SLTM

General Information

Gene Name : SLTM
Gene ID : ENSG00000137776.16
Essential Gene : Yes

Functions

Novel RBP

Localization(RBPImage: SLTM)

Nuclei
Nucleoplasm
Mutually Exclusive from Nucleolus
Cytoplasm
Cytoskeleton
Microtubule
Mitotic-Apparatus (Spindle; Centrosomes)

Domains (AlphaFold: SLTM)

RRM

Antibody Validation

Bethyl Labs: A302-834A

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	SLTM	ENSG00000137776.16	95.69	87.49	91.59	ENCSR000AEF
HepG2	SLTM	ENSG00000137776.16	74.51	61.91	68.21	ENCSR985KAT
K562	SLTM	ENSG00000137776.16	77.66	88.91	83.28	ENCSR000AEO

Assays

4 Released experiments are available on ENCORE database.

Assay Type	Exp_Name	ENCODE ID	Target label	Biosample	Status	Linked Antibody	Controls	Method	Note
eCLIP	eCLIP: 256	ENCSR000SSH	SLTM	K562	Released	ENCAB526HXQ	ENCSR820GBM
eCLIP	eCLIP: 227	ENCSR351PVI	SLTM	HepG2	Released	ENCAB526HXQ	ENCSR670UPZ
knockdown followed by RNA-seq	SLTM-BGKLV13-K562	ENCSR234YMW	SLTM	K562	Released		ENCSR084SCN	shRNA	KD% = 59.3,58.5
knockdown followed by RNA-seq	SLTM-BGHLV14-HepG2	ENCSR185JGT	SLTM	HepG2	Released		ENCSR491FOC	shRNA	KD% = 86.3,69.3

eCLIP

RBP	Exp_UID	Cell_Line	ENCODE_ACCESSION	Control_ENCODE_ACCESSION	ENCODE_Antibody_ID	Antibody	Lot_num	Status	Project
SLTM	256	K562	ENCSR000SSH	ENCSR820GBM	ENCAB526HXQ	A302-834A	1	Released	ENCODE3
SLTM	227	HepG2	ENCSR351PVI	ENCSR670UPZ	ENCAB526HXQ	A302-834A	1	Released	ENCODE3

Antibody Validation

GeneName	Antibody_DCC_ID	Product_ID	Lot_ID	Phosphate	HepG2 Primary Validation	K562 Primary Validation	HepG2 Secondary Validation	K562 Secondary Validation
SLTM	ENCAB526HXQ	A302-834A	1		Released, ENCODE3	Released, ENCODE3	BGHLV14-47, Released, ENCODE3	BGKLV13-57, Released, ENCODE3

KD RNA-Seq

GeneName	Cell_Line	Method	Exp_ID	Control_ID	Sample_reps	Control_reps	KD%	Status	Project	Note
SLTM	K562	shRNA	ENCSR234YMW	ENCSR084SCN	SLTM_BGKLV13_57,SLTM_BGKLV13_58	non-target_BGKLV13_73,non-target_BGKLV13_74	59.3,58.5	Released	ENCODE3
SLTM	HepG2	shRNA	ENCSR185JGT	ENCSR491FOC	SLTM_BGHLV14-47,SLTM_BGHLV14-48	NT_BGHLV14-1,NT_BGHLV14-2	86.3,69.3	Released	ENCODE3

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

SLTM: Click to RBP Image Database

Nuclei

Nucleoplasm

Mutually Exclusive from Nucleolus

Cytoplasm

Cytoskeleton

Microtubule

Mitotic-Apparatus (Spindle; Centrosomes)

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela
SLTM	Product_ID: A302-834A Lot_ID: 1 Source: Bethyl Labs Target Name: SLTM-human

RNA Targets

SLTM protein binds to 4,839 RNA regions.

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Proteins bound to RNA

SLTM RNA is bound by 32 proteins.

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SLTM protein has 4,839 RNA targets:

Only display 100 entries as example. Please click "View All" button to see all 4,839 entries.

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RBP	Chr	Start	End	Strand	log2(fold change)	-log(p-value)	Cell Line	Matched Gene	Matched Area
SLTM	chr11	3415186	3415267	+	4.71613	24.71444	K562	TSSC2	intron-Distal
SLTM	chr11	62296432	62296510	-	3.90642	18.52723	K562	AHNAK	CDS,intron-Distal
SLTM	chr16	89350045	89350149	-	4.75986	18.43719	K562	ANKRD11	3'-UTR,CDS,intron-Distal
SLTM	chr6	170124070	170124145	-	4.01013	17.72635	HepG2	PHF10	5'-UTR,intron-Distal,intron-Proximal
SLTM	chr8	94752537	94752633	-	4.11594	17.71899	K562	RBM12B	intron-Distal
SLTM	chr16	89032547	89032624	-	3.08888	16.56758	K562	CBFA2T3	intron-Distal
SLTM	chr18	75689974	75689996	-	3.59431	15.78344	K562	LINC01029	intron-Distal
SLTM	chr7	1881353	1881424	-	5.12769	15.36100	K562	MAD1L1	intron-Distal
SLTM	chr22	45723947	45724000	+	6.31897	15.29961	HepG2	FAM118A	intron-Proximal
SLTM	chr21	47560131	47560224	-	3.57184	15.29531	HepG2	FTCD	intron-Distal

Showing 1 to 10 of 100 entries

32 proteins are bound to SLTM RNA:

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Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr15	59179172	59179283	-	3'-UTR,CDS,intron-Distal,intron-Proximal	4.22474	21.02818	K562	UCHL5
chr15	59175896	59175986	-	3'-UTR,CDS,intron-Distal,intron-Proximal	4.42810	19.15694	K562	UCHL5
chr15	59191725	59191822	-	CDS,intron-Distal,intron-Proximal	3.95837	18.58100	K562	UCHL5
chr15	59180756	59180893	-	CDS,intron-Distal,intron-Proximal	4.43913	18.37390	K562	KHSRP
chr15	59179467	59179548	-	3'-UTR,CDS,intron-Distal,intron-Proximal	4.21866	16.99302	K562	UCHL5
chr15	59191664	59191839	-	CDS,intron-Distal,intron-Proximal	4.46797	15.61961	HepG2	GRWD1
chr15	59185163	59185249	-	3'-UTR,CDS,intron-Distal	4.15149	15.17442	K562	UCHL5
chr15	59205706	59205876	-	3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal	3.41679	14.47671	HepG2	BCLAF1
chr15	59186719	59186781	-	3'-UTR,CDS,intron-Distal	5.90195	14.11692	K562	ZNF622
chr15	59186032	59186097	-	3'-UTR,CDS,intron-Distal,intron-Proximal	4.12319	13.82685	K562	UCHL5
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

Showing 1 to 10 of 162 entries

No autoregularoty interactions between protein SLTM and its RNA.

Diffrential Expression

727 differentially expressed genes after Knockdown/Knockout SLTM protein.

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104 RBPs can affect the levels of SLTM.

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727 differentially expressed genes after Knockdown/Knockout SLTM protein :

Only display 100 entries as example. Please click "View All" button to see all 727 entries.

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Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
AGR2	ENSG00000106541.7	407.20990	45.84160	3.15090	27.41410	23.74520	HepG2	SLTM
ACSM2B	ENSG00000066813.10	1753.88780	400.39240	2.13100	20.15310	16.73940	HepG2	SLTM
TBX15	ENSG00000092607.9	149.56430	25.14010	2.57260	12.70940	9.68390	HepG2	SLTM
CYP3A5	ENSG00000106258.9	578.36280	167.41010	1.78850	12.54910	9.56140	HepG2	SLTM
CDH1	ENSG00000039068.14	2821.82100	972.04720	1.53740	11.68870	8.76790	HepG2	SLTM
SYP	ENSG00000102003.6	286.72860	79.98650	1.84180	10.46160	7.59890	HepG2	SLTM
STRADB	ENSG00000082146.8	415.24670	1141.04000	-1.45830	9.85450	7.10990	HepG2	SLTM
ANXA13	ENSG00000104537.12	130.22120	26.97680	2.27110	9.83230	7.10790	HepG2	SLTM
SAMHD1	ENSG00000101347.7	324.73560	896.56540	-1.46510	9.61400	6.89940	HepG2	SLTM
FGFR1	ENSG00000077782.15	676.60330	1704.63230	-1.33310	8.90920	6.24030	HepG2	SLTM
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 100 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

104 RBPs can affect the gene expression of SLTM :

Show entries

Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
SLTM	ENSG00000137776.12	3310.24250	1795.26650	0.88260	29.51790	27.67620	K562	FXR1
SLTM	ENSG00000137776.12	1396.34310	2831.95040	-1.02010	29.73130	25.36420	K562	SLTM
SLTM	ENSG00000137776.12	1727.66050	2703.22090	-0.64590	23.57950	22.37370	HepG2	ZNF622
SLTM	ENSG00000137776.12	1248.65620	2962.50580	-1.24640	23.64560	21.97780	HepG2	GPKOW
SLTM	ENSG00000137776.12	1230.95860	2247.89850	-0.86880	19.90390	18.34710	HepG2	SRSF7
SLTM	ENSG00000137776.12	1158.76580	2218.60600	-0.93710	19.16540	17.78320	HepG2	PUF60
SLTM	ENSG00000137776.12	2670.73830	4145.65490	-0.63440	16.91800	15.63750	K562	AGGF1
SLTM	ENSG00000137776.12	8494.04280	5949.73540	0.51350	15.45740	14.03110	K562	DDX47
SLTM	ENSG00000137776.12	953.90510	1719.09560	-0.84970	13.87740	12.43920	HepG2	HNRNPC
SLTM	ENSG00000137776.12	1636.61000	2755.49230	-0.75160	12.00630	10.65840	HepG2	TARDBP
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 121 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

85 alternative splicing events after Knockdown/Knockout SLTM protein :

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Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	FDR	is_included	Cell Line	Affected by RBP
SE	PLOD2	ENSG00000152952.7	chr3	-	145795648	145795711	145794568	145794682	145796902	145797044	0.13600	0.00501	included	HepG2	SLTM
SE	APOC1	ENSG00000130208.5	chr19	+	45418128	45418184	45417966	45417990	45419446	45419616	0.18900	0.00059	included	HepG2	SLTM
SE	SEC31A	ENSG00000138674.12	chr4	-	83752089	83752128	83750152	83750211	83763292	83763634	0.31500	0.00001	included	HepG2	SLTM
SE	NSFL1C	ENSG00000088833.13	chr20	-	1426639	1426794	1426310	1426475	1433137	1433275	0.06000	0.00001	included	HepG2	SLTM
SE	SAT1	ENSG00000130066.12	chrX	+	23802410	23802520	23801916	23802000	23803444	23803546	0.11000	0.00000	included	HepG2	SLTM
SE	NINL	ENSG00000101004.10	chr20	-	25460199	25460308	25459558	25459842	25460796	25460903	0.06000	0.00468	included	HepG2	SLTM
SE	AP1G2	ENSG00000213983.7	chr14	-	24032408	24032511	24031712	24031802	24032588	24032847	0.17700	0.00295	included	HepG2	SLTM
SE	FDPS	ENSG00000160752.10	chr1	+	155279579	155279756	155278642	155278756	155279833	155279996	0.11200	0.00120	included	HepG2	SLTM
SE	CEPT1	ENSG00000134255.9	chr1	+	111715735	111715880	111703776	111703918	111717500	111717585	0.27700	0.00002	included	HepG2	SLTM
SE	FN1	ENSG00000115414.14	chr2	-	216257653	216257926	216256354	216256537	216259250	216259442	0.16500	0.00000	included	HepG2	SLTM

Showing 1 to 10 of 85 entries

18 RBPs can affect the splicing of SLTM :

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Search:

Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	FDR	is_included	Cell Line	Affected by RBP
SE	SLTM	ENSG00000137776.12	chr15	-	59186631	59186781	59186288	59186392	59189313	59189432	-0.13700	0.00000	excluded	K562	SF3B4
SE	SLTM	ENSG00000137776.12	chr15	-	59205697	59205895	59204761	59204809	59209133	59209198	-0.29100	0.00000	excluded	HepG2	U2AF1
SE	SLTM	ENSG00000137776.12	chr15	-	59205697	59205895	59204761	59204809	59209133	59209198	-0.23100	0.00000	excluded	HepG2	U2AF2
SE	SLTM	ENSG00000137776.12	chr15	-	59182479	59182660	59181628	59181753	59185095	59185259	-0.29800	0.00000	excluded	K562	AQR
SE	SLTM	ENSG00000137776.12	chr15	-	59189313	59189432	59186657	59186781	59209133	59209198	-0.09200	0.00000	excluded	K562	PUS1
SE	SLTM	ENSG00000137776.12	chr15	-	59182479	59182660	59181628	59181753	59185095	59185259	-0.15900	0.00015	excluded	HepG2	SF3A3
SE	SLTM	ENSG00000137776.12	chr15	-	59182479	59182660	59181628	59181753	59185095	59185259	-0.25600	0.00008	excluded	HepG2	HNRNPC
A3SS	SLTM	ENSG00000137776.12	chr15	-	59209133	59209240	59209133	59209198	59224554	59224642	0.17800	0.00000	longer	K562	AQR
A3SS	SLTM	ENSG00000137776.12	chr15	-	59205697	59205944	59205697	59205895	59209133	59209297	0.06700	0.00000	longer	K562	AQR
A3SS	SLTM	ENSG00000137776.12	chr15	-	59185095	59185306	59185095	59185259	59185477	59185593	0.07100	0.00000	longer	K562	AQR

Showing 1 to 10 of 40 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

SLTM

General Information

Functions

Localization(RBPImage: SLTM)

Domains (AlphaFold: SLTM)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

SLTM protein has 4,839 RNA targets:

32 proteins are bound to SLTM RNA:

No autoregularoty interactions between protein SLTM and its RNA.

Diffrential Expression

727 differentially expressed genes after Knockdown/Knockout SLTM protein :

104 RBPs can affect the gene expression of SLTM :

85 alternative splicing events after Knockdown/Knockout SLTM protein :

18 RBPs can affect the splicing of SLTM :

No autoregularoty alternative splicing events between protein SLTM and its RNA.