GCLC

General Information

Gene Name       : GCLC
Gene ID             : ENSG00000001084.12
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: GCLC)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878GCLCENSG00000001084.1228.6316.0922.36ENCSR000AEF
HepG2GCLCENSG00000001084.1261.4275.8968.66ENCSR985KAT
K562GCLCENSG00000001084.129.7713.4311.60ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for GCLC is not avaliable on ENCORE database.



Proteins bound to RNA
  • GCLC RNA is bound by 17 proteins.  







eCLIP assay for GCLC is not avaliable on ENCORE database.





17 proteins are bound to GCLC RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr65338087253380932-3'-UTR,CDS,intron-Distal,intron-Proximal5.6592517.17028HepG2PRPF8
chr65336237153362480-3'-UTR,intron-Distal4.579359.25286K562PUM2
chr65336324753363326-3'-UTR,intron-Distal4.8496020.03557K562PUM2
chr65337898353379097-3'-UTR,CDS,intron-Distal,intron-Proximal4.6653010.24470HepG2BCLAF1
chr65336345853363520-3'-UTR,intron-Distal,intron-Proximal7.0460313.61817K562PUM2
chr65336336453363415-3'-UTR,intron-Distal4.816316.49450K562PUM2
chr65337002553370074-3'-UTR,intron-Distal,intron-Proximal,polyA_site4.762775.51162HepG2U2AF2
chr65337335253373416-3'-UTR,CDS,intron-Distal,intron-Proximal3.769266.95612HepG2PRPF8
chr65337895653379054-3'-UTR,CDS,intron-Distal,intron-Proximal4.8808513.78100HepG2PRPF8
chr65337401053374064-3'-UTR,CDS,intron-Distal,intron-Proximal3.306795.40232HepG2U2AF2
chr65337007453370121-3'-UTR,CDS,intron-Distal,intron-Proximal3.610344.21358HepG2U2AF2
chr65340963353409691-5'-UTR,intron-Distal4.067498.75653HepG2DDX3X
chr65340959553409633-5'-UTR,intron-Distal4.823976.05264HepG2DDX3X
chr65340939353409450-5'-UTR,CDS,intron-Distal,intron-Proximal3.055505.26725HepG2DDX3X
chr65340948253409518-5'-UTR,intron-Distal,intron-Proximal4.049755.48791HepG2DDX3X
chr65340969153409794-5'-UTR,intron-Distal3.7568215.86410HepG2DDX3X
chr65340951853409595-5'-UTR,intron-Distal5.2157511.72256HepG2DDX3X
chr65336356253363665-CDS,intron-Distal,intron-Proximal4.422597.53358HepG2BCLAF1
chr65336369753363755-CDS,intron-Distal3.171633.94979HepG2BCLAF1
chr65337018653370265-CDS,intron-Distal,intron-Proximal3.238725.40132HepG2BCLAF1
chr65337228153372365-CDS,intron-Distal3.783793.12746HepG2GRWD1
chr65336485253364922-CDS,intron-Distal,intron-Proximal3.301816.47196HepG2BCLAF1
chr65336373053363789-CDS,intron-Distal3.883485.55825HepG2U2AF2
chr65336508453365178-CDS,intron-Distal,intron-Proximal4.888645.27173HepG2PRPF8
chr65336499253365084-CDS,intron-Distal,intron-Proximal4.648515.93128HepG2PRPF8
chr65337228553372377-CDS,intron-Distal3.206116.80151HepG2BCLAF1
chr65338566753385750-CDS,intron-Distal3.460145.14253HepG2GRWD1
chr65336485453364966-CDS,intron-Distal,intron-Proximal3.318435.30095HepG2PPIG
chr65336492253364963-CDS,intron-Distal,intron-Proximal4.698864.78529HepG2BCLAF1
chr65338344053383467-intron-Distal4.452255.01126K562TROVE2
chr65338031053380366-intron-Distal4.127123.40087HepG2RBFOX2
chr65340025853400318-intron-Distal4.192898.37624HepG2HNRNPC
chr65347576353475842-intron-Distal3.867803.41442HepG2HNRNPK
chr65339994853400018-intron-Distal3.155684.07077HepG2HNRNPC
chr65340445953404576-intron-Distal3.3027010.44216HepG2HNRNPM
chr65338135453381406-intron-Distal3.952693.18512HepG2HNRNPU
chr65337406853374124-intron-Distal,intron-Proximal4.525045.31973HepG2SF3B4
chr65339768753397742-intron-Distal3.998923.34098HepG2HNRNPM
chr65337488053374946-intron-Distal3.094053.14359HepG2HNRNPK
chr65337201753372110-intron-Distal3.586939.36850HepG2U2AF2
chr65337948753379578-intron-Distal3.907973.43967HepG2TAF15
chr65339154953391600-intron-Distal3.047063.70918HepG2HNRNPC
chr65337411153374202-intron-Distal,intron-Proximal3.195493.78824HepG2KHSRP
chr65336515053365161-intron-Distal,intron-Proximal3.520916.82255HepG2U2AF2
chr65339420853394264-intron-Distal4.272663.86368HepG2HNRNPM
chr65337477753374834-intron-Distal3.992843.74583HepG2PTBP1
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for GCLC is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for GCLC is not available on ENCORE database.

  • 92 RBPs can affect the levels of GCLC.  








The Knockdown/knockout RNA-Seq assay for GCLC is not available on ENCORE database.





92 RBPs can affect the gene expression of GCLC :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
GCLCENSG00000001084.62726.880501849.262700.560205.084104.39010HepG2AKAP1
GCLCENSG00000001084.62441.779401984.973200.298703.964003.16960HepG2AUH
GCLCENSG00000001084.61459.320401013.941000.525204.564003.43540HepG2BCLAF1
GCLCENSG00000001084.63043.773701361.640201.1604028.6600027.07660HepG2BOP1
GCLCENSG00000001084.61755.924301222.686900.522107.222806.05420HepG2CALR
GCLCENSG00000001084.61635.92940827.450100.983307.817004.57780HepG2CDC40
GCLCENSG00000001084.62040.068901453.734900.488804.709703.71570HepG2CIRBP
GCLCENSG00000001084.61394.933901188.618200.230802.581801.93490HepG2CKAP4
GCLCENSG00000001084.61168.287701751.44270-0.584103.534902.66420HepG2CNOT7
GCLCENSG00000001084.62565.253901633.659200.6509015.5527014.27270HepG2CELF1
GCLCENSG00000001084.61529.302801756.73360-0.200002.459901.75520HepG2DAZAP1
GCLCENSG00000001084.61317.671101099.554900.261003.013802.14610HepG2DDX19B
GCLCENSG00000001084.61256.32740999.815300.329402.716701.81320HepG2DDX24
GCLCENSG00000001084.62890.735701956.091000.563407.418205.40410HepG2DDX47
GCLCENSG00000001084.62245.119701419.554500.661303.897802.74780HepG2DDX59
GCLCENSG00000001084.63370.724301521.585101.1474019.0874017.65920HepG2DDX6
GCLCENSG00000001084.61345.917201137.454300.242702.338701.70760HepG2DKC1
GCLCENSG00000001084.61613.56980880.763600.8733012.4093010.64820HepG2EIF3D
GCLCENSG00000001084.63160.607601574.012701.0057011.9760010.59580HepG2EIF4B
GCLCENSG00000001084.62521.393901732.997300.5409011.5880010.10940HepG2EIF4G1
GCLCENSG00000001084.62987.625302279.050400.390507.376706.47470HepG2ETF1
GCLCENSG00000001084.61505.519901161.747600.373903.590702.63890HepG2EWSR1
GCLCENSG00000001084.61527.87820986.964800.630408.358207.02930HepG2FUBP3
GCLCENSG00000001084.62040.513001513.153100.431303.019402.32560HepG2G3BP1
GCLCENSG00000001084.6825.687701067.86790-0.371102.218301.31150HepG2GNB2L1
GCLCENSG00000001084.61611.020901135.047500.505107.716206.18640HepG2HDGF
GCLCENSG00000001084.6776.668701044.73730-0.427803.748403.01290HepG2HNRNPA1
GCLCENSG00000001084.61343.962201614.41670-0.264502.437001.55190HepG2HNRNPA2B1
GCLCENSG00000001084.61309.282501600.29510-0.289604.266803.44270HepG2HNRNPL
GCLCENSG00000001084.62551.867701541.334300.727307.406005.43770HepG2HSPD1
GCLCENSG00000001084.62695.524201538.142900.8093011.6999010.41550HepG2IGF2BP2
GCLCENSG00000001084.61011.837101179.16440-0.220802.137401.48370HepG2ILF2
GCLCENSG00000001084.61154.621801547.00460-0.422102.477801.53780HepG2KHSRP
GCLCENSG00000001084.62343.004801460.515400.681805.780503.71890HepG2NKRF
GCLCENSG00000001084.61346.903101741.96550-0.371104.550503.57330HepG2NOL12
GCLCENSG00000001084.613289.145801600.948203.0531042.3294039.28990HepG2PABPC1
GCLCENSG00000001084.62142.475901462.414200.5508012.1023010.97550HepG2PCBP1
GCLCENSG00000001084.61752.764201173.811600.578303.816202.60310HepG2PCBP2
GCLCENSG00000001084.6838.122901029.61810-0.296902.633501.91370HepG2PPIL4
GCLCENSG00000001084.61010.503801662.81720-0.7186011.2147010.12280HepG2PUF60
GCLCENSG00000001084.62840.153701765.105400.6861026.2718024.82170HepG2PUM1
GCLCENSG00000001084.62181.446901763.846200.306503.040002.33620HepG2PUM2
GCLCENSG00000001084.62022.743001210.974800.7400022.1547020.71800HepG2PUS1
GCLCENSG00000001084.63783.253101132.774201.7397023.4696021.62050HepG2RAVER1
GCLCENSG00000001084.62297.076301599.264800.522308.278206.90000HepG2RBM15
GCLCENSG00000001084.62625.972501904.857000.463108.162907.38210HepG2RBM22
GCLCENSG00000001084.62614.977101462.636000.8381017.5450015.94790HepG2RBM25
GCLCENSG00000001084.6651.64140857.00740-0.395203.042102.40140HepG2RPS19
GCLCENSG00000001084.61139.266201759.11030-0.626704.910703.84200HepG2RPS3A
GCLCENSG00000001084.61581.15510875.570000.8526010.214108.84220HepG2RRP9
GCLCENSG00000001084.62468.598601459.014900.758606.838305.74470HepG2SF3A3
GCLCENSG00000001084.65267.940401338.639701.9764077.8200074.98510HepG2SF3B1
GCLCENSG00000001084.62467.352601549.259300.6713017.9240016.62120HepG2SF3B4
GCLCENSG00000001084.61359.530801594.28300-0.229802.757802.05730HepG2SLBP
GCLCENSG00000001084.61608.261201154.899700.477603.024002.01900HepG2SMNDC1
GCLCENSG00000001084.66368.207402151.452801.56550139.59630137.43010HepG2SRFBP1
GCLCENSG00000001084.610459.748001315.597002.9910068.9555066.96600HepG2SRSF9
GCLCENSG00000001084.62457.764701535.397600.678607.334005.37990HepG2SSRP1
GCLCENSG00000001084.61843.295701058.599500.800006.650804.82930HepG2SUB1
GCLCENSG00000001084.62788.897601554.703300.843009.240206.88000HepG2SUGP2
GCLCENSG00000001084.61429.38660950.945700.587908.206806.65190HepG2SUPT6H
GCLCENSG00000001084.61607.949101142.088200.493404.078403.28080HepG2SUPV3L1
GCLCENSG00000001084.62127.097401453.520300.549209.933508.97590HepG2TAF15
GCLCENSG00000001084.61416.15530765.521500.8874011.402009.65660HepG2TFIP11
GCLCENSG00000001084.6632.621701121.75060-0.8263014.1571013.17930HepG2TIAL1
GCLCENSG00000001084.62117.066701204.549700.8135010.569009.32190HepG2U2AF1
GCLCENSG00000001084.63315.611501249.232901.4081082.9660080.45520HepG2UTP3
GCLCENSG00000001084.6705.117101124.25960-0.673006.227905.15460HepG2XRN2
GCLCENSG00000001084.62252.590401423.068300.6625016.9821015.91340HepG2ZNF622
GCLCENSG00000001084.6925.47570748.776800.305602.930102.34770K562AGGF1
GCLCENSG00000001084.6892.83430641.848600.476103.725003.06420K562AQR
GCLCENSG00000001084.6505.69290360.893900.486602.810401.93040K562BOP1
GCLCENSG00000001084.61354.92940951.154800.510405.782104.37260K562CELF1
GCLCENSG00000001084.61017.52020838.358100.279302.574701.73440K562DKC1
GCLCENSG00000001084.61198.72210773.482700.632009.525607.82020K562EIF4G2
GCLCENSG00000001084.6615.72190437.043000.494402.656501.96720K562G3BP2
GCLCENSG00000001084.6564.97140399.393200.500304.288602.87530K562GLRX3
GCLCENSG00000001084.6530.62120381.134400.477303.505802.29000K562HNRNPA1
GCLCENSG00000001084.6192.47940340.12950-0.821405.788304.95580K562HNRNPC
GCLCENSG00000001084.6652.24340422.076400.627806.834505.42610K562HNRNPU
GCLCENSG00000001084.6250.49090158.922600.656303.209201.59420K562ILF3
GCLCENSG00000001084.61069.92590826.835500.371703.340602.42470K562KIF1C
GCLCENSG00000001084.6716.52780434.552100.721402.861201.84890K562PABPN1
GCLCENSG00000001084.6588.10240372.130900.660204.729803.64450K562PCBP3
GCLCENSG00000001084.6396.46430285.443600.473902.902902.08120K562POLR2G
GCLCENSG00000001084.6478.27760320.271900.578503.622102.76310K562PRPF8
GCLCENSG00000001084.6231.72760474.38540-1.0336012.3875011.03330K562PTBP1
GCLCENSG00000001084.61141.08030843.914900.435103.334502.44010K562PUF60
GCLCENSG00000001084.61241.16490897.729000.467204.880503.43170K562PUM1
GCLCENSG00000001084.6187.21700278.31270-0.572003.138102.07540K562RCC2
GCLCENSG00000001084.6327.35640478.72320-0.548303.732902.44220K562NELFE
GCLCENSG00000001084.6316.04250444.91440-0.493402.452401.51550K562RPS3
GCLCENSG00000001084.6476.93410327.460900.542402.657401.35590K562RRP9
GCLCENSG00000001084.6847.96900456.437700.893503.894202.34490K562SNRNP200
GCLCENSG00000001084.6493.13270367.819600.422903.073901.71200K562SSB
GCLCENSG00000001084.6928.64220545.871700.766503.057101.53300K562SUPT6H
GCLCENSG00000001084.6417.40180286.298400.543803.620802.68240K562SYNCRIP
GCLCENSG00000001084.6333.91250470.67710-0.495303.097102.34730K562TARDBP
GCLCENSG00000001084.6575.48490437.479200.395502.799401.99100K562U2AF2
GCLCENSG00000001084.6948.86400537.049600.821003.475401.62870K562YTHDC2
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for GCLC is not available on ENCORE database.





4 RBPs can affect the splicing of GCLC :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEGCLCENSG00000001084.6chr6-533706005337069353370189533702945337171053371712-0.229000.000030.00083excludedK562PUS1
SEGCLCENSG00000001084.6chr6-533809065338102053379236533792955338557553385758-0.088000.000140.00947excludedHepG2SF3B4
SEGCLCENSG00000001084.6chr6-533809065338102053379236533792955338557553385758-0.131000.001200.03919excludedK562UTP18
A3SSGCLCENSG00000001084.6chr6-5337060053370756533706005337069353371710533718230.075000.014270.07168longerK562AQR
A3SSGCLCENSG00000001084.6chr6-5338090653381038533809065338102053385575533857860.136000.007510.04124longerK562AQR
A3SSGCLCENSG00000001084.6chr6-5337171053371877533717105337182353372277533724160.104000.000090.00080longerK562AQR

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for GCLC is not avaliable on ENCORE database.