TMEM50B

General Information

Gene Name       : TMEM50B
Gene ID             : ENSG00000142188.16
Essential Gene : No

Functions

Localization

Domains (AlphaFold: TMEM50B)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878TMEM50BENSG00000142188.1613.069.4011.23ENCSR000AEF
HepG2TMEM50BENSG00000142188.1614.8223.6619.24ENCSR985KAT
K562TMEM50BENSG00000142188.1616.8119.3818.09ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for TMEM50B is not avaliable on ENCORE database.



Proteins bound to RNA
  • TMEM50B RNA is bound by 24 proteins.  







eCLIP assay for TMEM50B is not avaliable on ENCORE database.





24 proteins are bound to TMEM50B RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr213482310834823189-3'-UTR,CDS,intron-Distal,intron-Proximal3.348449.91056K562U2AF2
chr213482112834821203-3'-UTR,intron-Distal,intron-Proximal3.784787.40091HepG2U2AF2
chr213482311334823171-3'-UTR,CDS,intron-Distal,intron-Proximal3.2712311.89551K562DDX24
chr213482171734821761-3'-UTR,intron-Distal,intron-Proximal3.074207.83941K562U2AF2
chr213480500934805067-3'-UTR,intron-Distal,intron-Proximal3.347413.05161HepG2PPIG
chr213480507034805110-3'-UTR,intron-Distal,intron-Proximal3.665894.77549HepG2PABPN1
chr213482162834821734-3'-UTR,intron-Distal,intron-Proximal4.6064113.46677K562DGCR8
chr213482252034822572-3'-UTR,intron-Distal3.569535.34807K562ILF3
chr213482301434823084-3'-UTR,intron-Distal5.4643517.80807K562TIA1
chr213482119434821218-3'-UTR,intron-Distal,intron-Proximal3.395249.64430K562SF3B4
chr213482140934821437-3'-UTR,intron-Distal,intron-Proximal3.005233.87162K562KHSRP
chr213482169234821791-3'-UTR,intron-Distal,intron-Proximal4.161854.98079K562HNRNPC
chr213480489834805074-3'-UTR,intron-Distal,intron-Proximal4.811107.48353HepG2LSM11
chr213482802234828058-3'-UTR,CDS,intron-Distal,intron-Proximal4.337876.45252K562PRPF8
chr213482135334821386-3'-UTR,intron-Distal,intron-Proximal3.026015.33344K562KHSRP
chr213480500934805068-3'-UTR,intron-Distal,intron-Proximal4.850855.87202K562UCHL5
chr213482310534823170-3'-UTR,CDS,intron-Distal4.316386.08299HepG2PPIG
chr213482803234828083-3'-UTR,CDS,intron-Distal,intron-Proximal4.316383.20743HepG2PPIG
chr213482252434822586-3'-UTR,intron-Distal4.350253.53569K562LIN28B
chr213482314334823221-3'-UTR,CDS,intron-Distal,intron-Proximal4.057079.47061K562SF3B4
chr213484104834841206-3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal3.061458.81110K562BUD13
chr213482114434821205-3'-UTR,intron-Distal,intron-Proximal3.466454.71876K562U2AF1
chr213482114234821202-3'-UTR,intron-Distal,intron-Proximal4.0192615.54693K562U2AF2
chr213482803334828048-3'-UTR,CDS,intron-Distal,intron-Proximal3.065916.75313K562DDX24
chr213482132434821353-3'-UTR,intron-Distal,intron-Proximal3.437547.68575K562KHSRP
chr213480500934805052-3'-UTR,intron-Distal,intron-Proximal3.204876.36421K562ZNF622
chr213485214434852273-5'-UTR,intron-Distal,intron-Proximal5.5089518.21641HepG2DDX3X
chr213485214234852196-5'-UTR,intron-Distal4.995379.67018K562DDX3X
chr213485219634852267-5'-UTR,intron-Distal,intron-Proximal4.013633.08493K562DDX3X
chr213483274334832807-5'-UTR,CDS,intron-Distal4.107737.39805K562DDX24
chr213483273734832813-5'-UTR,CDS,intron-Distal,intron-Proximal4.663954.38106HepG2PPIG
chr213485214534852206-5'-UTR,intron-Distal3.213115.44868K562ZNF622
chr213484104034841096-CDS,intron-Distal,intron-Proximal4.252739.78712K562AQR
chr213483935534839410-CDS,intron-Distal3.153333.14203K562LIN28B
chr213484106834841152-CDS,intron-Distal,intron-Proximal3.147445.21025HepG2PPIG
chr213482835434828415-CDS,intron-Distal,intron-Proximal3.828597.05584K562U2AF2
chr213484105234841122-CDS,intron-Distal,intron-Proximal4.286764.16174HepG2PRPF8
chr213483335434833415-intron-Distal4.435444.48529K562TIA1
chr213482788334828020-intron-Distal,intron-Proximal4.195566.40042K562EFTUD2
chr213481993934820013-intron-Distal4.463803.87294K562TARDBP
chr213483262734832665-intron-Distal,intron-Proximal3.369823.37074K562TIA1
chr213485186934851958-intron-Distal4.170413.30664K562NONO
chr213482466934824784-intron-Distal3.769346.75305K562MATR3
chr213482698034827007-intron-Distal5.559075.34095K562TROVE2
chr213482489934824957-intron-Distal4.033085.97215K562MATR3
chr213482815134828204-intron-Distal,intron-Proximal3.707307.02852K562KHSRP
chr213482795734828022-intron-Distal,intron-Proximal5.7574110.77996K562PRPF8
chr213480926234809300-intron-Distal,intron-Proximal3.970443.20743HepG2PPIG
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for TMEM50B is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for TMEM50B is not available on ENCORE database.

  • 107 RBPs can affect the levels of TMEM50B.  








The Knockdown/knockout RNA-Seq assay for TMEM50B is not available on ENCORE database.





107 RBPs can affect the gene expression of TMEM50B :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
TMEM50BENSG00000142188.12979.46890591.541400.727405.559403.20710HepG2AARS
TMEM50BENSG00000142188.12725.51760417.287400.797908.594906.82770HepG2AATF
TMEM50BENSG00000142188.121086.17940733.738000.565808.820607.70860HepG2AUH
TMEM50BENSG00000142188.12478.68750721.72510-0.592404.564403.81840HepG2BOP1
TMEM50BENSG00000142188.121284.96180611.129801.0721022.5441020.74580HepG2CALR
TMEM50BENSG00000142188.12986.68380717.447400.459602.660201.70780HepG2CCAR1
TMEM50BENSG00000142188.12550.35360412.406100.416202.325301.61110HepG2CIRBP
TMEM50BENSG00000142188.12428.91080531.72490-0.310002.268001.65680HepG2CKAP4
TMEM50BENSG00000142188.12483.72180662.59830-0.454002.936902.23120HepG2CPSF6
TMEM50BENSG00000142188.12666.60220450.522000.565105.027203.78820HepG2DDX24
TMEM50BENSG00000142188.121217.17750502.570701.2760020.0885018.56750HepG2DDX3X
TMEM50BENSG00000142188.12361.70700467.87580-0.371302.884202.22060HepG2DNAJC2
TMEM50BENSG00000142188.12519.55940339.836900.612304.038302.95880HepG2EIF3D
TMEM50BENSG00000142188.12708.15660458.690800.626402.786202.14490HepG2EIF4A3
TMEM50BENSG00000142188.12746.43100446.523000.741205.002704.09680HepG2EIF4B
TMEM50BENSG00000142188.12717.47090903.22900-0.332203.420902.50540HepG2EIF4G1
TMEM50BENSG00000142188.121172.47080842.365100.476906.817605.94330HepG2ETF1
TMEM50BENSG00000142188.12687.68530519.701700.404002.974702.11160HepG2EWSR1
TMEM50BENSG00000142188.121018.03600624.520800.704905.656504.59440HepG2FIP1L1
TMEM50BENSG00000142188.12483.18100268.230700.849007.826806.53980HepG2FUBP3
TMEM50BENSG00000142188.12869.08170580.905400.581103.533102.26970HepG2FUS
TMEM50BENSG00000142188.12678.09570462.677900.551403.960003.14210HepG2FXR1
TMEM50BENSG00000142188.12818.99850429.265700.931909.962208.73790HepG2G3BP1
TMEM50BENSG00000142188.12612.99520455.636800.427902.517501.66970HepG2G3BP2
TMEM50BENSG00000142188.12449.20090302.584800.569903.680402.63370HepG2GEMIN5
TMEM50BENSG00000142188.12489.16000751.14910-0.618804.530203.72400HepG2GPKOW
TMEM50BENSG00000142188.12468.48840655.40270-0.484405.200204.25480HepG2HNRNPF
TMEM50BENSG00000142188.12649.10910434.520700.578903.382402.61250HepG2HNRNPK
TMEM50BENSG00000142188.12564.27580834.19050-0.564007.292006.24450HepG2HNRNPL
TMEM50BENSG00000142188.12568.88720430.844200.400902.502601.59510HepG2HNRNPM
TMEM50BENSG00000142188.12466.96540645.37930-0.466804.041603.18070HepG2IGF2BP1
TMEM50BENSG00000142188.12619.45170436.362000.505403.307702.57520HepG2IGF2BP2
TMEM50BENSG00000142188.12975.24800409.415001.252105.166503.84180HepG2IGF2BP3
TMEM50BENSG00000142188.12424.81580537.92770-0.340602.598301.88590HepG2ILF2
TMEM50BENSG00000142188.12651.66130438.863000.570303.352802.23710HepG2KHSRP
TMEM50BENSG00000142188.12340.98840486.16420-0.511704.863803.51850HepG2KIF1C
TMEM50BENSG00000142188.12872.96090545.244500.678904.654903.02800HepG2KRR1
TMEM50BENSG00000142188.12639.75290462.838900.466902.857102.19190HepG2MAGOH
TMEM50BENSG00000142188.12524.37510355.679400.559902.483101.48370HepG2METAP2
TMEM50BENSG00000142188.12665.60480476.429200.482302.987902.33080HepG2NCBP2
TMEM50BENSG00000142188.12569.69080424.365400.424802.413301.73540HepG2PABPC4
TMEM50BENSG00000142188.12347.67790521.28110-0.584305.667804.51530HepG2PARN
TMEM50BENSG00000142188.12540.20440430.110000.328701.982901.45520HepG2PCBP1
TMEM50BENSG00000142188.12649.29870437.646400.569005.974505.23300HepG2PTBP1
TMEM50BENSG00000142188.12661.43290866.70830-0.390003.255302.61560HepG2PUF60
TMEM50BENSG00000142188.12755.20530919.98680-0.284702.679102.09330HepG2PUM1
TMEM50BENSG00000142188.12917.43730473.995900.9526015.5856014.27750HepG2QKI
TMEM50BENSG00000142188.121021.82530704.074800.537206.765506.04040HepG2RBM22
TMEM50BENSG00000142188.12901.23190430.176501.066908.540507.40560HepG2RBM25
TMEM50BENSG00000142188.12779.34840487.063900.678108.691607.83070HepG2NELFE
TMEM50BENSG00000142188.12632.83810453.623900.480204.384703.63230HepG2RECQL
TMEM50BENSG00000142188.12453.60920706.10890-0.638406.174005.21090HepG2RPLP0
TMEM50BENSG00000142188.12439.76480330.664500.411302.400201.82300HepG2RPS19
TMEM50BENSG00000142188.12365.39850468.98680-0.360102.557501.93360HepG2SAFB2
TMEM50BENSG00000142188.12904.61670623.380900.537103.275502.54070HepG2SF3A3
TMEM50BENSG00000142188.12440.07060709.54610-0.689206.305605.27690HepG2SF3B1
TMEM50BENSG00000142188.12661.88220455.658200.538505.420404.63940HepG2SF3B4
TMEM50BENSG00000142188.12591.41170830.91030-0.490506.834705.81160HepG2SLBP
TMEM50BENSG00000142188.121321.36090789.485700.742905.354704.25700HepG2SNRNP70
TMEM50BENSG00000142188.121143.04010795.250200.523308.616507.86690HepG2SRFBP1
TMEM50BENSG00000142188.12782.31490475.603700.717909.997109.22310HepG2SRSF1
TMEM50BENSG00000142188.12885.50300690.506900.358703.917903.33090HepG2SSB
TMEM50BENSG00000142188.12698.94820427.477800.709208.586907.68860HepG2TAF15
TMEM50BENSG00000142188.12619.74010392.808100.657706.610505.32440HepG2TIA1
TMEM50BENSG00000142188.12607.10960348.992300.798707.816606.54290HepG2UCHL5
TMEM50BENSG00000142188.12767.96210541.043900.505203.133502.06290HepG2UPF2
TMEM50BENSG00000142188.12651.32240533.750400.287101.992401.46650HepG2UTP3
TMEM50BENSG00000142188.12524.66190389.833200.428403.651302.89690HepG2ZC3H8
TMEM50BENSG00000142188.12731.07250608.023000.265802.247201.73960HepG2ZNF622
TMEM50BENSG00000142188.122599.433801788.938000.539006.208805.41080K562AGGF1
TMEM50BENSG00000142188.122955.714501965.986800.588204.034702.79940K562AKAP8
TMEM50BENSG00000142188.123242.106601861.523800.8003015.6530013.88120K562AKAP8L
TMEM50BENSG00000142188.122097.115101627.871100.365303.200502.57800K562AQR
TMEM50BENSG00000142188.123457.937801953.286200.8239011.691209.62850K562ATP5C1
TMEM50BENSG00000142188.121166.44450930.530700.325902.084101.33270K562BOP1
TMEM50BENSG00000142188.122960.660702286.564600.372604.671803.39250K562CELF1
TMEM50BENSG00000142188.121628.779001225.845500.409905.590503.49190K562DDX6
TMEM50BENSG00000142188.122871.538702002.802300.519705.806904.47750K562DKC1
TMEM50BENSG00000142188.12511.65080735.67190-0.523904.013402.89780K562EFTUD2
TMEM50BENSG00000142188.121577.205901328.099600.247902.629301.45810K562EIF2S1
TMEM50BENSG00000142188.12749.709701012.00950-0.432804.853803.93740K562EIF2S2
TMEM50BENSG00000142188.12726.55670901.77850-0.311702.431701.68330K562EIF3G
TMEM50BENSG00000142188.121006.314701263.19400-0.328002.482001.70510K562EIF4A3
TMEM50BENSG00000142188.122397.253801859.553600.366305.110403.85300K562EIF4G2
TMEM50BENSG00000142188.121092.81040853.275600.356902.310501.47900K562FTO
TMEM50BENSG00000142188.12885.056201313.67130-0.569808.901107.88900K562FXR1
TMEM50BENSG00000142188.122092.673101334.763900.648702.113901.50760K562G3BP2
TMEM50BENSG00000142188.121262.51910888.310000.507106.782405.04020K562GLRX3
TMEM50BENSG00000142188.122530.762001578.107300.681303.300901.93440K562HNRNPA2B1
TMEM50BENSG00000142188.12987.672401183.42500-0.260902.145601.36050K562HNRNPU
TMEM50BENSG00000142188.121734.773501311.813000.403103.848502.39540K562IGF2BP3
TMEM50BENSG00000142188.122219.074701319.818200.749504.787202.88620K562ILF2
TMEM50BENSG00000142188.12698.78130471.704300.566904.504302.59230K562ILF3
TMEM50BENSG00000142188.123146.066701975.357200.671309.809307.99650K562KIF1C
TMEM50BENSG00000142188.12931.056601355.70880-0.542106.483005.16810K562MAGOH
TMEM50BENSG00000142188.122919.282401891.052800.626308.811606.49370K562MAK16
TMEM50BENSG00000142188.12960.567101353.02920-0.494205.646104.26680K562MATR3
TMEM50BENSG00000142188.122693.410401982.082200.442304.586203.12790K562MSI2
TMEM50BENSG00000142188.122206.180901551.116300.508103.985602.87070K562NAA15
TMEM50BENSG00000142188.121686.455701261.353700.418904.735903.12310K562NCBP2
TMEM50BENSG00000142188.121235.210801037.761800.251202.779902.03220K562NSUN2
TMEM50BENSG00000142188.12893.143201206.33000-0.433703.956002.78040K562PCBP2
TMEM50BENSG00000142188.121337.091501047.458700.352102.273101.51960K562PCBP3
TMEM50BENSG00000142188.121009.80420753.861700.421603.448401.83290K562PHF6
TMEM50BENSG00000142188.12622.509501317.12120-1.0812023.1486021.30200K562PTBP1
TMEM50BENSG00000142188.122470.804002028.899700.284202.394501.63740K562PUF60
TMEM50BENSG00000142188.122683.770202158.150400.314402.259801.30580K562PUM1
TMEM50BENSG00000142188.122678.498101845.743900.537105.588404.84860K562PUS1
TMEM50BENSG00000142188.123197.773201798.711700.8300017.7423016.21880K562RBM15
TMEM50BENSG00000142188.12906.358301263.21600-0.478904.625403.50670K562RBM22
TMEM50BENSG00000142188.121002.616001329.27340-0.406903.266602.06800K562NELFE
TMEM50BENSG00000142188.12960.907801251.41150-0.381102.557201.59820K562RPS3
TMEM50BENSG00000142188.12835.488301291.16570-0.628008.350307.12810K562SRSF1
TMEM50BENSG00000142188.121526.433001219.279500.324002.493601.50390K562SRSF5
TMEM50BENSG00000142188.121283.799101053.323300.285402.838701.65300K562SRSF7
TMEM50BENSG00000142188.121656.317301173.531400.497004.448802.79620K562STAU1
TMEM50BENSG00000142188.122843.343901734.545600.712903.286301.69180K562SUPT6H
TMEM50BENSG00000142188.12969.504101306.85640-0.430803.611902.80000K562TARDBP
TMEM50BENSG00000142188.121467.815201100.354100.415604.071603.21600K562UPF1
TMEM50BENSG00000142188.121421.78720941.549200.594503.868702.82750K562WDR3
TMEM50BENSG00000142188.121367.24140979.026400.481708.367906.97420K562WDR43
TMEM50BENSG00000142188.122670.454701929.186300.469006.233004.28910K562WRN
TMEM50BENSG00000142188.122548.013601833.625000.474605.790204.46800K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for TMEM50B is not available on ENCORE database.





19 RBPs can affect the splicing of TMEM50B :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SETMEM50BENSG00000142188.12chr21-3482831034828404348280333482809134832719348328120.101000.000220.00616includedK562SRSF1
SETMEM50BENSG00000142188.12chr21-3482831034828404348280333482809134832719348328280.071000.000000.00000includedK562FTO
SETMEM50BENSG00000142188.12chr21-348091893480939134804791348051093481152034811604-0.262000.001090.08189excludedK562XRCC6
SETMEM50BENSG00000142188.12chr21-3482831034828404348280333482809134832719348328120.058000.000000.00003includedK562FMR1
SETMEM50BENSG00000142188.12chr21-3480918934809299348047913480510934811520348116040.135000.002870.02953includedK562AQR
SETMEM50BENSG00000142188.12chr21-3482831034828404348280333482809134832719348328650.096000.000010.00022includedK562AQR
SETMEM50BENSG00000142188.12chr21-3482831034828404348280333482809134832719348328120.163000.000000.00003includedK562SUPV3L1
SETMEM50BENSG00000142188.12chr21-348376483483771634828033348280913483931634839419-0.097000.001050.01770excludedK562PUS1
SETMEM50BENSG00000142188.12chr21-3481932434819447348115203481160434821088348214960.328000.000050.00656includedK562HNRNPL
SETMEM50BENSG00000142188.12chr21-3480918934809299348047913480510934811520348116040.195000.000020.00962includedK562EIF4G2
SETMEM50BENSG00000142188.12chr21-3481932434819447348115203481160434821088348212100.170000.003260.08140includedK562UTP18
SETMEM50BENSG00000142188.12chr21-3481932434819447348115203481160434821088348214960.147000.003790.07413includedK562RBM15
SETMEM50BENSG00000142188.12chr21-3481932434819447348115203481160434821088348212100.160000.002100.04923includedK562AGGF1
SETMEM50BENSG00000142188.12chr21-3482831034828404348280333482809134832719348328120.075000.000000.00000includedK562CPSF6
SETMEM50BENSG00000142188.12chr21-3482831034828404348280333482809134832719348328120.052000.000000.00009includedK562SF3B1
SETMEM50BENSG00000142188.12chr21-3482831034828404348280333482809134832719348328120.066000.000440.06488includedK562ZC3H8
SETMEM50BENSG00000142188.12chr21-3481932434819447348115203481160434821088348214960.365000.001150.04313includedHepG2HNRNPC
SETMEM50BENSG00000142188.12chr21-3482831034828404348280333482809134832719348328120.168000.000010.00137includedHepG2SRSF9
SETMEM50BENSG00000142188.12chr21-3482831034828404348280333482809134832719348328120.108000.000000.00000includedK562HNRNPC
SETMEM50BENSG00000142188.12chr21-3481932434819447348115203481160434821088348212100.305000.000160.00395includedK562HNRNPC
A3SSTMEM50BENSG00000142188.12chr21-3483271934832828348327193483281234837648348377160.063000.000890.00627longerK562AQR
MXETMEM50BENSG00000142188.12chr21-34821088348231703482803334828091348115203481160434832719348328120.081000.000000.000941includedK562HNRNPM
MXETMEM50BENSG00000142188.12chr21-34828033348280913482831034828404348228533482317034832719348328120.092000.000270.009481includedK562SUPV3L1
MXETMEM50BENSG00000142188.12chr21-34832719348328123483764834837716348280333482809134839316348394290.095000.000000.000271includedK562HNRNPUL1

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for TMEM50B is not avaliable on ENCORE database.