OPTN

General Information

Gene Name       : OPTN
Gene ID             : ENSG00000123240.16
Essential Gene : No

Functions

Localization

Domains (AlphaFold: OPTN)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878OPTNENSG00000123240.1617.7117.7317.72ENCSR000AEF
HepG2OPTNENSG00000123240.166.217.686.95ENCSR985KAT
K562OPTNENSG00000123240.163.733.573.65ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for OPTN is not avaliable on ENCORE database.



Proteins bound to RNA
  • OPTN RNA is bound by 7 proteins.  







eCLIP assay for OPTN is not avaliable on ENCORE database.





7 proteins are bound to OPTN RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr101315111913151188+3'-UTR,5'-UTR,CDS4.696784.04622HepG2GRWD1
chr101315227913152423+CDS,intron-Distal3.544103.26602K562PUM1
chr101315235913152421+CDS,intron-Distal3.387673.40321HepG2GRWD1
chr101316604313166102+CDS3.354736.33024HepG2BCLAF1
chr101316982513169898+CDS3.006533.90804HepG2GRWD1
chr101315235813152429+CDS,intron-Distal4.703955.10960K562ZNF622
chr101315445213154493+CDS,intron-Proximal4.302114.10264K562ZNF622
chr101315235513152418+CDS,intron-Distal4.617444.07690HepG2ZNF800
chr101316974713169828+CDS3.6101114.34206HepG2BCLAF1
chr101315235213152430+CDS,intron-Distal4.8056522.88455HepG2BCLAF1
chr101315449313154616+CDS4.168016.61895K562ZNF622
chr101315445313154554+CDS3.4315510.70004HepG2BCLAF1
chr101316742113167486+CDS4.4022712.53492HepG2BCLAF1
chr101316795013167968+CDS3.080344.61799HepG2BCLAF1
chr101315452813154604+CDS4.302383.38114HepG2GRWD1
chr101317406913174185+CDS3.794785.42720K562UCHL5
chr101316094713161037+CDS3.5876613.63205HepG2BCLAF1
chr101315230413152352+CDS,intron-Distal3.669588.66838HepG2BCLAF1
chr101316438413164473+CDS,intron-Proximal3.2374811.79442HepG2BCLAF1
chr101315236113152427+CDS,intron-Distal3.900563.88696K562GRWD1
chr101317409713174181+CDS3.6387110.10467HepG2BCLAF1
chr101315445213154577+CDS,intron-Proximal3.823494.12907HepG2FASTKD2
chr101316985413169904+CDS,intron-Proximal3.644986.20035HepG2BCLAF1
chr101315243013152477+CDS,intron-Distal,intron-Proximal4.039116.97808HepG2BCLAF1
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for OPTN is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for OPTN is not available on ENCORE database.

  • 172 RBPs can affect the levels of OPTN.  








The Knockdown/knockout RNA-Seq assay for OPTN is not available on ENCORE database.





172 RBPs can affect the gene expression of OPTN :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
OPTNENSG00000123240.121052.199201675.02010-0.670804.504103.32390HepG2ABCF1
OPTNENSG00000123240.12950.143201585.27730-0.7385019.4594018.16620HepG2ACO1
OPTNENSG00000123240.12448.49160700.03970-0.642405.574704.22790HepG2ADAR
OPTNENSG00000123240.121361.979702961.43930-1.1206017.6489016.42570HepG2AKAP1
OPTNENSG00000123240.121899.014401592.628200.253702.930702.14210HepG2AKAP8L
OPTNENSG00000123240.12739.24960449.136400.718804.906803.73940HepG2BCLAF1
OPTNENSG00000123240.121007.85970667.058400.595305.961905.12320HepG2BOP1
OPTNENSG00000123240.121801.136501254.465400.521705.830804.08930HepG2BUD13
OPTNENSG00000123240.121809.786401031.696500.8107016.0571014.47200HepG2CALR
OPTNENSG00000123240.121072.251201537.26490-0.519703.620802.49030HepG2CCAR1
OPTNENSG00000123240.121572.894302803.54030-0.833806.367503.41230HepG2CDC40
OPTNENSG00000123240.121108.552601584.81590-0.5156011.054109.90420HepG2CKAP4
OPTNENSG00000123240.121507.594502602.97620-0.787904.180703.23490HepG2CNOT7
OPTNENSG00000123240.121406.19880612.382101.1992021.7611020.06790HepG2CPSF6
OPTNENSG00000123240.121809.978001378.788500.392503.494502.25640HepG2CPSF7
OPTNENSG00000123240.12184.61320319.22330-0.790103.635102.41490HepG2CSTF2
OPTNENSG00000123240.122143.821301253.161800.7745021.0600019.62230HepG2CELF1
OPTNENSG00000123240.121625.523501347.243000.270804.151003.27180HepG2DAZAP1
OPTNENSG00000123240.12947.066101466.10060-0.6304014.9717013.37440HepG2DDX19B
OPTNENSG00000123240.12508.47240718.87490-0.499604.706303.21470HepG2DDX1
OPTNENSG00000123240.12821.96820475.531600.789405.191203.49150HepG2DDX27
OPTNENSG00000123240.122146.243202836.80540-0.402503.316002.63900HepG2DDX3X
OPTNENSG00000123240.12804.06590508.337200.661403.848802.95170HepG2DDX55
OPTNENSG00000123240.121816.35690695.409401.3850013.6582011.60460HepG2DDX59
OPTNENSG00000123240.121031.75920679.874500.601706.568305.10740HepG2DHX30
OPTNENSG00000123240.121250.102601516.65060-0.278803.048402.34150HepG2DKC1
OPTNENSG00000123240.121376.18800704.890100.9651023.2830021.45930HepG2DNAJC21
OPTNENSG00000123240.12766.602401104.04950-0.526304.420003.28120HepG2EEF2
OPTNENSG00000123240.12677.11720920.32060-0.442703.296202.08610HepG2EFTUD2
OPTNENSG00000123240.121239.50080894.994300.469702.701801.60980HepG2AGO1
OPTNENSG00000123240.123199.928102342.624500.449804.126603.41160HepG2EIF2S1
OPTNENSG00000123240.12585.32400917.63050-0.648704.835303.45410HepG2EIF3G
OPTNENSG00000123240.121057.448602588.84220-1.2917022.9519021.15250HepG2EIF4A3
OPTNENSG00000123240.121065.376102520.66460-1.2424016.8952015.29630HepG2EIF4B
OPTNENSG00000123240.122655.595001329.321900.9982038.8660036.52300HepG2EIF4G1
OPTNENSG00000123240.122427.341801273.372300.9306017.4001015.49940HepG2EIF4G2
OPTNENSG00000123240.121068.734601450.59030-0.440702.723201.64020HepG2ESF1
OPTNENSG00000123240.12879.721601548.99540-0.8162014.1336012.32880HepG2EWSR1
OPTNENSG00000123240.121116.64170801.063500.479105.330503.67560HepG2FAM120A
OPTNENSG00000123240.121564.43240925.871000.7567012.074309.97410HepG2FASTKD2
OPTNENSG00000123240.12708.01110423.065900.742805.514603.77600HepG2FKBP4
OPTNENSG00000123240.121260.93640613.460501.039405.353703.94700HepG2FTO
OPTNENSG00000123240.12536.780101160.75340-1.1127011.750109.67850HepG2FUS
OPTNENSG00000123240.121113.722402612.13370-1.2298024.6120022.78540HepG2FXR1
OPTNENSG00000123240.121607.148502423.08420-0.592306.009505.04570HepG2G3BP1
OPTNENSG00000123240.121831.912302572.48360-0.489804.866403.67370HepG2G3BP2
OPTNENSG00000123240.12408.23900797.93790-0.9669011.176809.45010HepG2GEMIN5
OPTNENSG00000123240.121481.88360694.144801.0940015.6887014.28180HepG2GPKOW
OPTNENSG00000123240.121532.335302409.94170-0.653303.559202.29500HepG2GRSF1
OPTNENSG00000123240.121132.83570711.643500.670607.783506.78290HepG2HNRNPA1
OPTNENSG00000123240.12565.50190791.58400-0.485203.760302.96170HepG2HNRNPC
OPTNENSG00000123240.121884.85650928.046501.0221015.9582014.42320HepG2HNRNPF
OPTNENSG00000123240.121661.342102453.71570-0.562606.820805.76180HepG2HNRNPK
OPTNENSG00000123240.121551.630901227.170400.338305.678004.74330HepG2HNRNPL
OPTNENSG00000123240.121877.80720662.438601.5031034.0511032.23450HepG2HNRNPLL
OPTNENSG00000123240.12651.493901166.52050-0.840407.653706.19370HepG2HNRNPM
OPTNENSG00000123240.122253.165203613.89770-0.681606.859204.96030HepG2HSPD1
OPTNENSG00000123240.121692.35190913.864600.8889018.7796017.08050HepG2IGF2BP1
OPTNENSG00000123240.123002.968002462.993400.285901.983001.40220HepG2IGF2BP2
OPTNENSG00000123240.121135.90530803.228000.499909.270608.00850HepG2ILF2
OPTNENSG00000123240.123428.161402537.937600.433702.608501.33520HepG2ILF3
OPTNENSG00000123240.12842.971801623.12830-0.9452010.424508.81520HepG2LARP4
OPTNENSG00000123240.12652.129602613.04610-2.0025056.5863053.86100HepG2MAGOH
OPTNENSG00000123240.121182.664902627.65470-1.1517019.1047017.56550HepG2MATR3
OPTNENSG00000123240.12848.862401368.20390-0.688706.883305.66420HepG2MSI2
OPTNENSG00000123240.121110.45250675.684300.716604.728103.44220HepG2MTPAP
OPTNENSG00000123240.121506.992002689.53740-0.8357011.4462010.20180HepG2NCBP2
OPTNENSG00000123240.121263.75650587.406101.1052017.3536015.67240HepG2NSUN2
OPTNENSG00000123240.124051.708302379.696400.767703.144002.19450HepG2PABPC1
OPTNENSG00000123240.123727.376102395.147400.637907.698606.51010HepG2PABPC4
OPTNENSG00000123240.12646.77530778.33630-0.267102.054501.31530HepG2PARN
OPTNENSG00000123240.121242.205702528.11310-1.0252029.1988027.58340HepG2PCBP1
OPTNENSG00000123240.122134.628501507.515900.501704.370302.21850HepG2PES1
OPTNENSG00000123240.121490.20840848.019800.813208.684405.90000HepG2PHF6
OPTNENSG00000123240.12472.68350741.14280-0.648907.366205.42850HepG2PKM
OPTNENSG00000123240.121015.71640701.358900.534205.896104.85080HepG2PPIL4
OPTNENSG00000123240.12751.868301155.18230-0.619603.930902.49060HepG2PRPF6
OPTNENSG00000123240.12931.05550391.925001.2482016.0086014.28700HepG2PRPF8
OPTNENSG00000123240.121385.995002572.57540-0.8923029.8519028.43370HepG2PTBP1
OPTNENSG00000123240.12947.805801275.32590-0.428203.464302.80740HepG2PUF60
OPTNENSG00000123240.12927.611101353.88400-0.545509.134908.18970HepG2PUM1
OPTNENSG00000123240.122070.705701352.852000.6140011.087609.79170HepG2PUM2
OPTNENSG00000123240.121369.235401614.69060-0.237902.773302.15670HepG2PUS1
OPTNENSG00000123240.121957.454901060.481700.884206.485105.43100HepG2RAVER1
OPTNENSG00000123240.123061.188302031.672200.5913011.229609.68380HepG2RBM15
OPTNENSG00000123240.122001.039801343.673700.574504.473003.85580HepG2RBM22
OPTNENSG00000123240.12684.409401065.37680-0.638405.691604.25230HepG2RBM27
OPTNENSG00000123240.12650.17610865.13040-0.412102.463001.46340HepG2RCC2
OPTNENSG00000123240.121004.659502862.92490-1.5108072.5563070.72120HepG2NELFE
OPTNENSG00000123240.121085.318602666.61510-1.2969041.3740039.55810HepG2RECQL
OPTNENSG00000123240.122948.52180999.678101.5604047.8435045.85250HepG2RPLP0
OPTNENSG00000123240.121587.421501041.589700.607803.980302.84880HepG2RPS10
OPTNENSG00000123240.12449.62040872.08670-0.9558014.1404012.89140HepG2RPS19
OPTNENSG00000123240.12719.93220982.60610-0.448803.107602.25930HepG2RPS2
OPTNENSG00000123240.121379.546402615.54800-0.922906.183204.99380HepG2RPS3A
OPTNENSG00000123240.121227.80720387.673801.6631027.0446025.08380HepG2RRP9
OPTNENSG00000123240.12914.37180700.272000.384804.514003.72470HepG2SAFB2
OPTNENSG00000123240.12714.825901877.62260-1.393205.616403.55550HepG2SF1
OPTNENSG00000123240.12488.888401702.04380-1.7997031.0581028.77020HepG2SF3A3
OPTNENSG00000123240.121103.57000655.661400.751108.873107.67820HepG2SF3B1
OPTNENSG00000123240.121274.387102678.15750-1.0714040.4627038.70950HepG2SF3B4
OPTNENSG00000123240.12923.896601821.02250-0.978902.848001.37310HepG2SFPQ
OPTNENSG00000123240.122182.648501222.981000.835609.287908.12230HepG2SLBP
OPTNENSG00000123240.121226.62430729.546200.749505.301804.20940HepG2SNRNP70
OPTNENSG00000123240.123212.482601517.711601.0817017.0672016.10040HepG2SRFBP1
OPTNENSG00000123240.12713.93080484.091900.560403.072901.36170HepG2SRP68
OPTNENSG00000123240.12783.482402795.50870-1.8351096.9093095.05290HepG2SRSF1
OPTNENSG00000123240.121059.87150705.556300.587004.172702.91830HepG2SRSF3
OPTNENSG00000123240.121053.073001259.28160-0.258002.211801.64500HepG2SRSF5
OPTNENSG00000123240.121929.05050911.762301.0811038.6555036.67910HepG2SRSF7
OPTNENSG00000123240.122679.749602274.374500.236503.453402.85130HepG2SRSF9
OPTNENSG00000123240.121728.471501317.875500.391202.306001.82820HepG2SSB
OPTNENSG00000123240.121561.522001129.109600.467703.031201.74220HepG2STAU1
OPTNENSG00000123240.121934.43410991.026600.964809.167407.06460HepG2SUB1
OPTNENSG00000123240.12896.449701432.07900-0.6758014.9482013.68940HepG2SUCLG1
OPTNENSG00000123240.121885.545001141.513100.723908.494206.91130HepG2SUPT6H
OPTNENSG00000123240.121823.45790505.979201.8494037.1143035.19160HepG2SUPV3L1
OPTNENSG00000123240.121537.083302512.96770-0.7092016.7633015.55070HepG2TAF15
OPTNENSG00000123240.12989.21730645.773200.615206.103205.08520HepG2TARDBP
OPTNENSG00000123240.121658.247703536.28570-1.092607.408705.76200HepG2TBRG4
OPTNENSG00000123240.12699.37120339.101901.044209.968008.30830HepG2TFIP11
OPTNENSG00000123240.122991.203402308.803800.373502.739901.90750HepG2TIA1
OPTNENSG00000123240.121110.44450764.040100.539306.596205.88460HepG2TIAL1
OPTNENSG00000123240.12747.050801064.72090-0.511202.910201.40900HepG2TRA2A
OPTNENSG00000123240.121172.79300770.918900.6052011.0755010.05980HepG2TRIM56
OPTNENSG00000123240.121870.851301446.417600.371102.557701.95160HepG2U2AF1
OPTNENSG00000123240.122632.330801319.001400.9968015.4376013.44300HepG2UBE2L3
OPTNENSG00000123240.12687.52760463.156900.569802.535401.57690HepG2UPF2
OPTNENSG00000123240.121221.542201551.47770-0.344902.416801.42680HepG2UTP18
OPTNENSG00000123240.12506.067701457.31470-1.5259051.9780049.89750HepG2UTP3
OPTNENSG00000123240.121462.907101042.705700.488402.753401.49250HepG2XRCC5
OPTNENSG00000123240.12596.259301166.18210-0.967809.274707.46110HepG2XRCC6
OPTNENSG00000123240.123115.907901660.107600.9083021.0233019.86110HepG2ZNF622
OPTNENSG00000123240.12834.91940465.338700.843309.502907.29160K562ABCF1
OPTNENSG00000123240.121132.11680873.385800.374204.561403.86460K562AGGF1
OPTNENSG00000123240.121336.03720959.765100.477105.031803.61050K562AKAP8
OPTNENSG00000123240.121962.14330908.808801.1103024.5574022.24570K562AKAP8L
OPTNENSG00000123240.12457.65170665.08970-0.539304.535502.88330K562APOBEC3C
OPTNENSG00000123240.121474.25820953.580700.6285011.265409.25380K562ATP5C1
OPTNENSG00000123240.12671.05670388.956300.786706.277104.95120K562BOP1
OPTNENSG00000123240.12514.93280324.134000.667704.646502.74510K562BUD13
OPTNENSG00000123240.12300.57880174.523200.784204.926603.42720K562CCAR1
OPTNENSG00000123240.121510.129601043.707000.532907.500805.55740K562CCDC124
OPTNENSG00000123240.12679.88960481.276800.498304.220202.34630K562CEBPZ
OPTNENSG00000123240.12954.97810645.519100.564903.428401.98990K562CIRBP
OPTNENSG00000123240.12967.09320561.948900.783107.586205.09100K562CKAP4
OPTNENSG00000123240.12956.67050649.767300.558002.681401.64140K562CNOT7
OPTNENSG00000123240.12784.29070413.525800.9233012.7786011.08250K562CPSF6
OPTNENSG00000123240.121520.95660926.996600.7142010.888209.02270K562CELF1
OPTNENSG00000123240.12786.96650553.190000.508404.993803.33380K562DDX21
OPTNENSG00000123240.12739.29070977.87210-0.403503.958002.88590K562DKC1
OPTNENSG00000123240.12276.71970187.671200.560102.737801.40340K562DNAJC21
OPTNENSG00000123240.12500.75910291.400900.781004.963703.20980K562EEF2
OPTNENSG00000123240.12759.99350558.257900.445004.885103.25740K562EIF2S1
OPTNENSG00000123240.12574.05450301.317100.929807.558005.71110K562EIF3D
OPTNENSG00000123240.121176.72090753.773700.642509.523707.81910K562EIF4G2
OPTNENSG00000123240.12604.18640355.678800.764303.387001.55000K562ESF1
OPTNENSG00000123240.12655.71340334.507900.9709011.519609.66280K562FIP1L1
OPTNENSG00000123240.12693.16690420.842300.719806.673905.32460K562FMR1
OPTNENSG00000123240.12660.93820356.740700.889508.880207.15400K562FTO
OPTNENSG00000123240.12515.62010372.792900.467803.747202.15070K562FUS
OPTNENSG00000123240.12330.76670552.16520-0.739307.054606.14930K562FXR1
OPTNENSG00000123240.12723.13450407.720900.826609.843107.81420K562GLRX3
OPTNENSG00000123240.12801.37820394.778401.0213013.8556012.05740K562GPKOW
OPTNENSG00000123240.12613.98110461.560800.411602.400901.69440K562GRSF1
OPTNENSG00000123240.12667.19230355.228300.909305.201102.47800K562HLTF
OPTNENSG00000123240.12929.54140583.029300.672903.606001.53930K562HNRNPA0
OPTNENSG00000123240.12653.64650460.679900.504604.288102.95320K562HNRNPA1
OPTNENSG00000123240.121435.83570809.353000.826904.428302.77640K562HNRNPA2B1
OPTNENSG00000123240.12918.77220371.203901.3074023.6975022.02490K562HNRNPC
OPTNENSG00000123240.12162.33960275.14100-0.761203.911502.79150K562HNRNPM
OPTNENSG00000123240.12589.96210453.516700.379402.095801.40040K562HSPD1
OPTNENSG00000123240.121234.41670593.176501.057207.997505.58250K562ILF2
OPTNENSG00000123240.12485.66570182.337201.4133016.9479013.74580K562ILF3
OPTNENSG00000123240.12312.66210176.208700.827205.567203.46940K562KHDRBS1
OPTNENSG00000123240.121746.73140964.433500.8568016.5033013.81150K562KIF1C
OPTNENSG00000123240.12727.10160337.188501.1085010.500808.55970K562KRR1
OPTNENSG00000123240.12222.35170331.07870-0.574302.976801.38020K562LSM11
OPTNENSG00000123240.12389.64770632.98400-0.700005.138003.98480K562MAGOH
OPTNENSG00000123240.121322.34250923.232500.518205.368003.70330K562MAK16
OPTNENSG00000123240.12532.80880385.363400.467302.547401.71120K562METAP2
OPTNENSG00000123240.121652.37370803.419301.0402017.8589015.27580K562MSI2
OPTNENSG00000123240.121366.00370757.295900.850908.408806.53830K562NAA15
OPTNENSG00000123240.12839.43740476.256000.817606.827705.72660K562NSUN2
OPTNENSG00000123240.12920.23840624.236800.559802.921501.65020K562PABPC1
OPTNENSG00000123240.121154.12270708.165200.704503.320902.20780K562PABPN1
OPTNENSG00000123240.121000.60390690.846100.534304.126103.10850K562PCBP3
OPTNENSG00000123240.12644.14290379.737700.762307.471805.98350K562PPIG
OPTNENSG00000123240.12218.83880332.83310-0.604903.348902.34130K562PSIP1
OPTNENSG00000123240.12403.35620614.96920-0.608505.634704.71660K562PTBP1
OPTNENSG00000123240.121428.00130822.401000.796004.910703.82760K562PUF60
OPTNENSG00000123240.121099.77340857.077600.359603.157702.13380K562PUM2
OPTNENSG00000123240.122004.39570901.207801.1531023.5714022.00290K562PUS1
OPTNENSG00000123240.12823.44730485.780100.761304.559402.66870K562RAVER1
OPTNENSG00000123240.121516.13390878.158500.7877016.1364014.69060K562RBM15
OPTNENSG00000123240.12697.47150482.566400.531302.904201.53580K562RBM25
OPTNENSG00000123240.121499.18800871.262500.782903.561801.76220K562RBM39
OPTNENSG00000123240.12398.32820620.63200-0.639804.811203.32370K562NELFE
OPTNENSG00000123240.12480.90700278.971700.785502.763501.94780K562RPS19
OPTNENSG00000123240.12622.78580280.019901.1531010.045907.63340K562RRP9
OPTNENSG00000123240.12299.76380472.18020-0.655505.047703.58500K562SAFB
OPTNENSG00000123240.12364.60190192.218800.923507.379505.33990K562SLBP
OPTNENSG00000123240.121130.19410743.720000.603602.416401.30150K562SNRNP200
OPTNENSG00000123240.12232.14410602.85330-1.3768021.0764019.14190K562SRSF1
OPTNENSG00000123240.12684.28390493.708700.470804.359402.86910K562SRSF7
OPTNENSG00000123240.12742.14830401.418600.886509.129606.80180K562STAU1
OPTNENSG00000123240.121136.21390579.270300.971805.618503.31420K562STIP1
OPTNENSG00000123240.12933.55180717.541400.379602.914801.36830K562SUCLG1
OPTNENSG00000123240.121483.75450889.734400.737703.409201.76540K562SUPT6H
OPTNENSG00000123240.12443.46780265.118100.742104.808203.43890K562SUPV3L1
OPTNENSG00000123240.12156.70420531.51010-1.7621030.2685027.87320K562SYNCRIP
OPTNENSG00000123240.12802.04090499.840400.682103.320901.66580K562TAF15
OPTNENSG00000123240.12807.33090610.173400.403802.783602.07470K562TARDBP
OPTNENSG00000123240.12736.37370530.414100.473203.476301.67900K562TBRG4
OPTNENSG00000123240.12546.63940320.124000.771906.259104.79480K562TIAL1
OPTNENSG00000123240.12662.23420391.286800.759007.193704.83140K562TRIP6
OPTNENSG00000123240.12876.71050521.997400.748005.588303.76070K562TROVE2
OPTNENSG00000123240.121446.67470927.375100.641407.690805.46330K562UBE2L3
OPTNENSG00000123240.12547.58770280.649700.964208.935307.03500K562UCHL5
OPTNENSG00000123240.12894.10680504.987300.8241010.078408.81900K562UPF1
OPTNENSG00000123240.121411.98780913.812900.627703.081501.68790K562UTP18
OPTNENSG00000123240.12907.51700468.968800.952304.236802.74360K562UTP3
OPTNENSG00000123240.12884.14000432.096901.0328017.0403014.87890K562WDR3
OPTNENSG00000123240.12593.20410449.363400.400503.718402.74760K562WDR43
OPTNENSG00000123240.121850.53930713.054601.3758013.5972011.53680K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for OPTN is not available on ENCORE database.





15 RBPs can affect the splicing of OPTN :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEOPTNENSG00000123240.12chr10+1316778413167836131674171316756713167945131680390.132000.000280.00749includedK562SRSF1
SEOPTNENSG00000123240.12chr10+131509611315101513150137131502891315111113151288-0.116000.004710.07230excludedHepG2U2AF1
SEOPTNENSG00000123240.12chr10+131501371315028913142172131423021315111113151288-0.187000.000000.00004excludedHepG2HNRNPK
SEOPTNENSG00000123240.12chr10+1315013713150289131421721314230213151111131512880.160000.000010.00308includedHepG2DDX59
SEOPTNENSG00000123240.12chr10+131501371315028913142172131423021315111113151288-0.107000.000070.00971excludedHepG2TBRG4
SEOPTNENSG00000123240.12chr10+131509611315101513150137131502891315111113151288-0.133000.000010.00026excludedHepG2U2AF2
SEOPTNENSG00000123240.12chr10+131501371315028913142172131423021315111113151288-0.140000.000670.04343excludedHepG2AKAP1
SEOPTNENSG00000123240.12chr10+1315013713150289131421721314230213151111131512880.191000.009070.07513includedK562AQR
SEOPTNENSG00000123240.12chr10+131501371315028913142172131423021315111113151288-0.145000.000140.01687excludedHepG2DDX3X
SEOPTNENSG00000123240.12chr10+1315013713150289131421721314230213151111131512880.196000.000130.02914includedHepG2TIA1
SEOPTNENSG00000123240.12chr10+131501371315028913142172131423021315111113151288-0.193000.000000.00001excludedHepG2NCBP2
SEOPTNENSG00000123240.12chr10+1315013713150289131421721314230213151111131512880.129000.000440.03300includedHepG2FTO
SEOPTNENSG00000123240.12chr10+131501371315028913142172131423021315111113151288-0.143000.000290.02709excludedHepG2IGF2BP3
SEOPTNENSG00000123240.12chr10+1315013713150289131421721314230213151111131512880.211000.000230.04054includedK562ZC3H8
SEOPTNENSG00000123240.12chr10+131501371315028913142172131423021315111113151288-0.119000.000640.02737excludedHepG2HNRNPC
A3SSOPTNENSG00000123240.12chr10+131608871316104013160905131610401315826613158340-0.339000.000000.00000shorterHepG2U2AF2

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for OPTN is not avaliable on ENCORE database.