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DGCR8



DGCR8

General Information

Gene Name       : DGCR8
Gene ID             : ENSG00000128191.15
Essential Gene : Yes

Functions

Localization(RBPImage: DGCR8)

Domains (AlphaFold: DGCR8)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878DGCR8ENSG00000128191.158.8812.1910.54ENCSR000AEF
HepG2DGCR8ENSG00000128191.1521.9315.3518.64ENCSR985KAT
K562DGCR8ENSG00000128191.1554.1547.3850.77ENCSR000AEO

Assays

8 Released experiments are available on ENCORE database.

Assay TypeExp_NameENCODE IDTarget labelBiosampleStatusLinked AntibodyControlsMethodNote
eCLIPeCLIP: 341ENCSR947JVRDGCR8K562ReleasedENCAB462ILEENCSR616BTD  
eCLIPeCLIP: 383ENCSR061SZVDGCR8HepG2ReleasedENCAB462ILEENCSR298SAD  
knockdown followed by RNA-seq BGKcLV02-19-D22,BGKcLV02-20-D22DGCR8K562Released   CRISPRKD% = 45.0,45.0
knockdown followed by RNA-seq BGKcLV02-20-D22,BGKcLV02-19-D30DGCR8K562Released   CRISPRKD% = 45.0,61.0
knockdown followed by RNA-seq BGKcLV02-19-D30,BGKcLV02-20-D30DGCR8K562Released   CRISPRKD% = 61.0,59.0
knockdown followed by RNA-seq BGKcLV02-20-D30,BGKcLV02-19-D41DGCR8K562Released   CRISPRKD% = 59.0,56.0
knockdown followed by RNA-seq BGKcLV02-19-D41,BGKcLV02-20-D41DGCR8K562Released   CRISPRKD% = 56.0,48.0
knockdown followed by RNA-seq BGKcLV02-20-D41,BGHcLV03-15DGCR8K562Released   CRISPRKD% = 48.0,no band






  eCLIP  
  RBP    Exp_UID    Cell_Line    ENCODE_ACCESSION    Control_ENCODE_ACCESSION    ENCODE_Antibody_ID    Antibody    Lot_num    Status    Project  
DGCR8341K562ENCSR947JVRENCSR616BTDENCAB462ILEA302-468A1ReleasedENCODE3
DGCR8383HepG2ENCSR061SZVENCSR298SADENCAB462ILEA302-468A1ReleasedENCODE3


  Antibody Validation  
  GeneName    Antibody_DCC_ID    Product_ID    Lot_ID    Phosphate    HepG2 Primary Validation    K562 Primary Validation    HepG2 Secondary Validation    K562 Secondary Validation  
DGCR8ENCAB462ILEA302-468A1Released, ENCODE3Released, ENCODE3BGKcLV02-19-D30, Released, ENCODE3


  KD RNA-Seq  
  GeneName    Cell_Line    Method    Exp_ID    Control_ID    Sample_reps    Control_reps    KD%    Status    Project    Note  
DGCR8K562shRNABGKLV28-13,BGKLV28-14BGKLV28-1,BGKLV28-20.0,0.0NotSatisfiedENCODE3
DGCR8K562shRNABGKLV32-25,BGKLV32-26BGKLV32-1,BGKLV32-2NotSatisfiedENCODE3
DGCR8K562shRNABGKLV32-27,BGKLV32-28BGKLV32-1,BGKLV32-2NotSatisfiedENCODE3
DGCR8HepG2shRNABGHLV18-5,BGHLV18-6BGHLV18-1,BGHLV18-2NotSatisfiedENCODE3
DGCR8HepG2shRNABGHLV20-17,BGHLV20-18BGHLV20-1,BGHLV20-2redo transfection,redo transfectionNotSatisfiedENCODE3
DGCR8HepG2shRNABGHLV30-29,BGHLV30-30BGHLV30-1,BGHLV30-2NotSatisfiedENCODE3
DGCR8HepG2shRNABGHLV31-29,BGHLV31-30BGHLV31-1,BGHLV31-2NotSatisfiedENCODE3
DGCR8HepG2shRNABGHLV31-31,BGHLV31-32BGHLV31-1,BGHLV31-2NotSatisfiedENCODE3
DGCR8K562CRISPRBGKcLV02-19,BGKcLV02-20BGKcLV02-1,BGKcLV02-23.3,0.0NotSatisfiedENCODE3
DGCR8K562CRISPRBGKcLV02-19-D12,BGKcLV02-20-D12BGKcLV02-1,BGKcLV02-20.0,0.0NotSatisfiedENCODE3
DGCR8K562CRISPRBGKcLV02-20-D12,BGKcLV02-19-D22BGKcLV02-1,BGKcLV02-20.0,45.0NotSatisfiedENCODE3
DGCR8K562CRISPRBGKcLV02-19-D22,BGKcLV02-20-D22BGKcLV02-1,BGKcLV02-245.0,45.0ReleasedENCODE3
DGCR8K562CRISPRBGKcLV02-20-D22,BGKcLV02-19-D30BGKcLV02-1,BGKcLV02-245.0,61.0ReleasedENCODE3
DGCR8K562CRISPRBGKcLV02-19-D30,BGKcLV02-20-D30BGKcLV02-1,BGKcLV02-261.0,59.0ReleasedENCODE3
DGCR8K562CRISPRBGKcLV02-20-D30,BGKcLV02-19-D41BGKcLV02-1,BGKcLV02-259.0,56.0ReleasedENCODE3
DGCR8K562CRISPRBGKcLV02-19-D41,BGKcLV02-20-D41BGKcLV02-1,BGKcLV02-256.0,48.0ReleasedENCODE3
DGCR8K562CRISPRBGKcLV02-20-D41,BGHcLV03-15BGKcLV02-1,BGKcLV02-248.0,no bandReleasedENCODE3
DGCR8HepG2CRISPRBGHcLV03-15,BGHcLV03-16BGHcLV03-1,BGHcLV03-2no band,NotSatisfiedENCODE3
DGCR8HepG2CRISPRBGHcLV03-15-D12,BGHcLV03-16-D12BGHcLV03-1,BGHcLV03-2no band,NotSatisfiedENCODE3
DGCR8HepG2CRISPRBGHcLV03-16-D12,BGHcLV03-15-D21BGHcLV03-1,BGHcLV03-2,no bandNotSatisfiedENCODE3
DGCR8HepG2CRISPRBGHcLV03-15-D21,BGHcLV03-16-D21BGHcLV03-1,BGHcLV03-2no band,NotSatisfiedENCODE3
DGCR8HepG2CRISPRBGHcLV03-16-D21,BGHcLV03-15-D29BGHcLV03-1,BGHcLV03-2NotSatisfiedENCODE3
DGCR8HepG2CRISPRBGHcLV03-15-D29,BGHcLV03-16-D29BGHcLV03-1,BGHcLV03-2NotSatisfiedENCODE3
DGCR8HepG2CRISPRBGHcLV03-16-D29,BGHcLV03-15-D40BGHcLV03-1,BGHcLV03-2,no bandNotSatisfiedENCODE3
DGCR8HepG2CRISPRBGHcLV03-15-D40,BGHcLV03-16-D40BGHcLV03-1,BGHcLV03-2no band,NotSatisfiedENCODE3
DGCR8HepG2CRISPRBGHcLV03-16-D40,BGHcLV03-1,BGHcLV03-2NotSatisfiedENCODE3


  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  
    DGCR8: Click to RBP Image Database
  • Nuclei
  • Nucleoplasm
  • Mutually Exclusive from Nucleolus
  • Speckles
  • Nuclear release mitosis












    • RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela
    DGCR8Product_ID: A302-468A
    Lot_ID: 1
    Source: Bethyl Labs
    Target Name: DGCR8-human    		 HepG2_Bethyl_A302-468A_1_DGCR8.png<br>Caption: IP-Western Blot analysis of HepG2 whole cell lysate using DGCR8 specific antibody. Lane 1 is 1% of twenty million whole cell lysate input and lane 2 is 25% of IP enrichment using rabbit normal IgG (lanes under 'IgG'). Lane 3 is 1% of twenty million whole cell lysate input and lane 4 is 10% IP enrichment using rabbit polyclonal anti-DGCR8 antibody (lanes under 'DGCR8').
    		 K562_Bethyl_A302-468A_1_DGCR8.png<br>Caption: IP-Western Blot analysis of K562 whole cell lysate using DGCR8 specific antibody. Lane 1 is 1% of twenty million whole cell lysate input and lane 2 is 25% of IP enrichment using rabbit normal IgG (lanes under 'IgG'). Lane 3 is 1% of twenty million whole cell lysate input and lane 4 is 10% IP enrichment using rabbit polyclonal anti-DGCR8 antibody (lanes under 'DGCR8').
    		 DGCR8-K562-D22-CRISPR.png<br>Caption: Western blot following CRISPR against DGCR8 in K562 whole cell lysate using DGCR8 specific antibody. Lane 1 is a ladder, lane 2 is K562 non-targeting control knockdown, lane 3 and 4 are two different CRISPR against DGCR8. DGCR8 protein appears as the green arrow, GAPDH serves as a control and appears in red arrow. This western blot was done 22 days after the CRISPR experiment process.
    DGCR8-K562-D41-CRISPR.png<br>Caption: Western blot following CRISPR against DGCR8 in K562 whole cell lysate using DGCR8 specific antibody. Lane 1 is a ladder, lane 2 is K562 non-targeting control knockdown, lane 3 and 4 are two different CRISPR against DGCR8. DGCR8 protein appears as the green arrow, GAPDH serves as a control and appears in red arrow. This western blot was done 41 days after the CRISPR experiment process.
    DGCR8-K562-D30-CRISPR.png<br>Caption: Western blot following CRISPR against DGCR8 in K562 whole cell lysate using DGCR8 specific antibody. Lane 1 is a ladder, lane 2 is K562 non-targeting control knockdown, lane 3 and 4 are two different CRISPR against DGCR8. DGCR8 protein appears as the green arrow, GAPDH serves as a control and appears in red arrow. This western blot was done 30 days after the CRISPR experiment process.
    		 AdrenalGland_Bethyl_A302-468A_1_DGCR8.png<br>Caption: IP-Western Blot analysis of human adrenal gland lysate using DGCR8 specific antibody. Lane 1 is 1% of 10 million tissue lysate input and lane 2 is 10% of IP enrichment using rabbit polyclonal anti-DGCR8 antibody (lanes under 'DGCR8')). Lanes 3 and 4 indicate a technical replicate of lanes 1 and 2.








    RNA Targets
    • DGCR8 protein binds to 2,677 RNA regions.  





    Proteins bound to RNA
    • DGCR8 RNA is bound by 57 proteins.  






    DGCR8 protein has 2,677 RNA targets:

    Only display 100 entries as example. Please click "View All" button to see all 2,677 entries.     

    RBP Chr Start End Strand log2(fold change) -log(p-value) Cell Line Matched Gene Matched Area
    DGCR8chr125821857758218661-7.1875236.96325K562CTDSP2intron-Distal
    DGCR8chr1774772427477308+3.121154.27243HepG2SNORA67, EIF4A1, SENP3-EIF4A15'-UTR,intron-Distal
    DGCR8chr9134141703134141750-4.048103.10925K562FAM78Aintron-Distal
    DGCR8chrX5358328153583351-5.8239619.85066HepG2HUWE1intron-Distal
    DGCR8chr1168007898168007990+4.818046.04484K562DCAF6intron-Distal
    DGCR8chr29753257297532623-4.169333.48031HepG2SEMA4Cintron-Distal
    DGCR8chr177941816579418203+6.2151413.20275K562RP11-1055B8.7intron-Distal
    DGCR8chr12123869399123869495+3.202375.53028K562SETD8intron-Distal
    DGCR8chr102178552821785555-5.5322510.33133HepG2CASC10intron-Distal
    DGCR8chr194275780142757854-3.466843.34333HepG2AC006486.9, ERFintron-Distal
    DGCR8chr7130562226130562258-8.4743276.64870HepG2MIR29B1intron-Distal
    DGCR8chr224229866342298697+7.6140946.34593HepG2SREBF2intron-Distal
    DGCR8chr206255172462551796+3.035293.22699HepG2DNAJC5intron-Distal
    DGCR8chr8142440368142440454+5.788837.29208K562PTP4A3intron-Distal
    DGCR8chr34905842749058467-6.5992827.99554HepG2DALRD35'-UTR,intron-Distal
    DGCR8chr125442778554427808+8.0017538.13625K562HOXC5, HOXC4, RP11-834C11.14, RP11-834C11.12intron-Distal
    DGCR8chr214573459145734718+3.493083.45522HepG2PFKLintron-Distal
    DGCR8chr99784734597847365+5.7465927.91871HepG2C9orf3intron-Distal
    DGCR8chr1621458162145847-5.477477.65756K562RP11-304L19.3, PKD1intron-Distal
    DGCR8chr1121555142155541-5.7438544.76963HepG2INS-IGF2, IGF2intron-Distal
    DGCR8chr99784813997848177+8.56690118.56705HepG2C9orf3intron-Distal,intron-Proximal
    DGCR8chr1121558922155942-5.7553849.72934HepG2IGF2, INS-IGF2intron-Distal
    DGCR8chr99692924296929284+4.536816.12871HepG2RP11-2B6.3intron-Distal
    DGCR8chr29753546497535521-3.237366.30230K562SEMA4Cintron-Distal
    DGCR8chr1182360844182360867-3.4688814.88035K562GLUL5'-UTR,intron-Distal
    DGCR8chr9139564252139564270+5.5517337.37278K562EGFL7intron-Proximal
    DGCR8chr11948750619487567-4.439625.64979HepG2UBR4CDS,intron-Distal
    DGCR8chr9116970341116970394+3.106267.33530HepG2COL27A1intron-Distal
    DGCR8chr35230248152302544-4.597119.64625HepG2WDR82intron-Distal
    DGCR8chr178021111480211180-3.940594.29056K562CSNK1D3'-UTR,CDS,intron-Distal,intron-Proximal
    DGCR8chr11665373016653799-4.116853.52314K562FBXO42intron-Distal
    DGCR8chr126299710962997181+7.5425332.27545K562RP11-631N16.2intron-Distal
    DGCR8chr112426381242687-3.422074.23783HepG2ACAP3intron-Distal,intron-Proximal
    DGCR8chr222007358320073610+5.9104226.37812HepG2DGCR8CDS
    DGCR8chr6167369127167369238-3.569083.45522HepG2RNASET2, RP11-514O12.4intron-Distal,intron-Proximal
    DGCR8chrX7350701473507102-5.4439422.24735HepG2FTXintron-Distal
    DGCR8chr222203713222037179+4.564564.40356K562PPIL2intron-Distal
    DGCR8chr8141742744141742829-6.3460118.27075HepG2PTK2intron-Distal
    DGCR8chr2232573851232573898+3.544343.54163HepG2PTMAintron-Distal
    DGCR8chr11567829567868-6.6232821.20673HepG2MIR210HGintron-Distal
    DGCR8chr1716161061616166-5.4554810.06584HepG2MIR22HGintron-Distal,intron-Proximal
    DGCR8chr125821816958218204-6.2558419.12711HepG2CTDSP2intron-Distal,intron-Proximal
    DGCR8chr5134686683134686729-4.902585.67221K562H2AFYintron-Distal,intron-Proximal
    DGCR8chr222007356020073583+6.8662726.38346HepG2DGCR8CDS
    DGCR8chr99784750297847507+6.5580826.85718HepG2C9orf3intron-Distal
    DGCR8chr99693826996938277+7.7719578.02912HepG2RP11-2B6.3intron-Distal
    DGCR8chr77617888276179030+4.390603.34538K562AC004980.7, UPK3Bintron-Distal,intron-Proximal
    DGCR8chr206255172062551810+3.252145.38659K562DNAJC5intron-Distal
    DGCR8chr191811200618112075+5.477477.65756K562ARRDC25'-UTR
    DGCR8chr1623191262319154+3.214553.72472HepG2MIR940intron-Distal
    DGCR8chr156557868165578721-4.358843.10925K562PARP16CDS,intron-Distal,intron-Proximal
    DGCR8chr194652221846522272+8.1038360.08386K562CCDC61intron-Distal
    DGCR8chr5167986420167986560-4.0435811.18955K562PANK3intron-Distal
    DGCR8chr171771746817717516-3.595014.47834HepG2SREBF1intron-Distal,intron-Proximal
    DGCR8chr116785830167858361-5.7162417.83540K562CHKAintron-Distal
    DGCR8chr63293715032937207+3.465914.35288K562BRD2intron-Distal,intron-Proximal
    DGCR8chr429358802936025-4.117043.05559HepG2MFSD105'-UTR,intron-Distal
    DGCR8chr203359268033592722-4.466845.24066HepG2TRPC4APintron-Distal
    DGCR8chr224559686045596863-6.6349116.72845K562KIAA0930intron-Distal
    DGCR8chr1205417502205417614-7.8137354.98208K562LEMD1intron-Distal
    DGCR8chr112797271279801-4.117043.05559HepG2DVL1intron-Distal
    DGCR8chr168965486389654949+3.282843.18683K562CPNE7intron-Distal
    DGCR8chr135062317350623215-6.3731333.58852K562DLEU2intron-Distal
    DGCR8chr126963409369634148+3.203813.55543HepG2CPSF6intron-Distal
    DGCR8chr206233554662335623-5.100587.33095HepG2ARFRP1intron-Distal
    DGCR8chr194652338146523421+4.241613.10925K562CCDC61intron-Distal
    DGCR8chr125821853958218568-6.2410018.84256HepG2CTDSP2intron-Distal
    DGCR8chr2038981573898187+11.86310400.00000HepG2PANK2intron-Distal
    DGCR8chr178021134680211425-4.9700412.62537K562CSNK1Dintron-Distal
    DGCR8chr135062118750621292-4.6691813.57962HepG2DLEU2intron-Distal
    DGCR8chr171924995819250005-4.874807.08501HepG2B9D1intron-Distal
    DGCR8chr74483702144837055+3.254864.00954HepG2PPIAintron-Distal
    DGCR8chr84151779241517826-7.5706344.00646K562ANK1intron-Distal
    DGCR8chr222005199120052039+5.488109.86363K562TANGO2intron-Proximal
    DGCR8chr5149112415149112450+8.6223586.81804K562PPARGC1Bintron-Distal
    DGCR8chr102178511821785186-4.419628.03149HepG2CASC10intron-Distal
    DGCR8chr224650864046508695+4.865253.88813HepG2FLJ273653'-UTR
    DGCR8chr1121556852155762-4.8405258.74807HepG2INS-IGF2, IGF2intron-Distal
    DGCR8chr222007369620073718+3.5032010.79574HepG2DGCR8CDS
    DGCR8chr224229869742298709+6.3631037.87023HepG2SREBF2intron-Distal
    DGCR8chr145442119154421252-3.439624.89825HepG2BMP45'-UTR,intron-Distal
    DGCR8chr202545939325459446-3.703813.11730HepG2NINLintron-Distal
    DGCR8chr165257997252580049-3.311794.09586HepG2TOX3intron-Distal
    DGCR8chr79969165199691684-10.56461283.57830K562MCM7intron-Distal
    DGCR8chr9101558733101558749-6.2217130.08159K562ANKS6CDS,intron-Distal
    DGCR8chr33801094338010965+8.1878158.51374K562CTDSPLintron-Distal
    DGCR8chr9101558379101558423-5.0508711.81473K562ANKS6CDS,intron-Distal
    DGCR8chr221995162919951673+5.300656.04484K562COMTCDS,intron-Proximal
    DGCR8chrX109298707109298800+5.4594030.74273K562TMEM164intron-Distal
    DGCR8chr117504643775046454-4.203818.30119HepG2ARRB1intron-Distal
    DGCR8chr178021156380211602-3.837333.05559HepG2CSNK1Dintron-Distal
    DGCR8chr106513276165132778-7.0867524.48208K562JMJD1Cintron-Distal
    DGCR8chr172844388628443948+6.2280137.85581HepG2NSRP1intron-Proximal
    DGCR8chr168926710589267172-3.623118.31985HepG2SLC22A31intron-Distal
    DGCR8chr99784789097847949+7.22134166.68647HepG2C9orf3intron-Distal
    DGCR8chr1620543122054391-3.282843.18683K562ZNF598intron-Distal
    DGCR8chr14105934703105934746+3.261553.55543HepG2MTA1intron-Distal,intron-Proximal
    DGCR8chr177996267479962720+3.570097.46990HepG2ASPSCR1intron-Distal
    DGCR8chr17153333371533341-9.87903400.00000K562ZRANB2intron-Distal
    DGCR8chr79969145899691499-7.66996167.18965K562MCM7intron-Distal




    57 proteins are bound to DGCR8 RNA:

    Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
    chr222009931920099344+3'-UTR4.503245.46178K562ZC3H11A
    chr222007321520073265+3'-UTR,5'-UTR3.2187841.44017K562ZNF622
    chr222009843020098474+3'-UTR3.002733.09370K562NOLC1
    chr222009754520097642+3'-UTR,CDS,intron-Proximal3.250326.23779HepG2PPIG
    chr222007317120073261+3'-UTR,5'-UTR,intron-Proximal3.5360214.57530HepG2SF3A3
    chr222007320720073253+3'-UTR,5'-UTR,intron-Proximal6.30584400.00000K562DGCR8
    chr222007319820073268+3'-UTR,5'-UTR,intron-Proximal3.869337.33440K562U2AF1
    chr222007325320073260+3'-UTR,5'-UTR6.54043400.00000K562DGCR8
    chr222007347120073478+3'-UTR,5'-UTR6.85839115.61421K562DGCR8
    chr222009843020098483+3'-UTR3.854663.81071K562HNRNPC
    chr222007329220073305+3'-UTR,5'-UTR7.7455554.58978K562DGCR8
    chr222009754720097660+3'-UTR,CDS,intron-Proximal3.222829.88509K562PUM1
    chr222007327920073313+3'-UTR,5'-UTR5.5060210.65697K562UCHL5
    chr222009875020098782+3'-UTR3.104035.54628K562ZC3H11A
    chr222007340920073459+3'-UTR,5'-UTR7.21280150.18935K562DGCR8
    chr222007345920073471+3'-UTR,5'-UTR7.49236136.47139K562DGCR8
    chr222007321120073279+3'-UTR,5'-UTR3.7278143.61495K562SF3B4
    chr222007343020073474+3'-UTR,5'-UTR3.286643.91534K562HNRNPA1
    chr222009763420097713+3'-UTR3.797733.25119K562SRSF7
    chr222007325220073275+3'-UTR,5'-UTR5.8283911.75303HepG2U2AF2
    chr222007347420073540+3'-UTR,5'-UTR,CDS3.8033135.57391K562RBFOX2
    chr222007342020073474+3'-UTR,5'-UTR3.5560522.96361K562RBFOX2
    chr222007347820073540+3'-UTR,5'-UTR,CDS7.12381400.00000K562DGCR8
    chr222009906620099120+3'-UTR5.0873016.70466K562ZC3H11A
    chr222007325120073285+3'-UTR,5'-UTR5.120284.71718K562SMNDC1
    chr222009903220099066+3'-UTR3.937315.44797K562ZC3H11A
    chr222007335520073388+3'-UTR,5'-UTR6.3857168.24132K562DROSHA
    chr222009923320099266+3'-UTR3.619025.24375K562ZC3H11A
    chr222007347820073520+3'-UTR,5'-UTR,CDS6.05536400.00000K562DROSHA
    chr222007326920073286+3'-UTR,5'-UTR4.6490116.91180HepG2DGCR8
    chr222007319920073252+3'-UTR,5'-UTR,intron-Proximal4.7826235.93386HepG2DGCR8
    chr222009755320097670+3'-UTR,CDS3.1051112.03943K562ZNF800
    chr222007324720073284+3'-UTR,5'-UTR7.42849400.00000K562DROSHA
    chr222007344020073552+3'-UTR,5'-UTR,CDS6.0493042.27976HepG2DROSHA
    chr222007330520073347+3'-UTR,5'-UTR9.17401125.38998K562DGCR8
    chr222007326020073266+3'-UTR,5'-UTR6.6315186.15820K562DGCR8
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    chr222009656020096615+intron-Proximal3.265658.22619K562EFTUD2
    chr222007487120074922+intron-Proximal5.174616.92547HepG2RBM22
    chr222007484820074903+intron-Proximal5.411555.35117HepG2PRPF8
    chr222007420820074243+intron-Proximal3.709148.49839K562RBFOX2
    chr222009495520094963+intron-Proximal6.8990023.54371K562AQR
    chr222009748520097509+intron-Proximal4.052623.52230K562AQR
    chr222009380020093847+intron-Proximal5.1464313.75908K562AQR
    chr222007915520079196+intron-Proximal3.658404.63311K562AQR
    chr222009655920096619+intron-Proximal5.5451233.86141K562AQR
    chr222009422120094276+intron-Proximal3.492117.18794K562AQR
    chr222009472420094754+intron-Proximal4.436245.25423K562SMNDC1
    chr222007461820074682+intron-Proximal5.110007.97588HepG2SF3B4
    chr222007464920074670+intron-Proximal4.230164.69223K562SF3B4
    chr222009424520094255+intron-Proximal3.516956.12893K562BUD13
    chr222009656920096617+intron-Proximal4.648973.90539HepG2RBM22
    chr222009653020096559+intron-Proximal6.1156048.52408K562AQR
    ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




    The DGCR8 protein binds to its own RNA.

    RBP Chr Start End Strand log2(fold change) -log(p-value) Cell Line Matched Gene Matched Area
    DGCR8chr222007320720073253+6.30584400.00000K562DGCR83'-UTR,5'-UTR,intron-Proximal
    DGCR8chr222007325320073260+6.54043400.00000K562DGCR83'-UTR,5'-UTR
    DGCR8chr222007347120073478+6.85839115.61421K562DGCR83'-UTR,5'-UTR
    DGCR8chr222007329220073305+7.7455554.58978K562DGCR83'-UTR,5'-UTR
    DGCR8chr222007340920073459+7.21280150.18935K562DGCR83'-UTR,5'-UTR
    DGCR8chr222007345920073471+7.49236136.47139K562DGCR83'-UTR,5'-UTR
    DGCR8chr222007347820073540+7.12381400.00000K562DGCR83'-UTR,5'-UTR,CDS
    DGCR8chr222007326920073286+4.6490116.91180HepG2DGCR83'-UTR,5'-UTR
    DGCR8chr222007319920073252+4.7826235.93386HepG2DGCR83'-UTR,5'-UTR,intron-Proximal
    DGCR8chr222007330520073347+9.17401125.38998K562DGCR83'-UTR,5'-UTR
    DGCR8chr222007326020073266+6.6315186.15820K562DGCR83'-UTR,5'-UTR
    DGCR8chr222007335720073383+6.6023623.32975K562DGCR83'-UTR,5'-UTR
    DGCR8chr222007341820073475+7.1049034.60566HepG2DGCR83'-UTR,5'-UTR
    DGCR8chr222007325220073269+4.3432918.36605HepG2DGCR83'-UTR,5'-UTR
    DGCR8chr222007347520073539+6.9483566.97346HepG2DGCR83'-UTR,5'-UTR,CDS
    DGCR8chr222007326620073269+6.2419861.15018K562DGCR83'-UTR,5'-UTR
    DGCR8chr222007329320073343+5.7612025.31133HepG2DGCR83'-UTR,5'-UTR
    DGCR8chr222007326920073285+7.3500376.25104K562DGCR83'-UTR,5'-UTR
    DGCR8chr222006783820067861+6.1657620.49690K562DGCR85'-UTR
    DGCR8chr222006786220067906+3.6580510.04256HepG2DGCR85'-UTR
    DGCR8chr222006789820067907+6.3245747.45982K562DGCR85'-UTR,intron-Proximal
    DGCR8chr222007358320073610+5.9104226.37812HepG2DGCR8CDS
    DGCR8chr222007356020073583+6.8662726.38346HepG2DGCR8CDS
    DGCR8chr222007369620073718+3.5032010.79574HepG2DGCR8CDS
    DGCR8chr222007371820073750+4.5266322.37710HepG2DGCR8CDS
    DGCR8chr222007415420074187+6.5524862.71255K562DGCR8CDS
    DGCR8chr222007354020073561+5.8342170.20636K562DGCR8CDS
    DGCR8chr222007393520073967+5.6148036.78169K562DGCR8CDS
    DGCR8chr222007387720073935+5.7159682.66811K562DGCR8CDS
    DGCR8chr222007363220073658+8.94970400.00000K562DGCR8CDS
    DGCR8chr222007375420073803+5.2184074.45836K562DGCR8CDS
    DGCR8chr222007361620073623+7.68790149.19296K562DGCR8CDS
    DGCR8chr222007362320073632+9.30692256.01837K562DGCR8CDS
    DGCR8chr222007371920073749+4.8542171.83307K562DGCR8CDS
    DGCR8chr222007409320074154+6.07694400.00000K562DGCR8CDS
    DGCR8chr222007353920073560+6.3483620.49327HepG2DGCR8CDS
    DGCR8chr222007398520074074+6.5414944.73285HepG2DGCR8CDS
    DGCR8chr222007356220073616+5.93105400.00000K562DGCR8CDS
    DGCR8chr222007418720074213+5.5139341.27357K562DGCR8CDS,intron-Proximal
    DGCR8chr222007396720074068+5.28119400.00000K562DGCR8CDS
    DGCR8chr222007388420073949+5.4467834.02043HepG2DGCR8CDS
    DGCR8chr222007364120073668+6.2641441.79483HepG2DGCR8CDS
    DGCR8chr222007369320073719+5.5916039.29846K562DGCR8CDS
    DGCR8chr222007406820074093+5.2538842.68582K562DGCR8CDS
    DGCR8chr222007361020073641+6.6341859.72699HepG2DGCR8CDS
    DGCR8chr222007375120073804+5.7183536.43096HepG2DGCR8CDS
    DGCR8chr222007410020074230+5.4442244.46330HepG2DGCR8CDS,intron-Proximal
    DGCR8chr222007383120073877+6.1385872.27239K562DGCR8CDS
    DGCR8chr222007384520073884+6.5368124.16395HepG2DGCR8CDS
    DGCR8chr222007439920074446+4.8518919.82061HepG2DGCR8intron-Distal
    DGCR8chr222007439720074457+6.2646467.46403K562DGCR8intron-Distal
    DGCR8chr222007454520074574+4.3832720.97245K562DGCR8intron-Distal
    DGCR8chr222006885820068929+4.512144.96989HepG2DGCR8intron-Distal
    DGCR8chr222007735120077400+3.2503417.45993K562DGCR8intron-Proximal
    DGCR8chr222007319920073207+5.9118553.54244K562DGCR8intron-Proximal


    Diffrential Expression

    • The Knockdown/knockout assay for DGCR8 is not available on ENCORE database.

    • 91 RBPs can affect the levels of DGCR8.  








    The Knockdown/knockout RNA-Seq assay for DGCR8 is not available on ENCORE database.





    91 RBPs can affect the gene expression of DGCR8 :

    Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
    DGCR8ENSG00000128191.91002.38710635.110300.658305.955304.62950HepG2ABCF1
    DGCR8ENSG00000128191.9832.66990644.026600.370503.931203.23020HepG2ACO1
    DGCR8ENSG00000128191.9667.53470421.454500.663405.786304.41390HepG2ADAR
    DGCR8ENSG00000128191.9911.50750647.005700.494406.279905.16890HepG2AKAP8L
    DGCR8ENSG00000128191.9560.77650385.159900.541903.448702.57200HepG2ASCC1
    DGCR8ENSG00000128191.9889.88200667.231300.415302.168401.34220HepG2BCCIP
    DGCR8ENSG00000128191.9546.99680365.935500.579803.842002.93870HepG2CIRBP
    DGCR8ENSG00000128191.9626.72790837.04820-0.417503.915303.05760HepG2DAZAP1
    DGCR8ENSG00000128191.9887.88630616.144400.527006.582805.62260HepG2DKC1
    DGCR8ENSG00000128191.9703.49220424.777500.727706.083404.76320HepG2EEF2
    DGCR8ENSG00000128191.9586.49940368.211100.671504.901904.12440HepG2EIF2S1
    DGCR8ENSG00000128191.9719.07350481.823100.577505.521403.90720HepG2EIF2S2
    DGCR8ENSG00000128191.9619.66660344.809900.845607.571606.14090HepG2EIF3D
    DGCR8ENSG00000128191.9669.13150518.489600.367902.577501.53590HepG2EIF3G
    DGCR8ENSG00000128191.9942.28820406.863901.2115015.4449013.94990HepG2EIF4A3
    DGCR8ENSG00000128191.9967.64600396.239701.2880013.9165012.43860HepG2EIF4B
    DGCR8ENSG00000128191.9767.86560550.198500.480803.576902.34130HepG2ESF1
    DGCR8ENSG00000128191.91472.17670985.798900.5785010.648009.59360HepG2ETF1
    DGCR8ENSG00000128191.9934.59850629.279200.570506.107404.86430HepG2EWSR1
    DGCR8ENSG00000128191.9868.58750641.319200.437502.667101.91060HepG2FIP1L1
    DGCR8ENSG00000128191.9440.52330275.467100.677205.291004.21350HepG2FUBP3
    DGCR8ENSG00000128191.9787.52100410.668200.9392010.129508.88610HepG2FXR1
    DGCR8ENSG00000128191.91130.55800380.871001.5696027.3966025.38840HepG2G3BP1
    DGCR8ENSG00000128191.9879.65870404.453101.1209014.7077012.68320HepG2G3BP2
    DGCR8ENSG00000128191.9518.07390307.004300.754805.797204.49750HepG2GEMIN5
    DGCR8ENSG00000128191.9585.68820428.463800.450902.992402.32290HepG2HNRNPA1
    DGCR8ENSG00000128191.9676.42870812.60420-0.264602.102201.47080HepG2HNRNPF
    DGCR8ENSG00000128191.9710.24740385.862400.880109.171907.95880HepG2HNRNPK
    DGCR8ENSG00000128191.9595.62830442.511100.428603.055302.05800HepG2HNRNPM
    DGCR8ENSG00000128191.9576.01860473.426000.282901.931501.41600HepG2HNRNPU
    DGCR8ENSG00000128191.9783.28320387.117201.0167011.6905010.40650HepG2IGF2BP2
    DGCR8ENSG00000128191.9818.74860363.413001.171705.457804.10320HepG2IGF2BP3
    DGCR8ENSG00000128191.9735.22890389.429600.916707.581405.83850HepG2KHSRP
    DGCR8ENSG00000128191.91030.74290780.651600.400802.194501.46180HepG2LARP4
    DGCR8ENSG00000128191.9681.88290506.278600.429502.689601.57140HepG2LARP7
    DGCR8ENSG00000128191.91047.27770410.812201.3500020.9634019.24760HepG2MAGOH
    DGCR8ENSG00000128191.9607.31160428.588400.502703.179201.44640HepG2MARK2
    DGCR8ENSG00000128191.9967.46040413.085601.2277015.5269014.12400HepG2MATR3
    DGCR8ENSG00000128191.9584.05340360.864300.694503.299502.15160HepG2METAP2
    DGCR8ENSG00000128191.9891.71630422.794901.0765012.8647011.55660HepG2NCBP2
    DGCR8ENSG00000128191.9721.46770503.804600.518002.848901.39560HepG2NKRF
    DGCR8ENSG00000128191.9989.57140830.025000.253502.032501.37620HepG2NOL12
    DGCR8ENSG00000128191.9567.61120404.314700.489303.417201.62830HepG2NUP35
    DGCR8ENSG00000128191.9455.95510257.750300.822804.450402.44230HepG2PA2G4
    DGCR8ENSG00000128191.9564.38640376.429500.584203.890003.04560HepG2PABPC4
    DGCR8ENSG00000128191.9618.24900468.624000.399703.401802.47190HepG2PARN
    DGCR8ENSG00000128191.9692.14450405.615800.770909.377508.36830HepG2PCBP1
    DGCR8ENSG00000128191.9364.22580506.00530-0.474302.689701.89220HepG2PRPF8
    DGCR8ENSG00000128191.9688.57850412.730000.738309.948109.03690HepG2PTBP1
    DGCR8ENSG00000128191.91014.06130841.207900.269502.416401.85490HepG2PUM1
    DGCR8ENSG00000128191.91041.78520840.556600.309502.803602.12820HepG2PUM2
    DGCR8ENSG00000128191.9804.92340655.974700.295102.649902.04310HepG2PUS1
    DGCR8ENSG00000128191.91146.46900823.954800.476505.994605.30450HepG2RBM22
    DGCR8ENSG00000128191.9649.30240405.677500.678506.658305.65160HepG2RBM25
    DGCR8ENSG00000128191.9907.84860610.506800.572304.481903.20110HepG2RBM27
    DGCR8ENSG00000128191.9720.71450495.760100.539703.161602.02620HepG2RCC2
    DGCR8ENSG00000128191.91029.55890459.328201.1643026.5362025.21070HepG2NELFE
    DGCR8ENSG00000128191.9852.17790427.803000.9941018.6149017.25270HepG2RECQL
    DGCR8ENSG00000128191.91108.90770875.373600.341102.463401.81290HepG2RPLP0
    DGCR8ENSG00000128191.9563.16340335.531000.747007.135806.20160HepG2RPS19
    DGCR8ENSG00000128191.9746.73200563.019500.407302.318301.58240HepG2RPS2
    DGCR8ENSG00000128191.9518.35560421.613100.297902.014501.45080HepG2SAFB2
    DGCR8ENSG00000128191.9528.11930336.732700.649204.872103.63750HepG2SERBP1
    DGCR8ENSG00000128191.91348.23690883.400000.609804.359603.50330HepG2SF3A3
    DGCR8ENSG00000128191.9817.13110429.703800.9271015.8227014.58710HepG2SF3B4
    DGCR8ENSG00000128191.9635.90630491.682700.371003.439202.73460HepG2SMN1
    DGCR8ENSG00000128191.9874.31640448.518300.9629017.8186016.83720HepG2SRSF1
    DGCR8ENSG00000128191.91115.16070782.433000.511108.100407.10170HepG2SRSF5
    DGCR8ENSG00000128191.91188.08230808.047400.556009.700808.85480HepG2SSB
    DGCR8ENSG00000128191.9485.92060370.435800.391402.310201.54470HepG2TIA1
    DGCR8ENSG00000128191.9584.44540460.061800.345102.335701.86850HepG2TIAL1
    DGCR8ENSG00000128191.9988.24460774.220600.352003.087102.15920HepG2TUFM
    DGCR8ENSG00000128191.9786.54670548.632600.519603.987703.23940HepG2U2AF1
    DGCR8ENSG00000128191.9558.65430385.765300.534103.464902.61990HepG2UCHL5
    DGCR8ENSG00000128191.91049.28740756.382000.472106.251605.41000HepG2UTP3
    DGCR8ENSG00000128191.9923.65990642.863400.522703.672802.84610HepG2XRN2
    DGCR8ENSG00000128191.9685.69860488.533700.489005.668004.75940HepG2ZC3H8
    DGCR8ENSG00000128191.93377.910404706.16200-0.4784012.7140011.59340K562AGGF1
    DGCR8ENSG00000128191.94312.262205171.21320-0.262102.280201.40020K562AKAP8
    DGCR8ENSG00000128191.93685.147904896.93860-0.410204.883104.00470K562AKAP8L
    DGCR8ENSG00000128191.93297.226102376.628400.472208.461307.07340K562EIF3G
    DGCR8ENSG00000128191.93164.241502658.925800.250902.627801.51480K562EIF4B
    DGCR8ENSG00000128191.98836.152407345.865100.266404.254403.09680K562EIF4G2
    DGCR8ENSG00000128191.93692.201103070.659100.265803.416002.75320K562FXR1
    DGCR8ENSG00000128191.91568.495002213.53500-0.497003.553802.72920K562G3BP2
    DGCR8ENSG00000128191.93856.111004712.67110-0.289402.359201.62070K562HSPD1
    DGCR8ENSG00000128191.94154.853305197.00300-0.322903.061902.19100K562KIF1C
    DGCR8ENSG00000128191.91837.475702414.07620-0.393702.471501.59330K562KRR1
    DGCR8ENSG00000128191.95193.034904086.391800.345707.862106.56170K562MTPAP
    DGCR8ENSG00000128191.93008.418004080.74590-0.439803.197902.23520K562NAA15
    DGCR8ENSG00000128191.93629.955402739.445100.406003.782502.00720K562NUSAP1
    DGCR8ENSG00000128191.93589.987502716.340400.402203.694102.00970K562PHF6
    DGCR8ENSG00000128191.93422.910602494.549100.456306.285504.83720K562PSIP1
    DGCR8ENSG00000128191.92406.739504856.67930-1.0129023.5230021.95630K562PUS1
    DGCR8ENSG00000128191.93508.516804731.88700-0.431604.767704.00960K562RBM15
    DGCR8ENSG00000128191.95436.371304590.059400.244004.967303.75660K562SRPK2
    DGCR8ENSG00000128191.93457.653902925.310400.241102.202001.56240K562SRSF1
    DGCR8ENSG00000128191.93805.929402960.352300.362403.305802.53070K562TARDBP
    Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

    *: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
    **: "-log(0)" was displayed as "99999.99999".






    The Knockdown/knockout RNA-Seq assay for DGCR8 is not available on ENCORE database.





    21 RBPs can affect the splicing of DGCR8 :

    Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
    SEDGCR8ENSG00000128191.9chr22+200803312008043020079423200794932008223520082318-0.092000.000010.00033excludedK562SF3B4
    SEDGCR8ENSG00000128191.9chr22+200803312008043020079391200794932008223520082318-0.194000.000530.00827excludedHepG2U2AF2
    SEDGCR8ENSG00000128191.9chr22+2008031520080491200793912007949320082235200823180.282000.004180.04018includedK562AQR
    SEDGCR8ENSG00000128191.9chr22+200803152008043020079391200794932008223520082318-0.051000.004970.04634excludedK562AQR
    SEDGCR8ENSG00000128191.9chr22+200803312008043020079391200794932008223520082318-0.068000.000820.04436excludedK562EFTUD2
    SEDGCR8ENSG00000128191.9chr22+200803312008043020079391200794932008223520082318-0.215000.000000.00000excludedK562U2AF1
    SEDGCR8ENSG00000128191.9chr22+200803312008043020079391200794932008223520082318-0.374000.000000.00000excludedK562U2AF2
    SEDGCR8ENSG00000128191.9chr22+200936992009380020082234200823182009411420094559-0.074000.000220.00564excludedK562U2AF2
    SEDGCR8ENSG00000128191.9chr22+200803312008043020079391200794932008223520082318-0.088000.000140.03867excludedK562SERBP1
    A3SSDGCR8ENSG00000128191.9chr22+2007461020074844200746842007484420073209200742060.148000.000000.00000longerK562U2AF2
    A3SSDGCR8ENSG00000128191.9chr22+200803312008043020080341200804302007942320079493-0.059000.000800.04405shorterK562SF3B4
    A3SSDGCR8ENSG00000128191.9chr22+2007892720079155200789572007915520077191200777810.087000.000000.00000longerK562AQR
    A5SSDGCR8ENSG00000128191.9chr22+200771912007736620077191200773342007749820077781-0.289000.000030.00507shorterK562FXR1
    A5SSDGCR8ENSG00000128191.9chr22+200771912007736620077191200773342007749820077781-0.160000.000050.02480shorterK562EIF4G2
    RIDGCR8ENSG00000128191.9chr22+200771912007778120077191200773342007749820077781-0.155000.000060.01239excludedK562APOBEC3C
    RIDGCR8ENSG00000128191.9chr22+2007719120077781200771912007733420077498200777810.082000.010060.05652includedK562PUS1
    RIDGCR8ENSG00000128191.9chr22+200771912007778120077191200773342007749820077781-0.174000.000010.00146excludedK562EIF4G2
    RIDGCR8ENSG00000128191.9chr22+200771912007778120077191200773342007749820077781-0.132000.005150.08610excludedK562SRSF1
    RIDGCR8ENSG00000128191.9chr22+200771912007778120077191200773342007749820077781-0.193000.000330.02436excludedK562NCBP2
    RIDGCR8ENSG00000128191.9chr22+2007719120077781200771912007733420077498200777810.091000.001900.02342includedK562AGGF1
    RIDGCR8ENSG00000128191.9chr22+200771912007778120077191200773342007749820077781-0.203000.000210.00399excludedK562PRPF8
    RIDGCR8ENSG00000128191.9chr22+2007719120077781200771912007733420077498200777810.329000.000280.01042includedHepG2FTO
    RIDGCR8ENSG00000128191.9chr22+200771912007778120077191200773662007749820077781-0.099000.000060.01007excludedK562MTPAP
    RIDGCR8ENSG00000128191.9chr22+2007719120077781200771912007733420077498200777810.344000.002390.02461includedHepG2TAF15
    RIDGCR8ENSG00000128191.9chr22+200771912007778120077191200773662007749820077781-0.084000.004910.07157excludedK562U2AF1
    RIDGCR8ENSG00000128191.9chr22+200771912007778120077191200773662007749820077781-0.123000.000710.05917excludedK562XRCC6
    RIDGCR8ENSG00000128191.9chr22+200771912007778120077191200773662007749820077781-0.104000.000650.01095excludedK562U2AF2
    RIDGCR8ENSG00000128191.9chr22+200771912007778120077191200773662007749820077781-0.272000.000000.00002excludedK562EFTUD2
    RIDGCR8ENSG00000128191.9chr22+200771912007778120077191200773342007749820077781-0.178000.000290.02847excludedK562SAFB
    RIDGCR8ENSG00000128191.9chr22+200771912007778120077191200773342007749820077781-0.157000.000030.01002excludedK562PUM1
    RIDGCR8ENSG00000128191.9chr22+200771912007778120077191200773662007749820077781-0.208000.000000.00000excludedK562AQR
    RIDGCR8ENSG00000128191.9chr22+200771912007778120077191200773342007749820077781-0.245000.000000.00006excludedK562PTBP1
    RIDGCR8ENSG00000128191.9chr22+200771912007778120077191200773342007749820077781-0.411000.000000.00000excludedK562FXR1
    MXEDGCR8ENSG00000128191.9chr22+20082235200823182009369920093800200793912007949320094114200942080.238000.000000.000001includedK562U2AF1

    *: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
    **: "-log(0)" was displayed as "99999.99999".





    The Knockdown/knockout RNA-Seq assay for DGCR8 is not avaliable on ENCORE database.