CUL2

General Information

Gene Name       : CUL2
Gene ID             : ENSG00000108094.14
Essential Gene : No

Functions

Localization

Domains (AlphaFold: CUL2)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878CUL2ENSG00000108094.1429.2023.9926.59ENCSR000AEF
HepG2CUL2ENSG00000108094.1414.5825.0719.82ENCSR985KAT
K562CUL2ENSG00000108094.1427.9131.1129.51ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for CUL2 is not avaliable on ENCORE database.



Proteins bound to RNA
  • CUL2 RNA is bound by 11 proteins.  







eCLIP assay for CUL2 is not avaliable on ENCORE database.





11 proteins are bound to CUL2 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr103531777035317826-3'-UTR,CDS,intron-Distal,intron-Proximal4.282464.11564K562U2AF2
chr103532209135322162-3'-UTR,CDS,intron-Distal,intron-Proximal3.891895.36555HepG2BCLAF1
chr103530520635305294-3'-UTR,CDS,intron-Distal4.014124.30417K562YBX3
chr103532799435328172-3'-UTR,CDS,intron-Distal,intron-Proximal3.271574.30679K562KHSRP
chr103529882635298908-3'-UTR,intron-Distal4.4169710.68247K562PABPC4
chr103529887835298918-3'-UTR,intron-Distal4.060244.66738K562KHDRBS1
chr103529908435299147-3'-UTR,intron-Distal,intron-Proximal3.088073.29348K562YBX3
chr103532410635324175-3'-UTR,CDS,intron-Distal3.730903.31827HepG2GRWD1
chr103531406135314110-3'-UTR,CDS,intron-Distal3.673844.17155HepG2BCLAF1
chr103534980035349843-5'-UTR,CDS,intron-Distal,intron-Proximal3.671884.24220K562ZNF622
chr103534336535343433-5'-UTR,CDS,intron-Distal4.636094.34038HepG2BCLAF1
chr103534980035349899-5'-UTR,CDS,intron-Distal,intron-Proximal3.003715.24703K562BUD13
chr103534981435349897-CDS,intron-Distal,intron-Proximal3.503487.21479K562UCHL5
chr103534980535349897-CDS,intron-Distal,intron-Proximal5.438449.78817HepG2BCLAF1
chr103535188735351918-CDS,intron-Distal,intron-Proximal4.570804.78571K562UCHL5
chr103536094035361020-intron-Distal4.397335.25869K562RBFOX2
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for CUL2 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for CUL2 is not available on ENCORE database.

  • 58 RBPs can affect the levels of CUL2.  








The Knockdown/knockout RNA-Seq assay for CUL2 is not available on ENCORE database.





58 RBPs can affect the gene expression of CUL2 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
CUL2ENSG00000108094.10572.47810685.37000-0.259701.959901.43160HepG2ACO1
CUL2ENSG00000108094.10421.10010649.80910-0.625904.124202.98380HepG2BCCIP
CUL2ENSG00000108094.10297.49550564.62180-0.924408.016506.58830HepG2BCLAF1
CUL2ENSG00000108094.10588.91560741.47580-0.332301.973501.46050HepG2BOP1
CUL2ENSG00000108094.10455.59220680.72720-0.579304.327503.48470HepG2CPSF6
CUL2ENSG00000108094.10494.64790817.07790-0.724105.856104.98740HepG2DDX6
CUL2ENSG00000108094.10379.39270539.16190-0.507005.285404.42870HepG2DNAJC2
CUL2ENSG00000108094.10544.30800785.64620-0.529503.551302.88360HepG2EIF2S1
CUL2ENSG00000108094.10609.34400812.60400-0.415302.481401.84950HepG2G3BP1
CUL2ENSG00000108094.10287.78520549.23900-0.932409.452908.36260HepG2HNRNPA1
CUL2ENSG00000108094.10436.05400610.90630-0.486403.314802.56130HepG2HNRNPC
CUL2ENSG00000108094.10649.70590822.53070-0.340302.017901.41510HepG2HNRNPK
CUL2ENSG00000108094.10637.58950878.15340-0.461806.136305.16730HepG2HNRNPL
CUL2ENSG00000108094.10377.90400736.43520-0.9625010.447109.31820HepG2HNRNPLL
CUL2ENSG00000108094.10420.91850606.86880-0.527805.496804.66450HepG2HNRNPU
CUL2ENSG00000108094.10629.06780955.94210-0.603707.636706.38730HepG2NOL12
CUL2ENSG00000108094.10497.38830652.96680-0.392602.183601.51660HepG2NSUN2
CUL2ENSG00000108094.10411.59410541.28210-0.395202.974902.21400HepG2PPIL4
CUL2ENSG00000108094.10438.13700547.15110-0.320602.269801.56210HepG2PRPF4
CUL2ENSG00000108094.10754.52780968.71770-0.360504.370803.66200HepG2PUM1
CUL2ENSG00000108094.10796.63030968.00150-0.281101.979201.40590HepG2PUM2
CUL2ENSG00000108094.101358.20750666.719101.026507.978606.81940HepG2RAVER1
CUL2ENSG00000108094.10635.60530785.07260-0.304702.271101.48520HepG2RBM15
CUL2ENSG00000108094.10494.694501034.80560-1.0647021.8861020.70930HepG2RBM22
CUL2ENSG00000108094.10371.56070540.45560-0.540605.457904.60600HepG2SAFB2
CUL2ENSG00000108094.101009.15160706.608200.514103.241602.51080HepG2SF3A3
CUL2ENSG00000108094.10674.68630875.01420-0.375104.073203.24560HepG2SLBP
CUL2ENSG00000108094.10517.28290630.28300-0.285002.256101.66580HepG2SMN1
CUL2ENSG00000108094.101298.55570869.801800.578009.805209.03790HepG2SRSF1
CUL2ENSG00000108094.10571.24620707.62160-0.308902.697502.15120HepG2SRSF9
CUL2ENSG00000108094.101278.108501014.791400.332704.079903.48300HepG2SSB
CUL2ENSG00000108094.10308.41510438.78480-0.508602.580601.38010HepG2STAU1
CUL2ENSG00000108094.10864.349601024.69280-0.245502.206001.63930HepG2SUCLG1
CUL2ENSG00000108094.10631.65290781.78460-0.307602.402901.87430HepG2TAF15
CUL2ENSG00000108094.10551.56890717.70920-0.379902.328201.65590HepG2TARDBP
CUL2ENSG00000108094.10521.13090718.38230-0.463104.044503.03880HepG2TIA1
CUL2ENSG00000108094.10431.82320589.76350-0.449703.518502.96830HepG2TIAL1
CUL2ENSG00000108094.10342.25720594.95290-0.7977010.989509.97700HepG2TRIM56
CUL2ENSG00000108094.10797.89010561.985000.505603.434402.73980HepG2U2AF1
CUL2ENSG00000108094.10570.09350689.19920-0.273702.284201.77300HepG2ZNF622
CUL2ENSG00000108094.101032.558101261.79760-0.289302.800901.48250K562BCCIP
CUL2ENSG00000108094.10918.421101219.41780-0.409005.569904.19330K562BCLAF1
CUL2ENSG00000108094.10316.87730529.19650-0.739903.819802.53970K562CCAR1
CUL2ENSG00000108094.101070.745401369.36440-0.354903.510602.16020K562CCDC124
CUL2ENSG00000108094.101451.724101829.23760-0.333504.015402.67100K562CPEB4
CUL2ENSG00000108094.10889.213401215.59340-0.451104.725403.70430K562CPSF6
CUL2ENSG00000108094.101312.456601596.90250-0.283002.370501.69620K562EIF2S2
CUL2ENSG00000108094.101434.087701075.599900.414905.446504.63700K562FXR1
CUL2ENSG00000108094.101469.186301105.572700.410102.433601.77690K562G3BP2
CUL2ENSG00000108094.10885.382901160.61150-0.390503.224302.36900K562GPKOW
CUL2ENSG00000108094.101585.469802128.22870-0.424703.259802.44180K562GRSF1
CUL2ENSG00000108094.10962.288601448.09930-0.589608.103806.34800K562HNRNPA1
CUL2ENSG00000108094.10561.38630972.72640-0.7930010.400109.30200K562HNRNPC
CUL2ENSG00000108094.101334.133101603.65510-0.265502.513801.66140K562HNRNPU
CUL2ENSG00000108094.10857.289801132.87830-0.402103.526602.53060K562METAP2
CUL2ENSG00000108094.10875.125401326.85520-0.6004011.166509.65970K562MTPAP
CUL2ENSG00000108094.101245.781501474.24170-0.242903.077902.29460K562NSUN2
CUL2ENSG00000108094.101713.114201026.887900.7382010.127208.68910K562PRPF8
CUL2ENSG00000108094.10546.93260872.14320-0.673206.702605.19090K562PSIP1
CUL2ENSG00000108094.102377.864103114.10980-0.389205.693704.30010K562PUM2
CUL2ENSG00000108094.10611.11150795.67940-0.380802.870401.86060K562RCC2
CUL2ENSG00000108094.10534.26360754.28670-0.497603.863802.58990K562SRFBP1
CUL2ENSG00000108094.101005.805301288.55240-0.357402.784801.73200K562SRSF5
CUL2ENSG00000108094.101295.482001679.42760-0.374502.728101.48780K562STAU1
CUL2ENSG00000108094.101143.81100874.824500.386703.737302.78340K562SYNCRIP
CUL2ENSG00000108094.101127.812601380.87470-0.292101.938901.33990K562TARDBP
CUL2ENSG00000108094.10968.837601332.00550-0.459305.060403.90140K562TIA1
CUL2ENSG00000108094.10592.35770838.86050-0.502003.632702.55640K562TIAL1
CUL2ENSG00000108094.10601.16000891.13810-0.567904.951603.59820K562TRIM56
CUL2ENSG00000108094.101048.999901563.17080-0.5755010.750109.45070K562UPF1
CUL2ENSG00000108094.102053.314402483.51410-0.274402.275301.50440K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for CUL2 is not available on ENCORE database.





11 RBPs can affect the splicing of CUL2 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SECUL2ENSG00000108094.10chr10-3537882335378929353601263536026735379106353792920.288000.001550.05175includedK562PRPF8
SECUL2ENSG00000108094.10chr10-3537882335378929353601263536026735379106353792920.328000.000190.07216includedK562XRN2
SECUL2ENSG00000108094.10chr10-3537882335378929353601263536026735379106353792920.307000.000340.04396includedK562FMR1
SECUL2ENSG00000108094.10chr10-3537882335378929353601263536026735379106353792920.796000.011190.09971includedHepG2U2AF2
SECUL2ENSG00000108094.10chr10-3537882335378929353601263536026735379106353792920.251000.001340.01565includedK562AQR
SECUL2ENSG00000108094.10chr10-353202273532034635318415353185683532041835320571-0.062000.000150.00241excludedK562AQR
SECUL2ENSG00000108094.10chr10-353336993533391235333493353336043533861035338693-0.063000.012080.09436excludedK562AQR
SECUL2ENSG00000108094.10chr10-3537882335378929353601263536026735379106353792920.345000.000660.05267includedK562SUPV3L1
SECUL2ENSG00000108094.10chr10-353788233537892935360126353602673537910635379292-0.348000.000590.04032excludedHepG2FTO
SECUL2ENSG00000108094.10chr10-3537882335378929353601263536026735379106353792920.307000.000180.01345includedK562EFTUD2
SECUL2ENSG00000108094.10chr10-3537882335378929353601263536026735379106353792920.525000.000000.00000includedK562HNRNPC
A3SSCUL2ENSG00000108094.10chr10-3529921935299462352992193529937035300775353009440.073000.000000.00000longerK562AQR
A3SSCUL2ENSG00000108094.10chr10-3532041835320602353204183532054735321362353214970.234000.000000.00000longerK562AQR
A5SSCUL2ENSG00000108094.10chr10-353791063537957035379357353795703536012635360267-0.270000.000120.01061shorterHepG2SRSF1
A5SSCUL2ENSG00000108094.10chr10-353791063537957035379357353795703536012635360267-0.220000.000010.00192shorterK562PRPF8
MXECUL2ENSG00000108094.10chr10-3530077535300892353026263530272835297478352993703530511935305322-0.156000.000030.002012includedK562HNRNPUL1

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for CUL2 is not avaliable on ENCORE database.