HFE

General Information

Gene Name       : HFE
Gene ID             : ENSG00000010704.18
Essential Gene : No

Functions

Localization

Domains (AlphaFold: HFE)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878HFEENSG00000010704.183.191.512.35ENCSR000AEF
HepG2HFEENSG00000010704.184.094.164.12ENCSR985KAT
K562HFEENSG00000010704.180.560.600.58ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for HFE is not avaliable on ENCORE database.



Proteins bound to RNA
  • HFE RNA is bound by 1 proteins.  







eCLIP assay for HFE is not avaliable on ENCORE database.





1 proteins are bound to HFE RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr62609557726095697+3'-UTR4.520905.64948HepG2UPF1
chr62609656826096686+3'-UTR4.5975810.16433HepG2UPF1
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for HFE is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for HFE is not available on ENCORE database.

  • 61 RBPs can affect the levels of HFE.  








The Knockdown/knockout RNA-Seq assay for HFE is not available on ENCORE database.





61 RBPs can affect the gene expression of HFE :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
HFEENSG00000010704.1487.11180192.67720-1.145208.077007.14860HepG2ACO1
HFEENSG00000010704.14116.84940267.47590-1.1948010.203309.02260HepG2AUH
HFEENSG00000010704.1493.62860155.28420-0.729902.415701.54130HepG2BCCIP
HFEENSG00000010704.14241.65690134.921200.840703.776502.74000HepG2BCLAF1
HFEENSG00000010704.14307.73320223.269700.462801.976701.31660HepG2CIRBP
HFEENSG00000010704.14178.7427070.078501.350706.293905.28680HepG2CPSF6
HFEENSG00000010704.14101.67560157.68110-0.633002.495701.53220HepG2YBX3
HFEENSG00000010704.1447.1306095.90570-1.025003.284702.11910HepG2CSTF2
HFEENSG00000010704.1478.01000266.16590-1.7706017.9840016.63160HepG2CELF1
HFEENSG00000010704.14422.11480272.061200.633603.740503.02370HepG2DDX3X
HFEENSG00000010704.1436.5030079.58030-1.124402.624701.67460HepG2DDX59
HFEENSG00000010704.14128.83270233.74160-0.859404.076303.33860HepG2DDX6
HFEENSG00000010704.14309.38110224.666300.461501.888801.38810HepG2EIF2S1
HFEENSG00000010704.14100.69540241.75390-1.263506.723505.68390HepG2EIF4B
HFEENSG00000010704.14164.77850282.33830-0.776905.031003.95720HepG2EIF4G1
HFEENSG00000010704.14221.90880307.12010-0.468802.659702.06780HepG2ETF1
HFEENSG00000010704.14122.60360188.30590-0.619102.677201.85620HepG2EWSR1
HFEENSG00000010704.14167.40000246.74350-0.559702.332901.51900HepG2G3BP2
HFEENSG00000010704.14102.47740156.32570-0.609201.871601.32840HepG2HNRNPA1
HFEENSG00000010704.1476.35320172.72880-1.177707.616206.64820HepG2HNRNPU
HFEENSG00000010704.14120.36930236.20620-0.972605.474704.55470HepG2IGF2BP2
HFEENSG00000010704.1498.25750215.26690-1.131502.029301.32680HepG2LARP4
HFEENSG00000010704.14161.11830252.02320-0.645402.678602.05730HepG2MATR3
HFEENSG00000010704.1475.85640125.41470-0.725402.467301.70160HepG2MSI2
HFEENSG00000010704.14163.44680283.71890-0.795605.227704.18480HepG2NOL12
HFEENSG00000010704.14171.79420270.85520-0.656803.289502.64760HepG2PUF60
HFEENSG00000010704.14158.86280287.32390-0.854905.510304.57890HepG2PUM2
HFEENSG00000010704.14173.96280253.21580-0.541601.876001.34680HepG2QKI
HFEENSG00000010704.1472.27300154.63250-1.097303.581002.78110HepG2RAVER1
HFEENSG00000010704.14127.57480256.69100-1.008707.062706.32450HepG2RBM22
HFEENSG00000010704.14157.04450260.15790-0.728202.832702.28650HepG2NELFE
HFEENSG00000010704.1471.08610136.83590-0.944803.711002.93880HepG2RPLP0
HFEENSG00000010704.14118.55520204.80070-0.788703.363802.48230HepG2RPS2
HFEENSG00000010704.14139.4094079.852000.803802.655101.87110HepG2RPS3A
HFEENSG00000010704.1464.08050116.48410-0.862202.539601.78300HepG2RRP9
HFEENSG00000010704.1489.72870153.82590-0.777703.555902.84160HepG2SAFB2
HFEENSG00000010704.1474.86510167.19670-1.159205.831404.82830HepG2SF3A3
HFEENSG00000010704.14108.55910179.39240-0.724603.696802.97150HepG2SMN1
HFEENSG00000010704.14219.60560289.91490-0.400702.031701.58180HepG2SRFBP1
HFEENSG00000010704.14145.45480254.04600-0.804503.247302.74580HepG2SRSF1
HFEENSG00000010704.14160.86300267.45920-0.733504.495403.73140HepG2SRSF5
HFEENSG00000010704.14161.09120251.70060-0.643803.981003.38980HepG2SSB
HFEENSG00000010704.14219.13870304.14990-0.472902.389801.80380HepG2SUCLG1
HFEENSG00000010704.14173.75400104.635700.731603.401402.36650HepG2SUPT6H
HFEENSG00000010704.1482.78170151.98470-0.876503.051602.34580HepG2SUPV3L1
HFEENSG00000010704.1493.12610167.85900-0.850004.105803.52240HepG2TIAL1
HFEENSG00000010704.14181.14930264.65380-0.546902.393601.58490HepG2TUFM
HFEENSG00000010704.14169.23720280.15790-0.727203.008102.13640HepG2UBE2L3
HFEENSG00000010704.1425.9949089.77740-1.788107.055705.83550HepG2UCHL5
HFEENSG00000010704.1495.66020143.15710-0.581601.897001.38140HepG2UTP3
HFEENSG00000010704.14286.50110163.077700.812906.701705.94760HepG2ZNF622
HFEENSG00000010704.1448.140704.515203.414303.000002.08970K562BOP1
HFEENSG00000010704.1449.0865020.612101.251702.421501.33260K562CCDC124
HFEENSG00000010704.1424.447104.802002.347902.829102.03800K562CPSF6
HFEENSG00000010704.1475.778404.296004.1406015.8128014.30450K562EIF2S2
HFEENSG00000010704.1426.048106.117602.090002.562101.77300K562EIF4A3
HFEENSG00000010704.1432.133804.884002.717904.276403.21340K562FMR1
HFEENSG00000010704.1424.065504.138802.539602.325001.49090K562FTO
HFEENSG00000010704.1423.520206.362101.886202.305801.74560K562FXR1
HFEENSG00000010704.1425.619105.720502.162902.305501.61230K562GRSF1
HFEENSG00000010704.1420.330504.604502.142402.130301.59780K562HNRNPC
HFEENSG00000010704.1430.197006.023002.325703.095202.30150K562PRPF8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for HFE is not available on ENCORE database.





3 RBPs can affect the splicing of HFE :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEHFEENSG00000010704.14chr6+260910682609133226087508260877442609154126091817-0.408000.000520.01560excludedHepG2HNRNPK
RIHFEENSG00000010704.14chr6+2609106826091817260910682609133226091541260918170.370000.000970.01220includedHepG2RBM22
MXEHFEENSG00000010704.14chr6+26091068260913322609154126091817260875082608774426092912260931880.642000.000080.004501includedHepG2HNRNPU
MXEHFEENSG00000010704.14chr6+2609106826091332260915412609181726087508260877442609291226093188-0.374000.002190.048282includedHepG2HNRNPK
MXEHFEENSG00000010704.14chr6+2609106826091332260915412609181726087632260877442609295426093188-0.425000.002050.046182includedHepG2HNRNPK

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for HFE is not avaliable on ENCORE database.