VRK2

General Information

Gene Name       : VRK2
Gene ID             : ENSG00000028116.17
Essential Gene : No

Functions

Localization

Domains (AlphaFold: VRK2)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878VRK2ENSG00000028116.1757.4653.0755.27ENCSR000AEF
HepG2VRK2ENSG00000028116.1712.8927.3520.12ENCSR985KAT
K562VRK2ENSG00000028116.1730.1933.0931.64ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for VRK2 is not avaliable on ENCORE database.



Proteins bound to RNA
  • VRK2 RNA is bound by 11 proteins.  







eCLIP assay for VRK2 is not avaliable on ENCORE database.





11 proteins are bound to VRK2 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr25835028258350355+3'-UTR,CDS3.261623.55800HepG2BCLAF1
chr25827593658275983+3'-UTR,5'-UTR,CDS,intron-Proximal4.227573.77802HepG2U2AF2
chr25838661458386715+3'-UTR,CDS3.277324.47973K562YBX3
chr25827596558276054+3'-UTR,5'-UTR,CDS,intron-Proximal4.879146.73676K562UCHL5
chr25835893958359080+3'-UTR,CDS,intron-Proximal3.422564.93175HepG2GRWD1
chr25836226858362320+3'-UTR,CDS,intron-Proximal4.566614.12401HepG2U2AF2
chr25827598458276045+5'-UTR,CDS,intron-Proximal3.094594.14618K562ZNF622
chr25827402758274097+5'-UTR,intron-Distal,intron-Proximal5.156365.58036HepG2EFTUD2
chr25831122358311272+5'-UTR,CDS,intron-Proximal4.848815.23259HepG2BCLAF1
chr25827389958274004+5'-UTR,intron-Distal,intron-Proximal3.352675.21590K562DDX3X
chr25829924458299382+intron-Distal3.733863.68839K562KHSRP
chr25830141158301523+intron-Distal4.577095.41654K562KHSRP
chr25836110158361161+intron-Distal3.930233.90026K562KHSRP
chr25830879058308935+intron-Distal4.685676.07567K562KHSRP
chr25832343858323508+intron-Distal3.077093.07751K562KHSRP
chr25827613558276237+intron-Distal,intron-Proximal4.4453110.06297K562KHSRP
chr25832286658322928+intron-Distal4.584266.07567K562KHSRP
chr25832187858321964+intron-Distal3.138554.74253K562KHSRP
chr25832298458323121+intron-Distal3.078407.02852K562KHSRP
chr25832197958322037+intron-Distal4.044283.71397K562KHSRP
chr25829916358299244+intron-Distal4.138553.24603K562KHSRP
chr25832447158324531+intron-Distal4.157533.66668K562KHSRP
chr25832312158323195+intron-Distal3.535324.70224K562KHSRP
chr25835995658360038+intron-Distal3.972203.37631K562HNRNPL
chr25832178558321923+intron-Distal5.275058.69609K562EXOSC5
chr25827872258278800+intron-Distal3.455413.91876HepG2U2AF2
chr25832323958323310+intron-Distal4.412775.62258K562KHSRP
chr25832598058326047+intron-Distal3.745613.26999K562KHSRP
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for VRK2 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for VRK2 is not available on ENCORE database.

  • 91 RBPs can affect the levels of VRK2.  








The Knockdown/knockout RNA-Seq assay for VRK2 is not available on ENCORE database.





91 RBPs can affect the gene expression of VRK2 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
VRK2ENSG00000028116.12632.14770336.392800.9100014.6912013.52420HepG2ACO1
VRK2ENSG00000028116.12276.66110379.83490-0.457302.379101.45200HepG2ADAR
VRK2ENSG00000028116.12895.76730408.138001.1340012.4704011.42320HepG2AKAP1
VRK2ENSG00000028116.12483.46620339.292400.510802.880501.82260HepG2AKAP8
VRK2ENSG00000028116.12439.94950337.992900.380202.566301.82390HepG2AKAP8L
VRK2ENSG00000028116.12231.92260531.44540-1.196308.837007.49690HepG2CNOT7
VRK2ENSG00000028116.12377.77190585.21700-0.631508.343307.16270HepG2DAZAP1
VRK2ENSG00000028116.12577.56990408.323400.500202.785802.01060HepG2DDX55
VRK2ENSG00000028116.12288.77890403.71170-0.483402.699201.69850HepG2DDX5
VRK2ENSG00000028116.12248.01050368.89790-0.572803.546502.44390HepG2DHX30
VRK2ENSG00000028116.12253.23790379.09590-0.582105.109304.26660HepG2DNAJC2
VRK2ENSG00000028116.12228.19940322.85440-0.500602.257201.71670HepG2EIF2S1
VRK2ENSG00000028116.12453.82980278.477100.704504.755203.59420HepG2EIF3D
VRK2ENSG00000028116.12254.32440356.78740-0.488402.152801.58610HepG2EIF4A3
VRK2ENSG00000028116.12742.93110577.240200.364002.889902.03750HepG2EIF4G1
VRK2ENSG00000028116.12309.83130552.97940-0.835708.187006.81780HepG2EIF4G2
VRK2ENSG00000028116.12560.64630387.156000.534102.811202.03370HepG2FIP1L1
VRK2ENSG00000028116.12255.47070451.25930-0.820802.880101.84330HepG2FTO
VRK2ENSG00000028116.12258.80460510.73370-0.980708.122107.06690HepG2GPKOW
VRK2ENSG00000028116.12292.43170386.14120-0.401001.951101.39710HepG2HNRNPA1
VRK2ENSG00000028116.12373.03070562.15010-0.591706.018405.01450HepG2HNRNPF
VRK2ENSG00000028116.12452.51350338.165300.420102.148201.52740HepG2HNRNPK
VRK2ENSG00000028116.12292.84110533.12740-0.8644012.3436011.01360HepG2HNRNPL
VRK2ENSG00000028116.12291.30830487.39910-0.742603.635102.92320HepG2HNRNPLL
VRK2ENSG00000028116.12363.95950267.113100.446202.351101.47310HepG2HNRNPM
VRK2ENSG00000028116.12248.27600426.66990-0.781208.142107.14180HepG2HNRNPU
VRK2ENSG00000028116.12356.85690553.55900-0.633405.698804.69700HepG2IGF2BP1
VRK2ENSG00000028116.12548.28150318.563600.783202.390701.48420HepG2IGF2BP3
VRK2ENSG00000028116.12578.77760362.136800.676404.520903.73210HepG2MATR3
VRK2ENSG00000028116.12231.39090496.99980-1.102907.644306.00340HepG2MTPAP
VRK2ENSG00000028116.12269.91150432.14460-0.679004.454903.51020HepG2NSUN2
VRK2ENSG00000028116.12267.63660380.55570-0.507803.538202.71510HepG2PPIL4
VRK2ENSG00000028116.12522.51140307.731700.763708.756307.89420HepG2PTBP1
VRK2ENSG00000028116.12351.10660553.90430-0.657705.955405.12430HepG2PUF60
VRK2ENSG00000028116.12255.64930333.27670-0.382601.825401.30170HepG2QKI
VRK2ENSG00000028116.121100.43540394.816101.4787014.3175012.82970HepG2RAVER1
VRK2ENSG00000028116.12597.09640393.592700.601205.502604.34270HepG2RBM15
VRK2ENSG00000028116.12928.46860582.377900.672809.338608.51450HepG2RBM22
VRK2ENSG00000028116.12481.82920302.471700.671605.490204.57010HepG2RBM25
VRK2ENSG00000028116.12549.55240342.474100.682206.819606.03620HepG2NELFE
VRK2ENSG00000028116.12414.90360318.971100.379302.258801.69520HepG2RECQL
VRK2ENSG00000028116.12243.45490387.96230-0.672303.334302.29680HepG2RPS10
VRK2ENSG00000028116.12333.87310533.30590-0.675704.123003.14670HepG2RPS3A
VRK2ENSG00000028116.12520.77900311.633800.740705.161804.12050HepG2RRP9
VRK2ENSG00000028116.12211.54110379.96910-0.844908.589907.54740HepG2SAFB2
VRK2ENSG00000028116.12513.36960346.033400.569003.160202.43910HepG2SF3A3
VRK2ENSG00000028116.12245.45030482.45100-0.975006.213805.19110HepG2SF3B1
VRK2ENSG00000028116.12483.11560320.384800.592505.148704.38410HepG2SF3B4
VRK2ENSG00000028116.12377.53310531.02090-0.492204.960304.06360HepG2SLBP
VRK2ENSG00000028116.12909.24810657.768600.467005.597804.95440HepG2SRFBP1
VRK2ENSG00000028116.12489.42310334.413800.549304.442203.87780HepG2SRSF1
VRK2ENSG00000028116.12772.63650519.055900.573803.593102.43810HepG2SRSF3
VRK2ENSG00000028116.12402.20880552.28830-0.457503.893603.08840HepG2SRSF7
VRK2ENSG00000028116.12415.98360272.064700.612505.496404.76430HepG2SRSF9
VRK2ENSG00000028116.12405.58100571.08870-0.493704.732404.09740HepG2SSB
VRK2ENSG00000028116.12881.66950621.961500.503306.067605.21170HepG2SUCLG1
VRK2ENSG00000028116.12411.47000300.588300.452903.011802.43080HepG2TAF15
VRK2ENSG00000028116.12284.69810474.96140-0.738405.643104.66300HepG2TARDBP
VRK2ENSG00000028116.12374.44510276.195300.439002.570601.76240HepG2TIA1
VRK2ENSG00000028116.12269.04550414.59410-0.623804.860704.23600HepG2TIAL1
VRK2ENSG00000028116.12319.90870418.29540-0.386902.660402.10460HepG2TRIM56
VRK2ENSG00000028116.12601.35330331.179600.860507.533406.50280HepG2U2AF1
VRK2ENSG00000028116.12503.57530277.368800.860302.192801.32670HepG2U2AF2
VRK2ENSG00000028116.12208.74740372.25340-0.834504.333003.06050HepG2UPF2
VRK2ENSG00000028116.12562.97510296.280300.9260012.7830011.63720HepG2UTP3
VRK2ENSG00000028116.12325.54640477.66420-0.553102.875101.75150HepG2XPO5
VRK2ENSG00000028116.12679.29200434.264000.645403.993702.72130HepG2XRCC6
VRK2ENSG00000028116.12255.89840400.14600-0.645003.476002.66870HepG2XRN2
VRK2ENSG00000028116.12496.47720337.508400.556705.671504.96120HepG2ZNF622
VRK2ENSG00000028116.12904.374701164.41440-0.364604.280603.60140K562AGGF1
VRK2ENSG00000028116.12833.227601211.60800-0.540105.791204.82480K562AKAP8L
VRK2ENSG00000028116.12772.692701353.12940-0.8083010.713009.67020K562AQR
VRK2ENSG00000028116.12583.33700755.16370-0.372503.380202.31370K562BCLAF1
VRK2ENSG00000028116.12568.43370871.85010-0.617103.050701.92750K562CNOT7
VRK2ENSG00000028116.121940.698301274.853500.6061013.4314012.10540K562DDX47
VRK2ENSG00000028116.12510.05670712.67930-0.482604.938903.01430K562DDX6
VRK2ENSG00000028116.12417.63600681.08860-0.705606.176804.76840K562EFTUD2
VRK2ENSG00000028116.12615.44200772.04130-0.327103.012101.73990K562EIF2S1
VRK2ENSG00000028116.12944.08910767.492500.298702.176701.46510K562EIF3G
VRK2ENSG00000028116.12590.61500734.37760-0.314302.004701.30300K562EIF4A3
VRK2ENSG00000028116.12491.46830661.31440-0.428203.845302.44750K562EIF4B
VRK2ENSG00000028116.121111.44520808.815000.458502.811502.09670K562G3BP2
VRK2ENSG00000028116.12904.629101293.52300-0.515905.421904.36000K562GRSF1
VRK2ENSG00000028116.12634.251101152.14860-0.8612013.6071011.14630K562HNRNPL
VRK2ENSG00000028116.12722.29040942.40810-0.383803.699002.66610K562HNRNPU
VRK2ENSG00000028116.121628.827601174.010900.472304.516203.50550K562HSPD1
VRK2ENSG00000028116.12699.68810978.86450-0.484403.211102.07630K562IGF2BP2
VRK2ENSG00000028116.121157.783901440.50350-0.315202.974002.02120K562MBNL1
VRK2ENSG00000028116.12665.29660915.99080-0.461302.619001.66770K562PCBP2
VRK2ENSG00000028116.12346.51560574.60550-0.729706.103204.68220K562PSIP1
VRK2ENSG00000028116.121372.573501786.58510-0.380303.327802.43470K562PUF60
VRK2ENSG00000028116.12821.242601201.71080-0.549205.167804.45400K562PUS1
VRK2ENSG00000028116.12989.417701170.78000-0.242801.947601.43470K562RBM15
VRK2ENSG00000028116.12374.93010524.24270-0.483603.355302.26310K562RCC2
VRK2ENSG00000028116.121006.05400675.190200.575204.730003.65930K562RPS19
VRK2ENSG00000028116.12717.16040498.556600.524403.488102.35330K562RPS3
VRK2ENSG00000028116.12733.37070945.51330-0.366603.650802.72200K562SF3A3
VRK2ENSG00000028116.12553.06570841.71630-0.605904.503703.40360K562SF3B4
VRK2ENSG00000028116.12351.86000980.30840-1.4782013.9220012.33310K562SRSF1
VRK2ENSG00000028116.12751.14790593.671100.339302.524901.74240K562SYNCRIP
VRK2ENSG00000028116.12709.09290992.28490-0.484802.930602.20300K562TARDBP
VRK2ENSG00000028116.12388.26120587.13490-0.596704.712303.40050K562TRIM56
VRK2ENSG00000028116.12797.765701016.07310-0.349003.975703.12790K562UPF1
VRK2ENSG00000028116.121096.01470904.069000.277702.277001.50280K562WDR43
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for VRK2 is not available on ENCORE database.





9 RBPs can affect the splicing of VRK2 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEVRK2ENSG00000028116.12chr2+583622755836233458358942583590635836680058366967-0.114000.001310.02617excludedK562SF3B4
SEVRK2ENSG00000028116.12chr2+5838188858381937583734505837360958386483583870550.140000.001200.08736includedK562XRCC6
SEVRK2ENSG00000028116.12chr2+583120155831208558311223583112735831547558315581-0.086000.005320.04891excludedK562AQR
SEVRK2ENSG00000028116.12chr2+583818885838193758373450583736095838648358387006-0.128000.000030.00060excludedK562AQR
SEVRK2ENSG00000028116.12chr2+583818885838193758373450583736095838648358387006-0.091000.001280.02093excludedK562PUS1
SEVRK2ENSG00000028116.12chr2+5838188858381937583734505837360958386483583870550.174000.000510.02776includedHepG2SFPQ
SEVRK2ENSG00000028116.12chr2+583134735831356158312015583120855831547558315581-0.112000.004500.07500excludedK562U2AF1
SEVRK2ENSG00000028116.12chr2+583818885838193758373450583736095838648358387006-0.064000.002140.08154excludedHepG2SF3B4
SEVRK2ENSG00000028116.12chr2+5828548658285623582759615827610258311223583112730.053000.003170.08984includedK562HNRNPU
SEVRK2ENSG00000028116.12chr2+583818885838193758373450583736095838648358387055-0.148000.000100.00649excludedK562SF3B1
A5SSVRK2ENSG00000028116.12chr2+5835894258359101583589425835906358362275583623340.151000.000080.00447longerK562PUS1
A5SSVRK2ENSG00000028116.12chr2+5831198858312134583119885831208558313473583135610.157000.000000.00011longerK562U2AF2

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for VRK2 is not avaliable on ENCORE database.