NUPL2

General Information

Gene Name : NUPL2
Gene ID : ENSG00000136243.16
Essential Gene : No

Functions

RNA export

Localization

Not Available

Domains (AlphaFold: NUPL2)

ZNF

Antibody Validation

Not Avaiable

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	NUPL2	ENSG00000136243.16	58.68	56.21	57.45	ENCSR000AEF
HepG2	NUPL2	ENSG00000136243.16	16.55	31.41	23.98	ENCSR985KAT
K562	NUPL2	ENSG00000136243.16	45.11	44.93	45.02	ENCSR000AEO

Assays

1 Released experiments are available on ENCORE database.

Assay Type	Exp_Name	ENCODE ID	Target label	Biosample	Status	Linked Antibody	Controls	Method	Note
RNA Bind-n-Seq	RBNS: NUPL2	ENCSR102MQN	NUPL2	cell-free sample	Released		ENCSR278BSO

eCLIP

No eCLIP experiment available

Antibody Validation

No Antibody Primary Validation image or Secondary image available

KD RNA-Seq

No KD RNA-Seq experiment available

RNA Bind-n-Seqn

GeneName	gene_aliases	Status	Project	Note
NUPL2	NUPL2		Released	ENCODE3

Localization Image in HepG2

No Localization Information available

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela

Summary
Proteins Bound to RBP RNA

RNA Targets

eCLIP assay for NUPL2 is not avaliable on ENCORE database.

The binding motifs of NUPL2

Proteins bound to RNA

NUPL2 RNA is bound by 20 proteins.

eCLIP assay for NUPL2 is not avaliable on ENCORE database.

20 proteins are bound to NUPL2 RNA:

Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr7	23240416	23240489	+	3'-UTR	4.10879	5.97140	K562	PUM2
chr7	23240036	23240138	+	3'-UTR,CDS	3.22107	3.63681	K562	RBM15
chr7	23236276	23236344	+	3'-UTR,CDS,intron-Proximal	4.17688	6.44495	HepG2	U2AF2
chr7	23235434	23235515	+	3'-UTR,CDS,intron-Proximal	3.59192	7.74495	HepG2	U2AF2
chr7	23239065	23239160	+	3'-UTR,CDS,intron-Proximal	4.74789	5.47569	HepG2	U2AF2
chr7	23240161	23240271	+	3'-UTR,CDS	4.08221	3.31904	K562	IGF2BP1
chr7	23239074	23239164	+	3'-UTR,CDS,intron-Proximal	3.73440	5.15500	HepG2	BCLAF1
chr7	23239856	23239958	+	3'-UTR,CDS	4.15197	3.73331	K562	RBM15
chr7	23226668	23226780	+	5'-UTR,CDS,intron-Distal,intron-Proximal	4.49134	9.30195	HepG2	BCLAF1
chr7	23226670	23226771	+	5'-UTR,CDS,intron-Distal,intron-Proximal	3.17368	4.09741	HepG2	PPIG
chr7	23226668	23226779	+	5'-UTR,CDS,intron-Distal,intron-Proximal	3.85787	8.54758	K562	ZNF622
chr7	23226722	23226806	+	5'-UTR,CDS,intron-Distal,intron-Proximal	4.20636	7.80986	K562	PRPF8
chr7	23226668	23226777	+	5'-UTR,CDS,intron-Distal,intron-Proximal	4.03855	4.47351	K562	GRWD1
chr7	23226675	23226790	+	5'-UTR,CDS,intron-Distal,intron-Proximal	3.74278	4.06757	K562	UCHL5
chr7	23221686	23221827	+	5'-UTR,CDS,intron-Distal,intron-Proximal	3.08679	4.88807	HepG2	NCBP2
chr7	23226698	23226788	+	5'-UTR,CDS,intron-Distal,intron-Proximal	4.45055	4.75655	HepG2	PRPF8
chr7	23221762	23221816	+	CDS,intron-Distal	3.83178	3.01428	K562	UCHL5
chr7	23221767	23221831	+	CDS,intron-Distal,intron-Proximal	3.30841	3.64266	HepG2	PPIG
chr7	23224813	23224918	+	CDS,intron-Distal,intron-Proximal	4.20924	4.88315	K562	GRWD1
chr7	23224839	23224925	+	CDS,intron-Distal,intron-Proximal	3.84659	4.46864	HepG2	BCLAF1
chr7	23224730	23224918	+	CDS,intron-Distal,intron-Proximal	3.20415	8.48432	K562	ZNF622
chr7	23221719	23221824	+	CDS,intron-Distal	3.11594	5.48399	K562	DDX3X
chr7	23224860	23224915	+	CDS,intron-Distal	4.45225	5.40333	K562	RBM15
chr7	23224697	23224790	+	CDS,intron-Distal	3.38055	4.47973	K562	YBX3
chr7	23224807	23224918	+	CDS,intron-Distal,intron-Proximal	3.19472	3.80299	HepG2	GRWD1
chr7	23228350	23228387	+	intron-Distal	4.94579	6.40061	K562	ILF3
chr7	23230248	23230301	+	intron-Distal	3.96622	3.71397	K562	KHSRP
chr7	23236687	23236790	+	intron-Distal,intron-Proximal	4.18960	3.92684	K562	KHSRP
chr7	23233602	23233644	+	intron-Distal	5.34058	6.79336	K562	DGCR8
chr7	23236043	23236145	+	intron-Distal	3.73813	11.85499	HepG2	QKI
chr7	23235038	23235108	+	intron-Distal	3.88126	3.26999	K562	KHSRP
chr7	23228326	23228350	+	intron-Distal	4.23574	7.07933	K562	ILF3
chr7	23230066	23230163	+	intron-Distal	4.74716	6.80456	K562	KHSRP
chr7	23228319	23228412	+	intron-Distal	3.85663	3.24590	HepG2	ILF3
chr7	23235200	23235285	+	intron-Distal	4.80249	8.09131	HepG2	CSTF2
chr7	23233603	23233674	+	intron-Distal	4.54059	5.89204	HepG2	DGCR8
chr7	23221839	23221951	+	intron-Distal,intron-Proximal	5.53551	5.35117	HepG2	PRPF8
chr7	23232274	23232393	+	intron-Distal	5.37074	7.27881	HepG2	KHSRP
chr7	23229849	23229948	+	intron-Distal	3.15662	3.81590	K562	HNRNPL
chr7	23232268	23232389	+	intron-Distal	3.98409	4.12078	HepG2	FUS
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

eCLIP assay for NUPL2 is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout assay for NUPL2 is not available on ENCORE database.
39 RBPs can affect the levels of NUPL2.

The Knockdown/knockout RNA-Seq assay for NUPL2 is not available on ENCORE database.

39 RBPs can affect the gene expression of NUPL2 :

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
NUPL2	ENSG00000136243.12	394.49510	307.91300	0.35740	2.15020	1.46280	HepG2	AKAP8L
NUPL2	ENSG00000136243.12	348.68620	534.11300	-0.61520	3.57640	2.81260	HepG2	AUH
NUPL2	ENSG00000136243.12	652.37850	331.10260	0.97830	11.52460	10.41550	HepG2	BOP1
NUPL2	ENSG00000136243.12	448.66000	315.72030	0.50690	2.89110	2.10070	HepG2	CIRBP
NUPL2	ENSG00000136243.12	397.44270	306.40930	0.37520	2.47330	1.83750	HepG2	CKAP4
NUPL2	ENSG00000136243.12	356.03360	242.29580	0.55510	3.17820	2.19730	HepG2	DDX24
NUPL2	ENSG00000136243.12	551.02290	384.74270	0.51810	3.11860	2.45890	HepG2	DDX3X
NUPL2	ENSG00000136243.12	376.12450	293.20310	0.35920	1.99210	1.40300	HepG2	DKC1
NUPL2	ENSG00000136243.12	212.01550	317.72120	-0.58360	2.78530	2.18980	HepG2	EIF2S1
NUPL2	ENSG00000136243.12	627.51060	341.84090	0.87620	6.17320	5.17550	HepG2	EIF4B
NUPL2	ENSG00000136243.12	496.84540	348.82700	0.51020	3.03710	2.10390	HepG2	G3BP2
NUPL2	ENSG00000136243.12	350.36110	456.74480	-0.38250	2.80260	2.12540	HepG2	HNRNPL
NUPL2	ENSG00000136243.12	348.41490	253.53870	0.45850	2.59160	1.66990	HepG2	HNRNPM
NUPL2	ENSG00000136243.12	442.91420	334.05450	0.40680	2.01960	1.43390	HepG2	IGF2BP2
NUPL2	ENSG00000136243.12	473.87330	354.33840	0.41930	2.07810	1.50640	HepG2	MAGOH
NUPL2	ENSG00000136243.12	497.10760	356.33370	0.48020	2.44690	1.85080	HepG2	MATR3
NUPL2	ENSG00000136243.12	444.60600	323.07940	0.46050	3.43240	2.77250	HepG2	PCBP1
NUPL2	ENSG00000136243.12	372.99220	503.44630	-0.43270	2.91660	2.22830	HepG2	PUM2
NUPL2	ENSG00000136243.12	741.01620	512.50650	0.53180	4.81140	4.17560	HepG2	RBM22
NUPL2	ENSG00000136243.12	213.93120	323.12930	-0.59500	3.52230	2.76900	HepG2	RBM25
NUPL2	ENSG00000136243.12	446.78980	309.36650	0.53020	2.68600	1.39350	HepG2	SART3
NUPL2	ENSG00000136243.12	546.76630	409.71510	0.41620	1.94860	1.38020	HepG2	SF3A3
NUPL2	ENSG00000136243.12	432.34830	325.53120	0.40930	2.16010	1.53170	HepG2	SF3B1
NUPL2	ENSG00000136243.12	563.95210	342.27000	0.72030	7.88710	6.96990	HepG2	SF3B4
NUPL2	ENSG00000136243.12	399.91000	578.88250	-0.53360	2.93050	2.41940	HepG2	SRFBP1
NUPL2	ENSG00000136243.12	467.73160	357.25220	0.38860	2.39610	1.94770	HepG2	SRSF1
NUPL2	ENSG00000136243.12	312.09990	393.41130	-0.33400	2.00810	1.40470	HepG2	SRSF7
NUPL2	ENSG00000136243.12	508.98320	321.10240	0.66450	6.14780	5.36800	HepG2	TAF15
NUPL2	ENSG00000136243.12	426.79650	314.32740	0.44120	2.29230	1.71590	HepG2	U2AF1
NUPL2	ENSG00000136243.12	308.82920	191.90530	0.68630	4.21150	3.27440	HepG2	UCHL5
NUPL2	ENSG00000136243.12	549.59210	350.80500	0.64760	6.83320	5.96330	HepG2	UTP3
NUPL2	ENSG00000136243.12	422.91730	592.89980	-0.48740	4.48860	3.79670	K562	AGGF1
NUPL2	ENSG00000136243.12	482.62520	614.01000	-0.34740	2.78000	1.81760	K562	BCLAF1
NUPL2	ENSG00000136243.12	257.99830	379.12530	-0.55530	3.67490	2.45290	K562	DDX3X
NUPL2	ENSG00000136243.12	597.64770	396.08630	0.59340	4.93330	3.83380	K562	EIF4A3
NUPL2	ENSG00000136243.12	735.63040	411.91210	0.83650	12.23660	11.05750	K562	FXR1
NUPL2	ENSG00000136243.12	613.36170	804.42310	-0.39120	2.40740	1.42910	K562	HNRNPL
NUPL2	ENSG00000136243.12	527.15470	660.08040	-0.32440	2.85250	2.09610	K562	NSUN2
NUPL2	ENSG00000136243.12	1607.11850	1304.15320	0.30130	3.39870	2.21100	K562	PUM1
NUPL2	ENSG00000136243.12	282.45780	408.20960	-0.53130	3.00780	1.61170	K562	RBM25
NUPL2	ENSG00000136243.12	471.92220	591.96250	-0.32700	2.39740	1.31120	K562	SRSF7
NUPL2	ENSG00000136243.12	319.11440	433.48520	-0.44190	2.42770	1.55150	K562	TRIM56
NUPL2	ENSG00000136243.12	570.42050	699.89460	-0.29510	1.96280	1.35040	K562	UPF1
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

The Knockdown/knockout RNA-Seq assay for NUPL2 is not available on ENCORE database.

25 RBPs can affect the splicing of NUPL2 :

Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	2ndExonStart	2ndExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	p-value	FDR	is_included	Cell Line	Affected by RBP
SE	NUPL2	ENSG00000136243.12	chr7	+	23236791	23236866			23236298	23236385	23239076	23239161	0.19100	0.00002	0.00342	included	HepG2	G3BP1
SE	NUPL2	ENSG00000136243.12	chr7	+	23236791	23236866			23236298	23236385	23239076	23239161	0.16700	0.00004	0.01173	included	K562	FTO
SE	NUPL2	ENSG00000136243.12	chr7	+	23236791	23236866			23236298	23236385	23239076	23239161	0.25800	0.00000	0.00058	included	K562	XRN2
SE	NUPL2	ENSG00000136243.12	chr7	+	23236298	23236385			23226670	23226765	23239076	23239161	-0.18800	0.00034	0.01338	excluded	K562	AKAP8L
SE	NUPL2	ENSG00000136243.12	chr7	+	23236791	23236866			23236298	23236385	23239076	23239161	0.25700	0.00001	0.01738	included	K562	TROVE2
SE	NUPL2	ENSG00000136243.12	chr7	+	23236791	23236866			23236298	23236385	23239076	23239161	0.25900	0.00000	0.00036	included	K562	XRCC6
SE	NUPL2	ENSG00000136243.12	chr7	+	23236791	23236866			23236298	23236385	23239076	23239161	0.28300	0.00000	0.00000	included	K562	FMR1
SE	NUPL2	ENSG00000136243.12	chr7	+	23236791	23236866			23236298	23236385	23239076	23239161	0.27100	0.00000	0.00009	included	HepG2	HNRNPK
SE	NUPL2	ENSG00000136243.12	chr7	+	23236791	23236866			23236298	23236385	23239076	23239161	0.18500	0.00002	0.00740	included	K562	METAP2
SE	NUPL2	ENSG00000136243.12	chr7	+	23235457	23235534			23226670	23226765	23236298	23236385	-0.17600	0.00001	0.00017	excluded	K562	AQR
SE	NUPL2	ENSG00000136243.12	chr7	+	23224698	23224917			23221445	23221825	23226670	23227011	-0.05700	0.01120	0.08886	excluded	K562	AQR
SE	NUPL2	ENSG00000136243.12	chr7	+	23236298	23236385			23226670	23226765	23239076	23239161	-0.30600	0.00000	0.00008	excluded	K562	PUS1
SE	NUPL2	ENSG00000136243.12	chr7	+	23236791	23236866			23236298	23236385	23239076	23239161	0.18800	0.00001	0.00340	included	K562	MTPAP
SE	NUPL2	ENSG00000136243.12	chr7	+	23236791	23236866			23236298	23236385	23239076	23239161	0.20000	0.00013	0.06889	included	HepG2	UPF1
SE	NUPL2	ENSG00000136243.12	chr7	+	23236791	23236866			23236298	23236385	23239076	23239161	0.22000	0.00002	0.01240	included	K562	UCHL5
SE	NUPL2	ENSG00000136243.12	chr7	+	23236791	23236866			23236298	23236385	23239076	23239161	0.13500	0.00025	0.01443	included	HepG2	MATR3
SE	NUPL2	ENSG00000136243.12	chr7	+	23224698	23224917			23221445	23221825	23226670	23226765	-0.14000	0.00034	0.02871	excluded	K562	HNRNPL
SE	NUPL2	ENSG00000136243.12	chr7	+	23236791	23236866			23236298	23236385	23239076	23239161	0.14500	0.00035	0.03157	included	HepG2	IGF2BP3
SE	NUPL2	ENSG00000136243.12	chr7	+	23236791	23236866			23236298	23236385	23239076	23239161	0.08100	0.00007	0.04979	included	K562	PUM2
SE	NUPL2	ENSG00000136243.12	chr7	+	23236791	23236866			23236298	23236385	23239076	23239161	0.11100	0.00000	0.00069	included	K562	EIF4G2
SE	NUPL2	ENSG00000136243.12	chr7	+	23235457	23235534			23226670	23226765	23236298	23236385	0.18700	0.00007	0.00438	included	K562	TARDBP
SE	NUPL2	ENSG00000136243.12	chr7	+	23236791	23236866			23236298	23236385	23239076	23239161	0.10300	0.00038	0.01764	included	K562	HNRNPU
SE	NUPL2	ENSG00000136243.12	chr7	+	23236791	23236866			23236298	23236385	23239076	23239161	0.12300	0.00096	0.02664	included	K562	RBM15
SE	NUPL2	ENSG00000136243.12	chr7	+	23236791	23236866			23236298	23236385	23239076	23239161	0.29800	0.00017	0.04447	included	HepG2	FUS
SE	NUPL2	ENSG00000136243.12	chr7	+	23236791	23236866			23236298	23236385	23239076	23239161	0.28300	0.00014	0.02978	included	HepG2	KHSRP
MXE	NUPL2	ENSG00000136243.12	chr7	+	23226670	23226765	23235457	23235534	23224688	23224917	23236298	23236385	-0.22300	0.00106	0.00852	2included	HepG2	U2AF2

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

NUPL2

General Information

Functions

Localization

Domains (AlphaFold: NUPL2)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

eCLIP assay for NUPL2 is not avaliable on ENCORE database.

20 proteins are bound to NUPL2 RNA:

eCLIP assay for NUPL2 is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout RNA-Seq assay for NUPL2 is not available on ENCORE database.

39 RBPs can affect the gene expression of NUPL2 :

The Knockdown/knockout RNA-Seq assay for NUPL2 is not available on ENCORE database.

25 RBPs can affect the splicing of NUPL2 :

The Knockdown/knockout RNA-Seq assay for NUPL2 is not avaliable on ENCORE database.