POLA2

General Information

Gene Name       : POLA2
Gene ID             : ENSG00000014138.8
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: POLA2)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878POLA2ENSG00000014138.892.2182.1187.16ENCSR000AEF
HepG2POLA2ENSG00000014138.817.8919.0518.47ENCSR985KAT
K562POLA2ENSG00000014138.866.9776.0471.50ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for POLA2 is not avaliable on ENCORE database.



Proteins bound to RNA
  • POLA2 RNA is bound by 16 proteins.  







eCLIP assay for POLA2 is not avaliable on ENCORE database.





16 proteins are bound to POLA2 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr116504843665048509+3'-UTR,CDS,intron-Proximal4.2789210.72926K562BUD13
chr116504844065048499+3'-UTR,CDS,intron-Proximal5.531737.00086K562DDX24
chr116504995365050079+3'-UTR,CDS,intron-Proximal3.079608.40422K562PRPF8
chr116505733965057392+3'-UTR,CDS,intron-Proximal4.353347.15298K562AQR
chr116504996365050027+3'-UTR,CDS,intron-Proximal5.201527.79098HepG2PRPF8
chr116504994965049987+3'-UTR,CDS,intron-Proximal3.313733.59112HepG2PPIG
chr116504706965047134+3'-UTR,CDS,intron-Proximal3.530795.04653K562SF3B4
chr116504915265049201+3'-UTR,CDS3.530754.71060K562BUD13
chr116504840865048497+3'-UTR,CDS,intron-Proximal3.679578.47924K562SF3B4
chr116504709165047114+3'-UTR,CDS,intron-Proximal3.759226.79537K562AQR
chr116504705265047099+3'-UTR,CDS,intron-Proximal3.313736.54857HepG2PPIG
chr116505531065055353+3'-UTR,CDS,intron-Proximal3.768384.49024K562AQR
chr116504995865049995+3'-UTR,CDS,intron-Proximal4.144363.53690K562ZNF622
chr116506342665063471+3'-UTR,CDS,intron-Proximal4.127123.49905HepG2PPIG
chr116506212265062156+3'-UTR,CDS,intron-Proximal6.1802128.25500K562AQR
chr116504846065048515+3'-UTR,CDS,intron-Proximal3.186455.14343HepG2PPIG
chr116504843865048489+3'-UTR,CDS,intron-Proximal4.275638.29266K562AQR
chr116505518565055229+3'-UTR,CDS,intron-Proximal4.525915.24155K562BUD13
chr116504996065050005+3'-UTR,CDS,intron-Proximal3.407394.17944K562BUD13
chr116504614065046225+5'-UTR,CDS,intron-Proximal4.1093811.37858K562SF3B4
chr116504631465046367+5'-UTR,CDS4.752895.27053HepG2PPIG
chr116502951565029560+5'-UTR4.024996.42503K562DDX3X
chr116504340165043494+5'-UTR,CDS,intron-Proximal4.881365.03746HepG2BCLAF1
chr116504335065043405+5'-UTR,CDS,intron-Proximal3.208826.76881K562BUD13
chr116503495065035008+5'-UTR,CDS3.100293.87559K562YBX3
chr116504346765043530+5'-UTR,CDS,intron-Proximal3.704434.93376K562PRPF8
chr116507152865071554+intron-Distal4.347693.79905K562AGGF1
chr116505471565054930+intron-Distal4.578064.76505K562HNRNPK
chr116504713765047266+intron-Distal,intron-Proximal3.704439.49597K562PRPF8
chr116506892465069046+intron-Distal4.130053.59342K562CSTF2T
chr116507190365071980+intron-Distal4.058934.77135HepG2HNRNPL
chr116507193265072002+intron-Distal3.294413.94360HepG2GTF2F1
chr116507212365072192+intron-Distal4.369184.42836K562AKAP8L
chr116507163565071748+intron-Distal6.3074216.62195K562AGGF1
chr116507158765071635+intron-Distal4.172448.06399K562AGGF1
chr116507190865071992+intron-Distal6.8994425.93951K562AGGF1
chr116507213965072227+intron-Distal4.785985.71957HepG2AGGF1
chr116507192365071985+intron-Distal4.728385.63094K562GTF2F1
chr116507211365072223+intron-Distal5.7435512.11710K562GTF2F1
chr116506307065063114+intron-Proximal3.370154.41130K562AQR
chr116506215665062178+intron-Proximal6.1672127.71304K562AQR
chr116504711465047175+intron-Proximal4.7683810.08262K562AQR
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for POLA2 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for POLA2 is not available on ENCORE database.

  • 107 RBPs can affect the levels of POLA2.  








The Knockdown/knockout RNA-Seq assay for POLA2 is not available on ENCORE database.





107 RBPs can affect the gene expression of POLA2 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
POLA2ENSG00000014138.4291.88860383.38450-0.393402.474801.74480HepG2AKAP8L
POLA2ENSG00000014138.486.94660198.25710-1.189206.511305.33220HepG2ASCC1
POLA2ENSG00000014138.4316.99180510.23410-0.686706.996005.98460HepG2AUH
POLA2ENSG00000014138.4172.87570314.50050-0.863304.657103.51530HepG2BCLAF1
POLA2ENSG00000014138.4121.41600291.44850-1.2633010.024808.97840HepG2BOP1
POLA2ENSG00000014138.4140.91870346.29420-1.2971012.4781011.03490HepG2CALR
POLA2ENSG00000014138.4108.10120188.35870-0.801103.374902.52570HepG2CIRBP
POLA2ENSG00000014138.4129.91830381.51970-1.5542023.7431022.22600HepG2CKAP4
POLA2ENSG00000014138.4132.55050267.56840-1.013406.279105.27350HepG2CPSF6
POLA2ENSG00000014138.4341.63690442.22090-0.372302.235501.64680HepG2CELF1
POLA2ENSG00000014138.4275.50850352.89840-0.357202.270501.50970HepG2DDX19B
POLA2ENSG00000014138.4158.65610306.47310-0.949906.992205.96520HepG2DDX21
POLA2ENSG00000014138.4175.91310299.93820-0.769804.999703.76550HepG2DDX24
POLA2ENSG00000014138.477.34940229.52580-1.5692010.969109.80030HepG2DDX3X
POLA2ENSG00000014138.4210.57230355.84460-0.756903.923103.01750HepG2DDX55
POLA2ENSG00000014138.4132.89450303.84270-1.193006.275404.83180HepG2DDX59
POLA2ENSG00000014138.4214.61360303.18690-0.498502.425001.47520HepG2DDX5
POLA2ENSG00000014138.490.33650197.17970-1.126105.512104.66610HepG2DDX6
POLA2ENSG00000014138.4277.77750365.04630-0.394102.251801.63060HepG2DKC1
POLA2ENSG00000014138.4123.91890282.24280-1.187507.958306.13880HepG2AGO1
POLA2ENSG00000014138.464.61850189.54140-1.552509.041408.00670HepG2EIF2S1
POLA2ENSG00000014138.4144.17310217.81090-0.595302.436001.58290HepG2EIF3D
POLA2ENSG00000014138.4139.76060209.45970-0.583702.149901.58370HepG2EIF4A3
POLA2ENSG00000014138.4130.15790203.94960-0.647902.136301.52900HepG2EIF4B
POLA2ENSG00000014138.4292.86310469.10120-0.679706.365105.18690HepG2EIF4G1
POLA2ENSG00000014138.4318.03750449.36290-0.498702.890702.05970HepG2EIF4G2
POLA2ENSG00000014138.4273.38670585.80870-1.0995017.1766015.88720HepG2ETF1
POLA2ENSG00000014138.4251.62520372.88830-0.567503.654802.69550HepG2EWSR1
POLA2ENSG00000014138.4114.12700268.02110-1.231704.501803.21470HepG2FTO
POLA2ENSG00000014138.4376.61450211.353900.833305.573404.61370HepG2FXR1
POLA2ENSG00000014138.4118.85430303.31760-1.351609.972908.81000HepG2GPKOW
POLA2ENSG00000014138.4272.30680364.29930-0.419902.813801.82940HepG2HDGF
POLA2ENSG00000014138.4213.65950380.69110-0.833304.002702.31240HepG2HLTF
POLA2ENSG00000014138.4280.51420436.97760-0.639505.387704.15740HepG2HNRNPA2B1
POLA2ENSG00000014138.4299.31810400.69280-0.420803.001902.25760HepG2HNRNPF
POLA2ENSG00000014138.4125.89360289.46080-1.201208.447107.41180HepG2HNRNPLL
POLA2ENSG00000014138.4286.84210394.56470-0.460002.960602.21390HepG2IGF2BP1
POLA2ENSG00000014138.470.98720199.27960-1.489209.104007.95770HepG2IGF2BP2
POLA2ENSG00000014138.4242.44690348.81420-0.524803.925402.71520HepG2KIF1C
POLA2ENSG00000014138.4221.38320363.84490-0.716802.390301.62240HepG2LARP4
POLA2ENSG00000014138.4186.07890295.19520-0.665802.422601.52080HepG2MTPAP
POLA2ENSG00000014138.4168.71860326.72450-0.953504.551703.12840HepG2NONO
POLA2ENSG00000014138.4124.74440256.65670-1.040905.984704.91010HepG2NSUN2
POLA2ENSG00000014138.432.5141088.21830-1.440004.405503.27010HepG2PABPC1
POLA2ENSG00000014138.484.40760193.78860-1.199006.747905.62770HepG2PABPC4
POLA2ENSG00000014138.4108.21920375.97360-1.7967017.0029014.76950HepG2PCBP2
POLA2ENSG00000014138.4281.37350375.91560-0.417902.727301.95810HepG2PRPF4
POLA2ENSG00000014138.479.08350274.54170-1.7956014.8181013.16370HepG2PRPF8
POLA2ENSG00000014138.4279.59370194.849200.520902.671402.13250HepG2PTBP1
POLA2ENSG00000014138.4218.01680450.06490-1.0457010.482009.42190HepG2PUF60
POLA2ENSG00000014138.4300.81650477.41950-0.666405.484004.55540HepG2PUM2
POLA2ENSG00000014138.4208.59130362.81620-0.798603.479002.69020HepG2RAVER1
POLA2ENSG00000014138.4251.19210366.68330-0.545703.653902.68350HepG2RBM15
POLA2ENSG00000014138.4156.35450489.62940-1.6469025.0864023.84110HepG2RBM22
POLA2ENSG00000014138.4130.67410191.53010-0.551602.220201.61060HepG2RBM25
POLA2ENSG00000014138.4380.28850216.855800.810306.654805.87760HepG2NELFE
POLA2ENSG00000014138.4319.77540201.958300.662904.392503.63950HepG2RECQL
POLA2ENSG00000014138.491.27610431.69450-2.2417033.5745031.79550HepG2RPLP0
POLA2ENSG00000014138.4100.87680356.40890-1.8209016.1476014.09100HepG2RPS10
POLA2ENSG00000014138.483.27000211.96840-1.348009.484508.42760HepG2RPS19
POLA2ENSG00000014138.4197.27190346.31730-0.811905.707804.58290HepG2RPS2
POLA2ENSG00000014138.457.66620271.58210-2.2356019.3430017.61410HepG2RRP9
POLA2ENSG00000014138.4211.63590383.36760-0.857105.298104.34760HepG2SF3A3
POLA2ENSG00000014138.4118.13900286.51360-1.278109.653208.40910HepG2SF3B1
POLA2ENSG00000014138.4294.60240431.56780-0.550804.547503.68280HepG2SLBP
POLA2ENSG00000014138.4183.15910354.00370-0.950703.722101.86760HepG2SLTM
POLA2ENSG00000014138.4165.00680318.79500-0.950104.712903.68130HepG2SNRNP70
POLA2ENSG00000014138.4183.32690553.02150-1.5929029.4979028.31150HepG2SRFBP1
POLA2ENSG00000014138.4170.69350308.27670-0.852804.407803.11600HepG2SRSF3
POLA2ENSG00000014138.4294.35700444.38860-0.594304.931204.13340HepG2SRSF5
POLA2ENSG00000014138.4137.66500393.67900-1.5159021.7610020.15690HepG2SRSF7
POLA2ENSG00000014138.4125.26790172.26860-0.459601.846201.37880HepG2SRSF9
POLA2ENSG00000014138.4347.95040480.15900-0.464603.723103.14780HepG2SSB
POLA2ENSG00000014138.4150.49550339.06230-1.171806.707904.87620HepG2SUB1
POLA2ENSG00000014138.4397.60230505.37940-0.346002.342601.76150HepG2SUCLG1
POLA2ENSG00000014138.481.77480141.59530-0.792002.680001.37730HepG2SUGP2
POLA2ENSG00000014138.483.72090354.24830-2.0811020.7449019.20000HepG2SUPV3L1
POLA2ENSG00000014138.497.24220282.11380-1.5366012.8365011.45140HepG2TARDBP
POLA2ENSG00000014138.4106.01270237.44670-1.163407.249305.76630HepG2TFIP11
POLA2ENSG00000014138.4141.98100300.87240-1.083504.740504.12180HepG2TIAL1
POLA2ENSG00000014138.4142.17210303.45570-1.093804.570603.88260HepG2TRIM56
POLA2ENSG00000014138.489.44670309.18150-1.7894016.5935015.00440HepG2U2AF1
POLA2ENSG00000014138.447.92800247.29610-2.367308.879707.01240HepG2U2AF2
POLA2ENSG00000014138.4172.07110339.98730-0.982507.533606.47350HepG2UPF1
POLA2ENSG00000014138.4241.23730328.24620-0.444302.537401.95870HepG2UTP3
POLA2ENSG00000014138.4254.82330399.00880-0.646903.345402.17630HepG2XRCC6
POLA2ENSG00000014138.4118.82960373.92260-1.6538023.8121022.60140HepG2ZNF622
POLA2ENSG00000014138.4167.65440362.49680-1.112508.222105.89140HepG2ZRANB2
POLA2ENSG00000014138.41275.205001666.14320-0.385805.719604.95060K562AGGF1
POLA2ENSG00000014138.41423.349901733.67450-0.284502.244501.65340K562AKAP8L
POLA2ENSG00000014138.41010.522002138.37950-1.0814020.9938019.55040K562AQR
POLA2ENSG00000014138.41483.998501852.96230-0.320304.182703.40330K562DDX47
POLA2ENSG00000014138.41421.594401865.70250-0.392205.594704.29570K562DKC1
POLA2ENSG00000014138.4699.434801194.39530-0.772009.578207.78350K562EFTUD2
POLA2ENSG00000014138.4530.204401003.07140-0.9198013.3252011.46640K562EIF4A3
POLA2ENSG00000014138.4923.956801207.84420-0.386503.044202.14360K562FMR1
POLA2ENSG00000014138.4759.318701023.81120-0.431203.042102.07870K562FTO
POLA2ENSG00000014138.4845.926201133.21770-0.421803.634202.72840K562GPKOW
POLA2ENSG00000014138.41656.017102261.38760-0.449505.423704.36130K562GRSF1
POLA2ENSG00000014138.41561.608501246.850500.324602.815802.21380K562HNRNPC
POLA2ENSG00000014138.4679.662501074.95720-0.661406.556804.59250K562HNRNPK
POLA2ENSG00000014138.41445.298301839.94270-0.348303.317302.40490K562KIF1C
POLA2ENSG00000014138.4564.39150967.76200-0.778006.377204.89450K562KRR1
POLA2ENSG00000014138.4888.424001131.30220-0.348702.878702.02030K562MAGOH
POLA2ENSG00000014138.41046.490501444.73730-0.465202.996002.07130K562NAA15
POLA2ENSG00000014138.4696.816401047.97310-0.588802.388801.48300K562PABPN1
POLA2ENSG00000014138.4683.520101006.47870-0.558305.568104.17060K562PCBP2
POLA2ENSG00000014138.42473.981601910.609500.372702.835201.99280K562PCBP3
POLA2ENSG00000014138.41906.531401465.489100.379503.902902.94500K562POLR2G
POLA2ENSG00000014138.4700.969301162.28440-0.729508.200906.90690K562PRPF8
POLA2ENSG00000014138.41106.878801719.49440-0.635507.128406.30310K562PUS1
POLA2ENSG00000014138.41334.356801675.25150-0.328203.638702.97210K562RBM15
POLA2ENSG00000014138.4773.516001053.67510-0.445903.884502.87730K562RBM22
POLA2ENSG00000014138.4827.308801183.90920-0.517103.984303.00160K562RPS19
POLA2ENSG00000014138.4753.736101077.91840-0.516103.805602.65620K562SF3B1
POLA2ENSG00000014138.4686.64330996.60750-0.537506.328205.00050K562SF3B4
POLA2ENSG00000014138.4678.639101100.62530-0.697602.912201.64070K562SNRNP200
POLA2ENSG00000014138.4766.362001077.61650-0.491705.100404.14380K562SRSF1
POLA2ENSG00000014138.4629.927301125.32770-0.837109.204607.28720K562SUPV3L1
POLA2ENSG00000014138.4492.38840929.01480-0.9159010.012207.72780K562U2AF1
POLA2ENSG00000014138.4562.06180959.51530-0.7716011.460109.81550K562U2AF2
POLA2ENSG00000014138.41339.358101553.46500-0.213902.315601.53600K562WDR43
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for POLA2 is not available on ENCORE database.





4 RBPs can affect the splicing of POLA2 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEPOLA2ENSG00000014138.4chr11+6506247965062682650620166506212365063010650630700.279000.002400.02928includedHepG2U2AF2
SEPOLA2ENSG00000014138.4chr11+650339776503417765029402650298426503494765035039-0.053000.012700.09805excludedK562AQR
SEPOLA2ENSG00000014138.4chr11+6506247965062682650620166506212365063010650630700.128000.000000.00000includedK562U2AF1
SEPOLA2ENSG00000014138.4chr11+6506247965062682650620166506212365063010650630700.116000.000000.00000includedK562U2AF2
SEPOLA2ENSG00000014138.4chr11+6504720265047258650470086504709765048462650486180.243000.000000.00004includedK562HNRNPK
SEPOLA2ENSG00000014138.4chr11+6506247965062682650620166506212365063010650630700.139000.000000.00010includedK562HNRNPK

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for POLA2 is not avaliable on ENCORE database.