AGO1

General Information

Gene Name : AGO1
Gene ID : ENSG00000092847.11
Essential Gene : No

Functions

RNA stability & decay
microRNA processing
Translation regulation

Localization(RBPImage: AGO1)

Nuclei
Nucleoplasm
Cytoplasm
Compartment/Organelle
Mitochondria

Domains (AlphaFold: AGO1)

No checked domain (RRM, ZNF, KH, Helicase, Nuclease, dRBM or PUM_HD)

Antibody Validation

View validation images for all AGO1 antibodies

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	AGO1	ENSG00000092847.11	6.13	8.06	7.10	ENCSR000AEF
HepG2	AGO1	ENSG00000092847.11	15.48	10.91	13.20	ENCSR985KAT
K562	AGO1	ENSG00000092847.11	18.60	18.22	18.41	ENCSR000AEO

Assays

2 Released experiments are available on ENCORE database.

Assay Type	Exp_Name	ENCODE ID	Target label	Biosample	Status	Linked Antibody	Controls	Method	Note
knockdown followed by RNA-seq	AGO1-BGKLV13-K562	ENCSR268JDD	AGO1	K562	Released		ENCSR084SCN	shRNA	KD% = 64.6,81.1
knockdown followed by RNA-seq	AGO1-BGHLV14-HepG2	ENCSR533HXS	AGO1	HepG2	Released		ENCSR003EKR	shRNA	KD% = 93.1,94.1

eCLIP

No eCLIP experiment available

Antibody Validation

GeneName	Antibody_DCC_ID	Product_ID	Lot_ID	Phosphate	HepG2 Primary Validation	K562 Primary Validation	HepG2 Secondary Validation	K562 Secondary Validation
AGO1	ENCAB179WCQ	RN028PW	2			Released, ENCODE3	BGHLV14-13, Released, ENCODE3	BGKLV13-69, NotSatisfied, ENCODE3
AGO1	ENCAB189GDE	5053	1		Released, ENCODE3	Released, ENCODE3	BGHLV14-13, Released, ENCODE3

KD RNA-Seq

GeneName	Cell_Line	Method	Exp_ID	Control_ID	Sample_reps	Control_reps	KD%	Status	Project	Note
AGO1	K562	shRNA	ENCSR268JDD	ENCSR084SCN	EIF2C1_BGKLV13_69,EIF2C1_BGKLV13_70	non-target_BGKLV13_73,non-target_BGKLV13_74	64.6,81.1	Released	ENCODE3
AGO1	HepG2	shRNA	ENCSR533HXS	ENCSR003EKR	EIF2C1_BGHLV14-13,EIF2C1_BGHLV14-14	NT_BGHLV14-1_1,NT_BGHLV14-2_1	93.1,94.1	Released	ENCODE3

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

AGO1: Click to RBP Image Database

Nuclei

Nucleoplasm

Cytoplasm

Compartment/Organelle

Mitochondria

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela
AGO1	Product_ID: RN028PW Lot_ID: 2 Source: MBLI Target Name: AGO1-human
AGO1	Product_ID: 5053 Lot_ID: 1 Source: Cell Signaling Technology Target Name: AGO1-human

Summary
Proteins Bound to RBP RNA

RNA Targets

eCLIP assay for AGO1 is not avaliable on ENCORE database.

Proteins bound to RNA

AGO1 RNA is bound by 33 proteins.

eCLIP assay for AGO1 is not avaliable on ENCORE database.

33 proteins are bound to AGO1 RNA:

Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr1	36386906	36386975	+	3'-UTR	3.10017	4.07409	K562	AKAP1
chr1	36387931	36388000	+	3'-UTR	3.58618	15.96245	K562	UPF1
chr1	36388133	36388221	+	3'-UTR	3.95018	13.51561	HepG2	PTBP1
chr1	36390814	36390858	+	3'-UTR	3.20836	3.69083	K562	PTBP1
chr1	36386717	36386765	+	3'-UTR	3.07405	10.87341	K562	UPF1
chr1	36386723	36386766	+	3'-UTR	4.51584	5.07733	HepG2	PTBP1
chr1	36385294	36385375	+	3'-UTR	3.89149	3.45012	HepG2	UPF1
chr1	36385849	36385912	+	3'-UTR	3.60089	18.82402	K562	UPF1
chr1	36393254	36393367	+	3'-UTR	4.07282	4.11622	K562	HNRNPA1
chr1	36386900	36386979	+	3'-UTR	4.30742	33.54067	K562	FAM120A
chr1	36385665	36385700	+	3'-UTR	5.12619	14.54319	K562	UPF1
chr1	36387022	36387038	+	3'-UTR	4.21443	17.69871	K562	UPF1
chr1	36387273	36387303	+	3'-UTR	4.80864	9.89033	K562	UPF1
chr1	36385866	36385903	+	3'-UTR	3.14967	9.04859	K562	FAM120A
chr1	36387068	36387115	+	3'-UTR	3.38940	6.81759	K562	UPF1
chr1	36386950	36387008	+	3'-UTR	4.09138	29.97724	K562	UPF1
chr1	36386336	36386369	+	3'-UTR	3.79676	3.97268	K562	PTBP1
chr1	36386338	36386412	+	3'-UTR	3.69679	15.37451	K562	UPF1
chr1	36386979	36387005	+	3'-UTR	3.27686	5.87674	K562	FAM120A
chr1	36388157	36388239	+	3'-UTR	3.47974	9.58084	K562	FAM120A
chr1	36387148	36387178	+	3'-UTR	5.33785	9.12015	K562	UPF1
chr1	36388132	36388164	+	3'-UTR	4.53138	20.13582	K562	PTBP1
chr1	36386916	36386947	+	3'-UTR	4.30165	5.93005	K562	HNRNPC
chr1	36386900	36386916	+	3'-UTR	3.96450	4.36164	K562	HNRNPC
chr1	36388509	36388549	+	3'-UTR	4.93167	12.67045	K562	UPF1
chr1	36388260	36388317	+	3'-UTR	4.41457	5.04056	HepG2	RBFOX2
chr1	36386714	36386774	+	3'-UTR	3.23031	12.87657	K562	PTBP1
chr1	36387920	36387968	+	3'-UTR	3.78504	11.93278	K562	FAM120A
chr1	36387568	36387602	+	3'-UTR	3.29686	6.46691	K562	UPF1
chr1	36385393	36385488	+	3'-UTR	3.48623	4.21448	HepG2	UPF1
chr1	36387038	36387064	+	3'-UTR	4.35762	18.39029	K562	UPF1
chr1	36386055	36386129	+	3'-UTR	4.05429	18.92332	K562	FAM120A
chr1	36385835	36385916	+	3'-UTR	3.32684	3.95118	HepG2	PCBP2
chr1	36387219	36387253	+	3'-UTR	3.89867	8.82905	K562	UPF1
chr1	36385221	36385283	+	3'-UTR	3.09062	3.04831	K562	RBM15
chr1	36391462	36391555	+	3'-UTR	5.38506	13.22966	K562	PUM2
chr1	36388164	36388225	+	3'-UTR	3.87194	36.54398	K562	PTBP1
chr1	36387750	36387786	+	3'-UTR	3.39842	9.48463	K562	UPF1
chr1	36386054	36386113	+	3'-UTR	3.94584	11.59710	K562	UPF1
chr1	36388264	36388314	+	3'-UTR	3.54637	8.11928	K562	FAM120A
chr1	36386900	36386950	+	3'-UTR	4.53397	64.15898	K562	UPF1
chr1	36386902	36386965	+	3'-UTR	4.53969	4.93188	HepG2	UPF1
chr1	36388503	36388541	+	3'-UTR	3.23212	7.36596	K562	PTBP1
chr1	36353973	36354070	+	5'-UTR,CDS,intron-Proximal	3.56811	5.70278	K562	AQR
chr1	36348813	36348877	+	5'-UTR,intron-Distal	3.26516	3.52645	HepG2	NCBP2
chr1	36335430	36335484	+	5'-UTR	3.59980	3.73423	K562	UCHL5
chr1	36354025	36354092	+	5'-UTR,CDS,intron-Proximal	3.66518	5.15749	K562	YBX3
chr1	36349001	36349084	+	5'-UTR,CDS,intron-Distal,intron-Proximal	3.34751	5.03073	K562	FUS
chr1	36335474	36335505	+	5'-UTR,intron-Proximal	4.24865	3.87582	K562	ZNF622
chr1	36348834	36348985	+	5'-UTR,intron-Distal	3.87398	9.88902	HepG2	DDX3X
chr1	36367825	36367940	+	CDS,intron-Proximal	3.65035	8.21285	K562	ZNF622
chr1	36367730	36367809	+	CDS,intron-Proximal	3.71192	8.13013	K562	AQR
chr1	36360722	36360781	+	CDS,intron-Proximal	3.04514	3.18789	HepG2	BCLAF1
chr1	36359384	36359456	+	CDS,intron-Proximal	4.15925	7.38067	HepG2	PRPF8
chr1	36367083	36367139	+	CDS	4.10143	3.15232	HepG2	LIN28B
chr1	36367851	36367922	+	CDS	4.03705	5.20093	K562	DDX24
chr1	36367596	36367672	+	CDS,intron-Proximal	3.77141	4.13746	HepG2	PPIG
chr1	36383979	36384027	+	CDS,intron-Proximal	3.89700	5.64813	K562	DDX24
chr1	36359963	36360004	+	CDS,intron-Proximal	3.51552	7.93092	K562	DDX24
chr1	36367732	36367811	+	CDS,intron-Proximal	3.02094	4.65130	K562	PRPF8
chr1	36358688	36358853	+	CDS,intron-Proximal	3.51955	12.48866	K562	DDX24
chr1	36381089	36381143	+	CDS	3.55493	4.13746	HepG2	PPIG
chr1	36360722	36360774	+	CDS,intron-Proximal	3.81755	9.20662	K562	DDX24
chr1	36367804	36367927	+	CDS,intron-Proximal	3.75958	8.33890	K562	UCHL5
chr1	36379599	36379671	+	CDS,intron-Proximal	4.15067	5.47926	K562	AQR
chr1	36359916	36359953	+	CDS	3.51552	3.62203	K562	DDX24
chr1	36384021	36384068	+	CDS,intron-Proximal	3.74806	3.94787	K562	AQR
chr1	36367918	36368014	+	CDS,intron-Proximal	4.99873	7.70650	HepG2	PRPF8
chr1	36379439	36379470	+	CDS,intron-Proximal	4.19220	3.70678	K562	BUD13
chr1	36379464	36379560	+	CDS	3.18200	6.32494	K562	UCHL5
chr1	36367709	36367813	+	CDS,intron-Proximal	5.54541	9.24065	HepG2	AQR
chr1	36367753	36367831	+	CDS,intron-Proximal	4.67680	4.68690	HepG2	PRPF8
chr1	36360724	36360767	+	CDS	4.12712	3.49905	HepG2	PPIG
chr1	36367100	36367116	+	CDS	3.93165	4.53300	K562	LIN28B
chr1	36383210	36383299	+	CDS	4.55962	5.14565	K562	UCHL5
chr1	36360781	36360872	+	CDS,intron-Proximal	3.83762	3.87469	HepG2	BCLAF1
chr1	36358760	36358812	+	CDS	4.02390	3.20743	HepG2	PPIG
chr1	36379793	36379828	+	CDS	4.67835	7.57924	K562	YBX3
chr1	36372538	36372612	+	CDS	4.65283	9.19326	K562	ZNF622
chr1	36367116	36367150	+	CDS	4.96939	5.20653	K562	LIN28B
chr1	36383512	36383596	+	intron-Distal	4.25935	4.76505	K562	HNRNPK
chr1	36353405	36353494	+	intron-Distal	4.41707	4.47026	K562	MATR3
chr1	36353337	36353399	+	intron-Distal	4.15834	9.00412	K562	PTBP1
chr1	36377522	36377607	+	intron-Distal	3.29154	3.56409	K562	MATR3
chr1	36352421	36352479	+	intron-Distal	3.72109	9.90337	K562	TARDBP
chr1	36353392	36353500	+	intron-Distal	3.82806	7.32475	HepG2	PTBP1
chr1	36373980	36374041	+	intron-Distal	4.41204	4.24113	K562	MATR3
chr1	36349048	36349101	+	intron-Distal,intron-Proximal	4.89068	6.41528	K562	EWSR1
chr1	36348583	36348661	+	intron-Distal	3.30193	3.36616	K562	NONO
chr1	36379001	36379124	+	intron-Distal	3.10555	3.45178	K562	MATR3
chr1	36349907	36349949	+	intron-Distal	3.02960	3.25653	K562	CSTF2T
chr1	36349519	36349615	+	intron-Distal	3.29028	4.69057	K562	FUS
chr1	36349551	36349643	+	intron-Distal	3.26540	4.77325	K562	NONO
chr1	36349104	36349195	+	intron-Distal,intron-Proximal	4.05477	4.16295	K562	FUS
chr1	36352333	36352421	+	intron-Distal	4.15891	14.71224	K562	TARDBP
chr1	36349524	36349622	+	intron-Distal	3.30915	6.27172	K562	RBFOX2
chr1	36379034	36379180	+	intron-Distal	4.35608	5.75812	K562	PTBP1
chr1	36367369	36367471	+	intron-Distal,intron-Proximal	3.10060	3.26015	K562	PTBP1
chr1	36373780	36373862	+	intron-Distal	4.15486	6.11515	K562	PTBP1
chr1	36351695	36351746	+	intron-Distal	4.11635	3.20376	K562	XRN2
chr1	36349099	36349146	+	intron-Distal,intron-Proximal	3.87613	3.53896	K562	NONO
chr1	36353399	36353496	+	intron-Distal	4.37783	24.29437	K562	PTBP1
chr1	36352540	36352628	+	intron-Distal	6.44641	25.67034	K562	TARDBP
chr1	36339162	36339302	+	intron-Distal	3.59877	3.98203	K562	MATR3
chr1	36349401	36349470	+	intron-Distal	4.43447	10.48177	HepG2	RBFOX2
chr1	36349280	36349330	+	intron-Distal	3.23087	3.84340	K562	CSTF2T
chr1	36349525	36349642	+	intron-Distal	4.38398	9.54933	HepG2	RBFOX2
chr1	36352560	36352618	+	intron-Distal	4.69198	4.19739	K562	EIF4G2
chr1	36377413	36377517	+	intron-Distal	4.35430	4.75674	K562	MATR3
chr1	36358879	36358936	+	intron-Proximal	4.30045	9.80019	K562	AQR
chr1	36381150	36381192	+	intron-Proximal	4.24548	4.49024	K562	AQR
chr1	36383328	36383399	+	intron-Proximal	5.28459	7.28294	K562	AQR
chr1	36367008	36367060	+	intron-Proximal	3.48979	4.94908	K562	TIA1
chr1	36359805	36359868	+	intron-Proximal	4.78052	3.65355	K562	EFTUD2
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

eCLIP assay for AGO1 is not avaliable on ENCORE database.

Diffrential Expression

2,355 differentially expressed genes after Knockdown/Knockout AGO1 protein.

80 RBPs can affect the levels of AGO1.

2,355 differentially expressed genes after Knockdown/Knockout AGO1 protein :

Only display 100 entries as example. Please click "View All" button to see all 2,355 entries.

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
TSPAN6	ENSG00000000003.10	2242.38360	1710.12030	0.39080	2.44120	1.40620	HepG2	AGO1
C1orf112	ENSG00000000460.12	194.99630	318.72540	-0.70890	3.75100	2.45000	HepG2	AGO1
LAS1L	ENSG00000001497.12	449.67720	644.50170	-0.51930	2.99850	1.83740	HepG2	AGO1
SEMA3F	ENSG00000001617.7	192.46090	296.83960	-0.62510	2.86080	1.73380	HepG2	AGO1
ANKIB1	ENSG00000001629.5	1242.21880	896.59970	0.47030	2.52330	1.47070	HepG2	AGO1
CYP51A1	ENSG00000001630.11	4435.80650	2768.46500	0.68000	4.13100	2.76390	HepG2	AGO1
ALS2	ENSG00000003393.10	1284.31860	958.34280	0.42230	2.56990	1.50860	HepG2	AGO1
CASP10	ENSG00000003400.10	777.14560	565.70660	0.45800	2.59120	1.52500	HepG2	AGO1
TFPI	ENSG00000003436.10	15325.28570	6935.60470	1.14370	18.83290	16.23280	HepG2	AGO1
ARF5	ENSG00000004059.6	436.30440	644.89750	-0.56370	2.72900	1.63160	HepG2	AGO1
FKBP4	ENSG00000004478.5	985.01200	1349.49330	-0.45420	2.94580	1.79700	HepG2	AGO1
KDM1A	ENSG00000004487.11	2051.89460	2712.11080	-0.40250	2.68200	1.59470	HepG2	AGO1
ARHGAP33	ENSG00000004777.14	55.98500	161.19530	-1.52570	7.06610	5.33090	HepG2	AGO1
HCCS	ENSG00000004961.10	123.04190	269.67170	-1.13210	7.31900	5.55310	HepG2	AGO1
DVL2	ENSG00000004975.7	310.55290	595.76320	-0.93990	7.79020	5.97930	HepG2	AGO1
SKAP2	ENSG00000005020.8	603.52020	394.75560	0.61230	3.05160	1.88130	HepG2	AGO1
DHX33	ENSG00000005100.8	774.04550	1079.96040	-0.48050	3.03350	1.86750	HepG2	AGO1
LIG3	ENSG00000005156.7	392.52850	563.03750	-0.52040	2.87060	1.74150	HepG2	AGO1
ACSM3	ENSG00000005187.7	1057.55710	786.93030	0.42630	2.39450	1.36840	HepG2	AGO1
AC004381.6	ENSG00000005189.15	134.08780	211.38190	-0.65670	2.68620	1.59750	HepG2	AGO1
ABCB4	ENSG00000005471.11	1007.34660	678.54970	0.56990	3.97520	2.63440	HepG2	AGO1
SOX8	ENSG00000005513.9	32.66010	7.72230	2.08030	3.43290	2.19020	HepG2	AGO1
IBTK	ENSG00000005700.10	2612.24680	1889.59070	0.46710	3.38480	2.15050	HepG2	AGO1
ZNF195	ENSG00000005801.12	491.91560	336.01940	0.54980	2.42700	1.39520	HepG2	AGO1
PDK2	ENSG00000005882.7	239.10200	375.91980	-0.65280	3.03780	1.87060	HepG2	AGO1
ITGA3	ENSG00000005884.13	192.27840	53.91000	1.83450	12.25500	10.10620	HepG2	AGO1
LAMP2	ENSG00000005893.11	4858.62630	3416.08020	0.50810	4.08230	2.72300	HepG2	AGO1
GDE1	ENSG00000006007.7	2097.25950	1323.43020	0.66410	5.94310	4.32770	HepG2	AGO1
CRLF1	ENSG00000006016.6	1304.19840	2713.07600	-1.05680	2.58400	1.51880	HepG2	AGO1
TNFRSF12A	ENSG00000006327.9	527.38070	369.05280	0.51490	2.74780	1.64570	HepG2	AGO1
JHDM1D	ENSG00000006459.6	2335.17020	1573.87970	0.56910	3.25580	2.04540	HepG2	AGO1
ALDH3B1	ENSG00000006534.11	73.19640	128.06830	-0.80710	2.62130	1.54730	HepG2	AGO1
IFRD1	ENSG00000006652.9	719.33720	430.54430	0.74040	5.49400	3.94000	HepG2	AGO1
PROM1	ENSG00000007062.7	779.12600	527.37250	0.56290	3.54230	2.27980	HepG2	AGO1
E2F2	ENSG00000007968.6	50.08870	195.35960	-1.96360	12.06700	9.93640	HepG2	AGO1
NADK	ENSG00000008130.11	619.23890	846.88210	-0.45170	2.61280	1.54190	HepG2	AGO1
SYPL1	ENSG00000008282.3	1382.13340	1013.84510	0.44700	2.81440	1.69930	HepG2	AGO1
MPND	ENSG00000008382.11	73.40490	144.74910	-0.97960	2.65640	1.57450	HepG2	AGO1
NFIX	ENSG00000008441.12	202.86420	315.88190	-0.63890	2.92380	1.78130	HepG2	AGO1
IL32	ENSG00000008517.12	2085.06830	1580.86300	0.39930	2.52530	1.47150	HepG2	AGO1
MED24	ENSG00000008838.13	977.11060	1506.42910	-0.62450	2.48580	1.44320	HepG2	AGO1
HEATR5B	ENSG00000008869.7	873.83190	645.86160	0.43600	2.46610	1.42680	HepG2	AGO1
SEC62	ENSG00000008952.12	2800.82610	2081.27200	0.42830	2.93380	1.78850	HepG2	AGO1
UQCRC1	ENSG00000010256.6	1924.16530	2657.05900	-0.46560	3.36220	2.13190	HepG2	AGO1
NCAPD2	ENSG00000010292.8	1432.52680	2932.12850	-1.03340	14.09040	11.83060	HepG2	AGO1
GIPR	ENSG00000010310.4	133.13260	53.96810	1.30260	5.51140	3.95260	HepG2	AGO1
IDS	ENSG00000010404.13	1183.32530	633.01290	0.90240	9.10530	7.18420	HepG2	AGO1
CD4	ENSG00000010610.5	186.13890	112.62360	0.72480	2.81550	1.69970	HepG2	AGO1
HIVEP2	ENSG00000010818.4	1532.93780	972.23820	0.65680	5.66880	4.09130	HepG2	AGO1
PTBP1	ENSG00000011304.12	2108.23790	3309.30960	-0.65050	3.80090	2.49190	HepG2	AGO1
SYT7	ENSG00000011347.5	336.47440	220.64050	0.60870	2.40940	1.38070	HepG2	AGO1
LARS2	ENSG00000011376.5	489.11940	759.35550	-0.63460	4.41830	3.00510	HepG2	AGO1
ANLN	ENSG00000011426.6	865.60780	1866.29590	-1.10840	5.89440	4.28820	HepG2	AGO1
PPP5C	ENSG00000011485.10	552.52060	823.54080	-0.57580	3.81100	2.50050	HepG2	AGO1
MAP4K3	ENSG00000011566.10	2484.36800	1784.41190	0.47730	3.32710	2.10310	HepG2	AGO1
BRCA1	ENSG00000012048.15	381.22180	784.82390	-1.04170	5.91830	4.30910	HepG2	AGO1
EXTL3	ENSG00000012232.4	423.34760	598.53350	-0.49960	2.74670	1.64510	HepG2	AGO1
ELOVL5	ENSG00000012660.9	3050.65170	1954.73250	0.64200	4.57120	3.13860	HepG2	AGO1
UBR7	ENSG00000012963.9	389.59330	551.68740	-0.50190	2.72420	1.62800	HepG2	AGO1
SLC25A39	ENSG00000013306.11	970.28500	1503.96440	-0.63230	2.95890	1.80770	HepG2	AGO1
DDX11	ENSG00000013573.12	378.81700	582.23350	-0.62010	3.91850	2.58830	HepG2	AGO1
TACC3	ENSG00000013810.14	220.10160	745.19760	-1.75950	25.02870	22.02680	HepG2	AGO1
POLA2	ENSG00000014138.4	123.91890	282.24280	-1.18750	7.95830	6.13880	HepG2	AGO1
MTMR11	ENSG00000014914.15	157.56890	66.95560	1.23460	5.76880	4.17980	HepG2	AGO1
NUDCD3	ENSG00000015676.13	543.06370	748.62080	-0.46310	2.60620	1.53640	HepG2	AGO1
CYP24A1	ENSG00000019186.5	979.37570	261.10160	1.90720	31.26150	27.97710	HepG2	AGO1
RUNX3	ENSG00000020633.14	45.06930	13.34570	1.75570	3.52500	2.26480	HepG2	AGO1
PLEKHB1	ENSG00000021300.9	1987.70470	1457.81030	0.44720	2.99070	1.83260	HepG2	AGO1
GCLM	ENSG00000023909.5	432.83880	268.36990	0.68950	4.00320	2.65580	HepG2	AGO1
DEPDC1	ENSG00000024526.12	138.83760	360.43010	-1.37630	11.64070	9.53480	HepG2	AGO1
NCAPH2	ENSG00000025770.14	200.64990	353.40370	-0.81660	3.97120	2.63170	HepG2	AGO1
HMGB3	ENSG00000029993.10	459.09020	744.28210	-0.69710	3.67670	2.39040	HepG2	AGO1
SARS	ENSG00000031698.8	1977.21470	1203.18740	0.71650	6.71160	5.01070	HepG2	AGO1
RANBP3	ENSG00000031823.10	660.19210	960.83760	-0.54140	3.60330	2.32860	HepG2	AGO1
ABCF2	ENSG00000033050.3	454.71380	654.18970	-0.52480	3.14130	1.95300	HepG2	AGO1
GAB2	ENSG00000033327.8	497.10870	333.04470	0.57770	3.21660	2.01430	HepG2	AGO1
UHRF1	ENSG00000034063.9	298.61250	875.62190	-1.55200	21.39240	18.61980	HepG2	AGO1
TMSB10	ENSG00000034510.4	5568.05100	3795.32210	0.55290	4.75140	3.29590	HepG2	AGO1
RNF19A	ENSG00000034677.7	1767.63620	1239.04930	0.51250	3.54610	2.28190	HepG2	AGO1
DEPDC1B	ENSG00000035499.8	381.96860	600.44100	-0.65260	3.48350	2.23220	HepG2	AGO1
TIMP2	ENSG00000035862.8	1644.60430	1071.41830	0.61810	4.99510	3.50420	HepG2	AGO1
NSUN2	ENSG00000037474.10	902.05480	1238.95360	-0.45780	2.93460	1.78900	HepG2	AGO1
RAI14	ENSG00000039560.9	1048.91570	656.75760	0.67540	3.72010	2.42540	HepG2	AGO1
PHLPP2	ENSG00000040199.14	722.62820	444.04390	0.70250	4.89230	3.41580	HepG2	AGO1
SPDL1	ENSG00000040275.12	172.15780	393.75400	-1.19360	9.79240	7.81970	HepG2	AGO1
TDP1	ENSG00000042088.9	279.40360	438.25910	-0.64940	3.48030	2.23000	HepG2	AGO1
AIFM2	ENSG00000042286.10	406.00600	634.93000	-0.64510	4.22100	2.83880	HepG2	AGO1
DSG2	ENSG00000046604.8	4877.21730	3693.03530	0.40120	2.74160	1.64140	HepG2	AGO1
OFD1	ENSG00000046651.10	650.00520	421.96670	0.62320	3.97140	2.63170	HepG2	AGO1
WWC3	ENSG00000047644.13	158.86280	94.87560	0.74360	2.66690	1.58340	HepG2	AGO1
GOPC	ENSG00000047932.9	1806.07160	1350.29800	0.41950	2.67760	1.59120	HepG2	AGO1
RCN1	ENSG00000049449.4	1601.02780	968.98930	0.72430	6.64850	4.95790	HepG2	AGO1
RFC2	ENSG00000049541.6	186.06060	403.94860	-1.11840	8.78800	6.89420	HepG2	AGO1
DKK3	ENSG00000050165.13	21.75310	2.59600	3.06680	3.50950	2.25320	HepG2	AGO1
LETMD1	ENSG00000050426.11	506.94690	700.90440	-0.46740	2.57080	1.50930	HepG2	AGO1
LAMC3	ENSG00000050555.13	49.88020	9.02410	2.46650	6.14450	4.50350	HepG2	AGO1
MAPK9	ENSG00000050748.13	558.52080	823.81630	-0.56070	3.72910	2.43300	HepG2	AGO1
HERPUD1	ENSG00000051108.10	1892.12940	1145.04400	0.72450	6.84220	5.12700	HepG2	AGO1
RAD51	ENSG00000051180.12	126.24620	226.66520	-0.84430	3.88340	2.55800	HepG2	AGO1
POLQ	ENSG00000051341.9	183.29910	480.49090	-1.39030	13.78240	11.53940	HepG2	AGO1
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

80 RBPs can affect the gene expression of AGO1 :

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
AGO1	ENSG00000092847.6	1190.61270	1558.16530	-0.38810	5.58070	4.52540	HepG2	AKAP8L
AGO1	ENSG00000092847.6	1864.65480	2241.74660	-0.26570	3.40890	2.66170	HepG2	AUH
AGO1	ENSG00000092847.6	986.81460	1544.82070	-0.64660	8.15270	7.19020	HepG2	BOP1
AGO1	ENSG00000092847.6	1172.36480	1437.86860	-0.29450	2.64910	1.89400	HepG2	CALR
AGO1	ENSG00000092847.6	1257.74300	1550.54130	-0.30190	4.29530	3.50100	HepG2	CKAP4
AGO1	ENSG00000092847.6	896.67780	1418.22580	-0.66140	7.64320	6.54630	HepG2	CPSF6
AGO1	ENSG00000092847.6	1112.43830	1529.62800	-0.45950	5.08400	3.61110	HepG2	CPSF7
AGO1	ENSG00000092847.6	934.32660	1211.50820	-0.37480	4.10840	2.86390	HepG2	YBX3
AGO1	ENSG00000092847.6	1493.14180	1746.00650	-0.22570	2.54290	1.82710	HepG2	DAZAP1
AGO1	ENSG00000092847.6	1525.23370	1190.84970	0.35690	3.38740	2.37030	HepG2	DDX24
AGO1	ENSG00000092847.6	1038.90930	1515.56840	-0.54480	4.32080	3.56350	HepG2	DDX6
AGO1	ENSG00000092847.6	758.05580	1189.53570	-0.65000	10.65890	9.35420	HepG2	DNAJC21
AGO1	ENSG00000092847.6	956.46230	1179.14010	-0.30200	3.75160	3.01400	HepG2	DNAJC2
AGO1	ENSG00000092847.6	729.19600	966.18670	-0.40600	2.84500	1.72250	HepG2	EFTUD2
AGO1	ENSG00000092847.6	413.03970	1120.59780	-1.43990	20.47380	17.75370	HepG2	AGO1
AGO1	ENSG00000092847.6	990.49170	1457.09700	-0.55690	5.05320	4.26490	HepG2	EIF2S1
AGO1	ENSG00000092847.6	1109.07400	1610.33320	-0.53800	4.31170	3.51730	HepG2	EIF4A3
AGO1	ENSG00000092847.6	1110.28760	1567.75220	-0.49780	3.09440	2.37030	HepG2	EIF4B
AGO1	ENSG00000092847.6	1115.91400	1515.48550	-0.44160	4.74330	3.65460	HepG2	EWSR1
AGO1	ENSG00000092847.6	672.91870	840.85870	-0.32140	2.39630	1.31130	HepG2	FAM120A
AGO1	ENSG00000092847.6	1457.07890	1159.64850	0.32930	2.74650	1.60640	HepG2	FASTKD2
AGO1	ENSG00000092847.6	2073.12550	1599.85290	0.37380	2.97410	2.05020	HepG2	G3BP2
AGO1	ENSG00000092847.6	702.15230	1335.85190	-0.92790	14.65160	13.18070	HepG2	HNRNPC
AGO1	ENSG00000092847.6	1851.27570	1525.83330	0.27880	1.97030	1.37390	HepG2	HNRNPK
AGO1	ENSG00000092847.6	1331.21900	1590.40730	-0.25660	3.00830	2.30870	HepG2	HNRNPL
AGO1	ENSG00000092847.6	693.09700	1534.21950	-1.14640	19.63220	18.18770	HepG2	HNRNPLL
AGO1	ENSG00000092847.6	849.64470	1327.01740	-0.64330	12.93280	11.70040	HepG2	HNRNPU
AGO1	ENSG00000092847.6	1088.21050	1355.49810	-0.31690	4.29170	3.39820	HepG2	ILF2
AGO1	ENSG00000092847.6	972.28860	1233.27780	-0.34300	2.55980	1.46880	HepG2	LARP7
AGO1	ENSG00000092847.6	1182.14120	1517.93180	-0.36070	3.29650	2.41700	HepG2	MSI2
AGO1	ENSG00000092847.6	1170.21390	1731.34900	-0.56510	8.65760	7.33320	HepG2	NOL12
AGO1	ENSG00000092847.6	1121.07240	1489.83660	-0.41030	3.00250	2.25220	HepG2	PABPC4
AGO1	ENSG00000092847.6	817.70460	1313.47490	-0.68370	13.52050	11.88660	HepG2	PARN
AGO1	ENSG00000092847.6	1168.72750	1502.99810	-0.36290	4.93560	4.16150	HepG2	PCBP1
AGO1	ENSG00000092847.6	1002.33730	1183.58720	-0.23980	1.96950	1.33860	HepG2	PPIL4
AGO1	ENSG00000092847.6	1264.89020	1652.78900	-0.38590	3.47440	2.81660	HepG2	PUF60
AGO1	ENSG00000092847.6	983.80590	1753.25560	-0.83360	16.43600	14.88320	HepG2	PUM2
AGO1	ENSG00000092847.6	756.36770	1449.05170	-0.93790	6.79770	5.71810	HepG2	RAVER1
AGO1	ENSG00000092847.6	1756.07750	2151.23900	-0.29280	3.21150	2.66410	HepG2	RBM22
AGO1	ENSG00000092847.6	1166.98570	1503.22470	-0.36530	3.42020	2.67670	HepG2	RBM25
AGO1	ENSG00000092847.6	2075.37170	1702.03160	0.28600	3.54740	2.95100	HepG2	NELFE
AGO1	ENSG00000092847.6	903.64270	1181.74640	-0.38710	5.27950	4.44220	HepG2	SAFB2
AGO1	ENSG00000092847.6	1459.54470	1965.80480	-0.42960	3.01740	2.31230	HepG2	SF3A3
AGO1	ENSG00000092847.6	1043.43360	1518.56820	-0.54140	5.88450	4.88840	HepG2	SF3B1
AGO1	ENSG00000092847.6	1254.95410	1689.67550	-0.42910	2.19320	1.50160	HepG2	SNRNP70
AGO1	ENSG00000092847.6	1503.58880	2429.74680	-0.69240	20.84240	19.80160	HepG2	SRFBP1
AGO1	ENSG00000092847.6	2227.57130	1661.97160	0.42250	7.83890	7.13740	HepG2	SRSF1
AGO1	ENSG00000092847.6	1327.67460	1525.57010	-0.20040	1.92660	1.33480	HepG2	SRSF7
AGO1	ENSG00000092847.6	1159.60270	1352.11210	-0.22160	2.11750	1.62160	HepG2	SRSF9
AGO1	ENSG00000092847.6	851.60850	1266.44490	-0.57250	7.20530	5.74020	HepG2	SUPT6H
AGO1	ENSG00000092847.6	850.03270	1210.62800	-0.51020	3.90340	3.12150	HepG2	SUPV3L1
AGO1	ENSG00000092847.6	2018.97540	1493.87610	0.43450	6.41340	5.62060	HepG2	TAF15
AGO1	ENSG00000092847.6	1227.28580	1495.41680	-0.28510	1.97120	1.34650	HepG2	TARDBP
AGO1	ENSG00000092847.6	608.98770	811.42630	-0.41400	2.81440	1.81010	HepG2	TFIP11
AGO1	ENSG00000092847.6	949.68820	1289.31020	-0.44110	4.92280	4.29510	HepG2	TIAL1
AGO1	ENSG00000092847.6	848.92270	1300.98070	-0.61590	11.83830	10.78960	HepG2	TRIM56
AGO1	ENSG00000092847.6	1440.15350	1743.36890	-0.27570	3.51220	2.74010	HepG2	UPF1
AGO1	ENSG00000092847.6	1173.77250	1917.37120	-0.70800	22.81640	21.62300	HepG2	ZNF622
AGO1	ENSG00000092847.6	3123.23030	3513.87960	-0.17000	1.97970	1.48410	K562	AGGF1
AGO1	ENSG00000092847.6	2981.41120	3656.31660	-0.29440	2.70400	2.05800	K562	AKAP8L
AGO1	ENSG00000092847.6	3382.18150	4639.90890	-0.45610	5.90440	5.10320	K562	AQR
AGO1	ENSG00000092847.6	2081.45050	2564.15170	-0.30090	2.27090	1.48680	K562	BOP1
AGO1	ENSG00000092847.6	1767.87550	2726.39110	-0.62500	11.06040	9.47640	K562	CPSF6
AGO1	ENSG00000092847.6	3111.32640	3673.42600	-0.23960	3.16720	1.86460	K562	DDX21
AGO1	ENSG00000092847.6	1263.55670	2490.20370	-0.97880	9.16820	5.28030	K562	AGO1
AGO1	ENSG00000092847.6	3384.89480	3968.65980	-0.22950	2.73670	2.02110	K562	EIF2S2
AGO1	ENSG00000092847.6	3089.48070	4097.53290	-0.40740	4.50760	3.40600	K562	FIP1L1
AGO1	ENSG00000092847.6	3837.85320	2800.66300	0.45440	9.16090	8.13290	K562	FXR1
AGO1	ENSG00000092847.6	2049.22490	2603.00230	-0.34510	3.31680	2.44940	K562	GPKOW
AGO1	ENSG00000092847.6	3814.16580	5288.84340	-0.47160	6.80330	5.60860	K562	GRSF1
AGO1	ENSG00000092847.6	1595.10590	2295.11470	-0.52490	7.18040	6.26290	K562	HNRNPC
AGO1	ENSG00000092847.6	4440.78360	3342.98820	0.40960	3.82140	2.34490	K562	HNRNPK
AGO1	ENSG00000092847.6	2896.61760	3773.46190	-0.38150	6.08710	4.75080	K562	HNRNPU
AGO1	ENSG00000092847.6	3896.05240	5555.34590	-0.51190	6.80290	5.56420	K562	HSPD1
AGO1	ENSG00000092847.6	3095.33850	3714.38680	-0.26300	2.57900	1.55450	K562	MAK16
AGO1	ENSG00000092847.6	2965.63700	4103.07030	-0.46840	4.53920	3.47600	K562	PCBP3
AGO1	ENSG00000092847.6	2431.00560	3147.22480	-0.37250	4.67840	3.63640	K562	POLR2G
AGO1	ENSG00000092847.6	3233.51990	4651.55020	-0.52460	6.63400	5.26660	K562	PPIG
AGO1	ENSG00000092847.6	2474.55540	3017.78000	-0.28630	2.15500	1.48970	K562	PRPF8
AGO1	ENSG00000092847.6	4236.33380	3418.01490	0.30960	3.41520	2.68580	K562	PTBP1
AGO1	ENSG00000092847.6	5008.38280	6563.27290	-0.39010	6.01590	4.58330	K562	PUM2
AGO1	ENSG00000092847.6	2893.28770	3533.08780	-0.28820	3.65980	2.99150	K562	RBM15
AGO1	ENSG00000092847.6	3374.20420	2804.15920	0.26690	2.38480	1.38360	K562	SAFB
AGO1	ENSG00000092847.6	3461.25980	2725.57630	0.34460	4.43470	3.34190	K562	SF3B4
AGO1	ENSG00000092847.6	4321.96800	3350.89810	0.36700	4.67660	3.76190	K562	SRSF1
AGO1	ENSG00000092847.6	3702.18730	3156.70710	0.22990	2.25370	1.51150	K562	SYNCRIP
AGO1	ENSG00000092847.6	2713.57630	2102.75600	0.36780	3.46620	2.38640	K562	TRIM56
AGO1	ENSG00000092847.6	3318.04310	2541.01270	0.38480	3.00060	1.85230	K562	U2AF1
AGO1	ENSG00000092847.6	3234.03650	2623.87690	0.30150	3.44270	2.54890	K562	U2AF2
AGO1	ENSG00000092847.6	3501.25450	4379.53770	-0.32290	6.59980	5.54450	K562	UPF1
AGO1	ENSG00000092847.6	3698.22220	5226.95930	-0.49910	6.94950	5.48250	K562	ZC3H8
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

The Knockdown/knockout RNA-Seq assay for AGO1 is not available on ENCORE database.

4 RBPs can affect the splicing of AGO1 :

Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	2ndExonStart	2ndExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	p-value	FDR	is_included	Cell Line	Affected by RBP
SE	AGO1	ENSG00000092847.6	chr1	+	36358157	36358278			36354027	36354211	36358697	36358879	-0.31800	0.00064	0.01455	excluded	K562	SF3B4
A3SS	AGO1	ENSG00000092847.6	chr1	+	36384607	36384855			36384655	36384855	36383922	36384024	0.07400	0.00079	0.02182	longer	HepG2	U2AF2
A3SS	AGO1	ENSG00000092847.6	chr1	+	36359888	36360003			36359915	36360003	36359597	36359772	0.08800	0.00153	0.01013	longer	K562	AQR
A3SS	AGO1	ENSG00000092847.6	chr1	+	36384624	36384855			36384655	36384855	36383922	36384024	0.05700	0.01757	0.08540	longer	K562	AQR
A3SS	AGO1	ENSG00000092847.6	chr1	+	36358111	36358278			36358157	36358278	36354027	36354211	0.10300	0.00050	0.00372	longer	K562	AQR
MXE	AGO1	ENSG00000092847.6	chr1	+	36367804	36367938	36372620	36372720	36367548	36367671	36379442	36379602	0.20100	0.00001	0.00115	1included	K562	DHX30

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

AGO1

General Information

Functions

Localization(RBPImage: AGO1)

Domains (AlphaFold: AGO1)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

eCLIP assay for AGO1 is not avaliable on ENCORE database.

33 proteins are bound to AGO1 RNA:

eCLIP assay for AGO1 is not avaliable on ENCORE database.

Diffrential Expression

2,355 differentially expressed genes after Knockdown/Knockout AGO1 protein :

80 RBPs can affect the gene expression of AGO1 :

The Knockdown/knockout RNA-Seq assay for AGO1 is not available on ENCORE database.

4 RBPs can affect the splicing of AGO1 :

The Knockdown/knockout RNA-Seq assay for AGO1 is not avaliable on ENCORE database.