ELAC2

General Information

Gene Name       : ELAC2
Gene ID             : ENSG00000006744.18
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: ELAC2)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878ELAC2ENSG00000006744.1854.3257.1555.73ENCSR000AEF
HepG2ELAC2ENSG00000006744.1860.0554.3957.22ENCSR985KAT
K562ELAC2ENSG00000006744.1862.6364.9963.81ENCSR000AEO

Assays

3 Released experiments are available on ENCORE database.

Assay TypeExp_NameENCODE IDTarget labelBiosampleStatusLinked AntibodyControlsMethodNote
eCLIPeCLIP: 4224ENCSR440MSYELAC2K562ReleasedENCAB519QXKENCSR545KBT  
knockdown followed by RNA-seq ELAC2-BGKcLV23-K562ENCSR715GSXELAC2K562ReleasedENCSR877JEM   CRISPRKD% = 86.3,83.5
knockdown followed by RNA-seq ELAC2-BGHcLV24-HepG2ENCSR511EKJELAC2HepG2ReleasedENCSR671FDZ   CRISPRKD% = 81.0,83.0






  eCLIP  
  RBP    Exp_UID    Cell_Line    ENCODE_ACCESSION    Control_ENCODE_ACCESSION    ENCODE_Antibody_ID    Antibody    Lot_num    Status    Project  
ELAC24224K562ENCSR440MSYENCSR545KBTENCAB519QXKPA5-78553UK2881508ReleasedENCODE4


  Antibody Validation  
  GeneName    Antibody_DCC_ID    Product_ID    Lot_ID    Phosphate    HepG2 Primary Validation    K562 Primary Validation    HepG2 Secondary Validation    K562 Secondary Validation  
ELAC2ENCAB519QXKPA5-78553UK2881508BGHcLV24-31, Released, ENCODE4BGKcLV23-41, Released, ENCODE4


  KD RNA-Seq  
  GeneName    Cell_Line    Method    Exp_ID    Control_ID    Sample_reps    Control_reps    KD%    Status    Project    Note  
ELAC2K562CRISPRENCSR715GSXENCSR877JEMELAC2-BGKcLV23-41,ELAC2-BGKcLV23-42NT-BGKcLV23-1,NT-BGKcLV23-286.3,83.5ReleasedENCODE4
ELAC2K562CRISPRBGKcLV23-43,BGKcLV23-44BGKcLV23-1,BGKcLV23-238.6,63.1NotSatisfiedENCODE4
ELAC2HepG2CRISPRENCSR511EKJENCSR671FDZELAC2-BGHcLV24-31,ELAC2-BGHcLV24-32NT-BGHcLV24-1,NT-BGHcLV24-281.0,83.0ReleasedENCODE4


  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela
ELAC2Product_ID: PA5-78553
Lot_ID: UK2881508
Source: Thermo Fisher
Target Name: ELAC2-human		 ELAC2-HEPG2-CRISPR-PA5-78553.png<br>Caption: Western blot following CRISPR against ELAC2 in HepG2 whole cell lysate using ELAC2 specific antibody. Lane 1 is a ladder, lane 2 is HepG2 non-targeting control knockdown, lane 3 and 4 are two different CRISPR against ELAC2. ELAC2 protein appears as the green arrow, GAPDH serves as a control and appears in red arrow.
 ELAC2-k562-CRISPR-PA5-78553.png<br>Caption: Western blot following CRISPR against ELAC2 in K562 whole cell lysate using ELAC2 specific antibody. Lane 1 is a ladder, lane 2 is K562 non-targeting control knockdown, lane 3 and 4 are two different CRISPR against ELAC2. ELAC2 protein appears as the green arrow, GAPDH serves as a control and appears in red arrow.








RNA Targets

  • eCLIP assay for ELAC2 is not avaliable on ENCORE database.



Proteins bound to RNA
  • ELAC2 RNA is bound by 13 proteins.  







eCLIP assay for ELAC2 is not avaliable on ENCORE database.





13 proteins are bound to ELAC2 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr171291500512915089-3'-UTR,CDS,intron-Distal,intron-Proximal5.049217.95724HepG2PPIG
chr171290347012903546-3'-UTR,CDS,intron-Distal,intron-Proximal5.111717.48032HepG2G3BP1
chr171290347212903534-3'-UTR,CDS,intron-Distal,intron-Proximal3.142984.51003HepG2PPIG
chr171290347212903553-3'-UTR,CDS,intron-Distal,intron-Proximal3.540584.74268K562UCHL5
chr171291505312915084-3'-UTR,CDS,intron-Distal,intron-Proximal3.495445.11155K562YBX3
chr171292114412921290-5'-UTR,CDS,intron-Distal,intron-Proximal3.986066.59200K562DDX3X
chr171290555312905625-5'-UTR,CDS,intron-Distal,intron-Proximal3.999845.34978HepG2PRPF8
chr171289831612898359-CDS,intron-Distal4.616744.67689HepG2PPIG
chr171291394012913988-CDS,intron-Distal3.313733.59112HepG2PPIG
chr171289818012898252-CDS,intron-Distal,intron-Proximal3.309433.75245K562BUD13
chr171290923712909289-CDS,intron-Distal,intron-Proximal3.384415.30777HepG2PPIG
chr171289814812898261-CDS,intron-Distal,intron-Proximal3.790485.62957HepG2BUD13
chr171289615412896312-CDS,intron-Distal3.691216.03511HepG2G3BP1
chr171290918912909278-CDS,intron-Distal,intron-Proximal3.892514.16174HepG2PRPF8
chr171289701712897073-CDS,intron-Distal3.509894.22917HepG2PPIG
chr171290833312908405-CDS,intron-Distal3.101484.39623HepG2PPIG
chr171289619112896330-CDS,intron-Distal3.896653.67596K562GRWD1
chr171290837712908473-CDS,intron-Distal,intron-Proximal4.414713.98315HepG2SF3B4
chr171289902612899116-CDS,intron-Distal3.589444.86632HepG2G3BP1
chr171292121812921263-CDS,intron-Distal5.574575.29846HepG2DDX3X
chr171290908812909143-CDS,intron-Distal,intron-Proximal3.734403.11149HepG2G3BP1
chr171289808012898134-CDS,intron-Distal,intron-Proximal3.223223.24162HepG2G3BP1
chr171289981312899868-CDS,intron-Distal,intron-Proximal4.721835.17615K562AQR
chr171289982112899878-CDS,intron-Distal,intron-Proximal4.022746.23016HepG2PRPF8
chr171289807512898123-CDS,intron-Distal,intron-Proximal3.939933.86355HepG2PPIG
chr171290178012901826-CDS,intron-Distal,intron-Proximal4.170634.25741HepG2G3BP1
chr171289822812898291-CDS,intron-Distal,intron-Proximal4.035514.45914HepG2PRPF8
chr171290826312908328-CDS,intron-Distal,intron-Proximal3.368936.47263K562EFTUD2
chr171290825312908317-CDS,intron-Distal,intron-Proximal3.752806.34662HepG2PRPF8
chr171290881712908917-intron-Distal3.866383.45860K562TIA1
chr171289930612899362-intron-Distal,intron-Proximal4.807046.30573HepG2SF3B4
chr171290873812908827-intron-Distal3.659814.57350K562RBFOX2
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for ELAC2 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for ELAC2 is not available on ENCORE database.

  • 97 RBPs can affect the levels of ELAC2.  








The Knockdown/knockout RNA-Seq assay for ELAC2 is not available on ENCORE database.





97 RBPs can affect the gene expression of ELAC2 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
ELAC2ENSG00000006744.141411.03350996.869700.501204.362403.20070HepG2ABCF1
ELAC2ENSG00000006744.141031.72350803.010100.361504.332803.60460HepG2ACO1
ELAC2ENSG00000006744.141302.48980926.036700.492003.434102.85010HepG2AKAP1
ELAC2ENSG00000006744.141150.48370806.707500.512007.621006.42310HepG2AKAP8L
ELAC2ENSG00000006744.141320.488801531.38870-0.213802.169801.54800HepG2AUH
ELAC2ENSG00000006744.141244.08840802.745000.6320013.4518012.21460HepG2CKAP4
ELAC2ENSG00000006744.14638.73170945.34920-0.565605.015704.11400HepG2CPSF6
ELAC2ENSG00000006744.14997.05840742.627600.424906.042904.87750HepG2DDX19B
ELAC2ENSG00000006744.141279.58800887.059300.528504.416203.63970HepG2DDX3X
ELAC2ENSG00000006744.14555.85720719.01590-0.371303.152102.40560HepG2DNAJC21
ELAC2ENSG00000006744.141048.74340680.197400.624505.727204.43910HepG2EEF2
ELAC2ENSG00000006744.14492.28840732.53030-0.573404.109803.39610HepG2EIF2S1
ELAC2ENSG00000006744.14789.67290552.157400.516103.709702.67140HepG2EIF3D
ELAC2ENSG00000006744.141120.62170809.516500.469103.135402.45620HepG2EIF4A3
ELAC2ENSG00000006744.141093.90390784.603900.479304.822703.72590HepG2EWSR1
ELAC2ENSG00000006744.14568.59970783.51440-0.462502.370101.33260HepG2FUS
ELAC2ENSG00000006744.141188.51680816.815400.541004.576203.70250HepG2FXR1
ELAC2ENSG00000006744.14683.35380491.621500.475003.185302.21520HepG2GEMIN5
ELAC2ENSG00000006744.14853.22520590.458300.531002.949201.80100HepG2GRSF1
ELAC2ENSG00000006744.141054.826801529.49070-0.536009.732908.48980HepG2HNRNPF
ELAC2ENSG00000006744.141011.67980767.289000.398802.873602.16120HepG2HNRNPK
ELAC2ENSG00000006744.14908.846001078.89450-0.247402.215601.60280HepG2HNRNPL
ELAC2ENSG00000006744.14527.256301022.65450-0.9557012.2073011.00500HepG2HNRNPLL
ELAC2ENSG00000006744.141008.881901506.11090-0.578108.202707.01770HepG2IGF2BP1
ELAC2ENSG00000006744.14904.08340684.093500.402202.574301.47890HepG2LARP7
ELAC2ENSG00000006744.141242.30350817.100800.604305.549004.62980HepG2MAGOH
ELAC2ENSG00000006744.141804.98780821.666301.1353016.8629015.40810HepG2MATR3
ELAC2ENSG00000006744.14872.95360577.874600.595002.912401.83280HepG2METAP2
ELAC2ENSG00000006744.14616.266601043.02230-0.759105.054903.71910HepG2MTPAP
ELAC2ENSG00000006744.141515.81320841.014900.8498010.347309.16290HepG2NCBP2
ELAC2ENSG00000006744.14514.65600906.79460-0.817209.250707.94350HepG2NSUN2
ELAC2ENSG00000006744.14950.30490793.945500.259302.155401.40060HepG2PARN
ELAC2ENSG00000006744.141012.42630714.460500.502806.888105.99990HepG2PCBP1
ELAC2ENSG00000006744.14706.01310968.81490-0.456505.603104.54260HepG2PRPF4
ELAC2ENSG00000006744.141068.01140726.989600.554808.064207.22950HepG2PTBP1
ELAC2ENSG00000006744.141731.783401190.247100.5409013.9120012.79580HepG2PUM1
ELAC2ENSG00000006744.141954.316101469.604500.411105.904305.21790HepG2RBM22
ELAC2ENSG00000006744.141206.37160809.070200.576208.847507.98040HepG2NELFE
ELAC2ENSG00000006744.141038.20840753.537900.462205.770504.92200HepG2RECQL
ELAC2ENSG00000006744.141177.194801647.64880-0.485105.151404.25770HepG2RPLP0
ELAC2ENSG00000006744.14802.91050537.286600.579405.593404.75380HepG2RPS19
ELAC2ENSG00000006744.14727.56000539.230000.432102.862101.90570HepG2SERBP1
ELAC2ENSG00000006744.141884.06620924.140001.0276011.6186010.17380HepG2SF3A3
ELAC2ENSG00000006744.14714.224001012.21340-0.503104.402703.53030HepG2SF3B1
ELAC2ENSG00000006744.14993.99730756.891300.393104.256803.54820HepG2SF3B4
ELAC2ENSG00000006744.141181.85340833.014300.504508.924307.87400HepG2SMN1
ELAC2ENSG00000006744.14798.087601126.26940-0.496902.648701.88460HepG2SNRNP70
ELAC2ENSG00000006744.141333.402201659.83960-0.315904.463703.87110HepG2SRFBP1
ELAC2ENSG00000006744.141596.47850790.030101.0148030.1331028.94130HepG2SRSF1
ELAC2ENSG00000006744.141129.796801502.67700-0.411506.189105.21440HepG2SRSF7
ELAC2ENSG00000006744.141237.362001441.09070-0.219902.247201.77410HepG2SSB
ELAC2ENSG00000006744.141659.718001259.002800.398607.194606.27210HepG2SUCLG1
ELAC2ENSG00000006744.14702.37020929.50250-0.404202.492001.84620HepG2SUPV3L1
ELAC2ENSG00000006744.14899.59080710.108400.341102.964502.38660HepG2TAF15
ELAC2ENSG00000006744.14805.26530996.82930-0.307901.935401.31430HepG2TARDBP
ELAC2ENSG00000006744.141335.499501095.437100.285802.374101.56910HepG2TUFM
ELAC2ENSG00000006744.141298.34400861.166200.592206.176605.25500HepG2U2AF1
ELAC2ENSG00000006744.141636.98300791.263301.0487033.6063031.87550HepG2UTP3
ELAC2ENSG00000006744.141157.33370787.075900.556103.535402.33690HepG2XRCC6
ELAC2ENSG00000006744.141350.68300901.371000.5834012.9114011.94980HepG2ZNF622
ELAC2ENSG00000006744.143108.246702477.965700.326803.162501.83360K562APOBEC3C
ELAC2ENSG00000006744.141233.437302220.95690-0.848508.965708.00660K562AQR
ELAC2ENSG00000006744.141562.197301210.786400.367504.439503.25230K562ATP5C1
ELAC2ENSG00000006744.14752.676801117.60530-0.570305.326504.10620K562BOP1
ELAC2ENSG00000006744.141080.070101325.32230-0.295202.412501.32550K562CCDC124
ELAC2ENSG00000006744.14727.762701079.86650-0.569305.822503.99970K562CIRBP
ELAC2ENSG00000006744.14747.730701188.29490-0.668309.093007.65170K562CPSF6
ELAC2ENSG00000006744.142721.029502139.055300.347105.728604.84210K562DDX47
ELAC2ENSG00000006744.141474.545301241.757100.247802.375801.57280K562DKC1
ELAC2ENSG00000006744.14945.948101386.75320-0.551905.747704.40250K562EFTUD2
ELAC2ENSG00000006744.141516.639402264.84590-0.5785012.0099010.66530K562EIF2S2
ELAC2ENSG00000006744.141348.87850790.644600.7706014.7278012.83210K562EIF3G
ELAC2ENSG00000006744.14900.231201242.27530-0.464603.391602.12530K562FKBP4
ELAC2ENSG00000006744.14851.977901209.13960-0.505104.784403.65730K562FMR1
ELAC2ENSG00000006744.14669.625701024.88860-0.614005.636904.28010K562FTO
ELAC2ENSG00000006744.14364.84320699.01900-0.9381012.9800010.01970K562FUS
ELAC2ENSG00000006744.141926.902601065.048900.8553022.0489020.45650K562FXR1
ELAC2ENSG00000006744.14385.85960669.76790-0.795606.029904.89990K562G3BP2
ELAC2ENSG00000006744.14883.601201134.49710-0.360602.742501.95140K562GPKOW
ELAC2ENSG00000006744.142335.575903018.03460-0.369804.184503.25780K562GRSF1
ELAC2ENSG00000006744.141517.259201890.28430-0.317102.955801.84340K562HNRNPA1
ELAC2ENSG00000006744.14802.703601430.30910-0.8334013.7989012.54960K562HNRNPC
ELAC2ENSG00000006744.141011.594501277.41230-0.336602.713201.58400K562HNRNPF
ELAC2ENSG00000006744.141671.091202093.47240-0.325103.842602.78790K562HNRNPU
ELAC2ENSG00000006744.141688.989102104.46870-0.317302.513501.75170K562HSPD1
ELAC2ENSG00000006744.14636.34160968.80320-0.606404.202903.02850K562KRR1
ELAC2ENSG00000006744.141355.412901058.918500.356002.868602.01130K562MAGOH
ELAC2ENSG00000006744.141287.338701056.712300.284702.217701.39940K562MATR3
ELAC2ENSG00000006744.142147.508802993.33090-0.479105.350103.78550K562MSI2
ELAC2ENSG00000006744.141542.042201958.34070-0.344806.957505.84990K562NSUN2
ELAC2ENSG00000006744.141413.597901993.12000-0.495704.445403.39240K562PCBP3
ELAC2ENSG00000006744.141274.154101528.82790-0.262902.199401.48590K562POLR2G
ELAC2ENSG00000006744.141036.530901282.46220-0.307202.256201.44750K562PSIP1
ELAC2ENSG00000006744.141689.790901028.834100.7157012.1931010.84870K562PTBP1
ELAC2ENSG00000006744.142613.606803193.24900-0.289003.471202.39660K562PUM2
ELAC2ENSG00000006744.141458.236901115.064000.387004.487803.75160K562RBM15
ELAC2ENSG00000006744.141771.871101362.106900.379303.691402.43370K562SAFB
ELAC2ENSG00000006744.14687.648301079.06400-0.650005.646204.22490K562SF3B1
ELAC2ENSG00000006744.141417.596801008.643200.490905.663504.65850K562SRSF1
ELAC2ENSG00000006744.141404.974501740.21900-0.308703.049401.45210K562SRSF9
ELAC2ENSG00000006744.14637.62890815.57710-0.355102.779401.49990K562SSB
ELAC2ENSG00000006744.142083.328301533.403300.442105.880004.67400K562SYNCRIP
ELAC2ENSG00000006744.14911.658001233.49060-0.436203.299702.27170K562TIAL1
ELAC2ENSG00000006744.141001.665601310.64040-0.387903.175402.14680K562TRIM56
ELAC2ENSG00000006744.14475.17200670.54990-0.496904.441703.42940K562U2AF2
ELAC2ENSG00000006744.14756.999001382.79470-0.8692011.949009.77710K562UCHL5
ELAC2ENSG00000006744.141469.792002076.46350-0.498509.210007.99310K562UPF1
ELAC2ENSG00000006744.141429.861001776.77510-0.313402.859901.96860K562WDR3
ELAC2ENSG00000006744.141894.525902502.27840-0.401403.131202.20610K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for ELAC2 is not available on ENCORE database.





17 RBPs can affect the splicing of ELAC2 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEELAC2ENSG00000006744.14chr17-129017281290182512899863129000021290347212903591-0.053000.001230.03724excludedK562AKAP8L
SEELAC2ENSG00000006744.14chr17-129017281290182512899863129000021290347212903591-0.054000.001380.02227excludedK562PUS1
SEELAC2ENSG00000006744.14chr17-129017281290182512899863129000021290347212903591-0.065000.000360.01221excludedK562AGGF1
SEELAC2ENSG00000006744.14chr17-1291185312912096129092371290929612913929129139880.087000.000040.00115includedK562HNRNPC
SEELAC2ENSG00000006744.14chr17-129055901290567612903472129035911290575712905896-0.085000.000010.00039excludedK562HNRNPC
A3SSELAC2ENSG00000006744.14chr17-1289986312900044128998631290000212901728129018250.061000.000050.00042longerK562AQR
A3SSELAC2ENSG00000006744.14chr17-1289774112897957128977411289782012898080128981950.102000.000000.00000longerK562AQR
A3SSELAC2ENSG00000006744.14chr17-1290679512906909129067951290689112908305129084180.112000.000000.00000longerK562AQR
A3SSELAC2ENSG00000006744.14chr17-1289901912899181128990191289912912899256128992950.079000.000000.00000longerK562AQR
A3SSELAC2ENSG00000006744.14chr17-1290172812901857129017281290182512903472129035910.053000.000630.00456longerK562AQR
RIELAC2ENSG00000006744.14chr17-128980801289837912898080128982011289827912898379-0.064000.000080.01527excludedK562APOBEC3C
RIELAC2ENSG00000006744.14chr17-1289808012898379128980801289820112898279128983790.246000.000160.00405includedK562SF3B4
RIELAC2ENSG00000006744.14chr17-128980801289837912898080128982011289827912898379-0.097000.001290.06520excludedHepG2TBRG4
RIELAC2ENSG00000006744.14chr17-128992561290000212899256128992951289986312900002-0.067000.001100.01477excludedHepG2SF3A3
RIELAC2ENSG00000006744.14chr17-1289925612900002128992561289929512899863129000020.134000.000070.00341includedHepG2UCHL5
RIELAC2ENSG00000006744.14chr17-1289925612900002128992561289929512899863129000020.085000.002110.06448includedHepG2TIA1
RIELAC2ENSG00000006744.14chr17-1289925612900002128992561289929512899863129000020.067000.005030.05385includedHepG2PRPF8
RIELAC2ENSG00000006744.14chr17-1289925612900002128992561289929512899863129000020.111000.000500.00770includedK562AGGF1
RIELAC2ENSG00000006744.14chr17-1289925612900002128992561289929512899863129000020.069000.003310.08386includedHepG2MATR3
RIELAC2ENSG00000006744.14chr17-1289808012898379128980801289820112898279128983790.120000.000100.01646includedK562SERBP1
RIELAC2ENSG00000006744.14chr17-1289925612900002128992561289929512899863129000020.095000.000320.00362includedHepG2SF3B4
RIELAC2ENSG00000006744.14chr17-1289925612900002128992561289929512899863129000020.077000.001440.01820includedHepG2HNRNPK
RIELAC2ENSG00000006744.14chr17-1289808012898379128980801289820112898279128983790.142000.000110.00217includedHepG2HNRNPK
RIELAC2ENSG00000006744.14chr17-1289925612900002128992561289929512899863129000020.070000.003590.06499includedHepG2PTBP1
RIELAC2ENSG00000006744.14chr17-1290559012905896129055901290567612905757129058960.090000.000170.00283includedK562EFTUD2
RIELAC2ENSG00000006744.14chr17-1289808012898379128980801289820112898279128983790.099000.000410.00589includedK562EFTUD2
RIELAC2ENSG00000006744.14chr17-1289808012898379128980801289820112898279128983790.118000.000180.00141includedK562AQR
RIELAC2ENSG00000006744.14chr17-1290559012905896129055901290567612905757129058960.051000.003390.02025includedK562AQR

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for ELAC2 is not avaliable on ENCORE database.