AKAP8

General Information

Gene Name : AKAP8
Gene ID : ENSG00000105127.8
Essential Gene : No

Functions

Novel RBP

Localization(RBPImage: AKAP8)

Nuclei
Nucleoplasm
Mutually Exclusive from Nucleolus
Speckles
Cytoplasm
Compartment/Organelle
Mitochondria
Mitotic-Apparatus (Spindle; Centrosomes)

Domains (AlphaFold: AKAP8)

ZNF

Antibody Validation

View validation images for all AKAP8 antibodies

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	AKAP8	ENSG00000105127.8	8.98	9.16	9.07	ENCSR000AEF
HepG2	AKAP8	ENSG00000105127.8	16.75	11.58	14.16	ENCSR985KAT
K562	AKAP8	ENSG00000105127.8	12.28	9.79	11.04	ENCSR000AEO

Assays

2 Released experiments are available on ENCORE database.

Assay Type	Exp_Name	ENCODE ID	Target label	Biosample	Status	Linked Antibody	Controls	Method	Note
knockdown followed by RNA-seq	AKAP8-BGKLV32-K562	ENCSR000YYN	AKAP8	K562	Released		ENCSR143COQ	shRNA	KD% = 55.7,67.9
knockdown followed by RNA-seq	AKAP8-BGHLV27-HepG2	ENCSR958KSY	AKAP8	HepG2	Released		ENCSR246RRQ	shRNA	KD% = 66.5,62.9

eCLIP

No eCLIP experiment available

Antibody Validation

GeneName	Antibody_DCC_ID	Product_ID	Lot_ID	Phosphate	HepG2 Primary Validation	K562 Primary Validation	HepG2 Secondary Validation	K562 Secondary Validation
AKAP8	ENCAB124CAD	A301-061A	1			Released, ENCODE3	BGHLV27-5, Released, ENCODE3	BGKLV32-7, Released, ENCODE3
AKAP8	ENCAB322CRJ	A301-062A	1			Released, ENCODE4	BGHLV27-5, Released, ENCODE3

KD RNA-Seq

GeneName	Cell_Line	Method	Exp_ID	Control_ID	Sample_reps	Control_reps	KD%	Status	Project
AKAP8	K562	shRNA			BGKLV28-3,BGKLV28-4	BGKLV28-1,BGKLV28-2	38.6,46.4	NotSatisfied	ENCODE3
AKAP8	K562	shRNA	ENCSR000YYN	ENCSR143COQ	AKAP8_BGKLV32-7,AKAP8_BGKLV32-8	NT_BGKLV32-1,NT_BGKLV32-2	55.7,67.9	Released	ENCODE3
AKAP8	HepG2	shRNA			BGHLV16-5,BGHLV16-6	BGHLV16-1,BGHLV16-2		NotSatisfied	ENCODE3
AKAP8	HepG2	shRNA			BGHLV17-3,BGHLV17-4	BGHLV17-1,BGHLV17-2		NotSatisfied	ENCODE3
AKAP8	HepG2	shRNA	ENCSR958KSY	ENCSR246RRQ	AKAP8_BGHLV27-5,AKAP8_BGHLV27-6	non-target_BGHLV27-1,non-target_BGHLV27-2	66.5,62.9	Released	ENCODE3

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

AKAP8: Click to RBP Image Database

Nuclei

Nucleoplasm

Mutually Exclusive from Nucleolus

Speckles

Cytoplasm

Compartment/Organelle

Mitochondria

Mitotic-Apparatus (Spindle; Centrosomes)

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela
AKAP8	Product_ID: A301-062A Lot_ID: 1 Source: Bethyl Labs Target Name: AKAP8-human
AKAP8	Product_ID: A301-061A Lot_ID: 1 Source: Bethyl Labs Target Name: AKAP8-human

Summary
Proteins Bound to RBP RNA

RNA Targets

eCLIP assay for AKAP8 is not avaliable on ENCORE database.

Proteins bound to RNA

AKAP8 RNA is bound by 29 proteins.

eCLIP assay for AKAP8 is not avaliable on ENCORE database.

29 proteins are bound to AKAP8 RNA:

Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr19	15480900	15480986	-	3'-UTR,CDS,intron-Distal,intron-Proximal	4.13795	4.69223	K562	SF3B4
chr19	15480945	15480991	-	3'-UTR,CDS,intron-Distal,intron-Proximal	3.21132	3.72946	HepG2	PPIG
chr19	15483650	15483731	-	3'-UTR,CDS,intron-Distal,intron-Proximal	4.46619	4.81156	HepG2	SRSF1
chr19	15483122	15483178	-	3'-UTR,CDS,intron-Distal,intron-Proximal	4.39264	4.20763	HepG2	U2AF2
chr19	15480962	15481020	-	3'-UTR,CDS,intron-Distal,intron-Proximal	3.66263	5.34337	K562	AQR
chr19	15472556	15472622	-	3'-UTR,CDS,intron-Distal	4.47395	3.36385	K562	UCHL5
chr19	15472998	15473048	-	3'-UTR,CDS,intron-Distal	3.31352	3.12941	K562	UCHL5
chr19	15472552	15472617	-	3'-UTR,CDS,intron-Distal	4.18782	3.79347	HepG2	GRWD1
chr19	15472556	15472606	-	3'-UTR,CDS,intron-Distal	4.06734	3.06595	HepG2	BCLAF1
chr19	15472865	15472960	-	3'-UTR,CDS,intron-Distal,intron-Proximal	3.78535	8.17589	HepG2	PRPF8
chr19	15472475	15472546	-	3'-UTR,CDS,intron-Distal,intron-Proximal	3.32359	5.11990	K562	AQR
chr19	15480949	15480987	-	3'-UTR,CDS,intron-Distal,intron-Proximal	4.14936	4.50960	HepG2	GRWD1
chr19	15480946	15480996	-	3'-UTR,CDS,intron-Distal,intron-Proximal	3.58122	7.14018	K562	BUD13
chr19	15480916	15480962	-	3'-UTR,CDS,intron-Distal,intron-Proximal	3.63883	5.65303	HepG2	PRPF8
chr19	15483148	15483195	-	3'-UTR,CDS,intron-Distal,intron-Proximal	4.16263	6.01372	K562	AQR
chr19	15464489	15464599	-	3'-UTR,intron-Distal	3.59514	4.50550	K562	UPF1
chr19	15466015	15466063	-	3'-UTR,CDS,intron-Distal	4.54826	4.42734	K562	UCHL5
chr19	15480898	15480962	-	3'-UTR,CDS,intron-Distal,intron-Proximal	3.49211	5.11990	K562	AQR
chr19	15482778	15482823	-	3'-UTR,CDS,intron-Distal,intron-Proximal	3.32389	3.16095	HepG2	U2AF2
chr19	15490524	15490556	-	5'-UTR,CDS,intron-Distal	3.98307	4.04622	HepG2	GRWD1
chr19	15479092	15479146	-	5'-UTR,CDS,intron-Distal,intron-Proximal	3.33692	4.13112	K562	SRSF1
chr19	15478986	15479078	-	5'-UTR,CDS,intron-Distal,intron-Proximal	3.39040	7.89388	HepG2	PRPF8
chr19	15479067	15479137	-	5'-UTR,CDS,intron-Distal,intron-Proximal	3.08031	5.18023	HepG2	GRWD1
chr19	15479019	15479047	-	5'-UTR,CDS,intron-Distal,intron-Proximal	3.94234	4.89208	K562	AQR
chr19	15479051	15479090	-	5'-UTR,CDS,intron-Distal	4.22058	3.01428	K562	UCHL5
chr19	15479049	15479087	-	5'-UTR,CDS,intron-Distal	3.19987	3.39477	K562	BUD13
chr19	15479097	15479191	-	5'-UTR,CDS,intron-Distal,intron-Proximal	4.61767	4.57682	HepG2	SF3B4
chr19	15490517	15490589	-	5'-UTR,CDS,intron-Distal	3.09833	5.26571	HepG2	NCBP2
chr19	15484080	15484159	-	CDS,intron-Distal,intron-Proximal	3.87601	7.35476	HepG2	GRWD1
chr19	15487746	15487789	-	CDS,intron-Distal,intron-Proximal	3.57784	5.70176	HepG2	AQR
chr19	15485362	15485478	-	CDS,intron-Distal,intron-Proximal	4.09227	9.68077	HepG2	PRPF8
chr19	15484875	15484937	-	CDS,intron-Distal,intron-Proximal	4.28568	9.62011	K562	SF3B4
chr19	15487672	15487798	-	CDS,intron-Distal,intron-Proximal	3.49513	7.64390	K562	EFTUD2
chr19	15484573	15484638	-	CDS,intron-Distal,intron-Proximal	3.58868	4.97821	K562	BUD13
chr19	15485417	15485445	-	CDS,intron-Distal	3.69275	4.41267	HepG2	PPIG
chr19	15484552	15484638	-	CDS,intron-Distal,intron-Proximal	3.64851	9.86827	HepG2	PRPF8
chr19	15487743	15487831	-	CDS,intron-Distal,intron-Proximal	3.00612	6.00494	K562	BUD13
chr19	15484124	15484221	-	CDS,intron-Distal,intron-Proximal	4.65616	15.72959	K562	SF3B4
chr19	15484130	15484189	-	CDS,intron-Distal,intron-Proximal	3.43821	7.36655	K562	AQR
chr19	15484147	15484217	-	CDS,intron-Distal,intron-Proximal	4.25223	18.55214	HepG2	SF3B4
chr19	15487795	15487869	-	CDS,intron-Distal,intron-Proximal	3.49324	7.38298	HepG2	AQR
chr19	15485417	15485481	-	CDS,intron-Distal,intron-Proximal	4.47179	11.31344	K562	AQR
chr19	15485337	15485417	-	CDS,intron-Distal,intron-Proximal	4.37311	11.27315	K562	AQR
chr19	15484790	15484860	-	CDS,intron-Distal	3.49449	5.14253	HepG2	GRWD1
chr19	15490456	15490526	-	CDS,intron-Distal	3.30948	9.25476	HepG2	PRPF8
chr19	15484108	15484236	-	CDS,intron-Distal,intron-Proximal	3.11149	5.67855	K562	SMNDC1
chr19	15485371	15485478	-	CDS,intron-Distal,intron-Proximal	4.40103	8.92943	HepG2	AQR
chr19	15487779	15487788	-	CDS,intron-Distal,intron-Proximal	5.52516	14.28850	K562	AQR
chr19	15487738	15487792	-	CDS,intron-Distal,intron-Proximal	3.55042	9.28389	HepG2	PRPF8
chr19	15484540	15484602	-	CDS,intron-Distal,intron-Proximal	3.86388	5.51372	HepG2	EFTUD2
chr19	15484558	15484635	-	CDS,intron-Distal,intron-Proximal	4.91724	5.90930	HepG2	AQR
chr19	15483853	15483905	-	CDS,intron-Distal	3.41298	3.63043	HepG2	GRWD1
chr19	15484813	15484838	-	CDS,intron-Distal	3.75712	6.36657	K562	YBX3
chr19	15483922	15483992	-	CDS,intron-Distal,intron-Proximal	3.67081	3.73423	K562	UCHL5
chr19	15487780	15487835	-	CDS,intron-Distal,intron-Proximal	3.61201	3.02321	K562	U2AF2
chr19	15483927	15483981	-	CDS,intron-Distal,intron-Proximal	3.19472	3.80299	HepG2	GRWD1
chr19	15484147	15484208	-	CDS,intron-Distal,intron-Proximal	3.61801	6.43894	HepG2	SF3A3
chr19	15483958	15484032	-	CDS,intron-Distal,intron-Proximal	3.38980	6.27819	HepG2	PPIG
chr19	15484158	15484225	-	intron-Distal,intron-Proximal	4.22841	3.02828	HepG2	XRN2
chr19	15484515	15484548	-	intron-Distal,intron-Proximal	3.41611	3.43550	K562	AQR
chr19	15490439	15490519	-	intron-Distal	4.80843	6.08021	K562	PRPF8
chr19	15490445	15490516	-	intron-Distal	5.10659	6.94957	HepG2	CSTF2T
chr19	15488851	15488886	-	intron-Distal	4.74303	6.44072	HepG2	HNRNPM
chr19	15490414	15490493	-	intron-Distal	4.59360	6.67793	HepG2	EFTUD2
chr19	15473062	15473101	-	intron-Distal,intron-Proximal	4.86168	5.40008	K562	SF3B4
chr19	15490388	15490502	-	intron-Distal	4.43532	7.48999	K562	NONO
chr19	15482956	15483020	-	intron-Distal,intron-Proximal	4.90103	3.65355	K562	EFTUD2
chr19	15487715	15487782	-	intron-Distal,intron-Proximal	3.23177	4.98422	K562	PRPF8
chr19	15487722	15487787	-	intron-Distal,intron-Proximal	4.09038	6.87873	HepG2	EFTUD2
chr19	15489701	15489748	-	intron-Distal	5.95627	31.27285	HepG2	HNRNPM
chr19	15485293	15485375	-	intron-Distal,intron-Proximal	5.89563	7.41664	HepG2	EFTUD2
chr19	15490072	15490094	-	intron-Distal	3.35089	3.42785	HepG2	HNRNPM
chr19	15482747	15482763	-	intron-Distal,intron-Proximal	3.94556	4.52312	K562	AQR
chr19	15486918	15487007	-	intron-Distal	3.00177	3.15971	K562	ILF3
chr19	15490438	15490518	-	intron-Distal	4.45083	5.54639	K562	CSTF2T
chr19	15489382	15489444	-	intron-Distal	5.49613	12.60442	K562	HNRNPM
chr19	15479002	15479019	-	intron-Distal,intron-Proximal	3.89579	4.52312	K562	AQR
chr19	15489009	15489034	-	intron-Distal	4.16465	4.27460	K562	HNRNPM
chr19	15489001	15489033	-	intron-Distal	3.95725	3.01456	K562	EXOSC5
chr19	15488748	15488832	-	intron-Distal	3.61281	3.01619	K562	FUS
chr19	15489363	15489445	-	intron-Distal	6.10356	17.70700	HepG2	HNRNPM
chr19	15488117	15488186	-	intron-Distal	4.17089	6.40934	HepG2	HNRNPM
chr19	15490451	15490492	-	intron-Distal	3.80669	7.70675	K562	AQR
chr19	15490300	15490338	-	intron-Distal	4.88609	6.19745	HepG2	HNRNPM
chr19	15489744	15489854	-	intron-Distal	4.99656	7.60866	K562	NONO
chr19	15489699	15489757	-	intron-Distal	3.66957	5.27813	K562	EWSR1
chr19	15489634	15489732	-	intron-Distal	3.83489	3.60936	K562	FUS
chr19	15479785	15479844	-	intron-Distal,intron-Proximal	3.06526	3.26837	HepG2	HNRNPC
chr19	15487726	15487779	-	intron-Distal,intron-Proximal	5.85334	17.48131	K562	AQR
chr19	15479138	15479182	-	intron-Distal,intron-Proximal	3.81619	4.42765	K562	SF3B4
chr19	15490295	15490327	-	intron-Distal	3.52013	4.32964	K562	HNRNPM
chr19	15489511	15489591	-	intron-Distal	4.39123	9.28343	K562	HNRNPM
chr19	15490382	15490422	-	intron-Distal	4.38213	3.36105	HepG2	RBM22
chr19	15482715	15482747	-	intron-Distal,intron-Proximal	5.43098	7.63570	K562	AQR
chr19	15489758	15489785	-	intron-Distal	4.13395	4.27460	K562	HNRNPM
chr19	15489518	15489560	-	intron-Distal	4.09441	3.30664	K562	NONO
chr19	15473101	15473147	-	intron-Distal,intron-Proximal	3.69569	3.60967	K562	SF3B4
chr19	15489401	15489439	-	intron-Distal	4.01499	3.30696	K562	EXOSC5
chr19	15489502	15489549	-	intron-Distal	3.49419	6.90940	HepG2	HNRNPM
chr19	15484880	15484973	-	intron-Distal,intron-Proximal	3.50214	4.52919	HepG2	SF3B4
chr19	15487747	15487777	-	intron-Distal,intron-Proximal	4.68398	4.77100	HepG2	BUD13
chr19	15489704	15489774	-	intron-Distal	3.24973	3.14999	K562	EXOSC5
chr19	15484551	15484597	-	intron-Distal,intron-Proximal	3.83614	5.83621	K562	AQR
chr19	15490470	15490524	-	intron-Distal	3.24731	4.80460	HepG2	AQR
chr19	15489628	15489675	-	intron-Distal	4.46209	8.19743	HepG2	HNRNPM
chr19	15485167	15485264	-	intron-Distal	4.84140	7.09445	K562	NONO
chr19	15489901	15489950	-	intron-Distal	4.54842	5.31505	K562	HNRNPM
chr19	15488129	15488193	-	intron-Distal	4.62945	6.35761	K562	HNRNPM
chr19	15479337	15479410	-	intron-Distal	4.54826	5.29868	K562	UCHL5
chr19	15488039	15488110	-	intron-Distal	4.54167	5.04680	K562	HNRNPM
chr19	15488128	15488206	-	intron-Distal	4.59973	6.16396	K562	NONO
chr19	15489692	15489750	-	intron-Distal	5.19486	23.51331	K562	HNRNPM
chr19	15489628	15489678	-	intron-Distal	3.62004	7.25781	K562	HNRNPM
chr19	15490014	15490119	-	intron-Distal,intron-Proximal	3.18125	6.44311	HepG2	CSTF2T
chr19	15488634	15488690	-	intron-Distal	4.17754	3.01456	K562	EXOSC5
chr19	15484156	15484264	-	intron-Distal,intron-Proximal	3.02900	3.80339	HepG2	PRPF4
chr19	15483617	15483659	-	intron-Distal,intron-Proximal	5.18137	5.69951	K562	AQR
chr19	15488034	15488117	-	intron-Distal	5.32332	9.67630	HepG2	HNRNPM
chr19	15490492	15490524	-	intron-Distal	5.16736	11.12698	K562	AQR
chr19	15485342	15485399	-	intron-Distal,intron-Proximal	4.31174	3.45219	HepG2	RBFOX2
chr19	15484484	15484554	-	intron-Distal,intron-Proximal	4.69351	5.95597	K562	EFTUD2
chr19	15484876	15484955	-	intron-Distal,intron-Proximal	4.67896	5.56788	K562	SMNDC1
chr19	15485166	15485241	-	intron-Distal	3.24672	6.46712	HepG2	RBFOX2
chr19	15490176	15490247	-	intron-Distal	4.00987	3.21228	K562	TIA1
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

eCLIP assay for AKAP8 is not avaliable on ENCORE database.

Diffrential Expression

6,168 differentially expressed genes after Knockdown/Knockout AKAP8 protein.

48 RBPs can affect the levels of AKAP8.

6,168 differentially expressed genes after Knockdown/Knockout AKAP8 protein :

Only display 100 entries as example. Please click "View All" button to see all 6,168 entries.

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
NIPAL3	ENSG00000001461.12	499.40990	360.70400	0.46930	2.54250	1.54340	HepG2	AKAP8
SEMA3F	ENSG00000001617.7	979.27870	605.72550	0.69300	5.98650	4.48710	HepG2	AKAP8
LASP1	ENSG00000002834.13	11000.55100	7257.75440	0.59990	6.81470	5.22660	HepG2	AKAP8
DBNDD1	ENSG00000003249.9	1995.90160	1122.42490	0.83030	10.09670	8.25030	HepG2	AKAP8
SLC7A2	ENSG00000003989.12	6609.90250	10699.71050	-0.69490	9.10820	7.34080	HepG2	AKAP8
PLXND1	ENSG00000004399.8	5548.30300	3599.01620	0.62430	6.74540	5.16510	HepG2	AKAP8
KDM1A	ENSG00000004487.11	2044.29250	2636.59980	-0.36710	2.53570	1.53770	HepG2	AKAP8
RBM6	ENSG00000004534.10	4252.39480	5503.85310	-0.37220	2.81860	1.77220	HepG2	AKAP8
SKAP2	ENSG00000005020.8	615.64360	416.13730	0.56490	3.85090	2.62690	HepG2	AKAP8
LIG3	ENSG00000005156.7	609.61540	935.23490	-0.61740	5.13590	3.73260	HepG2	AKAP8
FAM214B	ENSG00000005238.15	405.74610	212.85190	0.93060	6.88670	5.29210	HepG2	AKAP8
CREBBP	ENSG00000005339.8	2330.00000	3001.64740	-0.36540	2.71280	1.68520	HepG2	AKAP8
WDR54	ENSG00000005448.12	143.14990	62.54620	1.19440	5.01190	3.62230	HepG2	AKAP8
RHBDD2	ENSG00000005486.12	1099.90620	666.49690	0.72260	4.07170	2.81420	HepG2	AKAP8
ITGAL	ENSG00000005844.13	34.84230	88.04250	-1.33740	4.31220	3.02120	HepG2	AKAP8
ITGA3	ENSG00000005884.13	436.78100	46.98090	3.21670	30.35630	27.38150	HepG2	AKAP8
ZFX	ENSG00000005889.11	805.53810	1241.35660	-0.62390	5.54640	4.09170	HepG2	AKAP8
ASB4	ENSG00000005981.8	196.89380	47.19310	2.06070	15.23790	13.02570	HepG2	AKAP8
GDE1	ENSG00000006007.7	3796.06100	2307.18090	0.71830	8.76630	7.02190	HepG2	AKAP8
TMEM132A	ENSG00000006118.10	816.77430	542.82570	0.58930	4.30420	3.01490	HepG2	AKAP8
CX3CL1	ENSG00000006210.6	1709.50980	3362.05620	-0.97580	6.83120	5.24170	HepG2	AKAP8
SPATA20	ENSG00000006282.15	1567.86100	1011.69330	0.63190	4.54700	3.22350	HepG2	AKAP8
TNFRSF12A	ENSG00000006327.9	1364.85300	750.25780	0.86320	9.71660	7.90490	HepG2	AKAP8
MAP3K9	ENSG00000006432.11	1119.98900	774.22000	0.53260	4.05100	2.79620	HepG2	AKAP8
BAIAP2L1	ENSG00000006453.9	1640.51780	1226.08740	0.42000	2.97260	1.89740	HepG2	AKAP8
PHTF2	ENSG00000006576.12	493.78440	313.02460	0.65750	4.13850	2.87020	HepG2	AKAP8
PROM1	ENSG00000007062.7	693.46740	513.12510	0.43440	2.72890	1.69720	HepG2	AKAP8
PAX6	ENSG00000007372.16	79.40470	33.10430	1.26210	3.56820	2.39190	HepG2	AKAP8
RHBDF1	ENSG00000007384.11	618.13640	355.41480	0.79830	6.42550	4.88020	HepG2	AKAP8
BAIAP3	ENSG00000007516.9	513.25130	248.20860	1.04800	7.26820	5.63980	HepG2	AKAP8
PIGQ	ENSG00000007541.10	314.93650	169.17770	0.89640	5.50650	4.05960	HepG2	AKAP8
SPAG9	ENSG00000008294.16	3454.19050	4561.42150	-0.40110	3.16930	2.05660	HepG2	AKAP8
ST3GAL1	ENSG00000008513.10	1026.76640	1802.20780	-0.81170	9.78030	7.96020	HepG2	AKAP8
IL32	ENSG00000008517.12	6655.39210	3715.61380	0.84080	12.01380	10.02850	HepG2	AKAP8
RPS20	ENSG00000008988.5	4551.34970	6787.21630	-0.57650	6.06750	4.55750	HepG2	AKAP8
POMT2	ENSG00000009830.7	613.14170	438.24530	0.48440	2.78180	1.74210	HepG2	AKAP8
MLXIPL	ENSG00000009950.11	1963.22660	3184.17460	-0.69770	2.32050	1.36220	HepG2	AKAP8
STARD3NL	ENSG00000010270.9	645.58880	454.73220	0.50550	3.19770	2.08100	HepG2	AKAP8
CD9	ENSG00000010278.7	434.59590	263.70970	0.72060	4.89320	3.52090	HepG2	AKAP8
NCAPD2	ENSG00000010292.8	1928.62100	2857.80930	-0.56730	5.71920	4.24850	HepG2	AKAP8
GIPR	ENSG00000010310.4	218.90110	102.62630	1.09280	6.09730	4.58310	HepG2	AKAP8
SEMA3G	ENSG00000010319.2	650.72260	891.27780	-0.45380	3.11360	2.01130	HepG2	AKAP8
IDS	ENSG00000010404.13	2606.61850	1125.92340	1.21100	21.56880	18.98850	HepG2	AKAP8
SCMH1	ENSG00000010803.12	889.07020	1397.35630	-0.65230	6.15330	4.62990	HepG2	AKAP8
FYN	ENSG00000010810.13	807.92450	498.39320	0.69680	5.82750	4.34460	HepG2	AKAP8
LYPLA2	ENSG00000011009.6	1981.70760	1314.27210	0.59240	3.89520	2.66300	HepG2	AKAP8
TSPAN9	ENSG00000011105.7	1060.69370	1631.37270	-0.62110	3.57300	2.39560	HepG2	AKAP8
MBTD1	ENSG00000011258.11	1103.18660	1537.97600	-0.47940	3.72140	2.52240	HepG2	AKAP8
PLAUR	ENSG00000011422.7	137.40020	56.13830	1.29120	5.90720	4.41810	HepG2	AKAP8
ANLN	ENSG00000011426.6	507.08710	1124.95070	-1.14960	6.77030	5.18640	HepG2	AKAP8
RABGAP1	ENSG00000011454.12	1052.93370	1561.54740	-0.56860	4.92810	3.55190	HepG2	AKAP8
MAP4K3	ENSG00000011566.10	2994.36920	4566.28340	-0.60880	3.28500	2.15650	HepG2	AKAP8
BRCA1	ENSG00000012048.15	116.98870	206.73140	-0.82140	3.58700	2.40690	HepG2	AKAP8
PRICKLE3	ENSG00000012211.8	165.58960	98.46870	0.74980	2.82970	1.78120	HepG2	AKAP8
EXTL3	ENSG00000012232.4	964.90720	726.16730	0.41000	2.48330	1.49480	HepG2	AKAP8
NR1H4	ENSG00000012504.9	260.72490	848.33710	-1.70210	21.59390	19.00640	HepG2	AKAP8
PSMC4	ENSG00000013275.3	1319.61280	1021.65500	0.36910	2.37840	1.40940	HepG2	AKAP8
MAN2B2	ENSG00000013288.4	690.00910	495.35850	0.47800	2.89500	1.83460	HepG2	AKAP8
MVP	ENSG00000013364.14	2427.70260	956.29070	1.34400	25.51910	22.76960	HepG2	AKAP8
PGM3	ENSG00000013375.11	1806.81840	2331.77520	-0.36800	2.48210	1.49410	HepG2	AKAP8
ANGEL1	ENSG00000013523.5	541.95900	754.83980	-0.47800	3.15320	2.04360	HepG2	AKAP8
DNASE1L1	ENSG00000013563.9	441.64540	266.24720	0.73000	4.95720	3.57570	HepG2	AKAP8
GPRC5A	ENSG00000013588.5	239.29780	126.36100	0.92120	4.83160	3.46620	HepG2	AKAP8
TACC3	ENSG00000013810.14	307.58490	584.26070	-0.92560	8.28820	6.58850	HepG2	AKAP8
CAPN1	ENSG00000014216.11	2363.64050	1559.88780	0.59950	5.88400	4.39720	HepG2	AKAP8
MTMR11	ENSG00000014914.15	185.05960	111.99380	0.72450	2.97200	1.89720	HepG2	AKAP8
CHDH	ENSG00000016391.6	2094.05670	2993.22210	-0.51540	4.88700	3.51640	HepG2	AKAP8
GLT8D1	ENSG00000016864.12	895.43890	1310.94050	-0.54990	4.38410	3.08210	HepG2	AKAP8
SRCIN1	ENSG00000017373.11	495.52830	773.21450	-0.64190	3.60150	2.42000	HepG2	AKAP8
PHLDB1	ENSG00000019144.12	967.13370	708.07110	0.44970	2.91970	1.85480	HepG2	AKAP8
CYP24A1	ENSG00000019186.5	349.06520	128.25980	1.44430	12.90760	10.87130	HepG2	AKAP8
SYT13	ENSG00000019505.3	72.26930	12.74930	2.50290	6.18350	4.65830	HepG2	AKAP8
CD74	ENSG00000019582.10	2263.70570	1627.80710	0.47570	3.91770	2.68230	HepG2	AKAP8
NCDN	ENSG00000020129.11	362.39760	242.49930	0.57950	2.97070	1.89640	HepG2	AKAP8
CYP3A43	ENSG00000021461.12	12.84680	51.48780	-2.00280	4.57900	3.25020	HepG2	AKAP8
BIRC3	ENSG00000023445.9	190.71170	73.89180	1.36780	8.16820	6.47490	HepG2	AKAP8
ABCC2	ENSG00000023839.6	9500.85850	12056.75560	-0.34370	2.66010	1.64160	HepG2	AKAP8
DEPDC1	ENSG00000024526.12	131.68890	314.64700	-1.25660	3.72940	2.52950	HepG2	AKAP8
TOMM34	ENSG00000025772.7	2753.90500	1094.27590	1.33140	25.86020	23.10020	HepG2	AKAP8
RTEL1-TNFRSF6B	ENSG00000026036.16	410.31150	201.70970	1.02430	3.02370	1.93720	HepG2	AKAP8
FAS	ENSG00000026103.15	178.53710	87.62250	1.02680	4.99800	3.61020	HepG2	AKAP8
RNASET2	ENSG00000026297.11	5039.57480	7126.40450	-0.49990	5.20550	3.79130	HepG2	AKAP8
VRK2	ENSG00000028116.12	483.46620	339.29240	0.51080	2.88050	1.82260	HepG2	AKAP8
POU2F2	ENSG00000028277.16	40.68090	16.12890	1.33460	2.35060	1.38680	HepG2	AKAP8
BAK1	ENSG00000030110.8	553.78140	375.76330	0.55940	3.50420	2.34030	HepG2	AKAP8
FUT8	ENSG00000033170.12	626.94780	238.21550	1.39600	17.29480	14.96740	HepG2	AKAP8
UHRF1	ENSG00000034063.9	126.12570	268.63660	-1.09080	5.57040	4.11040	HepG2	AKAP8
TMSB10	ENSG00000034510.4	10885.46060	5139.92770	1.08250	20.12290	17.65330	HepG2	AKAP8
TIMP2	ENSG00000035862.8	6296.88260	1853.03200	1.76460	48.07700	44.65850	HepG2	AKAP8
USP2	ENSG00000036672.11	279.16760	156.36430	0.83610	4.77790	3.42350	HepG2	AKAP8
VCAN	ENSG00000038427.11	1365.31200	1034.85490	0.39970	2.73760	1.70370	HepG2	AKAP8
CDH1	ENSG00000039068.14	587.59330	874.44380	-0.57350	4.36080	3.06260	HepG2	AKAP8
DNAH5	ENSG00000039139.9	125.21080	20.28650	2.62570	14.69030	12.51850	HepG2	AKAP8
FAM65A	ENSG00000039523.13	1512.33480	1040.51830	0.53940	4.46320	3.15040	HepG2	AKAP8
RAI14	ENSG00000039560.9	1545.40350	1023.94670	0.59370	4.99590	3.60900	HepG2	AKAP8
PQLC2	ENSG00000040487.8	296.49690	174.67480	0.76320	4.30870	3.01840	HepG2	AKAP8
PARP3	ENSG00000041880.10	788.99630	499.58910	0.65920	5.19280	3.77950	HepG2	AKAP8
PHF15	ENSG00000043143.16	478.71420	347.93950	0.46020	2.33340	1.37260	HepG2	AKAP8
PHKA2	ENSG00000044446.7	5882.16990	9026.53770	-0.61780	7.57310	5.90960	HepG2	AKAP8
HSPA5	ENSG00000044574.7	12675.26780	15975.73630	-0.33390	2.34160	1.37930	HepG2	AKAP8
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

48 RBPs can affect the gene expression of AKAP8 :

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
AKAP8	ENSG00000105127.4	790.42010	619.43200	0.35160	3.47660	2.80820	HepG2	ACO1
AKAP8	ENSG00000105127.4	315.94910	531.28980	-0.74980	5.62270	4.15950	HepG2	AKAP8
AKAP8	ENSG00000105127.4	693.63360	513.34680	0.43410	2.44540	1.84270	HepG2	EIF4A3
AKAP8	ENSG00000105127.4	1256.28930	991.64610	0.34120	3.93930	3.24340	HepG2	ETF1
AKAP8	ENSG00000105127.4	761.01310	518.19370	0.55430	4.01060	3.18740	HepG2	FXR1
AKAP8	ENSG00000105127.4	643.15100	480.57000	0.42030	2.33340	1.71990	HepG2	G3BP1
AKAP8	ENSG00000105127.4	753.35160	486.92550	0.62950	5.34190	4.39470	HepG2	HNRNPK
AKAP8	ENSG00000105127.4	857.31980	518.37570	0.72570	6.57060	5.57100	HepG2	MAGOH
AKAP8	ENSG00000105127.4	767.68530	521.23660	0.55850	3.67130	2.95420	HepG2	MATR3
AKAP8	ENSG00000105127.4	716.33690	533.48180	0.42510	2.42900	1.83320	HepG2	NCBP2
AKAP8	ENSG00000105127.4	646.15850	468.54360	0.46360	4.37980	3.64580	HepG2	PCBP1
AKAP8	ENSG00000105127.4	507.68510	630.93960	-0.31360	2.49590	1.90280	HepG2	PUS1
AKAP8	ENSG00000105127.4	1251.73130	828.82840	0.59470	9.19660	8.37750	HepG2	RBM22
AKAP8	ENSG00000105127.4	741.99140	530.58440	0.48370	4.67280	4.00370	HepG2	NELFE
AKAP8	ENSG00000105127.4	708.33530	494.14370	0.51940	5.35140	4.52930	HepG2	RECQL
AKAP8	ENSG00000105127.4	567.22780	371.46340	0.61060	5.00830	4.20930	HepG2	RPS19
AKAP8	ENSG00000105127.4	680.97070	455.95340	0.57860	4.17170	3.19740	HepG2	RPS2
AKAP8	ENSG00000105127.4	480.00700	349.68690	0.45690	3.81210	3.07690	HepG2	SAFB2
AKAP8	ENSG00000105127.4	1079.57500	750.78120	0.52390	3.41630	2.66420	HepG2	SF3A3
AKAP8	ENSG00000105127.4	671.88220	496.38110	0.43670	3.80290	3.12750	HepG2	SF3B4
AKAP8	ENSG00000105127.4	550.65550	407.77720	0.43330	3.97670	3.22790	HepG2	SMN1
AKAP8	ENSG00000105127.4	738.18990	518.10290	0.51070	5.30150	4.70070	HepG2	SRSF1
AKAP8	ENSG00000105127.4	827.64200	696.13660	0.24950	2.25020	1.67870	HepG2	SRSF5
AKAP8	ENSG00000105127.4	666.30580	445.60090	0.58030	3.87620	3.09710	HepG2	SUPV3L1
AKAP8	ENSG00000105127.4	549.64300	381.49630	0.52670	4.37500	3.77570	HepG2	TIAL1
AKAP8	ENSG00000105127.4	512.64670	384.97470	0.41310	3.35340	2.74580	HepG2	TRIM56
AKAP8	ENSG00000105127.4	1082.04520	637.74310	0.76260	8.61050	7.49660	HepG2	U2AF1
AKAP8	ENSG00000105127.4	1244.56320	692.31760	0.84600	2.28290	1.39780	HepG2	U2AF2
AKAP8	ENSG00000105127.4	377.71210	263.24510	0.52080	3.05300	2.25770	HepG2	UCHL5
AKAP8	ENSG00000105127.4	574.44000	438.64450	0.38900	2.17410	1.52530	HepG2	XRN2
AKAP8	ENSG00000105127.4	607.66230	763.08280	-0.32860	2.54960	2.00000	K562	AGGF1
AKAP8	ENSG00000105127.4	618.56390	838.54330	-0.43900	3.33650	2.23480	K562	AKAP8
AKAP8	ENSG00000105127.4	1552.81300	1022.56140	0.60260	6.73780	5.88720	K562	AQR
AKAP8	ENSG00000105127.4	544.38160	692.60120	-0.34740	2.48410	1.73860	K562	CPSF6
AKAP8	ENSG00000105127.4	1431.18080	1065.24570	0.42590	6.23130	5.30880	K562	DDX47
AKAP8	ENSG00000105127.4	756.80420	478.17400	0.66230	5.79880	4.44640	K562	EFTUD2
AKAP8	ENSG00000105127.4	539.41740	338.74080	0.67110	3.30300	2.19610	K562	EIF3A
AKAP8	ENSG00000105127.4	647.26370	357.14160	0.85780	8.49620	7.10680	K562	EIF3G
AKAP8	ENSG00000105127.4	774.01810	478.11940	0.69490	7.51060	6.16220	K562	EIF4A3
AKAP8	ENSG00000105127.4	1569.53070	1261.25660	0.31540	3.46260	2.41490	K562	EIF4G2
AKAP8	ENSG00000105127.4	571.06420	769.61140	-0.43050	3.19810	2.28370	K562	FIP1L1
AKAP8	ENSG00000105127.4	759.14540	497.22600	0.61040	7.45640	6.52730	K562	FXR1
AKAP8	ENSG00000105127.4	745.36640	1043.46880	-0.48540	4.28720	3.30300	K562	HSPD1
AKAP8	ENSG00000105127.4	757.09740	462.68240	0.71040	8.09230	6.61970	K562	MAGOH
AKAP8	ENSG00000105127.4	587.34140	461.72630	0.34710	2.25910	1.43270	K562	MATR3
AKAP8	ENSG00000105127.4	617.46420	411.65180	0.58480	4.80340	3.50660	K562	PCBP2
AKAP8	ENSG00000105127.4	859.59930	465.32080	0.88530	9.77810	8.36160	K562	PRPF8
AKAP8	ENSG00000105127.4	583.64810	449.53350	0.37660	2.60340	1.95610	K562	PTBP1
AKAP8	ENSG00000105127.4	545.07110	787.40580	-0.53070	4.20840	3.56010	K562	PUS1
AKAP8	ENSG00000105127.4	645.72490	430.98630	0.58320	5.01110	3.84000	K562	RBM22
AKAP8	ENSG00000105127.4	648.38150	474.65250	0.44990	3.27080	2.09250	K562	SAFB
AKAP8	ENSG00000105127.4	955.21770	440.70550	1.11590	19.61780	17.73620	K562	SRSF1
AKAP8	ENSG00000105127.4	397.11300	290.57820	0.45050	2.34530	1.38780	K562	SRSF4
AKAP8	ENSG00000105127.4	711.42390	534.27490	0.41300	3.28030	2.38650	K562	SYNCRIP
AKAP8	ENSG00000105127.4	741.09970	445.99500	0.73250	7.31960	6.10900	K562	TARDBP
AKAP8	ENSG00000105127.4	1018.54220	820.25550	0.31230	3.47110	2.53170	K562	WDR43
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

The Knockdown/knockout RNA-Seq assay for AKAP8 is not available on ENCORE database.

12 RBPs can affect the splicing of AKAP8 :

Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	p-value	FDR	is_included	Cell Line	Affected by RBP
SE	AKAP8	ENSG00000105127.4	chr19	-	15479877	15480035	15479045	15479133	15480956	15480990	-0.15200	0.00000	0.00000	excluded	K562	SRSF1
SE	AKAP8	ENSG00000105127.4	chr19	-	15479877	15480035	15479045	15479133	15480956	15480990	-0.11100	0.00261	0.07559	excluded	K562	PRPF8
SE	AKAP8	ENSG00000105127.4	chr19	-	15479877	15480035	15479045	15479133	15480956	15480990	-0.14100	0.00020	0.07330	excluded	K562	XRN2
SE	AKAP8	ENSG00000105127.4	chr19	-	15479877	15480035	15479045	15479133	15480956	15480990	-0.10400	0.00342	0.07921	excluded	K562	AKAP8L
SE	AKAP8	ENSG00000105127.4	chr19	-	15479877	15480035	15479045	15479133	15480956	15480990	-0.12000	0.00086	0.06865	excluded	K562	XRCC6
SE	AKAP8	ENSG00000105127.4	chr19	-	15479877	15480035	15479045	15479133	15480956	15481103	0.16800	0.00014	0.00227	included	K562	AQR
SE	AKAP8	ENSG00000105127.4	chr19	-	15479877	15480035	15479045	15479133	15480956	15480990	-0.21200	0.00000	0.00034	excluded	K562	FXR1
SE	AKAP8	ENSG00000105127.4	chr19	-	15479877	15480035	15479045	15479133	15480956	15480990	-0.20400	0.00004	0.00164	excluded	K562	U2AF1
SE	AKAP8	ENSG00000105127.4	chr19	-	15479877	15480035	15479045	15479133	15480956	15480990	-0.06100	0.00552	0.09505	excluded	HepG2	SRSF1
SE	AKAP8	ENSG00000105127.4	chr19	-	15479877	15480035	15479045	15479133	15480956	15480990	-0.11600	0.00000	0.00082	excluded	K562	SRSF7
SE	AKAP8	ENSG00000105127.4	chr19	-	15479877	15480035	15479045	15479133	15480956	15480990	-0.17200	0.00362	0.05597	excluded	K562	U2AF2
SE	AKAP8	ENSG00000105127.4	chr19	-	15479877	15480035	15479045	15479133	15480956	15480990	-0.12000	0.00004	0.01761	excluded	K562	SAFB
A3SS	AKAP8	ENSG00000105127.4	chr19	-	15471658	15471881	15471658	15471789	15472539	15472633	0.12200	0.00013	0.01037	longer	K562	SF3B4
A3SS	AKAP8	ENSG00000105127.4	chr19	-	15479045	15479171	15479045	15479133	15479877	15480035	0.19300	0.00450	0.02635	longer	K562	AQR
A3SS	AKAP8	ENSG00000105127.4	chr19	-	15471658	15471881	15471658	15471789	15472539	15472633	0.10700	0.00000	0.00002	longer	K562	AQR
A3SS	AKAP8	ENSG00000105127.4	chr19	-	15469777	15469956	15469777	15469873	15471658	15471789	0.18900	0.00000	0.00000	longer	K562	AQR

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

AKAP8

General Information

Functions

Localization(RBPImage: AKAP8)

Domains (AlphaFold: AKAP8)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

eCLIP assay for AKAP8 is not avaliable on ENCORE database.

29 proteins are bound to AKAP8 RNA:

eCLIP assay for AKAP8 is not avaliable on ENCORE database.

Diffrential Expression

6,168 differentially expressed genes after Knockdown/Knockout AKAP8 protein :

48 RBPs can affect the gene expression of AKAP8 :

The Knockdown/knockout RNA-Seq assay for AKAP8 is not available on ENCORE database.

12 RBPs can affect the splicing of AKAP8 :

The Knockdown/knockout RNA-Seq assay for AKAP8 is not avaliable on ENCORE database.