MFN1

General Information

Gene Name       : MFN1
Gene ID             : ENSG00000171109.18
Essential Gene : No

Functions

Localization

Domains (AlphaFold: MFN1)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878MFN1ENSG00000171109.1833.4924.4228.96ENCSR000AEF
HepG2MFN1ENSG00000171109.1813.6721.7717.72ENCSR985KAT
K562MFN1ENSG00000171109.1814.0015.1814.59ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for MFN1 is not avaliable on ENCORE database.



Proteins bound to RNA
  • MFN1 RNA is bound by 16 proteins.  







eCLIP assay for MFN1 is not avaliable on ENCORE database.





16 proteins are bound to MFN1 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr3179096138179096204+3'-UTR,CDS,intron-Distal4.998596.04243HepG2BCLAF1
chr3179103346179103423+3'-UTR,CDS,intron-Proximal3.135666.24870K562U2AF2
chr3179103344179103416+3'-UTR,CDS,intron-Proximal3.079373.75327HepG2U2AF2
chr3179096385179096437+3'-UTR,CDS,intron-Distal5.105656.58593HepG2BCLAF1
chr3179107812179107903+3'-UTR,CDS3.147216.33024HepG2BCLAF1
chr3179110806179110900+3'-UTR6.549308.59158K562PUM2
chr3179109793179109869+3'-UTR,CDS5.8876912.09921HepG2BCLAF1
chr3179104280179104324+3'-UTR,CDS3.698864.09885HepG2BCLAF1
chr3179065803179065908+5'-UTR,intron-Distal4.864009.00450K562AKAP8L
chr3179065577179065598+5'-UTR3.202103.02345K562ZNF622
chr3179065815179065914+5'-UTR,intron-Distal,intron-Proximal3.950313.04224HepG2SUGP2
chr3179082137179082192+CDS3.763856.06436HepG2BCLAF1
chr3179085223179085315+CDS,intron-Proximal4.498564.94878HepG2GRWD1
chr3179069687179069742+CDS,intron-Proximal4.406388.41475HepG2BCLAF1
chr3179080228179080269+CDS3.982175.94293HepG2BCLAF1
chr3179076670179076781+CDS3.459489.67260HepG2BCLAF1
chr3179092990179093042+CDS,intron-Proximal3.049933.05961HepG2U2AF2
chr3179066712179066749+CDS3.384185.15500HepG2BCLAF1
chr3179069759179069825+CDS,intron-Proximal4.3214111.99763HepG2BCLAF1
chr3179092940179093017+CDS,intron-Proximal3.290013.53952HepG2KHSRP
chr3179085224179085305+CDS,intron-Proximal3.580347.58656HepG2BCLAF1
chr3179085884179085899+CDS,intron-Proximal3.908084.58287K562PRPF8
chr3179076746179076849+CDS,intron-Proximal4.073683.31283K562PRPF8
chr3179094856179094955+CDS,intron-Distal5.9374613.02740HepG2BCLAF1
chr3179082889179082948+CDS,intron-Proximal3.473014.51027K562BUD13
chr3179085228179085326+CDS3.707426.55026K562ZNF622
chr3179085324179085359+CDS4.570615.03746HepG2BCLAF1
chr3179076617179076669+CDS,intron-Proximal3.612013.02321K562U2AF2
chr3179076627179076670+CDS,intron-Proximal3.831597.23562HepG2BCLAF1
chr3179069650179069707+CDS,intron-Proximal5.265366.90654K562SF3B4
chr3179069915179069995+intron-Distal,intron-Proximal4.073683.31283K562PRPF8
chr3179065599179065723+intron-Distal,intron-Proximal5.250885.96317HepG2EFTUD2
chr3179085904179085996+intron-Distal,intron-Proximal3.097663.37074K562TIA1
chr3179090473179090542+intron-Distal3.503845.25527HepG2U2AF2
chr3179088199179088268+intron-Distal3.258734.41834HepG2HNRNPC
chr3179093282179093366+intron-Distal3.006953.42827HepG2KHSRP
chr3179088036179088141+intron-Distal4.101683.98095HepG2HNRNPL
chr3179089646179089724+intron-Distal4.567878.75974K562KHSRP
chr3179088047179088130+intron-Distal3.935203.37631K562HNRNPL
chr3179089572179089728+intron-Distal3.439498.24193HepG2KHSRP
chr3179065639179065770+intron-Distal,intron-Proximal4.946645.30668HepG2RBFOX2
chr3179085957179086053+intron-Distal,intron-Proximal3.562578.05393HepG2U2AF2
chr3179086135179086210+intron-Distal4.304198.11138K562KHSRP
chr3179088195179088282+intron-Distal3.855513.98534K562HNRNPC
chr3179085899179085935+intron-Proximal5.098686.45599K562PRPF8
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for MFN1 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for MFN1 is not available on ENCORE database.

  • 77 RBPs can affect the levels of MFN1.  








The Knockdown/knockout RNA-Seq assay for MFN1 is not available on ENCORE database.





77 RBPs can affect the gene expression of MFN1 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
MFN1ENSG00000171109.14399.69080843.13260-1.076909.058706.19450HepG2AARS
MFN1ENSG00000171109.141083.84740879.630500.301103.283302.63020HepG2ACO1
MFN1ENSG00000171109.14494.92330740.96010-0.582204.858803.58820HepG2ADAR
MFN1ENSG00000171109.141521.33140983.781700.628805.506904.78680HepG2AKAP1
MFN1ENSG00000171109.14469.66920814.04650-0.793504.176303.21990HepG2ASCC1
MFN1ENSG00000171109.14494.76980747.49940-0.595304.173003.08960HepG2BCLAF1
MFN1ENSG00000171109.14419.81780711.55150-0.761207.258606.18740HepG2CPSF6
MFN1ENSG00000171109.14385.40680531.40300-0.463402.738901.66740HepG2CSTF2
MFN1ENSG00000171109.14465.06910640.77260-0.462402.846401.43600HepG2DDX28
MFN1ENSG00000171109.141270.32000942.495200.430502.251401.68190HepG2DDX3X
MFN1ENSG00000171109.14539.57970734.13860-0.444203.187102.10880HepG2DDX5
MFN1ENSG00000171109.14632.51060841.58360-0.412004.200503.40020HepG2DKC1
MFN1ENSG00000171109.14579.55960739.47720-0.351503.475802.75930HepG2DNAJC2
MFN1ENSG00000171109.14834.88820553.959200.591705.060503.86490HepG2EIF3D
MFN1ENSG00000171109.14829.553401123.84940-0.438003.758802.81880HepG2EIF4G2
MFN1ENSG00000171109.14570.66470859.60960-0.591006.190804.94150HepG2EWSR1
MFN1ENSG00000171109.141134.08480819.253700.469002.706401.94600HepG2FIP1L1
MFN1ENSG00000171109.14313.84900806.57840-1.3617017.9869016.50000HepG2GPKOW
MFN1ENSG00000171109.141254.72470835.647100.586303.045901.58930HepG2HLTF
MFN1ENSG00000171109.14788.252301092.91480-0.471506.477005.14880HepG2HNRNPA2B1
MFN1ENSG00000171109.14572.42740837.87290-0.549604.800903.90520HepG2HNRNPC
MFN1ENSG00000171109.14881.688801069.93680-0.279202.517801.83260HepG2HNRNPF
MFN1ENSG00000171109.14818.124601083.38900-0.405206.019605.05750HepG2HNRNPL
MFN1ENSG00000171109.14754.31210565.291200.416103.272302.24660HepG2HNRNPM
MFN1ENSG00000171109.14576.51950832.33540-0.529806.978706.05230HepG2HNRNPU
MFN1ENSG00000171109.14840.318001053.58580-0.326302.601901.89990HepG2IGF2BP1
MFN1ENSG00000171109.141052.85970818.346700.363402.168301.56240HepG2IGF2BP2
MFN1ENSG00000171109.14714.69440850.20760-0.250502.303701.62740HepG2ILF2
MFN1ENSG00000171109.14564.42130804.13000-0.510707.050905.47420HepG2KIF1C
MFN1ENSG00000171109.14384.43050872.81270-1.182906.939305.97320HepG2MATR3
MFN1ENSG00000171109.141014.68940663.116000.613606.936105.71300HepG2MSI2
MFN1ENSG00000171109.141311.63350893.420600.553904.784903.96450HepG2NCBP2
MFN1ENSG00000171109.14598.40810823.90270-0.461305.194904.08150HepG2PARN
MFN1ENSG00000171109.14555.55990742.38130-0.418203.923203.06120HepG2PPIL4
MFN1ENSG00000171109.14373.18200679.22760-0.8640013.2793011.77640HepG2PRPF4
MFN1ENSG00000171109.141048.55070796.015300.397404.366903.71340HepG2PTBP1
MFN1ENSG00000171109.14677.717901125.68790-0.7321010.005008.96900HepG2PUF60
MFN1ENSG00000171109.14698.42100895.96960-0.359403.946603.23580HepG2PUS1
MFN1ENSG00000171109.141224.41630862.229000.505905.074904.26830HepG2QKI
MFN1ENSG00000171109.141765.69420796.864901.147707.019605.92390HepG2RAVER1
MFN1ENSG00000171109.141106.50320782.481100.499804.938504.06140HepG2RBM25
MFN1ENSG00000171109.14689.36490952.31990-0.466202.761401.77060HepG2RBM27
MFN1ENSG00000171109.14795.298701040.06600-0.387102.009601.32810HepG2RPS3A
MFN1ENSG00000171109.141083.05820645.501800.746507.234006.03350HepG2RRP9
MFN1ENSG00000171109.14574.84300741.24710-0.366803.603302.88530HepG2SAFB2
MFN1ENSG00000171109.14936.477701079.26270-0.204701.964201.35460HepG2SLBP
MFN1ENSG00000171109.141357.71490847.721800.679403.540002.65150HepG2SNRNP70
MFN1ENSG00000171109.141757.853001511.698100.217502.339901.86640HepG2SRFBP1
MFN1ENSG00000171109.141213.87250865.107100.488605.541104.93000HepG2SRSF1
MFN1ENSG00000171109.14795.546701051.16540-0.402004.708503.83720HepG2SRSF7
MFN1ENSG00000171109.14970.35780703.773800.463305.251904.53430HepG2SRSF9
MFN1ENSG00000171109.141107.407801312.47760-0.245102.526502.03120HepG2SSB
MFN1ENSG00000171109.141047.51940714.518100.551805.396804.24090HepG2TIA1
MFN1ENSG00000171109.14513.95290808.86890-0.654307.940407.17310HepG2TIAL1
MFN1ENSG00000171109.14596.75900815.99270-0.451404.026303.37130HepG2TRIM56
MFN1ENSG00000171109.14400.97850700.85570-0.805608.040506.97050HepG2U2AF1
MFN1ENSG00000171109.141134.69450783.476700.534203.163201.80680HepG2XRCC5
MFN1ENSG00000171109.14563.25040828.82290-0.557303.890603.03960HepG2XRN2
MFN1ENSG00000171109.141100.49430801.543900.457207.333106.55280HepG2ZNF622
MFN1ENSG00000171109.14487.37240791.91250-0.700306.965605.04060K562AARS
MFN1ENSG00000171109.141108.500201593.25470-0.523409.075808.12420K562AGGF1
MFN1ENSG00000171109.141403.824101827.25440-0.380303.164402.54470K562AQR
MFN1ENSG00000171109.14817.655701058.35750-0.372304.078702.89520K562BCLAF1
MFN1ENSG00000171109.14594.53650802.92160-0.433503.561002.34080K562CSTF2
MFN1ENSG00000171109.141719.887201405.324100.291303.462802.74490K562DDX47
MFN1ENSG00000171109.14807.878101259.47460-0.640606.392805.36560K562EIF2S2
MFN1ENSG00000171109.141295.36950866.716500.579604.975603.54030K562EIF3D
MFN1ENSG00000171109.14749.96200957.51150-0.352502.590601.79640K562EIF4A3
MFN1ENSG00000171109.141615.053901089.729300.567504.253003.33310K562G3BP2
MFN1ENSG00000171109.14531.45230730.67640-0.459303.498902.60980K562GPKOW
MFN1ENSG00000171109.141203.553801678.55790-0.479902.905102.13170K562GRSF1
MFN1ENSG00000171109.14670.11090866.42230-0.370702.731802.13860K562HNRNPC
MFN1ENSG00000171109.14582.16140773.75540-0.410502.955901.77450K562HNRNPF
MFN1ENSG00000171109.14577.75710772.66560-0.419403.352601.62230K562LSM11
MFN1ENSG00000171109.141104.420001477.09840-0.419503.789002.79640K562MAGOH
MFN1ENSG00000171109.14890.168201474.19010-0.7278010.035808.17200K562MATR3
MFN1ENSG00000171109.14414.04940713.21240-0.784508.761607.13880K562METAP2
MFN1ENSG00000171109.141218.81960956.137700.350103.204801.87570K562NCBP2
MFN1ENSG00000171109.143023.188302240.248500.432304.628002.66680K562NOL12
MFN1ENSG00000171109.14696.275601152.46900-0.727003.391002.26130K562PABPN1
MFN1ENSG00000171109.14541.73170776.84930-0.520103.735802.66350K562PSIP1
MFN1ENSG00000171109.141850.918802328.77430-0.331304.383303.16850K562PUM2
MFN1ENSG00000171109.141209.161601644.16090-0.443304.156503.51070K562PUS1
MFN1ENSG00000171109.141287.123601601.96320-0.315703.107002.48390K562RBM15
MFN1ENSG00000171109.14414.11040671.94350-0.698306.372504.63560K562SRFBP1
MFN1ENSG00000171109.141084.023401406.76250-0.376003.227202.46840K562SRSF1
MFN1ENSG00000171109.14576.08040747.19270-0.375202.157701.34080K562TIAL1
MFN1ENSG00000171109.14592.57460793.85430-0.421903.092402.08110K562TRIM56
MFN1ENSG00000171109.14922.471301205.62790-0.386204.802403.12010K562TROVE2
MFN1ENSG00000171109.14975.799901209.88180-0.310203.284402.50590K562UPF1
MFN1ENSG00000171109.141312.675001076.591800.285903.460102.52190K562WDR43
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for MFN1 is not available on ENCORE database.





13 RBPs can affect the splicing of MFN1 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEMFN1ENSG00000171109.14chr3+179107757179107926179104220179104417179109768179112719-0.083000.004440.04212excludedK562AQR
SEMFN1ENSG00000171109.14chr3+179096128179096602179095131179095236179103356179103509-0.093000.003960.06823excludedK562U2AF1
SEMFN1ENSG00000171109.14chr3+179096128179096602179095131179095236179103356179103509-0.135000.000180.00478excludedK562U2AF2
A3SSMFN1ENSG00000171109.14chr3+1790666011790667511790666321790667511790654791790655980.114000.000000.00001longerK562AQR
RIMFN1ENSG00000171109.14chr3+1790961281790966021790961281790962311790963721790966020.098000.001000.05195includedHepG2BCCIP
RIMFN1ENSG00000171109.14chr3+1790961281790966021790961281790962311790963721790966020.112000.004770.02968includedK562PUS1
RIMFN1ENSG00000171109.14chr3+1790961281790966021790961281790962311790963721790966020.082000.002950.03575includedHepG2PRPF8
RIMFN1ENSG00000171109.14chr3+1790961281790966021790961281790962311790963721790966020.099000.005650.05755includedK562AGGF1
RIMFN1ENSG00000171109.14chr3+1790961281790966021790961281790962311790963721790966020.100000.001090.08352includedHepG2DDX55
RIMFN1ENSG00000171109.14chr3+1790961281790966021790961281790962311790963721790966020.117000.011450.09479includedHepG2QKI
RIMFN1ENSG00000171109.14chr3+1790961281790966021790961281790962311790963721790966020.152000.000470.04246includedK562AARS
RIMFN1ENSG00000171109.14chr3+1790961281790966021790961281790962311790963721790966020.087000.004920.08016includedHepG2KHSRP
RIMFN1ENSG00000171109.14chr3+1790961281790966021790961281790962311790963721790966020.084000.000690.00931includedHepG2RBM22
RIMFN1ENSG00000171109.14chr3+1790961281790966021790961281790962311790963721790966020.084000.001310.06836includedHepG2SSB
MXEMFN1ENSG00000171109.14chr3+1791041761791044171791077571791079261791033121791035091791097681791127190.084000.000010.000091includedK562AQR

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for MFN1 is not avaliable on ENCORE database.