PNPLA3

General Information

Gene Name       : PNPLA3
Gene ID             : ENSG00000100344.10
Essential Gene : No

Functions

Localization

Domains (AlphaFold: PNPLA3)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878PNPLA3ENSG00000100344.100.000.000.00ENCSR000AEF
HepG2PNPLA3ENSG00000100344.1018.629.8514.23ENCSR985KAT
K562PNPLA3ENSG00000100344.100.040.320.18ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for PNPLA3 is not avaliable on ENCORE database.



Proteins bound to RNA
  • PNPLA3 RNA is bound by 29 proteins.  







eCLIP assay for PNPLA3 is not avaliable on ENCORE database.





29 proteins are bound to PNPLA3 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr224434246944342523+3'-UTR,intron-Distal4.600755.04923HepG2AKAP1
chr224434259344342738+3'-UTR,intron-Distal4.2072520.56330HepG2AKAP1
chr224434257144342640+3'-UTR,intron-Distal4.2679015.91272HepG2UPF1
chr224434058644340671+3'-UTR,CDS3.8058411.17337HepG2PPIG
chr224434264044342737+3'-UTR,intron-Distal3.7006513.90623HepG2UPF1
chr224434326344343317+3'-UTR,intron-Distal3.732617.44034HepG2AKAP1
chr224434292744343017+3'-UTR,intron-Distal4.0116716.90696HepG2UPF1
chr224434047544340586+3'-UTR,CDS,intron-Proximal3.006953.45218HepG2KHSRP
chr224434065044340677+3'-UTR,CDS,intron-Proximal3.760538.43093HepG2PRPF8
chr224434054144340594+3'-UTR,CDS,intron-Proximal3.216227.92183HepG2BUD13
chr224434260344342723+3'-UTR,intron-Distal3.127955.04573HepG2KHSRP
chr224434233244342375+3'-UTR,intron-Distal3.513214.26759HepG2AKAP1
chr224434337344343402+3'-UTR,intron-Distal3.043803.20756HepG2UPF1
chr224435916144359216+3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal3.930533.79347HepG2GRWD1
chr224434051644340587+3'-UTR,CDS,intron-Proximal4.725575.68078HepG2AQR
chr224433043744330495+5'-UTR,CDS,intron-Proximal4.422564.92499HepG2AQR
chr224433304144333092+5'-UTR,CDS3.007554.23325HepG2BCLAF1
chr224433048544330547+5'-UTR,CDS,intron-Proximal3.258648.88472HepG2PPIG
chr224433053144330588+5'-UTR,CDS,intron-Proximal4.420679.00124HepG2PRPF8
chr224433292744333000+5'-UTR,CDS,intron-Proximal3.5687413.88807HepG2PPIG
chr224433292244332959+5'-UTR,CDS,intron-Proximal3.447863.16095HepG2U2AF2
chr224431968044319737+5'-UTR4.018647.13336HepG2NCBP2
chr224433311644333196+5'-UTR,CDS,intron-Proximal3.500067.45900HepG2PRPF8
chr224433297244333010+5'-UTR,CDS3.627824.25541HepG2GRWD1
chr224433045044330515+5'-UTR,CDS,intron-Proximal4.7103020.23438HepG2U2AF2
chr224433307944333152+5'-UTR,CDS3.3180115.58494HepG2PPIG
chr224431973744319788+5'-UTR3.516584.35138HepG2NCBP2
chr224432891444328978+5'-UTR,CDS,intron-Proximal3.4482911.11753HepG2PPIG
chr224432886644328939+5'-UTR,CDS3.6833010.52463HepG2GRWD1
chr224432475844324826+5'-UTR,CDS,intron-Proximal3.174026.93483HepG2PRPF8
chr224433301344333092+5'-UTR,CDS4.4331714.87701HepG2GRWD1
chr224433587244335890+5'-UTR,CDS,intron-Proximal3.444764.25541HepG2GRWD1
chr224433302044333104+5'-UTR,CDS3.308597.02296HepG2SRSF1
chr224433287044332955+5'-UTR,CDS,intron-Proximal3.583313.57857HepG2SF3B4
chr224433302244333079+5'-UTR,CDS4.1950912.11762HepG2PPIG
chr224433592644335987+5'-UTR,CDS3.406384.61799HepG2BCLAF1
chr224433311444333151+5'-UTR,CDS4.438669.60942HepG2GRWD1
chr224433598644336058+5'-UTR,CDS,intron-Proximal4.133949.38298HepG2PRPF8
chr224432875844328799+5'-UTR,CDS3.419607.20311HepG2PPIG
chr224432877044328863+5'-UTR,CDS3.009773.85159HepG2UCHL5
chr224433046644330511+5'-UTR,CDS,intron-Proximal3.441505.76899HepG2EFTUD2
chr224432279544322843+CDS,intron-Proximal4.272783.93614HepG2AQR
chr224434204144342111+CDS,intron-Distal4.114343.99014HepG2PABPN1
chr224432149744321563+intron-Distal3.096943.40641HepG2GTF2F1
chr224433984944339880+intron-Distal3.985843.79098HepG2SUGP2
chr224435133744351479+5'-UTR,CDS,intron-Distal,intron-Proximal5.2984412.19987K562DDX3X
chr224433908044339211+intron-Distal3.1965712.47331HepG2PTBP1
chr224433723544337311+intron-Distal3.357953.10961HepG2MATR3
chr224432002644320136+intron-Distal,intron-Proximal3.098386.22348HepG2RBFOX2
chr224433893044338980+intron-Distal3.439705.12973HepG2MATR3
chr224432217344322264+intron-Distal3.156287.16815HepG2RBFOX2
chr224433916844339223+intron-Distal4.2632116.69254HepG2MATR3
chr224434548444345536+intron-Distal3.139413.40404HepG2ILF3
chr224433890144338988+intron-Distal4.460748.54919HepG2PTBP1
chr224434610844346159+intron-Distal4.672055.45170HepG2AKAP1
chr224434441144344513+intron-Distal3.374258.33507HepG2PTBP1
chr224434723144347325+intron-Distal3.575747.50798HepG2ZC3H11A
chr224433884544338874+intron-Distal3.007734.23155HepG2MATR3
chr224434601844346138+intron-Distal3.9004314.63268HepG2UPF1
chr224433155844331635+intron-Distal3.050394.79706HepG2PRPF4
chr224432085044320904+intron-Distal6.2914911.82752HepG2XPO5
chr224432006144320154+intron-Distal,intron-Proximal4.519424.19473HepG2FKBP4
chr224434618744346278+intron-Distal3.513459.54397HepG2UPF1
chr224433718144337281+intron-Distal3.252243.90917HepG2PRPF4
chr224433968844339719+intron-Distal4.394734.32882HepG2MATR3
chr224433163744331717+intron-Distal3.856936.98486HepG2PRPF4
chr224433818044338207+intron-Distal3.199933.35050HepG2SUGP2
chr224433909144339168+intron-Distal4.1075414.64902HepG2MATR3
chr224434067644340733+intron-Proximal3.317494.28981HepG2RBM22
chr224432477344324865+intron-Proximal4.244364.01760HepG2TIAL1
chr224434067744340723+intron-Proximal3.5980817.85496HepG2PRPF8
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for PNPLA3 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for PNPLA3 is not available on ENCORE database.

  • 112 RBPs can affect the levels of PNPLA3.  








The Knockdown/knockout RNA-Seq assay for PNPLA3 is not available on ENCORE database.





112 RBPs can affect the gene expression of PNPLA3 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
PNPLA3ENSG00000100344.6189.03810417.95680-1.144703.541602.33680HepG2AATF
PNPLA3ENSG00000100344.6279.94430682.70940-1.2861028.1066026.64310HepG2ACO1
PNPLA3ENSG00000100344.6449.37340319.018800.494202.947001.91970HepG2ADAR
PNPLA3ENSG00000100344.6128.976001205.16180-3.2241079.6904077.48880HepG2AKAP1
PNPLA3ENSG00000100344.6262.19170488.33720-0.897306.907405.38860HepG2BCCIP
PNPLA3ENSG00000100344.6657.16230424.290900.631104.096303.02180HepG2BCLAF1
PNPLA3ENSG00000100344.6180.61150258.41240-0.516802.278901.73000HepG2BOP1
PNPLA3ENSG00000100344.6448.36150340.508500.396902.240601.54160HepG2CALR
PNPLA3ENSG00000100344.6865.04680682.467500.341903.689702.94140HepG2CKAP4
PNPLA3ENSG00000100344.6573.34300237.233401.2730015.4779014.01070HepG2CPSF6
PNPLA3ENSG00000100344.6191.99030301.59110-0.651603.790502.55190HepG2CSTF2
PNPLA3ENSG00000100344.6309.23720573.69900-0.8916011.8109010.66100HepG2CELF1
PNPLA3ENSG00000100344.6934.98910616.891900.5998010.078108.80280HepG2DAZAP1
PNPLA3ENSG00000100344.6212.24900327.60430-0.626203.010101.80600HepG2DDX1
PNPLA3ENSG00000100344.6645.31670460.217600.487602.440801.79970HepG2DDX21
PNPLA3ENSG00000100344.6680.02620451.117300.592003.260002.26550HepG2DDX24
PNPLA3ENSG00000100344.6834.128301154.48690-0.468903.460402.77030HepG2DDX3X
PNPLA3ENSG00000100344.6214.28270306.40840-0.515902.817301.45050HepG2DDX52
PNPLA3ENSG00000100344.6201.32260480.15560-1.2540011.9284010.45880HepG2DDX55
PNPLA3ENSG00000100344.6757.64300507.990400.576604.855003.53990HepG2DDX5
PNPLA3ENSG00000100344.6325.90870991.65030-1.6054024.6441023.06960HepG2DDX6
PNPLA3ENSG00000100344.6579.97660309.830800.904409.998708.26710HepG2DHX30
PNPLA3ENSG00000100344.61129.98470653.143700.7907015.4745014.14800HepG2DKC1
PNPLA3ENSG00000100344.6314.32450454.86760-0.533203.546902.21990HepG2EIF2S2
PNPLA3ENSG00000100344.6181.87180296.73270-0.706203.627602.59980HepG2EIF3D
PNPLA3ENSG00000100344.62043.806201053.628500.9558012.7920011.44480HepG2EIF4A3
PNPLA3ENSG00000100344.6708.629101025.78390-0.533603.160102.42820HepG2EIF4B
PNPLA3ENSG00000100344.6816.67960582.985000.486203.079502.22230HepG2EIF4G2
PNPLA3ENSG00000100344.6630.03760849.30490-0.430804.484503.75300HepG2ETF1
PNPLA3ENSG00000100344.6188.32860605.69390-1.685309.454608.14220HepG2FIP1L1
PNPLA3ENSG00000100344.6501.86870237.646701.078404.625003.31830HepG2FTO
PNPLA3ENSG00000100344.6255.74570561.33030-1.134109.635007.71440HepG2FUS
PNPLA3ENSG00000100344.6725.972501062.95400-0.550104.677903.79410HepG2FXR1
PNPLA3ENSG00000100344.61448.094101046.799300.468103.992702.91510HepG2G3BP2
PNPLA3ENSG00000100344.6761.67280268.913701.5019016.7353015.28660HepG2GPKOW
PNPLA3ENSG00000100344.6343.73230529.10360-0.622303.211101.50890HepG2GTF2F1
PNPLA3ENSG00000100344.6352.32640651.73530-0.8874014.5742012.62500HepG2HDGF
PNPLA3ENSG00000100344.6329.21970538.28050-0.709303.506301.92480HepG2HLTF
PNPLA3ENSG00000100344.6173.35470281.56390-0.699703.274901.78560HepG2HNRNPA0
PNPLA3ENSG00000100344.6911.09980324.310601.4901027.9341026.28180HepG2HNRNPA1
PNPLA3ENSG00000100344.6439.23320566.92950-0.368202.828201.88550HepG2HNRNPA2B1
PNPLA3ENSG00000100344.6514.49040360.738200.512103.245002.50020HepG2HNRNPC
PNPLA3ENSG00000100344.6447.04250265.700000.750507.413206.31190HepG2HNRNPF
PNPLA3ENSG00000100344.6517.88830998.38190-0.9470012.3798011.00590HepG2HNRNPK
PNPLA3ENSG00000100344.6308.74540561.94880-0.8640012.4760011.13960HepG2HNRNPL
PNPLA3ENSG00000100344.61021.60890256.630101.9930042.3537040.35230HepG2HNRNPLL
PNPLA3ENSG00000100344.6237.99470358.35300-0.590504.621603.85480HepG2HNRNPU
PNPLA3ENSG00000100344.6606.12280261.635901.2119010.092608.79250HepG2IGF2BP1
PNPLA3ENSG00000100344.61652.522901002.375500.721108.397307.28810HepG2IGF2BP2
PNPLA3ENSG00000100344.6651.33820476.897000.449602.307701.55510HepG2LARP4
PNPLA3ENSG00000100344.6172.48230408.91900-1.2454012.6742010.39540HepG2LARP7
PNPLA3ENSG00000100344.61642.422101063.324600.627106.478805.48590HepG2MAGOH
PNPLA3ENSG00000100344.6203.00080346.35050-0.770705.000002.87710HepG2MARK2
PNPLA3ENSG00000100344.6682.930201069.29420-0.646805.348804.49670HepG2MATR3
PNPLA3ENSG00000100344.6126.68070310.54610-1.293607.352405.72730HepG2METAP2
PNPLA3ENSG00000100344.6277.86820489.95940-0.818305.221704.13780HepG2MSI2
PNPLA3ENSG00000100344.6386.24350261.748700.561202.329301.44580HepG2MTPAP
PNPLA3ENSG00000100344.6285.55610611.70740-1.0991016.5546014.78270HepG2NOL12
PNPLA3ENSG00000100344.6739.52540227.558101.7003028.2060026.23460HepG2NSUN2
PNPLA3ENSG00000100344.61664.78980974.789700.772109.346308.03860HepG2PABPC4
PNPLA3ENSG00000100344.6101.35110354.70480-1.8073025.6049023.55320HepG2PARN
PNPLA3ENSG00000100344.61141.74340965.128700.242302.108501.56680HepG2PCBP1
PNPLA3ENSG00000100344.6339.36980531.35910-0.646803.589302.41470HepG2PCBP2
PNPLA3ENSG00000100344.6901.26200413.709201.1232025.2738023.38500HepG2PRPF4
PNPLA3ENSG00000100344.6377.55610558.56950-0.565002.813401.58630HepG2PRPF6
PNPLA3ENSG00000100344.6256.83750466.76610-0.861803.777101.70350HepG2PSIP1
PNPLA3ENSG00000100344.6743.50100982.03810-0.401404.756104.08110HepG2PTBP1
PNPLA3ENSG00000100344.6946.97780583.921400.697504.438003.70370HepG2PUF60
PNPLA3ENSG00000100344.6168.62060619.85040-1.8781047.8292045.98240HepG2PUM1
PNPLA3ENSG00000100344.61385.59300695.370100.9946029.6870028.06020HepG2PUS1
PNPLA3ENSG00000100344.6617.540801063.60650-0.7844012.5455011.35710HepG2QKI
PNPLA3ENSG00000100344.6236.38510512.70800-1.117006.792505.71380HepG2RAVER1
PNPLA3ENSG00000100344.6258.90940731.74250-1.4989029.4229027.15280HepG2RBM15
PNPLA3ENSG00000100344.6318.16250709.86270-1.1578019.8460018.71940HepG2RBM22
PNPLA3ENSG00000100344.61188.78930965.278000.300402.236301.62430HepG2RBM25
PNPLA3ENSG00000100344.6563.78610400.400000.493602.745501.68880HepG2RCC2
PNPLA3ENSG00000100344.6713.821301092.92780-0.614609.660008.76000HepG2NELFE
PNPLA3ENSG00000100344.6606.656901017.88900-0.7466013.1913011.99490HepG2RECQL
PNPLA3ENSG00000100344.6189.50190288.75100-0.607603.380802.71000HepG2RPS19
PNPLA3ENSG00000100344.6607.96940334.317800.862706.447205.23020HepG2RPS3A
PNPLA3ENSG00000100344.6293.37490464.19850-0.662004.503303.11540HepG2RPS5
PNPLA3ENSG00000100344.6177.50300366.29470-1.045207.696206.46930HepG2RRP9
PNPLA3ENSG00000100344.6192.32180319.12760-0.730605.885905.00100HepG2SAFB2
PNPLA3ENSG00000100344.6559.588501065.87630-0.929605.707804.71810HepG2SF3A3
PNPLA3ENSG00000100344.61024.07600559.873200.8711020.0087018.45760HepG2SLBP
PNPLA3ENSG00000100344.6293.24280372.15410-0.343802.109201.53660HepG2SMN1
PNPLA3ENSG00000100344.6235.85320523.12160-1.1493010.186208.27340HepG2SMNDC1
PNPLA3ENSG00000100344.6215.49580801.76560-1.8955054.1801052.69840HepG2SRFBP1
PNPLA3ENSG00000100344.6527.178901067.21260-1.0175023.4342022.35130HepG2SRSF1
PNPLA3ENSG00000100344.694.56410273.32800-1.5313010.025508.02120HepG2SRSF3
PNPLA3ENSG00000100344.6765.61120576.527800.409101.958801.42050HepG2SRSF5
PNPLA3ENSG00000100344.6381.58300868.22400-1.1861028.5320027.11940HepG2SRSF9
PNPLA3ENSG00000100344.61601.59730696.125501.2020043.5332042.08620HepG2SSB
PNPLA3ENSG00000100344.6385.68190669.07170-0.794705.257803.55410HepG2SSRP1
PNPLA3ENSG00000100344.6321.11750479.15580-0.577402.711101.52170HepG2SUB1
PNPLA3ENSG00000100344.6452.05120655.67910-0.536505.981105.12980HepG2SUCLG1
PNPLA3ENSG00000100344.6353.34460677.15720-0.938407.194605.09470HepG2SUGP2
PNPLA3ENSG00000100344.6750.16940477.958500.650204.308503.49080HepG2SUPV3L1
PNPLA3ENSG00000100344.6508.09870250.158301.0222010.269409.00280HepG2TARDBP
PNPLA3ENSG00000100344.6994.44250657.170700.597502.278301.31010HepG2TBRG4
PNPLA3ENSG00000100344.6701.09030881.42690-0.330202.496101.69950HepG2TIA1
PNPLA3ENSG00000100344.6563.57940348.197000.694607.048006.31740HepG2TIAL1
PNPLA3ENSG00000100344.6266.53110514.91760-0.950006.579304.37980HepG2TRA2A
PNPLA3ENSG00000100344.6134.79650235.77850-0.806604.061202.18050HepG2TROVE2
PNPLA3ENSG00000100344.6310.34200517.98960-0.739103.970803.22430HepG2U2AF1
PNPLA3ENSG00000100344.6403.83010603.80730-0.580303.255402.34790HepG2UBE2L3
PNPLA3ENSG00000100344.6131.33950282.32500-1.104108.354107.03590HepG2UCHL5
PNPLA3ENSG00000100344.61223.25150945.267200.371804.824203.94330HepG2UPF1
PNPLA3ENSG00000100344.6536.65820912.62170-0.7660012.5941011.45780HepG2UTP3
PNPLA3ENSG00000100344.6245.25130504.28660-1.040007.536005.51490HepG2XRCC5
PNPLA3ENSG00000100344.6302.30280563.90740-0.899506.565204.98210HepG2XRCC6
PNPLA3ENSG00000100344.6839.703101039.61600-0.308103.641003.03720HepG2ZNF622
PNPLA3ENSG00000100344.63.3230019.35890-2.542402.795102.18730K562FXR1
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for PNPLA3 is not available on ENCORE database.





11 RBPs can affect the splicing of PNPLA3 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEPNPLA3ENSG00000100344.6chr22+4433521544335333443329304433315244335872443360050.123000.000020.00363includedHepG2G3BP1
SEPNPLA3ENSG00000100344.6chr22+4433735344337481443358724433600544340570443406750.090000.000480.03451includedHepG2AKAP1
SEPNPLA3ENSG00000100344.6chr22+4433521544335333443329304433315244335872443360050.169000.000010.01397includedHepG2LIN28B
SEPNPLA3ENSG00000100344.6chr22+4433521544335333443329304433315244335872443360050.101000.001270.06182includedHepG2PTBP1
SEPNPLA3ENSG00000100344.6chr22+4433521544335333443329304433315244335872443360050.119000.000010.01235includedHepG2UPF1
SEPNPLA3ENSG00000100344.6chr22+4433521544335333443329304433315244335872443360050.113000.001300.05155includedHepG2MATR3
SEPNPLA3ENSG00000100344.6chr22+4433521544335333443329304433315244335872443360050.193000.000200.03938includedHepG2RBM15
SEPNPLA3ENSG00000100344.6chr22+4433521544335333443329304433315244335872443360050.157000.000140.01522includedHepG2TIAL1
SEPNPLA3ENSG00000100344.6chr22+4433521544335333443329304433315244335872443360050.139000.000660.02799includedHepG2HNRNPC
A5SSPNPLA3ENSG00000100344.6chr22+4432888644329123443288864432896744330485443305460.221000.000290.03776longerHepG2TAF15
A5SSPNPLA3ENSG00000100344.6chr22+4432888644329123443288864432896744330485443305460.417000.000000.00000longerHepG2HNRNPK
A5SSPNPLA3ENSG00000100344.6chr22+4432888644329123443288864432896744330485443305460.197000.000050.01101longerHepG2MATR3

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for PNPLA3 is not avaliable on ENCORE database.