PHLDB1

General Information

Gene Name       : PHLDB1
Gene ID             : ENSG00000019144.18
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: PHLDB1)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878PHLDB1ENSG00000019144.180.020.020.02ENCSR000AEF
HepG2PHLDB1ENSG00000019144.189.578.238.90ENCSR985KAT
K562PHLDB1ENSG00000019144.1810.2510.9110.58ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for PHLDB1 is not avaliable on ENCORE database.



Proteins bound to RNA
  • PHLDB1 RNA is bound by 17 proteins.  







eCLIP assay for PHLDB1 is not avaliable on ENCORE database.





17 proteins are bound to PHLDB1 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr11118518660118518767+3'-UTR,CDS3.713035.42720K562UCHL5
chr11118528419118528505+3'-UTR3.394514.75109K562UPF1
chr11118516347118516416+3'-UTR,CDS,intron-Distal,intron-Proximal3.347433.20886K562PRPF8
chr11118527993118528059+3'-UTR3.169996.32251K562UPF1
chr11118520824118520899+3'-UTR,CDS,intron-Proximal3.836733.06853K562LIN28B
chr11118518642118518773+3'-UTR,CDS,intron-Proximal4.2842612.47570HepG2PPIG
chr11118528505118528568+3'-UTR4.553915.24231K562UPF1
chr11118514887118514945+3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal4.815226.35567HepG2PRPF8
chr11118516515118516575+3'-UTR,CDS,intron-Proximal3.116568.00684HepG2PRPF8
chr11118516541118516596+3'-UTR,CDS,intron-Proximal4.267203.85435K562PRPF8
chr11118514671118514792+5'-UTR,CDS,intron-Distal,intron-Proximal4.314044.50924HepG2SF3B4
chr11118506139118506244+5'-UTR,CDS3.932978.98325HepG2PPIG
chr11118506104118506253+5'-UTR,CDS,intron-Proximal3.033763.40321HepG2GRWD1
chr11118506162118506244+5'-UTR,CDS3.685223.40453HepG2SRSF1
chr11118512918118512988+CDS,intron-Distal,intron-Proximal4.621415.36996HepG2PCBP2
chr11118501917118502019+CDS,intron-Distal,intron-Proximal3.308413.64266HepG2PPIG
chr11118499364118499441+CDS,intron-Distal,intron-Proximal4.819794.13847K562AQR
chr11118502123118502196+CDS,intron-Distal4.543454.38106HepG2PPIG
chr11118503827118503937+intron-Distal4.039333.65854HepG2RBFOX2
chr11118479076118479240+intron-Distal5.2298315.94588K562AGGF1
chr11118479458118479586+intron-Distal5.9614412.92204K562AGGF1
chr11118505136118505191+intron-Distal4.011284.83406HepG2QKI
chr11118512766118512821+intron-Distal4.070303.09122HepG2PTBP1
chr11118503881118503941+intron-Distal5.7143310.31535HepG2QKI
chr11118515638118515694+intron-Distal4.684865.79972HepG2RBFOX2
chr11118491853118491939+intron-Distal3.861475.00478HepG2PCBP2
chr11118516024118516069+intron-Distal,intron-Proximal4.213233.50006HepG2SF3B4
chr11118506009118506096+intron-Distal,intron-Proximal5.7007112.50933HepG2SF3A3
chr11118512844118512951+intron-Distal,intron-Proximal4.140085.16181K562PTBP1
chr11118512857118512961+intron-Distal,intron-Proximal3.354873.45713HepG2PTBP1
chr11118492689118492812+intron-Distal4.533195.44904K562TARDBP
chr11118490648118490759+intron-Distal4.461484.85626K562TARDBP
chr11118479134118479240+intron-Distal4.705907.47869K562HNRNPL
chr11118505419118505521+intron-Distal3.635807.58331K562PTBP1
chr11118503828118503881+intron-Distal5.8516213.63922HepG2QKI
chr11118515694118515746+intron-Distal4.640154.97791HepG2RBFOX2
chr11118478938118478998+intron-Distal4.868605.18780K562AGGF1
chr11118490759118490830+intron-Distal4.078864.13603K562TARDBP
chr11118505287118505375+intron-Distal5.293388.17201HepG2PCBP2
chr11118482066118482143+intron-Distal4.399073.55787K562PTBP1
chr11118504544118504589+intron-Distal4.560064.05848HepG2QKI
chr11118480419118480498+intron-Distal3.946673.59673K562HNRNPL
chr11118505420118505499+intron-Distal4.737016.42900HepG2PTBP1
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for PHLDB1 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for PHLDB1 is not available on ENCORE database.

  • 108 RBPs can affect the levels of PHLDB1.  








The Knockdown/knockout RNA-Seq assay for PHLDB1 is not available on ENCORE database.





108 RBPs can affect the gene expression of PHLDB1 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
PHLDB1ENSG00000019144.12666.96710871.31620-0.385602.407001.52780HepG2ABCF1
PHLDB1ENSG00000019144.12960.38840660.846500.539208.158107.22680HepG2ACO1
PHLDB1ENSG00000019144.12967.13370708.071100.449702.919701.85480HepG2AKAP8
PHLDB1ENSG00000019144.12818.79980663.956300.302302.592301.84700HepG2AKAP8L
PHLDB1ENSG00000019144.12671.36300439.749100.610304.561003.56470HepG2ASCC1
PHLDB1ENSG00000019144.121347.56360845.539500.6723013.0723011.77560HepG2AUH
PHLDB1ENSG00000019144.121254.99940902.250400.476002.987901.97370HepG2CCAR1
PHLDB1ENSG00000019144.12801.70260431.743700.892806.232205.08440HepG2CNOT7
PHLDB1ENSG00000019144.12977.41930562.483000.7971013.3742012.16920HepG2CELF1
PHLDB1ENSG00000019144.12262.84540412.61640-0.650604.702503.50250HepG2DDX24
PHLDB1ENSG00000019144.12747.84000509.091500.554703.926703.19260HepG2DDX3X
PHLDB1ENSG00000019144.12859.63500466.600400.881403.517302.65870HepG2DDX55
PHLDB1ENSG00000019144.12690.34700437.417900.658204.758803.96840HepG2DDX6
PHLDB1ENSG00000019144.12407.54050632.25250-0.633607.227706.23050HepG2DKC1
PHLDB1ENSG00000019144.12538.90570432.427000.317502.100601.47930HepG2DNAJC21
PHLDB1ENSG00000019144.12573.19740428.647500.419104.041303.28320HepG2DNAJC2
PHLDB1ENSG00000019144.12604.20200420.403400.523203.332302.68580HepG2EIF2S1
PHLDB1ENSG00000019144.12579.50970396.428000.547703.336902.34950HepG2EIF3D
PHLDB1ENSG00000019144.12822.64950452.392500.862606.619605.58750HepG2EIF4B
PHLDB1ENSG00000019144.121338.22460970.802100.463006.715805.84650HepG2ETF1
PHLDB1ENSG00000019144.121553.45440879.799200.820108.855307.57350HepG2FIP1L1
PHLDB1ENSG00000019144.12697.59690450.075300.632103.908302.58780HepG2FUS
PHLDB1ENSG00000019144.12912.67340468.851800.9609011.192709.89480HepG2FXR1
PHLDB1ENSG00000019144.12847.23760434.854100.9621010.541009.28320HepG2G3BP1
PHLDB1ENSG00000019144.12654.74020438.879600.577003.954802.73330HepG2GNB2L1
PHLDB1ENSG00000019144.12640.52610485.616600.399302.488401.82790HepG2HNRNPC
PHLDB1ENSG00000019144.12682.89270440.503600.632405.149104.21830HepG2HNRNPK
PHLDB1ENSG00000019144.12522.89570764.69570-0.548404.131103.37740HepG2HNRNPLL
PHLDB1ENSG00000019144.12633.98570482.405000.394103.658502.97100HepG2HNRNPU
PHLDB1ENSG00000019144.12583.79480441.993100.401302.096601.50020HepG2IGF2BP2
PHLDB1ENSG00000019144.12591.36700492.758500.263102.002501.36690HepG2ILF2
PHLDB1ENSG00000019144.121603.98580952.994800.751007.086105.74520HepG2LARP4
PHLDB1ENSG00000019144.12614.80530469.016100.390402.071001.49990HepG2MAGOH
PHLDB1ENSG00000019144.12771.15550471.618000.709305.532404.66480HepG2MATR3
PHLDB1ENSG00000019144.12771.36510414.875200.894605.875604.38930HepG2METAP2
PHLDB1ENSG00000019144.12915.37750482.708500.9231010.018008.85690HepG2NCBP2
PHLDB1ENSG00000019144.12988.96380428.684601.205908.070706.17130HepG2NONO
PHLDB1ENSG00000019144.12469.12420678.04510-0.531403.884803.00200HepG2NSUN2
PHLDB1ENSG00000019144.12770.00090394.743500.963804.315503.19190HepG2PABPC1
PHLDB1ENSG00000019144.12668.64290429.797100.637504.897703.94740HepG2PABPC4
PHLDB1ENSG00000019144.12675.80850477.482200.501105.235804.11950HepG2PARN
PHLDB1ENSG00000019144.12713.81490434.543200.7160010.102509.05990HepG2PCBP1
PHLDB1ENSG00000019144.12502.89600359.705400.483302.119301.40820HepG2PRPF8
PHLDB1ENSG00000019144.12963.76900442.174701.1240025.7900024.44510HepG2PTBP1
PHLDB1ENSG00000019144.12840.81290572.570400.554204.908804.14230HepG2PUF60
PHLDB1ENSG00000019144.121129.11510607.766800.8935020.1476018.84550HepG2PUM1
PHLDB1ENSG00000019144.12794.80930607.348900.388002.644601.98870HepG2PUM2
PHLDB1ENSG00000019144.12898.25520478.863300.9074014.3685013.10090HepG2QKI
PHLDB1ENSG00000019144.121140.11550865.538000.397402.660001.81700HepG2RBM15
PHLDB1ENSG00000019144.121285.49240811.408900.6637011.0034010.12040HepG2RBM22
PHLDB1ENSG00000019144.12554.93580434.607800.352502.124001.52720HepG2RBM25
PHLDB1ENSG00000019144.12975.37230385.774301.3381025.8782024.31220HepG2RPS19
PHLDB1ENSG00000019144.12803.94540478.224600.749307.060305.82090HepG2RPS2
PHLDB1ENSG00000019144.12496.38970756.90090-0.608605.206204.25950HepG2SF3B1
PHLDB1ENSG00000019144.12708.30920460.341700.621607.383406.49280HepG2SF3B4
PHLDB1ENSG00000019144.12821.68020370.017801.150903.397901.75210HepG2SFPQ
PHLDB1ENSG00000019144.12929.17720500.968000.8911020.0370018.54870HepG2SMN1
PHLDB1ENSG00000019144.12666.28750420.046500.665503.150902.12140HepG2SMNDC1
PHLDB1ENSG00000019144.121076.01630916.453000.231502.047301.59610HepG2SRFBP1
PHLDB1ENSG00000019144.121078.36640565.279600.9317019.8439018.37300HepG2SRSF5
PHLDB1ENSG00000019144.12516.54670390.923100.401903.226302.63950HepG2SRSF9
PHLDB1ENSG00000019144.12218.38480795.69190-1.8653052.7803051.23400HepG2SSB
PHLDB1ENSG00000019144.121249.83380642.921600.9589024.8795023.32110HepG2SUCLG1
PHLDB1ENSG00000019144.12834.92190464.424100.846106.353405.39070HepG2SUPV3L1
PHLDB1ENSG00000019144.12537.94490311.245000.789305.048803.76230HepG2TFIP11
PHLDB1ENSG00000019144.12619.22520468.698100.401702.988802.47200HepG2TIAL1
PHLDB1ENSG00000019144.12636.63970472.940000.428704.168903.50500HepG2TRIM56
PHLDB1ENSG00000019144.12854.29500559.308600.611004.156103.05930HepG2TUFM
PHLDB1ENSG00000019144.121155.81190752.558300.618906.027705.11710HepG2U2AF1
PHLDB1ENSG00000019144.121992.58090395.723802.3320013.4910011.23580HepG2U2AF2
PHLDB1ENSG00000019144.12420.08170274.302300.614803.415802.57680HepG2UCHL5
PHLDB1ENSG00000019144.12750.11980452.068400.730505.125103.70940HepG2XRCC6
PHLDB1ENSG00000019144.12309.06910457.17670-0.564802.713901.99600HepG2XRN2
PHLDB1ENSG00000019144.121134.38160813.037400.480408.198007.38570HepG2ZNF622
PHLDB1ENSG00000019144.121287.34130975.630300.399903.101601.79690K562ABCF1
PHLDB1ENSG00000019144.121083.70460575.914000.911904.398202.20070K562ADAR
PHLDB1ENSG00000019144.12311.83230478.85550-0.618806.162403.86830K562AKAP1
PHLDB1ENSG00000019144.12773.90840973.29480-0.330702.196701.66350K562AQR
PHLDB1ENSG00000019144.12788.65760601.835600.389903.338801.86900K562BCCIP
PHLDB1ENSG00000019144.12771.78050581.606100.408003.883502.73120K562BCLAF1
PHLDB1ENSG00000019144.12774.85000563.934500.458303.274802.10700K562CCAR1
PHLDB1ENSG00000019144.121198.58440949.168000.336503.071001.81990K562CCDC124
PHLDB1ENSG00000019144.121419.502401024.659600.470102.240101.30390K562CNOT7
PHLDB1ENSG00000019144.121438.680301101.930500.384604.607703.15390K562CPEB4
PHLDB1ENSG00000019144.12731.68890588.120100.315001.974301.30320K562CPSF6
PHLDB1ENSG00000019144.12669.58800441.234900.601605.891304.26920K562CSTF2
PHLDB1ENSG00000019144.122353.780001511.925000.6385011.356209.46370K562CELF1
PHLDB1ENSG00000019144.121368.398601084.193800.335803.593302.21170K562DDX21
PHLDB1ENSG00000019144.12885.30800631.306900.487703.684802.11310K562DHX30
PHLDB1ENSG00000019144.12666.55550889.31720-0.416003.353702.37790K562DKC1
PHLDB1ENSG00000019144.12831.67360606.427300.455603.446701.93780K562DNAJC21
PHLDB1ENSG00000019144.12843.54220570.086900.565202.566301.69030K562EFTUD2
PHLDB1ENSG00000019144.12658.11800506.852300.376702.418501.65040K562EIF4A3
PHLDB1ENSG00000019144.121209.07910854.131000.501305.680403.82150K562EXOSC5
PHLDB1ENSG00000019144.12422.22220586.32280-0.473702.889801.73610K562FKBP4
PHLDB1ENSG00000019144.12727.42200527.101300.464604.409803.66990K562FXR1
PHLDB1ENSG00000019144.12131.77110255.15780-0.953405.232404.18870K562G3BP2
PHLDB1ENSG00000019144.12895.19750561.488900.672807.307206.01670K562GPKOW
PHLDB1ENSG00000019144.12812.71770586.817900.469703.726101.34480K562GRWD1
PHLDB1ENSG00000019144.121236.24790675.048000.8728013.8498012.59680K562HNRNPC
PHLDB1ENSG00000019144.12685.90760950.80200-0.471103.869402.93140K562HSPD1
PHLDB1ENSG00000019144.12823.23650569.413800.531704.181502.34250K562KHDRBS1
PHLDB1ENSG00000019144.12612.32900436.216000.489203.940002.92990K562MAGOH
PHLDB1ENSG00000019144.12595.53970435.308400.452103.472502.42360K562MATR3
PHLDB1ENSG00000019144.12706.52910548.084700.366202.406701.59300K562METAP2
PHLDB1ENSG00000019144.12487.44810688.68960-0.498602.639001.78080K562NAA15
PHLDB1ENSG00000019144.121657.764401110.980300.5773014.8487013.30990K562NSUN2
PHLDB1ENSG00000019144.121438.09120984.396200.546703.133001.81110K562PABPC1
PHLDB1ENSG00000019144.12557.31560388.097000.522003.806002.65890K562PCBP2
PHLDB1ENSG00000019144.12767.19200605.271800.341902.118001.33690K562PSIP1
PHLDB1ENSG00000019144.12868.05380423.822301.0342017.6492016.04290K562PTBP1
PHLDB1ENSG00000019144.12517.24410819.60870-0.664105.938405.18020K562PUS1
PHLDB1ENSG00000019144.12825.40720406.313501.0224014.7226012.60610K562RBM22
PHLDB1ENSG00000019144.12598.12650396.140500.594304.568602.64430K562RBM34
PHLDB1ENSG00000019144.121523.624101096.241200.474806.942705.69560K562SF3A3
PHLDB1ENSG00000019144.12398.98150265.284600.588704.465803.36940K562SF3B4
PHLDB1ENSG00000019144.12901.32780621.148700.537004.752303.05960K562SLBP
PHLDB1ENSG00000019144.12732.47850523.584600.484303.692302.45990K562SRFBP1
PHLDB1ENSG00000019144.121661.113201123.121600.5645012.4471010.64430K562SRPK2
PHLDB1ENSG00000019144.12620.74010415.536000.578903.058501.93860K562SRSF4
PHLDB1ENSG00000019144.121269.32820967.545500.391604.664703.12800K562SRSF7
PHLDB1ENSG00000019144.121141.32850420.481001.4405028.2640025.51590K562TARDBP
PHLDB1ENSG00000019144.12622.61070405.610900.618105.812304.55900K562TIA1
PHLDB1ENSG00000019144.12842.53440582.158200.533202.994602.01770K562TIAL1
PHLDB1ENSG00000019144.12573.29010398.110300.526003.809402.49390K562TRA2A
PHLDB1ENSG00000019144.12406.28640255.411400.669605.431904.31100K562U2AF2
PHLDB1ENSG00000019144.121966.324001512.639000.378303.575101.96450K562UBE2L3
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for PHLDB1 is not available on ENCORE database.





2 RBPs can affect the splicing of PHLDB1 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEPHLDB1ENSG00000019144.12chr11+1185153641185154091185147891185148921185160731185163680.699000.000000.00000includedHepG2U2AF1
SEPHLDB1ENSG00000019144.12chr11+1185056391185057691185028371185030131185061101185062660.416000.000000.00000includedHepG2U2AF2
A5SSPHLDB1ENSG00000019144.12chr11+1185147891185154091185147891185148921185160731185163680.447000.000010.00219longerHepG2U2AF1
RIPHLDB1ENSG00000019144.12chr11+118514789118515409118514789118514892118515364118515409-0.593000.008670.07070excludedHepG2U2AF1

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for PHLDB1 is not avaliable on ENCORE database.