LEF1

General Information

Gene Name       : LEF1
Gene ID             : ENSG00000138795.9
Essential Gene : No

Functions

Localization

Domains (AlphaFold: LEF1)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878LEF1ENSG00000138795.933.8225.9129.87ENCSR000AEF
HepG2LEF1ENSG00000138795.90.630.660.65ENCSR985KAT
K562LEF1ENSG00000138795.943.8254.5249.17ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for LEF1 is not avaliable on ENCORE database.



Proteins bound to RNA
  • LEF1 RNA is bound by 2 proteins.  







eCLIP assay for LEF1 is not avaliable on ENCORE database.





2 proteins are bound to LEF1 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr4109088631109088712-CDS,intron-Distal4.638506.77156K562AQR
chr4108992930108993082-intron-Distal,intron-Proximal3.365153.69826K562TARDBP
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for LEF1 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for LEF1 is not available on ENCORE database.

  • 56 RBPs can affect the levels of LEF1.  








The Knockdown/knockout RNA-Seq assay for LEF1 is not available on ENCORE database.





56 RBPs can affect the gene expression of LEF1 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
LEF1ENSG00000138795.515.961001.165403.775502.604802.08790HepG2AKAP1
LEF1ENSG00000138795.5263.3687013.391104.2976037.1373034.54110HepG2CNOT7
LEF1ENSG00000138795.543.3186017.981301.268402.275701.64420HepG2CPSF6
LEF1ENSG00000138795.543.1632011.946801.853102.331101.73240HepG2CELF1
LEF1ENSG00000138795.513.555000.992103.772102.346601.71070HepG2EIF4B
LEF1ENSG00000138795.536.4779011.034301.724902.300301.59520HepG2FIP1L1
LEF1ENSG00000138795.517.138001.029904.056503.425902.66110HepG2FXR1
LEF1ENSG00000138795.53.0873020.38850-2.723302.670602.03970HepG2GPKOW
LEF1ENSG00000138795.548.3752013.157301.878303.729802.93430HepG2HNRNPC
LEF1ENSG00000138795.56.7576026.39900-1.965902.957902.21720HepG2HNRNPF
LEF1ENSG00000138795.54.3454019.45670-2.162701.990801.44820HepG2HNRNPLL
LEF1ENSG00000138795.57.5561025.99450-1.782502.591701.89100HepG2IGF2BP1
LEF1ENSG00000138795.544.6888012.730101.811604.382903.42420HepG2NOL12
LEF1ENSG00000138795.552.467402.160704.6018012.3885011.39520HepG2PTBP1
LEF1ENSG00000138795.544.3568010.331202.102004.527203.90710HepG2RBM22
LEF1ENSG00000138795.527.751506.660702.058702.672002.06690HepG2RPS19
LEF1ENSG00000138795.523.937304.198302.511303.513202.75000HepG2SF3A3
LEF1ENSG00000138795.514.845102.246802.723902.236501.69760HepG2SF3B4
LEF1ENSG00000138795.57.9442025.93960-1.707202.430201.77490HepG2SRSF7
LEF1ENSG00000138795.543.195903.723203.536208.789307.66350HepG2UPF1
LEF1ENSG00000138795.51083.19600813.528500.412903.418502.09060K562AARS
LEF1ENSG00000138795.51354.426501667.94160-0.300402.457401.53950K562AKAP8
LEF1ENSG00000138795.51071.832401579.51130-0.559406.749105.69310K562AKAP8L
LEF1ENSG00000138795.5762.84100994.80080-0.383002.787502.19730K562AQR
LEF1ENSG00000138795.5433.04140587.74000-0.440703.929002.77090K562BCLAF1
LEF1ENSG00000138795.5614.791901010.77140-0.717305.922004.63380K562BOP1
LEF1ENSG00000138795.51383.341201673.06920-0.274302.187301.32180K562CELF1
LEF1ENSG00000138795.51198.007701781.01370-0.572106.817504.52050K562DDX19B
LEF1ENSG00000138795.5501.48900703.85050-0.489103.755802.17350K562DNAJC21
LEF1ENSG00000138795.5967.214601360.82880-0.492606.536305.11380K562EIF4G2
LEF1ENSG00000138795.51045.44880772.762300.435903.137501.92230K562FKBP4
LEF1ENSG00000138795.5753.442201093.48050-0.537403.643502.65800K562FMR1
LEF1ENSG00000138795.5474.53800926.78490-0.9657010.930008.98350K562FTO
LEF1ENSG00000138795.5739.04990506.475900.545105.812504.98330K562FXR1
LEF1ENSG00000138795.5630.40990994.32360-0.657409.621407.60720K562GLRX3
LEF1ENSG00000138795.5571.310301026.19250-0.845009.246507.78640K562GPKOW
LEF1ENSG00000138795.5756.900101115.48470-0.559506.031204.90960K562GRSF1
LEF1ENSG00000138795.5552.35710890.25400-0.688607.752306.79950K562HNRNPC
LEF1ENSG00000138795.5574.95370794.95810-0.467403.756302.40640K562HNRNPF
LEF1ENSG00000138795.5888.243301459.53180-0.716503.218201.66870K562ILF2
LEF1ENSG00000138795.5415.83200683.79200-0.717606.320104.08250K562ILF3
LEF1ENSG00000138795.5595.01540876.14450-0.558203.511502.44530K562KRR1
LEF1ENSG00000138795.51238.87000861.977700.523205.597003.52510K562LARP7
LEF1ENSG00000138795.51067.59480665.544200.681706.271704.98570K562MAGOH
LEF1ENSG00000138795.51061.384601450.53600-0.450603.900202.56240K562MSI2
LEF1ENSG00000138795.5786.668401045.39200-0.410205.020303.95700K562MTPAP
LEF1ENSG00000138795.5923.187101161.57790-0.331404.536903.61000K562NSUN2
LEF1ENSG00000138795.51057.470001535.46140-0.538102.542101.37190K562PABPC1
LEF1ENSG00000138795.5867.635001404.27210-0.694702.871102.03430K562PPIG
LEF1ENSG00000138795.5961.47460646.610000.572306.633805.64040K562PTBP1
LEF1ENSG00000138795.5921.837901547.41420-0.7473014.2750012.11430K562PUM2
LEF1ENSG00000138795.5867.94480631.705100.458303.155502.07710K562RPS3
LEF1ENSG00000138795.51251.71450848.535000.560806.422104.77900K562SAFB
LEF1ENSG00000138795.5794.954401146.10140-0.527807.595606.29660K562SF3A3
LEF1ENSG00000138795.5941.93350690.315900.448303.646602.42180K562SRFBP1
LEF1ENSG00000138795.5823.18490633.881700.376902.928602.20430K562SRSF1
LEF1ENSG00000138795.5949.225001485.00480-0.645602.510201.32190K562STAU1
LEF1ENSG00000138795.5785.461501424.95720-0.859304.747502.59880K562STIP1
LEF1ENSG00000138795.51678.56030955.185600.813308.848707.37930K562SYNCRIP
LEF1ENSG00000138795.5370.60790641.55490-0.791707.825606.55940K562TARDBP
LEF1ENSG00000138795.51000.426201272.78190-0.347404.198502.63510K562TROVE2
LEF1ENSG00000138795.5873.728401231.64140-0.495308.080206.93140K562UPF1
LEF1ENSG00000138795.5857.187801053.88360-0.298002.237801.45150K562WDR3
LEF1ENSG00000138795.5727.140001120.72960-0.624107.320605.80030K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for LEF1 is not available on ENCORE database.





20 RBPs can affect the splicing of LEF1 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SELEF1ENSG00000138795.5chr4-1090027411090028251090006471090007701090045111090046020.532000.000000.00000includedK562SRSF1
SELEF1ENSG00000138795.5chr4-1089847781089848191089687001089699071089854911089855400.397000.000000.00000includedK562SRSF1
SELEF1ENSG00000138795.5chr4-109002741109002825109000647109000770109004511109004602-0.199000.003290.05367excludedK562SF3B4
SELEF1ENSG00000138795.5chr4-108984778108984819108968700108969907108985491108985676-0.306000.000160.00465excludedK562SF3B4
SELEF1ENSG00000138795.5chr4-1090027411090028251090006471090007701090045111090046020.210000.000090.02870includedK562WDR3
SELEF1ENSG00000138795.5chr4-109002741109002825109000647109000770109004511109004602-0.194000.000000.00019excludedK562AKAP8L
SELEF1ENSG00000138795.5chr4-1090027411090028251090006471090007701090045111090046020.205000.000000.00143includedK562PUM1
SELEF1ENSG00000138795.5chr4-109002741109002825109000647109000770109004511109004602-0.237000.000000.00000excludedK562LIN28B
SELEF1ENSG00000138795.5chr4-109002741109002825109000647109000770109004511109004602-0.228000.000000.00000excludedK562WDR43
SELEF1ENSG00000138795.5chr4-109002741109002825109000647109000770109004511109004602-0.232000.000000.00008excludedK562AQR
SELEF1ENSG00000138795.5chr4-108984778108984819108968700108969907108985491108985559-0.338000.000000.00004excludedK562AQR
SELEF1ENSG00000138795.5chr4-109002741109002825109000647109000770109004511109004602-0.197000.000000.00040excludedK562FXR1
SELEF1ENSG00000138795.5chr4-1090027411090028251090006471090007701090045111090046020.191000.000000.00048includedK562DROSHA
SELEF1ENSG00000138795.5chr4-109002741109002825109000647109000770109004511109004602-0.229000.000000.00000excludedK562PUS1
SELEF1ENSG00000138795.5chr4-1090027411090028251090006471090007701090045111090046640.154000.000370.05514includedK562HNRNPM
SELEF1ENSG00000138795.5chr4-109002741109002825109000647109000770109004511109004602-0.122000.000270.02393excludedK562HNRNPL
SELEF1ENSG00000138795.5chr4-109002741109002825109000647109000770109004511109004602-0.139000.000100.07203excludedK562LARP7
SELEF1ENSG00000138795.5chr4-1090027411090028251090006471090007701090045111090046020.240000.000000.00015includedK562UPF1
SELEF1ENSG00000138795.5chr4-109002741109002825109000647109000770109004511109004602-0.199000.000000.00047excludedK562TARDBP
SELEF1ENSG00000138795.5chr4-109002741109002825109000647109000770109004511109004602-0.158000.000070.00337excludedK562RBM15
SELEF1ENSG00000138795.5chr4-108984778108984819108968700108969907108985491108985540-0.166000.001360.03444excludedK562RBM15
SELEF1ENSG00000138795.5chr4-1090027411090028251090006471090007701090045111090046020.286000.000000.00000includedK562CPSF6
SELEF1ENSG00000138795.5chr4-108984778108984819108968700108969907108985491108985540-0.328000.001570.05712excludedK562SF3B1
SELEF1ENSG00000138795.5chr4-1090027411090028251090006471090007701090045111090046020.319000.000000.00009includedK562PTBP1
A3SSLEF1ENSG00000138795.5chr4-1089854911089855591089854911089855401089918181089919260.117000.000390.00302longerK562AQR
A3SSLEF1ENSG00000138795.5chr4-1089847781089848871089847781089848191089854911089855590.127000.009910.05247longerK562AQR
A3SSLEF1ENSG00000138795.5chr4-1089994801089996301089994801089995381090006471090007700.081000.000000.00000longerK562AQR
MXELEF1ENSG00000138795.5chr4-108985491108985540108991818108991926108968700108969907108999375108999538-0.205000.000290.003072includedK562AQR

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for LEF1 is not avaliable on ENCORE database.