MTHFD2

General Information

Gene Name : MTHFD2
Gene ID : ENSG00000065911.11
Essential Gene : Yes

Functions

Not Available

Localization

Not Available

Domains (AlphaFold: MTHFD2)

Not Available

Antibody Validation

Not Avaiable

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	MTHFD2	ENSG00000065911.11	96.30	87.75	92.03	ENCSR000AEF
HepG2	MTHFD2	ENSG00000065911.11	80.42	108.30	94.36	ENCSR985KAT
K562	MTHFD2	ENSG00000065911.11	151.17	117.83	134.50	ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.

eCLIP

No eCLIP experiment available

Antibody Validation

No Antibody Primary Validation image or Secondary image available

KD RNA-Seq

No KD RNA-Seq experiment available

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

No Localization Information available

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela

Summary
Proteins Bound to RBP RNA

RNA Targets

eCLIP assay for MTHFD2 is not avaliable on ENCORE database.

Proteins bound to RNA

MTHFD2 RNA is bound by 27 proteins.

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eCLIP assay for MTHFD2 is not avaliable on ENCORE database.

27 proteins are bound to MTHFD2 RNA:

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Search:

Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr2	74441381	74441395	+	3'-UTR	4.45612	55.19753	K562	YBX3
chr2	74435761	74435833	+	3'-UTR,CDS,intron-Distal	4.53705	46.84741	K562	PUM2
chr2	74441363	74441370	+	3'-UTR,CDS	4.55081	44.94858	K562	YBX3
chr2	74441395	74441409	+	3'-UTR	4.37773	39.67097	K562	YBX3
chr2	74425778	74425822	+	5'-UTR,CDS	3.50390	29.45322	K562	YBX3
chr2	74432970	74432985	+	CDS,intron-Distal	3.95155	26.17428	K562	YBX3
chr2	74432952	74432970	+	CDS,intron-Distal	4.11306	22.29095	K562	YBX3
chr2	74442285	74442367	+	3'-UTR	5.28584	19.60667	HepG2	SUB1
chr2	74425842	74425866	+	5'-UTR,CDS	3.75542	19.48629	K562	YBX3
chr2	74432831	74432839	+	CDS,intron-Distal,intron-Proximal	4.97949	18.09367	K562	YBX3
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

Showing 1 to 10 of 85 entries

eCLIP assay for MTHFD2 is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout assay for MTHFD2 is not available on ENCORE database.
147 RBPs can affect the levels of MTHFD2.

CanvasJS.com

The Knockdown/knockout RNA-Seq assay for MTHFD2 is not available on ENCORE database.

147 RBPs can affect the gene expression of MTHFD2 :

Show entries

Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
MTHFD2	ENSG00000065911.7	427.51730	2002.02820	-2.22740	100.20420	98.02230	HepG2	TIAL1
MTHFD2	ENSG00000065911.7	760.02970	2104.58860	-1.46940	87.77170	84.82240	HepG2	ILF2
MTHFD2	ENSG00000065911.7	693.23200	4660.26170	-2.74900	80.24390	76.94010	HepG2	G3BP1
MTHFD2	ENSG00000065911.7	1078.07100	4606.84820	-2.09530	60.19910	56.82700	HepG2	PABPC4
MTHFD2	ENSG00000065911.7	1843.14230	6371.28220	-1.78940	41.08120	39.66170	HepG2	SSB
MTHFD2	ENSG00000065911.7	3628.16880	1886.52030	0.94340	39.93590	37.01060	HepG2	HDGF
MTHFD2	ENSG00000065911.7	766.25670	2074.07130	-1.43660	37.84310	35.62430	HepG2	HNRNPC
MTHFD2	ENSG00000065911.7	3847.28040	8173.97970	-1.08720	37.16070	34.62730	K562	SRSF1
MTHFD2	ENSG00000065911.7	927.32240	2375.85430	-1.35730	35.89620	34.07830	HepG2	RPLP0
MTHFD2	ENSG00000065911.7	2287.39320	4700.56140	-1.03910	35.01090	33.50730	HepG2	PTBP1
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 190 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

The Knockdown/knockout RNA-Seq assay for MTHFD2 is not available on ENCORE database.

15 RBPs can affect the splicing of MTHFD2 :

Show entries

Search:

Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	2ndExonStart	2ndExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	p-value	FDR	is_included	Cell Line	Affected by RBP
SE	MTHFD2	ENSG00000065911.7	chr2	+	74432831	74433016			74425742	74425869	74434830	74434953	-0.10500	0.00000	0.00018	excluded	K562	EFTUD2
SE	MTHFD2	ENSG00000065911.7	chr2	+	74433108	74433215			74432831	74433016	74434830	74434953	0.05700	0.00000	0.00000	included	K562	U2AF1
SE	MTHFD2	ENSG00000065911.7	chr2	+	74432831	74433016			74425742	74425869	74434830	74434953	-0.09800	0.00000	0.00139	excluded	K562	SBDS
SE	MTHFD2	ENSG00000065911.7	chr2	+	74433108	74433215			74432831	74433016	74434830	74434953	0.07100	0.00000	0.00000	included	K562	U2AF2
SE	MTHFD2	ENSG00000065911.7	chr2	+	74432831	74433016			74425742	74425869	74434830	74434953	-0.18600	0.00000	0.00000	excluded	K562	HNRNPU
SE	MTHFD2	ENSG00000065911.7	chr2	+	74432831	74433016			74425742	74425869	74434830	74434953	-0.19200	0.00000	0.00000	excluded	HepG2	HNRNPU
A3SS	MTHFD2	ENSG00000065911.7	chr2	+	74435670	74435848			74435695	74435848	74434830	74434953	0.07200	0.00000	0.00000	longer	K562	AQR
MXE	MTHFD2	ENSG00000065911.7	chr2	+	74432831	74433016	74433108	74433215	74425741	74425869	74434830	74434953	-0.05900	0.00000	0.00000	2included	K562	U2AF2
SE	MTHFD2	ENSG00000065911.7	chr2	+	74432831	74433016			74425742	74425869	74434830	74434953	-0.09200	0.00001	0.01206	excluded	K562	XRN2
SE	MTHFD2	ENSG00000065911.7	chr2	+	74432831	74433016			74425742	74425869	74434830	74434953	-0.08500	0.00001	0.00085	excluded	K562	TARDBP

Showing 1 to 10 of 21 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

MTHFD2

General Information

Functions

Localization

Domains (AlphaFold: MTHFD2)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

eCLIP assay for MTHFD2 is not avaliable on ENCORE database.

27 proteins are bound to MTHFD2 RNA:

eCLIP assay for MTHFD2 is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout RNA-Seq assay for MTHFD2 is not available on ENCORE database.

147 RBPs can affect the gene expression of MTHFD2 :

The Knockdown/knockout RNA-Seq assay for MTHFD2 is not available on ENCORE database.

15 RBPs can affect the splicing of MTHFD2 :

The Knockdown/knockout RNA-Seq assay for MTHFD2 is not avaliable on ENCORE database.