LAP3

General Information

Gene Name       : LAP3
Gene ID             : ENSG00000002549.12
Essential Gene : No

Functions

Localization

Domains (AlphaFold: LAP3)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878LAP3ENSG00000002549.12143.35142.67143.01ENCSR000AEF
HepG2LAP3ENSG00000002549.1273.7793.2783.52ENCSR985KAT
K562LAP3ENSG00000002549.1282.9188.6985.80ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for LAP3 is not avaliable on ENCORE database.



Proteins bound to RNA
  • LAP3 RNA is bound by 18 proteins.  







eCLIP assay for LAP3 is not avaliable on ENCORE database.





18 proteins are bound to LAP3 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr41758523717585264+3'-UTR,CDS4.250864.42709HepG2G3BP1
chr41760934317609445+3'-UTR5.096475.25980HepG2SUB1
chr41760941817609492+3'-UTR4.225993.55598HepG2ZC3H11A
chr41758513817585257+3'-UTR,CDS3.445599.53024HepG2GRWD1
chr41758526017585323+3'-UTR,CDS,intron-Proximal3.900195.34978HepG2PRPF8
chr41758671517586757+3'-UTR,CDS3.019033.92673HepG2G3BP1
chr41758510517585266+3'-UTR,CDS,intron-Proximal3.428865.22707K562GRWD1
chr41757918017579239+5'-UTR,CDS,intron-Proximal5.7465812.32183HepG2PRPF8
chr41757910017579191+5'-UTR,CDS,intron-Proximal5.1859614.74628K562DDX3X
chr41759872117598756+CDS,intron-Distal4.064136.53930HepG2G3BP1
chr41760009617600176+CDS,intron-Distal3.697404.04629HepG2G3BP1
chr41759867317598721+CDS,intron-Distal3.462595.76664HepG2G3BP1
chr41758336417583447+CDS,intron-Proximal3.078205.26399HepG2AQR
chr41760007817600096+CDS,intron-Distal,intron-Proximal4.238093.39686HepG2G3BP1
chr41758153717581562+CDS4.176673.61890HepG2G3BP1
chr41758514117585220+CDS3.356567.40344HepG2PPIG
chr41758151517581563+CDS,intron-Proximal3.255783.69481K562UCHL5
chr41758338117583435+CDS,intron-Proximal3.492743.73423K562UCHL5
chr41758398717584017+CDS,intron-Distal,intron-Proximal3.723044.51739HepG2BCLAF1
chr41758338417583434+CDS3.342955.99947HepG2G3BP1
chr41757918817579231+CDS,intron-Proximal4.606493.93614HepG2AQR
chr41759705217597146+CDS3.517924.96885HepG2G3BP1
chr41759713117597238+CDS,intron-Proximal4.7329416.45654HepG2PRPF8
chr41758391017583957+CDS,intron-Distal,intron-Proximal3.115364.70577HepG2G3BP1
chr41759866617598734+CDS,intron-Distal,intron-Proximal3.6193610.05371K562YBX3
chr41758510517585138+CDS,intron-Proximal4.549056.01390HepG2GRWD1
chr41760017117600218+CDS,intron-Distal,intron-Proximal3.870313.86479HepG2PRPF8
chr41758510317585216+CDS,intron-Proximal3.814884.79276K562ZNF622
chr41760902217609053+CDS,intron-Proximal4.324694.25741HepG2G3BP1
chr41758511617585199+CDS3.6834010.80755HepG2G3BP1
chr41760624317606270+CDS3.126903.24162HepG2G3BP1
chr41760614317606215+CDS,intron-Proximal5.001247.71578HepG2SF3B4
chr41758517417585207+CDS3.235094.13994HepG2GRSF1
chr41759048417590547+CDS4.287867.10432HepG2G3BP1
chr41758510517585210+CDS,intron-Proximal4.791328.82226HepG2RPS3
chr41760007817600140+CDS,intron-Distal,intron-Proximal3.258594.49055K562YBX3
chr41760697417607059+intron-Distal3.124223.54232HepG2HNRNPL
chr41760679117606850+intron-Distal3.943933.19026HepG2HNRNPL
chr41760498617605071+intron-Distal3.829113.58660HepG2ILF3
chr41757920717579264+intron-Proximal4.846935.00814HepG2RBM22
chr41758652117586593+intron-Proximal4.433093.59236HepG2AQR
chr41758503817585094+intron-Proximal4.420754.07325HepG2SF3B4
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for LAP3 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for LAP3 is not available on ENCORE database.

  • 120 RBPs can affect the levels of LAP3.  








The Knockdown/knockout RNA-Seq assay for LAP3 is not available on ENCORE database.





120 RBPs can affect the gene expression of LAP3 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
LAP3ENSG00000002549.82231.961401836.840000.281004.242803.52050HepG2ACO1
LAP3ENSG00000002549.83085.411402479.086400.315601.960901.50390HepG2AKAP1
LAP3ENSG00000002549.82459.879501845.308400.414607.600106.40420HepG2AKAP8L
LAP3ENSG00000002549.82523.011902051.205200.298602.066001.38350HepG2ASCC1
LAP3ENSG00000002549.82563.879301862.174800.461205.257403.38420HepG2ATP5C1
LAP3ENSG00000002549.83057.734102631.119500.216702.749602.06650HepG2AUH
LAP3ENSG00000002549.81331.719601850.92500-0.475005.045404.26820HepG2BOP1
LAP3ENSG00000002549.81657.847302564.90680-0.629605.491204.09480HepG2CCAR1
LAP3ENSG00000002549.81240.250802741.44180-1.1443012.1595010.59630HepG2CNOT7
LAP3ENSG00000002549.8850.010001699.23880-0.9993016.8523015.32230HepG2CPSF6
LAP3ENSG00000002549.82538.872401699.463200.579008.340106.52270HepG2CPSF7
LAP3ENSG00000002549.83763.739102643.302100.5097011.5087010.37350HepG2CELF1
LAP3ENSG00000002549.81877.080802842.24790-0.5985019.8852018.23690HepG2DAZAP1
LAP3ENSG00000002549.82104.319901758.439100.259002.774501.61300HepG2DDX1
LAP3ENSG00000002549.81093.284502013.75150-0.8812016.2596014.77890HepG2DDX21
LAP3ENSG00000002549.81425.311601969.98870-0.466906.003004.66150HepG2DDX24
LAP3ENSG00000002549.81086.251002374.71150-1.1284019.9304018.41470HepG2DDX3X
LAP3ENSG00000002549.81280.758301757.30790-0.456407.681806.66120HepG2DKC1
LAP3ENSG00000002549.8760.233701724.25140-1.1815036.8861034.67260HepG2DNAJC21
LAP3ENSG00000002549.81767.341101366.338700.371202.946901.80470HepG2EFTUD2
LAP3ENSG00000002549.81354.106502167.08980-0.678406.971705.95700HepG2EIF4A3
LAP3ENSG00000002549.81033.155002110.10780-1.0303011.6895010.32360HepG2EIF4B
LAP3ENSG00000002549.83632.921502804.009600.373506.999505.77980HepG2EIF4G1
LAP3ENSG00000002549.81638.065702686.06940-0.7135010.853509.30010HepG2EIF4G2
LAP3ENSG00000002549.81369.508601787.73430-0.384503.424402.21480HepG2ESF1
LAP3ENSG00000002549.82606.678403020.81600-0.212702.089701.55230HepG2ETF1
LAP3ENSG00000002549.82579.415601794.748400.523207.424906.06020HepG2EWSR1
LAP3ENSG00000002549.81609.603302186.72750-0.442103.866503.05780HepG2FXR1
LAP3ENSG00000002549.8891.722301184.63500-0.409803.272402.28800HepG2GEMIN5
LAP3ENSG00000002549.81560.215202537.63890-0.701705.724604.11360HepG2GRSF1
LAP3ENSG00000002549.81532.058102317.42930-0.597104.492302.71130HepG2HNRNPA0
LAP3ENSG00000002549.8894.139701740.77010-0.9612017.8822016.47230HepG2HNRNPA1
LAP3ENSG00000002549.83222.645202612.083500.302904.729503.55960HepG2HNRNPA2B1
LAP3ENSG00000002549.81019.419101936.28210-0.9255016.9236015.35150HepG2HNRNPC
LAP3ENSG00000002549.82515.780802054.206900.292302.252601.61800HepG2HNRNPK
LAP3ENSG00000002549.83145.379802589.085200.280705.478004.55680HepG2HNRNPL
LAP3ENSG00000002549.81462.317601838.20020-0.330002.402101.81040HepG2HNRNPLL
LAP3ENSG00000002549.81224.563301923.48080-0.6515015.8464014.49240HepG2HNRNPU
LAP3ENSG00000002549.81652.278701964.77240-0.249903.843602.99380HepG2ILF2
LAP3ENSG00000002549.81876.933602672.47040-0.509803.382501.90070HepG2ILF3
LAP3ENSG00000002549.81927.117002611.46590-0.438403.087101.81270HepG2KHDRBS1
LAP3ENSG00000002549.81931.663201678.981200.202202.524401.54790HepG2KIF1C
LAP3ENSG00000002549.81277.329102187.49200-0.7761010.035408.80910HepG2MAGOH
LAP3ENSG00000002549.83167.630602199.698500.526004.830004.01440HepG2MATR3
LAP3ENSG00000002549.81905.957301392.476600.452802.599101.57790HepG2METAP2
LAP3ENSG00000002549.81379.308901686.46390-0.290102.484301.71610HepG2MSI2
LAP3ENSG00000002549.81204.761901874.79260-0.638004.389203.15110HepG2MTPAP
LAP3ENSG00000002549.81942.689301416.178000.456004.964403.34660HepG2NAA15
LAP3ENSG00000002549.81432.690302505.44600-0.806305.788504.47060HepG2PABPC1
LAP3ENSG00000002549.81353.914502004.95680-0.566405.599004.58360HepG2PABPC4
LAP3ENSG00000002549.82365.036201903.920200.312804.539603.48460HepG2PARN
LAP3ENSG00000002549.82347.936801726.881700.443108.360207.11440HepG2PRPF4
LAP3ENSG00000002549.82209.345602690.36190-0.284202.569801.99290HepG2PUF60
LAP3ENSG00000002549.83329.499902853.845700.222302.075201.48920HepG2PUM2
LAP3ENSG00000002549.81449.812502303.66620-0.6681013.2428012.02380HepG2QKI
LAP3ENSG00000002549.83051.356802227.672900.453802.189901.55650HepG2RAVER1
LAP3ENSG00000002549.81303.385401710.47340-0.392103.009701.90350HepG2RCC2
LAP3ENSG00000002549.81731.767802367.36480-0.451008.137707.29680HepG2NELFE
LAP3ENSG00000002549.81901.305602205.03760-0.213802.142501.59090HepG2RECQL
LAP3ENSG00000002549.82167.003002674.29480-0.303502.654401.98180HepG2RPLP0
LAP3ENSG00000002549.81475.773901942.55390-0.396503.782202.85060HepG2RPS2
LAP3ENSG00000002549.81517.250602752.11110-0.859109.155007.73050HepG2RPS3A
LAP3ENSG00000002549.81181.525401712.94640-0.5358011.6395010.45910HepG2SAFB2
LAP3ENSG00000002549.81333.651501819.43730-0.448104.433003.55900HepG2SF3B1
LAP3ENSG00000002549.82409.272101997.587700.270204.783003.97490HepG2SMN1
LAP3ENSG00000002549.81547.154902169.30240-0.487603.361201.59630HepG2SND1
LAP3ENSG00000002549.81483.188902024.44940-0.448802.405301.67910HepG2SNRNP70
LAP3ENSG00000002549.81573.853902851.75450-0.8575033.4355032.19740HepG2SRFBP1
LAP3ENSG00000002549.82340.495701880.690500.315505.320804.60010HepG2SRSF9
LAP3ENSG00000002549.81968.116002476.03750-0.331205.473804.80040HepG2SSB
LAP3ENSG00000002549.82301.328303020.98550-0.392609.128008.10870HepG2SUCLG1
LAP3ENSG00000002549.81293.371201721.36310-0.412402.553801.90090HepG2SUPV3L1
LAP3ENSG00000002549.81310.291402077.98620-0.6653013.9368012.82050HepG2TAF15
LAP3ENSG00000002549.81384.959401791.75770-0.371503.134402.36770HepG2TARDBP
LAP3ENSG00000002549.81735.027401153.816400.588405.827904.46290HepG2TFIP11
LAP3ENSG00000002549.81298.263001869.03140-0.525707.844407.08090HepG2TIAL1
LAP3ENSG00000002549.81520.880201939.03360-0.350405.665604.72260HepG2UPF1
LAP3ENSG00000002549.8605.146801576.44490-1.3813016.8460014.38750HepG2UPF2
LAP3ENSG00000002549.83017.066301993.104600.5980014.8681012.71060HepG2UTP18
LAP3ENSG00000002549.81216.903702465.03310-1.0184011.996609.78670HepG2XPO5
LAP3ENSG00000002549.81776.765702450.12750-0.463602.883101.80300HepG2XRCC6
LAP3ENSG00000002549.81883.677601644.329400.196001.945301.45390K562AGGF1
LAP3ENSG00000002549.81490.888502931.99820-0.9757016.9427015.65210K562AQR
LAP3ENSG00000002549.82150.480801795.230800.260402.776101.86100K562ATP5C1
LAP3ENSG00000002549.81547.050301985.91200-0.360304.846903.02790K562BCCIP
LAP3ENSG00000002549.81435.297601919.08720-0.419107.264005.68330K562BCLAF1
LAP3ENSG00000002549.8872.299401533.88060-0.8143011.124009.32990K562BOP1
LAP3ENSG00000002549.81571.656802065.22480-0.394003.013901.52170K562BUD13
LAP3ENSG00000002549.81875.659002891.25700-0.624302.639701.60750K562CNOT7
LAP3ENSG00000002549.81040.823701630.93630-0.648009.806608.31360K562CPSF6
LAP3ENSG00000002549.8913.502901265.87780-0.470704.119502.81400K562DDX3X
LAP3ENSG00000002549.83696.625202839.249200.380607.549606.54490K562DDX47
LAP3ENSG00000002549.81128.623001759.93680-0.641006.816004.27930K562DDX51
LAP3ENSG00000002549.82308.608001841.192000.326304.367703.23140K562DKC1
LAP3ENSG00000002549.81004.421901629.39490-0.698008.738707.02620K562EFTUD2
LAP3ENSG00000002549.81751.120302647.82620-0.596506.261505.24340K562EIF2S2
LAP3ENSG00000002549.81395.329301014.066100.460402.309701.40000K562EIF3A
LAP3ENSG00000002549.81275.057701744.53430-0.452303.257302.12820K562EIF3D
LAP3ENSG00000002549.81980.782401271.952300.6389011.9973010.32210K562EIF3G
LAP3ENSG00000002549.81032.526401322.56790-0.357202.844402.01160K562EIF4A3
LAP3ENSG00000002549.8836.131301191.08050-0.510506.387404.50290K562EIF4B
LAP3ENSG00000002549.81007.544201659.47560-0.719909.743508.09120K562FMR1
LAP3ENSG00000002549.8867.288001406.57110-0.697607.770606.15660K562FTO
LAP3ENSG00000002549.81763.573301375.421500.358504.815404.04710K562FXR1
LAP3ENSG00000002549.81701.636802037.33670-0.259802.646201.52940K562GLRX3
LAP3ENSG00000002549.8843.297401557.12770-0.8848014.8572012.98060K562GPKOW
LAP3ENSG00000002549.82584.779103528.85990-0.449203.084702.28950K562GRSF1
LAP3ENSG00000002549.8651.462301653.11300-1.3434020.3600018.82250K562HNRNPC
LAP3ENSG00000002549.81061.166401475.98760-0.476004.581803.06560K562HNRNPF
LAP3ENSG00000002549.81770.019902459.77910-0.474807.925706.41920K562HNRNPU
LAP3ENSG00000002549.8770.788401329.63250-0.786607.145205.56980K562KRR1
LAP3ENSG00000002549.81090.776701519.93680-0.478705.112703.90180K562METAP2
LAP3ENSG00000002549.82951.394703927.23430-0.412102.528701.45200K562MSI2
LAP3ENSG00000002549.81605.022502142.00190-0.416407.765706.47050K562MTPAP
LAP3ENSG00000002549.81803.788802379.91170-0.399909.868708.57600K562NSUN2
LAP3ENSG00000002549.81321.924501623.85210-0.296802.359801.46050K562PCBP2
LAP3ENSG00000002549.81644.297902199.18050-0.419503.430102.50300K562PCBP3
LAP3ENSG00000002549.81382.473801686.85830-0.287102.461601.70890K562POLR2G
LAP3ENSG00000002549.81169.282101482.12100-0.342002.735401.83730K562PSIP1
LAP3ENSG00000002549.83210.015804189.52650-0.384204.024302.86260K562PUM2
LAP3ENSG00000002549.81927.899001653.317200.221601.970901.45520K562RBM15
LAP3ENSG00000002549.81334.843201700.19740-0.349002.944302.07490K562RBM22
LAP3ENSG00000002549.82153.067501615.062900.414703.189202.31070K562RPS19
LAP3ENSG00000002549.81884.920501502.994300.326602.970701.85000K562SAFB
LAP3ENSG00000002549.81663.486302348.43200-0.497509.304307.87460K562SF3A3
LAP3ENSG00000002549.8780.720401480.93880-0.9236011.679909.59880K562SF3B1
LAP3ENSG00000002549.81041.526601324.90280-0.347203.308802.37290K562SF3B4
LAP3ENSG00000002549.81878.468002406.02530-0.357106.915305.51060K562SRPK2
LAP3ENSG00000002549.81314.627301738.35890-0.403104.314303.43520K562SRSF1
LAP3ENSG00000002549.81319.881502414.85500-0.871504.309902.37440K562SUPT6H
LAP3ENSG00000002549.8939.606501535.12390-0.708207.564905.82510K562SUPV3L1
LAP3ENSG00000002549.82327.443501691.946500.460006.442005.18130K562SYNCRIP
LAP3ENSG00000002549.81175.273301759.28810-0.582006.544105.41420K562TARDBP
LAP3ENSG00000002549.81316.303501697.04370-0.366503.777402.80050K562TIA1
LAP3ENSG00000002549.81069.086901275.51570-0.254701.998001.31590K562U2AF2
LAP3ENSG00000002549.81068.547901624.77470-0.604606.561004.92070K562UCHL5
LAP3ENSG00000002549.81602.315402523.47430-0.6553018.9746017.28130K562UPF1
LAP3ENSG00000002549.81669.961202357.68180-0.497606.717304.16520K562UPF2
LAP3ENSG00000002549.81190.152102159.25150-0.8594017.5774015.38190K562WDR3
LAP3ENSG00000002549.82591.673602245.410800.206802.779701.93180K562WDR43
LAP3ENSG00000002549.82852.859903473.28310-0.283902.797901.49780K562WRN
LAP3ENSG00000002549.81015.906402057.37060-1.018005.822803.25880K562XPO5
LAP3ENSG00000002549.82291.870103303.28580-0.527406.495805.08380K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for LAP3 is not available on ENCORE database.





3 RBPs can affect the splicing of LAP3 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SELAP3ENSG00000002549.8chr4+175814591758156217579048175791901758338217583775-0.077000.000080.00600excludedHepG2HNRNPU
SELAP3ENSG00000002549.8chr4+175839101758401617583382175834371758510517585265-0.053000.000060.00495excludedHepG2HNRNPU
MXELAP3ENSG00000002549.8chr4+1759866817598757176000781760018117597032175971571760621017606290-0.192000.000000.000062includedHepG2U2AF2
MXELAP3ENSG00000002549.8chr4+1759866817598757176000781760018117597032175971571760621017606290-0.152000.000410.018452includedHepG2RBFOX2

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for LAP3 is not avaliable on ENCORE database.