POLQ

General Information

Gene Name       : POLQ
Gene ID             : ENSG00000051341.13
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: POLQ)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878POLQENSG00000051341.1312.2111.7311.97ENCSR000AEF
HepG2POLQENSG00000051341.137.9811.509.74ENCSR985KAT
K562POLQENSG00000051341.134.815.425.12ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for POLQ is not avaliable on ENCORE database.



Proteins bound to RNA
  • POLQ RNA is bound by 14 proteins.  







eCLIP assay for POLQ is not avaliable on ENCORE database.





14 proteins are bound to POLQ RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr3121264730121264838-5'-UTR,intron-Distal3.263876.83419HepG2NCBP2
chr3121151681121151812-CDS,intron-Distal,intron-Proximal3.731776.35344K562PRPF8
chr3121202236121202275-CDS,intron-Distal3.381363.27569HepG2BCLAF1
chr3121217342121217443-CDS,intron-Distal4.758645.56813HepG2PPIG
chr3121258289121258319-CDS,intron-Distal4.198863.06595HepG2BCLAF1
chr3121206521121206640-CDS,intron-Distal3.504533.34920HepG2HLTF
chr3121228890121228973-CDS,intron-Distal4.063203.56019HepG2GRWD1
chr3121240849121240860-CDS,intron-Distal,intron-Proximal4.054103.38968HepG2BCLAF1
chr3121228882121228988-CDS,intron-Distal,intron-Proximal3.149056.89364HepG2PPIG
chr3121200418121200454-CDS,intron-Distal,intron-Proximal4.354964.67689HepG2PPIG
chr3121212438121212496-CDS,intron-Distal3.231424.99842HepG2PPIG
chr3121255980121256047-CDS,intron-Distal3.676665.97823HepG2BCLAF1
chr3121255944121256045-CDS,intron-Distal,intron-Proximal3.127125.47500HepG2PPIG
chr3121212393121212533-CDS,intron-Distal3.289713.89474HepG2GRWD1
chr3121195530121195581-CDS,intron-Distal,intron-Proximal3.705184.52024HepG2PPIG
chr3121212395121212507-CDS,intron-Distal4.326267.97334HepG2BCLAF1
chr3121215654121215679-CDS,intron-Distal,intron-Proximal4.136093.06595HepG2BCLAF1
chr3121209209121209269-CDS,intron-Distal,intron-Proximal3.308203.17814K562U2AF1
chr3121251839121251872-CDS,intron-Distal4.372824.04372HepG2BCLAF1
chr3121238897121238928-CDS,intron-Distal4.215073.45943HepG2BCLAF1
chr3121228890121228978-CDS,intron-Distal3.644656.39464HepG2BCLAF1
chr3121209210121209272-CDS,intron-Distal,intron-Proximal3.415024.46214K562U2AF2
chr3121240955121240999-CDS,intron-Distal,intron-Proximal4.754074.37348HepG2BCLAF1
chr3121258048121258095-intron-Distal3.564554.52210K562KHSRP
chr3121234181121234256-intron-Distal4.301124.31871HepG2HNRNPM
chr3121231688121231880-intron-Distal3.984327.77021K562KHSRP
chr3121205676121205771-intron-Distal4.4630510.83785K562PTBP1
chr3121185916121186043-intron-Distal3.317083.27944K562PTBP1
chr3121258095121258118-intron-Distal4.827807.58902K562KHSRP
chr3121158418121158501-intron-Distal4.333803.80778HepG2QKI
chr3121211686121211807-intron-Distal4.872845.37186HepG2ILF3
chr3121185871121185960-intron-Distal3.912613.28841HepG2PTBP1
chr3121234187121234273-intron-Distal4.568324.27460K562HNRNPM
chr3121205670121205771-intron-Distal3.764595.07626HepG2PTBP1
chr3121258118121258165-intron-Distal4.428625.68841K562KHSRP
chr3121223390121223473-intron-Distal3.801915.38829K562KHSRP
chr3121258165121258240-intron-Distal,intron-Proximal4.499786.27552K562KHSRP
chr3121195262121195328-intron-Distal,intron-Proximal4.389615.08344K562TARDBP
chr3121223249121223359-intron-Distal4.525555.44709K562KHSRP
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for POLQ is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for POLQ is not available on ENCORE database.

  • 141 RBPs can affect the levels of POLQ.  








The Knockdown/knockout RNA-Seq assay for POLQ is not available on ENCORE database.





141 RBPs can affect the gene expression of POLQ :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
POLQENSG00000051341.9425.18150633.04250-0.574206.841605.97190HepG2ACO1
POLQENSG00000051341.9647.99480449.629000.527103.865802.71050HepG2ADAR
POLQENSG00000051341.9118.69100268.25030-1.176406.886806.08920HepG2AKAP1
POLQENSG00000051341.970.48400148.20140-1.072203.330902.19470HepG2AKAP8
POLQENSG00000051341.9444.92220636.06060-0.515605.375204.34000HepG2AKAP8L
POLQENSG00000051341.948.28310221.95640-2.2007017.7459015.95780HepG2ASCC1
POLQENSG00000051341.9321.22670784.45910-1.2881027.6784025.90760HepG2AUH
POLQENSG00000051341.9370.09570589.79240-0.672304.415803.23040HepG2BCCIP
POLQENSG00000051341.9302.31520512.47710-0.761404.835703.67660HepG2BCLAF1
POLQENSG00000051341.941.91440728.46510-4.11930100.3638098.01260HepG2BOP1
POLQENSG00000051341.9260.00500714.13920-1.4577026.2033024.31640HepG2CALR
POLQENSG00000051341.9123.41040210.87330-0.772903.456302.59820HepG2CIRBP
POLQENSG00000051341.9171.54930632.95770-1.8835049.1773047.19000HepG2CKAP4
POLQENSG00000051341.936.71060127.41110-1.795207.745806.47530HepG2CNOT7
POLQENSG00000051341.9439.35080668.76850-0.606104.707303.83180HepG2CPSF6
POLQENSG00000051341.9367.61060735.97480-1.0015017.4586016.12070HepG2CELF1
POLQENSG00000051341.9473.20700791.48050-0.7421013.5633012.13060HepG2DAZAP1
POLQENSG00000051341.9351.46960521.89950-0.570404.262903.43880HepG2DDX21
POLQENSG00000051341.9348.22580510.59790-0.552204.273703.12840HepG2DDX24
POLQENSG00000051341.981.73450256.96730-1.6526012.9953011.73360HepG2DDX3X
POLQENSG00000051341.9224.76500579.89180-1.3674014.6622013.07000HepG2DDX55
POLQENSG00000051341.9340.78300759.43650-1.156108.541006.88240HepG2DDX59
POLQENSG00000051341.945.07490220.73130-2.2919017.1059015.74300HepG2DDX6
POLQENSG00000051341.9442.47490605.66380-0.452904.005103.21970HepG2DKC1
POLQENSG00000051341.9302.92520452.77890-0.579804.899503.98760HepG2DNAJC21
POLQENSG00000051341.9301.50820448.72510-0.573605.681304.79440HepG2DNAJC2
POLQENSG00000051341.9270.52780396.89630-0.553003.166401.98130HepG2EFTUD2
POLQENSG00000051341.9183.29910480.49090-1.3903013.7824011.53940HepG2AGO1
POLQENSG00000051341.929.40350212.20320-2.8514023.2940021.68330HepG2EIF2S1
POLQENSG00000051341.9199.68460386.47610-0.952706.906605.53290HepG2EIF3D
POLQENSG00000051341.9526.94950780.73480-0.567203.341302.43690HepG2EIF4G1
POLQENSG00000051341.9553.41640900.62890-0.7026010.201109.16600HepG2ETF1
POLQENSG00000051341.9249.08050345.39150-0.471602.738801.57800HepG2FAM120A
POLQENSG00000051341.9280.83070497.28820-0.824407.887306.14490HepG2FASTKD2
POLQENSG00000051341.9532.09590737.70270-0.471402.505201.76910HepG2FIP1L1
POLQENSG00000051341.9363.25680669.91930-0.883003.656302.48310HepG2FTO
POLQENSG00000051341.9250.09270141.634000.820204.766803.75060HepG2FUBP3
POLQENSG00000051341.9384.28030236.601600.699604.224003.38240HepG2FXR1
POLQENSG00000051341.9421.96460233.007400.856606.429605.06360HepG2G3BP2
POLQENSG00000051341.9432.62240758.09530-0.809307.218206.21550HepG2GPKOW
POLQENSG00000051341.9390.38250604.40640-0.630607.753006.22060HepG2HDGF
POLQENSG00000051341.9235.92220457.11610-0.954208.666907.61760HepG2HNRNPA1
POLQENSG00000051341.9415.12000727.33200-0.8091010.690309.07150HepG2HNRNPA2B1
POLQENSG00000051341.9301.57230508.43860-0.753606.165805.16170HepG2HNRNPC
POLQENSG00000051341.9360.14640598.68050-0.733209.109007.90540HepG2HNRNPF
POLQENSG00000051341.9360.21350721.01660-1.0012018.1663016.58090HepG2HNRNPL
POLQENSG00000051341.9313.37730723.46480-1.2070015.2742013.96230HepG2HNRNPLL
POLQENSG00000051341.9370.19590589.53120-0.671306.534205.46450HepG2IGF2BP1
POLQENSG00000051341.954.79090223.10870-2.0257016.2847014.81340HepG2IGF2BP2
POLQENSG00000051341.9315.31830515.92410-0.710309.195507.93700HepG2ILF2
POLQENSG00000051341.9236.83840121.487300.963005.273403.55540HepG2KHDRBS1
POLQENSG00000051341.9421.02180578.71310-0.459004.627703.31600HepG2KIF1C
POLQENSG00000051341.9465.67550878.21500-0.915204.256403.22120HepG2LARP4
POLQENSG00000051341.9372.79370538.39710-0.530303.791402.46170HepG2LARP7
POLQENSG00000051341.9560.49990236.684201.2437013.5061012.10110HepG2MAGOH
POLQENSG00000051341.9535.53040238.011001.1698010.865909.67630HepG2MATR3
POLQENSG00000051341.9191.34940404.49010-1.079905.671404.20820HepG2METAP2
POLQENSG00000051341.9457.68400737.85300-0.689004.154902.95450HepG2MTPAP
POLQENSG00000051341.9353.77110501.44710-0.503303.293201.96270HepG2NAA15
POLQENSG00000051341.9489.39790641.49420-0.390402.190801.52300HepG2NSUN2
POLQENSG00000051341.960.20270116.47960-0.952202.830101.92930HepG2PABPC1
POLQENSG00000051341.9133.63800216.96660-0.699103.092202.33120HepG2PABPC4
POLQENSG00000051341.9400.33940499.96440-0.320602.082901.33960HepG2PARN
POLQENSG00000051341.9270.88990188.088700.526202.900002.28230HepG2PCBP1
POLQENSG00000051341.9230.10790599.38830-1.3812013.5149011.48990HepG2PCBP2
POLQENSG00000051341.9130.93070447.32280-1.7725020.9576019.04680HepG2PRPF8
POLQENSG00000051341.9337.87590191.378400.820006.445805.67900HepG2PTBP1
POLQENSG00000051341.9337.53570749.14760-1.1502017.5506016.22420HepG2PUF60
POLQENSG00000051341.9567.70620795.21200-0.486206.735705.89480HepG2PUM1
POLQENSG00000051341.9566.46950794.65680-0.488304.860203.98460HepG2PUM2
POLQENSG00000051341.9540.40040644.80260-0.254801.835601.31200HepG2PUS1
POLQENSG00000051341.9313.63920578.47880-0.883204.884103.96230HepG2RAVER1
POLQENSG00000051341.9578.53960800.85530-0.469104.535803.47050HepG2RBM15
POLQENSG00000051341.9142.84210752.76640-2.3978063.2952061.45900HepG2RBM22
POLQENSG00000051341.9309.27480188.118600.717104.467303.62710HepG2RBM25
POLQENSG00000051341.9472.96960649.21990-0.457002.767701.77550HepG2RBM27
POLQENSG00000051341.9317.01010735.59800-1.214404.086902.06470HepG2RBM39
POLQENSG00000051341.9257.83110123.084201.066706.009103.78320HepG2RBM47
POLQENSG00000051341.9388.55210527.19520-0.440202.308601.34270HepG2RCC2
POLQENSG00000051341.9543.89280212.993101.3524020.2329019.02930HepG2NELFE
POLQENSG00000051341.9515.36630198.360801.3774021.1069019.67610HepG2RECQL
POLQENSG00000051341.973.27430644.89820-3.1377069.8884067.61500HepG2RPLP0
POLQENSG00000051341.9159.25500568.14180-1.8349020.3385018.04570HepG2RPS10
POLQENSG00000051341.9101.75310376.04880-1.8858024.5072022.97180HepG2RPS19
POLQENSG00000051341.9245.11720598.75220-1.2885016.2131014.39760HepG2RPS2
POLQENSG00000051341.952.95340128.01920-1.273605.191204.09440HepG2RPS3A
POLQENSG00000051341.973.76730442.49320-2.5846034.4195032.28870HepG2RRP9
POLQENSG00000051341.9489.30290820.05660-0.745004.769403.86940HepG2SF3A3
POLQENSG00000051341.9399.01510716.08380-0.843708.938107.73880HepG2SF3B1
POLQENSG00000051341.9266.49490199.265500.419301.798201.30410HepG2SF3B4
POLQENSG00000051341.9588.39580718.23110-0.287702.605801.92250HepG2SLBP
POLQENSG00000051341.9283.75170589.53340-1.054909.290307.48120HepG2SMNDC1
POLQENSG00000051341.9381.82310562.67630-0.559403.192101.47360HepG2SND1
POLQENSG00000051341.9275.51270796.77000-1.5320015.7780013.92810HepG2SNRNP70
POLQENSG00000051341.9188.60260850.23490-2.1725067.4847065.85940HepG2SRFBP1
POLQENSG00000051341.9974.97150207.983502.2288072.3010070.64030HepG2SRSF1
POLQENSG00000051341.9508.72190770.51840-0.599003.728702.54760HepG2SRSF3
POLQENSG00000051341.9254.71870588.17750-1.2073020.3631018.79330HepG2SRSF7
POLQENSG00000051341.9336.53430540.58730-0.683803.107501.82650HepG2SUB1
POLQENSG00000051341.9706.38290841.19940-0.252001.893001.36080HepG2SUCLG1
POLQENSG00000051341.9353.40100498.27980-0.495603.161602.16300HepG2SUPT6H
POLQENSG00000051341.996.13410577.26840-2.5861041.5078039.50600HepG2SUPV3L1
POLQENSG00000051341.9504.69010186.925701.4328022.1136020.74200HepG2TAF15
POLQENSG00000051341.9276.09470705.16990-1.3528019.5280017.92460HepG2TARDBP
POLQENSG00000051341.9359.79530157.911001.188005.947804.44410HepG2TBRG4
POLQENSG00000051341.9161.33670386.91980-1.2620010.466208.77590HepG2TFIP11
POLQENSG00000051341.9283.54880171.778400.722904.565903.49970HepG2TIA1
POLQENSG00000051341.999.30720490.84750-2.3053043.3076041.77300HepG2TIAL1
POLQENSG00000051341.9254.10990495.16090-0.9624013.5371012.42580HepG2TRIM56
POLQENSG00000051341.9419.64490631.15480-0.588803.581502.87050HepG2U2AF1
POLQENSG00000051341.9150.46090841.50870-2.4836013.5405011.27530HepG2U2AF2
POLQENSG00000051341.9589.17490774.57370-0.394702.255201.50420HepG2UBE2L3
POLQENSG00000051341.9260.69950727.26420-1.4801035.1615033.25330HepG2UPF1
POLQENSG00000051341.9429.14590747.53070-0.800708.948007.19210HepG2UTP18
POLQENSG00000051341.976.59290799.85230-3.38450132.22610130.03070HepG2ZNF622
POLQENSG00000051341.9716.392101177.71230-0.7172013.3191012.17460K562AGGF1
POLQENSG00000051341.9984.494201294.07190-0.394502.712401.74310K562AKAP8
POLQENSG00000051341.9660.513801225.44930-0.8917013.6566012.03600K562AKAP8L
POLQENSG00000051341.91037.722601285.76530-0.309203.057602.09750K562ATP5C1
POLQENSG00000051341.9590.44590744.69490-0.334802.750401.44360K562BCCIP
POLQENSG00000051341.9951.448801407.47550-0.564907.783405.79910K562CCDC124
POLQENSG00000051341.91113.834401375.36890-0.304303.021901.86190K562CPEB4
POLQENSG00000051341.9439.63340630.02240-0.519103.437102.25920K562DDX3X
POLQENSG00000051341.9858.812701423.34780-0.7289015.6294014.19480K562DDX47
POLQENSG00000051341.9998.490201318.75750-0.401405.009603.77720K562DKC1
POLQENSG00000051341.9418.87050634.23790-0.598503.585402.53720K562EFTUD2
POLQENSG00000051341.9398.37950679.23360-0.769804.386103.04880K562EIF3D
POLQENSG00000051341.9472.88510641.49880-0.440003.498302.60930K562EIF3G
POLQENSG00000051341.9729.22840984.15230-0.432503.492902.53090K562FIP1L1
POLQENSG00000051341.9594.44780791.35920-0.412802.805201.94560K562FMR1
POLQENSG00000051341.9506.14670670.74010-0.406202.423901.57250K562FTO
POLQENSG00000051341.9442.37050684.51930-0.629807.239006.32320K562FXR1
POLQENSG00000051341.9949.95600719.894400.400002.156701.54370K562G3BP2
POLQENSG00000051341.9528.974101181.84560-1.1598021.6526019.43480K562GRSF1
POLQENSG00000051341.9567.48670788.49340-0.474503.083001.77460K562HNRNPK
POLQENSG00000051341.9767.841201286.27050-0.7443011.069008.83110K562HNRNPL
POLQENSG00000051341.9440.08300809.49740-0.879308.749806.92670K562HNRNPM
POLQENSG00000051341.9682.719801334.27610-0.9667015.0119013.23310K562HSPD1
POLQENSG00000051341.9545.83530802.68020-0.556405.301103.55320K562IGF2BP3
POLQENSG00000051341.9941.217901300.55620-0.466504.543903.44580K562KIF1C
POLQENSG00000051341.9342.21510634.06850-0.889706.773905.24580K562KRR1
POLQENSG00000051341.9880.750101244.91320-0.499204.821403.28090K562MAK16
POLQENSG00000051341.91041.731301456.94470-0.484005.586704.20530K562MBNL1
POLQENSG00000051341.9552.38040724.85860-0.392002.847901.95730K562METAP2
POLQENSG00000051341.9779.26890972.42410-0.319503.151302.28920K562MTPAP
POLQENSG00000051341.9694.832101021.20850-0.555503.649102.60360K562NAA15
POLQENSG00000051341.9443.95160624.54690-0.492402.957501.60710K562NONO
POLQENSG00000051341.9552.22780852.91390-0.627102.548401.60870K562PABPN1
POLQENSG00000051341.91242.01560963.945200.365602.361301.59380K562PCBP3
POLQENSG00000051341.9908.13360739.412200.296402.210201.49450K562POLR2G
POLQENSG00000051341.9661.651001117.23360-0.755809.307807.56520K562PPIG
POLQENSG00000051341.9383.24090617.18250-0.687404.383303.44040K562PRPF8
POLQENSG00000051341.9426.87260618.58260-0.535202.353801.52570K562PSIP1
POLQENSG00000051341.9613.43520805.97540-0.393803.206602.49780K562PTBP1
POLQENSG00000051341.91220.559401916.65520-0.651006.328405.09570K562PUF60
POLQENSG00000051341.91571.368701997.50070-0.346203.101202.08760K562PUM2
POLQENSG00000051341.9572.582001215.40790-1.0859017.4617016.13930K562PUS1
POLQENSG00000051341.9753.250501184.15030-0.652709.909308.81430K562RBM15
POLQENSG00000051341.9338.03690564.19260-0.739005.537404.12780K562RCC2
POLQENSG00000051341.9551.21780813.45460-0.561404.732103.25860K562NELFE
POLQENSG00000051341.9276.07690628.78370-1.187508.393606.95620K562RPS19
POLQENSG00000051341.9572.63460748.86670-0.387103.180402.26270K562SF3B4
POLQENSG00000051341.9542.79270746.06700-0.458903.443102.25090K562SRSF5
POLQENSG00000051341.91695.904901291.243500.393203.352701.83760K562SSRP1
POLQENSG00000051341.9595.25290741.60360-0.317102.173601.44530K562SYNCRIP
POLQENSG00000051341.9530.76370799.70650-0.591404.149103.27670K562TARDBP
POLQENSG00000051341.9533.61800771.38300-0.531605.047403.89020K562TIA1
POLQENSG00000051341.9590.93760756.73810-0.356802.300401.32510K562TRA2A
POLQENSG00000051341.9379.36380631.90040-0.736104.615803.32240K562TRIM56
POLQENSG00000051341.9506.78030698.15250-0.462202.807001.70550K562U2AF1
POLQENSG00000051341.9570.13700720.92810-0.338502.415101.66440K562U2AF2
POLQENSG00000051341.9954.961801145.63190-0.262602.645901.94310K562UPF1
POLQENSG00000051341.9784.402201232.19740-0.651603.289601.83780K562UTP18
POLQENSG00000051341.9817.934001019.37290-0.317603.543102.59320K562WDR43
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for POLQ is not available on ENCORE database.





2 RBPs can affect the splicing of POLQ :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEPOLQENSG00000051341.9chr3-121190836121191011121187151121187278121195386121195580-0.226000.005460.05000excludedK562AQR
SEPOLQENSG00000051341.9chr3-121178896121179081121168161121168273121186365121186487-0.469000.000050.00268excludedHepG2SF3A3
A3SSPOLQENSG00000051341.9chr3-1211517641211519191211517641211518801211549681211551220.119000.014080.07083longerK562AQR
MXEPOLQENSG00000051341.9chr3-121190836121191011121192196121192334121187151121187278121195386121195580-0.183000.012530.076042includedK562AQR

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for POLQ is not avaliable on ENCORE database.