NEDD8

General Information

Gene Name       : NEDD8
Gene ID             : ENSG00000129559.12
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: NEDD8)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878NEDD8ENSG00000129559.12194.13202.63198.38ENCSR000AEF
HepG2NEDD8ENSG00000129559.12722.61620.97671.79ENCSR985KAT
K562NEDD8ENSG00000129559.12168.66151.41160.03ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for NEDD8 is not avaliable on ENCORE database.



Proteins bound to RNA
  • NEDD8 RNA is bound by 28 proteins.  







eCLIP assay for NEDD8 is not avaliable on ENCORE database.





28 proteins are bound to NEDD8 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr142468622124686283-3'-UTR,intron-Distal,intron-Proximal5.09032400.00000HepG2LARP4
chr142468622024686256-3'-UTR,intron-Distal,intron-Proximal3.9283238.04414HepG2DDX55
chr142468613524686225-3'-UTR,intron-Distal,intron-Proximal3.3455116.97396HepG2GRWD1
chr142468617724686200-3'-UTR,intron-Distal,intron-Proximal5.2036643.07582HepG2LARP4
chr142468609624686172-3'-UTR,intron-Distal,intron-Proximal3.949273.78929K562NOLC1
chr142468608624686140-3'-UTR,intron-Distal,intron-Proximal5.0639533.61192HepG2LARP4
chr142468618124686216-3'-UTR,intron-Distal,intron-Proximal3.933326.88718HepG2AKAP1
chr142468732924687425-3'-UTR,CDS,intron-Distal,intron-Proximal3.0247920.54702HepG2AQR
chr142468614824686232-3'-UTR,intron-Distal,intron-Proximal4.303997.11997HepG2SUB1
chr142468640524686441-3'-UTR,CDS,intron-Distal,intron-Proximal3.791076.67313HepG2BCLAF1
chr142468615124686328-3'-UTR,intron-Distal,intron-Proximal3.031863.38426HepG2UPF1
chr142468630024686353-3'-UTR,CDS,intron-Distal,intron-Proximal6.0778159.55867HepG2LARP4
chr142468609424686155-3'-UTR,intron-Distal,intron-Proximal3.5729415.19016HepG2DDX55
chr142468601724686069-3'-UTR,intron-Distal,intron-Proximal,polyA_site3.698813.14687K562CSTF2T
chr142468609724686150-3'-UTR,intron-Distal,intron-Proximal4.204654.31023HepG2LIN28B
chr142468615024686216-3'-UTR,intron-Distal,intron-Proximal5.1244910.68247K562PABPC4
chr142468632224686347-3'-UTR,CDS,intron-Distal,intron-Proximal4.399668.80691HepG2GRWD1
chr142468639524686453-3'-UTR,CDS,intron-Distal,intron-Proximal3.0181811.63693HepG2U2AF2
chr142468615024686177-3'-UTR,intron-Distal,intron-Proximal4.6136125.26190HepG2LARP4
chr142468630324686316-3'-UTR,intron-Distal,intron-Proximal3.332575.53331HepG2GRWD1
chr142468634724686376-3'-UTR,CDS,intron-Distal,intron-Proximal3.528016.39282HepG2GRWD1
chr142468617724686223-3'-UTR,intron-Distal,intron-Proximal4.6584118.10022HepG2LIN28B
chr142468628324686300-3'-UTR,intron-Distal,intron-Proximal4.9998355.86410HepG2LARP4
chr142468732624687422-3'-UTR,CDS,intron-Distal,intron-Proximal3.2744826.63658HepG2BCLAF1
chr142468626324686303-3'-UTR,intron-Distal,intron-Proximal3.2145418.62284HepG2GRWD1
chr142468621624686287-3'-UTR,intron-Distal,intron-Proximal4.4571018.24884K562PABPC4
chr142468628724686319-3'-UTR,intron-Distal,intron-Proximal4.815805.42839K562PABPC4
chr142468730424687351-3'-UTR,CDS,intron-Distal,intron-Proximal5.465817.02967HepG2PRPF8
chr142468618124686224-3'-UTR,intron-Distal,intron-Proximal3.725823.43526K562GRWD1
chr142468625624686325-3'-UTR,intron-Distal,intron-Proximal4.3743851.70489HepG2DDX55
chr142468623024686326-3'-UTR,intron-Distal,intron-Proximal3.488595.18217K562PUM1
chr142468608624686150-3'-UTR,intron-Distal,intron-Proximal4.782249.84602K562PABPC4
chr142468608524686148-3'-UTR,intron-Distal,intron-Proximal3.810295.31144HepG2SUB1
chr142468621624686313-3'-UTR,intron-Distal,intron-Proximal3.261349.91988HepG2AKAP1
chr142468612924686181-3'-UTR,intron-Distal,intron-Proximal3.054326.27467HepG2AKAP1
chr142468733024687423-3'-UTR,CDS,intron-Distal,intron-Proximal3.4530514.44062K562UCHL5
chr142468616824686222-3'-UTR,intron-Distal,intron-Proximal4.777415.00488K562LIN28B
chr142468596424686073-3'-UTR,intron-Distal,intron-Proximal,polyA_site3.861535.18472HepG2CSTF2
chr142470148124701506-5'-UTR,intron-Distal,intron-Proximal3.4575816.37623HepG2GRWD1
chr142470145424701481-5'-UTR,CDS,intron-Distal4.5011922.38767HepG2GRWD1
chr142470148924701563-5'-UTR,intron-Distal,intron-Proximal3.7266010.26816K562DDX3X
chr142470145324701557-5'-UTR,CDS,intron-Distal,intron-Proximal3.0678210.76810K562ZNF622
chr142470145524701487-5'-UTR,CDS,intron-Distal4.208726.99054K562DDX55
chr142468758624687647-CDS,intron-Distal,intron-Proximal3.028684.50012HepG2FTO
chr142468740324687470-CDS,intron-Distal,intron-Proximal4.8412614.08248HepG2SF3B4
chr142468758924687621-CDS,intron-Distal,intron-Proximal3.6917221.08645HepG2GRWD1
chr142468758824687619-CDS,intron-Distal,intron-Proximal3.070128.19895HepG2ZNF800
chr142468734124687385-CDS,intron-Distal3.9824016.99896HepG2LARP4
chr142468758924687616-CDS,intron-Distal,intron-Proximal3.5048719.92431HepG2LARP4
chr142468737824687452-CDS,intron-Distal,intron-Proximal3.769266.86197HepG2PRPF8
chr142470144624701467-CDS,intron-Distal3.3193312.28725HepG2PRPF8
chr142468758824687628-CDS,intron-Distal,intron-Proximal3.6923210.76678K562UCHL5
chr142468733724687360-CDS,intron-Distal,intron-Proximal3.5249410.09142HepG2GRWD1
chr142468761624687636-CDS,intron-Distal3.069757.54974HepG2LARP4
chr142468735424687417-CDS,intron-Distal3.708435.13092K562APOBEC3C
chr142468738924687399-CDS,intron-Distal3.1935812.77913HepG2GRWD1
chr142468741824687421-CDS,intron-Distal3.0003810.85786HepG2GRWD1
chr142468762124687638-CDS,intron-Distal,intron-Proximal4.1621812.94750HepG2GRWD1
chr142468736724687421-CDS,intron-Distal3.322817.02736K562PABPC4
chr142468738524687422-CDS,intron-Distal,intron-Proximal4.0893527.04926HepG2LARP4
chr142468733824687423-CDS,intron-Distal,intron-Proximal3.1414815.84185K562ZNF800
chr142468761124687639-CDS,intron-Distal,intron-Proximal3.515285.60676K562DDX55
chr142468756024687599-CDS,intron-Distal,intron-Proximal4.1837111.50355HepG2PRPF8
chr142468739924687409-CDS,intron-Distal3.3314213.83511HepG2GRWD1
chr142468740924687418-CDS,intron-Distal3.2296013.76316HepG2GRWD1
chr142468736024687389-CDS,intron-Distal3.8888512.72593HepG2GRWD1
chr142470141524701452-intron-Distal3.917547.80656HepG2GRWD1
chr142470141124701446-intron-Distal4.2210613.03969HepG2PRPF8
chr142469255224692609-intron-Distal3.968937.21362HepG2ILF3
chr142470099824701084-intron-Distal,intron-Proximal3.374656.31016HepG2HNRNPK
chr142469786724697930-intron-Distal3.087968.47905HepG2HNRNPC
chr142468679224686842-intron-Distal,intron-Proximal3.999146.02363HepG2U2AF2
chr142469622024696283-intron-Distal3.827016.09419HepG2KHSRP
chr142468742524687469-intron-Distal,intron-Proximal3.867475.90528HepG2AQR
chr142469617824696289-intron-Distal3.355034.35650K562KHSRP
chr142469285124692930-intron-Distal3.442998.12901HepG2ILF3
chr142469809124698195-intron-Distal3.207145.19856HepG2PTBP1
chr142469254324692612-intron-Distal3.099964.63037HepG2HNRNPC
chr142470117324701236-intron-Distal,intron-Proximal3.299233.85440HepG2HNRNPC
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for NEDD8 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for NEDD8 is not available on ENCORE database.

  • 94 RBPs can affect the levels of NEDD8.  








The Knockdown/knockout RNA-Seq assay for NEDD8 is not available on ENCORE database.





94 RBPs can affect the gene expression of NEDD8 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
NEDD8ENSG00000129559.84261.226703575.531800.253004.478303.74130HepG2ACO1
NEDD8ENSG00000129559.86323.818205105.097300.308802.546601.80160HepG2CIRBP
NEDD8ENSG00000129559.81647.485802673.10330-0.698204.260103.06240HepG2DDX59
NEDD8ENSG00000129559.82483.363403580.46080-0.527804.304002.91070HepG2AGO1
NEDD8ENSG00000129559.84095.111205137.16510-0.327102.555501.98560HepG2EIF2S1
NEDD8ENSG00000129559.82993.406703671.58590-0.294603.115801.97330HepG2EIF3G
NEDD8ENSG00000129559.85736.216006649.30550-0.213102.880902.02990HepG2EIF4G1
NEDD8ENSG00000129559.85327.725606566.18970-0.301505.790404.97350HepG2ETF1
NEDD8ENSG00000129559.84343.518903493.751700.314003.338402.42200HepG2EWSR1
NEDD8ENSG00000129559.82744.612303639.62900-0.407204.907203.87630HepG2FUBP3
NEDD8ENSG00000129559.84291.287605641.37940-0.394603.738002.69250HepG2G3BP2
NEDD8ENSG00000129559.81585.238602282.05080-0.525605.351904.10230HepG2GEMIN5
NEDD8ENSG00000129559.82704.961503413.48510-0.335605.999404.62480HepG2HDGF
NEDD8ENSG00000129559.83797.965704359.05200-0.198802.713102.00270HepG2HNRNPF
NEDD8ENSG00000129559.84265.083205381.03710-0.335303.186502.43880HepG2HNRNPK
NEDD8ENSG00000129559.82808.858303725.08600-0.407309.007007.96090HepG2HNRNPU
NEDD8ENSG00000129559.83970.525605401.10500-0.443904.317603.49040HepG2IGF2BP2
NEDD8ENSG00000129559.83187.339205432.73440-0.769308.320206.49800HepG2KHSRP
NEDD8ENSG00000129559.84728.125005730.30700-0.277301.938201.38390HepG2MAGOH
NEDD8ENSG00000129559.84572.802605762.31120-0.333602.377001.78950HepG2MATR3
NEDD8ENSG00000129559.84773.933505897.99090-0.305002.188701.62330HepG2NCBP2
NEDD8ENSG00000129559.82934.986505252.29270-0.8396013.0951011.55030HepG2PABPC4
NEDD8ENSG00000129559.83222.401405354.57460-0.7326028.8316027.22340HepG2PCBP1
NEDD8ENSG00000129559.82819.863004118.16070-0.546403.734102.53310HepG2PCBP2
NEDD8ENSG00000129559.82431.228603322.48820-0.450608.263607.03910HepG2PPIL4
NEDD8ENSG00000129559.83804.247105448.49150-0.5182014.5230013.46130HepG2PTBP1
NEDD8ENSG00000129559.84550.356006379.35090-0.487406.627305.75800HepG2PUF60
NEDD8ENSG00000129559.85708.887906772.22110-0.246404.150703.45610HepG2PUM1
NEDD8ENSG00000129559.85163.195306767.11370-0.390305.848604.88660HepG2PUM2
NEDD8ENSG00000129559.83818.038505900.82600-0.6281015.8490014.53200HepG2QKI
NEDD8ENSG00000129559.86563.778905488.139700.258103.891503.30470HepG2RBM22
NEDD8ENSG00000129559.83708.764105355.38820-0.530108.930107.77130HepG2RBM25
NEDD8ENSG00000129559.81417.697003156.70740-1.154904.293902.22470HepG2RBM39
NEDD8ENSG00000129559.84249.451706063.63820-0.5129014.9226013.85380HepG2NELFE
NEDD8ENSG00000129559.83650.602205647.47250-0.6295022.3410020.88140HepG2RECQL
NEDD8ENSG00000129559.82789.304703904.26260-0.485102.949601.97630HepG2RPS10
NEDD8ENSG00000129559.81980.871702494.06320-0.332403.406702.73280HepG2RPS19
NEDD8ENSG00000129559.82234.672302900.78030-0.376402.801102.01030HepG2RRP9
NEDD8ENSG00000129559.84094.009305672.56200-0.4705013.0572011.92160HepG2SF3B4
NEDD8ENSG00000129559.84731.070906117.33380-0.370706.844405.82070HepG2SLBP
NEDD8ENSG00000129559.87397.059506198.687500.254905.429804.79230HepG2SRFBP1
NEDD8ENSG00000129559.85161.425205920.93520-0.198103.170302.67330HepG2SRSF1
NEDD8ENSG00000129559.82045.560402712.11240-0.406902.865501.84510HepG2SRSF3
NEDD8ENSG00000129559.84856.478606298.98960-0.375206.148005.26720HepG2SRSF5
NEDD8ENSG00000129559.83775.430304282.69270-0.181902.478601.81600HepG2SRSF7
NEDD8ENSG00000129559.82563.675604817.00350-0.9099045.0458043.35730HepG2SRSF9
NEDD8ENSG00000129559.84731.105205381.99060-0.186002.571602.07190HepG2SSB
NEDD8ENSG00000129559.82685.573903713.54610-0.467602.792701.58420HepG2SUB1
NEDD8ENSG00000129559.86290.542107163.42120-0.187502.745202.12550HepG2SUCLG1
NEDD8ENSG00000129559.83013.687005321.99110-0.8204028.0435026.49960HepG2TAF15
NEDD8ENSG00000129559.83448.830904890.15970-0.503808.413706.96180HepG2TIA1
NEDD8ENSG00000129559.83129.031303619.81270-0.210202.059201.61460HepG2TIAL1
NEDD8ENSG00000129559.82754.282903990.75960-0.535003.721902.02620HepG2TRA2A
NEDD8ENSG00000129559.82799.715803651.96120-0.383407.931107.05410HepG2TRIM56
NEDD8ENSG00000129559.84947.487406597.57480-0.415203.543502.59120HepG2UBE2L3
NEDD8ENSG00000129559.82535.422303908.37260-0.624304.898903.20570HepG2XRCC5
NEDD8ENSG00000129559.82920.394602480.062600.235703.800803.03550HepG2ZC3H8
NEDD8ENSG00000129559.83974.186003330.172000.255005.293004.59890HepG2ZNF622
NEDD8ENSG00000129559.82637.938803970.91640-0.590104.850503.08520HepG2ZRANB2
NEDD8ENSG00000129559.82117.806601433.721100.5627012.8315011.70630K562AGGF1
NEDD8ENSG00000129559.82223.589701491.870900.575707.978406.81410K562AKAP8L
NEDD8ENSG00000129559.81123.587801501.18390-0.418006.245404.77800K562BCLAF1
NEDD8ENSG00000129559.8508.27600709.40360-0.481003.436402.23560K562CCAR1
NEDD8ENSG00000129559.81309.430901895.58140-0.533702.827301.74990K562CNOT7
NEDD8ENSG00000129559.8937.559401138.87160-0.280602.449701.46450K562CSTF2
NEDD8ENSG00000129559.8585.44510794.14310-0.439903.123401.70950K562DHX30
NEDD8ENSG00000129559.8582.84180762.86240-0.388302.668901.35110K562DNAJC21
NEDD8ENSG00000129559.8439.74540721.59960-0.714503.909502.68980K562EIF3A
NEDD8ENSG00000129559.8749.637401077.95650-0.524002.753801.49050K562EXOSC5
NEDD8ENSG00000129559.81443.063701141.953300.337503.839603.14390K562FXR1
NEDD8ENSG00000129559.81047.738801359.86880-0.376202.087501.48480K562G3BP2
NEDD8ENSG00000129559.8925.935901367.69300-0.562804.972903.04020K562GEMIN5
NEDD8ENSG00000129559.81018.721301311.96430-0.365003.846102.50820K562GLRX3
NEDD8ENSG00000129559.8783.265401123.74390-0.520702.288101.56590K562GPKOW
NEDD8ENSG00000129559.8761.163901241.22040-0.705509.544808.48970K562HNRNPC
NEDD8ENSG00000129559.81703.964801090.581700.643706.556905.03040K562HNRNPM
NEDD8ENSG00000129559.81543.585701973.12120-0.354204.301703.17920K562HNRNPU
NEDD8ENSG00000129559.8515.46470716.31680-0.474703.320201.68720K562KHDRBS1
NEDD8ENSG00000129559.81902.932601583.180900.265302.382701.62550K562KIF1C
NEDD8ENSG00000129559.81101.458301379.36310-0.324603.990603.03410K562MTPAP
NEDD8ENSG00000129559.81211.039501532.57550-0.339705.574404.57020K562NSUN2
NEDD8ENSG00000129559.81133.543401821.09910-0.684004.546302.92840K562PABPC1
NEDD8ENSG00000129559.81930.079001505.172600.358602.991602.13400K562PPIG
NEDD8ENSG00000129559.8809.190501112.86600-0.459703.781302.70040K562PSIP1
NEDD8ENSG00000129559.82780.264903201.93410-0.203702.456301.55040K562PUM2
NEDD8ENSG00000129559.82272.658501479.390000.619308.307807.41490K562PUS1
NEDD8ENSG00000129559.81997.355601441.555800.470407.424906.48490K562RBM15
NEDD8ENSG00000129559.81053.487601699.77930-0.690202.901601.32100K562RBM39
NEDD8ENSG00000129559.8763.323101015.25850-0.411503.610202.48060K562RCC2
NEDD8ENSG00000129559.81182.862901726.65810-0.545703.042101.43870K562SBDS
NEDD8ENSG00000129559.81260.325501512.29180-0.262902.738701.92800K562SF3A3
NEDD8ENSG00000129559.8721.935901068.46840-0.565602.312301.43150K562SF3B1
NEDD8ENSG00000129559.8968.735101325.46320-0.452303.834201.88260K562SRP68
NEDD8ENSG00000129559.8497.07620672.32100-0.435702.970501.87050K562SRSF4
NEDD8ENSG00000129559.8928.990001197.24210-0.366002.924901.35940K562SRSF9
NEDD8ENSG00000129559.8852.607801285.55690-0.592405.099503.68260K562SUPV3L1
NEDD8ENSG00000129559.8741.916401070.40160-0.528804.313003.12570K562TIAL1
NEDD8ENSG00000129559.8836.031401137.06560-0.443703.862802.70940K562TRIM56
NEDD8ENSG00000129559.8711.78340996.84950-0.485903.335001.37330K562TRNAU1AP
NEDD8ENSG00000129559.8778.656101360.49210-0.8051010.085308.09130K562UCHL5
NEDD8ENSG00000129559.81137.556201390.47900-0.289602.358901.54960K562WDR3
NEDD8ENSG00000129559.8966.611601385.18530-0.519104.642302.92540K562XRN2
NEDD8ENSG00000129559.82012.565202637.62980-0.390204.095603.01240K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for NEDD8 is not available on ENCORE database.





1 RBPs can affect the splicing of NEDD8 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
A3SSNEDD8ENSG00000129559.8chr14-2470085724701073247008572470094324701455247015610.282000.000970.07588longerHepG2HNRNPK

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for NEDD8 is not avaliable on ENCORE database.