MADD

General Information

Gene Name       : MADD
Gene ID             : ENSG00000110514.19
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: MADD)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878MADDENSG00000110514.1910.5915.5513.07ENCSR000AEF
HepG2MADDENSG00000110514.1922.6820.0721.38ENCSR985KAT
K562MADDENSG00000110514.1930.0328.1729.10ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for MADD is not avaliable on ENCORE database.



Proteins bound to RNA
  • MADD RNA is bound by 28 proteins.  







eCLIP assay for MADD is not avaliable on ENCORE database.





28 proteins are bound to MADD RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr114735085747350928+3'-UTR3.734403.11149HepG2G3BP1
chr114735148647351572+3'-UTR6.4364715.61756K562PUM2
chr114734654147346627+3'-UTR,intron-Distal4.293294.39969K562TARDBP
chr114735099747351155+3'-UTR4.6651010.58184K562UPF1
chr114735144047351503+3'-UTR4.634145.24231K562UPF1
chr114735101847351082+3'-UTR3.802723.19668HepG2UPF1
chr114735083547350970+3'-UTR4.054228.62096K562UPF1
chr114735122047351353+3'-UTR4.337858.17454K562UPF1
chr114735092347350977+3'-UTR4.445429.14508K562PUM2
chr114729173447291799+5'-UTR,intron-Distal,intron-Proximal4.733923.69821K562DDX3X
chr114731704647317111+5'-UTR,CDS,intron-Proximal4.939936.46301HepG2PPIG
chr114731549847315535+5'-UTR,CDS,intron-Proximal3.022404.03389K562ZNF622
chr114733686747336915+CDS,intron-Proximal3.761874.23459K562PRPF8
chr114734604447346111+CDS3.051064.37507K562DDX24
chr114731184147311892+CDS,intron-Proximal3.649695.32296K562PRPF8
chr114729977647299830+CDS,intron-Proximal3.138484.69671HepG2PPIG
chr114731150747311597+CDS3.463084.92880K562ZNF622
chr114730808347308094+CDS,intron-Distal,intron-Proximal4.153074.52312K562AQR
chr114730808347308171+CDS,intron-Distal,intron-Proximal3.436605.83656K562PRPF8
chr114731099347311045+CDS,intron-Proximal3.302115.04943K562ZNF622
chr114730312747303151+CDS4.080343.02457HepG2BCLAF1
chr114733100247331074+CDS,intron-Proximal3.200714.62757K562SF3B4
chr114734612847346180+CDS,intron-Proximal5.582407.81430K562AQR
chr114733686747336919+CDS,intron-Proximal3.994284.75655HepG2PRPF8
chr114731739447317451+CDS,intron-Proximal4.950195.32775HepG2SF3B4
chr114730800347308098+CDS,intron-Distal,intron-Proximal4.189036.95612HepG2PRPF8
chr114731738847317486+CDS,intron-Proximal3.806168.87150K562SF3B4
chr114729670947296756+CDS,intron-Distal,intron-Proximal4.895795.26064K562AQR
chr114734603047346114+CDS4.343606.36347HepG2PPIG
chr114733328447333371+CDS3.299453.73413HepG2PPIG
chr114731218847312270+CDS4.578288.51520K562DDX24
chr114729979647299829+CDS4.808003.25266K562DDX24
chr114730394547303996+CDS3.059404.03389K562ZNF622
chr114731742847317498+CDS,intron-Proximal3.543247.14018K562BUD13
chr114731752247317607+CDS,intron-Proximal4.277325.37961K562YBX3
chr114731739247317476+CDS,intron-Proximal5.5804111.24457HepG2SF3A3
chr114729619547296261+CDS,intron-Distal3.343633.93112K562RBM15
chr114731742847317476+CDS,intron-Proximal3.475904.41130K562AQR
chr114733328147333359+CDS,intron-Proximal3.953507.34123K562DDX24
chr114734583847345882+CDS3.223453.32039HepG2PPIG
chr114733020147330247+CDS3.623684.13746HepG2PPIG
chr114731710447317185+CDS,intron-Proximal4.344678.31500HepG2PRPF8
chr114731216047312246+CDS,intron-Proximal4.6481011.84897K562PUM2
chr114733024147330298+CDS,intron-Proximal3.536796.35344K562PRPF8
chr114731220247312263+CDS3.523903.05460HepG2PPIG
chr114731181947311900+CDS,intron-Proximal4.562938.11807HepG2PRPF8
chr114731097747311034+CDS3.198025.33841K562DDX24
chr114731177847311851+CDS,intron-Proximal3.241315.79197K562LIN28B
chr114733115747331214+CDS,intron-Proximal3.000897.03081K562AQR
chr114731736847317489+CDS,intron-Proximal3.493986.70028K562SMNDC1
chr114731215847312245+CDS,intron-Proximal4.324693.35081HepG2G3BP1
chr114733339147333440+CDS,intron-Proximal4.286596.01372K562AQR
chr114731141847311456+CDS3.891863.38114HepG2GRWD1
chr114731172647311789+CDS3.463085.04943K562ZNF622
chr114731141547311509+CDS,intron-Proximal3.343605.21025HepG2PPIG
chr114731142147311481+CDS3.936844.82082K562ZNF622
chr114731712147317170+CDS,intron-Proximal4.221836.48405K562AQR
chr114734839047348439+intron-Distal,intron-Proximal3.442173.54718K562PRPF8
chr114729181347291874+intron-Distal,intron-Proximal3.865873.43867K562CSTF2T
chr114729206547292131+intron-Distal4.539844.84986K562GTF2F1
chr114734890347348939+intron-Distal3.554953.76553K562PRPF8
chr114729206847292145+intron-Distal4.090083.63902HepG2CSTF2T
chr114729206847292144+intron-Distal3.493904.18553HepG2NKRF
chr114731105147311165+intron-Distal,intron-Proximal3.321665.48095K562PRPF8
chr114730811047308157+intron-Distal,intron-Proximal3.495956.35796K562AQR
chr114734910647349198+intron-Distal5.213097.72823K562PTBP1
chr114729205847292132+intron-Distal3.162243.68667HepG2FAM120A
chr114729205847292120+intron-Distal3.929123.86417HepG2PRPF4
chr114731531647315378+intron-Distal,intron-Proximal5.396876.40247K562SF3B4
chr114729796447298016+intron-Distal3.831154.89208K562AQR
chr114730817147308245+intron-Distal,intron-Proximal4.098685.64238K562PRPF8
chr114731010947310223+intron-Distal4.316035.08471HepG2HNRNPK
chr114729207347292145+intron-Distal3.763383.01994HepG2GTF2F1
chr114729207047292134+intron-Distal3.122803.17504K562CSTF2T
chr114729228547292356+intron-Distal4.711696.17200HepG2PCBP2
chr114730809447308110+intron-Distal,intron-Proximal5.353346.44303K562AQR
chr114730584147305913+intron-Proximal3.192913.60305HepG2SF3B4
chr114731695647317021+intron-Proximal3.783053.00258HepG2RBM5
chr114729775347297818+intron-Proximal3.699634.98672K562AQR
chr114730584947305918+intron-Proximal5.508078.71620K562SF3B4
chr114731104847311144+intron-Proximal4.9845611.65116K562AQR
chr114735025547350304+intron-Proximal4.492116.99120K562AQR
chr114731185147311894+intron-Proximal4.623634.09264K562AQR
chr114733025947330307+intron-Proximal5.012854.48002K562AQR
chr114730416747304218+intron-Proximal4.874884.09264K562AQR
chr114729982947299873+intron-Proximal4.998105.17615K562AQR
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for MADD is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for MADD is not available on ENCORE database.

  • 88 RBPs can affect the levels of MADD.  








The Knockdown/knockout RNA-Seq assay for MADD is not available on ENCORE database.





88 RBPs can affect the gene expression of MADD :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
MADDENSG00000110514.141233.308301663.76050-0.431903.344002.31230HepG2ABCF1
MADDENSG00000110514.142267.280101617.148700.487403.797803.18850HepG2AKAP1
MADDENSG00000110514.14848.299101383.71010-0.7059013.2300011.72180HepG2AKAP8L
MADDENSG00000110514.142447.268601893.272500.370206.456105.47720HepG2AUH
MADDENSG00000110514.14832.454601092.24470-0.391903.089202.46070HepG2BOP1
MADDENSG00000110514.14817.464901075.77120-0.396103.661802.79170HepG2CALR
MADDENSG00000110514.141101.431201273.80440-0.209802.124601.38620HepG2DDX19B
MADDENSG00000110514.14612.57750957.57690-0.644505.368603.64110HepG2DDX27
MADDENSG00000110514.142370.418001548.971300.613706.600505.67650HepG2DDX3X
MADDENSG00000110514.141643.791701138.673200.529602.627401.67680HepG2DDX59
MADDENSG00000110514.141046.491101376.89040-0.395903.163202.08900HepG2DDX5
MADDENSG00000110514.142346.252901330.915900.817809.742208.65900HepG2DDX6
MADDENSG00000110514.14778.382501317.74140-0.7595016.0569014.71640HepG2DKC1
MADDENSG00000110514.14832.826501120.68040-0.428303.141802.16400HepG2EEF2
MADDENSG00000110514.141985.381001279.126600.634206.879005.97270HepG2EIF2S1
MADDENSG00000110514.141297.900201617.06090-0.317203.611202.67600HepG2EIF4G1
MADDENSG00000110514.141891.234901549.013100.287902.227801.49150HepG2EIF4G2
MADDENSG00000110514.141125.892901441.12390-0.356102.884601.76980HepG2ESF1
MADDENSG00000110514.141091.652001345.79470-0.301902.433801.65170HepG2EWSR1
MADDENSG00000110514.142122.680001679.961500.337402.182701.49470HepG2FIP1L1
MADDENSG00000110514.14645.61590851.89690-0.400002.907001.60630HepG2FKBP4
MADDENSG00000110514.14893.971101126.70980-0.333802.473001.85990HepG2HNRNPA1
MADDENSG00000110514.141252.333301506.31130-0.266402.550901.64870HepG2HNRNPA2B1
MADDENSG00000110514.141787.150901340.322000.415003.679202.88290HepG2HNRNPK
MADDENSG00000110514.14802.030701084.70780-0.435603.292002.61140HepG2HNRNPLL
MADDENSG00000110514.14895.120701158.99790-0.372703.296502.26590HepG2HNRNPM
MADDENSG00000110514.14862.717201344.81290-0.640406.620705.61750HepG2IGF2BP2
MADDENSG00000110514.141035.331401258.99390-0.282203.127702.04530HepG2KIF1C
MADDENSG00000110514.14806.078901126.88910-0.483404.213202.71220HepG2LIN28B
MADDENSG00000110514.141059.690101427.05580-0.429403.224802.51740HepG2MAGOH
MADDENSG00000110514.14677.51970908.80740-0.423702.976401.30280HepG2MARK2
MADDENSG00000110514.141929.515301468.708400.393602.859802.21680HepG2NCBP2
MADDENSG00000110514.14759.46780961.83020-0.340802.239601.56390HepG2NSUN2
MADDENSG00000110514.142184.635401404.757300.637003.785402.73290HepG2PABPC1
MADDENSG00000110514.141019.340001365.51060-0.421806.030705.18950HepG2PCBP1
MADDENSG00000110514.14902.130501110.39740-0.299702.773502.03610HepG2PPIL4
MADDENSG00000110514.141240.204801551.41710-0.323002.540501.96650HepG2PUF60
MADDENSG00000110514.141965.904301646.956000.255304.168403.47250HepG2PUM1
MADDENSG00000110514.142258.410901645.716800.456506.714405.68630HepG2PUM2
MADDENSG00000110514.141000.031601402.93370-0.488408.710207.71920HepG2PUS1
MADDENSG00000110514.141277.224801504.79290-0.236601.907201.37350HepG2QKI
MADDENSG00000110514.141686.335201152.802400.548602.806002.09660HepG2RAVER1
MADDENSG00000110514.142180.266301784.311100.289002.964202.07870HepG2RBM15
MADDENSG00000110514.141423.656101816.83960-0.351804.230303.62450HepG2RBM22
MADDENSG00000110514.14997.793501294.04780-0.375102.702401.72040HepG2RBM27
MADDENSG00000110514.141244.119501440.24100-0.211201.880801.35890HepG2RECQL
MADDENSG00000110514.14692.66040885.22330-0.353902.579501.98440HepG2RPS19
MADDENSG00000110514.14950.277301544.00320-0.700303.715902.78900HepG2RPS3A
MADDENSG00000110514.14616.80370780.76400-0.340101.981101.30470HepG2RRP9
MADDENSG00000110514.14977.687501466.12840-0.584603.359201.64860HepG2SBDS
MADDENSG00000110514.141017.785901292.95200-0.345205.097504.26830HepG2SMN1
MADDENSG00000110514.141517.436301228.432600.304703.944403.30900HepG2SRSF9
MADDENSG00000110514.141158.901701781.66310-0.6205014.2696013.28650HepG2SSB
MADDENSG00000110514.141473.705001742.09640-0.241402.803502.17900HepG2SUCLG1
MADDENSG00000110514.14784.651701018.85640-0.376802.581501.92550HepG2SUPV3L1
MADDENSG00000110514.14636.279001209.79610-0.9270017.6840016.62130HepG2TIAL1
MADDENSG00000110514.141443.921201220.505600.242402.578602.03000HepG2TRIM56
MADDENSG00000110514.14796.71590601.813700.404602.345501.64510HepG2UCHL5
MADDENSG00000110514.14941.678901267.91160-0.429102.309601.34340HepG2XRCC6
MADDENSG00000110514.14754.723201002.95480-0.410203.192402.41610HepG2XRN2
MADDENSG00000110514.14776.509401334.52210-0.7812019.7125018.20890HepG2ZC3H8
MADDENSG00000110514.142126.864601520.469800.4841012.0592011.11810HepG2ZNF622
MADDENSG00000110514.142153.881502550.71500-0.244002.681401.78340K562ATP5C1
MADDENSG00000110514.141827.574401571.471700.217702.403401.51120K562BCLAF1
MADDENSG00000110514.143240.247902294.427500.497902.719801.67200K562CNOT7
MADDENSG00000110514.141100.658701378.03910-0.324203.729002.17150K562DDX27
MADDENSG00000110514.142462.475501555.816700.6623011.678409.37970K562DDX3X
MADDENSG00000110514.142024.394202469.87910-0.287002.609601.97430K562DDX47
MADDENSG00000110514.141891.638201506.410800.328402.406601.55670K562EFTUD2
MADDENSG00000110514.142070.522301709.023800.276703.535602.15070K562EIF2S1
MADDENSG00000110514.143173.009401965.410400.6909018.1200016.51320K562EIF2S2
MADDENSG00000110514.14882.385101232.40520-0.482002.463401.51930K562EIF3A
MADDENSG00000110514.143741.604603280.366500.189702.198401.35600K562EIF4G2
MADDENSG00000110514.142512.470101605.015600.646408.749407.18750K562FMR1
MADDENSG00000110514.14741.702901221.14400-0.719306.104904.96610K562G3BP2
MADDENSG00000110514.141917.041801505.889600.348203.176902.32830K562GPKOW
MADDENSG00000110514.142169.871402618.79950-0.271302.113301.44690K562GRSF1
MADDENSG00000110514.141951.196801603.917500.282702.417101.85420K562HNRNPC
MADDENSG00000110514.142733.853502231.952000.292502.729901.68390K562HNRNPL
MADDENSG00000110514.141856.476501469.940100.336703.042002.12180K562METAP2
MADDENSG00000110514.142316.895901623.091200.513307.930705.87470K562NCBP2
MADDENSG00000110514.142739.740402356.672700.217203.871903.00610K562NSUN2
MADDENSG00000110514.141810.885201477.689200.293302.411301.50060K562PCBP2
MADDENSG00000110514.142055.253302536.20380-0.303402.064801.34670K562PCBP3
MADDENSG00000110514.141563.151001945.33910-0.315603.121802.26760K562POLR2G
MADDENSG00000110514.142968.876802411.161500.300102.444101.92660K562PUS1
MADDENSG00000110514.141147.090101493.02450-0.380302.574901.78810K562RPS19
MADDENSG00000110514.141110.450501498.64670-0.432502.671501.36610K562RRP9
MADDENSG00000110514.142580.857801472.781400.809203.724202.26400K562SF1
MADDENSG00000110514.143206.422002325.615500.463309.168707.74990K562SF3A3
MADDENSG00000110514.143210.828701691.222300.924805.061003.23980K562SNRNP200
MADDENSG00000110514.142780.462802382.659700.222703.195602.19670K562SRPK2
MADDENSG00000110514.142707.848001581.891600.7754015.9305014.23690K562SRSF1
MADDENSG00000110514.141866.921901544.294100.273602.338301.59380K562TIA1
MADDENSG00000110514.141608.944301221.894400.396904.415403.40540K562U2AF2
MADDENSG00000110514.142011.606801502.003600.421403.616102.44020K562UCHL5
MADDENSG00000110514.142643.637902138.162500.306103.075002.15420K562WDR3
MADDENSG00000110514.143589.110202872.901300.321003.344701.91610K562WRN
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for MADD is not available on ENCORE database.





19 RBPs can affect the splicing of MADD :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEMADDENSG00000110514.14chr11+473079834730808547306491473067454731094147311044-0.157000.005540.07994excludedK562SF3B4
SEMADDENSG00000110514.14chr11+473482884734835847346021473461284735020847350255-0.371000.000000.00000excludedK562SF3B4
SEMADDENSG00000110514.14chr11+473079834730808547307001473071414731094147311044-0.082000.000000.00041excludedK562AKAP8L
SEMADDENSG00000110514.14chr11+473482884734835847346021473461284735020847350255-0.237000.000020.00160excludedK562AKAP8L
SEMADDENSG00000110514.14chr11+4729537747295527472912434729145747296113472964560.139000.000070.01187includedHepG2DDX59
SEMADDENSG00000110514.14chr11+4731051847310578473079834730808547310941473110440.110000.001980.09509includedHepG2AKAP1
SEMADDENSG00000110514.14chr11+4731726847317316473170464731713047317447473176060.120000.000830.01048includedK562AQR
SEMADDENSG00000110514.14chr11+473079834730808547306821473071414731094147311044-0.069000.006390.05695excludedK562AQR
SEMADDENSG00000110514.14chr11+473079834730808547307001473071414731094147311044-0.121000.000000.00000excludedK562PUS1
SEMADDENSG00000110514.14chr11+473482884734835847346021473461284735020847350255-0.266000.000000.00003excludedK562PUS1
SEMADDENSG00000110514.14chr11+473482884734835847346021473461284735020847350255-0.262000.000240.04219excludedHepG2HNRNPA1
SEMADDENSG00000110514.14chr11+4733053047330593473301414733025047330831473309520.210000.000000.00000includedK562U2AF1
SEMADDENSG00000110514.14chr11+4731409347314147473121604731236747315433473155340.090000.000290.04687includedK562HNRNPM
SEMADDENSG00000110514.14chr11+473154334731553447312160473123674731704647317130-0.136000.000250.03721excludedHepG2SSB
SEMADDENSG00000110514.14chr11+4734646847346583473460214734612847348288473483580.177000.000000.00003includedK562TARDBP
SEMADDENSG00000110514.14chr11+472953774729552747291698472917974729611347296456-0.324000.000000.00045excludedK562HNRNPU
SEMADDENSG00000110514.14chr11+473079834730808547307001473071414731094147311044-0.056000.000210.00803excludedK562RBM15
SEMADDENSG00000110514.14chr11+473079834730808547307001473071414731094147311044-0.065000.000070.00341excludedK562AGGF1
SEMADDENSG00000110514.14chr11+473482884734835847346021473461284735020847350255-0.152000.000560.02565excludedK562SF3B1
A3SSMADDENSG00000110514.14chr11+4730390647304146473039314730414647303125473033040.052000.017590.08548longerK562AQR
A5SSMADDENSG00000110514.14chr11+4730649147306745473064914730661647307001473071410.391000.002190.07056longerHepG2U2AF2
A5SSMADDENSG00000110514.14chr11+4730649147306745473064914730661647307001473071410.169000.001030.08163longerK562AKAP8L
MXEMADDENSG00000110514.14chr11+47307001473071414730798347308085473064914730674547310941473110440.141000.002320.058901includedK562RBM15
MXEMADDENSG00000110514.14chr11+47307028473071414730798347308085473064914730674547310941473110440.123000.000000.000041includedK562PUS1
MXEMADDENSG00000110514.14chr11+47307028473071414730798347308085473064914730674547310941473110440.077000.001240.042281includedK562AGGF1
MXEMADDENSG00000110514.14chr11+47307028473071414730798347308085473064914730674547310941473110440.106000.000870.008061includedK562AQR
MXEMADDENSG00000110514.14chr11+47307028473071414730798347308085473064914730674547310941473110440.077000.003060.078221includedHepG2SF3A3
MXEMADDENSG00000110514.14chr11+4730700147307141473079834730808547306491473067454731094147311044-0.170000.005530.099892includedHepG2XRN2
MXEMADDENSG00000110514.14chr11+47304363473045204730572847305832473039314730416747305925473061160.119000.002500.017521includedHepG2U2AF2
MXEMADDENSG00000110514.14chr11+47307028473071414730798347308085473064914730674547310941473110440.148000.004130.065581includedK562PRPF8

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for MADD is not avaliable on ENCORE database.