PPP1R8

General Information

Gene Name : PPP1R8
Gene ID : ENSG00000117751.17
Essential Gene : Yes

Functions

Splicing regulation

Localization(RBPImage: PPP1R8)

Nuclei
Unknown Nuclear Foci
Cytoplasm
Cytosolic

Domains (AlphaFold: PPP1R8)

No checked domain (RRM, ZNF, KH, Helicase, Nuclease, dRBM or PUM_HD)

Antibody Validation

MBLI: RN068PW

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	PPP1R8	ENSG00000117751.17	38.96	47.29	43.12	ENCSR000AEF
HepG2	PPP1R8	ENSG00000117751.17	70.59	53.76	62.17	ENCSR985KAT
K562	PPP1R8	ENSG00000117751.17	95.27	72.23	83.75	ENCSR000AEO

Assays

2 Released experiments are available on ENCORE database.

Assay Type	Exp_Name	ENCODE ID	Target label	Biosample	Status	Linked Antibody	Controls	Method	Note
knockdown followed by RNA-seq	PPP1R8-BGKLV28-K562	ENCSR844QNT	PPP1R8	K562	Released		ENCSR164MUK	shRNA	KD% = 43.2,57.4
knockdown followed by RNA-seq	PPP1R8-BGHcLV12-HepG2	ENCSR592AQT	PPP1R8	HepG2	Released		ENCSR827PII	CRISPR	KD% = 74.3,67.6

eCLIP

No eCLIP experiment available

Antibody Validation

GeneName	Antibody_DCC_ID	Product_ID	Lot_ID	Phosphate	HepG2 Primary Validation	K562 Primary Validation	HepG2 Secondary Validation	K562 Secondary Validation
PPP1R8	ENCAB563YNZ	RN068PW	1			NotSatisfied, ENCODE4	BGHcLV12-63, Released, ENCODE4	BGKLV28-41, Released, ENCODE3

KD RNA-Seq

GeneName	Cell_Line	Method	Exp_ID	Control_ID	Sample_reps	Control_reps	KD%	Status	Project
PPP1R8	K562	shRNA			BGKLV13-17,BGKLV13-18	BGKLV13-1,BGKLV13-2		NotSatisfied	ENCODE3
PPP1R8	K562	shRNA	ENCSR844QNT	ENCSR164MUK	PPP1R8_BGKLV28-41,PPP1R8_BGKLV28-42	non-target_BGKLV28-1,non-target_BGKLV28-2	43.2,57.4	Released	ENCODE3
PPP1R8	HepG2	shRNA			BGHLV23-29,BGHLV23-30	BGHLV23-1,BGHLV23-2	0.0,0.0	NotSatisfied	ENCODE3
PPP1R8	HepG2	shRNA			BGHLV31-49,BGHLV31-50	BGHLV31-1,BGHLV31-2		NotSatisfied	ENCODE3
PPP1R8	HepG2	CRISPR	ENCSR592AQT	ENCSR827PII	PPP1R8-BGHcLV12-63,PPP1R8-BGHcLV12-64	NT-BGHcLV12-1,NT-BGHcLV12-2	74.3,67.6	Released	ENCODE4

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

PPP1R8: Click to RBP Image Database

Nuclei

Unknown Nuclear Foci

Cytoplasm

Cytosolic

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela
PPP1R8	Product_ID: RN068PW Lot_ID: 1 Source: MBLI Target Name: PPP1R8-human

Summary
Proteins Bound to RBP RNA

RNA Targets

eCLIP assay for PPP1R8 is not avaliable on ENCORE database.

Proteins bound to RNA

PPP1R8 RNA is bound by 35 proteins.

eCLIP assay for PPP1R8 is not avaliable on ENCORE database.

35 proteins are bound to PPP1R8 RNA:

Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr1	28169660	28169704	+	3'-UTR,CDS,intron-Proximal	4.90432	11.65116	K562	AQR
chr1	28169637	28169717	+	3'-UTR,CDS,intron-Proximal	5.81191	11.49904	K562	SF3B4
chr1	28169651	28169700	+	3'-UTR,CDS,intron-Proximal	4.70530	4.38082	K562	SMNDC1
chr1	28169718	28169826	+	3'-UTR,CDS	3.11621	7.92361	K562	ZNF622
chr1	28176980	28177042	+	3'-UTR,intron-Distal,intron-Proximal	3.36583	4.11185	K562	TROVE2
chr1	28176992	28177102	+	3'-UTR,intron-Distal,intron-Proximal	3.38944	4.73359	K562	PUM1
chr1	28176983	28177077	+	3'-UTR,intron-Distal,intron-Proximal	4.57901	4.55101	HepG2	PRPF4
chr1	28176989	28177064	+	3'-UTR,intron-Distal,intron-Proximal	3.19571	6.58220	K562	FASTKD2
chr1	28177637	28177701	+	3'-UTR,intron-Distal	4.32123	3.76686	K562	IGF2BP1
chr1	28177358	28177414	+	3'-UTR,intron-Distal	3.78989	5.73934	K562	IGF2BP2
chr1	28177914	28178020	+	3'-UTR,intron-Distal,intron-Proximal	6.54726	400.00000	K562	PUM2
chr1	28176992	28177038	+	3'-UTR,intron-Distal,intron-Proximal	3.55754	13.70979	K562	DDX6
chr1	28177042	28177116	+	3'-UTR,intron-Distal	3.43772	12.50254	K562	PABPC4
chr1	28177862	28177872	+	3'-UTR,intron-Distal	3.01361	6.82055	K562	YBX3
chr1	28176993	28177089	+	3'-UTR,intron-Distal,intron-Proximal	4.22786	5.17497	K562	APOBEC3C
chr1	28169835	28169919	+	3'-UTR,CDS,intron-Proximal	4.45984	7.50107	K562	AQR
chr1	28177038	28177126	+	3'-UTR,intron-Distal	4.14650	26.84191	K562	DDX6
chr1	28176993	28177085	+	3'-UTR,intron-Distal,intron-Proximal	3.86550	4.36276	HepG2	LARP4
chr1	28176966	28177061	+	3'-UTR,intron-Distal,intron-Proximal	5.31066	9.83211	HepG2	PCBP2
chr1	28173537	28173629	+	3'-UTR,CDS,intron-Proximal	4.46581	5.93840	HepG2	PRPF8
chr1	28177272	28177358	+	3'-UTR,intron-Distal	4.76104	6.84107	K562	IGF2BP2
chr1	28177935	28178026	+	3'-UTR,intron-Distal,intron-Proximal	4.78411	3.35973	HepG2	FUBP3
chr1	28176989	28177081	+	3'-UTR,intron-Distal,intron-Proximal	4.85151	9.52364	K562	PUM2
chr1	28176993	28177065	+	3'-UTR,intron-Distal,intron-Proximal	3.55128	3.40672	HepG2	FUBP3
chr1	28176982	28177086	+	3'-UTR,intron-Distal,intron-Proximal	4.50554	22.76138	K562	GTF2F1
chr1	28176983	28177100	+	3'-UTR,intron-Distal,intron-Proximal	3.42678	19.59337	K562	FAM120A
chr1	28176999	28177092	+	3'-UTR,intron-Distal,intron-Proximal	3.53778	4.03335	HepG2	CDC40
chr1	28169714	28169830	+	3'-UTR,CDS	3.23471	3.84837	K562	GRWD1
chr1	28159300	28159384	+	5'-UTR,CDS,intron-Proximal	4.33466	3.89565	K562	PRPF8
chr1	28157332	28157375	+	5'-UTR,CDS	3.97119	7.62404	K562	DDX3X
chr1	28157375	28157402	+	5'-UTR,CDS	6.17768	15.52410	K562	DDX3X
chr1	28159263	28159326	+	5'-UTR,CDS,intron-Proximal	5.31935	21.21388	K562	DDX3X
chr1	28176607	28176695	+	CDS	3.04251	4.27175	K562	UCHL5
chr1	28167682	28167738	+	CDS,intron-Distal	3.26692	4.74755	K562	ZNF622
chr1	28173592	28173679	+	CDS,intron-Proximal	4.70412	9.46915	K562	AQR
chr1	28176797	28176884	+	CDS	4.55115	5.65349	K562	RBM15
chr1	28176595	28176653	+	CDS,intron-Proximal	3.50989	4.22917	HepG2	PPIG
chr1	28176849	28176922	+	CDS	5.63708	24.39476	K562	PUM2
chr1	28176667	28176715	+	CDS	3.53635	4.80676	K562	RBM15
chr1	28167742	28167850	+	CDS,intron-Distal,intron-Proximal	3.32746	9.68935	K562	AQR
chr1	28160907	28160955	+	intron-Distal	3.77551	12.85589	K562	AATF
chr1	28160980	28161000	+	intron-Distal	6.32927	400.00000	HepG2	DKC1
chr1	28161025	28161065	+	intron-Distal	3.65351	5.92314	K562	ZC3H8
chr1	28160910	28160916	+	intron-Distal	5.04345	18.18078	K562	PTBP1
chr1	28160916	28160951	+	intron-Distal	4.54749	29.47227	K562	PTBP1
chr1	28160915	28160949	+	intron-Distal	3.05069	17.55314	HepG2	SF3A3
chr1	28161044	28161055	+	intron-Distal	6.59737	400.00000	HepG2	DKC1
chr1	28160910	28160939	+	intron-Distal	3.19980	19.94138	K562	SMNDC1
chr1	28161005	28161008	+	intron-Distal	8.00243	400.00000	HepG2	DKC1
chr1	28160916	28160931	+	intron-Distal	8.24463	400.00000	HepG2	DKC1
chr1	28160907	28160916	+	intron-Distal	8.12388	400.00000	HepG2	DKC1
chr1	28161022	28161044	+	intron-Distal	6.88780	400.00000	HepG2	DKC1
chr1	28160924	28160948	+	intron-Distal	4.30050	33.31171	HepG2	SMNDC1
chr1	28160912	28160954	+	intron-Distal	4.31646	20.38690	HepG2	NOLC1
chr1	28160927	28160940	+	intron-Distal	3.42301	4.92170	K562	PHF6
chr1	28160931	28160954	+	intron-Distal	8.38299	400.00000	HepG2	DKC1
chr1	28161019	28161067	+	intron-Distal	3.00666	400.00000	K562	PTBP1
chr1	28160912	28160954	+	intron-Distal	3.05883	4.34922	HepG2	EIF3H
chr1	28160907	28160952	+	intron-Distal	5.36811	30.02544	HepG2	PTBP1
chr1	28161013	28161022	+	intron-Distal	7.72772	400.00000	HepG2	DKC1
chr1	28161055	28161078	+	intron-Distal	6.61283	400.00000	HepG2	DKC1
chr1	28161067	28161078	+	intron-Distal	3.86789	25.73874	K562	PTBP1
chr1	28160961	28160995	+	intron-Distal	3.13370	14.67500	HepG2	NOLC1
chr1	28160954	28160980	+	intron-Distal	6.22471	400.00000	HepG2	DKC1
chr1	28176559	28176599	+	intron-Proximal	4.07767	7.79506	K562	AQR
chr1	28176551	28176559	+	intron-Proximal	4.22183	6.48405	K562	AQR
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

eCLIP assay for PPP1R8 is not avaliable on ENCORE database.

Diffrential Expression

942 differentially expressed genes after Knockdown/Knockout PPP1R8 protein.

79 RBPs can affect the levels of PPP1R8.

942 differentially expressed genes after Knockdown/Knockout PPP1R8 protein :

Only display 100 entries as example. Please click "View All" button to see all 942 entries.

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
ARHGAP33	ENSG00000004777.14	1142.44230	640.86510	0.83390	3.67500	1.91540	K562	PPP1R8
RPAP3	ENSG00000005175.5	1668.06040	2874.21380	-0.78500	3.56940	1.83960	K562	PPP1R8
FAM214B	ENSG00000005238.15	418.85740	194.57870	1.10600	4.74460	2.66190	K562	PPP1R8
WDR54	ENSG00000005448.12	262.63440	109.25780	1.26520	3.85090	2.03200	K562	PPP1R8
RHBDD2	ENSG00000005486.12	1356.36030	735.03870	0.88370	3.06780	1.50970	K562	PPP1R8
ZNF195	ENSG00000005801.12	558.84100	1077.98490	-0.94780	4.84630	2.75260	K562	PPP1R8
OSBPL7	ENSG00000006025.7	808.55070	421.59200	0.93940	4.33980	2.35530	K562	PPP1R8
TNFRSF12A	ENSG00000006327.9	191.30890	89.75320	1.09180	3.03080	1.48620	K562	PPP1R8
TRAPPC6A	ENSG00000007255.6	339.17850	191.82100	0.82220	3.15720	1.55950	K562	PPP1R8
RHBDF1	ENSG00000007384.11	871.28430	309.48200	1.49320	8.79030	5.76610	K562	PPP1R8
BAIAP3	ENSG00000007516.9	293.16140	162.13210	0.85440	2.95550	1.43990	K562	PPP1R8
MYLIP	ENSG00000007944.10	1798.01290	1111.03530	0.69440	2.81570	1.36030	K562	PPP1R8
BAZ1B	ENSG00000009954.6	7438.25420	11762.59340	-0.66120	2.75850	1.33060	K562	PPP1R8
TMEM159	ENSG00000011638.6	333.33210	145.78170	1.19310	4.87550	2.77510	K562	PPP1R8
BRCA1	ENSG00000012048.15	1734.38100	4069.74660	-1.23050	3.74730	1.96240	K562	PPP1R8
MBTPS2	ENSG00000012174.7	327.98220	590.31640	-0.84790	3.60950	1.86110	K562	PPP1R8
EXTL3	ENSG00000012232.4	949.73410	555.78680	0.77290	3.31090	1.66060	K562	PPP1R8
MVP	ENSG00000013364.14	63.53430	17.64060	1.84850	4.01430	2.14020	K562	PPP1R8
ZC3H3	ENSG00000014164.6	1014.02750	384.39970	1.39930	2.88140	1.39420	K562	PPP1R8
RNH1	ENSG00000023191.12	2363.00900	1461.85180	0.69270	3.12220	1.53870	K562	PPP1R8
AKAP11	ENSG00000023516.7	1186.32500	2191.91960	-0.88570	4.72940	2.65100	K562	PPP1R8
VIM	ENSG00000026025.9	11472.18250	7342.49960	0.64370	2.80600	1.35460	K562	PPP1R8
BAK1	ENSG00000030110.8	548.63510	277.40230	0.98380	4.32140	2.34790	K562	PPP1R8
IFT88	ENSG00000032742.13	114.31960	310.06770	-1.43950	3.45650	1.76350	K562	PPP1R8
BOD1L1	ENSG00000038219.8	1399.27460	2572.82760	-0.87870	4.65110	2.58530	K562	PPP1R8
SPDL1	ENSG00000040275.12	548.00730	1223.89640	-1.15920	3.28750	1.64430	K562	PPP1R8
RTN4R	ENSG00000040608.9	87.21460	21.94860	1.99030	5.56200	3.25520	K562	PPP1R8
CUL7	ENSG00000044090.4	3556.56290	1787.39440	0.99250	5.62640	3.30870	K562	PPP1R8
GOPC	ENSG00000047932.9	893.81350	1859.64870	-1.05700	6.05150	3.59490	K562	PPP1R8
PRSS8	ENSG00000052344.11	543.81820	296.75890	0.87370	3.54700	1.82720	K562	PPP1R8
AKR7A2	ENSG00000053371.8	1492.27450	843.13670	0.82360	3.70740	1.93660	K562	PPP1R8
MRTO4	ENSG00000053372.4	910.96100	1536.27200	-0.75400	2.85320	1.37960	K562	PPP1R8
PHPT1	ENSG00000054148.13	1483.36600	621.49670	1.25500	6.01640	3.57980	K562	PPP1R8
CYFIP2	ENSG00000055163.14	204.22110	92.85400	1.13700	3.88250	2.04800	K562	PPP1R8
PCGF2	ENSG00000056661.9	1132.04940	647.46330	0.80600	3.44070	1.75200	K562	PPP1R8
TRAF3IP2	ENSG00000056972.14	758.22570	443.01990	0.77520	2.93970	1.43000	K562	PPP1R8
SEC61A1	ENSG00000058262.5	6423.34800	3818.45500	0.75020	3.31720	1.66450	K562	PPP1R8
APPBP2	ENSG00000062725.5	301.96530	498.97140	-0.72460	2.75210	1.32670	K562	PPP1R8
CA11	ENSG00000063180.4	463.29960	247.71340	0.90320	3.46400	1.76960	K562	PPP1R8
EPN1	ENSG00000063245.10	2434.53850	1520.17620	0.67930	2.96480	1.44230	K562	PPP1R8
ASUN	ENSG00000064102.10	1466.70360	2689.81970	-0.87490	4.47910	2.46060	K562	PPP1R8
NGFR	ENSG00000064300.4	127.53600	24.55240	2.37690	8.94350	5.85860	K562	PPP1R8
CNN2	ENSG00000064666.10	4587.08790	2726.67540	0.75030	3.41660	1.73480	K562	PPP1R8
PDIA5	ENSG00000065485.13	1519.30940	947.82010	0.68060	2.90910	1.40570	K562	PPP1R8
NDUFB4	ENSG00000065518.7	1975.66470	863.44640	1.19410	4.96610	2.83540	K562	PPP1R8
TLE2	ENSG00000065717.10	659.76590	353.23110	0.90120	3.99250	2.12250	K562	PPP1R8
ASPM	ENSG00000066279.12	1901.28250	4210.46390	-1.14700	7.63070	4.77630	K562	PPP1R8
ZNRD1	ENSG00000066379.10	903.35960	495.28460	0.86690	3.99890	2.12620	K562	PPP1R8
MYO9A	ENSG00000066933.11	293.41950	497.47420	-0.76170	2.96480	1.44230	K562	PPP1R8
KLF6	ENSG00000067082.10	2436.16560	1503.04500	0.69660	2.94670	1.43350	K562	PPP1R8
RRP15	ENSG00000067533.5	425.44870	1013.42890	-1.25220	2.96070	1.44050	K562	PPP1R8
RASSF1	ENSG00000068028.13	1204.85220	760.14130	0.66440	2.75900	1.33070	K562	PPP1R8
PLEKHH3	ENSG00000068137.10	2006.90200	939.12120	1.09550	6.41220	3.89550	K562	PPP1R8
POLR1A	ENSG00000068654.11	998.80080	1583.50710	-0.66490	2.89880	1.40100	K562	PPP1R8
IP6K2	ENSG00000068745.10	1879.91140	1132.75310	0.73070	3.08570	1.51730	K562	PPP1R8
STON1-GTF2A1L	ENSG00000068781.16	0.93470	28.99060	-4.95500	5.83990	3.47520	K562	PPP1R8
IFT80	ENSG00000068885.10	375.96350	634.38520	-0.75480	2.95510	1.43990	K562	PPP1R8
SIRT2	ENSG00000068903.15	1283.06610	661.05030	0.95670	4.70680	2.63270	K562	PPP1R8
RNF126	ENSG00000070423.13	1144.22920	547.50800	1.06330	5.75260	3.41590	K562	PPP1R8
OSBPL3	ENSG00000070882.8	966.05420	1542.91780	-0.67550	2.83210	1.36890	K562	PPP1R8
RPL31	ENSG00000071082.6	9601.31630	4941.67500	0.95810	5.22990	3.04260	K562	PPP1R8
ATP6AP1	ENSG00000071553.12	3438.42400	1681.56900	1.03180	5.79120	3.44670	K562	PPP1R8
HMMR	ENSG00000072571.15	3276.62930	6445.71700	-0.97610	2.85460	1.37980	K562	PPP1R8
AP1M1	ENSG00000072958.4	1003.90500	564.09530	0.83150	3.63440	1.88190	K562	PPP1R8
SCARB1	ENSG00000073060.11	7936.14670	3880.84560	1.03200	3.08840	1.51940	K562	PPP1R8
PANX2	ENSG00000073150.9	457.59680	246.32860	0.89340	3.80930	2.00460	K562	PPP1R8
ACTR6	ENSG00000075089.5	1075.50630	2065.28140	-0.94130	3.33320	1.67150	K562	PPP1R8
ZNF37A	ENSG00000075407.13	436.24600	1037.88680	-1.25040	7.53290	4.73200	K562	PPP1R8
ACTB	ENSG00000075624.9	56361.06910	34665.51130	0.70110	3.22980	1.60470	K562	PPP1R8
TPD52	ENSG00000076554.11	73.70110	25.74180	1.51750	3.26460	1.62760	K562	PPP1R8
ACACB	ENSG00000076555.11	168.78230	82.30880	1.03590	3.09790	1.52360	K562	PPP1R8
RAP1GAP	ENSG00000076864.15	2191.74370	1311.86900	0.74040	2.88210	1.39430	K562	PPP1R8
XAB2	ENSG00000076924.7	2738.69220	1739.61490	0.65460	2.87480	1.39200	K562	PPP1R8
MAP2K7	ENSG00000076984.13	1671.44530	973.77520	0.77930	2.78210	1.34210	K562	PPP1R8
TOP2B	ENSG00000077097.9	5859.39110	9146.05320	-0.64240	2.71800	1.30420	K562	PPP1R8
LRCH4	ENSG00000077454.11	3658.27620	1721.58410	1.08730	6.60360	4.01010	K562	PPP1R8
UBE2K	ENSG00000078140.9	2555.36510	4121.66310	-0.68970	3.08190	1.51660	K562	PPP1R8
N4BP2	ENSG00000078177.9	872.00260	1429.70690	-0.71330	2.99470	1.46010	K562	PPP1R8
TP53INP2	ENSG00000078804.8	1051.07320	523.39370	1.00580	4.25980	2.31000	K562	PPP1R8
DUSP13	ENSG00000079393.16	275.71960	137.01760	1.00870	3.55180	1.82860	K562	PPP1R8
FDFT1	ENSG00000079459.8	26783.13720	14923.85590	0.84360	3.81820	2.00660	K562	PPP1R8
DNM2	ENSG00000079805.12	10834.39810	6286.76460	0.78510	3.86250	2.03720	K562	PPP1R8
KIAA0020	ENSG00000080608.9	932.62120	1668.53180	-0.83920	3.86400	2.03720	K562	PPP1R8
BZW1	ENSG00000082153.13	1840.42790	2985.75580	-0.69810	2.91260	1.40800	K562	PPP1R8
LYRM2	ENSG00000083099.6	471.32220	898.11750	-0.93020	4.31700	2.34790	K562	PPP1R8
RPS5	ENSG00000083845.4	14018.83010	6708.94890	1.06310	6.48350	3.93640	K562	PPP1R8
ZMPSTE24	ENSG00000084073.4	619.43030	1042.61500	-0.75120	3.09380	1.52080	K562	PPP1R8
GSTP1	ENSG00000084207.11	16571.20150	9743.90320	0.76600	3.87210	2.04250	K562	PPP1R8
KIAA1467	ENSG00000084444.9	245.28740	118.41240	1.05060	3.58880	1.85120	K562	PPP1R8
MAPRE3	ENSG00000084764.6	2777.21440	1491.41090	0.89690	3.25010	1.61900	K562	PPP1R8
ATRX	ENSG00000085224.16	866.39730	1646.64830	-0.92640	4.06930	2.16630	K562	PPP1R8
CHERP	ENSG00000085872.10	2580.75070	1494.01460	0.78850	3.55670	1.82980	K562	PPP1R8
FTL	ENSG00000087086.9	93986.83620	46488.97200	1.01550	5.96840	3.55090	K562	PPP1R8
DDX18	ENSG00000088205.8	2027.12920	3292.36780	-0.69970	3.06550	1.50820	K562	PPP1R8
TESC	ENSG00000088992.13	273.25880	153.74080	0.82970	2.82740	1.36680	K562	PPP1R8
RPLP0	ENSG00000089157.11	107261.17470	65360.21500	0.71450	3.47180	1.77510	K562	PPP1R8
FXYD5	ENSG00000089327.10	7497.22540	4470.62290	0.74580	3.12130	1.53870	K562	PPP1R8
GANAB	ENSG00000089597.12	18615.72280	11339.72750	0.71500	3.19180	1.58240	K562	PPP1R8
MLF2	ENSG00000089693.6	4544.58410	2677.29870	0.76330	3.46770	1.77190	K562	PPP1R8
BLVRB	ENSG00000090013.5	7026.13280	4299.66680	0.70840	3.26040	1.62420	K562	PPP1R8
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

79 RBPs can affect the gene expression of PPP1R8 :

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
PPP1R8	ENSG00000117751.13	753.49910	988.29050	-0.39130	2.86230	2.08370	HepG2	AKAP8L
PPP1R8	ENSG00000117751.13	1376.22830	1592.95420	-0.21100	2.05640	1.44770	HepG2	AUH
PPP1R8	ENSG00000117751.13	649.43210	1004.53700	-0.62930	4.83110	3.67250	HepG2	BCLAF1
PPP1R8	ENSG00000117751.13	577.25920	841.75520	-0.54420	4.48050	3.62380	HepG2	CPSF6
PPP1R8	ENSG00000117751.13	1219.58170	1421.96940	-0.22150	2.25890	1.57930	HepG2	DAZAP1
PPP1R8	ENSG00000117751.13	562.87960	756.85200	-0.42720	3.32090	1.83330	HepG2	DDX52
PPP1R8	ENSG00000117751.13	442.01460	955.87150	-1.11270	8.16690	6.53880	HepG2	DDX59
PPP1R8	ENSG00000117751.13	949.77840	1225.80740	-0.36810	2.13310	1.58350	HepG2	DDX6
PPP1R8	ENSG00000117751.13	632.00960	822.64630	-0.38030	3.50620	2.72130	HepG2	DNAJC21
PPP1R8	ENSG00000117751.13	680.63240	1178.64630	-0.79220	7.30810	6.37830	HepG2	EIF2S1
PPP1R8	ENSG00000117751.13	1041.77090	1343.90470	-0.36740	2.77970	1.96280	HepG2	EIF4G2
PPP1R8	ENSG00000117751.13	1580.21380	1828.85330	-0.21080	2.00220	1.47290	HepG2	ETF1
PPP1R8	ENSG00000117751.13	497.08230	655.17260	-0.39840	2.71000	1.55530	HepG2	FAM120A
PPP1R8	ENSG00000117751.13	455.24530	843.17660	-0.88920	3.80720	2.61350	HepG2	FTO
PPP1R8	ENSG00000117751.13	545.50100	743.71200	-0.44720	3.39360	2.52700	HepG2	FUBP3
PPP1R8	ENSG00000117751.13	836.29480	1219.08990	-0.54370	3.89780	3.11470	HepG2	G3BP1
PPP1R8	ENSG00000117751.13	566.20030	954.22330	-0.75300	6.94520	5.96020	HepG2	GPKOW
PPP1R8	ENSG00000117751.13	1097.91590	1306.86980	-0.25130	2.32850	1.46240	HepG2	HNRNPA2B1
PPP1R8	ENSG00000117751.13	900.66730	1238.59550	-0.45960	6.67820	5.62910	HepG2	HNRNPF
PPP1R8	ENSG00000117751.13	961.85210	1233.99340	-0.35940	2.16270	1.53970	HepG2	HNRNPK
PPP1R8	ENSG00000117751.13	569.57470	910.63030	-0.67700	6.36100	5.45120	HepG2	HNRNPLL
PPP1R8	ENSG00000117751.13	952.58000	1219.66090	-0.35660	3.38480	2.59090	HepG2	IGF2BP1
PPP1R8	ENSG00000117751.13	917.44800	1239.24610	-0.43380	2.98830	2.29090	HepG2	IGF2BP2
PPP1R8	ENSG00000117751.13	797.22090	937.40250	-0.23370	2.18780	1.52750	HepG2	ILF2
PPP1R8	ENSG00000117751.13	925.60590	1246.34290	-0.42920	2.18190	1.30460	HepG2	KHSRP
PPP1R8	ENSG00000117751.13	666.49000	928.66300	-0.47860	2.37930	1.48810	HepG2	MTPAP
PPP1R8	ENSG00000117751.13	976.10980	1353.02670	-0.47110	2.50560	1.90160	HepG2	NCBP2
PPP1R8	ENSG00000117751.13	532.09660	807.42750	-0.60160	5.17070	4.16160	HepG2	NSUN2
PPP1R8	ENSG00000117751.13	758.52150	1205.17890	-0.66800	5.57460	4.56140	HepG2	PABPC4
PPP1R8	ENSG00000117751.13	676.56660	818.51710	-0.27480	2.07640	1.43020	HepG2	PPIL4
PPP1R8	ENSG00000117751.13	701.48540	843.93610	-0.26670	2.27690	1.56750	HepG2	PRPF4
PPP1R8	ENSG00000117751.13	601.86310	876.97320	-0.54310	3.71210	2.79330	HepG2	PRPF8
PPP1R8	ENSG00000117751.13	1086.65020	1346.01600	-0.30880	2.32600	1.77280	HepG2	PUF60
PPP1R8	ENSG00000117751.13	855.10080	1293.46030	-0.59710	8.64740	7.63720	HepG2	QKI
PPP1R8	ENSG00000117751.13	846.70350	1173.89180	-0.47140	4.85210	3.98160	HepG2	RBM25
PPP1R8	ENSG00000117751.13	1062.68740	1237.89550	-0.22020	1.92390	1.39680	HepG2	RECQL
PPP1R8	ENSG00000117751.13	935.21150	1334.30150	-0.51270	5.30600	4.40070	HepG2	RPLP0
PPP1R8	ENSG00000117751.13	623.84330	817.25350	-0.38960	4.22230	3.45560	HepG2	SAFB2
PPP1R8	ENSG00000117751.13	1499.48530	1132.89620	0.40440	2.31230	1.69570	HepG2	SF3A3
PPP1R8	ENSG00000117751.13	484.61030	901.36040	-0.89530	11.00830	9.68960	HepG2	SF3B1
PPP1R8	ENSG00000117751.13	1061.26640	1243.42210	-0.22850	2.03130	1.51300	HepG2	SF3B4
PPP1R8	ENSG00000117751.13	1003.81610	1290.67350	-0.36260	4.96170	4.06490	HepG2	SLBP
PPP1R8	ENSG00000117751.13	729.37860	1002.91570	-0.45950	2.24610	1.54540	HepG2	SNRNP70
PPP1R8	ENSG00000117751.13	1821.79560	1297.85750	0.48910	8.94060	8.19840	HepG2	SRSF1
PPP1R8	ENSG00000117751.13	915.83550	1216.88620	-0.41000	5.54890	4.61990	HepG2	SRSF7
PPP1R8	ENSG00000117751.13	834.61780	1055.87100	-0.33920	3.80340	3.17790	HepG2	SRSF9
PPP1R8	ENSG00000117751.13	583.63160	731.27690	-0.32540	2.24070	1.39080	HepG2	SUPT6H
PPP1R8	ENSG00000117751.13	831.48330	1131.45760	-0.44440	2.46950	1.82620	HepG2	SUPV3L1
PPP1R8	ENSG00000117751.13	816.68520	1166.54830	-0.51440	6.88950	6.07400	HepG2	TAF15
PPP1R8	ENSG00000117751.13	557.09390	887.50790	-0.67180	6.66460	5.60540	HepG2	TARDBP
PPP1R8	ENSG00000117751.13	808.58840	1071.91660	-0.40670	3.82560	2.85010	HepG2	TIA1
PPP1R8	ENSG00000117751.13	658.46520	891.71130	-0.43750	4.24480	3.65330	HepG2	TIAL1
PPP1R8	ENSG00000117751.13	557.30080	899.69150	-0.69100	11.64260	10.60270	HepG2	TRIM56
PPP1R8	ENSG00000117751.13	1173.23210	926.42650	0.34060	2.12910	1.57070	HepG2	U2AF1
PPP1R8	ENSG00000117751.13	1084.44530	1391.98120	-0.36020	2.03210	1.32060	HepG2	UBE2L3
PPP1R8	ENSG00000117751.13	497.97190	668.43440	-0.42470	2.41950	1.70870	HepG2	UCHL5
PPP1R8	ENSG00000117751.13	631.93900	1004.70560	-0.66890	11.74560	10.48670	HepG2	UPF1
PPP1R8	ENSG00000117751.13	1153.08100	970.00400	0.24930	2.29290	1.73680	HepG2	UTP3
PPP1R8	ENSG00000117751.13	761.06190	1104.98400	-0.53790	9.77920	8.90910	HepG2	ZNF622
PPP1R8	ENSG00000117751.13	1684.41880	1354.27830	0.31460	2.58250	1.44790	K562	AARS
PPP1R8	ENSG00000117751.13	2025.86250	1749.95270	0.21110	2.30290	1.77720	K562	AGGF1
PPP1R8	ENSG00000117751.13	3887.16810	2975.43160	0.38550	3.91280	3.23890	K562	AQR
PPP1R8	ENSG00000117751.13	3168.07610	2481.87010	0.35210	5.74910	4.86090	K562	DDX47
PPP1R8	ENSG00000117751.13	2280.73770	1959.42290	0.21900	2.23250	1.45700	K562	DKC1
PPP1R8	ENSG00000117751.13	2156.73730	2481.70390	-0.20250	2.03270	1.39930	K562	EIF2S2
PPP1R8	ENSG00000117751.13	1838.67750	1450.43180	0.34210	3.92930	2.98900	K562	EIF3G
PPP1R8	ENSG00000117751.13	1743.38930	1212.12640	0.52430	5.94610	4.75270	K562	EIF4A3
PPP1R8	ENSG00000117751.13	2054.22850	1260.55250	0.70440	16.05610	14.70580	K562	FXR1
PPP1R8	ENSG00000117751.13	1178.39060	1482.27460	-0.33100	2.75680	2.16090	K562	HNRNPC
PPP1R8	ENSG00000117751.13	2135.94390	1686.38370	0.34080	2.53350	1.35690	K562	HNRNPK
PPP1R8	ENSG00000117751.13	2220.39070	1774.52070	0.32330	3.09790	2.20670	K562	MAGOH
PPP1R8	ENSG00000117751.13	1891.05310	1356.41600	0.47930	4.75150	3.77220	K562	PRPF8
PPP1R8	ENSG00000117751.13	2093.41930	1724.05640	0.28000	2.55080	1.90900	K562	PTBP1
PPP1R8	ENSG00000117751.13	5356.16750	4061.94960	0.39890	6.98060	5.22660	K562	PUM1
PPP1R8	ENSG00000117751.13	2282.63230	1805.83670	0.33790	2.61860	2.08690	K562	PUS1
PPP1R8	ENSG00000117751.13	2047.25400	1759.51730	0.21840	2.01140	1.49100	K562	RBM15
PPP1R8	ENSG00000117751.13	2037.88300	1653.17610	0.30170	2.41250	1.63140	K562	RBM22
PPP1R8	ENSG00000117751.13	1777.07640	1381.67490	0.36300	2.51480	1.73790	K562	RPS19
PPP1R8	ENSG00000117751.13	1607.05500	1341.97440	0.26000	2.28990	1.51490	K562	SF3B4
PPP1R8	ENSG00000117751.13	2454.98860	1690.14760	0.53850	7.94010	6.74850	K562	SRSF1
PPP1R8	ENSG00000117751.13	2040.28760	1463.68040	0.47910	6.59910	5.32230	K562	SYNCRIP
PPP1R8	ENSG00000117751.13	1091.36260	1357.71850	-0.31510	2.28570	1.43900	K562	TRIM56
PPP1R8	ENSG00000117751.13	1571.52480	1291.96650	0.28250	2.52190	1.75530	K562	U2AF2
PPP1R8	ENSG00000117751.13	1495.87990	1845.59860	-0.30310	2.77480	1.89590	K562	WDR3
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

The Knockdown/knockout RNA-Seq assay for PPP1R8 is not available on ENCORE database.

9 RBPs can affect the splicing of PPP1R8 :

Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	2ndExonStart	2ndExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	p-value	FDR	is_included	Cell Line	Affected by RBP
SE	PPP1R8	ENSG00000117751.13	chr1	+	28167524	28167745			28165287	28165363	28169696	28169814	-0.08400	0.00000	0.00000	excluded	K562	AQR
SE	PPP1R8	ENSG00000117751.13	chr1	+	28167524	28167745			28165287	28165363	28169696	28169841	-0.06100	0.00004	0.01307	excluded	K562	EIF3G
A3SS	PPP1R8	ENSG00000117751.13	chr1	+	28165209	28165363			28165287	28165363	28159266	28159327	-0.11900	0.00009	0.07770	shorter	HepG2	LARP4
RI	PPP1R8	ENSG00000117751.13	chr1	+	28176603	28178187			28176603	28176925	28178050	28178187	-0.39500	0.00007	0.00327	excluded	K562	HNRNPC
RI	PPP1R8	ENSG00000117751.13	chr1	+	28176603	28178187			28176603	28176925	28178050	28178187	-0.12800	0.01043	0.09816	excluded	K562	PRPF8
RI	PPP1R8	ENSG00000117751.13	chr1	+	28176603	28178187			28176603	28176925	28178050	28178187	-0.25500	0.01342	0.09734	excluded	K562	AKAP8L
RI	PPP1R8	ENSG00000117751.13	chr1	+	28176603	28178187			28176603	28176925	28178050	28178187	-0.18200	0.00000	0.00000	excluded	K562	AQR
MXE	PPP1R8	ENSG00000117751.13	chr1	+	28159266	28159327	28165209	28165363	28157288	28157402	28167524	28167745	0.10900	0.00573	0.08549	1included	HepG2	SRSF1
MXE	PPP1R8	ENSG00000117751.13	chr1	+	28169696	28169841	28173538	28173603	28167524	28167745	28176603	28176943	-0.10300	0.00105	0.01994	2included	K562	SRSF1
MXE	PPP1R8	ENSG00000117751.13	chr1	+	28169696	28169841	28173538	28173603	28165209	28165363	28176603	28178039	0.12200	0.00000	0.00000	1included	K562	AQR
MXE	PPP1R8	ENSG00000117751.13	chr1	+	28169696	28169841	28173471	28173603	28165209	28165363	28176603	28178039	0.14200	0.00000	0.00000	1included	K562	AQR
MXE	PPP1R8	ENSG00000117751.13	chr1	+	28169696	28169846	28173538	28173603	28165209	28165363	28176603	28178183	0.12000	0.00000	0.00000	1included	K562	AQR
MXE	PPP1R8	ENSG00000117751.13	chr1	+	28169696	28169846	28173471	28173603	28165209	28165363	28176603	28178183	0.14000	0.00000	0.00000	1included	K562	AQR
MXE	PPP1R8	ENSG00000117751.13	chr1	+	28167524	28167745	28169696	28169814	28165287	28165363	28173538	28173603	-0.11600	0.00000	0.00000	2included	K562	AQR
MXE	PPP1R8	ENSG00000117751.13	chr1	+	28167524	28167745	28169696	28169841	28165209	28165363	28173538	28173603	-0.07800	0.01395	0.08266	2included	K562	AQR
MXE	PPP1R8	ENSG00000117751.13	chr1	+	28169696	28169841	28173538	28173603	28167524	28167745	28176603	28176943	-0.07400	0.01442	0.08485	2included	K562	AQR
MXE	PPP1R8	ENSG00000117751.13	chr1	+	28169696	28169846	28173538	28173603	28167524	28167745	28176603	28178183	-0.07400	0.01425	0.08407	2included	K562	AQR
MXE	PPP1R8	ENSG00000117751.13	chr1	+	28169696	28169841	28173538	28173603	28167524	28167745	28176603	28176943	-0.09900	0.00290	0.05964	2included	K562	TARDBP
MXE	PPP1R8	ENSG00000117751.13	chr1	+	28169696	28169841	28173538	28173603	28167524	28167745	28176603	28178187	-0.29200	0.00001	0.00022	2included	HepG2	SFPQ

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

PPP1R8

General Information

Functions

Localization(RBPImage: PPP1R8)

Domains (AlphaFold: PPP1R8)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

eCLIP assay for PPP1R8 is not avaliable on ENCORE database.

35 proteins are bound to PPP1R8 RNA:

eCLIP assay for PPP1R8 is not avaliable on ENCORE database.

Diffrential Expression

942 differentially expressed genes after Knockdown/Knockout PPP1R8 protein :

79 RBPs can affect the gene expression of PPP1R8 :

The Knockdown/knockout RNA-Seq assay for PPP1R8 is not available on ENCORE database.

9 RBPs can affect the splicing of PPP1R8 :

The Knockdown/knockout RNA-Seq assay for PPP1R8 is not avaliable on ENCORE database.