PSMC4

General Information

Gene Name       : PSMC4
Gene ID             : ENSG00000013275.7
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: PSMC4)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878PSMC4ENSG00000013275.755.2778.3666.81ENCSR000AEF
HepG2PSMC4ENSG00000013275.7123.9993.98108.98ENCSR985KAT
K562PSMC4ENSG00000013275.7123.29129.02126.16ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for PSMC4 is not avaliable on ENCORE database.



Proteins bound to RNA
  • PSMC4 RNA is bound by 21 proteins.  







eCLIP assay for PSMC4 is not avaliable on ENCORE database.





21 proteins are bound to PSMC4 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr194048729540487338+3'-UTR3.871115.17284K562TIA1
chr194048720240487282+3'-UTR,CDS3.7364512.50846K562PABPC4
chr194048727040487295+3'-UTR5.305676.97910HepG2PCBP2
chr194048721340487278+3'-UTR4.592755.13929K562PCBP1
chr194048729840487335+3'-UTR5.5119610.44987K562PABPC4
chr194048729540487332+3'-UTR3.847194.03740HepG2PCBP2
chr194048719740487270+3'-UTR,CDS3.7487613.83446HepG2PCBP2
chr194047709640477146+5'-UTR,CDS,intron-Proximal3.6348815.13050K562DDX3X
chr194048048940480509+CDS3.700203.34184HepG2GRWD1
chr194048623340486240+CDS3.117363.12941K562UCHL5
chr194047802340478085+CDS,intron-Proximal3.560865.75231K562AQR
chr194048627940486336+CDS4.419383.39686HepG2G3BP1
chr194048616840486224+CDS,intron-Proximal3.353345.81258K562AQR
chr194048710140487145+CDS4.459733.11282HepG2G3BP1
chr194048627840486356+CDS3.780003.79230K562SND1
chr194048021240480247+CDS3.304503.50696K562BUD13
chr194048599140486019+CDS3.347413.05161HepG2PPIG
chr194048576340485832+CDS3.808183.24162HepG2G3BP1
chr194047805440478087+CDS3.659276.71596K562UCHL5
chr194048598740486027+CDS3.031183.17744HepG2GRWD1
chr194048632840486359+CDS4.094596.61895K562ZNF622
chr194047712640477145+CDS3.496853.17151K562UCHL5
chr194048061340480675+CDS,intron-Proximal3.328507.39396HepG2BUD13
chr194047808740478146+CDS3.951758.82687K562UCHL5
chr194048622440486248+CDS3.347413.64266HepG2PPIG
chr194048574040485821+CDS5.145566.20365K562SND1
chr194048604140486101+CDS,intron-Proximal3.931313.86479HepG2PRPF8
chr194047802140478096+CDS,intron-Proximal4.130745.59977HepG2AQR
chr194048606040486212+CDS,intron-Proximal3.749476.01432HepG2PRPF4
chr194047805440478144+CDS3.043366.56336K562YBX3
chr194048601440486051+CDS4.407843.96931HepG2G3BP1
chr194048064140480693+CDS,intron-Proximal4.383454.69071HepG2GRWD1
chr194047809040478147+CDS4.201774.59151HepG2G3BP1
chr194048610640486197+CDS,intron-Proximal3.332274.23709HepG2AQR
chr194048050940480540+CDS4.169563.79347HepG2GRWD1
chr194047835240478420+CDS,intron-Proximal3.617665.73766K562YBX3
chr194048657240486591+CDS3.271415.04943K562ZNF622
chr194047804940478134+CDS,intron-Proximal3.858189.30456K562RPS3
chr194048572540485820+CDS4.418389.25286K562PUM2
chr194047729040477316+intron-Distal4.172063.11721K562AQR
chr194048160140481677+intron-Distal3.805623.06194K562ILF3
chr194048611840486181+intron-Proximal4.028503.82050HepG2SF3B4
chr194048606440486178+intron-Proximal4.679905.84281K562GTF2F1
chr194048074040480782+intron-Proximal4.072514.45914HepG2PRPF8
chr194048608640486168+intron-Proximal4.214184.14518HepG2GTF2F1
chr194047714740477225+intron-Proximal4.676739.04436K562AQR
chr194048636340486406+intron-Proximal3.892344.49024K562AQR
chr194047714540477189+intron-Proximal4.550983.63072HepG2AQR
chr194048058040480637+intron-Proximal4.744453.91589K562SF3B4
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for PSMC4 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for PSMC4 is not available on ENCORE database.

  • 91 RBPs can affect the levels of PSMC4.  








The Knockdown/knockout RNA-Seq assay for PSMC4 is not available on ENCORE database.





91 RBPs can affect the gene expression of PSMC4 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
PSMC4ENSG00000013275.33519.784701670.260301.0753016.7403015.54330HepG2AKAP1
PSMC4ENSG00000013275.31319.612801021.655000.369102.378401.40940HepG2AKAP8
PSMC4ENSG00000013275.32009.810201543.063000.381203.605902.93260HepG2BOP1
PSMC4ENSG00000013275.32021.542701312.949300.622507.116905.91860HepG2CIRBP
PSMC4ENSG00000013275.31669.54960791.546601.0766010.189508.75270HepG2CNOT7
PSMC4ENSG00000013275.32455.769301889.896000.377806.067405.18550HepG2CELF1
PSMC4ENSG00000013275.31426.979801129.816000.336803.515502.21230HepG2DDX1
PSMC4ENSG00000013275.3968.761901341.10080-0.469203.941302.28350HepG2DDX28
PSMC4ENSG00000013275.32502.491301599.825600.645407.279606.30920HepG2DDX3X
PSMC4ENSG00000013275.31591.84660958.315500.732008.832107.29510HepG2EEF2
PSMC4ENSG00000013275.31053.79430798.867800.399502.878201.74870HepG2EFTUD2
PSMC4ENSG00000013275.31515.497701920.43630-0.341602.713701.90610HepG2EIF4G2
PSMC4ENSG00000013275.31062.895001357.05780-0.352502.744801.65620HepG2ESF1
PSMC4ENSG00000013275.31969.341501473.431100.418403.351802.59410HepG2FXR1
PSMC4ENSG00000013275.31890.914101366.539900.468503.803103.02680HepG2G3BP1
PSMC4ENSG00000013275.31101.40200692.631300.669107.142805.71870HepG2GEMIN5
PSMC4ENSG00000013275.31145.251601605.94670-0.487803.856503.11200HepG2GPKOW
PSMC4ENSG00000013275.31531.305501867.51620-0.286403.388202.36820HepG2HNRNPA2B1
PSMC4ENSG00000013275.31658.461302031.24890-0.292502.389001.71920HepG2HNRNPF
PSMC4ENSG00000013275.31773.850001384.407200.357502.852702.14290HepG2HNRNPK
PSMC4ENSG00000013275.31185.381601532.57800-0.370602.748302.12070HepG2HNRNPLL
PSMC4ENSG00000013275.32413.389401388.957200.7970011.245509.98190HepG2IGF2BP2
PSMC4ENSG00000013275.31001.375601397.24210-0.480603.096002.02660HepG2KHSRP
PSMC4ENSG00000013275.32351.288801473.947900.673707.853706.76230HepG2MAGOH
PSMC4ENSG00000013275.32615.208301482.109700.8192010.173709.02370HepG2MATR3
PSMC4ENSG00000013275.31124.71740814.149600.466102.276901.32080HepG2METAP2
PSMC4ENSG00000013275.3914.173301562.87230-0.773705.796904.36850HepG2MTPAP
PSMC4ENSG00000013275.32047.921301516.950500.432903.414902.71470HepG2NCBP2
PSMC4ENSG00000013275.31479.186001054.118700.488703.006801.51300HepG2NKRF
PSMC4ENSG00000013275.3854.728401358.87100-0.668907.596006.39680HepG2NSUN2
PSMC4ENSG00000013275.3796.006101102.28460-0.469605.874804.83120HepG2PPIL4
PSMC4ENSG00000013275.32678.899101923.458600.477806.203205.35820HepG2PUF60
PSMC4ENSG00000013275.32450.442702041.868800.263104.681703.95280HepG2PUM1
PSMC4ENSG00000013275.32735.388002040.357100.422806.056105.07630HepG2PUM2
PSMC4ENSG00000013275.31763.162501507.396800.226001.877601.34810HepG2QKI
PSMC4ENSG00000013275.32436.673801982.883800.297203.829303.24560HepG2RBM22
PSMC4ENSG00000013275.31458.98840756.971600.9466017.5010016.15190HepG2RPS19
PSMC4ENSG00000013275.3942.827301100.59850-0.223202.070901.50060HepG2SAFB2
PSMC4ENSG00000013275.3958.95990759.704800.335902.153001.32000HepG2SERBP1
PSMC4ENSG00000013275.32377.947301693.915700.489303.531402.76600HepG2SF3A3
PSMC4ENSG00000013275.31006.704201516.99120-0.591606.572305.52280HepG2SF3B1
PSMC4ENSG00000013275.31480.027301844.36380-0.317504.876003.98490HepG2SLBP
PSMC4ENSG00000013275.31892.898501283.518000.5604011.3886010.22170HepG2SMN1
PSMC4ENSG00000013275.3691.568901687.90370-1.2873012.7413011.08020HepG2SNRNP70
PSMC4ENSG00000013275.32563.605501512.523900.7611024.0837022.98910HepG2SRSF1
PSMC4ENSG00000013275.32167.213001899.174300.190402.051601.50260HepG2SRSF5
PSMC4ENSG00000013275.3891.932501230.51430-0.464307.280706.46140HepG2SRSF9
PSMC4ENSG00000013275.32252.294801944.454600.211902.453401.96480HepG2SSB
PSMC4ENSG00000013275.32651.095502159.850900.295605.364904.55040HepG2SUCLG1
PSMC4ENSG00000013275.31069.912401359.50130-0.345601.952301.46730HepG2TAF15
PSMC4ENSG00000013275.31104.985801493.59730-0.434803.892103.04860HepG2TARDBP
PSMC4ENSG00000013275.31631.811901088.650100.583802.381001.39090HepG2TBRG4
PSMC4ENSG00000013275.31026.558901249.21150-0.283202.338801.56790HepG2TIA1
PSMC4ENSG00000013275.31575.194901200.987300.391204.421703.82030HepG2TIAL1
PSMC4ENSG00000013275.32198.566601353.186700.700109.336108.17170HepG2U2AF1
PSMC4ENSG00000013275.31620.85740874.323400.890402.635401.67220HepG2U2AF2
PSMC4ENSG00000013275.31309.432001502.24160-0.198201.938501.33650HepG2UPF1
PSMC4ENSG00000013275.32173.603301450.359300.5836012.8574011.70690HepG2UTP3
PSMC4ENSG00000013275.31736.059001262.510300.459402.768201.71370HepG2XRCC6
PSMC4ENSG00000013275.31613.828801215.673800.408607.236906.23510HepG2ZC3H8
PSMC4ENSG00000013275.33288.786201652.181900.9931056.5594054.91170HepG2ZNF622
PSMC4ENSG00000013275.32371.222902948.19480-0.314202.569301.39920K562ABCF1
PSMC4ENSG00000013275.32522.436202116.635800.252903.295602.68630K562AGGF1
PSMC4ENSG00000013275.32718.027302202.444000.303401.989101.43350K562AKAP8L
PSMC4ENSG00000013275.35013.793303193.360400.6507010.311609.28810K562AQR
PSMC4ENSG00000013275.31806.617702243.14640-0.312203.196401.56540K562CEBPZ
PSMC4ENSG00000013275.31944.201901547.720100.328902.723401.45410K562CIRBP
PSMC4ENSG00000013275.33024.692302662.829300.183702.022001.44970K562DDX47
PSMC4ENSG00000013275.32894.521802370.059400.288303.729302.69180K562DKC1
PSMC4ENSG00000013275.3956.812601320.64240-0.464904.342702.63130K562DNAJC21
PSMC4ENSG00000013275.32405.723501714.921400.488203.460102.01730K562EEF2
PSMC4ENSG00000013275.32214.373602971.04940-0.424107.638806.53140K562EIF2S2
PSMC4ENSG00000013275.31700.688801114.889200.6091010.809409.23010K562EIF3G
PSMC4ENSG00000013275.32022.982101601.089300.337302.945702.09910K562EIF4A3
PSMC4ENSG00000013275.33252.727804062.40440-0.320704.537903.34700K562EIF4G2
PSMC4ENSG00000013275.31435.057001802.92070-0.329202.613301.78290K562FMR1
PSMC4ENSG00000013275.31077.602501528.13570-0.503904.510503.31690K562FTO
PSMC4ENSG00000013275.32628.044201665.062900.6583015.9782014.63290K562FXR1
PSMC4ENSG00000013275.3552.34590982.78560-0.831307.156105.90630K562G3BP2
PSMC4ENSG00000013275.32143.018302584.96200-0.270502.496501.47590K562HNRNPA1
PSMC4ENSG00000013275.31351.536201806.15360-0.418304.482503.74150K562HNRNPC
PSMC4ENSG00000013275.31941.367301442.106500.428803.734602.27620K562HNRNPK
PSMC4ENSG00000013275.32050.376501444.832200.504904.024302.69110K562IGF2BP2
PSMC4ENSG00000013275.32023.155301517.702800.414604.526303.44450K562MAGOH
PSMC4ENSG00000013275.32703.509002237.418800.272902.447001.45700K562MAK16
PSMC4ENSG00000013275.31828.765002222.04720-0.281004.032103.07150K562MTPAP
PSMC4ENSG00000013275.32181.116902468.92880-0.178802.546101.82670K562NSUN2
PSMC4ENSG00000013275.32507.163401354.762400.887904.983703.54460K562PABPN1
PSMC4ENSG00000013275.31999.354902768.01340-0.469304.290303.25360K562PCBP3
PSMC4ENSG00000013275.31695.541802123.14230-0.324503.249702.37680K562POLR2G
PSMC4ENSG00000013275.32612.404001612.244000.696209.584408.18380K562PRPF8
PSMC4ENSG00000013275.32079.830201474.600100.496006.755605.75380K562PTBP1
PSMC4ENSG00000013275.33815.363904714.18270-0.305203.495402.28660K562PUM1
PSMC4ENSG00000013275.33443.729704619.39720-0.423707.723206.09260K562PUM2
PSMC4ENSG00000013275.33016.115502184.302300.465405.309204.58910K562PUS1
PSMC4ENSG00000013275.32589.747002128.205400.283103.210202.57890K562RBM15
PSMC4ENSG00000013275.31943.933801413.550800.459604.837903.68760K562RBM22
PSMC4ENSG00000013275.32172.261001642.041300.403602.892002.05470K562RPS19
PSMC4ENSG00000013275.32394.512801238.743800.950804.500102.85040K562SF1
PSMC4ENSG00000013275.31766.961801021.655100.7903012.2091010.33250K562SF3B4
PSMC4ENSG00000013275.32345.141601422.965200.720703.018201.71520K562SNRNP200
PSMC4ENSG00000013275.31898.684401445.684900.393104.280803.40680K562SRSF1
PSMC4ENSG00000013275.32184.275402780.70610-0.348303.032401.59910K562SSRP1
PSMC4ENSG00000013275.32830.517902129.592400.410405.583904.40900K562SYNCRIP
PSMC4ENSG00000013275.3611.35870964.69750-0.658103.318501.66430K562TAF15
PSMC4ENSG00000013275.31888.161801462.943900.368002.264201.61990K562TARDBP
PSMC4ENSG00000013275.31807.673001385.263900.383903.445302.19960K562TRA2A
PSMC4ENSG00000013275.32211.341502617.85480-0.243503.340202.55510K562UPF1
PSMC4ENSG00000013275.32981.922703597.61580-0.270802.374901.58470K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for PSMC4 is not available on ENCORE database.





3 RBPs can affect the splicing of PSMC4 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
A3SSPSMC4ENSG00000013275.3chr19+4047823340478462404783684047846240478034404781510.244000.000080.00068longerK562AQR
RIPSMC4ENSG00000013275.3chr19+4048619240486624404861924048636140486568404866240.064000.000000.00001includedHepG2SF3A3
RIPSMC4ENSG00000013275.3chr19+4048597640486361404859764048605340486192404863610.064000.000040.00224includedHepG2UCHL5
RIPSMC4ENSG00000013275.3chr19+4048619240486624404861924048636140486568404866240.055000.000000.00000includedK562AQR
RIPSMC4ENSG00000013275.3chr19+4048597640486361404859764048605340486192404863610.053000.000000.00000includedK562AQR

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for PSMC4 is not avaliable on ENCORE database.