SEC62

General Information

Gene Name       : SEC62
Gene ID             : ENSG00000008952.16
Essential Gene : No

Functions

Localization

Domains (AlphaFold: SEC62)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878SEC62ENSG00000008952.1691.9678.2285.09ENCSR000AEF
HepG2SEC62ENSG00000008952.1646.0363.8754.95ENCSR985KAT
K562SEC62ENSG00000008952.1645.2353.0049.11ENCSR000AEO

Assays

3 Released experiments are available on ENCORE database.

Assay TypeExp_NameENCODE IDTarget labelBiosampleStatusLinked AntibodyControlsMethodNote
knockdown followed by RNA-seq SEC62-BGKcLV33-K562SEC62K562Released   CRISPRKD% = 95.7,98.3
knockdown followed by RNA-seq SEC62-BGKcLV33-K562ENCSR008ECNSEC62K562ReleasedENCSR271ZAB   CRISPRKD% = 0.0,0.0
knockdown followed by RNA-seq SEC62-BGHcLV31-HepG2ENCSR094AESSEC62HepG2ReleasedENCSR452TFV   CRISPRKD% = 67.6,58.8






  eCLIP  

No eCLIP experiment available



  Antibody Validation  
  GeneName    Antibody_DCC_ID    Product_ID    Lot_ID    Phosphate    HepG2 Primary Validation    K562 Primary Validation    HepG2 Secondary Validation    K562 Secondary Validation  
SEC62ENCAB490KGNA303-981A1BGKcLV33-39, Released, ENCODE4


  KD RNA-Seq  
  GeneName    Cell_Line    Method    Exp_ID    Control_ID    Sample_reps    Control_reps    KD%    Status    Project    Note  
SEC62K562CRISPRBGKcLV33-33,BGKcLV33-34BGKcLV33-1,BGKcLV33-295.7,98.3ReleasedENCODE4
SEC62K562CRISPRENCSR008ECNENCSR271ZABSEC62-BGKcLV33-39,SEC62-BGKcLV33-40NT-BGKcLV33-1,NT-BGKcLV33-20.0,0.0ReleasedENCODE4
SEC62HepG2CRISPRENCSR094AESENCSR452TFVSEC62-BGHcLV31-35,SEC62-BGHcLV31-36NT-BGHcLV31-1,NT-BGHcLV31-267.6,58.8ReleasedENCODE4


  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela
SEC62Product_ID: A303-981A
Lot_ID: 1
Source: Bethyl Labs
Target Name: SEC62-human		 SEC62-K562-CRISPR-A303-981A.png<br>Caption: Western blot following CRISPR against SEC62 in K562 whole cell lysate using SEC62 specific antibody. Lane 1 is a ladder, lane 2 is K562 non-targeting control knockdown, lane 3 and 4 are two different CRISPR against SEC62. SEC62 protein appears as the green arrow, Beta-actin serves as a control and appears in red arrow.








RNA Targets

  • eCLIP assay for SEC62 is not avaliable on ENCORE database.



Proteins bound to RNA
  • SEC62 RNA is bound by 23 proteins.  







eCLIP assay for SEC62 is not avaliable on ENCORE database.





23 proteins are bound to SEC62 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr3169693400169693504+3'-UTR,CDS3.5268811.19372HepG2BCLAF1
chr3169706063169706149+3'-UTR,CDS,intron-Proximal3.142663.51818HepG2LIN28B
chr3169700555169700640+3'-UTR,CDS4.2002611.65875K562UCHL5
chr3169706104169706157+3'-UTR,CDS,intron-Proximal4.109983.98564K562LIN28B
chr3169693396169693503+3'-UTR,CDS3.2833516.05932K562UCHL5
chr3169700599169700700+3'-UTR,CDS,intron-Proximal4.791376.73315K562TRA2A
chr3169694732169694796+3'-UTR,CDS,intron-Proximal4.0887412.82496HepG2BCLAF1
chr3169712248169712329+3'-UTR4.440083.35973HepG2FUBP3
chr3169694787169694841+3'-UTR,CDS,intron-Proximal3.0774810.18952K562UCHL5
chr3169700675169700700+3'-UTR,CDS,intron-Proximal4.952036.13315HepG2BCLAF1
chr3169700994169701047+3'-UTR,CDS,intron-Proximal4.521614.28644K562PUM1
chr3169700572169700628+3'-UTR,CDS3.594593.95301K562ZNF622
chr3169700496169700546+3'-UTR,CDS3.406385.15776HepG2BCLAF1
chr3169700588169700675+3'-UTR,CDS4.153769.39582HepG2BCLAF1
chr3169710946169711045+3'-UTR,intron-Distal,intron-Proximal3.524115.27876K562IGF2BP1
chr3169693466169693533+3'-UTR,CDS,intron-Proximal4.680265.68502HepG2PRPF8
chr3169693393169693438+3'-UTR,CDS,intron-Proximal4.4165217.30889K562ZNF622
chr3169700591169700700+3'-UTR,CDS,intron-Proximal5.042434.10368HepG2TRA2A
chr3169693445169693509+3'-UTR,CDS,intron-Proximal3.790519.81646HepG2GRWD1
chr3169700500169700572+3'-UTR,CDS3.163693.19733K562ZNF622
chr3169700945169700980+3'-UTR,CDS,intron-Proximal4.581604.55944K562ZNF622
chr3169700985169701042+3'-UTR,CDS,intron-Proximal3.331373.17744HepG2GRWD1
chr3169700948169700990+3'-UTR,CDS,intron-Proximal3.539306.18248K562UCHL5
chr3169700992169701043+3'-UTR,CDS,intron-Proximal3.524008.91541K562UCHL5
chr3169700992169701042+3'-UTR,CDS,intron-Proximal3.926147.65975HepG2BCLAF1
chr3169700676169700700+3'-UTR,CDS,intron-Proximal4.031833.20027K562ZNF622
chr3169712402169712507+3'-UTR3.107523.34495K562IGF2BP1
chr3169700950169700965+3'-UTR,CDS4.450114.34038HepG2BCLAF1
chr3169694748169694839+3'-UTR,CDS3.0178311.29934K562ZNF622
chr3169700640169700701+3'-UTR,CDS,intron-Proximal5.5520610.23513K562UCHL5
chr3169694731169694748+3'-UTR,CDS,intron-Proximal3.564396.14048K562ZNF622
chr3169700948169701042+3'-UTR,CDS,intron-Proximal3.073704.85442K562HLTF
chr3169703634169703693+3'-UTR,CDS,intron-Proximal4.848784.68690HepG2PRPF8
chr3169693463169693505+3'-UTR,CDS,intron-Proximal4.8563712.66167K562ZNF622
chr3169693438169693463+3'-UTR,CDS6.1927918.34180K562ZNF622
chr3169694796169694839+3'-UTR,CDS3.264968.50351HepG2BCLAF1
chr3169684597169684702+5'-UTR,CDS,intron-Proximal4.4694720.15752HepG2PRPF8
chr3169710749169710827+CDS3.862368.38234K562UCHL5
chr3169710716169710836+CDS3.515246.21602K562ZNF622
chr3169710396169710522+CDS3.453428.84022K562SND1
chr3169710620169710716+CDS4.4233612.72422K562ZNF622
chr3169710605169710741+CDS5.1793521.64414K562UCHL5
chr3169710690169710836+CDS3.942654.14811HepG2FXR2
chr3169710600169710720+CDS3.339653.98500HepG2SND1
chr3169710736169710832+CDS3.761635.98815HepG2G3BP1
chr3169710642169710739+CDS3.658839.08790HepG2BCLAF1
chr3169693535169693616+intron-Distal,intron-Proximal3.911973.20552HepG2KHSRP
chr3169684760169684812+intron-Distal4.956588.61093K562CSTF2T
chr3169684807169684882+intron-Distal3.763383.03048HepG2GTF2F1
chr3169684757169684808+intron-Distal3.599644.35431HepG2PRPF4
chr3169684756169684800+intron-Distal3.550786.14554K562DROSHA
chr3169684760169684816+intron-Distal4.263573.48173K562GTF2F1
chr3169693236169693290+intron-Distal4.359093.45799HepG2U2AF2
chr3169684757169684873+intron-Distal3.681003.19036K562XRN2
chr3169685644169685694+intron-Distal3.849403.21003K562U2AF2
chr3169684812169684897+intron-Distal4.898086.64314K562CSTF2T
chr3169684808169684869+intron-Distal3.387284.59965HepG2PRPF4
chr3169684760169684808+intron-Distal4.733435.74291HepG2FAM120A
chr3169685603169685724+intron-Distal3.947864.79983HepG2U2AF2
chr3169684754169684806+intron-Distal4.056836.49249HepG2EFTUD2
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for SEC62 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for SEC62 is not available on ENCORE database.

  • 92 RBPs can affect the levels of SEC62.  








The Knockdown/knockout RNA-Seq assay for SEC62 is not available on ENCORE database.





92 RBPs can affect the gene expression of SEC62 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
SEC62ENSG00000008952.122359.146303388.36680-0.522305.157603.91210HepG2ABCF1
SEC62ENSG00000008952.123505.317302871.709600.287504.419003.68580HepG2ACO1
SEC62ENSG00000008952.123586.299904494.55220-0.325701.786601.34920HepG2AKAP1
SEC62ENSG00000008952.122126.663702885.50850-0.440206.151405.04990HepG2AKAP8L
SEC62ENSG00000008952.124368.240903615.562200.272703.513902.75650HepG2AUH
SEC62ENSG00000008952.122249.901501829.665900.298202.181901.38200HepG2BCLAF1
SEC62ENSG00000008952.123647.698802660.091400.455406.944005.79340HepG2CALR
SEC62ENSG00000008952.122443.821103533.26640-0.531904.403203.43910HepG2CIRBP
SEC62ENSG00000008952.121770.059602176.36630-0.298103.459402.31980HepG2YBX3
SEC62ENSG00000008952.122735.088403414.83780-0.320207.421606.29260HepG2DAZAP1
SEC62ENSG00000008952.121966.509302656.08960-0.433707.245306.00380HepG2DDX19B
SEC62ENSG00000008952.123391.459604305.74580-0.344401.999001.45860HepG2DDX3X
SEC62ENSG00000008952.122160.116102747.54330-0.347005.143804.27240HepG2DKC1
SEC62ENSG00000008952.121755.649102137.04730-0.283603.310202.54570HepG2DNAJC21
SEC62ENSG00000008952.121753.071702118.14940-0.272904.362703.57750HepG2DNAJC2
SEC62ENSG00000008952.122800.826102081.272000.428302.933801.78850HepG2AGO1
SEC62ENSG00000008952.123010.467503929.80690-0.384502.537501.92440HepG2EIF4A3
SEC62ENSG00000008952.122131.911101723.041900.307102.632801.39290HepG2FKBP4
SEC62ENSG00000008952.122611.952003963.96760-0.601805.614804.65090HepG2FXR1
SEC62ENSG00000008952.122605.836703677.70980-0.497103.701202.93550HepG2G3BP1
SEC62ENSG00000008952.123089.314303903.64360-0.337502.370701.54980HepG2G3BP2
SEC62ENSG00000008952.121035.866601678.98600-0.696808.445006.92040HepG2GEMIN5
SEC62ENSG00000008952.123933.079302735.766600.523602.807401.42770HepG2HLTF
SEC62ENSG00000008952.121438.668102157.52050-0.584608.222207.19410HepG2HNRNPA1
SEC62ENSG00000008952.122801.140903722.73360-0.410303.523702.74050HepG2HNRNPK
SEC62ENSG00000008952.122557.088403110.76520-0.282805.989405.02940HepG2HNRNPL
SEC62ENSG00000008952.121684.055802360.98460-0.487406.283304.92970HepG2HNRNPM
SEC62ENSG00000008952.122049.404702383.96810-0.218202.610502.02250HepG2HNRNPU
SEC62ENSG00000008952.122072.837303553.73900-0.777704.298502.75730HepG2HSPD1
SEC62ENSG00000008952.122134.019502618.79880-0.295302.816802.08580HepG2IGF2BP1
SEC62ENSG00000008952.122368.060203738.50680-0.658805.954505.00050HepG2IGF2BP2
SEC62ENSG00000008952.122659.191803759.93400-0.499703.593202.42960HepG2KHSRP
SEC62ENSG00000008952.122950.223103965.34690-0.426603.374202.64910HepG2MAGOH
SEC62ENSG00000008952.123007.213304081.78090-0.440803.124902.45420HepG2NCBP2
SEC62ENSG00000008952.122861.287202359.731500.277903.970602.97570HepG2PARN
SEC62ENSG00000008952.122968.569403622.61240-0.287304.643103.89110HepG2PCBP1
SEC62ENSG00000008952.122565.343603686.18310-0.5230012.9612011.95110HepG2PTBP1
SEC62ENSG00000008952.121728.591602925.07650-0.7589018.0440016.71780HepG2PUS1
SEC62ENSG00000008952.123200.301703992.14310-0.319004.291803.53870HepG2QKI
SEC62ENSG00000008952.124327.515202609.427400.729705.028304.09160HepG2RAVER1
SEC62ENSG00000008952.124304.857503623.158300.248602.329401.70530HepG2RBM25
SEC62ENSG00000008952.122178.012504102.33500-0.9134037.9632036.46230HepG2NELFE
SEC62ENSG00000008952.122698.910903820.82710-0.5015012.8670011.68320HepG2RECQL
SEC62ENSG00000008952.121320.802501834.74880-0.474205.344504.52300HepG2RPS19
SEC62ENSG00000008952.121567.277803563.25090-1.1849015.9635014.26810HepG2SF3A3
SEC62ENSG00000008952.122758.836003837.72160-0.4762011.6064010.52590HepG2SF3B4
SEC62ENSG00000008952.121803.492902475.82560-0.4571012.1691010.96930HepG2SMN1
SEC62ENSG00000008952.124292.893702949.869400.541203.595602.70080HepG2SNRNP70
SEC62ENSG00000008952.122978.250103918.69720-0.395905.304404.67230HepG2SRFBP1
SEC62ENSG00000008952.123286.949004005.77940-0.285305.183904.58830HepG2SRSF1
SEC62ENSG00000008952.123639.089103191.240000.189402.118001.56180HepG2SRSF5
SEC62ENSG00000008952.123918.804803258.939800.265904.567403.89150HepG2SRSF9
SEC62ENSG00000008952.123649.446002438.478000.581604.211202.71500HepG2SUB1
SEC62ENSG00000008952.123204.012503629.43930-0.179902.776402.15390HepG2SUCLG1
SEC62ENSG00000008952.122434.893203600.63090-0.5644010.316209.34310HepG2TAF15
SEC62ENSG00000008952.121263.561102316.50400-0.8745021.2805020.13520HepG2TIAL1
SEC62ENSG00000008952.121669.299602337.17580-0.4855010.146709.17120HepG2TRIM56
SEC62ENSG00000008952.123754.028002927.147200.358803.303302.62190HepG2U2AF1
SEC62ENSG00000008952.122709.824103160.06000-0.221803.186102.44680HepG2UPF1
SEC62ENSG00000008952.121752.454303050.91190-0.7999029.4872027.84790HepG2UTP3
SEC62ENSG00000008952.123584.268102565.382100.482403.122901.77650HepG2XRCC5
SEC62ENSG00000008952.121346.395702028.58500-0.591403.067702.30530HepG2XRN2
SEC62ENSG00000008952.122356.161402016.902700.224203.149502.44080HepG2ZC3H8
SEC62ENSG00000008952.121606.128103475.45940-1.1136071.5785069.77940HepG2ZNF622
SEC62ENSG00000008952.123488.951202606.423100.420602.678501.40720HepG2ZRANB2
SEC62ENSG00000008952.121714.051701385.226200.307202.558001.42800K562AARS
SEC62ENSG00000008952.123063.585702623.854200.223402.420201.57030K562ATP5C1
SEC62ENSG00000008952.122818.437003283.01820-0.220102.406101.38210K562CPEB4
SEC62ENSG00000008952.121991.422302469.50320-0.310403.073102.24720K562CPSF6
SEC62ENSG00000008952.121113.847401364.26230-0.292602.692101.64890K562CSTF2
SEC62ENSG00000008952.125854.187204717.847300.311204.198002.98840K562CELF1
SEC62ENSG00000008952.121392.764901761.13110-0.338603.234702.10170K562DDX3X
SEC62ENSG00000008952.124017.029503397.502700.241603.568802.84100K562DDX47
SEC62ENSG00000008952.121856.652302460.48090-0.406203.073302.32230K562EIF2S2
SEC62ENSG00000008952.121383.192601656.94730-0.260502.444501.38050K562EIF4B
SEC62ENSG00000008952.122115.042402692.96680-0.348503.260202.33660K562FIP1L1
SEC62ENSG00000008952.121935.171902512.59300-0.376703.410002.45750K562FMR1
SEC62ENSG00000008952.122959.084402191.605400.433102.932502.20180K562G3BP2
SEC62ENSG00000008952.122224.072503279.19530-0.560103.917803.02200K562GRSF1
SEC62ENSG00000008952.121136.496801516.07310-0.415704.097203.38600K562HNRNPC
SEC62ENSG00000008952.122571.515403651.24620-0.505806.367905.17470K562HSPD1
SEC62ENSG00000008952.123491.171502653.886600.395504.630503.51640K562KIF1C
SEC62ENSG00000008952.121879.397102301.46000-0.292302.588901.74640K562METAP2
SEC62ENSG00000008952.121845.073102199.42330-0.253403.260102.38470K562MTPAP
SEC62ENSG00000008952.125199.638604197.040100.308902.848201.33790K562NOL12
SEC62ENSG00000008952.122126.228002443.78800-0.200803.087602.30310K562NSUN2
SEC62ENSG00000008952.122305.355103056.89070-0.407104.184203.14700K562PPIG
SEC62ENSG00000008952.121772.959401449.558400.290402.124801.46380K562PRPF8
SEC62ENSG00000008952.121053.223201359.27460-0.368002.932401.99600K562PSIP1
SEC62ENSG00000008952.122029.152102466.62360-0.281702.666002.01220K562PTBP1
SEC62ENSG00000008952.125224.899904186.500100.319602.952702.10860K562PUF60
SEC62ENSG00000008952.123208.370902480.026600.371403.271702.68920K562PUS1
SEC62ENSG00000008952.123165.244202416.411300.389405.983805.13860K562RBM15
SEC62ENSG00000008952.121850.399702365.43800-0.354303.231302.31710K562RBM22
SEC62ENSG00000008952.121824.813002411.34860-0.402106.156404.97860K562SF3A3
SEC62ENSG00000008952.121794.162602279.50370-0.345403.951602.92430K562SF3B4
SEC62ENSG00000008952.12893.176001175.46210-0.396203.168102.05220K562SRFBP1
SEC62ENSG00000008952.122858.377102418.064100.241202.163701.53010K562SRSF1
SEC62ENSG00000008952.121854.629102447.34510-0.400103.661602.84320K562TARDBP
SEC62ENSG00000008952.121845.815202360.71280-0.355003.909602.91370K562TIA1
SEC62ENSG00000008952.12988.891301307.42040-0.402802.865001.91320K562TIAL1
SEC62ENSG00000008952.121011.615301388.72950-0.457104.383403.13100K562TRIM56
SEC62ENSG00000008952.122847.324502125.074600.422002.576801.52540K562U2AF1
SEC62ENSG00000008952.122831.486902194.511600.367604.676803.63870K562U2AF2
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for SEC62 is not available on ENCORE database.





4 RBPs can affect the splicing of SEC62 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SESEC62ENSG00000008952.12chr3+169703592169703653169700865169701041169706027169706147-0.172000.000000.00000excludedK562AQR
SESEC62ENSG00000008952.12chr3+169706027169706147169700948169701041169710381169710623-0.172000.000270.00558excludedK562PUS1
SESEC62ENSG00000008952.12chr3+169706027169706147169700948169701041169710381169710623-0.151000.000770.02808excludedK562UTP18
MXESEC62ENSG00000008952.12chr3+1696933951696934361696947331696948391696845951696846461697004941697006990.082000.000000.000171includedK562DROSHA
MXESEC62ENSG00000008952.12chr3+1697060271697061471697103811697108891697009481697010411697114421697116190.623000.000000.000001includedK562AQR

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for SEC62 is not avaliable on ENCORE database.