ADAM17

General Information

Gene Name       : ADAM17
Gene ID             : ENSG00000151694.13
Essential Gene : No

Functions

Localization

Domains (AlphaFold: ADAM17)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878ADAM17ENSG00000151694.138.428.168.29ENCSR000AEF
HepG2ADAM17ENSG00000151694.1312.3915.9714.18ENCSR985KAT
K562ADAM17ENSG00000151694.1315.5114.8715.19ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for ADAM17 is not avaliable on ENCORE database.



Proteins bound to RNA
  • ADAM17 RNA is bound by 27 proteins.  







eCLIP assay for ADAM17 is not avaliable on ENCORE database.





27 proteins are bound to ADAM17 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr296289269628982-3'-UTR,intron-Distal3.761434.24288K562UPF1
chr296292189629269-3'-UTR,intron-Distal3.510183.95400K562UPF1
chr296291569629266-3'-UTR,intron-Distal3.861185.40194HepG2FAM120A
chr296625449662609-3'-UTR,CDS,intron-Distal3.408863.16095HepG2U2AF2
chr296287309628800-3'-UTR,intron-Distal4.715379.61624K562TARDBP
chr296288929628987-3'-UTR,intron-Distal3.718577.47553K562FAM120A
chr296288629628970-3'-UTR,intron-Distal3.578324.70908HepG2QKI
chr296957429695891-5'-UTR,intron-Distal3.703197.93865HepG2NCBP2
chr296338099633903-CDS,intron-Distal,intron-Proximal4.149346.35873K562PRPF8
chr296582419658300-CDS,intron-Distal3.395364.74886HepG2BCLAF1
chr296633919663458-CDS,intron-Distal3.615265.45876HepG2BCLAF1
chr296663199666368-CDS,intron-Distal3.153764.61799HepG2BCLAF1
chr296423039642393-CDS,intron-Distal5.062486.46301HepG2PPIG
chr296304929630571-CDS,intron-Distal3.315575.65349K562UCHL5
chr296371939637247-CDS,intron-Distal,intron-Proximal4.493244.27476HepG2AQR
chr296452979645409-CDS,intron-Distal3.189887.10910K562UCHL5
chr296371769637244-CDS,intron-Distal,intron-Proximal5.621126.75320K562AQR
chr296679129667974-CDS,intron-Distal,intron-Proximal5.416558.86847HepG2BCLAF1
chr296348309634883-CDS,intron-Distal3.704034.41621HepG2PRPF8
chr296580349658083-CDS,intron-Distal3.427915.56491HepG2BCLAF1
chr296614269661445-CDS,intron-Distal3.720393.87469HepG2BCLAF1
chr296662469666317-CDS,intron-Distal3.997797.89209HepG2BCLAF1
chr296453029645398-CDS,intron-Distal3.206086.24463HepG2GRWD1
chr296662399666323-CDS,intron-Distal,intron-Proximal3.259367.92361K562ZNF622
chr296372039637267-CDS,intron-Distal,intron-Proximal3.474668.18981HepG2PRPF8
chr296312209631286-CDS,intron-Distal,intron-Proximal3.045685.96307K562BUD13
chr296312689631322-CDS,intron-Distal,intron-Proximal3.804245.44908K562SF3B4
chr296613999661493-CDS,intron-Distal,intron-Proximal3.144045.09479K562SF3B4
chr296613309661369-CDS,intron-Distal,intron-Proximal4.042326.22576HepG2BCLAF1
chr296453019645439-CDS,intron-Distal3.8103110.86716K562ZNF622
chr296372109637245-CDS,intron-Distal,intron-Proximal4.042723.44423K562BUD13
chr296613719661426-CDS,intron-Distal4.427588.15024HepG2BCLAF1
chr296330259633059-CDS,intron-Distal,intron-Proximal3.333623.07653K562ZNF622
chr296453259645410-CDS,intron-Distal4.206118.94445HepG2BCLAF1
chr296768269676856-CDS,intron-Distal,intron-Proximal4.877105.23259HepG2BCLAF1
chr296768569676894-CDS,intron-Distal3.761624.09885HepG2BCLAF1
chr296614059661482-CDS,intron-Distal,intron-Proximal4.235735.01214HepG2BUD13
chr296330269633109-CDS,intron-Distal,intron-Proximal3.405537.29897K562DDX24
chr296612889661355-CDS,intron-Distal,intron-Proximal3.912884.39974K562GPKOW
chr296769229677062-CDS,intron-Distal,intron-Proximal3.531858.24998K562KHSRP
chr296422459642318-CDS,intron-Distal,intron-Proximal4.945565.26064K562AQR
chr296339069633967-CDS,intron-Distal,intron-Proximal3.672655.51703K562BUD13
chr296501339650210-CDS,intron-Distal3.089066.02234K562UCHL5
chr296633869663435-CDS,intron-Distal3.436843.66187K562ZNF622
chr296311949631251-CDS,intron-Distal,intron-Proximal3.504973.86335K562SF3B4
chr296372429637333-CDS,intron-Distal,intron-Proximal4.760666.01390HepG2GRWD1
chr296779549678069-intron-Distal5.8464510.50585HepG2DDX59
chr296578429657921-intron-Distal3.544635.35459K562KHSRP
chr296779529678024-intron-Distal4.553079.64289HepG2PCBP2
chr296632179663250-intron-Distal3.119053.57533K562KHSRP
chr296311749631220-intron-Distal,intron-Proximal3.335203.65452K562BUD13
chr296770629677086-intron-Distal4.487664.54401K562KHSRP
chr296779789678042-intron-Distal3.925383.31570HepG2HNRNPK
chr296952509695354-intron-Distal3.455617.08576K562CSTF2T
chr296839279683950-intron-Distal4.9832912.43246K562QKI
chr296661279666205-intron-Distal,intron-Proximal4.176913.02181K562PRPF8
chr296780439678114-intron-Distal4.711693.77881HepG2PCBP2
chr296779289678029-intron-Distal4.879577.69017K562ILF3
chr296839509683984-intron-Distal4.052273.84727K562QKI
chr296838819683927-intron-Distal5.4988113.79808K562QKI
chr296952449695347-intron-Distal3.742396.87708HepG2EFTUD2
chr296613239661331-intron-Distal,intron-Proximal4.792568.69247K562AQR
chr296839499684094-intron-Distal3.265607.68025K562KHSRP
chr296838729683972-intron-Distal4.5982210.60267HepG2QKI
chr296631409663210-intron-Distal4.425215.10338HepG2KHSRP
chr296612889661323-intron-Distal,intron-Proximal4.8957910.24966K562AQR
chr296952749695346-intron-Distal4.749736.08953K562EXOSC5
chr296881499688205-intron-Distal3.845793.21162HepG2HNRNPC
chr296952379695410-intron-Distal4.146644.56225K562FUS
chr296632509663270-intron-Distal4.199063.89294K562KHSRP
chr296549599655011-intron-Distal3.647833.00349HepG2ILF3
chr296954779695556-intron-Distal4.071406.10859HepG2EFTUD2
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for ADAM17 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for ADAM17 is not available on ENCORE database.

  • 87 RBPs can affect the levels of ADAM17.  








The Knockdown/knockout RNA-Seq assay for ADAM17 is not available on ENCORE database.





87 RBPs can affect the gene expression of ADAM17 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
ADAM17ENSG00000151694.81147.18580860.070300.415505.825905.00730HepG2ACO1
ADAM17ENSG00000151694.81729.542701328.021400.381002.435001.93270HepG2AKAP1
ADAM17ENSG00000151694.81467.60550864.126900.7640017.6217015.91680HepG2AKAP8L
ADAM17ENSG00000151694.81581.408501098.846000.525104.833503.80830HepG2ASCC1
ADAM17ENSG00000151694.81517.244001298.713700.224302.158701.53860HepG2AUH
ADAM17ENSG00000151694.8667.17400905.03300-0.439902.372201.50620HepG2BCCIP
ADAM17ENSG00000151694.81630.994201131.455300.527505.865405.03290HepG2BOP1
ADAM17ENSG00000151694.81379.641601042.754500.403804.138303.21940HepG2CALR
ADAM17ENSG00000151694.82630.614801630.020700.690406.053404.58370HepG2CCAR1
ADAM17ENSG00000151694.81442.953601043.972900.466804.020503.09780HepG2CIRBP
ADAM17ENSG00000151694.81019.92890859.902300.246102.399501.77190HepG2CKAP4
ADAM17ENSG00000151694.81647.672701038.743500.665508.301307.16280HepG2CPSF6
ADAM17ENSG00000151694.8541.881001260.31880-1.2177027.0519025.18230HepG2DAZAP1
ADAM17ENSG00000151694.81096.09620824.445800.410803.353102.61130HepG2DDX21
ADAM17ENSG00000151694.81308.75810806.515100.6983010.003508.31780HepG2DDX24
ADAM17ENSG00000151694.81621.020601272.186400.349502.369401.78550HepG2DDX3X
ADAM17ENSG00000151694.81753.618901179.567600.572002.929901.92490HepG2DDX59
ADAM17ENSG00000151694.8728.832601092.73470-0.584304.544703.76960HepG2DDX6
ADAM17ENSG00000151694.8723.25810913.27010-0.336503.858903.11530HepG2DNAJC2
ADAM17ENSG00000151694.81101.38260686.528100.681806.772805.40830HepG2EIF3D
ADAM17ENSG00000151694.81055.867701243.23900-0.235702.310601.53410HepG2EIF4G1
ADAM17ENSG00000151694.82807.472901491.096700.9128032.9610031.28980HepG2ETF1
ADAM17ENSG00000151694.8527.60420719.25430-0.447003.362502.50040HepG2FUBP3
ADAM17ENSG00000151694.81505.735701061.848300.503803.095101.91320HepG2FUS
ADAM17ENSG00000151694.81430.516201086.636800.396602.763102.09860HepG2G3BP1
ADAM17ENSG00000151694.81187.18890953.215000.316602.226401.31740HepG2GNB2L1
ADAM17ENSG00000151694.81040.78340821.132400.341903.797802.66790HepG2HDGF
ADAM17ENSG00000151694.81536.440001100.140200.481804.600203.71840HepG2HNRNPK
ADAM17ENSG00000151694.8942.055601148.10430-0.285403.532802.77800HepG2HNRNPL
ADAM17ENSG00000151694.8503.66510753.09400-0.580405.577804.27930HepG2HNRNPM
ADAM17ENSG00000151694.8776.478801027.91410-0.404704.970304.17760HepG2HNRNPU
ADAM17ENSG00000151694.8793.831001035.88700-0.384003.390102.59500HepG2IGF2BP1
ADAM17ENSG00000151694.81466.155501171.716900.323302.090201.51710HepG2MAGOH
ADAM17ENSG00000151694.82067.105301178.298500.810809.608908.49190HepG2MATR3
ADAM17ENSG00000151694.81396.25800883.388900.660308.816507.44940HepG2MSI2
ADAM17ENSG00000151694.8711.571101146.01360-0.687504.758403.46670HepG2MTPAP
ADAM17ENSG00000151694.81566.963301249.720700.326303.123402.31420HepG2NOL12
ADAM17ENSG00000151694.81471.66030958.177300.619003.441702.44420HepG2PABPC1
ADAM17ENSG00000151694.8844.127101118.86680-0.406505.142304.35570HepG2PCBP1
ADAM17ENSG00000151694.8955.70990806.036300.245602.092201.41130HepG2PRPF4
ADAM17ENSG00000151694.82712.391301265.393701.0999032.0591029.95910HepG2PUM2
ADAM17ENSG00000151694.81026.749001233.02240-0.264102.168001.60340HepG2QKI
ADAM17ENSG00000151694.8917.742401160.83460-0.339003.037202.14110HepG2RBM15
ADAM17ENSG00000151694.81913.644401246.281000.6186011.9712011.04940HepG2RBM22
ADAM17ENSG00000151694.81623.193501119.038700.536506.737705.72630HepG2RBM25
ADAM17ENSG00000151694.8901.82820679.126900.409102.585801.82360HepG2RRP9
ADAM17ENSG00000151694.81117.42240915.413100.287603.126502.45010HepG2SAFB2
ADAM17ENSG00000151694.82540.320701169.126701.1195014.3189012.71850HepG2SF3A3
ADAM17ENSG00000151694.8898.805701067.54340-0.248202.340401.74210HepG2SMN1
ADAM17ENSG00000151694.82670.685301237.593301.1096012.2080010.57760HepG2SNRNP70
ADAM17ENSG00000151694.82704.307701407.628700.9419038.6946037.38730HepG2SRFBP1
ADAM17ENSG00000151694.81675.372101237.211500.437307.164406.48680HepG2SRSF1
ADAM17ENSG00000151694.81789.359801196.780800.580204.704703.36600HepG2SRSF3
ADAM17ENSG00000151694.81897.117301177.771800.6876016.3251014.98200HepG2SRSF5
ADAM17ENSG00000151694.8865.471801033.51480-0.256002.243801.61000HepG2SRSF7
ADAM17ENSG00000151694.81636.793901006.530900.7014011.1447010.16810HepG2SRSF9
ADAM17ENSG00000151694.82014.787201339.506400.5888014.4886013.24710HepG2SUCLG1
ADAM17ENSG00000151694.81426.36840885.828800.687106.768905.78440HepG2SUPV3L1
ADAM17ENSG00000151694.81828.285901112.032800.7172015.3105014.15030HepG2TAF15
ADAM17ENSG00000151694.8820.381101007.73510-0.296802.923602.34780HepG2TRIM56
ADAM17ENSG00000151694.81519.024801165.346000.382303.539002.53730HepG2TUFM
ADAM17ENSG00000151694.8773.013001065.72330-0.463305.872804.39950HepG2UTP18
ADAM17ENSG00000151694.81974.036101001.025100.9796033.4958031.76600HepG2UTP3
ADAM17ENSG00000151694.8642.38540953.85020-0.570303.330601.92910HepG2XRCC5
ADAM17ENSG00000151694.8582.26930872.00040-0.582604.315103.41510HepG2XRN2
ADAM17ENSG00000151694.81105.76440795.419600.475207.528806.50860HepG2ZC3H8
ADAM17ENSG00000151694.81789.983702175.59500-0.281502.969402.02480K562ATP5C1
ADAM17ENSG00000151694.81327.322301587.36670-0.258102.600701.52820K562CPEB4
ADAM17ENSG00000151694.8563.04210705.84890-0.326102.283801.34180K562CSTF2
ADAM17ENSG00000151694.81203.56890878.640300.453903.138002.03130K562EIF3D
ADAM17ENSG00000151694.8742.80300983.21620-0.404503.645302.16440K562EXOSC5
ADAM17ENSG00000151694.81001.307301243.59650-0.312602.237801.47440K562FIP1L1
ADAM17ENSG00000151694.81458.252501000.866700.542903.904603.02960K562G3BP2
ADAM17ENSG00000151694.81049.869601640.31870-0.643809.112207.72000K562GRSF1
ADAM17ENSG00000151694.8650.27870840.53390-0.370202.670202.08180K562HNRNPC
ADAM17ENSG00000151694.8824.087501198.24390-0.540108.781507.41660K562MTPAP
ADAM17ENSG00000151694.81167.83400937.605300.316702.696901.48410K562NCBP2
ADAM17ENSG00000151694.81167.011701331.33250-0.190101.964401.32230K562NSUN2
ADAM17ENSG00000151694.8916.314001250.65100-0.448803.340202.42650K562PCBP3
ADAM17ENSG00000151694.8764.77020959.33210-0.327002.207001.49210K562POLR2G
ADAM17ENSG00000151694.8575.83050753.62710-0.388202.428401.58680K562PSIP1
ADAM17ENSG00000151694.8995.96950683.339900.543403.114201.44590K562SERBP1
ADAM17ENSG00000151694.81340.187701041.292300.364003.736502.73800K562SF3B4
ADAM17ENSG00000151694.81661.043801345.939000.303404.322303.18000K562SRPK2
ADAM17ENSG00000151694.81265.02810926.065300.449905.813103.82870K562SSB
ADAM17ENSG00000151694.8901.567301194.20170-0.405503.196902.43700K562TARDBP
ADAM17ENSG00000151694.8511.60540724.86300-0.502703.437802.39000K562TIAL1
ADAM17ENSG00000151694.81622.556601002.419300.6947012.1809010.48020K562U2AF2
ADAM17ENSG00000151694.8896.911601207.89430-0.429504.261903.16660K562WDR3
ADAM17ENSG00000151694.81594.314901943.23520-0.285502.269801.50080K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for ADAM17 is not available on ENCORE database.





7 RBPs can affect the splicing of ADAM17 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEADAM17ENSG00000151694.8chr2-964230196424059637143963737796452949645494-0.053000.009170.07582excludedK562AQR
A3SSADAM17ENSG00000151694.8chr2-966623996663939666239966637396679149668083-0.182000.000000.00022shorterK562FXR1
A3SSADAM17ENSG00000151694.8chr2-9631229963130996312299631280963302696331540.185000.000020.00022longerK562AQR
A3SSADAM17ENSG00000151694.8chr2-9661331966157996613319661445966337796635370.173000.000000.00000longerK562AQR
A3SSADAM17ENSG00000151694.8chr2-9667914966813796679149668083967596296761680.196000.000000.00000longerK562AQR
A3SSADAM17ENSG00000151694.8chr2-9661331966152096613319661445966337796634670.120000.000000.00010longerK562PUS1
A3SSADAM17ENSG00000151694.8chr2-9666239966639396662399666373966791496680830.158000.000190.01228longerK562PUS1
A3SSADAM17ENSG00000151694.8chr2-9666239966639396662399666373966791496680830.142000.000660.08542longerK562UTP18
A3SSADAM17ENSG00000151694.8chr2-966623996663939666239966637396679149668083-0.165000.000520.08059shorterK562PTBP1
A3SSADAM17ENSG00000151694.8chr2-9666239966639396662399666373966791496680830.141000.000400.04709longerK562RBM15
MXEADAM17ENSG00000151694.8chr2-96452949645494965010796502609637242963737796580299658118-0.072000.000190.002082includedK562AQR
MXEADAM17ENSG00000151694.8chr2-964230196424059645294964549496372429637377965010796502600.136000.000190.044791includedK562PUM2

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for ADAM17 is not avaliable on ENCORE database.