MMACHC

General Information

Gene Name       : MMACHC
Gene ID             : ENSG00000132763.14
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: MMACHC)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878MMACHCENSG00000132763.145.127.976.54ENCSR000AEF
HepG2MMACHCENSG00000132763.146.196.796.49ENCSR985KAT
K562MMACHCENSG00000132763.1414.7714.1114.44ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for MMACHC is not avaliable on ENCORE database.



Proteins bound to RNA
  • MMACHC RNA is bound by 3 proteins.  







eCLIP assay for MMACHC is not avaliable on ENCORE database.





3 proteins are bound to MMACHC RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr14597509945975184+3'-UTR,intron-Proximal5.9299914.10191HepG2UPF1
chr14597529845975386+3'-UTR,intron-Distal5.9012930.69359K562AKAP1
chr14597566545975741+3'-UTR5.054829.13781K562AKAP1
chr14597546545975565+3'-UTR,intron-Distal,intron-Proximal4.4950511.04592HepG2UPF1
chr14597564345975715+3'-UTR,intron-Proximal5.191537.45692HepG2UPF1
chr14597534245975418+3'-UTR,intron-Distal4.636673.87930K562UPF1
chr14597530745975375+3'-UTR,intron-Distal4.002555.39448HepG2AKAP1
chr14597567245975721+3'-UTR4.364094.22051K562UPF1
chr14596913445969246+intron-Distal3.112183.40404HepG2ILF3
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for MMACHC is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for MMACHC is not available on ENCORE database.

  • 87 RBPs can affect the levels of MMACHC.  








The Knockdown/knockout RNA-Seq assay for MMACHC is not available on ENCORE database.





87 RBPs can affect the gene expression of MMACHC :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
MMACHCENSG00000132763.10197.07310282.54180-0.519703.178702.53330HepG2ACO1
MMACHCENSG00000132763.10142.95160241.72790-0.757903.771002.56200HepG2AKAP8
MMACHCENSG00000132763.10189.14910476.53750-1.3331019.6405018.11550HepG2AUH
MMACHCENSG00000132763.10220.91970404.18710-0.871506.931006.03170HepG2BOP1
MMACHCENSG00000132763.10247.09820326.56860-0.402301.966901.30800HepG2CALR
MMACHCENSG00000132763.10317.66440458.73880-0.530202.581501.64370HepG2CCAR1
MMACHCENSG00000132763.10221.73610424.55150-0.937102.631801.90530HepG2DAZAP1
MMACHCENSG00000132763.10390.73010261.300600.580405.339604.23180HepG2DDX19B
MMACHCENSG00000132763.10189.50150331.10310-0.805104.809704.00280HepG2DDX3X
MMACHCENSG00000132763.10177.34060421.37520-1.248607.767006.17250HepG2DDX59
MMACHCENSG00000132763.10128.55380284.40830-1.145607.166206.21210HepG2DDX6
MMACHCENSG00000132763.10189.77480257.13040-0.438202.072501.45490HepG2DNAJC21
MMACHCENSG00000132763.10369.19070253.550200.542002.647201.74310HepG2EEF2
MMACHCENSG00000132763.10147.24380236.58220-0.684102.956501.80560HepG2AGO1
MMACHCENSG00000132763.10141.06230273.42460-0.954805.579904.75450HepG2EIF2S1
MMACHCENSG00000132763.10415.72380294.194100.498802.075601.47560HepG2EIF4B
MMACHCENSG00000132763.10312.36180547.14210-0.808709.716208.69970HepG2ETF1
MMACHCENSG00000132763.10203.57890276.07440-0.439502.066901.34690HepG2EWSR1
MMACHCENSG00000132763.10169.23860434.33340-1.3597011.4322010.01980HepG2FIP1L1
MMACHCENSG00000132763.10199.28590269.73320-0.436702.406901.48850HepG2HDGF
MMACHCENSG00000132763.10203.82510288.75450-0.502502.223801.59590HepG2HNRNPC
MMACHCENSG00000132763.1071.04280135.51900-0.931703.275001.82060HepG2ILF3
MMACHCENSG00000132763.10422.65640306.674500.462702.141901.58270HepG2MATR3
MMACHCENSG00000132763.10240.29730351.54660-0.548903.047502.19860HepG2MSI2
MMACHCENSG00000132763.1051.52530127.05530-1.302104.838003.63740HepG2PABPC1
MMACHCENSG00000132763.10201.13640297.46910-0.564602.308901.35850HepG2PCBP2
MMACHCENSG00000132763.1064.63250124.66110-0.947703.219001.58040HepG2PNPT1
MMACHCENSG00000132763.10152.75820425.54820-1.4781022.5962020.76660HepG2PRPF4
MMACHCENSG00000132763.10108.00690182.49250-0.756702.962802.12900HepG2PRPF8
MMACHCENSG00000132763.10214.96030286.95270-0.416702.052001.56830HepG2PTBP1
MMACHCENSG00000132763.10204.82580401.94090-0.972602.785502.18710HepG2PUF60
MMACHCENSG00000132763.10256.13710426.39410-0.735301.861401.30570HepG2PUM2
MMACHCENSG00000132763.10205.50290287.78390-0.485802.885502.25950HepG2PUS1
MMACHCENSG00000132763.10172.24990310.73600-0.851206.037305.16430HepG2QKI
MMACHCENSG00000132763.10117.18780286.96370-1.292006.682305.61300HepG2RAVER1
MMACHCENSG00000132763.10299.11930424.65000-0.505603.434602.48830HepG2RBM15
MMACHCENSG00000132763.10250.38720457.30680-0.869008.785407.98250HepG2RBM22
MMACHCENSG00000132763.10145.26820282.02830-0.957106.642605.63740HepG2RBM25
MMACHCENSG00000132763.10176.31700282.07010-0.677902.875601.91450HepG2RPS10
MMACHCENSG00000132763.10384.55360255.445700.590104.859304.04580HepG2SAFB2
MMACHCENSG00000132763.10207.04010366.62860-0.824404.982204.05940HepG2SF3A3
MMACHCENSG00000132763.10233.71760397.34090-0.765605.340104.38270HepG2SF3B1
MMACHCENSG00000132763.10184.06390293.13590-0.671402.952901.96170HepG2SMNDC1
MMACHCENSG00000132763.10199.76810442.10940-1.146107.518606.22230HepG2SNRNP70
MMACHCENSG00000132763.10159.57650516.50630-1.6945031.4591030.24930HepG2SRFBP1
MMACHCENSG00000132763.10290.95740427.52440-0.555202.646001.66970HepG2SRSF3
MMACHCENSG00000132763.10203.39310396.94630-0.964702.463301.86810HepG2SRSF5
MMACHCENSG00000132763.10149.78180253.68900-0.760205.058504.35330HepG2SRSF9
MMACHCENSG00000132763.10269.96290448.44120-0.732207.546106.78050HepG2SSB
MMACHCENSG00000132763.1070.56440121.42850-0.783102.691001.60710HepG2STIP1
MMACHCENSG00000132763.10112.53720235.51850-1.065405.516104.61240HepG2SUPV3L1
MMACHCENSG00000132763.1062.57820157.85640-1.334906.628805.20150HepG2TFIP11
MMACHCENSG00000132763.10184.90950278.70750-0.591903.408102.86430HepG2TIAL1
MMACHCENSG00000132763.10151.25890281.21630-0.894707.373706.52890HepG2TRIM56
MMACHCENSG00000132763.10128.19210371.55860-1.5353014.9470013.44260HepG2U2AF1
MMACHCENSG00000132763.1081.56020139.12420-0.770402.884002.11050HepG2UCHL5
MMACHCENSG00000132763.10173.49030325.14260-0.906208.428207.31910HepG2UPF1
MMACHCENSG00000132763.10129.84870215.64800-0.731802.663801.67860HepG2UPF2
MMACHCENSG00000132763.10236.44570313.91380-0.408902.052201.52070HepG2UTP3
MMACHCENSG00000132763.10332.94100419.96290-0.335002.090601.49430HepG2ZC3H8
MMACHCENSG00000132763.10182.29060357.59590-0.9721010.882109.97470HepG2ZNF622
MMACHCENSG00000132763.1098.52280220.49880-1.162206.054905.26700K562AGGF1
MMACHCENSG00000132763.10138.34780242.25110-0.808204.077402.83360K562AKAP8
MMACHCENSG00000132763.10141.28020229.42820-0.699503.354102.63400K562AKAP8L
MMACHCENSG00000132763.10311.64540423.18470-0.441402.535901.96860K562AQR
MMACHCENSG00000132763.10339.44270429.34870-0.339002.066101.42870K562EIF2S2
MMACHCENSG00000132763.10167.12220289.52150-0.792804.201102.89210K562EIF3D
MMACHCENSG00000132763.10297.40920123.792901.2644011.054009.38970K562EIF4A3
MMACHCENSG00000132763.10302.29540478.07450-0.661305.110703.93490K562FIP1L1
MMACHCENSG00000132763.10356.53210128.738001.4695017.3784015.97480K562FXR1
MMACHCENSG00000132763.1098.09170240.68890-1.295005.538203.58370K562HNRNPA2B1
MMACHCENSG00000132763.10740.56220494.633500.582203.470502.26960K562HNRNPL
MMACHCENSG00000132763.10115.75820243.51840-1.072904.586403.48080K562KIF1C
MMACHCENSG00000132763.10258.22450169.972700.603203.216602.30480K562MAGOH
MMACHCENSG00000132763.10134.48160233.07650-0.793403.873302.53120K562MAK16
MMACHCENSG00000132763.10342.40590169.625801.013309.403007.60050K562MATR3
MMACHCENSG00000132763.10296.31040395.07540-0.415002.612301.82580K562MTPAP
MMACHCENSG00000132763.10331.43250438.97960-0.405403.001202.22810K562NSUN2
MMACHCENSG00000132763.1086.20950210.57420-1.288404.907303.48340K562PABPN1
MMACHCENSG00000132763.1046.53230227.60690-2.2902011.9980010.91370K562PUS1
MMACHCENSG00000132763.10107.85800221.70480-1.039505.462104.65370K562RBM15
MMACHCENSG00000132763.10118.71040259.06850-1.125904.179202.18580K562RBM39
MMACHCENSG00000132763.10272.86600166.631500.711404.149702.77810K562NELFE
MMACHCENSG00000132763.10183.77680268.04010-0.544502.166001.44710K562RPS19
MMACHCENSG00000132763.10556.89280318.775000.804807.951606.15270K562SAFB
MMACHCENSG00000132763.10224.84030355.02690-0.659003.520602.42010K562SF3B1
MMACHCENSG00000132763.10102.60170221.15190-1.108003.891702.34300K562SNRNP200
MMACHCENSG00000132763.10277.17730161.894000.775704.864703.93140K562SRSF1
MMACHCENSG00000132763.10387.04990573.71040-0.567803.796802.29240K562STAU1
MMACHCENSG00000132763.10118.18140264.55640-1.162604.719402.68580K562SUPT6H
MMACHCENSG00000132763.10614.52840358.850300.776008.790207.32780K562SYNCRIP
MMACHCENSG00000132763.10145.55690232.25490-0.674103.216001.39480K562TFIP11
MMACHCENSG00000132763.10288.56510398.27980-0.464902.343901.53700K562WDR3
MMACHCENSG00000132763.10138.01030260.28690-0.915303.073101.38150K562YTHDC2
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for MMACHC is not available on ENCORE database.





3 RBPs can affect the splicing of MMACHC :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEMMACHCENSG00000132763.10chr1+4597302745973222459657244596608545973883459740360.247000.000900.03453includedK562PRPF8
SEMMACHCENSG00000132763.10chr1+459730274597322245965724459660854597388345974036-0.328000.000000.00080excludedK562LARP7
SEMMACHCENSG00000132763.10chr1+459730274597322245965724459660854597388345974036-0.203000.000640.01321excludedK562HNRNPC

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for MMACHC is not avaliable on ENCORE database.