TMEM59

General Information

Gene Name       : TMEM59
Gene ID             : ENSG00000116209.11
Essential Gene : No

Functions

Localization

Domains (AlphaFold: TMEM59)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878TMEM59ENSG00000116209.1152.7947.6050.20ENCSR000AEF
HepG2TMEM59ENSG00000116209.1187.13100.2993.71ENCSR985KAT
K562TMEM59ENSG00000116209.1198.1689.1993.67ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for TMEM59 is not avaliable on ENCORE database.



Proteins bound to RNA
  • TMEM59 RNA is bound by 20 proteins.  







eCLIP assay for TMEM59 is not avaliable on ENCORE database.





20 proteins are bound to TMEM59 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr15449747654497557-3'-UTR,intron-Distal,intron-Proximal3.514744.63751K562IGF2BP1
chr15449756754497584-3'-UTR,intron-Distal,intron-Proximal3.991773.04397HepG2TIA1
chr15449745754497596-3'-UTR,intron-Distal,intron-Proximal3.171203.27901HepG2UPF1
chr15449771654497804-3'-UTR,intron-Distal3.4592511.39088K562PABPC4
chr15450917554509199-3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal3.065919.60340K562YBX3
chr15449749554497538-3'-UTR,intron-Distal3.337477.28132HepG2TIAL1
chr15449753954497563-3'-UTR,intron-Distal,intron-Proximal3.401818.29087HepG2TIAL1
chr15449748354497530-3'-UTR,intron-Distal4.7986921.50903K562TIA1
chr15449753054497578-3'-UTR,intron-Distal,intron-Proximal5.1051730.75511K562TIA1
chr15449770754497803-3'-UTR,intron-Distal4.716945.54754K562IGF2BP1
chr15449781754497846-3'-UTR,CDS,intron-Distal3.917803.65750K562YBX3
chr15451125254511343-3'-UTR,CDS,intron-Distal,intron-Proximal4.577426.51328K562KHSRP
chr15449740854497473-3'-UTR,intron-Distal3.987113.74511K562IGF2BP1
chr15449749654497575-3'-UTR,intron-Distal,intron-Proximal3.4638013.36224HepG2DDX55
chr15449749254497567-3'-UTR,intron-Distal,intron-Proximal6.5402622.20478HepG2TIA1
chr15451868354518881-5'-UTR,CDS,intron-Distal,intron-Proximal4.0213322.85836K562RPS3
chr15451136454511460-5'-UTR,CDS,intron-Distal,intron-Proximal3.5417817.21850K562SND1
chr15451299654513069-5'-UTR,CDS,intron-Distal,intron-Proximal4.535358.14995HepG2U2AF2
chr15451141354511512-5'-UTR,CDS,intron-Distal,intron-Proximal4.2228111.47331K562SF3B4
chr15451306054513127-5'-UTR,intron-Distal,intron-Proximal4.4953411.25076K562QKI
chr15451300054513059-5'-UTR,CDS,intron-Distal,intron-Proximal3.304323.39327K562U2AF2
chr15451873854518871-5'-UTR,CDS,intron-Distal,intron-Proximal4.8696421.95390K562DDX3X
chr15451293854512980-5'-UTR,CDS,intron-Distal,intron-Proximal3.345059.44204K562SND1
chr15451297554513046-5'-UTR,CDS,intron-Distal,intron-Proximal4.353484.15726HepG2G3BP1
chr15450926054509341-5'-UTR,intron-Distal,intron-Proximal4.805508.27925K562KHSRP
chr15451307154513143-5'-UTR,intron-Distal,intron-Proximal4.660115.13577HepG2U2AF2
chr15451873954518863-5'-UTR,CDS,intron-Distal4.8434649.41302HepG2DDX3X
chr15451307954513138-5'-UTR,intron-Distal,intron-Proximal3.524523.64762HepG2QKI
chr15451298054513039-5'-UTR,CDS,intron-Distal3.161776.67848K562SND1
chr15450904454509060-CDS,intron-Distal,intron-Proximal3.120628.56198K562YBX3
chr15450740454507462-CDS,intron-Distal5.122704.55355HepG2SND1
chr15451872454518861-CDS,intron-Distal4.8045516.49042HepG2RPS3
chr15450904554509098-CDS,intron-Distal,intron-Proximal3.9062015.99770K562SND1
chr15449783854497883-CDS,intron-Distal3.728454.95361HepG2SND1
chr15450228254502347-CDS,intron-Distal,intron-Proximal4.8942028.18544K562SND1
chr15451867654518738-CDS,intron-Distal3.5803310.87648K562DDX3X
chr15450234854502391-CDS,intron-Distal3.929088.93416K562SND1
chr15449784554497940-CDS,intron-Distal4.4182116.31024K562SND1
chr15450642854506446-CDS,intron-Distal,intron-Proximal3.001533.14823K562SND1
chr15450910054509180-CDS,intron-Distal4.4300220.07174K562SND1
chr15450899754509082-CDS,intron-Distal,intron-Proximal3.100915.75838K562PRPF8
chr15450647054506506-CDS,intron-Distal5.563597.85641K562SND1
chr15449795854497978-CDS,intron-Distal4.9210712.13141K562SND1
chr15450739254507480-CDS,intron-Distal,intron-Proximal3.173503.02821K562IGF2BP1
chr15451867654518724-CDS,intron-Distal5.275113.98437HepG2RPS3
chr15450740054507463-CDS,intron-Distal3.8101115.67975K562SND1
chr15450904254509165-CDS,intron-Distal,intron-Proximal3.121776.04751HepG2GRWD1
chr15451867354518740-CDS,intron-Distal3.891594.80676K562RBM15
chr15450746354507479-CDS,intron-Distal,intron-Proximal3.4808912.82284K562SND1
chr15450228254502391-CDS,intron-Distal,intron-Proximal4.027864.74485HepG2YBX3
chr15450639054506461-CDS,intron-Distal,intron-Proximal4.324936.75234K562PRPF8
chr15451868054518731-CDS,intron-Distal4.2751910.34792HepG2DDX3X
chr15451868854518746-CDS,intron-Distal4.154884.31023HepG2LIN28B
chr15451437854514429-intron-Distal,intron-Proximal4.172843.80778HepG2QKI
chr15451811154518161-intron-Distal3.109823.31224K562HNRNPA1
chr15450497154505064-intron-Distal3.638553.02234K562KHSRP
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for TMEM59 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for TMEM59 is not available on ENCORE database.

  • 94 RBPs can affect the levels of TMEM59.  








The Knockdown/knockout RNA-Seq assay for TMEM59 is not available on ENCORE database.





94 RBPs can affect the gene expression of TMEM59 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
TMEM59ENSG00000116209.72050.113201584.793500.371302.601301.59330HepG2AKAP8
TMEM59ENSG00000116209.73358.115202169.072900.6305018.0997016.37310HepG2AKAP8L
TMEM59ENSG00000116209.73399.634703021.553900.170001.972301.37570HepG2AUH
TMEM59ENSG00000116209.72165.191801542.019400.489604.625303.48660HepG2BCLAF1
TMEM59ENSG00000116209.71534.898601191.658100.365103.141302.50770HepG2BOP1
TMEM59ENSG00000116209.72479.655301665.117500.574409.793108.47460HepG2CALR
TMEM59ENSG00000116209.74204.922103481.749000.272202.034501.36530HepG2CIRBP
TMEM59ENSG00000116209.72561.091502158.454800.246703.918203.15320HepG2CKAP4
TMEM59ENSG00000116209.73318.950902346.415700.500202.914602.12970HepG2CNOT7
TMEM59ENSG00000116209.71328.028101094.039200.279501.887301.30800HepG2CPSF6
TMEM59ENSG00000116209.71880.014901518.141500.308302.399701.37250HepG2CPSF7
TMEM59ENSG00000116209.73396.586902759.581600.299504.282903.51470HepG2CELF1
TMEM59ENSG00000116209.73828.624002967.382100.367509.148807.92440HepG2DAZAP1
TMEM59ENSG00000116209.76517.655704242.851900.619207.809906.80910HepG2DDX3X
TMEM59ENSG00000116209.7962.045401344.66840-0.483105.374403.56050HepG2DDX52
TMEM59ENSG00000116209.72131.452401556.613400.453305.016203.71710HepG2DHX30
TMEM59ENSG00000116209.74309.131703503.745300.298402.146201.61670HepG2EIF2S1
TMEM59ENSG00000116209.71654.792401302.273100.345502.521101.65350HepG2EIF3D
TMEM59ENSG00000116209.72537.890102927.37160-0.206002.608001.79210HepG2EIF4G1
TMEM59ENSG00000116209.73946.148202804.258500.492705.204004.10650HepG2EIF4G2
TMEM59ENSG00000116209.74630.868403468.962200.416709.076208.09230HepG2ETF1
TMEM59ENSG00000116209.72482.006501861.930900.414602.963102.16760HepG2FIP1L1
TMEM59ENSG00000116209.71834.436801095.847700.743203.291202.18000HepG2FTO
TMEM59ENSG00000116209.72655.096603906.45280-0.557106.294505.27700HepG2FXR1
TMEM59ENSG00000116209.72733.673503847.08160-0.492905.257204.01670HepG2G3BP2
TMEM59ENSG00000116209.71620.748401240.266500.385902.734302.09660HepG2GPKOW
TMEM59ENSG00000116209.72198.640001812.365100.278602.191501.56650HepG2HNRNPC
TMEM59ENSG00000116209.73312.375102703.104800.293105.750404.80960HepG2HNRNPL
TMEM59ENSG00000116209.72270.600401183.601200.939809.670508.57360HepG2HNRNPLL
TMEM59ENSG00000116209.71474.847401800.38550-0.287702.816302.20410HepG2HNRNPU
TMEM59ENSG00000116209.72064.701301670.835500.305302.923902.18110HepG2IGF2BP1
TMEM59ENSG00000116209.72294.431703683.82870-0.683108.868407.73550HepG2IGF2BP2
TMEM59ENSG00000116209.72645.040703705.15320-0.486203.584702.42280HepG2KHSRP
TMEM59ENSG00000116209.72368.784501973.536900.263304.326403.06080HepG2KIF1C
TMEM59ENSG00000116209.72909.618503907.81470-0.425503.734802.97280HepG2MAGOH
TMEM59ENSG00000116209.72633.949403929.75550-0.577205.820404.93040HepG2MATR3
TMEM59ENSG00000116209.72036.527001506.507000.434804.549403.53140HepG2MSI2
TMEM59ENSG00000116209.73247.424602144.734900.598403.516702.50700HepG2PABPC1
TMEM59ENSG00000116209.72084.156803652.39350-0.8094030.5910028.94400HepG2PCBP1
TMEM59ENSG00000116209.7980.035601251.31640-0.352504.143703.21690HepG2PRPF4
TMEM59ENSG00000116209.72271.730101346.179100.7548010.478809.03750HepG2PRPF8
TMEM59ENSG00000116209.72946.375903716.43200-0.335005.911705.17290HepG2PTBP1
TMEM59ENSG00000116209.73725.027202808.775200.407203.216502.58020HepG2PUF60
TMEM59ENSG00000116209.72892.799302199.032800.395508.537607.55640HepG2PUS1
TMEM59ENSG00000116209.73482.786204025.01940-0.208802.153201.59020HepG2QKI
TMEM59ENSG00000116209.72568.702301907.486100.429301.985701.37860HepG2RAVER1
TMEM59ENSG00000116209.74494.309502899.449300.6322017.2814016.21300HepG2RBM22
TMEM59ENSG00000116209.72156.847004136.04440-0.9393040.2995038.77760HepG2NELFE
TMEM59ENSG00000116209.72060.708003852.14080-0.9025038.0166036.24200HepG2RECQL
TMEM59ENSG00000116209.72738.406801827.927300.583007.815706.75830HepG2RPLP0
TMEM59ENSG00000116209.72616.807701873.772700.481802.863201.90450HepG2RPS10
TMEM59ENSG00000116209.71993.051801331.681800.581605.825304.72740HepG2RRP9
TMEM59ENSG00000116209.72657.949703869.31220-0.5418014.8695013.66550HepG2SF3B4
TMEM59ENSG00000116209.72332.613401303.572400.839405.531704.41650HepG2SNRNP70
TMEM59ENSG00000116209.74356.367803274.889800.4116011.2317010.40650HepG2SRFBP1
TMEM59ENSG00000116209.72722.439704038.71330-0.5690018.1200017.13270HepG2SRSF1
TMEM59ENSG00000116209.71744.769601260.482200.469003.291902.19000HepG2SRSF3
TMEM59ENSG00000116209.73898.161202773.196100.4911012.1236010.93950HepG2SRSF5
TMEM59ENSG00000116209.72168.520301667.046500.379305.927304.97090HepG2SRSF7
TMEM59ENSG00000116209.72686.301703153.93960-0.231503.755303.05030HepG2SUCLG1
TMEM59ENSG00000116209.71632.439501256.906400.377103.478602.43370HepG2SUPT6H
TMEM59ENSG00000116209.72502.261401736.861900.526605.282304.39590HepG2SUPV3L1
TMEM59ENSG00000116209.72511.338303630.12270-0.5316011.4995010.47970HepG2TAF15
TMEM59ENSG00000116209.72001.486301153.411700.7951012.4501011.07930HepG2TARDBP
TMEM59ENSG00000116209.71672.538901164.215300.522604.795803.53650HepG2TFIP11
TMEM59ENSG00000116209.72240.563201592.522800.492404.699403.89230HepG2U2AF1
TMEM59ENSG00000116209.72090.549301410.660100.5674013.7328012.40210HepG2UPF1
TMEM59ENSG00000116209.71746.596101449.997700.268402.957601.87970HepG2UTP18
TMEM59ENSG00000116209.7912.319601361.94430-0.5781010.459809.41430HepG2UTP3
TMEM59ENSG00000116209.72927.289402110.738100.471703.091101.92570HepG2XPO5
TMEM59ENSG00000116209.71905.305001234.914800.6255016.7075015.29220HepG2ZC3H8
TMEM59ENSG00000116209.72553.668101551.462900.7188021.0685019.90550HepG2ZNF622
TMEM59ENSG00000116209.73462.571302297.826000.5915017.5347016.22880K562AGGF1
TMEM59ENSG00000116209.73556.345802525.102200.494006.746405.04190K562AKAP8
TMEM59ENSG00000116209.74357.697102391.026200.8658015.2763013.52950K562AKAP8L
TMEM59ENSG00000116209.75516.081203619.227500.607909.511308.52720K562AQR
TMEM59ENSG00000116209.73403.257502508.826600.439805.037803.76440K562ATP5C1
TMEM59ENSG00000116209.71473.646101182.634100.317302.141001.38010K562BOP1
TMEM59ENSG00000116209.71506.134701257.486400.260201.993801.31930K562CPSF6
TMEM59ENSG00000116209.72026.217701481.825000.451303.298901.89310K562EEF2
TMEM59ENSG00000116209.72539.263802124.387200.257302.977102.23560K562EIF2S2
TMEM59ENSG00000116209.71466.883301821.95810-0.312703.535802.64310K562EIF3G
TMEM59ENSG00000116209.72388.530401452.551200.717406.646505.28940K562FIP1L1
TMEM59ENSG00000116209.71418.081701084.442500.386902.902301.96540K562FTO
TMEM59ENSG00000116209.72048.043101610.730100.346403.529101.99100K562FUS
TMEM59ENSG00000116209.71722.113102068.33450-0.264302.666202.07040K562FXR1
TMEM59ENSG00000116209.71578.583701200.595700.394803.660702.75190K562GPKOW
TMEM59ENSG00000116209.73645.130602830.842000.364604.072703.15760K562GRSF1
TMEM59ENSG00000116209.73101.309701969.081200.655304.653603.62730K562HSPD1
TMEM59ENSG00000116209.71935.955502643.65410-0.449503.508302.30130K562IGF2BP2
TMEM59ENSG00000116209.73906.376102537.356700.622405.680304.40240K562KIF1C
TMEM59ENSG00000116209.72036.535602779.23480-0.448605.647804.43630K562MAGOH
TMEM59ENSG00000116209.73426.428402428.971800.496302.439301.45150K562MAK16
TMEM59ENSG00000116209.73535.720802842.497200.314703.418102.38950K562MBNL1
TMEM59ENSG00000116209.73573.635801992.395200.842808.860106.92910K562NAA15
TMEM59ENSG00000116209.71983.389701723.288800.202702.831602.07740K562NSUN2
TMEM59ENSG00000116209.72999.827001958.226100.615202.889501.87180K562PABPN1
TMEM59ENSG00000116209.72679.679301874.237000.515705.062403.93710K562PCBP3
TMEM59ENSG00000116209.71969.309101437.597900.453905.964004.79240K562POLR2G
TMEM59ENSG00000116209.72621.246201649.210400.668406.141604.83770K562PPIG
TMEM59ENSG00000116209.72050.487801393.387400.557306.519605.36690K562PRPF8
TMEM59ENSG00000116209.72083.840102700.13650-0.373804.366803.55000K562PTBP1
TMEM59ENSG00000116209.75155.797904120.395600.323302.887702.05390K562PUF60
TMEM59ENSG00000116209.75713.195602370.997901.2687035.3596033.36910K562PUS1
TMEM59ENSG00000116209.74269.767502310.382500.8859029.2880027.27740K562RBM15
TMEM59ENSG00000116209.72070.638302589.57740-0.322602.799901.95440K562RBM22
TMEM59ENSG00000116209.72191.158902725.00630-0.314602.460201.43970K562NELFE
TMEM59ENSG00000116209.72057.495201424.888900.529904.055602.43880K562RRP9
TMEM59ENSG00000116209.72034.377301700.538800.258502.967702.12530K562SF3A3
TMEM59ENSG00000116209.71235.672101657.19900-0.423504.416703.03660K562SRSF4
TMEM59ENSG00000116209.71083.648201441.95610-0.412104.552903.49160K562SYNCRIP
TMEM59ENSG00000116209.72464.311101898.570400.376206.221304.29080K562TROVE2
TMEM59ENSG00000116209.72206.881901827.244600.272203.851403.01600K562UPF1
TMEM59ENSG00000116209.73923.115102404.191600.706304.157802.46560K562UTP18
TMEM59ENSG00000116209.75153.063704076.651900.337903.605102.59470K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for TMEM59 is not available on ENCORE database.





24 RBPs can affect the splicing of TMEM59 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SETMEM59ENSG00000116209.7chr1-5451293954513045545090455450919854518672545188650.238000.000150.03629includedK562FTO
SETMEM59ENSG00000116209.7chr1-545129395451304554509045545091985451867254518865-0.144000.000760.01669excludedK562SF3B4
SETMEM59ENSG00000116209.7chr1-5451432254514355545129395451304554519028545190850.858000.000000.00000includedHepG2U2AF1
SETMEM59ENSG00000116209.7chr1-545129395451304554509045545091985451867254518865-0.076000.003780.08509excludedK562AKAP8L
SETMEM59ENSG00000116209.7chr1-5451432254514355545129395451304554518672545190780.065000.011050.09867includedHepG2U2AF2
SETMEM59ENSG00000116209.7chr1-545113645451145954509045545091985451867254519111-0.092000.000870.01251excludedHepG2U2AF2
SETMEM59ENSG00000116209.7chr1-545113645451145954509057545091985451867254519078-0.134000.000000.00000excludedK562AQR
SETMEM59ENSG00000116209.7chr1-5451293954513045545090455450919854518672545188650.064000.000000.00060includedHepG2DDX3X
SETMEM59ENSG00000116209.7chr1-545113645451145954509045545091985451867254519078-0.076000.000000.00000excludedK562PUS1
SETMEM59ENSG00000116209.7chr1-5451293954513045545090455450919854518672545188650.063000.000050.00611includedHepG2NCBP2
SETMEM59ENSG00000116209.7chr1-5451293954513045545113645451145954519028545191770.080000.000040.03262includedHepG2UPF1
SETMEM59ENSG00000116209.7chr1-5451293954513045545090455450919854518672545191110.121000.000670.04444includedHepG2FTO
SETMEM59ENSG00000116209.7chr1-5451293954513045545090455450919854518672545188650.068000.000070.00544includedHepG2MATR3
SETMEM59ENSG00000116209.7chr1-545113645451145954509045545091985451867254519078-0.065000.001750.04742excludedHepG2SF3A3
SETMEM59ENSG00000116209.7chr1-5451293954513045545090455450919854518672545188650.056000.000370.03234includedHepG2IGF2BP3
SETMEM59ENSG00000116209.7chr1-545113645451145954509045545091985451867254519078-0.051000.000170.01149excludedHepG2PCBP1
SETMEM59ENSG00000116209.7chr1-545113645451145954509045545091985451867254519078-0.052000.000040.00266excludedK562UTP18
SETMEM59ENSG00000116209.7chr1-545129395451304554509045545091985451867254518865-0.142000.000000.00013excludedK562RBM15
SETMEM59ENSG00000116209.7chr1-545129395451304554509045545091985451867254518865-0.080000.004110.08006excludedK562AGGF1
A5SSTMEM59ENSG00000116209.7chr1-5451867254519078545188345451907854508997545091980.228000.006750.09216longerK562AQR
A5SSTMEM59ENSG00000116209.7chr1-545186725451886554518834545188655451293954513045-0.169000.000190.07219shorterK562TAF15
MXETMEM59ENSG00000116209.7chr1-54511364545114595451293954513045545090455450919854518672545191110.106000.000260.009781includedHepG2MATR3
MXETMEM59ENSG00000116209.7chr1-54511364545114595451293954513045545090455450919854518672545191110.119000.003400.056031includedHepG2FTO
MXETMEM59ENSG00000116209.7chr1-5451136454511459545129395451304554509045545091985451867254519111-0.103000.000510.063272includedHepG2FUS
MXETMEM59ENSG00000116209.7chr1-54511364545114595451293954513045545090455450919854518672545191110.099000.000730.030141includedHepG2PTBP1
MXETMEM59ENSG00000116209.7chr1-54511364545114595451293954513045545090455450919854518672545191110.106000.000840.022801includedHepG2DDX55
MXETMEM59ENSG00000116209.7chr1-5451136454511459545129395451304554509045545091985451867254519111-0.102000.003450.048872includedHepG2HNRNPUL1
MXETMEM59ENSG00000116209.7chr1-54511364545114005451293954513045545090455450919854518672545191110.151000.000230.021191includedHepG2SRSF7
MXETMEM59ENSG00000116209.7chr1-54511364545114005451293954513045545090455450919854518672545191110.100000.002150.063711includedHepG2SUPV3L1
MXETMEM59ENSG00000116209.7chr1-54511364545114595451293954513045545090455450919854518672545191110.093000.001170.042121includedHepG2NCBP2

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for TMEM59 is not avaliable on ENCORE database.