TTL

General Information

Gene Name       : TTL
Gene ID             : ENSG00000114999.7
Essential Gene : No

Functions

Localization

Domains (AlphaFold: TTL)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878TTLENSG00000114999.715.5815.6215.60ENCSR000AEF
HepG2TTLENSG00000114999.728.3338.0333.18ENCSR985KAT
K562TTLENSG00000114999.730.2325.4927.86ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for TTL is not avaliable on ENCORE database.



Proteins bound to RNA
  • TTL RNA is bound by 22 proteins.  







eCLIP assay for TTL is not avaliable on ENCORE database.





22 proteins are bound to TTL RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr2113287890113287910+3'-UTR3.239893.06830K562UPF1
chr2113288214113288294+3'-UTR3.463627.29435K562UPF1
chr2113287322113287400+3'-UTR3.2760910.34079K562FAM120A
chr2113287977113288064+3'-UTR3.070684.20475K562UPF1
chr2113289608113289668+3'-UTR5.4836820.74880K562LIN28B
chr2113287434113287445+3'-UTR3.617053.88742K562FAM120A
chr2113289587113289608+3'-UTR5.1913216.96193K562LIN28B
chr2113289121113289198+3'-UTR3.013834.67518K562FAM120A
chr2113287218113287315+3'-UTR3.210976.23843K562FAM120A
chr2113289573113289606+3'-UTR6.2345218.36099HepG2LIN28B
chr2113288270113288296+3'-UTR3.524844.23488K562FAM120A
chr2113289116113289178+3'-UTR3.110806.02951HepG2FAM120A
chr2113289606113289681+3'-UTR5.0871421.06851HepG2LIN28B
chr2113239866113239927+5'-UTR,CDS3.721154.46401K562DDX3X
chr2113239784113239872+5'-UTR5.8365234.19269HepG2DDX3X
chr2113239738113239779+5'-UTR6.3902013.45742HepG2DDX3X
chr2113239872113239920+5'-UTR6.0089519.15345HepG2DDX3X
chr2113243485113243567+CDS,intron-Proximal4.319507.13970HepG2PRPF8
chr2113251900113251961+CDS,intron-Proximal3.636073.12746HepG2GRWD1
chr2113251950113251977+CDS,intron-Proximal4.286764.16174HepG2PRPF8
chr2113260505113260562+CDS4.384244.96452K562YBX3
chr2113277942113278031+CDS,intron-Proximal5.5394512.43500HepG2PRPF8
chr2113277998113278137+CDS,intron-Distal,intron-Proximal3.666319.14595K562PRPF8
chr2113240060113240135+CDS,intron-Proximal4.413425.34978HepG2PRPF8
chr2113260585113260706+CDS3.028703.25772K562ZNF622
chr2113277807113277909+CDS,intron-Proximal4.700714.69961K562SF3B4
chr2113277803113277887+CDS,intron-Proximal5.209885.32775HepG2SF3B4
chr2113240046113240079+CDS,intron-Proximal4.555147.51958HepG2DDX3X
chr2113239946113239997+CDS4.241784.82666HepG2DDX3X
chr2113260668113260717+CDS4.698864.34038HepG2BCLAF1
chr2113280583113280629+intron-Distal3.622295.56133HepG2SUGP2
chr2113280207113280301+intron-Distal,intron-Proximal4.249708.18586HepG2SUGP2
chr2113279934113279992+intron-Distal3.012193.00437HepG2HNRNPK
chr2113281021113281060+intron-Distal4.875495.72657HepG2MATR3
chr2113240487113240588+intron-Distal4.665564.48994K562RBM15
chr2113280946113281051+intron-Distal3.4347913.28311HepG2SUGP2
chr2113280951113281059+intron-Distal3.809205.72424K562MATR3
chr2113244667113244720+intron-Distal3.819933.69113K562LIN28B
chr2113252889113253000+intron-Distal5.082345.89856K562PTBP1
chr2113281069113281131+intron-Distal3.704313.60408HepG2XPO5
chr2113280055113280131+intron-Distal4.907456.05753HepG2SUGP2
chr2113240263113240335+intron-Distal4.470284.12401HepG2U2AF2
chr2113252153113252321+intron-Distal3.732623.14791K562HNRNPL
chr2113280950113281021+intron-Distal4.1006613.85109HepG2MATR3
chr2113280924113281009+intron-Distal3.717004.00200K562EIF4G2
chr2113260873113260944+intron-Distal3.832854.50744HepG2U2AF2
chr2113253452113253572+intron-Distal4.540374.64001HepG2U2AF2
chr2113281156113281213+intron-Distal4.498923.97018HepG2HNRNPM
chr2113280035113280149+intron-Distal,intron-Proximal4.208004.87826HepG2MATR3
chr2113285782113285900+intron-Distal3.764996.26907HepG2SUGP2
chr2113280231113280286+intron-Distal,intron-Proximal3.111373.47356HepG2HNRNPK
chr2113260789113260849+intron-Proximal4.635534.03304K562RBM22
chr2113278002113278069+intron-Proximal5.167366.44303K562AQR
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for TTL is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for TTL is not available on ENCORE database.

  • 124 RBPs can affect the levels of TTL.  








The Knockdown/knockout RNA-Seq assay for TTL is not available on ENCORE database.





124 RBPs can affect the gene expression of TTL :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
TTLENSG00000114999.71666.656601283.710100.376503.097801.96980HepG2AATF
TTLENSG00000114999.73190.517601527.326801.0627053.1754051.34160HepG2ACO1
TTLENSG00000114999.72434.978801580.171100.623706.001705.25290HepG2AKAP1
TTLENSG00000114999.71961.311701534.637600.353805.254604.22890HepG2AKAP8L
TTLENSG00000114999.71068.906601542.48720-0.529104.250503.15730HepG2BCLAF1
TTLENSG00000114999.71047.313002110.69630-1.0110011.2019010.10470HepG2BOP1
TTLENSG00000114999.72154.483401803.746100.256202.211501.51750HepG2CALR
TTLENSG00000114999.7472.629901242.19790-1.3941025.0045022.99660HepG2CIRBP
TTLENSG00000114999.7925.881401527.15720-0.7219016.2236014.89730HepG2CKAP4
TTLENSG00000114999.71038.238001937.79200-0.900308.480607.33300HepG2CPSF6
TTLENSG00000114999.74255.155302169.230200.9719036.6882034.89190HepG2CELF1
TTLENSG00000114999.71862.597902332.62550-0.324606.314505.26120HepG2DAZAP1
TTLENSG00000114999.7696.458401417.25380-1.025008.465507.34950HepG2DDX21
TTLENSG00000114999.72811.722001745.275900.687907.712406.49830HepG2DDX55
TTLENSG00000114999.71168.909901582.01460-0.436603.963702.76220HepG2DDX5
TTLENSG00000114999.7944.091501494.15160-0.662308.861007.20720HepG2DHX30
TTLENSG00000114999.71033.206501461.27990-0.500108.165607.12090HepG2DKC1
TTLENSG00000114999.7801.488401549.14960-0.9507023.9457022.09610HepG2DNAJC21
TTLENSG00000114999.71173.453901535.46140-0.387906.746005.79090HepG2DNAJC2
TTLENSG00000114999.7813.533801250.06400-0.619705.829104.98630HepG2EIF2S1
TTLENSG00000114999.7870.870101381.55240-0.665806.063405.12060HepG2EIF4A3
TTLENSG00000114999.72772.340101344.973501.0434012.5725011.16090HepG2EIF4B
TTLENSG00000114999.71605.604102204.36290-0.457204.848203.78850HepG2EIF4G2
TTLENSG00000114999.71932.009501492.615300.372202.143001.40890HepG2EWSR1
TTLENSG00000114999.73072.021201895.871600.696208.085606.84720HepG2FIP1L1
TTLENSG00000114999.7948.622101940.99310-1.032905.587604.14760HepG2FTO
TTLENSG00000114999.71630.295602196.79660-0.430303.129502.45350HepG2GPKOW
TTLENSG00000114999.71056.693001563.99070-0.565706.785805.84020HepG2HNRNPA1
TTLENSG00000114999.72649.140502143.667400.305304.318203.19460HepG2HNRNPA2B1
TTLENSG00000114999.71111.441801739.64770-0.646408.614807.44310HepG2HNRNPC
TTLENSG00000114999.71687.468702558.13080-0.6002014.2751012.81600HepG2HNRNPF
TTLENSG00000114999.7900.531901308.93460-0.539505.214804.27860HepG2HNRNPK
TTLENSG00000114999.71474.772102124.89500-0.5269014.2799012.86010HepG2HNRNPL
TTLENSG00000114999.71326.537902096.42920-0.660305.935205.04980HepG2HNRNPLL
TTLENSG00000114999.7915.644201728.14640-0.9164028.0231026.26140HepG2HNRNPU
TTLENSG00000114999.71682.664702519.04760-0.582109.346508.08700HepG2IGF2BP1
TTLENSG00000114999.72071.733301314.323800.656407.760706.68880HepG2IGF2BP2
TTLENSG00000114999.72461.236401233.243000.996804.914903.61980HepG2IGF2BP3
TTLENSG00000114999.71353.090501765.24480-0.383607.549306.40140HepG2ILF2
TTLENSG00000114999.71036.666401396.26920-0.429607.569205.94350HepG2KIF1C
TTLENSG00000114999.71904.441001542.571300.303902.415801.35970HepG2LARP7
TTLENSG00000114999.72486.024601402.002200.8263010.356809.19830HepG2MATR3
TTLENSG00000114999.71868.394801072.945100.800105.064403.66790HepG2METAP2
TTLENSG00000114999.71911.117201534.629200.316402.991102.15080HepG2MSI2
TTLENSG00000114999.71096.264702137.73890-0.963509.197407.40110HepG2MTPAP
TTLENSG00000114999.71817.672801435.061100.340902.314801.73330HepG2NCBP2
TTLENSG00000114999.71703.828102313.01750-0.441006.671905.49380HepG2NOL12
TTLENSG00000114999.71189.393901858.77030-0.644105.470304.43550HepG2NSUN2
TTLENSG00000114999.71695.785401236.933000.455107.514006.59220HepG2PCBP1
TTLENSG00000114999.71075.444801480.04810-0.460703.081901.30890HepG2PHF6
TTLENSG00000114999.7859.450201541.36900-0.8427019.1738017.36530HepG2PPIL4
TTLENSG00000114999.71340.987701588.68080-0.244502.595001.84430HepG2PRPF4
TTLENSG00000114999.7686.478701346.49320-0.9719012.9815011.41380HepG2PRPF8
TTLENSG00000114999.72315.009301258.578200.8791028.1696026.77840HepG2PTBP1
TTLENSG00000114999.71267.007802207.93030-0.8013014.9190013.68270HepG2PUF60
TTLENSG00000114999.73447.429802343.760000.5566019.7581018.46650HepG2PUM1
TTLENSG00000114999.72509.021601815.271000.466806.677005.41880HepG2RBM15
TTLENSG00000114999.73801.665302400.029100.6635017.7687016.68730HepG2RBM22
TTLENSG00000114999.7771.354701510.47970-0.9695013.1020010.87070HepG2RCC2
TTLENSG00000114999.72476.572001400.716100.8221024.4569023.16710HepG2NELFE
TTLENSG00000114999.71805.180601304.505200.468507.932406.96780HepG2RECQL
TTLENSG00000114999.72302.731802755.44840-0.258901.930801.34770HepG2RPLP0
TTLENSG00000114999.71098.966601534.84030-0.481902.703101.76990HepG2RPS10
TTLENSG00000114999.71478.14700997.635700.567107.148106.21330HepG2RPS19
TTLENSG00000114999.71085.098401523.90450-0.489903.171202.31590HepG2RPS3A
TTLENSG00000114999.72343.660101751.154200.420403.799502.52960HepG2RPS5
TTLENSG00000114999.71118.785901538.99250-0.460108.376307.34600HepG2SAFB2
TTLENSG00000114999.71472.640601001.196400.556605.687304.35230HepG2SERBP1
TTLENSG00000114999.72045.959901588.183500.365301.947001.37900HepG2SF3A3
TTLENSG00000114999.72112.535801310.427300.6888017.0481015.76970HepG2SF3B4
TTLENSG00000114999.71345.556302116.94700-0.6538019.7914018.24540HepG2SLBP
TTLENSG00000114999.72545.341901794.728100.5040014.6256013.32920HepG2SMN1
TTLENSG00000114999.71104.830401520.42330-0.460602.932901.30520HepG2SND1
TTLENSG00000114999.74099.853902710.763000.5968020.6122019.57550HepG2SRFBP1
TTLENSG00000114999.72354.184601367.767700.7833023.8120022.72140HepG2SRSF1
TTLENSG00000114999.72579.498202179.943000.242702.912402.27080HepG2SRSF5
TTLENSG00000114999.71710.332302513.21310-0.5553012.5275011.23110HepG2SRSF7
TTLENSG00000114999.72035.618901112.722000.8713025.2988023.94360HepG2SRSF9
TTLENSG00000114999.71264.230202353.61620-0.8966031.5194030.21950HepG2SSB
TTLENSG00000114999.72025.109501325.390700.611505.067503.52990HepG2STIP1
TTLENSG00000114999.72807.788802479.252700.179402.042301.49210HepG2SUCLG1
TTLENSG00000114999.7933.350501280.38460-0.456104.587803.39350HepG2SUPT6H
TTLENSG00000114999.72973.595301229.306701.2743051.4639049.43970HepG2TAF15
TTLENSG00000114999.71477.939702042.94930-0.467103.778202.94650HepG2TARDBP
TTLENSG00000114999.7922.610001679.22780-0.8640018.0975017.02500HepG2TIAL1
TTLENSG00000114999.71475.434001694.22740-0.199502.048801.54950HepG2TRIM56
TTLENSG00000114999.71065.399301621.92860-0.606306.593105.63690HepG2U2AF1
TTLENSG00000114999.72919.357302283.052600.354602.501501.70790HepG2UBE2L3
TTLENSG00000114999.71303.038601026.389700.344202.451101.73610HepG2UCHL5
TTLENSG00000114999.71217.495401447.74230-0.249902.442201.44730HepG2UTP18
TTLENSG00000114999.72320.672401359.830500.7710023.8025022.30530HepG2UTP3
TTLENSG00000114999.72570.891901536.479200.742506.295404.39920HepG2XRCC5
TTLENSG00000114999.72298.662401718.367500.419702.419601.42970HepG2XRCC6
TTLENSG00000114999.7991.532901710.31770-0.786509.592608.26070HepG2XRN2
TTLENSG00000114999.72107.461701567.827600.426609.025707.93100HepG2ZC3H8
TTLENSG00000114999.72506.935001549.055200.6944025.7178024.47540HepG2ZNF622
TTLENSG00000114999.71113.586201915.45790-0.782509.255608.29480K562AGGF1
TTLENSG00000114999.71685.829702104.55900-0.320102.911501.89620K562AKAP8
TTLENSG00000114999.71364.399701993.06180-0.546705.818704.84990K562AKAP8L
TTLENSG00000114999.71724.900902431.46160-0.495305.788504.99370K562AQR
TTLENSG00000114999.71584.232702091.09020-0.400503.721402.64880K562ATP5C1
TTLENSG00000114999.7778.648501466.98860-0.9138013.2803011.31060K562BOP1
TTLENSG00000114999.71106.247301704.14820-0.623407.939905.89480K562CIRBP
TTLENSG00000114999.71975.626802364.17150-0.259002.825501.70680K562CPEB4
TTLENSG00000114999.71301.602101559.87000-0.261102.149301.44920K562CPSF6
TTLENSG00000114999.7893.665701091.67320-0.288702.320701.36950K562CSTF2
TTLENSG00000114999.71524.830201825.75110-0.259802.825201.60170K562DDX21
TTLENSG00000114999.71038.909001261.49270-0.280103.042301.64810K562DDX27
TTLENSG00000114999.7668.24280901.15960-0.431403.373701.88130K562DNAJC21
TTLENSG00000114999.7845.510601273.47150-0.590905.943104.56820K562EFTUD2
TTLENSG00000114999.71435.530101918.78070-0.418606.216505.20220K562EIF2S2
TTLENSG00000114999.71205.15760852.416400.499502.482201.53220K562EIF3A
TTLENSG00000114999.7857.255801363.53960-0.669605.933304.33390K562EIF3D
TTLENSG00000114999.71462.098301979.97980-0.437404.490103.39040K562FIP1L1
TTLENSG00000114999.7978.320601345.13670-0.459403.731202.65600K562FTO
TTLENSG00000114999.71548.367101185.819300.384804.816904.04830K562FXR1
TTLENSG00000114999.71209.325801520.15890-0.330002.867801.40550K562G3BP1
TTLENSG00000114999.71006.360001489.32420-0.565506.637905.41300K562GPKOW
TTLENSG00000114999.71845.619002557.06110-0.470405.919504.81060K562GRSF1
TTLENSG00000114999.71037.151601588.11930-0.614705.878504.00560K562HNRNPK
TTLENSG00000114999.71142.357401943.07220-0.7663017.2059015.09890K562HNRNPU
TTLENSG00000114999.71298.141901617.16230-0.317002.545101.41550K562IGF2BP3
TTLENSG00000114999.71559.329502115.34340-0.440003.797302.80920K562KIF1C
TTLENSG00000114999.7840.260001271.61280-0.597804.370003.17050K562KRR1
TTLENSG00000114999.71506.996302024.73650-0.426102.413901.43230K562MAK16
TTLENSG00000114999.71068.774001453.73300-0.443803.514902.52180K562METAP2
TTLENSG00000114999.71449.189301796.06120-0.309604.162803.18830K562MTPAP
TTLENSG00000114999.71257.800801660.96290-0.401102.527301.69270K562NAA15
TTLENSG00000114999.71691.117601995.61710-0.238903.688702.84080K562NSUN2
TTLENSG00000114999.7728.804801435.18700-0.977605.958604.33980K562PABPN1
TTLENSG00000114999.71124.031701486.87280-0.403603.716002.58360K562PCBP2
TTLENSG00000114999.71681.813702247.61450-0.418404.106703.08120K562PPIG
TTLENSG00000114999.7748.831301239.23340-0.726708.347807.04330K562PRPF8
TTLENSG00000114999.72953.950403462.29620-0.229102.331001.44830K562PUM2
TTLENSG00000114999.71112.538401976.99230-0.829509.539908.58040K562PUS1
TTLENSG00000114999.7789.635701148.46630-0.540402.879901.42990K562RAVER1
TTLENSG00000114999.71497.793401925.93160-0.362702.564301.99010K562RBM15
TTLENSG00000114999.7715.144001142.19750-0.675508.770206.23470K562RBM25
TTLENSG00000114999.7658.652001084.11480-0.718908.321906.59690K562RCC2
TTLENSG00000114999.7905.315701252.07240-0.467805.389504.16800K562SF3B4
TTLENSG00000114999.71125.463701503.06430-0.417403.630002.39460K562SRSF5
TTLENSG00000114999.71368.781701629.30990-0.251402.554701.43290K562SRSF7
TTLENSG00000114999.71235.309701610.82950-0.382903.142002.38770K562TARDBP
TTLENSG00000114999.71231.249701553.81350-0.335703.072302.20190K562TIA1
TTLENSG00000114999.7851.731701143.18560-0.424603.006602.02800K562TIAL1
TTLENSG00000114999.71187.292101524.63180-0.360803.000601.85480K562TRA2A
TTLENSG00000114999.7812.476001167.29580-0.522804.046602.67160K562U2AF1
TTLENSG00000114999.7884.328901205.34680-0.446804.870903.80740K562U2AF2
TTLENSG00000114999.71201.327302004.03750-0.738304.228302.51380K562UTP18
TTLENSG00000114999.71697.215302880.47990-0.7631014.7957012.23080K562WRN
TTLENSG00000114999.72101.662902739.29650-0.382304.038502.96250K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for TTL is not available on ENCORE database.





15 RBPs can affect the splicing of TTL :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SETTLENSG00000114999.7chr2+113278798113278918113277858113278002113286257113299316-0.087000.004220.06625excludedK562SRSF1
SETTLENSG00000114999.7chr2+1132534731132536051132517191132519521132587821132589180.064000.000830.08343includedK562FMR1
SETTLENSG00000114999.7chr2+113278798113278918113277858113278002113286257113299316-0.081000.000460.09291excludedK562WDR43
SETTLENSG00000114999.7chr2+113277858113278002113260488113260758113286257113299316-0.066000.005710.05887excludedHepG2U2AF2
SETTLENSG00000114999.7chr2+1132534731132536051132517191132519521132587821132589180.076000.001920.02120includedK562AQR
SETTLENSG00000114999.7chr2+113277858113278002113260488113260758113286257113299316-0.146000.000120.00202excludedK562AQR
SETTLENSG00000114999.7chr2+113278798113278918113277858113278002113286257113299316-0.062000.000850.07129excludedHepG2SRSF7
SETTLENSG00000114999.7chr2+113253473113253605113251719113251952113258782113258918-0.054000.000290.03316excludedHepG2SRSF7
SETTLENSG00000114999.7chr2+1132787981132789181132778581132780021132862571132993160.122000.002410.08104includedHepG2MATR3
SETTLENSG00000114999.7chr2+113277858113278002113260488113260758113286257113299316-0.230000.000020.00547excludedK562HNRNPM
SETTLENSG00000114999.7chr2+1132534731132536051132517191132519521132587821132589180.053000.001450.08307includedK562HNRNPL
SETTLENSG00000114999.7chr2+113253473113253605113251719113251952113258782113258918-0.065000.001180.02921excludedHepG2SRSF1
SETTLENSG00000114999.7chr2+1132434931132435721132397301132400781132517191132519520.152000.000140.03225includedK562EIF4G2
SETTLENSG00000114999.7chr2+1132534731132536051132517191132519521132587821132589180.108000.000130.00768includedK562TARDBP
SETTLENSG00000114999.7chr2+1132787981132789181132778581132780021132862571132993160.158000.000010.01836includedHepG2GTF2F1
SETTLENSG00000114999.7chr2+1132787981132789181132778581132780021132862571132993160.189000.000010.00357includedHepG2EIF3D
SETTLENSG00000114999.7chr2+113243493113243572113239730113240078113251719113251952-0.219000.000460.02111excludedHepG2HNRNPC
SETTLENSG00000114999.7chr2+1132787981132789181132778581132780021132862571132899880.101000.001210.06965includedHepG2SRSF9
SETTLENSG00000114999.7chr2+1132534731132536051132517191132519521132587821132589180.099000.002050.03457includedK562HNRNPC
SETTLENSG00000114999.7chr2+113277858113278002113260488113260758113286257113299316-0.189000.000000.00018excludedK562HNRNPC

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for TTL is not avaliable on ENCORE database.