENSG00000005156.7714.80820900.40680-0.333003.094802.25470K562EIF3G
LIG3ENSG00000005156.71875.737102667.38250-0.5080010.640908.84660K562EIF4G2
LIG3ENSG00000005156.71131.884101618.81920-0.516203.729201.79270K562ESF1
LIG3ENSG00000005156.7952.460101331.46200-0.483303.414902.46150K562FMR1
LIG3ENSG00000005156.7767.674201128.48660-0.555804.850203.60460K562FTO
LIG3ENSG00000005156.71011.109301202.25380-0.249802.167601.62030K562FXR1
LIG3ENSG00000005156.7741.386001076.40560-0.537903.595602.76510K562G3BP2
LIG3ENSG00000005156.71352.006901734.97500-0.359804.286602.87400K562GLRX3
LIG3ENSG00000005156.7918.590601249.53230-0.443902.930302.11320K562GPKOW
LIG3ENSG00000005156.71406.971401970.53650-0.486005.929304.81970K562GRSF1
LIG3ENSG00000005156.71962.514602867.84830-0.547303.460501.68020K562HNRNPAB
LIG3ENSG00000005156.7749.869101335.86330-0.8331013.3001012.07260K562HNRNPC
LIG3ENSG00000005156.71248.418701725.43470-0.466906.743305.34330K562HNRNPU
LIG3ENSG00000005156.72041.373702841.57950-0.477205.920704.60870K562KIF1C
LIG3ENSG00000005156.71004.686701405.06730-0.483905.274204.10340K562MAGOH
LIG3ENSG00000005156.72249.894602720.12340-0.273802.236601.30320K562MAK16
LIG3ENSG00000005156.72211.995402843.07760-0.362103.599602.31190K562MSI2
LIG3ENSG00000005156.71438.724201824.11190-0.342405.063303.99530K562MTPAP
LIG3ENSG00000005156.71657.289602231.26100-0.429002.754001.87320K562NAA15
LIG3ENSG00000005156.71392.799502026.68480-0.5411015.1855013.63050K562NSUN2
LIG3ENSG00000005156.71511.922502944.39240-0.961608.562706.40180K562PABPC1
LIG3ENSG00000005156.71270.746502332.83160-0.876402.546501.60720K562PABPN1
LIG3ENSG00000005156.7754.818701250.08460-0.727809.576607.72020K562PCBP2
LIG3ENSG00000005156.71170.624101952.16690-0.737808.939207.44860K562PCBP3
LIG3ENSG00000005156.7932.927701497.39990-0.6826010.860409.31940K562POLR2G
LIG3ENSG00000005156.7659.359601061.37500-0.686807.091105.89220K562PRPF8
LIG3ENSG00000005156.71858.044102910.24560-0.6474010.851009.21920K562PUF60
LIG3ENSG00000005156.72198.162103032.95950-0.464407.757406.12340K562PUM2
LIG3ENSG00000005156.72130.568002655.37860-0.317702.320701.81430K562PUS1
LIG3ENSG00000005156.71896.596102587.33400-0.448106.885505.97790K562RBM15
LIG3ENSG00000005156.7853.703401308.77710-0.616407.267105.82290K562RBM22
LIG3ENSG00000005156.7781.619501020.63620-0.384903.325101.85340K562RBM25
LIG3ENSG00000005156.7497.074001081.13720-1.1210014.4527012.56210K562RPS19
LIG3ENSG00000005156.71747.128902733.09830-0.645604.377002.35180K562RPS3A
LIG3ENSG00000005156.7943.029001232.76810-0.386502.582101.61710K562RPS3
LIG3ENSG00000005156.7751.699101085.21970-0.529803.322701.86230K562RRP9
LIG3ENSG00000005156.71851.109602791.53120-0.592703.597201.80750K562SBDS
LIG3ENSG00000005156.71403.428401999.92080-0.511008.685107.29710K562SF3A3
LIG3ENSG00000005156.7706.790101188.18450-0.749406.624805.08420K562SF3B1
LIG3ENSG00000005156.7785.012801118.95110-0.511406.204004.88630K562SF3B4
LIG3ENSG00000005156.7790.495401036.08010-0.390303.060801.72680K562SLBP
LIG3ENSG00000005156.7789.612901338.34250-0.7612012.0862010.60480K562SRSF1
LIG3ENSG00000005156.71098.251101428.61260-0.379404.566103.04280K562SRSF7
LIG3ENSG00000005156.7675.243101027.65340-0.605905.064203.65430K562SUPV3L1
LIG3ENSG00000005156.7661.50740936.76390-0.501903.632401.69980K562TFIP11
LIG3ENSG00000005156.7834.798601152.03180-0.464703.557002.49200K562TIAL1
LIG3ENSG00000005156.7814.897901087.63810-0.416503.027101.95600K562UCHL5
LIG3ENSG00000005156.71664.005002148.94220-0.369006.109905.09010K562UPF1
LIG3ENSG00000005156.71526.878902258.55730-0.564805.539503.84950K562UTP3
LIG3ENSG00000005156.71344.276701912.17060-0.5084011.164309.59730K562WDR43
LIG3ENSG00000005156.7818.555801107.50930-0.436203.318301.95620K562XRN2
LIG3ENSG00000005156.71707.217402260.02730-0.404704.126503.03630K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for LIG3 is not available on ENCORE database.





4 RBPs can affect the splicing of LIG3 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SELIG3ENSG00000005156.7chr17+333235923332367233323082333232143332475633324844-0.328000.000000.00000excludedK562SF3B4
SELIG3ENSG00000005156.7chr17+333130063331315033310020333105713331648433316682-0.064000.011360.08981excludedK562AQR
SELIG3ENSG00000005156.7chr17+333235923332367233323064333232143332475633324844-0.149000.001280.02465excludedK562U2AF2
A3SSLIG3ENSG00000005156.7chr17+3332824733328422333282753332842233326800333268750.079000.000870.03355longerK562U2AF2
MXELIG3ENSG00000005156.7chr17+3331002033310571333130063331315033307530333076163331648433316682-0.061000.002320.039832includedK562HNRNPUL1

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for LIG3 is not avaliable on ENCORE database.