TDP1

General Information

Gene Name       : TDP1
Gene ID             : ENSG00000042088.13
Essential Gene : No

Functions

Localization

Domains (AlphaFold: TDP1)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878TDP1ENSG00000042088.1338.7136.6437.67ENCSR000AEF
HepG2TDP1ENSG00000042088.1320.0624.8322.45ENCSR985KAT
K562TDP1ENSG00000042088.1319.2821.7520.52ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for TDP1 is not avaliable on ENCORE database.



Proteins bound to RNA
  • TDP1 RNA is bound by 9 proteins.  







eCLIP assay for TDP1 is not avaliable on ENCORE database.





9 proteins are bound to TDP1 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr149051096290511065+3'-UTR6.143997.94582K562PUM2
chr149044695290447012+5'-UTR,CDS,intron-Proximal3.217263.95099HepG2PRPF8
chr149043371190433809+5'-UTR,CDS,intron-Proximal5.146938.77485HepG2PRPF8
chr149043372690433766+5'-UTR,CDS3.334643.34848HepG2PPIG
chr149044215490442249+5'-UTR,CDS,intron-Distal,intron-Proximal4.331156.99120K562AQR
chr149048670990486757+intron-Distal5.517119.42242HepG2PCBP2
chr149050124090501295+intron-Distal5.238568.20307HepG2QKI
chr149048670890486771+intron-Distal3.198285.71552K562ILF3
chr149048696890487044+intron-Distal4.849725.88499HepG2DDX59
chr149050143390501491+intron-Distal5.8140813.44723HepG2QKI
chr149050149190501542+intron-Distal5.163297.97897HepG2QKI
chr149048753390487622+intron-Distal3.444533.59395HepG2PTBP1
chr149048697790487042+intron-Distal5.621419.83537HepG2PCBP2
chr149050122190501391+intron-Distal5.256107.15244K562QKI
chr149050134290501403+intron-Distal4.753574.05848HepG2QKI
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for TDP1 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for TDP1 is not available on ENCORE database.

  • 106 RBPs can affect the levels of TDP1.  








The Knockdown/knockout RNA-Seq assay for TDP1 is not available on ENCORE database.





106 RBPs can affect the gene expression of TDP1 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
TDP1ENSG00000042088.9350.06080516.83250-0.562105.394404.35580HepG2AKAP8L
TDP1ENSG00000042088.9296.42870437.41310-0.561302.810002.02070HepG2ASCC1
TDP1ENSG00000042088.9383.64800597.24460-0.638505.069003.22610HepG2ATP5C1
TDP1ENSG00000042088.9516.14150767.83730-0.573007.111506.09260HepG2AUH
TDP1ENSG00000042088.9337.09500491.54050-0.544203.018102.03540HepG2BCCIP
TDP1ENSG00000042088.9273.39380427.08700-0.643504.084903.01210HepG2BCLAF1
TDP1ENSG00000042088.9232.71490460.24300-0.983809.314508.29810HepG2BOP1
TDP1ENSG00000042088.9360.21390495.83240-0.461002.898101.63790HepG2BUD13
TDP1ENSG00000042088.9348.59960549.87460-0.657506.038404.95580HepG2CALR
TDP1ENSG00000042088.9275.80720415.56510-0.591402.950802.15310HepG2CIRBP
TDP1ENSG00000042088.9268.51030514.31380-0.9377013.6749012.42850HepG2CKAP4
TDP1ENSG00000042088.9253.23710422.51500-0.738505.195504.27980HepG2CPSF6
TDP1ENSG00000042088.9409.74500545.01380-0.411602.438101.40440HepG2CPSF7
TDP1ENSG00000042088.9410.45090775.46630-0.9179015.2017013.93430HepG2CELF1
TDP1ENSG00000042088.9603.66800833.81230-0.466006.115005.07370HepG2DAZAP1
TDP1ENSG00000042088.9304.81220476.32070-0.644003.148302.42850HepG2DDX21
TDP1ENSG00000042088.9398.47820544.15160-0.449502.800901.78290HepG2DDX5
TDP1ENSG00000042088.9353.88450492.12560-0.475703.764302.99770HepG2DKC1
TDP1ENSG00000042088.9300.75520500.39550-0.734507.675906.55150HepG2DNAJC21
TDP1ENSG00000042088.9366.90330495.96480-0.434803.828303.08580HepG2DNAJC2
TDP1ENSG00000042088.9279.40360438.25910-0.649403.480302.23000HepG2AGO1
TDP1ENSG00000042088.9233.67050418.21150-0.839805.474904.65700HepG2EIF2S1
TDP1ENSG00000042088.9324.77230449.93780-0.470301.917001.33730HepG2EIF4B
TDP1ENSG00000042088.9637.29990822.61080-0.368203.503202.57810HepG2EIF4G1
TDP1ENSG00000042088.9534.11610788.00780-0.561104.769003.71710HepG2EIF4G2
TDP1ENSG00000042088.9653.75660881.56690-0.431304.628403.88730HepG2ETF1
TDP1ENSG00000042088.9247.90460355.33300-0.519402.869602.06890HepG2FUBP3
TDP1ENSG00000042088.9623.07640466.200200.418402.430601.78050HepG2FXR1
TDP1ENSG00000042088.9266.24140432.55810-0.700204.301003.48090HepG2G3BP1
TDP1ENSG00000042088.9313.69380478.91740-0.610403.690802.96020HepG2GPKOW
TDP1ENSG00000042088.9383.69110491.10910-0.356102.572101.62530HepG2HDGF
TDP1ENSG00000042088.9311.08520569.78730-0.873104.975803.06840HepG2HLTF
TDP1ENSG00000042088.9281.71450505.18930-0.842607.504206.51690HepG2HNRNPA1
TDP1ENSG00000042088.9556.12360766.29950-0.462504.667003.50550HepG2HNRNPA2B1
TDP1ENSG00000042088.9345.94770561.92570-0.699805.709704.74130HepG2HNRNPC
TDP1ENSG00000042088.9387.76350620.25570-0.677708.298707.14190HepG2HNRNPF
TDP1ENSG00000042088.9524.51780759.53790-0.534106.999705.97300HepG2HNRNPL
TDP1ENSG00000042088.9238.11110457.04300-0.940707.849906.85060HepG2HNRNPLL
TDP1ENSG00000042088.9220.46870558.21080-1.3402024.8681023.19760HepG2HNRNPU
TDP1ENSG00000042088.9416.38250610.77470-0.552704.907503.96890HepG2IGF2BP1
TDP1ENSG00000042088.9230.17880439.71750-0.933806.035205.07560HepG2IGF2BP2
TDP1ENSG00000042088.9358.58930570.19460-0.669108.732807.50180HepG2ILF2
TDP1ENSG00000042088.9375.10030470.23260-0.326102.294101.36340HepG2KIF1C
TDP1ENSG00000042088.9445.47420830.83430-0.899208.076006.64800HepG2LARP4
TDP1ENSG00000042088.9384.14380509.97160-0.408802.454801.39110HepG2LARP7
TDP1ENSG00000042088.9389.22000535.41580-0.460102.954301.69980HepG2LIN28B
TDP1ENSG00000042088.9294.54010461.10900-0.646604.949103.04250HepG2NIP7
TDP1ENSG00000042088.9620.40480826.80680-0.414303.800902.90610HepG2NOL12
TDP1ENSG00000042088.9290.22970443.85450-0.612902.602401.54450HepG2NONO
TDP1ENSG00000042088.9282.70860405.28230-0.519602.857302.09610HepG2NSUN2
TDP1ENSG00000042088.9203.48190427.63640-1.071507.399006.23080HepG2PABPC4
TDP1ENSG00000042088.9436.04360552.53820-0.341602.449001.64760HepG2PARN
TDP1ENSG00000042088.9365.67230470.53490-0.363802.360301.79020HepG2PCBP1
TDP1ENSG00000042088.9282.43540562.49260-0.993907.529805.90010HepG2PCBP2
TDP1ENSG00000042088.9414.57930553.43020-0.416803.325202.48440HepG2PRPF4
TDP1ENSG00000042088.9162.02520372.76150-1.2020010.154108.72850HepG2PRPF8
TDP1ENSG00000042088.9451.05650789.26070-0.807209.649508.62840HepG2PUF60
TDP1ENSG00000042088.9511.42080837.83640-0.7122012.7176011.64330HepG2PUM1
TDP1ENSG00000042088.9437.72110837.22360-0.9356014.1866012.74380HepG2PUM2
TDP1ENSG00000042088.9423.27410523.92550-0.307802.164001.60280HepG2PUS1
TDP1ENSG00000042088.9249.20970470.60270-0.917108.904507.74720HepG2RBM25
TDP1ENSG00000042088.9453.73510614.94910-0.438602.760501.76990HepG2RBM27
TDP1ENSG00000042088.9628.57140496.319200.340702.642502.03820HepG2RECQL
TDP1ENSG00000042088.9419.59680668.16870-0.671206.212705.24610HepG2RPLP0
TDP1ENSG00000042088.9306.50530533.26600-0.798904.931103.68860HepG2RPS10
TDP1ENSG00000042088.9255.25590405.32050-0.667104.785904.00200HepG2RPS19
TDP1ENSG00000042088.9399.86700567.13540-0.504203.367302.48480HepG2RPS2
TDP1ENSG00000042088.9176.88800368.73200-1.059707.794006.55840HepG2RRP9
TDP1ENSG00000042088.9275.03230406.80920-0.564803.301202.26980HepG2SERBP1
TDP1ENSG00000042088.9329.01670452.36140-0.459302.693701.99680HepG2SF3B1
TDP1ENSG00000042088.9366.92800498.45870-0.442003.156002.52950HepG2SF3B4
TDP1ENSG00000042088.9476.52120756.78080-0.667309.928308.72790HepG2SLBP
TDP1ENSG00000042088.9379.90940553.74160-0.543602.960301.96740HepG2SMNDC1
TDP1ENSG00000042088.9281.38950503.33880-0.839004.854903.80670HepG2SNRNP70
TDP1ENSG00000042088.9541.72300832.22670-0.619408.765808.01150HepG2SRFBP1
TDP1ENSG00000042088.9503.37670779.28160-0.630508.327107.31680HepG2SRSF5
TDP1ENSG00000042088.9347.82000609.38110-0.8090011.200509.96290HepG2SRSF7
TDP1ENSG00000042088.9252.81640423.31090-0.743607.337606.51610HepG2SRSF9
TDP1ENSG00000042088.9358.02830722.57820-1.0131018.4671017.39230HepG2SSB
TDP1ENSG00000042088.9312.02590446.36920-0.516602.698801.47480HepG2STAU1
TDP1ENSG00000042088.9336.51570507.23540-0.592002.647801.47400HepG2SUB1
TDP1ENSG00000042088.9710.28910886.25640-0.319303.154502.49890HepG2SUCLG1
TDP1ENSG00000042088.9308.44370451.25250-0.548903.943902.83350HepG2SUPT6H
TDP1ENSG00000042088.9187.30770481.09750-1.3609013.3341012.03460HepG2SUPV3L1
TDP1ENSG00000042088.9275.40680445.57140-0.694105.010804.07740HepG2TARDBP
TDP1ENSG00000042088.9213.11910322.45150-0.597403.056402.01250HepG2TFIP11
TDP1ENSG00000042088.9243.37930542.42110-1.1562015.8697014.84960HepG2TIAL1
TDP1ENSG00000042088.9315.43320547.25390-0.7949010.398609.40970HepG2TRIM56
TDP1ENSG00000042088.9540.65630771.07650-0.512204.484603.34120HepG2TUFM
TDP1ENSG00000042088.9552.84880816.17380-0.562003.603102.64180HepG2UBE2L3
TDP1ENSG00000042088.9205.53100284.18640-0.467502.149001.47970HepG2UCHL5
TDP1ENSG00000042088.9286.65190494.63440-0.787109.375308.22060HepG2UPF1
TDP1ENSG00000042088.9306.42260544.00360-0.8281011.8913010.95450HepG2ZNF622
TDP1ENSG00000042088.9230.23770542.37090-1.2362011.701208.94990HepG2ZRANB2
TDP1ENSG00000042088.9608.28880777.20700-0.353502.334901.73350K562AKAP8L
TDP1ENSG00000042088.9640.282701008.93540-0.656106.801605.94750K562AQR
TDP1ENSG00000042088.9511.80250714.66830-0.481703.726302.22940K562CIRBP
TDP1ENSG00000042088.91109.954501683.67440-0.601109.405107.65670K562CELF1
TDP1ENSG00000042088.9857.512101122.52960-0.388504.444303.64440K562DDX47
TDP1ENSG00000042088.9341.26460561.73820-0.719005.943004.56820K562EFTUD2
TDP1ENSG00000042088.9432.33250601.45660-0.476302.642201.63330K562EIF3D
TDP1ENSG00000042088.9423.28730577.08290-0.447102.640601.74850K562FTO
TDP1ENSG00000042088.9405.22340563.17960-0.474902.774801.35550K562GEMIN5
TDP1ENSG00000042088.9441.35480638.80270-0.533404.134403.16890K562GPKOW
TDP1ENSG00000042088.9826.172401134.69340-0.457804.415403.46470K562GRSF1
TDP1ENSG00000042088.9504.88130734.81190-0.541405.117403.67280K562HNRNPA1
TDP1ENSG00000042088.9313.18070732.23420-1.2253011.4630010.32000K562HNRNPC
TDP1ENSG00000042088.9414.35720813.80420-0.9738016.6222014.54960K562HNRNPU
TDP1ENSG00000042088.9366.88140545.50370-0.572303.043102.05960K562KRR1
TDP1ENSG00000042088.9763.09890919.42170-0.268902.701301.96330K562NSUN2
TDP1ENSG00000042088.9504.59910656.48470-0.379602.201101.40230K562PSIP1
TDP1ENSG00000042088.91228.755901556.91170-0.341503.942002.79130K562PUM2
TDP1ENSG00000042088.9653.51180907.18320-0.473205.297304.19530K562SF3A3
TDP1ENSG00000042088.9441.65880607.58770-0.460202.572801.63710K562SF3B1
TDP1ENSG00000042088.9408.19770573.42240-0.490304.149503.09690K562SF3B4
TDP1ENSG00000042088.9806.36910643.867100.324602.399501.63540K562SYNCRIP
TDP1ENSG00000042088.9467.65540675.53380-0.530604.056903.19380K562TARDBP
TDP1ENSG00000042088.9439.74990631.45180-0.522003.247402.22730K562TIAL1
TDP1ENSG00000042088.9512.88550670.62090-0.386902.260401.41860K562TRIM56
TDP1ENSG00000042088.9804.09680974.87960-0.277902.573901.88010K562UPF1
TDP1ENSG00000042088.9644.34210834.17820-0.372502.910202.01240K562WDR3
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for TDP1 is not available on ENCORE database.





6 RBPs can affect the splicing of TDP1 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SETDP1ENSG00000042088.9chr14+904229219042314490422298904223149042945190430017-0.535000.001240.08829excludedHepG2G3BP1
SETDP1ENSG00000042088.9chr14+9045332990453386904514329045155490455248904554340.054000.006650.05872includedK562AQR
SETDP1ENSG00000042088.9chr14+904856599048576290459719904598279050941390509653-0.096000.007660.06580excludedK562AQR
SETDP1ENSG00000042088.9chr14+904421249044215990437518904376159044688390446936-0.090000.002180.02359excludedK562AQR
SETDP1ENSG00000042088.9chr14+9042292190423144904222989042231490429451904300170.327000.001540.03617includedHepG2SRSF1
SETDP1ENSG00000042088.9chr14+9042292190423144904222989042231490429451904300170.501000.000060.00460includedHepG2SF3B4
MXETDP1ENSG00000042088.9chr14+90446883904469769045085990451027904421249044215990451475904515540.099000.000000.000151includedK562DROSHA
MXETDP1ENSG00000042088.9chr14+90446883904469769045085990451027904375189043761590451475904515540.076000.006930.047071includedK562AQR
MXETDP1ENSG00000042088.9chr14+9044212490442159904468839044697690437518904376159045085990451027-0.155000.000300.007752includedHepG2HNRNPUL1

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for TDP1 is not avaliable on ENCORE database.