TMEM126B

General Information

Gene Name       : TMEM126B
Gene ID             : ENSG00000171204.12
Essential Gene : No

Functions

Localization

Domains (AlphaFold: TMEM126B)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878TMEM126BENSG00000171204.1268.5245.3056.91ENCSR000AEF
HepG2TMEM126BENSG00000171204.1230.8853.7042.29ENCSR985KAT
K562TMEM126BENSG00000171204.1293.8396.5195.17ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for TMEM126B is not avaliable on ENCORE database.



Proteins bound to RNA
  • TMEM126B RNA is bound by 8 proteins.  







eCLIP assay for TMEM126B is not avaliable on ENCORE database.





8 proteins are bound to TMEM126B RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr118534707985347143+3'-UTR,CDS,intron-Proximal3.250394.81700HepG2U2AF2
chr118534744985347520+3'-UTR4.663344.61859K562IGF2BP1
chr118534695785347049+3'-UTR,intron-Distal,intron-Proximal3.706665.36861HepG2U2AF2
chr118534275185342816+3'-UTR,5'-UTR,CDS,intron-Distal3.469143.87469HepG2BCLAF1
chr118534525685345363+3'-UTR,CDS,intron-Distal,intron-Proximal3.434558.79239K562KHSRP
chr118534688485346960+3'-UTR,intron-Distal,intron-Proximal4.359824.90467K562U2AF2
chr118534688485346957+3'-UTR,intron-Distal,intron-Proximal4.235549.06734HepG2U2AF2
chr118534688085346929+3'-UTR,intron-Distal,intron-Proximal3.436034.35112K562U2AF1
chr118533964285339735+5'-UTR,CDS,intron-Proximal3.2880310.22714K562DDX3X
chr118533963885339742+5'-UTR,CDS,intron-Proximal3.890815.11373HepG2NCBP2
chr118534091485340960+intron-Distal3.323893.16095HepG2U2AF2
chr118534170285341767+intron-Distal3.477613.55754HepG2U2AF2
chr118534251885342648+intron-Distal,intron-Proximal4.7578011.50600HepG2QKI
chr118534252185342699+intron-Distal,intron-Proximal4.894529.72850K562QKI
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for TMEM126B is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for TMEM126B is not available on ENCORE database.

  • 43 RBPs can affect the levels of TMEM126B.  








The Knockdown/knockout RNA-Seq assay for TMEM126B is not available on ENCORE database.





43 RBPs can affect the gene expression of TMEM126B :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
TMEM126BENSG00000171204.8296.10520378.36760-0.353701.987101.37230HepG2HNRNPF
TMEM126BENSG00000171204.8403.05980495.24080-0.297101.996001.41180HepG2HNRNPL
TMEM126BENSG00000171204.8270.72660372.58510-0.460702.642701.93450HepG2IGF2BP1
TMEM126BENSG00000171204.8185.53750260.30230-0.488502.558501.84700HepG2PPIL4
TMEM126BENSG00000171204.8408.13570545.89930-0.419602.849002.16920HepG2PUM2
TMEM126BENSG00000171204.8722.26260542.483900.412802.581702.07660HepG2RBM22
TMEM126BENSG00000171204.8190.01920259.90250-0.451802.339001.73870HepG2SAFB2
TMEM126BENSG00000171204.8450.08330292.712100.620602.096201.50800HepG2SF3A3
TMEM126BENSG00000171204.8341.52310493.45140-0.530904.851903.96370HepG2SLBP
TMEM126BENSG00000171204.8750.79710612.724200.293102.439901.95890HepG2SRFBP1
TMEM126BENSG00000171204.8652.07890387.159100.752009.199708.44960HepG2SRSF1
TMEM126BENSG00000171204.8437.12850291.520600.584402.971901.92670HepG2SRSF3
TMEM126BENSG00000171204.8447.90770347.970900.364102.094201.59360HepG2TAF15
TMEM126BENSG00000171204.8197.27160283.59660-0.523702.773702.27220HepG2TIAL1
TMEM126BENSG00000171204.8453.30010274.831100.721804.957904.13080HepG2U2AF1
TMEM126BENSG00000171204.8379.25370215.582900.814806.066404.93410HepG2UCHL5
TMEM126BENSG00000171204.8378.19170250.626700.593502.876302.26920HepG2UTP3
TMEM126BENSG00000171204.81045.453301384.79980-0.405503.335101.97750K562ABCF1
TMEM126BENSG00000171204.81162.657101905.87320-0.713006.166705.35030K562AQR
TMEM126BENSG00000171204.8875.970901189.54160-0.441505.940204.51410K562BCLAF1
TMEM126BENSG00000171204.8547.30450819.37460-0.582203.075102.24870K562CPSF6
TMEM126BENSG00000171204.8677.51780902.44440-0.413603.784802.52210K562CSTF2
TMEM126BENSG00000171204.8560.75720850.28410-0.600603.824202.73870K562EFTUD2
TMEM126BENSG00000171204.8556.03050696.37630-0.324702.704001.51490K562EIF2S1
TMEM126BENSG00000171204.81058.229501326.40970-0.325903.419202.63270K562EIF2S2
TMEM126BENSG00000171204.8634.64250910.59320-0.520902.308301.37290K562EIF3D
TMEM126BENSG00000171204.8433.30240596.48920-0.461104.009202.57540K562EIF4B
TMEM126BENSG00000171204.8629.24720835.82830-0.409603.442302.01070K562EXOSC5
TMEM126BENSG00000171204.8968.45120688.827100.491405.922605.08650K562FXR1
TMEM126BENSG00000171204.8543.76170782.34360-0.524802.653701.87430K562GPKOW
TMEM126BENSG00000171204.8817.684501127.91720-0.464004.845103.44150K562HNRNPA1
TMEM126BENSG00000171204.8479.23140755.24720-0.656202.232601.68800K562HNRNPC
TMEM126BENSG00000171204.8954.977201249.09400-0.387304.271303.15280K562HNRNPU
TMEM126BENSG00000171204.8706.51570991.19600-0.488402.484101.52900K562IGF2BP2
TMEM126BENSG00000171204.8435.24850667.91240-0.617803.331902.29800K562KRR1
TMEM126BENSG00000171204.8755.81930938.33770-0.312103.132002.34180K562NSUN2
TMEM126BENSG00000171204.8820.888801063.17040-0.373102.377001.60780K562PCBP3
TMEM126BENSG00000171204.81094.57530798.052100.455703.414102.82010K562PUS1
TMEM126BENSG00000171204.8528.04580743.88160-0.494402.258901.39090K562SF3B1
TMEM126BENSG00000171204.8365.67470501.90970-0.456902.856301.57450K562SLBP
TMEM126BENSG00000171204.8543.24700801.37550-0.560903.159702.07200K562SUPV3L1
TMEM126BENSG00000171204.8664.54710969.31220-0.544602.392701.63880K562TIA1
TMEM126BENSG00000171204.8642.02020863.33030-0.427302.403901.30180K562XRN2
TMEM126BENSG00000171204.81514.492302147.31100-0.503703.635002.62020K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for TMEM126B is not available on ENCORE database.





46 RBPs can affect the splicing of TMEM126B :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SETMEM126BENSG00000171204.8chr11+8534218885342360853396618533973285342730853428520.329000.000000.00000includedHepG2G3BP1
SETMEM126BENSG00000171204.8chr11+8534017585340306853396628533973285342188853423600.113000.001380.02711includedK562SRSF1
SETMEM126BENSG00000171204.8chr11+853421888534236085339648853397328534273085342835-0.321000.000000.00000excludedK562SRSF1
SETMEM126BENSG00000171204.8chr11+853421888534236085339661853397328534273085342852-0.192000.000000.00000excludedK562SF3B4
SETMEM126BENSG00000171204.8chr11+8534017585340306853396628533973285342730853428520.071000.003730.09833includedK562PRPF8
SETMEM126BENSG00000171204.8chr11+853427308534285285339628853397328534512985345323-0.173000.000000.00000excludedK562PRPF8
SETMEM126BENSG00000171204.8chr11+853421888534236085339661853397328534273085342852-0.255000.000000.00031excludedHepG2RBM22
SETMEM126BENSG00000171204.8chr11+853421888534236085339648853397328534273085342835-0.315000.000000.00000excludedHepG2U2AF1
SETMEM126BENSG00000171204.8chr11+853421888534236085339661853397328534273085342852-0.146000.000170.00761excludedK562AKAP8L
SETMEM126BENSG00000171204.8chr11+853421888534236085339648853397328534273085342835-0.143000.000070.01262excludedK562FMR1
SETMEM126BENSG00000171204.8chr11+8534218885342360853396618533973285342730853428520.255000.000040.01474includedHepG2DKC1
SETMEM126BENSG00000171204.8chr11+853421888534236085339648853397328534273085342835-0.236000.000440.00707excludedHepG2U2AF2
SETMEM126BENSG00000171204.8chr11+853421888534236085339661853397328534273085342852-0.221000.000000.00006excludedHepG2AKAP1
SETMEM126BENSG00000171204.8chr11+853421888534236085339661853397328534273085342852-0.191000.000000.00005excludedK562METAP2
SETMEM126BENSG00000171204.8chr11+853427308534285285339628853397328534512985345323-0.135000.000000.00000excludedK562AQR
SETMEM126BENSG00000171204.8chr11+8534017585340306853396368533973285342730853428520.098000.000140.00821includedK562FXR1
SETMEM126BENSG00000171204.8chr11+853421888534236085339648853397328534273085342835-0.167000.000130.01829excludedHepG2SRSF7
SETMEM126BENSG00000171204.8chr11+853421888534236085339661853397328534273085342852-0.230000.000000.00003excludedHepG2DDX3X
SETMEM126BENSG00000171204.8chr11+853401758534030685339662853397328534218885342360-0.078000.000400.07384excludedK562HNRNPA1
SETMEM126BENSG00000171204.8chr11+853401758534030685339662853397328534273085342852-0.057000.001050.07479excludedK562SUPV3L1
SETMEM126BENSG00000171204.8chr11+853427308534285285339628853397328534512985345323-0.067000.000030.00097excludedK562PUS1
SETMEM126BENSG00000171204.8chr11+8534017585340306853396628533973285342188853423600.159000.000100.01025includedHepG2NCBP2
SETMEM126BENSG00000171204.8chr11+8534017585340306853396628533973285342188853423600.217000.000350.08685includedHepG2EFTUD2
SETMEM126BENSG00000171204.8chr11+853401758534030685339662853397328534218885342360-0.097000.000050.07920excludedK562DHX30
SETMEM126BENSG00000171204.8chr11+8534218885342360853396618533973285342730853428520.240000.000870.04575includedHepG2PTBP1
SETMEM126BENSG00000171204.8chr11+8534218885342360853396618533973285342730853428520.308000.000000.00230includedHepG2HNRNPA1
SETMEM126BENSG00000171204.8chr11+853421888534236085339661853397328534273085342852-0.232000.000000.00000excludedK562GPKOW
SETMEM126BENSG00000171204.8chr11+853401758534030685339662853397328534218885342360-0.150000.000620.07773excludedK562LARP4
SETMEM126BENSG00000171204.8chr11+8534017585340306853396628533973285342730853428520.092000.000300.02047includedK562EFTUD2
SETMEM126BENSG00000171204.8chr11+8534218885342360853396488533973285342730853428520.192000.000000.00425includedK562ILF3
SETMEM126BENSG00000171204.8chr11+853401758534030685339636853397328534218885342360-0.098000.000030.04347excludedK562ILF3
SETMEM126BENSG00000171204.8chr11+8534017585340306853396368533973285342730853428520.148000.000040.00324includedHepG2MATR3
SETMEM126BENSG00000171204.8chr11+853421888534236085339661853397328534273085342852-0.205000.000000.00000excludedK562U2AF1
SETMEM126BENSG00000171204.8chr11+8534215985342360853401758534030685342730853428520.119000.001620.09006includedK562HNRNPL
SETMEM126BENSG00000171204.8chr11+853427308534285285339628853397328534512985345323-0.130000.000570.01960excludedHepG2SF3A3
SETMEM126BENSG00000171204.8chr11+853401758534024785339640853397328534273085342852-0.084000.001690.09232excludedK562HNRNPUL1
SETMEM126BENSG00000171204.8chr11+853421888534236085339661853397328534273085342852-0.203000.000000.00147excludedK562SRSF7
SETMEM126BENSG00000171204.8chr11+853421888534236085339661853397328534273085342852-0.156000.000020.00626excludedK562RBM22
SETMEM126BENSG00000171204.8chr11+853421888534236085339661853397328534273085342852-0.162000.000030.00217excludedK562UTP18
SETMEM126BENSG00000171204.8chr11+8534017585340306853396628533973285342730853428520.157000.001110.09222includedHepG2TAF15
SETMEM126BENSG00000171204.8chr11+853421888534236085339648853397328534273085342835-0.222000.000000.00000excludedK562U2AF2
SETMEM126BENSG00000171204.8chr11+8534017585340306853396628533973285342730853428520.121000.000000.00017includedK562TARDBP
SETMEM126BENSG00000171204.8chr11+853427308534285285339628853397328534512985345323-0.061000.002820.08186excludedK562TARDBP
SETMEM126BENSG00000171204.8chr11+853427308534285285339645853397328534512985345323-0.126000.000000.00001excludedK562HNRNPU
SETMEM126BENSG00000171204.8chr11+853421888534236085339661853397328534273085342852-0.148000.000750.02203excludedK562RBM15
SETMEM126BENSG00000171204.8chr11+853421888534236085339661853397328534273085342852-0.130000.000330.04101excludedK562CPSF6
SETMEM126BENSG00000171204.8chr11+8534017585340306853396628533973285342188853423600.153000.000010.00077includedK562SF3B1
SETMEM126BENSG00000171204.8chr11+853421888534236085339661853397328534273085342852-0.184000.000000.00009excludedK562SF3B1
SETMEM126BENSG00000171204.8chr11+8534017585340306853396628533973285342730853428520.229000.000000.00148includedHepG2SMNDC1
SETMEM126BENSG00000171204.8chr11+853427308534285285339628853397328534512985345323-0.155000.001800.06683excludedHepG2HNRNPU
SETMEM126BENSG00000171204.8chr11+8534218885342360853396618533973285342730853428520.211000.000030.01272includedHepG2XRCC6
SETMEM126BENSG00000171204.8chr11+853421888534236085339661853397328534273085342852-0.239000.000030.01152excludedHepG2PRPF4
SETMEM126BENSG00000171204.8chr11+8534218885342360853396618533973285342730853428520.243000.000130.06383includedHepG2SLTM
SETMEM126BENSG00000171204.8chr11+8534017585340306853396368533973285342188853423600.087000.000340.05916includedK562EIF3G
SETMEM126BENSG00000171204.8chr11+8534218885342360853396618533973285342730853428520.180000.000000.00028includedK562PTBP1
SETMEM126BENSG00000171204.8chr11+853421888534236085340175853403068534273085342852-0.151000.002140.07086excludedK562PTBP1
SETMEM126BENSG00000171204.8chr11+853421888534236085339648853397328534273085342835-0.154000.000000.00015excludedK562HNRNPC
A5SSTMEM126BENSG00000171204.8chr11+8534228785342460853422878534236085342730853428520.097000.000030.00481longerK562AGGF1
MXETMEM126BENSG00000171204.8chr11+8534017585340247853421888534236085339640853397328534273085342852-0.191000.000390.035742includedK562LARP4
MXETMEM126BENSG00000171204.8chr11+85340175853403068534218885342360853396368533973285342730853428520.116000.000830.025261includedHepG2MATR3
MXETMEM126BENSG00000171204.8chr11+85340175853402478534218885342360853396408533973285342730853428520.154000.000000.000001includedK562PTBP1
MXETMEM126BENSG00000171204.8chr11+85340175853403068534218885342360853396368533973285342730853428520.194000.000000.000001includedK562PTBP1
MXETMEM126BENSG00000171204.8chr11+85340175853402478534218885342360853396408533973285342730853428520.111000.002740.081981includedHepG2PTBP1
MXETMEM126BENSG00000171204.8chr11+85340175853403068534218885342360853396368533973285342730853428520.128000.001840.038041includedHepG2SRSF1
MXETMEM126BENSG00000171204.8chr11+8534017585340306853421888534238985339636853397328534273085342852-0.167000.000030.037062includedK562ILF3
MXETMEM126BENSG00000171204.8chr11+8534017585340306853421888534236085339636853397328534273085342852-0.121000.000050.042652includedK562ILF3
MXETMEM126BENSG00000171204.8chr11+85340175853402478534218885342360853396408533973285342730853428520.126000.000080.002431includedK562SRSF1
MXETMEM126BENSG00000171204.8chr11+85340175853403068534218885342360853396368533973285342730853428520.182000.000000.000031includedK562SRSF1
MXETMEM126BENSG00000171204.8chr11+85340175853402478534218885342360853396408533973285342730853428520.145000.000020.002501includedK562SF3B1
MXETMEM126BENSG00000171204.8chr11+85340175853403068534218885342360853396368533973285342730853428520.174000.000000.000371includedK562SF3B1
MXETMEM126BENSG00000171204.8chr11+8534017585340306853421888534236085339636853397328534273085342852-0.076000.000600.095572includedK562HNRNPA1
MXETMEM126BENSG00000171204.8chr11+85340175853402478534218885342360853396408533973285342730853428520.110000.000040.002191includedK562TARDBP
MXETMEM126BENSG00000171204.8chr11+85340175853403068534218885342360853396368533973285342730853428520.136000.000010.000381includedK562TARDBP
MXETMEM126BENSG00000171204.8chr11+85340175853402478534218885342360853396408533973285342730853428520.189000.000060.003451includedK562EFTUD2
MXETMEM126BENSG00000171204.8chr11+85340175853403068534218885342360853396368533973285342730853428520.214000.000010.000501includedK562EFTUD2
MXETMEM126BENSG00000171204.8chr11+8534017585340306853421888534236085339636853397328534273085342852-0.179000.018750.088412includedHepG2U2AF2
MXETMEM126BENSG00000171204.8chr11+8534017585340247853421888534236085339640853397328534273085342852-0.205000.002510.038952includedHepG2HNRNPUL1
MXETMEM126BENSG00000171204.8chr11+8534017585340306853421888534236085339636853397328534273085342852-0.227000.000340.008422includedHepG2HNRNPUL1
MXETMEM126BENSG00000171204.8chr11+8534017585340306853421888534236085339636853397328534273085342852-0.079000.000220.011992includedK562SBDS
MXETMEM126BENSG00000171204.8chr11+85340175853403068534218885342360853396368533973285342730853428520.116000.000950.019991includedK562HNRNPC
MXETMEM126BENSG00000171204.8chr11+8534017585340247853421888534236085339640853397328534273085342852-0.074000.000110.007682includedK562HNRNPU
MXETMEM126BENSG00000171204.8chr11+8534017585340306853421888534236085339636853397328534273085342852-0.080000.000180.010372includedK562HNRNPU
MXETMEM126BENSG00000171204.8chr11+8534017585340306853421888534236085339636853397328534273085342852-0.151000.000930.030532includedHepG2HNRNPU
MXETMEM126BENSG00000171204.8chr11+85340175853403428534218885342360853396368533973285342730853428520.088000.000590.073391includedK562EIF3G
MXETMEM126BENSG00000171204.8chr11+85340175853403068534218885342360853396368533973285342730853428520.104000.000150.028901includedK562EIF3G
MXETMEM126BENSG00000171204.8chr11+85340175853403068534218885342360853396368533973285342730853428520.107000.000470.072111includedK562HNRNPM
MXETMEM126BENSG00000171204.8chr11+8534017585340247853421888534236085339640853397328534273085342852-0.104000.000330.014972includedK562DHX30
MXETMEM126BENSG00000171204.8chr11+8534017585340306853421888534236085339636853397328534273085342852-0.107000.000640.025022includedK562DHX30
MXETMEM126BENSG00000171204.8chr11+85340175853403068534218885342360853396368533973285342730853428520.113000.001560.082021includedHepG2G3BP1
MXETMEM126BENSG00000171204.8chr11+85340175853402478534218885342360853396408533973285342730853428520.124000.001530.050931includedHepG2NCBP2
MXETMEM126BENSG00000171204.8chr11+85340175853403068534218885342360853396368533973285342730853428520.178000.000010.001101includedHepG2NCBP2
MXETMEM126BENSG00000171204.8chr11+8534017585340306853421888534236085339636853397328534273085342852-0.134000.000410.055032includedHepG2XRCC6
MXETMEM126BENSG00000171204.8chr11+85340175853403068534218885342360853396368533973285342730853428520.115000.002170.041451includedK562PRPF8
MXETMEM126BENSG00000171204.8chr11+85340175853403068534218885342360853396368533973285342730853428520.195000.000220.024931includedHepG2PRPF8
MXETMEM126BENSG00000171204.8chr11+85340175853403068534218885342360853396368533973285342730853428520.136000.000130.040871includedK562GPKOW

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for TMEM126B is not avaliable on ENCORE database.