SPAST

General Information

Gene Name       : SPAST
Gene ID             : ENSG00000021574.12
Essential Gene : No

Functions

Localization

Domains (AlphaFold: SPAST)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878SPASTENSG00000021574.1212.3510.6311.49ENCSR000AEF
HepG2SPASTENSG00000021574.1210.7019.0314.87ENCSR985KAT
K562SPASTENSG00000021574.1215.4316.8116.12ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for SPAST is not avaliable on ENCORE database.



Proteins bound to RNA
  • SPAST RNA is bound by 6 proteins.  







eCLIP assay for SPAST is not avaliable on ENCORE database.





6 proteins are bound to SPAST RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr23237981432379860+3'-UTR4.532798.78414K562PUM2
chr23237968332379733+3'-UTR4.136093.06595HepG2BCLAF1
chr23238071032380808+3'-UTR3.8977014.39559K562PUM2
chr23237986432379922+3'-UTR4.7846325.48862K562PUM2
chr23228878732288894+5'-UTR4.6913021.60578HepG2DDX3X
chr23233977332339854+CDS4.816596.56044K562IGF2BP1
chr23228897532289032+CDS3.856529.09300HepG2DDX3X
chr23234118632341214+CDS,intron-Proximal4.261623.45943HepG2BCLAF1
chr23233974832339847+CDS4.937728.26986HepG2IGF2BP1
chr23231466832314773+CDS,intron-Proximal3.563215.78005K562KHSRP
chr23231576932315844+intron-Distal3.678024.72639K562KHSRP
chr23231592532316002+intron-Distal4.233064.96658K562KHSRP
chr23231584432315921+intron-Distal3.322234.08064K562KHSRP
chr23232902332329110+intron-Distal4.788735.44433K562EXOSC5
chr23235363932353761+intron-Distal,intron-Proximal3.439004.10408K562KHSRP
chr23231731032317464+intron-Distal3.267564.10408K562KHSRP
chr23235355032353627+intron-Proximal3.874363.49011K562KHSRP
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for SPAST is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for SPAST is not available on ENCORE database.

  • 80 RBPs can affect the levels of SPAST.  








The Knockdown/knockout RNA-Seq assay for SPAST is not available on ENCORE database.





80 RBPs can affect the gene expression of SPAST :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
SPASTENSG00000021574.7411.53370781.72140-0.9256010.953509.15020HepG2ADAR
SPASTENSG00000021574.72224.261701626.546700.451403.407302.82510HepG2AKAP1
SPASTENSG00000021574.7539.20800926.83000-0.781506.961005.43610HepG2BCCIP
SPASTENSG00000021574.7860.846501333.51670-0.631402.609901.66620HepG2CCAR1
SPASTENSG00000021574.7946.261201278.66500-0.434302.977902.17560HepG2CIRBP
SPASTENSG00000021574.7443.50410838.12670-0.9182019.4267018.01670HepG2CKAP4
SPASTENSG00000021574.7475.17800964.49970-1.021303.856602.94670HepG2CNOT7
SPASTENSG00000021574.7584.79850826.41520-0.498903.774502.98440HepG2CPSF6
SPASTENSG00000021574.7630.25870801.63490-0.347002.972701.91750HepG2YBX3
SPASTENSG00000021574.7762.196101090.35060-0.516607.047706.11130HepG2CELF1
SPASTENSG00000021574.7931.431601172.43980-0.332004.343903.44890HepG2DAZAP1
SPASTENSG00000021574.7584.44590802.77320-0.457904.418602.97640HepG2DDX1
SPASTENSG00000021574.7496.40810852.62970-0.780406.020704.20230HepG2DDX27
SPASTENSG00000021574.7695.01230911.27430-0.390802.220701.52140HepG2DDX55
SPASTENSG00000021574.7584.63440787.17350-0.429104.229803.37580HepG2DNAJC21
SPASTENSG00000021574.7332.09050780.18170-1.2322030.8414028.89080HepG2DNAJC2
SPASTENSG00000021574.7850.849301286.78400-0.596804.921604.14280HepG2EIF2S1
SPASTENSG00000021574.71006.696801422.17580-0.498503.645702.91420HepG2EIF4A3
SPASTENSG00000021574.7930.951801384.44310-0.572503.532202.75930HepG2EIF4B
SPASTENSG00000021574.71797.274301529.169300.233002.384701.81890HepG2ETF1
SPASTENSG00000021574.7512.99020827.80580-0.690402.549201.57730HepG2FTO
SPASTENSG00000021574.7912.829501434.52800-0.652205.871904.88890HepG2FXR1
SPASTENSG00000021574.7784.079801330.93900-0.763407.295706.23960HepG2G3BP1
SPASTENSG00000021574.7234.95050545.96100-1.2164013.9243012.05230HepG2GEMIN5
SPASTENSG00000021574.7507.51650936.84010-0.884309.138608.01880HepG2GPKOW
SPASTENSG00000021574.7680.89480883.95930-0.376502.640601.96210HepG2HNRNPC
SPASTENSG00000021574.71086.377701347.22020-0.310502.084401.47270HepG2HNRNPK
SPASTENSG00000021574.7567.284901068.01670-0.9128022.6500020.91200HepG2HNRNPL
SPASTENSG00000021574.7591.08810894.04060-0.597005.058204.23320HepG2HNRNPLL
SPASTENSG00000021574.7725.17280878.11610-0.276102.471601.89740HepG2HNRNPU
SPASTENSG00000021574.7892.067601352.94300-0.600905.014904.13070HepG2IGF2BP2
SPASTENSG00000021574.7625.53600896.96880-0.520007.977806.80100HepG2ILF2
SPASTENSG00000021574.7628.57030988.99650-0.653902.675701.45270HepG2KRR1
SPASTENSG00000021574.7924.272001407.15970-0.606402.755401.92700HepG2LARP4
SPASTENSG00000021574.7883.973301435.02710-0.699006.754005.74280HepG2MAGOH
SPASTENSG00000021574.71019.420401443.12180-0.501403.778403.05130HepG2MATR3
SPASTENSG00000021574.71054.164701477.16670-0.486703.813703.07590HepG2NCBP2
SPASTENSG00000021574.7902.487901162.58650-0.365403.686202.80420HepG2NOL12
SPASTENSG00000021574.7960.519201315.74880-0.454003.169802.39870HepG2PABPC4
SPASTENSG00000021574.7684.37340869.20150-0.344903.310502.39180HepG2PARN
SPASTENSG00000021574.7543.81260783.21170-0.526305.931004.88300HepG2PPIL4
SPASTENSG00000021574.71009.083101272.50770-0.334603.648303.03860HepG2PTBP1
SPASTENSG00000021574.7876.803301109.77800-0.339902.677802.08940HepG2PUF60
SPASTENSG00000021574.7957.548701177.21220-0.298002.489901.85350HepG2PUM2
SPASTENSG00000021574.7668.30810853.90270-0.353603.737303.04390HepG2PUS1
SPASTENSG00000021574.71421.53980843.928600.752204.681703.77800HepG2RAVER1
SPASTENSG00000021574.71577.059101278.109400.303103.187002.64110HepG2RBM22
SPASTENSG00000021574.7449.16750596.62720-0.409602.711902.10150HepG2RPS19
SPASTENSG00000021574.7427.41780782.00920-0.8715015.9928014.63620HepG2SAFB2
SPASTENSG00000021574.7907.336601064.07380-0.229902.183501.54790HepG2SLBP
SPASTENSG00000021574.7651.73910911.96830-0.484707.146806.18850HepG2SMN1
SPASTENSG00000021574.7896.070401246.15800-0.475807.890706.92940HepG2SUCLG1
SPASTENSG00000021574.7627.18910907.14770-0.532403.766802.99500HepG2SUPV3L1
SPASTENSG00000021574.7890.699301142.08690-0.358703.145002.25870HepG2TIA1
SPASTENSG00000021574.7415.74130853.30470-1.0374017.7790016.71350HepG2TIAL1
SPASTENSG00000021574.7387.07330860.87800-1.1532026.6096025.08470HepG2TRIM56
SPASTENSG00000021574.71061.38990797.788400.411803.055102.39640HepG2U2AF1
SPASTENSG00000021574.7453.09750830.63830-0.874406.344504.78170HepG2UPF2
SPASTENSG00000021574.71210.99760829.669700.545503.279801.89510HepG2XRCC5
SPASTENSG00000021574.7370.88640892.98770-1.2677018.0313016.22930HepG2XRN2
SPASTENSG00000021574.7745.13280976.38310-0.389905.175404.48620HepG2ZNF622
SPASTENSG00000021574.7766.09370565.283500.438403.258901.96370K562AARS
SPASTENSG00000021574.7776.80270969.28320-0.319403.114902.51830K562AGGF1
SPASTENSG00000021574.7958.913701327.78070-0.469504.294903.59440K562AQR
SPASTENSG00000021574.7909.371601266.85730-0.478306.071504.39920K562CPEB4
SPASTENSG00000021574.7502.81450649.01350-0.368203.221201.77850K562DDX27
SPASTENSG00000021574.71804.927901310.992800.461208.035807.00240K562DDX47
SPASTENSG00000021574.7492.25970673.11330-0.451402.363701.31980K562EIF4B
SPASTENSG00000021574.71825.557601512.651000.271203.344102.31440K562EIF4G2
SPASTENSG00000021574.71054.10930799.980800.397902.169701.55430K562G3BP2
SPASTENSG00000021574.7313.78860646.40130-1.042607.046904.77910K562GEMIN5
SPASTENSG00000021574.7775.645801282.21060-0.725203.510102.66130K562GRSF1
SPASTENSG00000021574.7904.214201184.75180-0.389803.495002.28970K562HNRNPL
SPASTENSG00000021574.7396.84210576.77200-0.539402.836701.88790K562KRR1
SPASTENSG00000021574.7654.57960830.58290-0.343603.183002.31590K562MTPAP
SPASTENSG00000021574.7410.33000609.00290-0.569704.006702.14610K562NUSAP1
SPASTENSG00000021574.7821.630401072.77890-0.384803.031902.16790K562PPIG
SPASTENSG00000021574.7333.77420554.57360-0.732506.409804.94190K562PSIP1
SPASTENSG00000021574.7579.91320812.36230-0.486303.972301.85830K562RECQL
SPASTENSG00000021574.7832.86800639.230200.381702.376501.62130K562RPS19
SPASTENSG00000021574.7462.93770764.49500-0.723702.497301.37820K562SF1
SPASTENSG00000021574.7677.42630831.90880-0.296402.160801.40550K562SF3B4
SPASTENSG00000021574.7582.97930932.10860-0.677102.735401.44720K562SFPQ
SPASTENSG00000021574.7815.52460578.941100.494204.789003.70140K562SYNCRIP
SPASTENSG00000021574.7692.70350958.08830-0.467902.862302.02750K562TIA1
SPASTENSG00000021574.7392.45470533.40650-0.442702.434601.55980K562TIAL1
SPASTENSG00000021574.7416.30750566.68100-0.444902.740101.80030K562TRIM56
SPASTENSG00000021574.7627.80150800.91720-0.351302.739801.93900K562U2AF2
SPASTENSG00000021574.7642.51440978.50490-0.606909.738908.49280K562UPF1
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for SPAST is not available on ENCORE database.





7 RBPs can affect the splicing of SPAST :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SESPASTENSG00000021574.7chr2+3232386432323960323145903231467432339706323398940.138000.001000.07539includedHepG2QKI
SESPASTENSG00000021574.7chr2+3232386432323960323145903231467432339706323398940.088000.000300.01834includedHepG2SFPQ
SESPASTENSG00000021574.7chr2+323238643232396032314590323146743233970632339894-0.217000.001450.05710excludedHepG2HNRNPU
A3SSSPASTENSG00000021574.7chr2+3236161332361707323616313236170732353396323535480.241000.001810.01179longerK562AQR
A3SSSPASTENSG00000021574.7chr2+3236192232362037323619453236203732361631323617070.096000.008670.04678longerK562AQR
A3SSSPASTENSG00000021574.7chr2+3236216232362257323621773236225732361945323620370.083000.001330.00895longerK562AQR
MXESPASTENSG00000021574.7chr2+32323864323239603233970632339894323145903231467432340770323409040.206000.000540.039131includedHepG2IGF2BP3
MXESPASTENSG00000021574.7chr2+32352016323520913235347632353548323411873234128132361631323617070.222000.000630.013351includedK562DROSHA
MXESPASTENSG00000021574.7chr2+32352016323520913235347632353548323411873234128132361631323617070.251000.000250.009341includedK562HNRNPUL1

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for SPAST is not avaliable on ENCORE database.