PHLPP1

General Information

Gene Name       : PHLPP1
Gene ID             : ENSG00000081913.13
Essential Gene : No

Functions

Localization

Domains (AlphaFold: PHLPP1)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878PHLPP1ENSG00000081913.133.913.173.54ENCSR000AEF
HepG2PHLPP1ENSG00000081913.1310.4711.9611.21ENCSR985KAT
K562PHLPP1ENSG00000081913.133.494.814.15ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for PHLPP1 is not avaliable on ENCORE database.



Proteins bound to RNA
  • PHLPP1 RNA is bound by 25 proteins.  







eCLIP assay for PHLPP1 is not avaliable on ENCORE database.





25 proteins are bound to PHLPP1 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr186064721860647314+3'-UTR5.3553111.17322K562PUM2
chr186064746760647544+3'-UTR4.036105.96194HepG2PCBP2
chr186064728960647386+3'-UTR5.8170411.66751HepG2PCBP2
chr186038364660383728+5'-UTR,CDS3.813613.15756HepG2EIF3H
chr186038312260383214+5'-UTR,CDS3.301026.23402HepG2FXR2
chr186038312760383200+5'-UTR,CDS4.125985.87392HepG2ZNF800
chr186038441860384531+5'-UTR,CDS,intron-Proximal3.507159.76884HepG2BUD13
chr186038296760383087+5'-UTR,CDS3.751085.52508HepG2FTO
chr186038314260383214+5'-UTR,CDS4.265188.93791HepG2SDAD1
chr186064646060646519+CDS4.767635.65349K562RBM15
chr186064635560646403+CDS4.032893.48187K562RBM15
chr186050604860506145+CDS,intron-Proximal3.130117.97025HepG2BCLAF1
chr186058719760587345+CDS3.793263.68794HepG2YBX3
chr186061248060612545+CDS,intron-Proximal4.972745.68502HepG2PRPF8
chr186063983360639884+CDS3.526883.87469HepG2BCLAF1
chr186058719460587267+CDS3.249847.20615HepG2BCLAF1
chr186058219860582245+CDS,intron-Proximal3.026884.61799HepG2BCLAF1
chr186057248760572557+CDS,intron-Proximal5.681135.35117HepG2PRPF8
chr186038448060384556+CDS,intron-Proximal3.360454.18161HepG2RBM15
chr186056315560563247+CDS,intron-Proximal3.5268810.11361HepG2BCLAF1
chr186058728460587345+CDS3.345603.94979HepG2BCLAF1
chr186038866760388741+intron-Distal3.097133.44195K562TARDBP
chr186043920860439293+intron-Distal3.445843.04190HepG2MATR3
chr186058874260588867+intron-Distal4.5548410.47376HepG2QKI
chr186043217260432297+intron-Distal4.140753.10961HepG2MATR3
chr186043257760432623+intron-Distal3.111274.61989HepG2SUGP2
chr186041107660411124+intron-Distal3.919643.27946HepG2HNRNPM
chr186041468760414825+intron-Distal4.033843.57543K562ILF3
chr186050205160502108+intron-Distal4.221424.25479HepG2PCBP2
chr186053455060534628+intron-Distal3.433163.51804HepG2HNRNPL
chr186042153260421608+intron-Distal4.866756.95924HepG2HNRNPM
chr186041665560416793+intron-Distal3.226956.64539HepG2QKI
chr186050210860502142+intron-Distal4.963903.78681HepG2PCBP2
chr186043083860430902+intron-Distal4.265743.27829HepG2MATR3
chr186045301560453074+intron-Distal3.990773.84389HepG2SUGP2
chr186038514360385226+intron-Distal3.677216.96989HepG2U2AF2
chr186041684760416902+intron-Distal5.315506.88699HepG2XPO5
chr186040053260400763+intron-Distal3.050764.81794K562KHSRP
chr186041098060411037+intron-Distal5.291936.97910HepG2PCBP2
chr186040590760405990+intron-Distal5.161486.58335HepG2QKI
chr186043922660439336+intron-Distal3.466073.30286HepG2PTBP1
chr186050081860500909+intron-Distal3.896563.45805K562KHSRP
chr186041469060414803+intron-Distal3.255177.79729HepG2PTBP1
chr186042681960426945+intron-Distal4.3218414.44400HepG2QKI
chr186043087260430916+intron-Distal3.329813.59523HepG2SUGP2
chr186056524660565293+intron-Distal3.404403.83822HepG2PTBP1
chr186043352060433622+intron-Distal3.871713.98726HepG2RBFOX2
chr186041665560416741+intron-Distal4.1691216.04546HepG2PTBP1
chr186043269760432746+intron-Distal3.906003.35377HepG2QKI
chr186053458960534686+intron-Distal3.114804.78667HepG2QKI
chr186043094160431008+intron-Distal4.639245.01910HepG2MATR3
chr186046828660468349+intron-Distal6.041547.79030HepG2PCBP2
chr186042144260421495+intron-Distal3.830574.63118HepG2HNRNPM
chr186041469360414793+intron-Distal6.3266754.41749HepG2PCBP2
chr186043193560432007+intron-Distal3.026846.39939HepG2SUGP2
chr186040055760400630+intron-Distal3.873563.47043HepG2KHSRP
chr186043250760432577+intron-Distal3.821565.30446HepG2SUGP2
chr186043064760430730+intron-Distal3.656314.81844HepG2SUGP2
chr186053348960533543+intron-Distal3.103233.21744HepG2HNRNPC
chr186043092760431029+intron-Distal4.461513.09122HepG2PTBP1
chr186040848160408545+intron-Distal3.389893.42785HepG2HNRNPM
chr186041620260416290+intron-Distal3.010974.14321HepG2HNRNPL
chr186043190460432007+intron-Distal5.133218.46785HepG2MATR3
chr186041123260411300+intron-Distal5.058415.16513HepG2HNRNPM
chr186044709660447180+intron-Distal5.323329.67630HepG2HNRNPM
chr186044385360443868+intron-Distal3.924514.93809HepG2HNRNPC
chr186047060460470700+intron-Distal4.601835.89032HepG2QKI
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for PHLPP1 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for PHLPP1 is not available on ENCORE database.

  • 78 RBPs can affect the levels of PHLPP1.  








The Knockdown/knockout RNA-Seq assay for PHLPP1 is not available on ENCORE database.





78 RBPs can affect the gene expression of PHLPP1 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
PHLPP1ENSG00000081913.9459.423001022.30290-1.1539031.8167030.29380HepG2ACO1
PHLPP1ENSG00000081913.9563.657901649.49600-1.5491027.3558025.89250HepG2AKAP1
PHLPP1ENSG00000081913.9562.882701205.41880-1.0986015.1094012.90390HepG2AKAP8
PHLPP1ENSG00000081913.91038.916701364.78220-0.393602.850502.05510HepG2ASCC1
PHLPP1ENSG00000081913.91309.067601528.79430-0.223902.200501.57550HepG2AUH
PHLPP1ENSG00000081913.9406.81750896.82080-1.1404017.4212016.10620HepG2BOP1
PHLPP1ENSG00000081913.9655.56070856.92290-0.386403.075102.26480HepG2CALR
PHLPP1ENSG00000081913.9890.151901296.64910-0.542704.957903.93830HepG2CIRBP
PHLPP1ENSG00000081913.9559.41940969.55880-0.7934013.7634012.54390HepG2CELF1
PHLPP1ENSG00000081913.9947.52050765.738800.307202.134401.34260HepG2DDX24
PHLPP1ENSG00000081913.9946.142601580.01250-0.739808.420507.37900HepG2DDX3X
PHLPP1ENSG00000081913.9444.55170644.09660-0.534903.225202.39960HepG2DDX55
PHLPP1ENSG00000081913.9460.823201357.45140-1.5586026.6825025.06180HepG2DDX6
PHLPP1ENSG00000081913.91008.027701363.77530-0.436103.293701.38210HepG2EIF3H
PHLPP1ENSG00000081913.9804.529001403.99400-0.803306.893705.83880HepG2EIF4B
PHLPP1ENSG00000081913.91417.50780985.251400.524705.186904.09170HepG2EIF4G2
PHLPP1ENSG00000081913.91017.529001755.28470-0.7866020.1824018.81180HepG2ETF1
PHLPP1ENSG00000081913.9760.40990998.97580-0.393703.385102.46070HepG2EWSR1
PHLPP1ENSG00000081913.9780.401301151.70950-0.561504.315503.37130HepG2FIP1L1
PHLPP1ENSG00000081913.9941.577401455.01690-0.627906.393205.36440HepG2FXR1
PHLPP1ENSG00000081913.9824.985401349.59790-0.710107.268706.21520HepG2G3BP1
PHLPP1ENSG00000081913.91290.22320933.264500.467203.423302.71710HepG2GPKOW
PHLPP1ENSG00000081913.9592.77820868.28460-0.550703.004101.35990HepG2GTF2F1
PHLPP1ENSG00000081913.9751.73340976.00880-0.376704.354603.14710HepG2HDGF
PHLPP1ENSG00000081913.9963.26790695.016500.470804.004703.24800HepG2HNRNPA1
PHLPP1ENSG00000081913.9760.82540958.11680-0.332603.228802.23050HepG2HNRNPA2B1
PHLPP1ENSG00000081913.91063.79730696.129000.611709.193207.98460HepG2HNRNPF
PHLPP1ENSG00000081913.9704.761101366.92560-0.9557014.5014013.02710HepG2HNRNPK
PHLPP1ENSG00000081913.9744.81090949.69700-0.350604.112303.30290HepG2HNRNPL
PHLPP1ENSG00000081913.91213.81430685.479500.8243013.1578011.69970HepG2IGF2BP1
PHLPP1ENSG00000081913.9922.186801371.78560-0.572905.346404.43510HepG2IGF2BP2
PHLPP1ENSG00000081913.9649.06480784.47430-0.273402.015701.37850HepG2ILF2
PHLPP1ENSG00000081913.9359.20520652.26150-0.860607.195505.18900HepG2KHDRBS1
PHLPP1ENSG00000081913.9529.99540683.53400-0.367002.348201.30870HepG2LARP7
PHLPP1ENSG00000081913.9745.349601463.62810-0.9736012.1660010.90820HepG2MATR3
PHLPP1ENSG00000081913.9335.03530629.86400-0.910705.781604.30600HepG2METAP2
PHLPP1ENSG00000081913.9856.902901498.06860-0.805909.427508.30000HepG2NCBP2
PHLPP1ENSG00000081913.9715.744801033.79060-0.530406.552805.38400HepG2NOL12
PHLPP1ENSG00000081913.91101.21610789.740600.479503.900403.01620HepG2NSUN2
PHLPP1ENSG00000081913.9518.89520760.14520-0.550803.329502.40820HepG2PARN
PHLPP1ENSG00000081913.91140.474901358.77190-0.252702.443701.86530HepG2PCBP1
PHLPP1ENSG00000081913.91360.724301148.731400.244202.280401.57020HepG2PRPF4
PHLPP1ENSG00000081913.9628.47850916.77660-0.544703.006201.74370HepG2PRPF6
PHLPP1ENSG00000081913.91151.908001382.65490-0.263402.689802.14920HepG2PTBP1
PHLPP1ENSG00000081913.9776.206001046.79680-0.431504.342003.51160HepG2PUM2
PHLPP1ENSG00000081913.91936.861801041.282300.8953029.0169027.41400HepG2PUS1
PHLPP1ENSG00000081913.9582.10700841.54280-0.531802.383001.72530HepG2RAVER1
PHLPP1ENSG00000081913.9426.856201467.08810-1.7811064.5890062.74110HepG2RBM22
PHLPP1ENSG00000081913.91104.445101358.97100-0.299202.315001.69300HepG2RBM25
PHLPP1ENSG00000081913.9892.264101538.71760-0.7862016.6844015.57110HepG2NELFE
PHLPP1ENSG00000081913.9934.516301433.18730-0.6169011.4463010.32170HepG2RECQL
PHLPP1ENSG00000081913.9387.61210585.75810-0.595703.400202.72680HepG2RPS19
PHLPP1ENSG00000081913.9535.55040760.15800-0.505303.765402.83650HepG2RPS2
PHLPP1ENSG00000081913.9668.74900881.53390-0.398602.900802.17800HepG2SF3B1
PHLPP1ENSG00000081913.9918.841901439.42590-0.6476012.4793011.36530HepG2SF3B4
PHLPP1ENSG00000081913.91421.42080946.193100.5870012.5954011.28520HepG2SLBP
PHLPP1ENSG00000081913.9564.96880797.53110-0.497405.835104.95480HepG2SMN1
PHLPP1ENSG00000081913.9543.62920980.86750-0.851403.671902.76740HepG2SNRNP70
PHLPP1ENSG00000081913.9672.08050974.33870-0.535807.419206.46160HepG2SRSF5
PHLPP1ENSG00000081913.9992.54560683.954500.537106.945405.92290HepG2SRSF7
PHLPP1ENSG00000081913.9705.015601222.38820-0.7940017.8659016.68620HepG2SRSF9
PHLPP1ENSG00000081913.91766.859201438.664100.296403.965903.37580HepG2SSB
PHLPP1ENSG00000081913.9464.11810641.17830-0.466202.605001.94630HepG2SUPV3L1
PHLPP1ENSG00000081913.9857.805701350.60420-0.6549010.869809.87470HepG2TAF15
PHLPP1ENSG00000081913.9300.14050429.75330-0.517902.911301.89140HepG2TFIP11
PHLPP1ENSG00000081913.9854.174701240.90550-0.538806.477405.20370HepG2TIA1
PHLPP1ENSG00000081913.9572.71650752.92650-0.394702.815002.24760HepG2TRIM56
PHLPP1ENSG00000081913.91382.39960985.157500.488604.323503.54750HepG2U2AF1
PHLPP1ENSG00000081913.9145.94010378.75690-1.3759013.9625012.28460HepG2UCHL5
PHLPP1ENSG00000081913.9710.550601176.48210-0.7275015.3521013.96280HepG2UPF1
PHLPP1ENSG00000081913.9918.627601209.25780-0.396604.819203.47880HepG2UTP18
PHLPP1ENSG00000081913.9866.082601135.84700-0.391204.770204.01870HepG2UTP3
PHLPP1ENSG00000081913.9565.40510925.52720-0.711005.109403.69760HepG2XRCC6
PHLPP1ENSG00000081913.91024.875801293.90480-0.336304.832804.16130HepG2ZNF622
PHLPP1ENSG00000081913.9630.47730801.65830-0.346502.672201.71380K562CELF1
PHLPP1ENSG00000081913.9279.25640380.47130-0.446202.814601.66530K562GLRX3
PHLPP1ENSG00000081913.9353.21480463.28170-0.391302.233101.55040K562GRSF1
PHLPP1ENSG00000081913.9180.39790272.10140-0.593002.988601.79820K562HNRNPF
PHLPP1ENSG00000081913.9488.36640694.86510-0.508804.016102.65590K562MSI2
PHLPP1ENSG00000081913.9477.02610604.58340-0.341901.828801.36870K562PUS1
PHLPP1ENSG00000081913.9455.03610589.13100-0.372602.399701.84070K562RBM15
PHLPP1ENSG00000081913.9164.88570248.46620-0.591602.776501.75560K562UCHL5
PHLPP1ENSG00000081913.9638.05170471.288900.437003.154102.39000K562UPF1
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for PHLPP1 is not available on ENCORE database.





3 RBPs can affect the splicing of PHLPP1 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEPHLPP1ENSG00000081913.9chr18+605060166050614260497267604974646052766760527746-0.222000.000000.00000excludedHepG2U2AF1
SEPHLPP1ENSG00000081913.9chr18+6062425860624299606123416061250460625861606259920.088000.002200.05068includedHepG2HNRNPK
SEPHLPP1ENSG00000081913.9chr18+605060166050614260497267604974646052766760527746-0.213000.000000.00000excludedHepG2U2AF2

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for PHLPP1 is not avaliable on ENCORE database.