TLE2

General Information

Gene Name       : TLE2
Gene ID             : ENSG00000065717.14
Essential Gene : No

Functions

Localization

Domains (AlphaFold: TLE2)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878TLE2ENSG00000065717.140.000.140.07ENCSR000AEF
HepG2TLE2ENSG00000065717.140.400.100.25ENCSR985KAT
K562TLE2ENSG00000065717.146.384.145.26ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for TLE2 is not avaliable on ENCORE database.



Proteins bound to RNA
  • TLE2 RNA is bound by 3 proteins.  







eCLIP assay for TLE2 is not avaliable on ENCORE database.





3 proteins are bound to TLE2 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr1930250173025054-5'-UTR,CDS,intron-Distal,intron-Proximal4.870764.17466K562DDX24
chr1930287103028777-5'-UTR,CDS,intron-Distal,intron-Proximal5.176485.73530K562DDX24
chr1930286993028752-5'-UTR,CDS,intron-Distal,intron-Proximal3.748653.90826K562ZNF622
chr1930059503006027-CDS,intron-Distal,intron-Proximal3.993204.69223K562SF3B4
chr1930026163002667-intron-Distal5.154166.02529K562SF3B4
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for TLE2 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for TLE2 is not available on ENCORE database.

  • 66 RBPs can affect the levels of TLE2.  








The Knockdown/knockout RNA-Seq assay for TLE2 is not available on ENCORE database.





66 RBPs can affect the gene expression of TLE2 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
TLE2ENSG00000065717.1027.278906.325602.108402.873302.17550HepG2CPSF6
TLE2ENSG00000065717.1033.195009.364201.825602.659402.05380HepG2DDX6
TLE2ENSG00000065717.1018.748503.824602.293302.356601.34000HepG2AGO1
TLE2ENSG00000065717.1032.453208.993601.851302.722502.13460HepG2EIF2S1
TLE2ENSG00000065717.1033.701906.842902.300103.644902.93200HepG2HNRNPLL
TLE2ENSG00000065717.107.2238026.62560-1.882002.451001.67210HepG2LARP4
TLE2ENSG00000065717.1095.6471011.949903.0006014.8178013.34390HepG2PUM2
TLE2ENSG00000065717.102.4884015.69730-2.657202.148301.53680HepG2RPLP0
TLE2ENSG00000065717.102.4041014.31840-2.574302.164101.54000HepG2SRSF7
TLE2ENSG00000065717.1020.920205.576001.907502.079001.63290HepG2TIAL1
TLE2ENSG00000065717.1037.3197013.442401.473002.024301.41070HepG2UPF1
TLE2ENSG00000065717.10320.21900194.278200.720804.380702.81550K562ABCF1
TLE2ENSG00000065717.10852.94340514.907600.7280011.5023010.44030K562AGGF1
TLE2ENSG00000065717.10777.14930565.828800.457703.833602.63690K562AKAP8
TLE2ENSG00000065717.10114.51980295.34400-1.366802.291701.75010K562AQR
TLE2ENSG00000065717.10743.30620562.183900.402803.749402.67310K562ATP5C1
TLE2ENSG00000065717.10181.3444099.641600.863804.253202.56540K562BCCIP
TLE2ENSG00000065717.10177.3328096.295400.880804.350003.12940K562BCLAF1
TLE2ENSG00000065717.10261.63660181.377800.528502.673701.64340K562CCAR1
TLE2ENSG00000065717.10425.45500310.250600.455502.960801.81350K562CPEB4
TLE2ENSG00000065717.10205.10340143.928600.510902.049201.36560K562CPSF6
TLE2ENSG00000065717.10170.9356073.054401.226305.739804.13690K562CSTF2
TLE2ENSG00000065717.10223.15390413.22410-0.888902.874301.88240K562CELF1
TLE2ENSG00000065717.10368.36650228.736200.687405.601503.83880K562DDX21
TLE2ENSG00000065717.10246.8779084.424301.5480015.7911012.93970K562DDX27
TLE2ENSG00000065717.10587.10230263.937701.1533016.2369013.59800K562DDX3X
TLE2ENSG00000065717.10445.12400320.946100.471803.516702.79410K562DDX47
TLE2ENSG00000065717.10371.67960267.594000.473903.087101.68610K562DDX6
TLE2ENSG00000065717.10641.89360155.421302.0461047.1291044.91020K562EIF2S2
TLE2ENSG00000065717.10200.44190275.74350-0.460102.132701.40760K562EIF4A3
TLE2ENSG00000065717.10345.43230248.315900.476103.049401.81950K562EIF4B
TLE2ENSG00000065717.10236.19170139.688000.757604.208003.14670K562FIP1L1
TLE2ENSG00000065717.10271.62380124.117301.129807.900906.27100K562FTO
TLE2ENSG00000065717.1095.19230286.76050-1.5909016.8748015.49320K562FXR1
TLE2ENSG00000065717.1038.6685083.37020-1.108403.114102.35570K562G3BP2
TLE2ENSG00000065717.10204.16840137.418700.571102.284501.56290K562GPKOW
TLE2ENSG00000065717.10448.75010207.097501.1155010.659509.14760K562GRSF1
TLE2ENSG00000065717.10365.68050254.302700.523902.508501.48510K562HNRNPA1
TLE2ENSG00000065717.10246.60030148.750200.729203.722902.38050K562HNRNPF
TLE2ENSG00000065717.10605.02070189.361101.6757025.4557023.28310K562HSPD1
TLE2ENSG00000065717.10263.20930151.916500.792805.256003.51320K562IGF2BP3
TLE2ENSG00000065717.10260.90730148.620500.811803.232101.54710K562LSM11
TLE2ENSG00000065717.10719.90590544.294400.403302.948501.82990K562MAK16
TLE2ENSG00000065717.10899.49000636.964400.497805.067103.76060K562MBNL1
TLE2ENSG00000065717.10420.46440286.342800.554104.460403.45460K562MTPAP
TLE2ENSG00000065717.10400.97390275.355000.542103.573902.15810K562NCBP2
TLE2ENSG00000065717.10255.22580164.037300.637702.881101.41750K562NUSAP1
TLE2ENSG00000065717.10370.04260245.146000.593902.449501.30700K562PABPC1
TLE2ENSG00000065717.10535.23230297.065800.849303.788802.57900K562PABPN1
TLE2ENSG00000065717.10247.75050158.600400.643403.173302.28570K562PPIG
TLE2ENSG00000065717.10659.76590353.231100.901203.992502.12250K562PPP1R8
TLE2ENSG00000065717.1057.09460104.34790-0.870002.569801.84650K562PRPF8
TLE2ENSG00000065717.10354.06410149.300401.2457010.832008.78640K562PSIP1
TLE2ENSG00000065717.10168.12540366.40450-1.123903.116302.25270K562PUF60
TLE2ENSG00000065717.10884.96040381.846701.212509.956508.11750K562PUM2
TLE2ENSG00000065717.10224.52310153.755800.546102.400701.39640K562NELFE
TLE2ENSG00000065717.10275.95140106.246301.376908.972007.48780K562RPS19
TLE2ENSG00000065717.10331.09370220.920400.583602.635701.66020K562RPS3
TLE2ENSG00000065717.10565.13950271.705301.056504.431102.79820K562SF1
TLE2ENSG00000065717.10250.23010129.208300.953504.288602.93120K562SRFBP1
TLE2ENSG00000065717.10346.66520213.219300.701104.245502.89810K562SRSF4
TLE2ENSG00000065717.10294.22980141.186801.059208.465106.53040K562SRSF5
TLE2ENSG00000065717.1079.32110234.71120-1.565108.114506.70000K562SYNCRIP
TLE2ENSG00000065717.10293.28670145.880801.007406.192504.89670K562TIA1
TLE2ENSG00000065717.10305.10700143.590801.087305.602304.22640K562TIAL1
TLE2ENSG00000065717.10236.36780152.649700.630702.754501.81230K562TRIM56
TLE2ENSG00000065717.10265.58040163.304100.701503.103301.61830K562TRIP6
TLE2ENSG00000065717.1040.3481083.42570-1.048003.266202.39510K562U2AF2
TLE2ENSG00000065717.10963.23750337.317701.5137043.4290041.02130K562UPF1
TLE2ENSG00000065717.10420.68670300.164000.486903.859902.87210K562WDR43
TLE2ENSG00000065717.10206.79000108.901100.925003.224701.88440K562XRN2
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for TLE2 is not available on ENCORE database.





4 RBPs can affect the splicing of TLE2 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SETLE2ENSG00000065717.10chr19-301783730178573015650301575830192803019771-0.179000.005850.07007excludedK562PUS1
SETLE2ENSG00000065717.10chr19-301783730178573015650301575830192803019771-0.138000.000190.02060excludedK562HNRNPUL1
A3SSTLE2ENSG00000065717.10chr19-3009539300973530095393009700301101930111580.051000.020610.09783longerK562AQR
RITLE2ENSG00000065717.10chr19-301928030197713019280301946430196963019771-0.293000.011840.09640excludedK562RBM15

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for TLE2 is not avaliable on ENCORE database.