MSI2

General Information

Gene Name : MSI2
Gene ID : ENSG00000153944.10
Essential Gene : No

Functions

Translation regulation

Localization(RBPImage: MSI2)

Nuclei
Nucleoplasm
Mutually Exclusive from Nucleolus
Speckles
Cytoplasm
Compartment/Organelle
Mitochondria
Cell Cortex

Domains (AlphaFold: MSI2)

RRM

Antibody Validation

GeneTex: GTX117808

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	MSI2	ENSG00000153944.10	55.55	41.78	48.66	ENCSR000AEF
HepG2	MSI2	ENSG00000153944.10	64.07	82.04	73.06	ENCSR985KAT
K562	MSI2	ENSG00000153944.10	48.14	37.85	43.00	ENCSR000AEO

Assays

2 Released experiments are available on ENCORE database.

Assay Type	Exp_Name	ENCODE ID	Target label	Biosample	Status	Linked Antibody	Controls	Method	Note
knockdown followed by RNA-seq	MSI2-BGKLV25-K562	ENCSR169QQW	MSI2	K562	Released		ENCSR620PUP	shRNA	KD% = 82.0,90.9
knockdown followed by RNA-seq	MSI2-BGHLV30-HepG2	ENCSR896MMU	MSI2	HepG2	Released		ENCSR067GHD	shRNA	KD% = 68.1,73.6

eCLIP

No eCLIP experiment available

Antibody Validation

GeneName	Antibody_DCC_ID	Product_ID	Lot_ID	Phosphate	HepG2 Primary Validation	K562 Primary Validation	HepG2 Secondary Validation	K562 Secondary Validation
MSI2	ENCAB529VOS	GTX117808	40415			Released, ENCODE3	BGHLV30-43, Released, ENCODE3	BGKLV25-33, Released, ENCODE3

KD RNA-Seq

GeneName	Cell_Line	Method	Exp_ID	Control_ID	Sample_reps	Control_reps	KD%	Status	Project
MSI2	K562	shRNA	ENCSR169QQW	ENCSR620PUP	MSI2_BGKLV25-33,MSI2_BGKLV25-34	NT_BGKLV25-1,NT_BGKLV25-2	82.0,90.9	Released	ENCODE3
MSI2	HepG2	shRNA			BGHLV27-35,BGHLV27-36	BGHLV27-1,BGHLV27-2		NotSatisfied	ENCODE3
MSI2	HepG2	shRNA	ENCSR896MMU	ENCSR067GHD	MSI2_BGHLV30-43,MSI2_BGHLV30-44	NT_BGHLV30-1,NT_BGHLV30-2	68.1,73.6	Released	ENCODE3

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

MSI2: Click to RBP Image Database

Nuclei

Nucleoplasm

Mutually Exclusive from Nucleolus

Speckles

Cytoplasm

Compartment/Organelle

Mitochondria

Cell Cortex

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela
MSI2	Product_ID: GTX117808 Lot_ID: 40415 Source: GeneTex Target Name: MSI2-human

Summary
Proteins Bound to RBP RNA

RNA Targets

eCLIP assay for MSI2 is not avaliable on ENCORE database.

Proteins bound to RNA

MSI2 RNA is bound by 65 proteins.

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eCLIP assay for MSI2 is not avaliable on ENCORE database.

65 proteins are bound to MSI2 RNA:

Show entries

Search:

Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr17	55726858	55727001	+	intron-Distal	9.46818	151.02033	K562	AGGF1
chr17	55334082	55334131	+	5'-UTR,CDS,intron-Distal	5.15448	83.03773	HepG2	PRPF4
chr17	55726917	55727010	+	intron-Distal	7.40073	82.84987	HepG2	HNRNPL
chr17	55757038	55757142	+	3'-UTR	5.37880	76.02705	K562	PUM2
chr17	55419217	55419337	+	intron-Distal	6.18385	74.39860	HepG2	PTBP1
chr17	55334090	55334161	+	5'-UTR,CDS,intron-Distal	5.13080	71.47481	K562	DDX24
chr17	55347244	55347320	+	intron-Distal	5.89855	62.24936	HepG2	HNRNPM
chr17	55334090	55334164	+	5'-UTR,CDS,intron-Distal	5.54510	56.93712	HepG2	GTF2F1
chr17	55726830	55726917	+	intron-Distal	6.16834	51.55194	HepG2	HNRNPL
chr17	55726878	55727004	+	intron-Distal	6.49381	49.63279	HepG2	XPO5
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

Showing 1 to 10 of 521 entries

eCLIP assay for MSI2 is not avaliable on ENCORE database.

Diffrential Expression

7,239 differentially expressed genes after Knockdown/Knockout MSI2 protein.

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93 RBPs can affect the levels of MSI2.

CanvasJS.com

7,239 differentially expressed genes after Knockdown/Knockout MSI2 protein :

Only display 100 entries as example. Please click "View All" button to see all 7,239 entries.

Show entries

Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
ITGA3	ENSG00000005884.13	3159.52340	87.47150	5.17470	185.69240	181.62150	HepG2	MSI2
GDE1	ENSG00000006007.7	4118.31030	1603.87560	1.36040	46.16560	43.59300	HepG2	MSI2
PROM1	ENSG00000007062.7	1090.52960	448.68370	1.28120	25.44140	23.35950	HepG2	MSI2
ANLN	ENSG00000011426.6	1290.64550	2928.33980	-1.18200	24.97530	22.90440	HepG2	MSI2
NFIX	ENSG00000008441.12	320.09580	806.59080	-1.33330	23.30930	21.27970	HepG2	MSI2
RHOBTB2	ENSG00000008853.12	866.46670	365.06700	1.24690	20.55480	18.62380	HepG2	MSI2
FKBP4	ENSG00000004478.5	816.52930	1612.20590	-0.98150	19.16860	17.28520	HepG2	MSI2
IDS	ENSG00000010404.13	1720.16340	895.34720	0.94190	17.96730	16.12300	HepG2	MSI2
ASB4	ENSG00000005981.8	257.88380	66.15680	1.96270	17.27010	15.45810	HepG2	MSI2
KDM1A	ENSG00000004487.11	1889.67260	3100.61200	-0.71440	13.03750	11.41920	HepG2	MSI2
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 100 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

93 RBPs can affect the gene expression of MSI2 :

Show entries

Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
MSI2	ENSG00000153944.6	2432.33460	4913.83090	-1.01450	53.82170	52.26290	HepG2	SSB
MSI2	ENSG00000153944.6	1318.15960	3915.92110	-1.57080	51.74210	47.92220	K562	MSI2
MSI2	ENSG00000153944.6	1198.39340	3282.87990	-1.45390	40.72900	38.25460	HepG2	MSI2
MSI2	ENSG00000153944.6	2556.90640	3987.30940	-0.64100	28.91020	27.19360	HepG2	SMN1
MSI2	ENSG00000153944.6	1850.08030	3424.36080	-0.88820	28.65300	26.49020	HepG2	PPIL4
MSI2	ENSG00000153944.6	2323.58420	4642.86120	-0.99870	26.23570	24.65170	HepG2	PUF60
MSI2	ENSG00000153944.6	2334.70720	3742.45450	-0.68070	25.42480	23.90610	HepG2	PUS1
MSI2	ENSG00000153944.6	1957.73240	3441.68190	-0.81390	25.14590	23.26030	HepG2	DNAJC21
MSI2	ENSG00000153944.6	2068.96050	3730.81810	-0.85060	23.02730	21.84670	HepG2	TIAL1
MSI2	ENSG00000153944.6	2277.02850	3411.11490	-0.58310	21.03750	19.39450	HepG2	DNAJC2
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 103 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

The Knockdown/knockout RNA-Seq assay for MSI2 is not available on ENCORE database.

30 RBPs can affect the splicing of MSI2 :

Show entries

Search:

Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	FDR	is_included	Cell Line	Affected by RBP
SE	MSI2	ENSG00000153944.6	chr17	+	55754347	55754420	55752332	55752487	55756909	55762046	0.17500	0.00001	included	HepG2	G3BP1
SE	MSI2	ENSG00000153944.6	chr17	+	55754347	55754420	55752332	55752487	55756909	55762046	-0.25300	0.00000	excluded	HepG2	U2AF1
SE	MSI2	ENSG00000153944.6	chr17	+	55754347	55754420	55752332	55752487	55756909	55762046	-0.26100	0.00010	excluded	K562	AKAP8L
SE	MSI2	ENSG00000153944.6	chr17	+	55754347	55754420	55752332	55752487	55756909	55762046	0.08000	0.00157	included	HepG2	HNRNPM
SE	MSI2	ENSG00000153944.6	chr17	+	55754347	55754420	55752332	55752487	55756909	55762046	0.13500	0.00001	included	HepG2	QKI
SE	MSI2	ENSG00000153944.6	chr17	+	55334826	55334908	55334402	55334499	55335630	55335715	-0.09800	0.00000	excluded	HepG2	U2AF2
SE	MSI2	ENSG00000153944.6	chr17	+	55754347	55754420	55752332	55752487	55756909	55762046	0.34500	0.00017	included	K562	FXR1
SE	MSI2	ENSG00000153944.6	chr17	+	55754347	55754420	55752332	55752487	55756909	55762046	-0.10300	0.00047	excluded	HepG2	LARP4
SE	MSI2	ENSG00000153944.6	chr17	+	55754347	55754420	55752332	55752487	55756909	55762046	-0.37300	0.00002	excluded	K562	RBM15
SE	MSI2	ENSG00000153944.6	chr17	+	55754347	55754420	55752332	55752487	55756909	55762046	-0.31900	0.00000	excluded	K562	AGGF1

Showing 1 to 10 of 35 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

MSI2

General Information

Functions

Localization(RBPImage: MSI2)

Domains (AlphaFold: MSI2)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

eCLIP assay for MSI2 is not avaliable on ENCORE database.

65 proteins are bound to MSI2 RNA:

eCLIP assay for MSI2 is not avaliable on ENCORE database.

Diffrential Expression

7,239 differentially expressed genes after Knockdown/Knockout MSI2 protein :

93 RBPs can affect the gene expression of MSI2 :

The Knockdown/knockout RNA-Seq assay for MSI2 is not available on ENCORE database.

30 RBPs can affect the splicing of MSI2 :

The Knockdown/knockout RNA-Seq assay for MSI2 is not avaliable on ENCORE database.