SIRT2

General Information

Gene Name       : SIRT2
Gene ID             : ENSG00000068903.19
Essential Gene : No

Functions

Localization

Domains (AlphaFold: SIRT2)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878SIRT2ENSG00000068903.1910.2617.2713.77ENCSR000AEF
HepG2SIRT2ENSG00000068903.1915.6711.6013.63ENCSR985KAT
K562SIRT2ENSG00000068903.1923.5523.6723.61ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for SIRT2 is not avaliable on ENCORE database.



Proteins bound to RNA
  • SIRT2 RNA is bound by 11 proteins.  







eCLIP assay for SIRT2 is not avaliable on ENCORE database.





11 proteins are bound to SIRT2 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr193936923339369303-3'-UTR,intron-Distal5.4563710.00893K562UPF1
chr193937973339379794-3'-UTR,CDS,intron-Distal,intron-Proximal3.576883.01531K562YBX3
chr193936943139369519-3'-UTR,intron-Distal3.474638.70859K562QKI
chr193936937239369599-3'-UTR,intron-Distal5.5201326.20392K562UPF1
chr193936940039369488-3'-UTR,intron-Distal3.986057.88838K562IGF2BP2
chr193937201139372079-3'-UTR,CDS,intron-Distal,intron-Proximal4.932626.04760K562AQR
chr193938405339384126-5'-UTR,CDS,intron-Distal,intron-Proximal4.267184.38106HepG2PPIG
chr193937127439371327-CDS,intron-Distal,intron-Proximal4.932626.04760K562AQR
chr193938916539389227-intron-Distal3.732123.06617K562HNRNPK
chr193938991339390064-intron-Distal3.109326.26922K562CSTF2T
chr193938435639384413-intron-Distal,intron-Proximal4.538673.62536K562AQR
chr193938428739384383-intron-Distal,intron-Proximal4.195566.40042K562EFTUD2
chr193938577839385886-intron-Distal3.997873.86417HepG2PRPF4
chr193938987039390030-intron-Distal4.229264.33692K562NONO
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for SIRT2 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for SIRT2 is not available on ENCORE database.

  • 113 RBPs can affect the levels of SIRT2.  








The Knockdown/knockout RNA-Seq assay for SIRT2 is not available on ENCORE database.





113 RBPs can affect the gene expression of SIRT2 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
SIRT2ENSG00000068903.15903.31710636.221000.505602.943601.96930HepG2ABCF1
SIRT2ENSG00000068903.15662.73280853.20280-0.364501.869501.42250HepG2AKAP1
SIRT2ENSG00000068903.15842.63890566.316400.573207.720206.66590HepG2AUH
SIRT2ENSG00000068903.15478.69180303.110500.659202.124901.33270HepG2BCLAF1
SIRT2ENSG00000068903.15733.07470302.685001.2760018.9576017.59900HepG2BOP1
SIRT2ENSG00000068903.151219.59230670.690500.8626010.813609.37760HepG2CIRBP
SIRT2ENSG00000068903.15681.67970525.500500.375303.470902.65820HepG2DAZAP1
SIRT2ENSG00000068903.15561.00560413.370200.440504.398303.37660HepG2DDX19B
SIRT2ENSG00000068903.15517.41580344.328500.587404.334703.50580HepG2DDX21
SIRT2ENSG00000068903.151141.92660817.255600.482503.647302.93910HepG2DDX3X
SIRT2ENSG00000068903.15648.05140476.738900.442803.026401.67360HepG2DDX47
SIRT2ENSG00000068903.15677.23640480.620300.494703.620702.47050HepG2DDX5
SIRT2ENSG00000068903.15523.70890702.15280-0.423002.297301.72970HepG2DDX6
SIRT2ENSG00000068903.15510.63770285.527400.838608.151606.56080HepG2DHX30
SIRT2ENSG00000068903.15764.64410427.636300.8383013.1242011.87270HepG2DKC1
SIRT2ENSG00000068903.15427.73740296.047000.530802.329201.67780HepG2DNAJC21
SIRT2ENSG00000068903.15429.04290293.391500.548205.043904.20490HepG2DNAJC2
SIRT2ENSG00000068903.151110.60990745.771700.574404.465803.65630HepG2EIF4A3
SIRT2ENSG00000068903.15453.05050726.21730-0.680704.259703.41650HepG2EIF4B
SIRT2ENSG00000068903.15845.45480496.616900.767508.317206.93890HepG2EIF4G2
SIRT2ENSG00000068903.15467.97100314.978600.571103.200502.51640HepG2GPKOW
SIRT2ENSG00000068903.15467.94780298.882700.646704.665703.85600HepG2HNRNPA1
SIRT2ENSG00000068903.15495.75820332.438100.576503.862903.05460HepG2HNRNPC
SIRT2ENSG00000068903.15604.84250437.954300.465704.266903.39710HepG2HNRNPF
SIRT2ENSG00000068903.15588.60030478.697100.298102.166601.55980HepG2HNRNPL
SIRT2ENSG00000068903.15605.68230300.591301.0107010.318009.19290HepG2HNRNPLL
SIRT2ENSG00000068903.15494.39180330.241200.582005.577004.74080HepG2HNRNPU
SIRT2ENSG00000068903.15695.65570431.259000.689707.588606.44620HepG2IGF2BP1
SIRT2ENSG00000068903.151220.25030709.548300.782109.074107.92960HepG2IGF2BP2
SIRT2ENSG00000068903.15453.61750337.332800.427203.449102.63730HepG2ILF2
SIRT2ENSG00000068903.15453.46090306.597300.564502.477701.56430HepG2MTPAP
SIRT2ENSG00000068903.151041.85710774.879000.427002.836202.19500HepG2NCBP2
SIRT2ENSG00000068903.15562.23890327.179700.781004.215403.10320HepG2PABPC1
SIRT2ENSG00000068903.15488.39080294.551100.729407.638306.45980HepG2PPIL4
SIRT2ENSG00000068903.15544.93680797.62450-0.549606.468005.70020HepG2PTBP1
SIRT2ENSG00000068903.15672.28950497.414600.434503.102602.47740HepG2PUF60
SIRT2ENSG00000068903.15677.01580455.287700.572307.110106.20030HepG2PUS1
SIRT2ENSG00000068903.15691.76740863.81810-0.320402.412001.82230HepG2QKI
SIRT2ENSG00000068903.15209.57170328.82670-0.649902.409201.74840HepG2RAVER1
SIRT2ENSG00000068903.15611.18070887.66820-0.538406.563205.78980HepG2NELFE
SIRT2ENSG00000068903.15551.14860826.76280-0.585007.410206.47470HepG2RECQL
SIRT2ENSG00000068903.15935.69820471.798900.9878013.8250012.51460HepG2RPLP0
SIRT2ENSG00000068903.15584.90750323.202200.855705.754904.42120HepG2RPS10
SIRT2ENSG00000068903.15492.81930296.733600.731806.165005.28890HepG2RPS19
SIRT2ENSG00000068903.15508.39640359.662400.499202.329901.59360HepG2RPS3A
SIRT2ENSG00000068903.15410.69210261.579700.650702.785401.99650HepG2RRP9
SIRT2ENSG00000068903.15412.86800294.102500.489303.758703.02770HepG2SAFB2
SIRT2ENSG00000068903.15520.37930297.770400.805306.451905.03330HepG2SERBP1
SIRT2ENSG00000068903.15399.47830192.606701.052402.887501.49650HepG2SF1
SIRT2ENSG00000068903.15561.86350297.517200.917104.467503.58810HepG2SF3B1
SIRT2ENSG00000068903.15595.64220830.40570-0.479405.204404.43670HepG2SF3B4
SIRT2ENSG00000068903.15665.68100476.929000.481005.231404.31650HepG2SLBP
SIRT2ENSG00000068903.15431.02840342.986800.329502.158601.57890HepG2SMN1
SIRT2ENSG00000068903.15334.57290172.240100.957802.685001.40110HepG2SNRNP200
SIRT2ENSG00000068903.15200.32270331.04320-0.724703.144602.31000HepG2SNRNP70
SIRT2ENSG00000068903.15748.40510613.801900.285902.524602.03830HepG2SRFBP1
SIRT2ENSG00000068903.15580.55670866.77370-0.578207.671106.97550HepG2SRSF1
SIRT2ENSG00000068903.15641.35710430.279100.575806.431905.44180HepG2SRSF7
SIRT2ENSG00000068903.15405.06990705.17510-0.7998012.5066011.48220HepG2SRSF9
SIRT2ENSG00000068903.15306.89020532.94040-0.796309.652508.80810HepG2SSB
SIRT2ENSG00000068903.15548.98210341.496000.684803.102902.39090HepG2SUPV3L1
SIRT2ENSG00000068903.15551.01110779.11760-0.499804.962604.24650HepG2TAF15
SIRT2ENSG00000068903.15524.09590293.023800.838707.506706.38880HepG2TARDBP
SIRT2ENSG00000068903.151134.61330320.942401.8217053.6733051.99960HepG2TIAL1
SIRT2ENSG00000068903.15504.99500323.756200.641306.842806.02420HepG2TRIM56
SIRT2ENSG00000068903.15465.51970200.213401.217203.218502.15430HepG2U2AF2
SIRT2ENSG00000068903.15684.28150514.354400.411702.096801.37400HepG2UBE2L3
SIRT2ENSG00000068903.15822.70460584.088600.494106.201505.22310HepG2UPF1
SIRT2ENSG00000068903.15529.54280312.533000.760602.301401.39260HepG2UPF2
SIRT2ENSG00000068903.15493.81470322.168900.616102.430401.41250HepG2XPO5
SIRT2ENSG00000068903.15529.52020336.167300.655402.424401.74220HepG2XRN2
SIRT2ENSG00000068903.15621.19260423.846900.551406.295405.34950HepG2ZC3H8
SIRT2ENSG00000068903.151122.27740642.385200.8048019.8350018.70090HepG2ZNF622
SIRT2ENSG00000068903.151316.861801102.350500.256402.584902.03220K562AGGF1
SIRT2ENSG00000068903.151760.095301211.329300.539006.566304.88830K562AKAP8
SIRT2ENSG00000068903.151193.97270827.558000.528704.967204.22220K562AQR
SIRT2ENSG00000068903.15620.90240498.494900.316702.384701.49490K562BCLAF1
SIRT2ENSG00000068903.15816.21960514.876100.664605.942104.65210K562BOP1
SIRT2ENSG00000068903.151628.193601317.359100.305502.895501.68630K562CCDC124
SIRT2ENSG00000068903.151228.75540921.905200.414402.783601.34870K562CKAP4
SIRT2ENSG00000068903.151030.02260658.285500.645803.550902.32080K562CNOT7
SIRT2ENSG00000068903.15835.68200547.457700.610106.521105.31530K562CPSF6
SIRT2ENSG00000068903.151225.29780827.830700.565609.156008.05500K562DDX47
SIRT2ENSG00000068903.15713.32560554.242500.363902.972601.60040K562DDX6
SIRT2ENSG00000068903.15671.18130419.855600.676705.007103.76180K562EFTUD2
SIRT2ENSG00000068903.15832.28670682.415800.286302.279701.61740K562EIF2S2
SIRT2ENSG00000068903.15733.57150500.436500.551702.480201.53090K562EIF3A
SIRT2ENSG00000068903.15668.92200449.354700.573903.438702.27530K562EIF3D
SIRT2ENSG00000068903.15449.79220315.654500.510803.622702.72000K562EIF3G
SIRT2ENSG00000068903.151263.317401056.211800.258202.287901.43000K562EIF4G2
SIRT2ENSG00000068903.15914.47920638.669100.517805.077603.31000K562EXOSC5
SIRT2ENSG00000068903.15894.51170591.026900.597805.926204.65070K562FIP1L1
SIRT2ENSG00000068903.15848.81230557.031700.607605.530404.31290K562FMR1
SIRT2ENSG00000068903.15656.73350472.137400.476002.243201.42500K562FTO
SIRT2ENSG00000068903.15158.23070321.76120-1.024003.049902.30100K562G3BP2
SIRT2ENSG00000068903.15821.29200659.975200.315402.556401.46230K562GLRX3
SIRT2ENSG00000068903.15827.41170522.684700.662606.757205.51870K562GPKOW
SIRT2ENSG00000068903.151142.94470909.409900.329702.475501.75840K562GRSF1
SIRT2ENSG00000068903.151082.61770636.029400.767303.450502.04320K562HNRNPA2B1
SIRT2ENSG00000068903.15951.57190748.110800.347002.673801.63870K562HNRNPL
SIRT2ENSG00000068903.151033.50240801.229100.367202.693901.90880K562HSPD1
SIRT2ENSG00000068903.15702.86830503.969600.479803.919602.44930K562IGF2BP3
SIRT2ENSG00000068903.151504.455701217.294400.305502.855002.01470K562KIF1C
SIRT2ENSG00000068903.151494.858801165.259200.359303.307502.10080K562MAK16
SIRT2ENSG00000068903.15728.98650570.317400.354002.536101.36300K562NCBP2
SIRT2ENSG00000068903.151000.37950770.931700.375804.936403.97950K562NSUN2
SIRT2ENSG00000068903.151125.00160632.425100.830905.581403.81050K562PABPC1
SIRT2ENSG00000068903.151089.21450556.169400.969605.268703.77920K562PABPN1
SIRT2ENSG00000068903.151089.34730812.379800.423102.244501.49620K562PCBP3
SIRT2ENSG00000068903.15827.40130623.075200.409103.071502.22640K562POLR2G
SIRT2ENSG00000068903.151283.06610661.050300.956704.706802.63270K562PPP1R8
SIRT2ENSG00000068903.15669.01910513.620100.381202.196601.39860K562PSIP1
SIRT2ENSG00000068903.151319.960601108.375300.251902.164101.62850K562RBM15
SIRT2ENSG00000068903.151228.78460684.216400.844603.717001.86400K562RBM39
SIRT2ENSG00000068903.15743.49490416.044000.837507.040405.72230K562RPS19
SIRT2ENSG00000068903.15926.48700508.529500.865303.223201.89940K562SF1
SIRT2ENSG00000068903.15948.08730760.766400.317502.802201.98300K562SF3A3
SIRT2ENSG00000068903.15704.00600497.101500.501903.170402.12700K562SF3B1
SIRT2ENSG00000068903.151050.46890619.805900.761003.077501.67020K562SFPQ
SIRT2ENSG00000068903.15988.47810584.173000.758703.004701.70570K562SNRNP200
SIRT2ENSG00000068903.15659.87820444.367100.570304.500503.10460K562SRFBP1
SIRT2ENSG00000068903.15651.27900468.389300.475503.481102.27960K562SRSF5
SIRT2ENSG00000068903.151376.44500698.653800.978204.905302.80940K562SUPT6H
SIRT2ENSG00000068903.15605.93600484.055300.323902.032401.33760K562TIA1
SIRT2ENSG00000068903.15925.18080493.997100.9051010.350608.44070K562TIAL1
SIRT2ENSG00000068903.15869.24550524.987400.727407.887506.09710K562TRIM56
SIRT2ENSG00000068903.151071.38170817.438100.390204.839003.91720K562UPF1
SIRT2ENSG00000068903.15946.89980699.451300.436904.032702.97040K562WDR3
SIRT2ENSG00000068903.151004.57790727.380200.465706.731805.46650K562WDR43
SIRT2ENSG00000068903.151159.41570687.364000.754203.098601.39560K562YTHDC2
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for SIRT2 is not available on ENCORE database.





16 RBPs can affect the splicing of SIRT2 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SESIRT2ENSG00000068903.15chr19-3938901839389065393844583938461139390145393904630.439000.000110.03690includedK562PUM1
SESIRT2ENSG00000068903.15chr19-3938901839389065393844583938450739390145393904630.238000.000000.00005includedK562FXR1
SESIRT2ENSG00000068903.15chr19-393890183938906539384458393845073939014539390463-0.195000.000120.02716excludedK562NSUN2
SESIRT2ENSG00000068903.15chr19-3937989339379963393797263937979539380328393803850.058000.000880.04622includedHepG2PTBP1
SESIRT2ENSG00000068903.15chr19-3938901839389065393844583938450739390145393904630.140000.000060.01934includedK562APOBEC3C
SESIRT2ENSG00000068903.15chr19-3938901839389065393844583938450739390145393904630.257000.000200.02859includedHepG2LARP4
SESIRT2ENSG00000068903.15chr19-393890183938906539384458393846113939014539390353-0.308000.000380.06142excludedHepG2RBM15
SESIRT2ENSG00000068903.15chr19-3938901839389065393844583938461139390145393904630.445000.000080.06623includedHepG2PPIG
SESIRT2ENSG00000068903.15chr19-3937989339379963393797263937979539380328393803850.059000.001440.03424includedHepG2SRSF1
SESIRT2ENSG00000068903.15chr19-3938901839389065393844583938450739390145393904630.115000.000120.07516includedK562PUM2
SESIRT2ENSG00000068903.15chr19-3938901839389065393844583938450739390145393904630.136000.000540.02970includedHepG2PCBP1
SESIRT2ENSG00000068903.15chr19-3937989339379963393797263937979539380328393803850.137000.002460.04130includedK562U2AF2
SESIRT2ENSG00000068903.15chr19-3938901839389065393844583938450739390145393904630.175000.000450.02145includedK562PTBP1
SESIRT2ENSG00000068903.15chr19-3938120439381302393807423938078439384053393841670.118000.000250.00596includedK562HNRNPC
A3SSSIRT2ENSG00000068903.15chr19-3937027139370443393702713937034239371324393714890.155000.000270.02577longerHepG2SF3A3
A3SSSIRT2ENSG00000068903.15chr19-3938445839384690393844583938450739390145393903180.099000.000410.00316longerK562AQR
RISIRT2ENSG00000068903.15chr19-3937132439371489393713243937137639371460393714890.067000.000760.01016includedK562RBM15
RISIRT2ENSG00000068903.15chr19-3937132439371489393713243937137639371460393714890.056000.002250.02808includedK562UTP18
RISIRT2ENSG00000068903.15chr19-3937132439371489393713243937137639371460393714890.069000.000340.00253includedK562AQR

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for SIRT2 is not avaliable on ENCORE database.