NLE1

General Information

Gene Name       : NLE1
Gene ID             : ENSG00000073536.17
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: NLE1)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878NLE1ENSG00000073536.175.079.247.16ENCSR000AEF
HepG2NLE1ENSG00000073536.1728.0712.4420.25ENCSR985KAT
K562NLE1ENSG00000073536.1733.1919.7626.48ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for NLE1 is not avaliable on ENCORE database.



Proteins bound to RNA
  • NLE1 RNA is bound by 10 proteins.  







eCLIP assay for NLE1 is not avaliable on ENCORE database.





10 proteins are bound to NLE1 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr173345869533458738-3'-UTR,intron-Distal4.413854.22051K562UPF1
chr173345897333459051-3'-UTR,intron-Distal,intron-Proximal3.871414.82552K562UPF1
chr173345909833459164-3'-UTR,intron-Distal,intron-Proximal5.1382414.52874K562PUM2
chr173345696633457009-3'-UTR,intron-Distal3.545374.14074K562UPF1
chr173346416933464214-3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal3.267183.05161HepG2PPIG
chr173346401933464073-3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal4.244753.71984K562METAP2
chr173345886233458952-3'-UTR,intron-Distal5.252897.70404K562UPF1
chr173346403533464100-3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal4.413109.80049K562YBX3
chr173345898733459072-3'-UTR,intron-Distal,intron-Proximal4.036113.08342HepG2AKAP1
chr173346456033464620-3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal3.627124.41267HepG2PPIG
chr173345915733459365-3'-UTR,intron-Distal,intron-Proximal4.768286.20043HepG2UPF1
chr173346920233469272-5'-UTR,intron-Distal,intron-Proximal3.586754.41726HepG2NKRF
chr173346891533469008-5'-UTR,CDS,intron-Distal,intron-Proximal4.4687712.81328HepG2PRPF8
chr173346916033469291-5'-UTR,CDS,intron-Distal,intron-Proximal4.171833.86417HepG2PRPF4
chr173346316233463282-CDS,intron-Distal,intron-Proximal5.675358.50915HepG2EFTUD2
chr173346014233460231-CDS,intron-Distal,intron-Proximal3.969286.23016HepG2PRPF8
chr173346017033460256-CDS,intron-Distal,intron-Proximal4.069035.80295HepG2PPIG
chr173346314733463229-CDS,intron-Distal,intron-Proximal6.0814711.46503HepG2PRPF8
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for NLE1 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for NLE1 is not available on ENCORE database.

  • 110 RBPs can affect the levels of NLE1.  








The Knockdown/knockout RNA-Seq assay for NLE1 is not available on ENCORE database.





110 RBPs can affect the gene expression of NLE1 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
NLE1ENSG00000073536.13418.97150579.81040-0.468702.588401.67700HepG2ABCF1
NLE1ENSG00000073536.13304.59240547.65530-0.8464011.8110010.74210HepG2ACO1
NLE1ENSG00000073536.13602.921201030.14450-0.772806.905506.10700HepG2AKAP1
NLE1ENSG00000073536.13331.39240526.34980-0.667504.772603.42010HepG2AKAP8
NLE1ENSG00000073536.13390.12310550.20010-0.496004.579503.61130HepG2AKAP8L
NLE1ENSG00000073536.13506.16710852.33550-0.751807.214305.97530HepG2ASCC1
NLE1ENSG00000073536.13682.262301038.95240-0.606709.625808.47520HepG2AUH
NLE1ENSG00000073536.13267.06990399.53670-0.581103.009002.06960HepG2BCLAF1
NLE1ENSG00000073536.13420.20700296.719400.501902.879102.26900HepG2BOP1
NLE1ENSG00000073536.13266.04380434.32100-0.707105.725703.99850HepG2BUD13
NLE1ENSG00000073536.13214.94550353.31620-0.717005.066204.06110HepG2CALR
NLE1ENSG00000073536.13504.91750809.78470-0.681506.071804.95760HepG2CIRBP
NLE1ENSG00000073536.13267.72580491.53440-0.876505.170904.11990HepG2CNOT7
NLE1ENSG00000073536.13240.36720413.68870-0.783306.201805.23420HepG2DDX21
NLE1ENSG00000073536.13366.44640986.75200-1.4291022.6053020.99630HepG2DDX3X
NLE1ENSG00000073536.13390.78960543.90050-0.477003.130001.76000HepG2DDX47
NLE1ENSG00000073536.13256.90320452.19530-0.815706.043004.95380HepG2DDX55
NLE1ENSG00000073536.13375.24800847.75460-1.1758013.6888012.44410HepG2DDX6
NLE1ENSG00000073536.13348.90130523.94890-0.586605.010504.14760HepG2DKC1
NLE1ENSG00000073536.13254.72770408.32410-0.680804.127103.02520HepG2EEF2
NLE1ENSG00000073536.13241.80650340.39390-0.493402.447501.40560HepG2EFTUD2
NLE1ENSG00000073536.13404.43760814.85370-1.0106011.4195010.26390HepG2EIF2S1
NLE1ENSG00000073536.13221.36000331.46500-0.582503.020402.08010HepG2EIF3D
NLE1ENSG00000073536.13557.25260900.45440-0.692305.881204.95000HepG2EIF4A3
NLE1ENSG00000073536.13572.14680876.82330-0.615903.834703.02920HepG2EIF4B
NLE1ENSG00000073536.13477.21120619.16120-0.375702.122101.40290HepG2EIF4G2
NLE1ENSG00000073536.13702.015501192.85730-0.7648015.3953014.16460HepG2ETF1
NLE1ENSG00000073536.13394.09950585.44670-0.571003.368802.52670HepG2FIP1L1
NLE1ENSG00000073536.13265.29670376.34330-0.504402.876501.58110HepG2FKBP4
NLE1ENSG00000073536.13415.11940548.52670-0.402002.549701.79410HepG2FUBP3
NLE1ENSG00000073536.13566.18290908.68650-0.682506.305405.28700HepG2FXR1
NLE1ENSG00000073536.13346.45010842.85280-1.2826017.3207015.72800HepG2G3BP1
NLE1ENSG00000073536.13663.18310894.91030-0.432303.003902.07510HepG2G3BP2
NLE1ENSG00000073536.13251.01420416.97200-0.732203.867302.66080HepG2GNB2L1
NLE1ENSG00000073536.13181.87050308.75780-0.763604.149703.37740HepG2GPKOW
NLE1ENSG00000073536.13214.89700336.66910-0.647703.583702.86040HepG2HNRNPA1
NLE1ENSG00000073536.13393.53940602.09680-0.613506.356505.03980HepG2HNRNPA2B1
NLE1ENSG00000073536.13207.60350294.65550-0.505202.209301.64020HepG2HNRNPLL
NLE1ENSG00000073536.13269.19770372.01150-0.466703.162402.51810HepG2HNRNPU
NLE1ENSG00000073536.13397.40330856.71040-1.1082014.1811012.78680HepG2IGF2BP2
NLE1ENSG00000073536.13442.25620804.11070-0.862502.784701.80000HepG2IGF2BP3
NLE1ENSG00000073536.13277.16860479.21750-0.789904.859003.08700HepG2ILF3
NLE1ENSG00000073536.13395.07970572.57290-0.535302.866501.59610HepG2KRR1
NLE1ENSG00000073536.13595.81240909.00450-0.609404.990404.11800HepG2MAGOH
NLE1ENSG00000073536.13642.30140914.06510-0.509003.426802.73120HepG2MATR3
NLE1ENSG00000073536.13299.93070473.72260-0.659405.194604.11310HepG2MSI2
NLE1ENSG00000073536.13200.02250300.56280-0.587502.199201.34170HepG2MTPAP
NLE1ENSG00000073536.13449.24320935.57460-1.0584012.9244011.61300HepG2NCBP2
NLE1ENSG00000073536.13163.94260261.28590-0.672403.167302.36770HepG2NSUN2
NLE1ENSG00000073536.13208.58750449.30860-1.107107.055705.59330HepG2PABPC1
NLE1ENSG00000073536.13418.33930833.08940-0.9938011.4919010.04770HepG2PABPC4
NLE1ENSG00000073536.13282.44270413.42410-0.549702.518901.52860HepG2PCBP2
NLE1ENSG00000073536.13620.21250508.370800.286802.009401.34320HepG2PRPF4
NLE1ENSG00000073536.13206.07860348.64750-0.758605.028203.97310HepG2PRPF8
NLE1ENSG00000073536.13406.05670844.35410-1.0562020.4462019.22300HepG2PTBP1
NLE1ENSG00000073536.13367.40210557.81750-0.602406.780705.88970HepG2PUS1
NLE1ENSG00000073536.13444.71730914.54130-1.0402018.7862017.36020HepG2QKI
NLE1ENSG00000073536.13234.78180398.85570-0.764503.392502.61390HepG2RAVER1
NLE1ENSG00000073536.13413.15550548.74200-0.409403.006002.11410HepG2RBM15
NLE1ENSG00000073536.13693.34120997.00780-0.524006.076305.38200HepG2RBM22
NLE1ENSG00000073536.13455.57610829.97290-0.8654011.8042010.47190HepG2RBM25
NLE1ENSG00000073536.13532.60750939.71820-0.8192014.2936013.24400HepG2NELFE
NLE1ENSG00000073536.13649.57740875.15970-0.430004.784904.00400HepG2RECQL
NLE1ENSG00000073536.13330.40830467.29820-0.500103.134902.41470HepG2RPLP0
NLE1ENSG00000073536.13207.88250391.99530-0.915105.435104.13610HepG2RPS10
NLE1ENSG00000073536.13183.46490322.53440-0.813905.784304.93340HepG2RPS19
NLE1ENSG00000073536.13317.54790454.44390-0.517102.617901.83830HepG2RPS2
NLE1ENSG00000073536.13278.78360493.71640-0.824505.550504.41140HepG2RPS3A
NLE1ENSG00000073536.13223.79620344.86640-0.623903.470202.60360HepG2RRP9
NLE1ENSG00000073536.13436.94310291.636800.583203.695502.89070HepG2SF3B1
NLE1ENSG00000073536.13566.49590879.15310-0.634009.092208.11420HepG2SF3B4
NLE1ENSG00000073536.13212.46820389.34940-0.873803.470001.68070HepG2SLTM
NLE1ENSG00000073536.13212.80980324.50210-0.608702.346501.62980HepG2SNRNP70
NLE1ENSG00000073536.13946.196101126.08320-0.251102.187801.72570HepG2SRFBP1
NLE1ENSG00000073536.13383.60270917.61630-1.2583029.8075028.62070HepG2SRSF1
NLE1ENSG00000073536.13356.31980612.30690-0.781109.887708.80130HepG2SRSF5
NLE1ENSG00000073536.13463.05300746.50460-0.6890010.373409.42330HepG2SRSF9
NLE1ENSG00000073536.13552.20350977.70620-0.8242016.3469015.31540HepG2SSB
NLE1ENSG00000073536.13254.97820390.94830-0.616602.873401.61660HepG2STAU1
NLE1ENSG00000073536.13292.99180429.52740-0.551902.983201.83560HepG2STIP1
NLE1ENSG00000073536.13138.39030450.09990-1.7015016.4716015.06290HepG2SUPV3L1
NLE1ENSG00000073536.13427.15790824.70840-0.9491016.0634014.87820HepG2TAF15
NLE1ENSG00000073536.13197.72330301.65360-0.609402.990701.95580HepG2TFIP11
NLE1ENSG00000073536.13492.28480757.88050-0.622506.965005.64570HepG2TIA1
NLE1ENSG00000073536.13197.11740361.45750-0.874807.679706.92310HepG2TIAL1
NLE1ENSG00000073536.13481.67000364.711400.401203.129502.53780HepG2TRIM56
NLE1ENSG00000073536.13362.53930500.75490-0.466002.687302.06680HepG2U2AF1
NLE1ENSG00000073536.13271.22820471.90800-0.799009.265508.11740HepG2UPF1
NLE1ENSG00000073536.13598.85300455.608500.394303.275502.63380HepG2UTP3
NLE1ENSG00000073536.13356.06460501.71270-0.494704.550303.72380HepG2ZC3H8
NLE1ENSG00000073536.13280.18550519.00830-0.8894012.8618011.90070HepG2ZNF622
NLE1ENSG00000073536.13694.57000873.46550-0.330602.781101.60270K562CCDC124
NLE1ENSG00000073536.13336.51780482.71210-0.520503.731002.82100K562CPSF6
NLE1ENSG00000073536.13912.96940724.769500.332902.815101.48320K562DDX27
NLE1ENSG00000073536.13419.26800550.20470-0.392102.629001.61480K562DDX3X
NLE1ENSG00000073536.131208.24110804.549500.586609.666808.53680K562DDX47
NLE1ENSG00000073536.13794.658601145.43720-0.527507.503506.40450K562EIF2S2
NLE1ENSG00000073536.13680.79330361.355700.9137013.1071011.34010K562EIF3G
NLE1ENSG00000073536.131045.54280574.799600.8630012.0827010.32530K562EIF4A3
NLE1ENSG00000073536.13347.40070491.14830-0.499603.101002.19000K562FMR1
NLE1ENSG00000073536.13272.87880416.29260-0.609303.684902.61580K562FTO
NLE1ENSG00000073536.131036.01060597.762500.7933013.7387012.49460K562FXR1
NLE1ENSG00000073536.13136.58430274.35390-1.006205.947504.82380K562G3BP2
NLE1ENSG00000073536.13751.63940552.482100.444002.612701.71060K562HNRNPM
NLE1ENSG00000073536.131035.85310509.691101.0230017.7774015.49560K562MAGOH
NLE1ENSG00000073536.13727.69940508.617000.516704.751103.50750K562MATR3
NLE1ENSG00000073536.131143.117801476.67430-0.369402.867101.71390K562MSI2
NLE1ENSG00000073536.13692.66750498.345700.474904.116702.45100K562PCBP1
NLE1ENSG00000073536.13587.49350850.32560-0.533404.012203.00900K562PCBP3
NLE1ENSG00000073536.13507.48590652.20290-0.362002.503401.74380K562POLR2G
NLE1ENSG00000073536.13781.51440495.216500.658102.329901.71360K562PTBP1
NLE1ENSG00000073536.13657.43230474.709700.469703.514002.56210K562RBM22
NLE1ENSG00000073536.13802.67520581.209500.465703.836102.55360K562SAFB
NLE1ENSG00000073536.13519.85940285.159000.866304.057603.01480K562SF3B4
NLE1ENSG00000073536.13570.45940427.046400.417602.529301.56020K562SRFBP1
NLE1ENSG00000073536.13446.62800332.146900.427202.326801.37540K562SRSF4
NLE1ENSG00000073536.131015.53140654.212200.634308.171806.75400K562SYNCRIP
NLE1ENSG00000073536.13706.93380491.300900.524904.076203.21080K562TARDBP
NLE1ENSG00000073536.13725.83370473.931900.614906.207004.90980K562TIA1
NLE1ENSG00000073536.13629.78090465.218800.436802.911501.78510K562TRA2A
NLE1ENSG00000073536.13679.86390504.523300.430202.643501.72380K562TRIM56
NLE1ENSG00000073536.13495.79200717.05900-0.532404.135302.86590K562UCHL5
NLE1ENSG00000073536.13687.58000874.66570-0.347203.618402.80460K562UPF1
NLE1ENSG00000073536.13554.59710748.42720-0.432403.537302.54960K562WDR3
NLE1ENSG00000073536.131054.61570660.884700.674103.244601.49750K562XRCC6
NLE1ENSG00000073536.131015.147701448.98320-0.513403.602402.59300K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for NLE1 is not available on ENCORE database.





5 RBPs can affect the splicing of NLE1 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SENLE1ENSG00000073536.13chr17-334619613346207833460357334605173346226733462470-0.142000.000750.05429excludedHepG2HNRNPL
SENLE1ENSG00000073536.13chr17-334645613346465933464071334642123346483233464909-0.192000.000120.00449excludedHepG2SRSF1
SENLE1ENSG00000073536.13chr17-334645613346465933464071334642123346483233464909-0.094000.000930.08985excludedHepG2SSB
SENLE1ENSG00000073536.13chr17-334668673346708533466253334663333346899733469303-0.150000.002590.04175excludedK562HNRNPC
A3SSNLE1ENSG00000073536.13chr17-3346338033463562334633803346351633464019334642120.051000.000540.00399longerK562AQR
A3SSNLE1ENSG00000073536.13chr17-3346625333466360334662533346633333466867334670850.080000.000050.00047longerK562AQR
A5SSNLE1ENSG00000073536.13chr17-3346683833467085334668673346708533466253334663330.105000.000250.00572longerK562AQR

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for NLE1 is not avaliable on ENCORE database.