SRP68

General Information

Gene Name : SRP68
Gene ID : ENSG00000167881.14
Essential Gene : Yes

Functions

Other

Localization(RBPImage: SRP68)

Cytoplasm
Compartment/Organelle
Golgi
Cytosolic

Domains (AlphaFold: SRP68)

No checked domain (RRM, ZNF, KH, Helicase, Nuclease, dRBM or PUM_HD)

Antibody Validation

Bethyl Labs: A303-955A

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	SRP68	ENSG00000167881.14	47.29	50.00	48.64	ENCSR000AEF
HepG2	SRP68	ENSG00000167881.14	90.56	109.96	100.26	ENCSR985KAT
K562	SRP68	ENSG00000167881.14	61.93	62.31	62.12	ENCSR000AEO

Assays

2 Released experiments are available on ENCORE database.

Assay Type	Exp_Name	ENCODE ID	Target label	Biosample	Status	Linked Antibody	Controls	Method	Note
knockdown followed by RNA-seq	SRP68-BGKLV19-K562	ENCSR312SRB	SRP68	K562	Released		ENCSR661HEL	shRNA	KD% = 68.9,47.2
knockdown followed by RNA-seq	SRP68-BGHLV17-HepG2	ENCSR167JPY	SRP68	HepG2	Released		ENCSR856ZRV	shRNA	KD% = 79.2,78.1

eCLIP

No eCLIP experiment available

Antibody Validation

GeneName	Antibody_DCC_ID	Product_ID	Lot_ID	Phosphate	HepG2 Primary Validation	K562 Primary Validation	HepG2 Secondary Validation	K562 Secondary Validation
SRP68	ENCAB434DUK	A303-955A	1		Released, ENCODE3	Released, ENCODE3	BGHLV17-29, Released, ENCODE3	BGKLV19-51, Released, ENCODE3

KD RNA-Seq

GeneName	Cell_Line	Method	Exp_ID	Control_ID	Sample_reps	Control_reps	KD%	Status	Project
SRP68	K562	shRNA	ENCSR312SRB	ENCSR661HEL	SRP68_BGKLV19_51B,SRP68_BGKLV19_52B	NT_BGKLV19_1B,NT_BGKLV19_2B	68.9,47.2	Released	ENCODE3
SRP68	HepG2	shRNA			BGHLV16-53,BGHLV16-54	BGHLV16-1,BGHLV16-2		NotSatisfied	ENCODE3
SRP68	HepG2	shRNA	ENCSR167JPY	ENCSR856ZRV	SRP68_BGHLV17_29,SRP68_BGHLV17_30	NT_BGHLV17_63,NT_BGHLV17_64	79.2,78.1	Released	ENCODE3
SRP68	293T	shRNA			BG293LV01-65,BG293LV01-66	BG293LV01-1,BG293LV01-2		NotSatisfied	ENCORE2
SRP68	293T	shRNA			SRP68-BG293LV04-77,SRP68-BG293LV04-78	NT-BG293LV04-1,NT-BG293LV04-2	,	Submitting	ENCORE2
SRP68	293T	shRNA			BG293LV04-79,BG293LV04-80	BG293LV04-1,BG293LV04-2		NotSatisfied	ENCORE2
SRP68	293T	shRNA			SRP68-BG293LV06-53,SRP68-BG293LV06-54	NT-BG293LV06-1,NT-BG293LV06-2	,	Sequenced	ENCORE2

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

SRP68: Click to RBP Image Database

Cytoplasm

Compartment/Organelle

Golgi

Cytosolic

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela
SRP68	Product_ID: A303-955A Lot_ID: 1 Source: Bethyl Labs Target Name: SRP68-human

Summary
Proteins Bound to RBP RNA

RNA Targets

eCLIP assay for SRP68 is not avaliable on ENCORE database.

Proteins bound to RNA

SRP68 RNA is bound by 21 proteins.

eCLIP assay for SRP68 is not avaliable on ENCORE database.

21 proteins are bound to SRP68 RNA:

Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr17	74060190	74060245	-	3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal	3.92792	5.98815	HepG2	G3BP1
chr17	74036938	74037003	-	3'-UTR,CDS,intron-Distal,intron-Proximal	3.60388	9.78963	HepG2	PRPF8
chr17	74046516	74046577	-	3'-UTR,5'-UTR,CDS,intron-Distal	4.91754	8.55937	HepG2	GRWD1
chr17	74060166	74060253	-	3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal	3.11058	6.90893	HepG2	GRWD1
chr17	74039969	74040025	-	3'-UTR,CDS,intron-Distal	4.15634	3.39686	HepG2	G3BP1
chr17	74036942	74037016	-	3'-UTR,CDS,intron-Distal,intron-Proximal	4.32472	7.26476	HepG2	AQR
chr17	74046511	74046601	-	3'-UTR,5'-UTR,CDS,intron-Distal	3.71279	3.25205	K562	GRWD1
chr17	74035836	74035951	-	3'-UTR,CDS,intron-Distal	5.13008	8.98006	K562	RBM15
chr17	74046508	74046604	-	3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal	4.43215	8.81535	HepG2	G3BP1
chr17	74042069	74042127	-	3'-UTR,CDS,intron-Distal,intron-Proximal	4.99873	11.76457	HepG2	PRPF8
chr17	74035462	74035551	-	3'-UTR,intron-Distal,intron-Proximal	4.11726	8.28779	HepG2	SUB1
chr17	74039848	74039916	-	3'-UTR,CDS,intron-Distal,intron-Proximal	3.48523	3.64266	HepG2	PPIG
chr17	74039909	74039970	-	3'-UTR,CDS,intron-Distal,intron-Proximal	3.38913	4.30677	K562	YBX3
chr17	74035278	74035352	-	3'-UTR,intron-Distal	3.15006	7.37965	K562	YBX3
chr17	74035585	74035649	-	3'-UTR,intron-Distal,intron-Proximal	3.14280	4.17855	K562	YBX3
chr17	74063340	74063428	-	3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal	3.56924	6.28932	HepG2	AQR
chr17	74060223	74060288	-	3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal	3.46454	5.81258	K562	AQR
chr17	74063384	74063412	-	3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal	3.34455	3.95937	K562	UCHL5
chr17	74037016	74037064	-	3'-UTR,CDS,intron-Distal,intron-Proximal	3.42521	3.09957	HepG2	AQR
chr17	74035845	74035889	-	3'-UTR,CDS,intron-Distal	3.12404	3.40321	HepG2	GRWD1
chr17	74035621	74035695	-	3'-UTR,intron-Distal,intron-Proximal	4.36437	4.46921	K562	RBM15
chr17	74060191	74060270	-	3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal	3.86172	5.56912	HepG2	AQR
chr17	74035671	74035733	-	3'-UTR,intron-Distal	4.30131	6.57313	K562	PABPC4
chr17	74060053	74060155	-	3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal	3.74504	3.05347	HepG2	UCHL5
chr17	74046577	74046608	-	3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal	3.10718	3.79741	HepG2	GRWD1
chr17	74060049	74060153	-	3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal	3.20579	7.28455	K562	ZNF622
chr17	74035754	74035806	-	3'-UTR,CDS,intron-Distal	4.13543	3.35081	HepG2	G3BP1
chr17	74039853	74039936	-	3'-UTR,CDS,intron-Distal,intron-Proximal	3.65854	8.16221	HepG2	PRPF8
chr17	74042063	74042128	-	3'-UTR,CDS,intron-Distal,intron-Proximal	4.69276	5.33214	K562	PRPF8
chr17	74039866	74039921	-	3'-UTR,CDS,intron-Distal,intron-Proximal	5.04875	5.68078	HepG2	AQR
chr17	74035723	74035808	-	3'-UTR,CDS,intron-Distal	3.82747	6.04895	HepG2	LARP4
chr17	74041321	74041404	-	3'-UTR,CDS,intron-Distal,intron-Proximal	6.05630	14.22378	HepG2	PRPF8
chr17	74053483	74053536	-	5'-UTR,CDS,intron-Distal,intron-Proximal	4.37815	4.25741	HepG2	G3BP1
chr17	74057173	74057223	-	5'-UTR,CDS,intron-Distal,intron-Proximal	4.91405	4.94356	HepG2	PRPF8
chr17	74068383	74068518	-	5'-UTR,CDS,intron-Distal	3.41330	7.58911	K562	UCHL5
chr17	74066457	74066478	-	5'-UTR,CDS,intron-Distal,intron-Proximal	3.46061	4.24070	HepG2	GRWD1
chr17	74053511	74053595	-	5'-UTR,CDS,intron-Distal	4.40636	8.23108	K562	UCHL5
chr17	74068387	74068510	-	5'-UTR,CDS,intron-Distal	4.07547	13.16675	HepG2	GRWD1
chr17	74053536	74053625	-	5'-UTR,CDS,intron-Distal,intron-Proximal	5.35544	10.59349	HepG2	G3BP1
chr17	74066458	74066517	-	5'-UTR,CDS,intron-Distal,intron-Proximal	3.78109	5.08388	K562	UCHL5
chr17	74056387	74056417	-	5'-UTR,CDS,intron-Distal,intron-Proximal	4.08034	3.68241	HepG2	G3BP1
chr17	74053481	74053527	-	5'-UTR,CDS,intron-Distal,intron-Proximal	3.07384	4.07132	HepG2	GRWD1
chr17	74068412	74068474	-	5'-UTR,CDS,intron-Distal	3.02841	3.84932	K562	ZNF800
chr17	74057572	74057656	-	5'-UTR,CDS,intron-Distal,intron-Proximal	3.04966	5.13250	K562	YBX3
chr17	74057189	74057300	-	5'-UTR,CDS,intron-Distal,intron-Proximal	3.31280	5.81406	HepG2	GRWD1
chr17	74060041	74060096	-	5'-UTR,CDS,intron-Distal,intron-Proximal	3.93496	4.16174	HepG2	PRPF8
chr17	74053443	74053527	-	5'-UTR,CDS,intron-Distal,intron-Proximal	4.35268	22.44460	HepG2	PRPF8
chr17	74066423	74066493	-	5'-UTR,CDS,intron-Distal,intron-Proximal	4.47619	5.05356	HepG2	PRPF8
chr17	74056353	74056419	-	5'-UTR,CDS,intron-Distal,intron-Proximal	3.50242	4.83899	HepG2	PRPF8
chr17	74057197	74057299	-	5'-UTR,CDS,intron-Distal,intron-Proximal	3.47065	9.63625	K562	YBX3
chr17	74053432	74053501	-	5'-UTR,CDS,intron-Distal,intron-Proximal	4.23259	7.05055	K562	PRPF8
chr17	74057187	74057240	-	5'-UTR,CDS,intron-Distal,intron-Proximal	3.08034	3.85381	HepG2	BCLAF1
chr17	74068412	74068510	-	5'-UTR,CDS,intron-Distal	3.81151	6.24124	HepG2	G3BP1
chr17	74057544	74057663	-	5'-UTR,CDS,intron-Distal,intron-Proximal	3.64841	7.17852	HepG2	AQR
chr17	74053530	74053619	-	5'-UTR,CDS,intron-Distal	3.87279	5.74979	HepG2	GRWD1
chr17	74036938	74036984	-	intron-Distal,intron-Proximal	5.43587	5.69951	K562	AQR
chr17	74037064	74037125	-	intron-Distal,intron-Proximal	4.90647	4.28193	HepG2	AQR
chr17	74047851	74047949	-	intron-Distal	4.66961	5.02084	HepG2	HNRNPM
chr17	74053353	74053432	-	intron-Distal,intron-Proximal	5.14934	7.21051	K562	PRPF8
chr17	74039834	74039896	-	intron-Distal,intron-Proximal	5.77957	21.77166	K562	AQR
chr17	74058291	74058373	-	intron-Distal	4.82308	5.78422	HepG2	ILF3
chr17	74066872	74066948	-	intron-Distal	4.62863	6.71516	K562	TARDBP
chr17	74053195	74053315	-	intron-Distal	3.75462	3.39362	HepG2	CSTF2
chr17	74057530	74057554	-	intron-Distal,intron-Proximal	4.78459	4.65563	K562	AQR
chr17	74046464	74046509	-	intron-Distal,intron-Proximal	3.49552	6.25527	HepG2	PRPF8
chr17	74057147	74057173	-	intron-Distal,intron-Proximal	4.66280	4.94356	HepG2	PRPF8
chr17	74037060	74037098	-	intron-Distal,intron-Proximal	6.34223	19.37666	HepG2	SF3B4
chr17	74057554	74057573	-	intron-Distal,intron-Proximal	3.22715	3.94787	K562	AQR
chr17	74037061	74037131	-	intron-Distal,intron-Proximal	4.09031	4.49024	K562	AQR
chr17	74043309	74043378	-	intron-Distal	3.05444	3.40404	HepG2	ILF3
chr17	74039071	74039155	-	intron-Distal	3.90331	3.72818	HepG2	ILF3
chr17	74041127	74041180	-	intron-Distal	5.02918	5.56788	K562	SMNDC1
chr17	74058457	74058532	-	intron-Distal	5.26169	9.38594	HepG2	ILF3
chr17	74046644	74046729	-	intron-Distal,intron-Proximal	4.41906	5.44904	K562	TARDBP
chr17	74037098	74037109	-	intron-Distal,intron-Proximal	6.24315	17.99892	HepG2	SF3B4
chr17	74043594	74043691	-	intron-Distal	4.30879	3.37208	HepG2	ILF3
chr17	74039896	74039910	-	intron-Distal,intron-Proximal	6.06086	12.46873	K562	AQR
chr17	74046436	74046480	-	intron-Distal,intron-Proximal	5.01650	5.56495	HepG2	RBM22
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

eCLIP assay for SRP68 is not avaliable on ENCORE database.

Diffrential Expression

945 differentially expressed genes after Knockdown/Knockout SRP68 protein.

73 RBPs can affect the levels of SRP68.

945 differentially expressed genes after Knockdown/Knockout SRP68 protein :

Only display 100 entries as example. Please click "View All" button to see all 945 entries.

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
TFPI	ENSG00000003436.10	6996.22000	5193.24570	0.42980	4.92080	2.86270	HepG2	SRP68
SKAP2	ENSG00000005020.8	338.28200	627.62370	-0.89170	7.97220	5.44120	HepG2	SRP68
ACSM3	ENSG00000005187.7	731.01860	500.52310	0.54640	3.54210	1.70890	HepG2	SRP68
ITGA3	ENSG00000005884.13	44.11180	155.70610	-1.81960	10.58140	7.83070	HepG2	SRP68
GDE1	ENSG00000006007.7	852.35270	1423.24830	-0.73970	8.13480	5.59750	HepG2	SRP68
MAP3K9	ENSG00000006432.11	355.18640	517.76310	-0.54370	3.19450	1.44280	HepG2	SRP68
ST3GAL1	ENSG00000008513.10	1367.07660	878.29280	0.63820	5.49310	3.34450	HepG2	SRP68
BAZ1B	ENSG00000009954.6	1968.89710	2919.70420	-0.56840	5.32430	3.20140	HepG2	SRP68
SEMA3G	ENSG00000010319.2	748.48470	384.44370	0.96110	9.73480	7.03420	HepG2	SRP68
NME2	ENSG00000011052.17	520.99420	174.20390	1.58040	4.88130	2.83260	HepG2	SRP68
MBTD1	ENSG00000011258.11	1331.39740	970.56280	0.45590	3.63500	1.78210	HepG2	SRP68
TACC3	ENSG00000013810.14	798.96840	1091.94420	-0.45070	3.40710	1.60000	HepG2	SRP68
CHDH	ENSG00000016391.6	2766.97240	2054.90370	0.42910	3.06920	1.36000	HepG2	SRP68
CYP24A1	ENSG00000019186.5	277.21980	686.09550	-1.30740	16.05040	12.83310	HepG2	SRP68
HSD17B6	ENSG00000025423.7	57.36350	17.17500	1.73970	3.14810	1.41400	HepG2	SRP68
TOMM34	ENSG00000025772.7	872.48870	1285.52290	-0.55910	4.94260	2.87800	HepG2	SRP68
RNASET2	ENSG00000026297.11	2972.36390	1972.21010	0.59170	6.45400	4.13590	HepG2	SRP68
FUT8	ENSG00000033170.12	408.28940	588.86130	-0.52830	3.02750	1.33250	HepG2	SRP68
RNF19A	ENSG00000034677.7	1168.10740	709.00880	0.72020	7.50550	5.01130	HepG2	SRP68
VCL	ENSG00000035403.12	553.82560	1070.21100	-0.95040	11.41200	8.53990	HepG2	SRP68
HSPA5	ENSG00000044574.7	30890.77480	24166.83290	0.35400	3.47920	1.65640	HepG2	SRP68
CP	ENSG00000047457.9	26555.16620	16672.60750	0.67140	10.63270	7.87130	HepG2	SRP68
TSPAN17	ENSG00000048140.13	250.66650	393.40160	-0.65020	3.69090	1.82990	HepG2	SRP68
ADAMTS6	ENSG00000049192.10	297.54110	189.84840	0.64810	3.23210	1.46860	HepG2	SRP68
HEBP2	ENSG00000051620.6	514.72800	795.87840	-0.62870	4.27580	2.32400	HepG2	SRP68
MSMO1	ENSG00000052802.8	6082.80180	4227.83590	0.52470	4.24280	2.29770	HepG2	SRP68
FOXN3	ENSG00000053254.11	2839.42240	2075.92000	0.45170	4.09700	2.16970	HepG2	SRP68
LAMA3	ENSG00000053747.11	59.65870	118.61380	-0.99150	3.02780	1.33250	HepG2	SRP68
DCBLD2	ENSG00000057019.11	2422.66220	4085.44440	-0.75390	7.53920	5.03910	HepG2	SRP68
CREB3L3	ENSG00000060566.9	270.94180	136.39310	0.99010	4.91170	2.85570	HepG2	SRP68
DGAT2	ENSG00000062282.10	533.36450	844.67390	-0.66330	5.59650	3.42340	HepG2	SRP68
NGFR	ENSG00000064300.4	54.83560	185.24420	-1.75620	9.41880	6.76290	HepG2	SRP68
CTSA	ENSG00000064601.12	3417.63900	4325.38570	-0.33980	3.09440	1.37660	HepG2	SRP68
TIE1	ENSG00000066056.9	27.86210	115.87470	-2.05620	9.02790	6.42790	HepG2	SRP68
KLF6	ENSG00000067082.10	1274.35670	1798.30910	-0.49690	3.20570	1.44980	HepG2	SRP68
CYFIP1	ENSG00000068793.13	949.00170	1387.69920	-0.54820	4.85140	2.81430	HepG2	SRP68
NUCKS1	ENSG00000069275.12	3987.48540	5775.98810	-0.53460	5.18540	3.07720	HepG2	SRP68
TGFBR3	ENSG00000069702.6	6541.06170	4906.14560	0.41480	3.22350	1.46330	HepG2	SRP68
GSDMB	ENSG00000073605.14	493.70250	346.48390	0.51080	3.09260	1.37660	HepG2	SRP68
WDR62	ENSG00000075702.12	336.45340	470.79310	-0.48470	2.99920	1.31280	HepG2	SRP68
PLXNA2	ENSG00000076356.6	144.36720	228.14610	-0.66020	3.04250	1.34180	HepG2	SRP68
TNS1	ENSG00000079308.12	2290.42630	940.23490	1.28440	23.17300	19.50860	HepG2	SRP68
PTPRH	ENSG00000080031.5	909.24230	600.68510	0.59800	5.17670	3.07100	HepG2	SRP68
CPB2	ENSG00000080618.9	2342.05500	1767.31190	0.40610	3.33330	1.54740	HepG2	SRP68
AFP	ENSG00000081051.3	149319.78520	92544.43650	0.69010	10.87830	8.08310	HepG2	SRP68
HAL	ENSG00000084110.6	477.07900	170.67180	1.48290	14.71660	11.60850	HepG2	SRP68
KIAA1467	ENSG00000084444.9	351.11210	224.33170	0.64620	3.33100	1.54730	HepG2	SRP68
AURKA	ENSG00000087586.13	1930.08550	2740.91830	-0.50600	5.05720	2.97250	HepG2	SRP68
TPX2	ENSG00000088325.11	3063.68490	4200.17720	-0.45520	4.36480	2.38880	HepG2	SRP68
FER1L4	ENSG00000088340.11	272.39310	166.52910	0.70980	3.19630	1.44300	HepG2	SRP68
BIRC5	ENSG00000089685.10	1299.83430	1986.52870	-0.61190	6.67100	4.32470	HepG2	SRP68
SLC9A1	ENSG00000090020.6	153.07840	250.86420	-0.71260	3.38950	1.59310	HepG2	SRP68
TF	ENSG00000091513.10	136677.23750	104593.45290	0.38590	3.54520	1.70940	HepG2	SRP68
SCD	ENSG00000099194.5	69791.55700	54780.04950	0.34930	3.39690	1.59540	HepG2	SRP68
SERPIND1	ENSG00000099937.6	11594.21260	6714.68460	0.78790	12.20050	9.26850	HepG2	SRP68
MMP11	ENSG00000099953.5	690.13620	278.67040	1.30820	7.45770	4.96930	HepG2	SRP68
MFNG	ENSG00000100060.13	115.85090	51.59010	1.16700	3.41350	1.60300	HepG2	SRP68
APOL1	ENSG00000100342.16	4239.95470	3062.50170	0.46920	3.72810	1.85460	HepG2	SRP68
FOXRED2	ENSG00000100350.10	1022.51800	1482.80180	-0.53620	5.07520	2.98820	HepG2	SRP68
C14orf105	ENSG00000100557.5	33.62250	90.81400	-1.43350	4.16650	2.23280	HepG2	SRP68
ISM2	ENSG00000100593.13	765.29850	528.66390	0.53360	2.99550	1.31060	HepG2	SRP68
LGMN	ENSG00000100600.10	1169.23360	854.16470	0.45290	2.99400	1.31000	HepG2	SRP68
ITPK1	ENSG00000100605.12	400.88830	613.93790	-0.61490	3.34460	1.55520	HepG2	SRP68
SRSF5	ENSG00000100650.11	4903.51920	3640.53360	0.42960	4.48760	2.50260	HepG2	SRP68
EEF1A2	ENSG00000101210.6	85.50640	211.37390	-1.30570	6.83620	4.46840	HepG2	SRP68
FAM83D	ENSG00000101447.9	763.42610	1099.68720	-0.52650	4.47780	2.49630	HepG2	SRP68
STAG2	ENSG00000101972.14	1184.68540	1637.87190	-0.46730	3.29270	1.51930	HepG2	SRP68
PGK1	ENSG00000102144.9	19356.69270	15344.81870	0.33500	3.40530	1.59940	HepG2	SRP68
SMS	ENSG00000102172.11	779.11460	1393.02820	-0.83830	9.26690	6.62780	HepG2	SRP68
PCYT1B	ENSG00000102230.9	291.59500	430.49070	-0.56200	3.18080	1.43330	HepG2	SRP68
GABRE	ENSG00000102287.12	1347.22970	767.61710	0.81140	7.80730	5.28270	HepG2	SRP68
NDRG4	ENSG00000103034.10	130.97670	222.12870	-0.76210	3.46170	1.64360	HepG2	SRP68
COTL1	ENSG00000103187.6	399.34510	673.67700	-0.75440	6.42870	4.11830	HepG2	SRP68
CORO2B	ENSG00000103647.8	13.43920	47.04460	-1.80760	3.37720	1.58320	HepG2	SRP68
KIAA1199	ENSG00000103888.11	856.33360	1568.45020	-0.87310	10.73980	7.95610	HepG2	SRP68
NDRG1	ENSG00000104419.10	6926.62610	4453.44750	0.63710	9.06390	6.45340	HepG2	SRP68
SQLE	ENSG00000104549.7	6573.60720	4944.83660	0.41070	3.13020	1.40220	HepG2	SRP68
FGL1	ENSG00000104760.12	9134.13860	5646.19450	0.69390	5.94480	3.72120	HepG2	SRP68
SULT2A1	ENSG00000105398.3	2261.88970	1644.83140	0.45950	4.10350	2.17460	HepG2	SRP68
HPN	ENSG00000105707.9	1896.31230	949.75740	0.99750	4.87860	2.83260	HepG2	SRP68
CDK6	ENSG00000105810.5	4130.26690	3191.80210	0.37180	3.56200	1.72490	HepG2	SRP68
HIBADH	ENSG00000106049.4	680.07290	994.28490	-0.54800	3.79650	1.91170	HepG2	SRP68
CPVL	ENSG00000106066.9	2897.45140	2036.90070	0.50830	4.79410	2.76110	HepG2	SRP68
GRB10	ENSG00000106070.13	323.24820	537.47260	-0.73350	4.93360	2.87120	HepG2	SRP68
TFR2	ENSG00000106327.8	1163.88110	564.01790	1.04500	3.72570	1.85370	HepG2	SRP68
C5	ENSG00000106804.6	14567.04630	6898.39190	1.07830	17.98040	14.61700	HepG2	SRP68
AMBP	ENSG00000106927.7	22486.43350	16857.12690	0.41560	3.49750	1.66940	HepG2	SRP68
ABCA2	ENSG00000107331.12	809.82960	538.55750	0.58840	3.46870	1.64940	HepG2	SRP68
CCNJ	ENSG00000107443.11	389.74210	580.43640	-0.57460	3.07490	1.36280	HepG2	SRP68
PALD1	ENSG00000107719.8	8.75670	35.75050	-2.02950	2.99110	1.30890	HepG2	SRP68
DNAJC12	ENSG00000108176.10	337.95420	177.61540	0.92800	5.79790	3.59290	HepG2	SRP68
KRT23	ENSG00000108244.12	267.29270	736.14560	-1.46160	19.89880	16.38040	HepG2	SRP68
PFN1	ENSG00000108518.7	3964.86790	5246.47260	-0.40410	3.23080	1.46840	HepG2	SRP68
CPD	ENSG00000108582.7	6607.86890	4633.60050	0.51200	6.04850	3.79230	HepG2	SRP68
RAB5C	ENSG00000108774.10	1511.11060	2070.74010	-0.45450	4.28050	2.32610	HepG2	SRP68
COL1A1	ENSG00000108821.9	33.34120	133.72220	-2.00390	6.13940	3.86940	HepG2	SRP68
ABCC3	ENSG00000108846.11	820.17600	1239.22220	-0.59540	5.72000	3.52970	HepG2	SRP68
FAM20A	ENSG00000108950.7	353.91950	190.65730	0.89230	4.76130	2.73030	HepG2	SRP68
VTN	ENSG00000109072.9	4202.20920	2757.62550	0.60760	4.85520	2.81610	HepG2	SRP68
UGT2B10	ENSG00000109181.7	3272.18030	2134.98350	0.61590	6.18950	3.91250	HepG2	SRP68
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

73 RBPs can affect the gene expression of SRP68 :

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
SRP68	ENSG00000167881.10	4343.01750	3358.85430	0.37060	2.65100	2.12980	HepG2	AKAP1
SRP68	ENSG00000167881.10	1800.04360	2394.95840	-0.41200	7.43540	6.24710	HepG2	AKAP8L
SRP68	ENSG00000167881.10	1415.24150	2110.02090	-0.57620	9.27330	7.98450	HepG2	CALR
SRP68	ENSG00000167881.10	1629.73120	2055.23660	-0.33470	3.40800	2.38810	HepG2	DDX24
SRP68	ENSG00000167881.10	1256.54230	1780.88010	-0.50310	4.85090	3.04520	HepG2	DDX28
SRP68	ENSG00000167881.10	1225.39690	1561.46610	-0.34970	3.28980	1.81430	HepG2	DDX52
SRP68	ENSG00000167881.10	1888.78220	2350.94550	-0.31580	1.99400	1.32630	HepG2	DDX55
SRP68	ENSG00000167881.10	1913.29350	2280.70470	-0.25340	3.14530	2.43000	HepG2	DKC1
SRP68	ENSG00000167881.10	1713.14450	2019.78950	-0.23760	2.41850	1.75580	HepG2	DNAJC21
SRP68	ENSG00000167881.10	1555.24580	2001.89900	-0.36420	7.01150	6.03970	HepG2	DNAJC2
SRP68	ENSG00000167881.10	1963.87000	2656.94330	-0.43610	3.83870	3.14780	HepG2	EIF2S1
SRP68	ENSG00000167881.10	1640.20770	2858.93440	-0.80160	7.84470	6.71610	HepG2	EIF4B
SRP68	ENSG00000167881.10	1866.24370	3992.45160	-1.09710	52.17070	50.18630	HepG2	ETF1
SRP68	ENSG00000167881.10	1870.33780	2329.34440	-0.31660	3.02840	2.15640	HepG2	EWSR1
SRP68	ENSG00000167881.10	1740.35630	2483.43400	-0.51300	3.43510	2.18910	HepG2	FUS
SRP68	ENSG00000167881.10	2140.25300	2748.21740	-0.36070	2.61640	1.96900	HepG2	G3BP1
SRP68	ENSG00000167881.10	2332.85060	2917.80290	-0.32280	2.47350	1.63290	HepG2	G3BP2
SRP68	ENSG00000167881.10	1863.63330	2321.16440	-0.31670	2.07930	1.52030	HepG2	GPKOW
SRP68	ENSG00000167881.10	1704.55770	2275.83950	-0.41700	7.63670	6.11360	HepG2	HDGF
SRP68	ENSG00000167881.10	1255.40510	2039.13900	-0.69980	10.78380	9.63480	HepG2	HNRNPA1
SRP68	ENSG00000167881.10	1133.25900	1583.01210	-0.48220	3.31930	1.78790	HepG2	HNRNPAB
SRP68	ENSG00000167881.10	2406.90380	2757.30480	-0.19610	2.49960	1.81690	HepG2	HNRNPF
SRP68	ENSG00000167881.10	2905.40770	3415.73380	-0.23350	3.82250	3.03820	HepG2	HNRNPL
SRP68	ENSG00000167881.10	1456.37020	2215.13480	-0.60500	7.07350	6.12030	HepG2	HNRNPLL
SRP68	ENSG00000167881.10	1929.75280	2253.15260	-0.22350	2.65690	2.06210	HepG2	HNRNPU
SRP68	ENSG00000167881.10	2030.65750	2301.52390	-0.18060	2.23500	1.56800	HepG2	ILF2
SRP68	ENSG00000167881.10	1875.80590	2809.83780	-0.58300	4.83620	3.47650	HepG2	KHSRP
SRP68	ENSG00000167881.10	1847.93790	2179.07800	-0.23780	3.47940	2.33660	HepG2	KIF1C
SRP68	ENSG00000167881.10	1593.87410	2259.26590	-0.50330	3.06650	2.04280	HepG2	MTPAP
SRP68	ENSG00000167881.10	3041.49880	3718.40230	-0.28990	3.29120	2.46110	HepG2	NOL12
SRP68	ENSG00000167881.10	1852.44980	2230.25820	-0.26780	3.42760	2.49430	HepG2	PARN
SRP68	ENSG00000167881.10	2508.04640	2858.97620	-0.18890	1.98340	1.50650	HepG2	PTBP1
SRP68	ENSG00000167881.10	2245.81000	3549.65550	-0.66040	11.32080	10.22540	HepG2	PUF60
SRP68	ENSG00000167881.10	2795.84740	3768.25080	-0.43060	12.41990	11.35460	HepG2	PUM1
SRP68	ENSG00000167881.10	3164.80480	3765.41450	-0.25070	2.41350	1.78650	HepG2	PUM2
SRP68	ENSG00000167881.10	2894.62110	3336.94690	-0.20520	2.13600	1.66550	HepG2	RBM22
SRP68	ENSG00000167881.10	2387.23860	2810.05580	-0.23530	1.93390	1.36180	HepG2	RBM25
SRP68	ENSG00000167881.10	1764.57840	2438.44300	-0.46660	4.34660	3.08490	HepG2	RBM27
SRP68	ENSG00000167881.10	2545.17870	3181.71200	-0.32200	5.21710	4.51240	HepG2	NELFE
SRP68	ENSG00000167881.10	2542.84530	2963.43030	-0.22080	2.73180	2.11900	HepG2	RECQL
SRP68	ENSG00000167881.10	1759.74810	2295.62560	-0.38350	3.10450	1.96120	HepG2	RPS5
SRP68	ENSG00000167881.10	3914.63860	2932.63500	0.41660	2.63790	1.98000	HepG2	SF3A3
SRP68	ENSG00000167881.10	1958.32760	2976.44660	-0.60400	16.09270	14.84590	HepG2	SF3B4
SRP68	ENSG00000167881.10	2616.25980	3403.84280	-0.37970	8.83290	7.69180	HepG2	SLBP
SRP68	ENSG00000167881.10	1929.68580	2339.98610	-0.27810	4.96720	4.14650	HepG2	SMN1
SRP68	ENSG00000167881.10	912.24180	2239.11850	-1.29540	24.99070	21.22930	HepG2	SRP68
SRP68	ENSG00000167881.10	4448.38150	3106.81350	0.51770	15.48980	14.56520	HepG2	SRSF1
SRP68	ENSG00000167881.10	2731.79770	3504.92920	-0.35950	6.38360	5.48640	HepG2	SRSF5
SRP68	ENSG00000167881.10	2243.69390	2527.59930	-0.17190	1.82450	1.35850	HepG2	SRSF9
SRP68	ENSG00000167881.10	4266.41940	3272.33080	0.38260	8.71720	7.90700	HepG2	SSB
SRP68	ENSG00000167881.10	2953.04380	3985.93190	-0.43270	11.37790	10.26150	HepG2	SUCLG1
SRP68	ENSG00000167881.10	1727.11340	2340.29880	-0.43830	3.44880	2.70400	HepG2	SUPV3L1
SRP68	ENSG00000167881.10	2407.34530	2792.65720	-0.21420	2.21390	1.70260	HepG2	TAF15
SRP68	ENSG00000167881.10	1542.26900	2159.21160	-0.48550	5.27760	4.32130	HepG2	TARDBP
SRP68	ENSG00000167881.10	1242.25730	1568.60120	-0.33650	2.58930	1.62190	HepG2	TFIP11
SRP68	ENSG00000167881.10	1728.95520	2208.92560	-0.35340	5.61990	4.86850	HepG2	TRIM56
SRP68	ENSG00000167881.10	2660.59400	3468.08310	-0.38240	4.48670	3.34260	HepG2	TUFM
SRP68	ENSG00000167881.10	2615.62220	3671.05600	-0.48900	4.35880	3.29280	HepG2	UBE2L3
SRP68	ENSG00000167881.10	3044.54650	2510.96810	0.27790	4.34680	3.62330	HepG2	UTP3
SRP68	ENSG00000167881.10	3180.88630	2860.38030	0.15310	2.07130	1.57930	HepG2	ZNF622
SRP68	ENSG00000167881.10	1844.52720	2191.91460	-0.24890	3.03270	2.44250	K562	AGGF1
SRP68	ENSG00000167881.10	848.04330	1099.72310	-0.37490	2.79710	1.73630	K562	CCAR1
SRP68	ENSG00000167881.10	3744.37410	2840.44000	0.39850	8.09690	7.05960	K562	DDX47
SRP68	ENSG00000167881.10	1874.56390	1465.85320	0.35470	4.26680	3.28900	K562	EIF3G
SRP68	ENSG00000167881.10	1045.83890	1295.93250	-0.30930	2.61190	1.30930	K562	FUS
SRP68	ENSG00000167881.10	2439.63030	1695.96180	0.52450	10.13730	9.06300	K562	FXR1
SRP68	ENSG00000167881.10	1737.41460	2311.21690	-0.41170	4.96310	3.54110	K562	HNRNPA1
SRP68	ENSG00000167881.10	2351.00810	1813.92810	0.37410	2.75890	1.83050	K562	HNRNPM
SRP68	ENSG00000167881.10	989.50910	1304.16090	-0.39830	2.28640	1.44670	K562	KRR1
SRP68	ENSG00000167881.10	2201.70210	2529.20470	-0.20010	3.18450	2.38790	K562	NSUN2
SRP68	ENSG00000167881.10	2648.84620	1755.19970	0.59360	7.61640	6.36640	K562	PRPF8
SRP68	ENSG00000167881.10	2381.22110	1997.34410	0.25350	2.22490	1.61920	K562	PTBP1
SRP68	ENSG00000167881.10	3784.31230	4401.04190	-0.21780	2.47900	1.56910	K562	PUM2
SRP68	ENSG00000167881.10	2439.93930	1787.99980	0.44840	3.79540	2.83540	K562	RPS19
SRP68	ENSG00000167881.10	2171.15910	2495.71590	-0.20100	2.06890	1.35650	K562	SF3A3
SRP68	ENSG00000167881.10	1350.37900	1660.03710	-0.29790	2.87480	2.00230	K562	SF3B4
SRP68	ENSG00000167881.10	862.30130	1752.51400	-1.02320	18.00560	13.93510	K562	SRP68
SRP68	ENSG00000167881.10	3202.99730	1958.07540	0.70990	14.11260	12.51160	K562	SRSF1
SRP68	ENSG00000167881.10	2190.34040	1745.01680	0.32780	3.53080	2.60290	K562	SYNCRIP
SRP68	ENSG00000167881.10	1292.30540	1655.96680	-0.35770	2.26800	1.42450	K562	TRIM56
SRP68	ENSG00000167881.10	1424.53340	1798.75010	-0.33650	2.35440	1.42350	K562	UCHL5
SRP68	ENSG00000167881.10	1815.35210	2294.70380	-0.33810	3.43930	2.46610	K562	WDR3
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

The Knockdown/knockout RNA-Seq assay for SRP68 is not available on ENCORE database.

6 RBPs can affect the splicing of SRP68 :

Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	2ndExonStart	2ndExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	p-value	FDR	is_included	Cell Line	Affected by RBP
SE	SRP68	ENSG00000167881.10	chr17	-	74057572	74057655			74057190	74057300	74060056	74060252	-0.10400	0.00003	0.00102	excluded	K562	SF3B4
SE	SRP68	ENSG00000167881.10	chr17	-	74057572	74057655			74053483	74053624	74060056	74060252	-0.37800	0.00005	0.00100	excluded	HepG2	U2AF2
SE	SRP68	ENSG00000167881.10	chr17	-	74057572	74057655			74057190	74057300	74060056	74060252	-0.06300	0.00000	0.00008	excluded	K562	AQR
SE	SRP68	ENSG00000167881.10	chr17	-	74057572	74057734			74057255	74057300	74060056	74060210	-0.06700	0.00085	0.02698	excluded	HepG2	SF3A3
SE	SRP68	ENSG00000167881.10	chr17	-	74057572	74057655			74057190	74057300	74060056	74060252	-0.05500	0.00073	0.03664	excluded	HepG2	SF3B4
A3SS	SRP68	ENSG00000167881.10	chr17	-	74036983	74037220			74036983	74037059	74039909	74040102	0.06100	0.00000	0.00000	longer	K562	AQR
A3SS	SRP68	ENSG00000167881.10	chr17	-	74057572	74057680			74057572	74057655	74060056	74060252	0.09700	0.00000	0.00000	longer	K562	AQR
A3SS	SRP68	ENSG00000167881.10	chr17	-	74039909	74040102			74039909	74040039	74041372	74041597	0.08200	0.00000	0.00000	longer	K562	AQR
A3SS	SRP68	ENSG00000167881.10	chr17	-	74041372	74041597			74041372	74041467	74042118	74042352	0.08300	0.00000	0.00000	longer	K562	AQR
A3SS	SRP68	ENSG00000167881.10	chr17	-	74063297	74063447			74063297	74063411	74066458	74066525	0.09100	0.00000	0.00000	longer	K562	AQR
MXE	SRP68	ENSG00000167881.10	chr17	-	74036983	74037059	74039909	74040039	74036499	74036555	74041372	74041467	-0.10300	0.00457	0.07640	2included	HepG2	DDX55
MXE	SRP68	ENSG00000167881.10	chr17	-	74036983	74037059	74039909	74040039	74036499	74036555	74041372	74041467	-0.14600	0.00075	0.06979	2included	K562	EWSR1

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

SRP68

General Information

Functions

Localization(RBPImage: SRP68)

Domains (AlphaFold: SRP68)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

eCLIP assay for SRP68 is not avaliable on ENCORE database.

21 proteins are bound to SRP68 RNA:

eCLIP assay for SRP68 is not avaliable on ENCORE database.

Diffrential Expression

945 differentially expressed genes after Knockdown/Knockout SRP68 protein :

73 RBPs can affect the gene expression of SRP68 :

The Knockdown/knockout RNA-Seq assay for SRP68 is not available on ENCORE database.

6 RBPs can affect the splicing of SRP68 :

The Knockdown/knockout RNA-Seq assay for SRP68 is not avaliable on ENCORE database.