FTO

General Information

Gene Name       : FTO
Gene ID             : ENSG00000140718.20
Essential Gene : No

Functions

Localization

Domains (AlphaFold: FTO)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878FTOENSG00000140718.2038.2837.4537.87ENCSR000AEF
HepG2FTOENSG00000140718.2045.7053.7849.74ENCSR985KAT
K562FTOENSG00000140718.2015.8218.6317.23ENCSR000AEO

Assays

4 Released experiments are available on ENCORE database.

Assay TypeExp_NameENCODE IDTarget labelBiosampleStatusLinked AntibodyControlsMethodNote
eCLIPeCLIP: 464ENCSR989SMCFTOK562ReleasedENCAB377UYDENCSR575DKE  
eCLIPeCLIP: 723ENCSR903PRVFTOHepG2ReleasedENCAB377UYDENCSR343MKJ  
knockdown followed by RNA-seq FTO-BGKLV36-K562ENCSR688GVVFTOK562ReleasedENCSR424QCW   shRNAKD% = 86.4,84.6
knockdown followed by RNA-seq FTO-BGHLV35-HepG2ENCSR389HFUFTOHepG2ReleasedENCSR264TUE   shRNAKD% = 94.8,96.7






  eCLIP  
  RBP    Exp_UID    Cell_Line    ENCODE_ACCESSION    Control_ENCODE_ACCESSION    ENCODE_Antibody_ID    Antibody    Lot_num    Status    Project  
FTO464K562ENCSR989SMCENCSR575DKEENCAB377UYDRN121PW1ReleasedENCODE3
FTO723HepG2ENCSR903PRVENCSR343MKJENCAB377UYDRN121PW1ReleasedENCODE4


  Antibody Validation  
  GeneName    Antibody_DCC_ID    Product_ID    Lot_ID    Phosphate    HepG2 Primary Validation    K562 Primary Validation    HepG2 Secondary Validation    K562 Secondary Validation  
FTOENCAB377UYDRN121PW1Released, ENCODE3Released, ENCODE3BGHLV35-17, Released, ENCODE3BGKLV36-25, Released, ENCODE3


  KD RNA-Seq  
  GeneName    Cell_Line    Method    Exp_ID    Control_ID    Sample_reps    Control_reps    KD%    Status    Project    Note  
FTOK562shRNAENCSR688GVVENCSR424QCWFTO_BGKLV36-25,FTO_BGKLV36-26NT_BGKLV36-1,NT_BGKLV36-286.4,84.6ReleasedENCODE3
FTOHepG2shRNAENCSR389HFUENCSR264TUEFTO_BGHLV35-17,FTO_BGHLV35-18NT_BGHLV35-1,NT_BGHLV35-294.8,96.7ReleasedENCODE3
FTOHepG2shRNABGHLV35-19,BGHLV35-20BGHLV35-1,BGHLV35-291.5,91.7NotSatisfiedENCODE3


  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela
FTOProduct_ID: RN121PW
Lot_ID: 1
Source: MBLI
Target Name: FTO-human		 HepG2_MBLI_RN121PW_001_FTO.png<br>Caption: IP-Western Blot analysis of HepG2 whole cell lysate using FTO specific antibody. Lane 1 is 1% of twenty million whole cell lysate input and lane 2 is 25% of IP enrichment using rabbit normal IgG (lanes under 'IgG'). Lane 3 is 1% of twenty million whole cell lysate input and lane 4 is 10% IP enrichment using rabbit polyclonal anti-FTO antibody (lanes under 'FTO').
 FTO-HEPG2.png<br>Caption: Western blot following shRNA against FTO in HepG2 whole cell lysate using FTO specific antibody. Lane 1 is a ladder, lane 2 is HepG2 non-targeting control knockdown, lane 3 and 4 are two different shRNAs against FTO.FTO protein appears as the green arrow, GAPDH serves as a control and appears in red arrow.
 K562_MBLI_RN121PW_001_FTO.png<br>Caption: IP-Western Blot analysis of K562 whole cell lysate using FTO specific antibody. Lane 1 is 1% of twenty million whole cell lysate input and lane 2 is 10% of IP enrichment using rabbit normal IgG (lanes under 'IgG'). Lane 3 is 1% of twenty million whole cell lysate input and lane 4 is 10% IP enrichment using rabbit polyclonal anti-FTO antibody (lanes under 'FTO').
 FTO-K562.png<br>Caption: Western blot following shRNA against FTO in k562 whole cell lysate using FTO specific antibody. Lane 1 is a ladder, lane 2 is k562 non-targeting control knockdown, lane 3 and 4 are two different shRNAs against FTO.FTO protein appears as the green arrow, GAPDH serves as a control and appears in red arrow.








RNA Targets
  • FTO protein binds to 1,409 RNA regions.  





Proteins bound to RNA
  • FTO RNA is bound by 16 proteins.  






FTO protein has 1,409 RNA targets:

Only display 100 entries as example. Please click "View All" button to see all 1,409 entries.     

RBP Chr Start End Strand log2(fold change) -log(p-value) Cell Line Matched Gene Matched Area
FTOchr11205952206046-3.182514.70936K562BET1L3'-UTR,CDS,intron-Distal,intron-Proximal
FTOchr206062962360629696-3.143163.51264K562TAF4intron-Distal
FTOchr223574049735740563+4.533616.34679K562TOM1intron-Distal
FTOchr191854823318548293-4.290899.84307K562ISYNA1intron-Distal
FTOchr20307125307237+3.8985211.93416HepG2SOX12CDS
FTOchr1270373857037443+5.365097.61244K562ATN1intron-Distal
FTOchr1121531632153174-3.94921400.00000HepG2IGF23'-UTR,intron-Distal
FTOchr1121531402153152-4.01196400.00000HepG2IGF23'-UTR,intron-Distal
FTOchr45334553388+3.1018020.97827K562ZNF5955'-UTR,CDS,intron-Proximal
FTOchr1121524122152442-3.87870400.00000HepG2IGF23'-UTR,intron-Distal
FTOchr29755996097559989-5.9329281.56629K562FAM178Bintron-Distal
FTOchr2232327909232327956-3.9180228.38236HepG2NCLCDS,intron-Distal,intron-Proximal
FTOchr13114560222114560297-3.189723.51264K562GAS6intron-Distal
FTOchr3142838892142838996+3.340783.44887K562CHST25'-UTR
FTOchr412375651237610-4.848635.67080K562CTBP1intron-Distal
FTOchr84145581341455885+5.228136.64083K562AGPAT63'-UTR,5'-UTR
FTOchr173897507938975185-4.1917214.56065K562KRT10CDS,intron-Distal
FTOchr79773635397736441+3.422413.15824K562LMTK25'-UTR
FTOchr2120128312120128379+3.217794.43992HepG2DBICDS,intron-Proximal
FTOchr191735625917356378-3.837959.18233HepG2AC010646.3, NR2F65'-UTR,intron-Distal
FTOchr1270371177037188+3.375864.69669K562ATN1intron-Distal
FTOchr224999304149993107-3.707936.07223K562C22orf34intron-Distal
FTOchr718899311890018-4.678364.14689K562MAD1L1intron-Distal
FTOchr3195802167195802236-4.893045.44201HepG2TFRCCDS,intron-Distal,intron-Proximal
FTOchr223668275536682791-3.504486.82611HepG2MYH9CDS,intron-Distal,intron-Proximal
FTOchr1121529912153009-4.46545400.00000HepG2IGF23'-UTR,intron-Distal
FTOchr2201171379201171478+3.641795.00233HepG2SPATS2L5'-UTR,intron-Distal,intron-Proximal
FTOchr10120809338120809393-3.595834.57030HepG2EIF3ACDS,intron-Distal
FTOchr145036012550360217+3.919066.83645K562ARF65'-UTR
FTOchr167549843075498511-3.402095.86838K562RP11-77K12.1, TMEM170A5'-UTR,CDS,intron-Distal,intron-Proximal
FTOchr193913832139138457+3.213329.22976HepG2ACTN45'-UTR,CDS
FTOchr63466447934664564-4.1023624.77656K562C6orf1065'-UTR,intron-Distal
FTOchr161848059718480660-3.600563.44435HepG2RP11-1212A22.1, PKD1P5intron-Distal
FTOchr2037407273740830-4.935654.23238K562C20orf273'-UTR,CDS,intron-Distal,intron-Proximal
FTOchrX122994046122994122+3.156163.93266K562XIAP5'-UTR,intron-Distal
FTOchr25564670955646816-3.9774311.69009K562CCDC88A5'-UTR,intron-Distal,intron-Proximal
FTOchr7150066758150066826+3.293838.64106K562REPIN1, ZNF7755'-UTR,CDS,intron-Distal,intron-Proximal
FTOchr25419788154197940-4.6673527.85251K562PSME45'-UTR,CDS,intron-Distal,intron-Proximal
FTOchr25523485855234897-3.366893.10855K562RTN4intron-Distal
FTOchr10120809428120809500-3.255846.91729HepG2EIF3ACDS,intron-Distal,intron-Proximal
FTOchr194937611549376157+3.609613.10855K562PPP1R15Aintron-Distal
FTOchr11118926779118926805-3.2923910.99521K562HYOU15'-UTR,CDS,intron-Distal,intron-Proximal
FTOchr25419784254197940-3.910519.72149HepG2PSME45'-UTR,CDS,intron-Distal,intron-Proximal
FTOchr16448534448568+4.7746811.86047K562NME4intron-Distal
FTOchr11120081731120081825+3.342064.22169HepG2OAF5'-UTR
FTOchr2161349964161350043-3.585825.00827HepG2RBMS15'-UTR,intron-Distal,intron-Proximal
FTOchr19030044990300502+3.422413.15824K562RP11-302M6.4, LRRC8Dintron-Distal
FTOchr16447739447789+8.1842352.84394K562NME45'-UTR,intron-Distal,intron-Proximal
FTOchr1112233955112233985+3.267364.11552K562RAP1A3'-UTR,CDS,intron-Proximal
FTOchr142468758624687647-3.028684.50012HepG2NEDD8, NEDD8-MDP1CDS,intron-Distal,intron-Proximal
FTOchr19517214517320+4.533613.30242K562TPGS1intron-Distal
FTOchr194541181545411923+3.2202626.42243HepG2APOECDS
FTOchr726979192697926+3.201583.67487HepG2TTYH3CDS,intron-Proximal
FTOchr1180991825180991931-3.745414.29577K562STX65'-UTR,intron-Distal
FTOchr6167358316167358383-5.266444.57355K562RNASET2, AL133458.1, RP11-514O12.4intron-Distal
FTOchr157594049375940564+3.938924.94100K562SNX335'-UTR
FTOchr168566202885662077+4.848635.67080K562GSE1intron-Distal
FTOchr222011057920110657+6.235749.37513K562RANBP1intron-Distal
FTOchr202537119625371406-4.510277.07947HepG2ABHD125'-UTR,CDS,intron-Distal,intron-Proximal
FTOchr174612796946128062+3.2595014.96754K562NFE2L13'-UTR,5'-UTR
FTOchr1156713941156714062-3.668023.67487HepG2HDGFCDS,intron-Distal,intron-Proximal
FTOchr206233061562330665-3.507375.10573K562ARFRP13'-UTR,intron-Distal
FTOchr157619637776196438+4.214893.30242K562FBXO225'-UTR,CDS
FTOchr8126010842126010905+3.9074122.79795K562SQLE5'-UTR,CDS,intron-Proximal
FTOchr3128341110128341227-4.568014.02157HepG2RPN1CDS,intron-Distal
FTOchr1121531092153114-4.32632400.00000HepG2IGF23'-UTR,intron-Distal
FTOchr145316239253162477-4.079025.04492HepG2ERO1L5'-UTR,intron-Distal,intron-Proximal
FTOchr12132401661132401714+6.2443410.26108K562ULK1intron-Distal,intron-Proximal
FTOchr20306974307048+3.480836.53248HepG2SOX12CDS
FTOchr12111180511111180578-3.9893417.81009K562PPP1CC5'-UTR,CDS,intron-Distal
FTOchr225001563550015794-3.012987.74060K562C22orf34intron-Distal,intron-Proximal
FTOchr89878818798788248+3.395198.73667K562LAPTM4B5'-UTR,CDS
FTOchr1151162529151162604-3.678363.49944K562VPS725'-UTR,CDS,intron-Distal
FTOchr129625283596252855+3.269426.99831K562SNRPF5'-UTR,CDS,intron-Proximal
FTOchr203976624139766335+4.286546.38586HepG2PLCG15'-UTR,CDS
FTOchr167503295675033064+3.510276.53857HepG2ZNRF15'-UTR
FTOchr510981221098220-5.096614.14689K562SLC12A7intron-Distal
FTOchr177340156873401587-4.848638.19993K562GRB25'-UTR,intron-Distal,intron-Proximal
FTOchr1628063332806397+3.213279.90351HepG2SRRM23'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal
FTOchr9117051537117051562+4.010275.59033HepG2COL27A13'-UTR,CDS
FTOchr191854811018548186-3.366098.20908K562ISYNA15'-UTR,intron-Distal,intron-Proximal
FTOchr114411737044117403+3.385883.51264K562EXT25'-UTR,intron-Proximal
FTOchr191735663817356719-4.168836.14029HepG2NR2F6, AC010646.35'-UTR,intron-Distal
FTOchrX152953907152954014+3.6273319.76020HepG2SLC6A85'-UTR
FTOchr203053967330539776-3.042143.99208K562PDRG15'-UTR,CDS,intron-Distal
FTOchr29756006997560089-7.2519850.79237K562FAM178Bintron-Distal
FTOchr675812167581323+3.4512417.79951HepG2DSPCDS,intron-Distal
FTOchr1121528992152907-4.52773400.00000HepG2IGF23'-UTR,intron-Distal
FTOchr75613617456136257+3.250686.08453K562SUMF2CDS,intron-Distal,intron-Proximal
FTOchr16431924431976-3.132833.67487HepG2TMEM8A5'-UTR,intron-Distal
FTOchr111052989610529950-3.579023.47634HepG2MTRNR2L85'-UTR
FTOchr214688815746888234+3.019127.81302HepG2COL18A1CDS
FTOchr726779932678101+3.776646.82611HepG2TTYH3intron-Distal
FTOchr14102975804102975868-3.362543.97686HepG2ANKRD95'-UTR,intron-Distal
FTOchr214756474747564886-5.0533712.03553K562FTCDintron-Distal
FTOchr1121525292152539-3.44662400.00000HepG2IGF23'-UTR,intron-Distal
FTOchr8142425116142425172+3.871515.01751HepG2PTP4A3intron-Distal
FTOchr225002173250021794-3.017697.20785K562C22orf34intron-Distal
FTOchr68635266186352719-3.523514.48593HepG2SYNCRIP5'-UTR,intron-Distal,intron-Proximal
FTOchr1121522352152243-3.32131400.00000HepG2IGF23'-UTR,intron-Distal




16 proteins are bound to FTO RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr165396793153968082+3'-UTR,CDS,intron-Proximal3.8931412.28745HepG2BCLAF1
chr165396789553968038+3'-UTR,CDS,intron-Proximal3.348809.21862HepG2PPIG
chr165396789653968022+3'-UTR,CDS,intron-Proximal3.403463.50786HepG2G3BP1
chr165414606654146133+3'-UTR3.859005.33418K562FAM120A
chr165414602854146129+3'-UTR4.427599.82827HepG2UPF1
chr165414616754146269+3'-UTR4.302727.84191HepG2UPF1
chr165414710254147186+3'-UTR3.806393.08342HepG2AKAP1
chr165414632154146400+3'-UTR3.813385.40760HepG2UPF1
chr165414634354146394+3'-UTR4.510184.56348K562UPF1
chr165414616754146219+3'-UTR3.513833.88742K562FAM120A
chr165387806653878223+5'-UTR,CDS,intron-Proximal3.668136.23335HepG2GRWD1
chr165387806153878125+5'-UTR,CDS,intron-Proximal3.223453.05161HepG2PPIG
chr165392274353922870+5'-UTR,CDS,intron-Proximal3.819366.67313HepG2BCLAF1
chr165386016453860236+CDS,intron-Distal4.080343.68241HepG2G3BP1
chr165386029253860406+CDS,intron-Distal,intron-Proximal3.127125.14343HepG2PPIG
chr165386016753860256+CDS,intron-Distal3.885594.46864HepG2BCLAF1
chr165386028853860406+CDS,intron-Distal,intron-Proximal5.8614611.63584HepG2BCLAF1
chr165385998553860134+CDS,intron-Distal4.388684.42709HepG2G3BP1
chr165381004153810124+intron-Distal3.477383.11000HepG2HNRNPM
chr165377085653770919+intron-Distal4.153053.39864HepG2SUGP2
chr165405425154054316+intron-Distal4.595934.51080HepG2HNRNPL
chr165377061153770707+intron-Distal3.407456.72722HepG2SUGP2
chr165399007853990225+intron-Distal4.601835.89032HepG2QKI
chr165405758354057633+intron-Distal4.741535.83981HepG2RBFOX2
chr165409986454099979+intron-Distal5.6031410.44346HepG2QKI
chr165394263953942777+intron-Distal4.096463.27946HepG2HNRNPM
chr165376963353769672+intron-Distal3.724053.04224HepG2SUGP2
chr165405504754055141+intron-Distal4.253998.55014HepG2PTBP1
chr165405507454055136+intron-Distal4.428283.91475K562PTBP1
chr165405437754054439+intron-Distal3.828263.19026HepG2HNRNPL
chr165409202454092081+intron-Distal3.937633.64484HepG2HNRNPC
chr165377094153771002+intron-Distal3.499734.36650HepG2SUGP2
chr165376974953769817+intron-Distal4.173694.28663HepG2SUGP2
chr165400554854005659+intron-Distal3.220303.29213HepG2KHSRP
chr165379492253795063+intron-Distal4.248378.79903HepG2PTBP1
chr165377061253770697+intron-Distal4.411414.31720HepG2MATR3
chr165376973853769810+intron-Distal3.639244.28254HepG2MATR3
chr165374500053745057+intron-Distal3.727454.51074HepG2HNRNPL
chr165374139253741454+intron-Distal4.182983.78432HepG2MATR3
chr165406406754064116+intron-Distal4.442833.30440HepG2QKI
chr165377035653770437+intron-Distal4.482535.59955HepG2SUGP2
chr165381110353811165+intron-Distal4.626283.80778HepG2QKI
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




No autoregularoty interactions between protein FTO and its RNA.



Diffrential Expression
  • 6,844 differentially expressed genes after Knockdown/Knockout FTO protein.  





  • 53 RBPs can affect the levels of FTO.  







6,844 differentially expressed genes after Knockdown/Knockout FTO protein :

Only display 100 entries as example. Please click "View All" button to see all 6,844 entries.     

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
SCYL3ENSG00000000457.9245.56060120.935201.021703.283802.17480HepG2FTO
CYP51A1ENSG00000001630.117620.849604012.121000.925503.098902.02210HepG2FTO
CD99ENSG00000002586.131578.075302442.26340-0.630102.487101.52780HepG2FTO
LASP1ENSG00000002834.132580.098106499.45920-1.332909.612407.74890HepG2FTO
DBNDD1ENSG00000003249.9316.33690913.27770-1.529609.710507.83200HepG2FTO
ALS2ENSG00000003393.101809.762701071.843900.755602.867501.83320HepG2FTO
RBM5ENSG00000003756.123682.388202222.020700.728702.947701.89790HepG2FTO
PLXND1ENSG00000004399.81308.257402196.72950-0.747703.310402.19540HepG2FTO
RECQLENSG00000004700.11414.48230850.10380-1.036305.006403.64650HepG2FTO
UPF1ENSG00000005007.8807.097701234.67560-0.613302.251901.34510HepG2FTO
DHX33ENSG00000005100.8614.140001345.14710-1.131106.336704.80500HepG2FTO
LIG3ENSG00000005156.7439.110401008.05290-1.198906.604105.04030HepG2FTO
CREBBPENSG00000005339.81856.272302876.38360-0.631802.583101.60410HepG2FTO
ITGALENSG00000005844.13186.3193034.128602.4486010.804808.84030HepG2FTO
ZFXENSG00000005889.111136.76990583.069100.963104.612703.30800HepG2FTO
ASB4ENSG00000005981.877.86270250.39550-1.685207.160905.53510HepG2FTO
C19orf60ENSG00000006015.13131.2665063.868701.039202.424001.47890HepG2FTO
CRLF1ENSG00000006016.61437.774802722.57140-0.921104.768103.44290HepG2FTO
CX3CL1ENSG00000006210.62951.441801653.964700.835404.067302.83510HepG2FTO
ETV1ENSG00000006468.954.6664015.469301.821103.011201.95020HepG2FTO
ALDH3B1ENSG00000006534.1139.67900117.15450-1.562004.087802.85300HepG2FTO
GGCTENSG00000006625.13348.65590711.73610-1.029504.786703.45820HepG2FTO
DBF4ENSG00000006634.3418.95390968.88090-1.209506.764605.18230HepG2FTO
UPP2ENSG00000007001.861.406101.296805.565207.857906.15390HepG2FTO
PROM1ENSG00000007062.7258.11270466.29130-0.853203.101602.02370HepG2FTO
E2F2ENSG00000007968.677.92740185.41740-1.250603.895102.68960HepG2FTO
CYTH3ENSG00000008256.11107.81230314.09380-1.542705.682704.23110HepG2FTO
CYB561ENSG00000008283.1113.9180050.94390-1.872002.881701.84470HepG2FTO
MGST1ENSG00000008394.8999.450802124.02330-1.087606.156704.64340HepG2FTO
CRY1ENSG00000008405.7178.96140357.92500-1.000003.630102.46060HepG2FTO
NFIXENSG00000008441.12610.90490998.44300-0.708702.760001.74600HepG2FTO
PKD1ENSG00000008710.13861.22420492.324700.806702.423401.47860HepG2FTO
MED24ENSG00000008838.132177.432701450.323400.586202.202001.30460HepG2FTO
MLXIPLENSG00000009950.1113152.009503911.318001.7495015.8526013.56550HepG2FTO
NCAPD2ENSG00000010292.81351.055702630.96740-0.961505.185503.80050HepG2FTO
GIPRENSG00000010310.466.5355017.614301.917303.797802.60550HepG2FTO
LRRC23ENSG00000010626.1021.2895060.82640-1.514602.316501.39360HepG2FTO
FYNENSG00000010810.13301.50300868.51130-1.526409.633007.76820HepG2FTO
HIVEP2ENSG00000010818.41287.48170796.263400.693102.442801.49390HepG2FTO
CLCN6ENSG00000011021.172975.378401211.243501.296508.696706.91520HepG2FTO
PTBP1ENSG00000011304.123313.588605002.36660-0.594202.364401.43200HepG2FTO
ANLNENSG00000011426.6968.402603102.03500-1.6795013.8814011.70420HepG2FTO
QPCTLENSG00000011478.7112.78720243.77500-1.111903.616602.44900HepG2FTO
BRCA1ENSG00000012048.15621.420701469.33100-1.241507.525805.85790HepG2FTO
SEMA3BENSG00000012171.131214.057202099.37410-0.790103.570002.41000HepG2FTO
MBTPS2ENSG00000012174.71059.84910672.550800.656002.449901.49910HepG2FTO
EXTL3ENSG00000012232.4271.03860598.72390-1.143405.382603.97200HepG2FTO
NR1H4ENSG00000012504.91765.84390717.548201.299105.456904.03690HepG2FTO
CALCOCO1ENSG00000012822.111200.44720647.609900.890304.153802.91040HepG2FTO
UBR7ENSG00000012963.9285.25320586.89900-1.040904.563403.26770HepG2FTO
CLDN11ENSG00000013297.620.34860131.15090-2.688206.357704.82280HepG2FTO
CLK1ENSG00000013441.112059.05860888.380401.212603.236702.13440HepG2FTO
TACC3ENSG00000013810.14366.866901060.14220-1.5309010.111808.19690HepG2FTO
POLA2ENSG00000014138.4114.12700268.02110-1.231704.501803.21470HepG2FTO
MTMR11ENSG00000014914.15268.4227059.118702.1827011.387509.37290HepG2FTO
DPEP1ENSG00000015413.529.61440148.19720-2.323108.374106.62470HepG2FTO
CHDHENSG00000016391.62749.973301412.531600.961005.076503.71010HepG2FTO
WWTR1ENSG00000018408.101164.633002025.12870-0.798103.648302.47680HepG2FTO
SYT13ENSG00000019505.39.2271051.92840-2.492602.857201.82530HepG2FTO
CD74ENSG00000019582.103534.613002356.446600.584802.303001.38330HepG2FTO
MRE11AENSG00000020922.8295.83270543.46350-0.877403.439002.30280HepG2FTO
PLEKHB1ENSG00000021300.9623.008001915.84590-1.6207012.2637010.19060HepG2FTO
CYP3A43ENSG00000021461.1275.4786020.607401.872803.699202.51780HepG2FTO
SPASTENSG00000021574.7512.99020827.80580-0.690402.549201.57730HepG2FTO
C8BENSG00000021852.8249.8776085.778701.542406.203504.68520HepG2FTO
SLC45A4ENSG00000022567.531.663200.0000099999.999907.774006.07970HepG2FTO
GRAMD1BENSG00000023171.1031.508705.138102.616303.184002.09150HepG2FTO
DERAENSG00000023697.8285.71680512.69340-0.843503.114402.03440HepG2FTO
EHD2ENSG00000024422.7155.4424042.511601.870406.510404.96100HepG2FTO
DEPDC1ENSG00000024526.12230.55970605.65680-1.393407.607705.92540HepG2FTO
TYMPENSG00000025708.877.0899014.823702.378505.588004.14760HepG2FTO
TOMM34ENSG00000025772.7808.439601788.04790-1.145206.570405.01420HepG2FTO
RTEL1-TNFRSF6BENSG00000026036.16405.25620165.741501.289804.625203.31830HepG2FTO
AGPAT4ENSG00000026652.950.9550018.008001.500502.281201.36660HepG2FTO
MIPEPENSG00000027001.797.10330278.06260-1.517806.388804.85070HepG2FTO
IFNGR1ENSG00000027697.8746.606401525.96760-1.031305.383603.97200HepG2FTO
VRK2ENSG00000028116.12255.47070451.25930-0.820802.880101.84330HepG2FTO
SNX1ENSG00000028528.102788.065001824.777800.611402.393401.45590HepG2FTO
ARNTL2ENSG00000029153.10199.55430373.39430-0.903903.170902.08140HepG2FTO
HMGB3ENSG00000029993.10727.712501367.87300-0.910504.409803.13430HepG2FTO
RANBP3ENSG00000031823.10941.302801443.77290-0.617102.290601.37380HepG2FTO
TSSC1ENSG00000032389.8173.94890345.64570-0.990603.471102.32930HepG2FTO
FUT8ENSG00000033170.12185.23740674.65600-1.8648012.4581010.36630HepG2FTO
UHRF1ENSG00000034063.9618.483101918.88660-1.6335012.5785010.47480HepG2FTO
TMSB10ENSG00000034510.42280.927104298.61780-0.914302.616701.63010HepG2FTO
VCLENSG00000035403.12958.841301620.26180-0.756903.228202.12760HepG2FTO
DEPDC1BENSG00000035499.8259.98190510.18880-0.972603.945202.72950HepG2FTO
NSMAFENSG00000035681.3530.83780829.78230-0.644502.327701.40300HepG2FTO
USP2ENSG00000036672.11126.08590464.18990-1.8803011.177009.16820HepG2FTO
RPL26L1ENSG00000037241.3137.94250274.65860-0.993603.199602.10520HepG2FTO
VCANENSG00000038427.111153.945904164.83810-1.851704.247102.99230HepG2FTO
CDH1ENSG00000039068.144599.71050720.033902.6753032.3610029.40000HepG2FTO
PHLPP2ENSG00000040199.14907.15110542.537700.741502.896101.85550HepG2FTO
SPDL1ENSG00000040275.12326.42660609.70630-0.901403.669102.49420HepG2FTO
PARP3ENSG00000041880.101018.57340541.328000.911904.224702.97150HepG2FTO
ADAM28ENSG00000042980.815.399800.848204.182302.669201.67130HepG2FTO
ZIC2ENSG00000043355.6101.8203020.755102.294404.868903.52820HepG2FTO
PHKA2ENSG00000044446.73170.446501578.356401.006205.496604.07050HepG2FTO
FAM214AENSG00000047346.8493.13240293.766600.747202.576301.59890HepG2FTO
COL9A2ENSG00000049089.9523.226101416.96730-1.437309.461907.61340HepG2FTO
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





53 RBPs can affect the gene expression of FTO :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
FTOENSG00000140718.141042.72970796.423400.388702.978801.87190HepG2AATF
FTOENSG00000140718.142091.941901364.882500.616005.667504.93790HepG2AKAP1
FTOENSG00000140718.14641.17190977.09690-0.607804.182003.03190HepG2BCCIP
FTOENSG00000140718.14958.629501211.21180-0.337402.476801.90720HepG2BOP1
FTOENSG00000140718.141715.91800800.168901.1005010.644709.17570HepG2CNOT7
FTOENSG00000140718.14877.351601111.95930-0.341902.387101.74180HepG2CPSF6
FTOENSG00000140718.14641.95710898.92990-0.485702.558401.31950HepG2DDX27
FTOENSG00000140718.14662.39560960.66210-0.536303.360302.51880HepG2DDX55
FTOENSG00000140718.14866.248101123.09780-0.374602.222401.66300HepG2DDX6
FTOENSG00000140718.14799.490301006.96270-0.332903.148902.40310HepG2DNAJC21
FTOENSG00000140718.14766.38090998.11990-0.381205.002804.16690HepG2DNAJC2
FTOENSG00000140718.14819.259801079.71180-0.398302.678602.09550HepG2EIF2S1
FTOENSG00000140718.141078.568501298.46850-0.267702.477501.67700HepG2EIF4G1
FTOENSG00000140718.14984.906201243.84700-0.336802.391501.63180HepG2EIF4G2
FTOENSG00000140718.141049.79070837.461500.325902.373001.31100HepG2FASTKD2
FTOENSG00000140718.141918.502501334.718200.523304.459703.49930HepG2FIP1L1
FTOENSG00000140718.14301.682601113.86330-1.8845014.7031012.48080HepG2FTO
FTOENSG00000140718.14823.596801260.49490-0.614005.442804.56490HepG2GPKOW
FTOENSG00000140718.14712.552901016.61020-0.512704.900904.07400HepG2HNRNPA1
FTOENSG00000140718.14849.781801130.80710-0.412203.365102.60680HepG2HNRNPC
FTOENSG00000140718.14900.088801130.75440-0.329102.183001.55740HepG2HNRNPK
FTOENSG00000140718.14959.640901202.91330-0.326002.070101.51740HepG2HNRNPLL
FTOENSG00000140718.14662.305401135.20090-0.777408.596307.47770HepG2IGF2BP2
FTOENSG00000140718.14858.944501141.79220-0.410702.209601.32620HepG2KHSRP
FTOENSG00000140718.14947.569101211.02010-0.353902.059001.50870HepG2MATR3
FTOENSG00000140718.14752.848701001.91750-0.412304.461903.54570HepG2PPIL4
FTOENSG00000140718.141051.702701321.53000-0.329502.991202.29340HepG2PUM2
FTOENSG00000140718.141405.155801159.604800.277002.406401.81750HepG2QKI
FTOENSG00000140718.14833.804801121.72160-0.427902.135301.30450HepG2RPS10
FTOENSG00000140718.14631.032901029.23870-0.705807.827406.52540HepG2RPS2
FTOENSG00000140718.14826.761701050.66170-0.345802.397801.40180HepG2RPS5
FTOENSG00000140718.14906.944401190.64790-0.392703.123102.37500HepG2SF3B1
FTOENSG00000140718.141027.063701194.55960-0.218002.058401.43650HepG2SLBP
FTOENSG00000140718.14878.180201166.57870-0.409706.225405.32060HepG2SMN1
FTOENSG00000140718.14898.123001230.07340-0.453806.313205.42100HepG2SRSF5
FTOENSG00000140718.14923.352301151.93520-0.319103.528202.75550HepG2SRSF7
FTOENSG00000140718.14449.82570956.36720-1.0882012.0367010.79190HepG2SUPV3L1
FTOENSG00000140718.14521.399301091.46370-1.0658021.2921020.14570HepG2TIAL1
FTOENSG00000140718.14502.559901101.28610-1.1318030.8093029.17550HepG2TRIM56
FTOENSG00000140718.14353.91400564.98480-0.674805.070504.03600HepG2UCHL5
FTOENSG00000140718.14534.32550875.85230-0.713004.512103.21220HepG2UPF2
FTOENSG00000140718.14978.000801197.66970-0.292302.969302.35280HepG2UTP3
FTOENSG00000140718.14612.82590941.43730-0.619404.868003.91450HepG2XRN2
FTOENSG00000140718.14972.027001364.33010-0.489109.564108.70210HepG2ZNF622
FTOENSG00000140718.14719.70610580.726500.309402.403501.79030K562DDX47
FTOENSG00000140718.14192.62530275.79020-0.517802.908501.71830K562EIF4B
FTOENSG00000140718.14536.86500704.44840-0.391902.757701.82130K562EIF4G2
FTOENSG00000140718.14337.23310524.09210-0.636105.016603.84960K562FIP1L1
FTOENSG00000140718.14119.34770413.19180-1.7916021.3773018.70060K562FTO
FTOENSG00000140718.14520.45940710.59030-0.449203.304202.43710K562HSPD1
FTOENSG00000140718.14239.78520380.69090-0.666905.148103.84130K562MATR3
FTOENSG00000140718.14186.83580284.78200-0.608102.833301.51930K562NONO
FTOENSG00000140718.14406.73610594.91450-0.548604.147103.11590K562PPIG
FTOENSG00000140718.14387.44810542.36030-0.485203.265001.51390K562RBM17
FTOENSG00000140718.14262.22970355.38600-0.438602.324901.55940K562RBM22
FTOENSG00000140718.14191.75970434.07110-1.178606.008303.75790K562SFPQ
FTOENSG00000140718.14244.90440367.70940-0.586303.545802.74140K562TARDBP
FTOENSG00000140718.14200.91800314.56740-0.646803.388402.34830K562TIAL1
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





1,388 alternative splicing events after Knockdown/Knockout FTO protein :

Only display 100 entries as example. Please click "View All" button to see all 1,388 entries.     

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SECCDC41ENSG00000173588.10chr12-9472198094722084947066899470679394725475947256050.151000.000050.01486includedK562FTO
SESNRNP70ENSG00000104852.10chr19+4960537049606844496046464960472849607890496079920.234000.000000.00000includedK562FTO
SETMEM59ENSG00000116209.7chr1-5451293954513045545090455450919854518672545188650.238000.000150.03629includedK562FTO
SEASCC2ENSG00000100325.10chr22-3022346530223589302216823022176930228233302283310.064000.000040.01173includedK562FTO
SENSUN6ENSG00000241058.1chr10-1893249718932569189314041893148418937418189375740.107000.000000.00026includedK562FTO
SETMEM50BENSG00000142188.12chr21-3482831034828404348280333482809134832719348328280.071000.000000.00000includedK562FTO
SEDNAH14ENSG00000185842.10chr1+2251478542251480042251426602251428002251521802251523110.166000.000020.00779includedK562FTO
SEDIAPH1ENSG00000131504.11chr5-1409677901409678171409666081409667641409983641409986220.292000.000310.06354includedK562FTO
SEALDOAENSG00000149925.12chr16+3007719630077248300757443007582630078554300786870.112000.000000.00043includedK562FTO
SEPI4KAP2ENSG00000183506.12chr22-2183093221831053218302802183044921832078218322040.172000.000430.07843includedK562FTO
SEPSMD6ENSG00000163636.6chr3-6400841464008477640079936400819964008950640091320.055000.000560.09360includedK562FTO
SETNNT1ENSG00000105048.12chr19-5565780155657834556569115565693355658048556580750.139000.000340.06641includedK562FTO
SECOPZ1ENSG00000111481.5chr12+5473433054734399547189105471896554735989547360710.059000.000040.01192includedK562FTO
SESREK1ENSG00000153914.11chr5+6545189265454760654492906544942465455046654551620.309000.000000.00000includedK562FTO
SEEXO1ENSG00000174371.12chr1+2420298862420300332420247072420248042420301312420303570.069000.000140.03398includedK562FTO
SERP11-43F13.1ENSG00000188002.6chr5-1600432160063715990341599942160280516028500.244000.000000.00095includedK562FTO
SENDUFV3ENSG00000160194.13chr21+4432329144324386443170364431715744328973443292150.145000.000010.00475includedK562FTO
SERHOT1ENSG00000126858.12chr17+3049995530500079304980613049812030500849305009310.117000.000000.00019includedK562FTO
SEDCAF6ENSG00000143164.11chr1+1679922251679922851679737701679740311680076081680077260.231000.000000.00018includedK562FTO
SECOPS4ENSG00000138663.4chr4+8399435883994506839895908398967583996449839969090.096000.000040.01360includedK562FTO
SEHBE1ENSG00000213931.1chr11-5299578529966652910285291386530313853031810.119000.000470.08349includedK562FTO
SEOCRLENSG00000122126.11chrX+1286918371286919271286913011286914121286926091286927300.122000.000190.04283includedK562FTO
SENSFL1CENSG00000088833.13chr20-1426639142679414263101426475143313714332750.160000.000000.00001includedK562FTO
SEC14orf159ENSG00000133943.16chr14+9161156491611657915807449158087291623982916240340.294000.000000.00198includedK562FTO
SENAPGENSG00000134265.8chr18+1053076610530834105260301052615510539758105398680.367000.000000.00198includedK562FTO
SEHMGN1ENSG00000205581.6chr21-4071775540719218407170644071720040719304407194090.174000.000070.01890includedK562FTO
SELETMD1ENSG00000050426.11chr12+5144587451445990514428165144296851450132514501740.219000.000010.00238includedK562FTO
SELPGAT1ENSG00000123684.8chr1-2119609732119610692119565702119568442119664132119665320.110000.000150.03639includedK562FTO
SEHNRNPDENSG00000138668.14chr4-8327604783276154832749868327530783276456832765540.072000.000000.00001includedK562FTO
SESNHG16ENSG00000163597.10chr17+7455502674555125745538737455393974557369745574800.210000.000010.00383includedK562FTO
SECD47ENSG00000196776.10chr3-1077707851077708171077621451077661391077763231077764160.248000.000160.03898includedK562FTO
SEC12orf65ENSG00000130921.3chr12+1237182861237184711237180081237180781237381931237385110.089000.000420.07731includedK562FTO
SENVLENSG00000143748.13chr1-2244547052244549252244379132244380202244557352244558350.281000.000590.09675includedK562FTO
SEALDH2ENSG00000111275.8chr12+1122134081122135241122047511122049001122197211122198260.169000.000310.06361includedK562FTO
SELMBR1ENSG00000105983.15chr7-1564807231564808851564756841564768571565168051565168720.084000.000500.08631includedK562FTO
SEMAPRE3ENSG00000084764.6chr2+2724696327247165272461992724634527248450272486050.069000.000010.00371includedK562FTO
SEZRANB2ENSG00000132485.8chr1-7153136071531431715307367153082071532458715328890.179000.000030.01000includedK562FTO
SECIB2ENSG00000136425.8chr15-7841604678416081784035067840361878423506784235770.169000.000040.01188includedK562FTO
SEHNRNPDLENSG00000152795.13chr4-8334671583346820833457818334603683347189833472820.141000.000000.00000includedK562FTO
SEDYRK1AENSG00000157540.15chr21+3880257038802702387926263879268638844985388450170.150000.000500.08631includedK562FTO
SEGLTSCR1LENSG00000112624.8chr6+4277804342778139427497644274983942789755427898010.393000.000500.08631includedK562FTO
SEZNF586ENSG00000083828.11chr19+5828791058288037582810375828124658290118582919820.499000.000260.05842includedK562FTO
SECEP44ENSG00000164118.8chr4+1752191161752192131752048271752050941752202221752203610.455000.000170.04068includedK562FTO
SEARPC4-TTLL3ENSG00000250151.5chr3+9870183987025998686809868924987064398710790.121000.000160.03894includedK562FTO
SENUPL2ENSG00000136243.12chr7+2323679123236866232362982323638523239076232391610.167000.000040.01173includedK562FTO
SEPHKBENSG00000102893.11chr16+4766780947667892476447364764483147674945476750010.295000.000520.08863includedK562FTO
SEBCAP29ENSG00000075790.6chr7+1072540981072541771072537761072538771072587721072591090.291000.000010.00332includedK562FTO
SETFPIENSG00000003436.10chr2-1883940901883942121883683741883684971884189261884190760.132000.000000.00000includedK562FTO
SECD46ENSG00000117335.14chr1+2079635972079636902079589632079590272079668632079688580.151000.000040.01189includedK562FTO
SEZCCHC9ENSG00000131732.7chr5+8060055980600960805974308059751780604379806044710.121000.000280.05992includedK562FTO
SEUQCRHENSG00000173660.7chr1+4677556846775716467747724677479946775826467759880.161000.000000.00001includedK562FTO
SESMAD2ENSG00000175387.11chr18-4539442245394468453914294539150445394693453948280.219000.000000.00063includedK562FTO
SEGAS5ENSG00000234741.3chr1-1738346471738346851738343661738344201738358981738359340.060000.000000.00010includedK562FTO
SERFC5ENSG00000111445.9chr12+1184554941184556201184545051184546971184568761184569410.059000.000000.00107includedK562FTO
SENFATC3ENSG00000072736.14chr16+6812725868127362681192686811968768155889681570240.070000.000440.07990includedK562FTO
SEHMGN3ENSG00000118418.10chr6-7991177279911872799109617991144379911992799121060.096000.000000.00000includedK562FTO
SETFAMENSG00000108064.6chr10+6015052460150620601484296014857960154117601541740.110000.000210.04742includedK562FTO
SETMEM209ENSG00000146842.12chr7-1298182411298183671298153511298154491298214621298215590.084000.000310.06361includedK562FTO
SETEKT4P2ENSG00000188681.7chr21-9916318991654799090469909277996632199663800.185000.000220.04946includedK562FTO
SEEIF3MENSG00000149100.8chr11+3260855732608690326053773260547532611092326111870.189000.000450.08069includedK562FTO
SEKCTD9ENSG00000104756.11chr8-2530364425303766252980922529818925315714253159580.388000.000020.00779includedK562FTO
SESF3A3ENSG00000183431.7chr1-3844439138444499384352423843540738445136384452050.523000.000040.01188includedK562FTO
SETXNL4AENSG00000141759.10chr18-7773759777737701777328747773385677748239777485930.119000.000000.00001includedK562FTO
SEMDN1ENSG00000112159.7chr6-9037796690378162903777329037787090380637903807990.120000.000010.00464includedK562FTO
SEIP6K2ENSG00000068745.10chr3-4875282148752960487314834873285148754589487546470.252000.000460.08187includedK562FTO
SERPL17ENSG00000265681.2chr18-4701810547018203470178864701795447018644470187690.248000.000000.00001includedK562FTO
SESRRM1ENSG00000133226.12chr1+2498967324989715249891502498929524993305249934160.100000.000310.06361includedK562FTO
SESRRM1ENSG00000133226.12chr1+2497356924973699249731042497328024975349249755200.352000.000000.00000includedK562FTO
SEEZH2ENSG00000106462.6chr7-1485160691485161511485137751485152091485166871485168040.066000.000000.00000includedK562FTO
SEFAM192AENSG00000172775.12chr16-5720853157208600572076395720778157219732572199340.227000.000040.01369includedK562FTO
SEITGB1BP1ENSG00000119185.8chr2-9547577954772795464779547034954824195483340.104000.000590.09644includedK562FTO
SEUBXN2BENSG00000215114.3chr8+5932585759325930593239175932402859329408593295120.342000.000120.02972includedK562FTO
SEPPFIA1ENSG00000131626.11chr11+7019602870196145701942947019452670200406702005580.116000.000340.06729includedK562FTO
SESRSF3ENSG00000112081.12chr6+3656759736568053365665843656676036568928365689670.081000.000380.07299includedK562FTO
SEEIF4G3ENSG00000075151.15chr1-2126775121267888212313752123146421267983212681110.080000.000000.00081includedK562FTO
SESRSF11ENSG00000116754.9chr1+7069754170697658706941217069423870697950706980580.189000.000000.00009includedK562FTO
SEBCLAF1ENSG00000029363.11chr6-1365881761365883131365824021365826151365892991365894110.144000.000620.09968includedK562FTO
SEPARLENSG00000175193.8chr3-1835515111835516131835512791835513771835583571835584280.227000.000100.02626includedK562FTO
SECOA4ENSG00000181924.6chr11-7358752373587620735840417358443973587801735878880.133000.000270.05930includedK562FTO
SEEIF2B3ENSG00000070785.12chr1-4536302645363107453472834534741145392299453923270.085000.000410.07731includedK562FTO
SEATAD3AENSG00000197785.9chr1+1462540146261814618401461911146307414632420.061000.000610.09927includedK562FTO
SETIAL1ENSG00000151923.13chr10-1213363581213364171213361221213362621213365911213367260.149000.000000.00000includedK562FTO
SEASCC1ENSG00000138303.13chr10-7391262673912746738928147389293973921295739214320.118000.000330.06504includedK562FTO
SEMPHOSPH8ENSG00000196199.9chr13+2024497920245104202443752024450320245345202454290.639000.000000.00150includedK562FTO
SESRSF7ENSG00000115875.14chr2-3897603938976488389757203897579538976670389768470.090000.000030.01000includedK562FTO
SESTRBPENSG00000165209.14chr9-1259018071259019661258986591258987941259091331259093330.059000.000390.07499includedK562FTO
SEFRG1BENSG00000149531.10chr20+2962913229629179296282262962833129631537296316290.119000.000070.01977includedK562FTO
SERPS24ENSG00000138326.14chr10+7979996179799983797969517979706279800372798004550.162000.000000.00000includedK562FTO
SEZC3H14ENSG00000100722.14chr14+8906307789063152890443288904448489068267890684270.132000.000000.00222includedK562FTO
SELRRFIP2ENSG00000093167.13chr3-3713295737133029371251263712529737136282371363990.241000.000000.00012includedK562FTO
SEUBE4AENSG00000110344.5chr11+1182527291182529131182521051182522381182533031182534910.055000.000170.03913includedK562FTO
SEPOLDIP3ENSG00000100227.13chr22-4299367842993743429921914299237142995703429957990.060000.000500.08631includedK562FTO
SEZNF681ENSG00000196172.8chr19-2393762423937699239261592392812523941548239416390.361000.000480.08534includedK562FTO
SECREMENSG00000095794.15chr10+3542670935426807354159163541612135437295354374190.067000.000020.00721includedK562FTO
SESPAG9ENSG00000008294.16chr17-4914529249145373491337724913384349156944491570650.079000.000190.04283includedK562FTO
SEFAM193BENSG00000146067.11chr5-176950159176950266176948974176949072176950957176951033-0.191000.000300.06346excludedK562FTO
SEFAM3AENSG00000071889.12chrX-153736141153736192153735736153735821153736619153736678-0.311000.000300.06248excludedK562FTO
SEDEPDC1ENSG00000024526.12chr1-689477286894858068947122689472956894963268949773-0.171000.000000.00000excludedK562FTO
SERANENSG00000132341.7chr12+131357128131357174131356626131356671131357380131357465-0.067000.000020.00792excludedK562FTO
SEYBX1ENSG00000065978.13chr1+431618694316194143159160431591944316231243162615-0.105000.000000.00000excludedK562FTO






No RBPs affect the alternative splcing events of FTO on ENCORE database.





No autoregularoty alternative splicing events between protein FTO and its RNA.