FGB

General Information

Gene Name       : FGB
Gene ID             : ENSG00000171564.11
Essential Gene : No

Functions

Localization

Domains (AlphaFold: FGB)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878FGBENSG00000171564.110.000.030.01ENCSR000AEF
HepG2FGBENSG00000171564.11677.90694.71686.31ENCSR985KAT
K562FGBENSG00000171564.110.000.000.00ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for FGB is not avaliable on ENCORE database.



Proteins bound to RNA
  • FGB RNA is bound by 9 proteins.  







eCLIP assay for FGB is not avaliable on ENCORE database.





9 proteins are bound to FGB RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr4155487658155487697+3'-UTR,CDS,intron-Distal3.7636525.72106HepG2RPS3
chr4155487046155487095+3'-UTR,CDS,intron-Distal4.9018543.56374HepG2RPS3
chr4155487640155487677+3'-UTR,CDS,intron-Distal,intron-Proximal5.99809400.00000HepG2SND1
chr4155487640155487658+3'-UTR,CDS,intron-Distal,intron-Proximal4.5014623.82883HepG2RPS3
chr4155487148155487151+3'-UTR,CDS,intron-Distal6.51940400.00000HepG2SND1
chr4155487683155487684+3'-UTR,CDS,intron-Distal4.0976722.16998HepG2SND1
chr4155487056155487093+3'-UTR,CDS,intron-Distal4.73902400.00000HepG2SND1
chr4155491878155491931+3'-UTR4.936034.74172HepG2TIAL1
chr4155486970155487043+3'-UTR,CDS,intron-Distal3.96657400.00000HepG2SND1
chr4155487104155487126+3'-UTR,CDS,intron-Distal5.3681870.67087HepG2SND1
chr4155487116155487152+3'-UTR,CDS,intron-Distal,intron-Proximal4.3485314.52429HepG2RPS3
chr4155487003155487044+3'-UTR,CDS,intron-Distal4.2113252.12198HepG2RPS3
chr4155491754155491804+3'-UTR,CDS3.4606017.79452HepG2LIN28B
chr4155491720155491804+3'-UTR,CDS3.0314518.01035HepG2LARP4
chr4155487749155487758+3'-UTR,CDS,intron-Distal4.206358.51824HepG2RPS3
chr4155487126155487148+3'-UTR,CDS,intron-Distal6.47624400.00000HepG2SND1
chr4155486963155487003+3'-UTR,CDS,intron-Distal3.6397833.84128HepG2RPS3
chr4155487043155487056+3'-UTR,CDS,intron-Distal4.53831400.00000HepG2SND1
chr4155486960155486977+3'-UTR,CDS,intron-Distal3.4271711.29076HepG2LIN28B
chr4155491876155491932+3'-UTR3.892263.44480HepG2TIA1
chr4155490693155490698+CDS,intron-Distal4.9115436.56767HepG2SND1
chr4155490686155490732+CDS,intron-Distal4.5592127.94401HepG2LIN28B
chr4155490752155490767+CDS,intron-Distal3.7815529.22882HepG2SND1
chr4155490370155490409+CDS4.3530245.33614HepG2SND1
chr4155490419155490437+CDS6.4753463.60489HepG2SND1
chr4155491599155491648+CDS4.1793850.18962HepG2SND1
chr4155490437155490459+CDS6.72191110.37629HepG2SND1
chr4155490665155490674+CDS,intron-Distal,intron-Proximal3.317305.20917HepG2BCLAF1
chr4155490922155490951+CDS,intron-Distal4.5083430.20687HepG2SND1
chr4155490665155490680+CDS,intron-Distal,intron-Proximal6.2969055.60477HepG2SND1
chr4155490347155490369+CDS4.1616931.71729HepG2SND1
chr4155490698155490752+CDS,intron-Distal4.94515400.00000HepG2SND1
chr4155490750155490819+CDS,intron-Distal3.4472523.27634HepG2RPS3
chr4155490407155490456+CDS3.6128726.32943HepG2RPS3
chr4155490848155490869+CDS,intron-Distal4.1973836.27449HepG2SND1
chr4155488919155488960+CDS4.5647356.95534HepG2SND1
chr4155491735155491761+CDS3.324964.07060HepG2ZNF800
chr4155491571155491572+CDS3.9791818.42511HepG2SND1
chr4155490836155490848+CDS,intron-Distal3.8725722.01349HepG2SND1
chr4155490435155490459+CDS3.8659216.08576HepG2BCLAF1
chr4155491603155491690+CDS3.5820221.49264HepG2RPS3
chr4155490335155490435+CDS3.0175718.91432HepG2BCLAF1
chr4155491656155491711+CDS4.79984400.00000HepG2SND1
chr4155490433155490459+CDS3.143974.82171HepG2ZNF800
chr4155489548155489606+CDS3.3547111.48054HepG2BCLAF1
chr4155490831155490860+CDS,intron-Distal3.019638.42375HepG2BCLAF1
chr4155490338155490380+CDS3.3386721.02538HepG2RPS3
chr4155484567155484624+intron-Distal3.993825.18845HepG2U2AF2
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for FGB is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for FGB is not available on ENCORE database.

  • 172 RBPs can affect the levels of FGB.  








The Knockdown/knockout RNA-Seq assay for FGB is not available on ENCORE database.





172 RBPs can affect the gene expression of FGB :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
FGBENSG00000171564.715055.061208673.824500.795409.492406.57640HepG2AARS
FGBENSG00000171564.781151.4537014796.811402.45520129.43280125.82340HepG2ABCF1
FGBENSG00000171564.78763.9314011556.80240-0.3991012.6253011.52850HepG2ACO1
FGBENSG00000171564.731484.734508493.799401.8901059.1613055.88220HepG2ADAR
FGBENSG00000171564.717440.8618022661.36680-0.377802.933702.38790HepG2AKAP1
FGBENSG00000171564.727991.4411011027.367701.3438020.6116018.11390HepG2AKAP8
FGBENSG00000171564.731268.3979011611.550701.4290036.7907034.51810HepG2AKAP8L
FGBENSG00000171564.722633.5126018750.981400.271402.116301.42450HepG2ASCC1
FGBENSG00000171564.723370.9319013354.652800.8073020.8227017.59450HepG2ATP5C1
FGBENSG00000171564.727323.8767011755.862901.2167088.7475085.95240HepG2AUH
FGBENSG00000171564.722401.593108849.548101.3398032.2555028.83480HepG2BCCIP
FGBENSG00000171564.711297.422907690.696000.554707.053305.69780HepG2BCLAF1
FGBENSG00000171564.753979.522706447.924803.06540218.14400214.88570HepG2BOP1
FGBENSG00000171564.723281.1236011087.188301.0702035.1346031.67500HepG2BUD13
FGBENSG00000171564.727535.754309980.677101.4640067.7417064.98900HepG2CALR
FGBENSG00000171564.728078.6804018038.548600.638306.444104.93620HepG2CCAR1
FGBENSG00000171564.728224.4240014892.835800.922208.731905.45790HepG2CDC40
FGBENSG00000171564.743271.0649017814.528401.2802036.2831033.98560HepG2CIRBP
FGBENSG00000171564.719610.7096011554.833400.7630055.0376052.97350HepG2CKAP4
FGBENSG00000171564.74975.9013010513.00350-1.0791011.8986010.35130HepG2CNOT7
FGBENSG00000171564.763642.829305919.258603.42640238.19550234.42130HepG2CPSF6
FGBENSG00000171564.714722.1949012186.871100.272603.082501.91590HepG2CPSF7
FGBENSG00000171564.77196.641805467.922100.396202.463501.44650HepG2CSTF2
FGBENSG00000171564.720670.9809012809.887300.690206.974104.50240HepG2CSTF2T
FGBENSG00000171564.727623.0791011824.837701.2240081.4357078.98790HepG2CELF1
FGBENSG00000171564.79688.0059012714.04980-0.3922014.3686012.90430HepG2DAZAP1
FGBENSG00000171564.724367.7731010688.636001.18880100.8663097.77550HepG2DDX19B
FGBENSG00000171564.712165.704908722.271300.479906.375104.69810HepG2DDX1
FGBENSG00000171564.711549.4985013806.40350-0.257502.485501.83950HepG2DDX21
FGBENSG00000171564.780671.0248013508.985102.57800212.65730208.29220HepG2DDX24
FGBENSG00000171564.724820.070108142.150401.6079042.0999038.33200HepG2DDX27
FGBENSG00000171564.714692.090506593.170401.1559028.5582025.20220HepG2DDX28
FGBENSG00000171564.749387.7808021709.169601.1857028.3129026.53960HepG2DDX3X
FGBENSG00000171564.713161.187908700.355000.597004.842103.85270HepG2DDX55
FGBENSG00000171564.716903.766206721.848001.3303014.4739012.38270HepG2DDX59
FGBENSG00000171564.743567.7681013063.001601.7377068.0867064.91240HepG2DDX5
FGBENSG00000171564.728950.9900018645.577300.634707.471506.50190HepG2DDX6
FGBENSG00000171564.711731.928408249.078500.508007.752806.19020HepG2DHX30
FGBENSG00000171564.752698.1732011056.868502.25270295.00000291.56880HepG2DKC1
FGBENSG00000171564.716897.177308552.532800.9823016.6843015.09890HepG2DNAJC21
FGBENSG00000171564.711553.407908477.724300.4465018.4138016.87650HepG2DNAJC2
FGBENSG00000171564.732100.9502012322.781601.3812045.1460042.50080HepG2EEF2
FGBENSG00000171564.728372.2262013036.822701.1218043.5803040.69630HepG2EIF3G
FGBENSG00000171564.734873.5040019813.426800.8156011.8889010.59020HepG2EIF4A3
FGBENSG00000171564.776627.2441019288.358101.9900048.7752046.19450HepG2EIF4B
FGBENSG00000171564.727086.6098012543.667701.1105037.2209034.91200HepG2EIF4G1
FGBENSG00000171564.739923.1130012015.945301.7322028.4064026.08880HepG2EIF4G2
FGBENSG00000171564.746119.7834012818.655001.8470056.7488053.37420HepG2ESF1
FGBENSG00000171564.723596.1683013496.213900.8059022.9065021.46150HepG2ETF1
FGBENSG00000171564.718473.0771011293.542500.7098016.5174014.59530HepG2EWSR1
FGBENSG00000171564.713840.806108940.604200.6304015.3306012.67130HepG2FAM120A
FGBENSG00000171564.76324.1631014941.50570-1.2404027.0243025.08760HepG2FIP1L1
FGBENSG00000171564.715330.932007242.464001.0818024.2930021.35340HepG2FKBP4
FGBENSG00000171564.716310.6134011895.171300.455303.879501.91770HepG2FMR1
FGBENSG00000171564.743472.049505930.002802.8739038.6378035.48290HepG2FTO
FGBENSG00000171564.723063.5636015581.054800.565704.451703.05570HepG2FUS
FGBENSG00000171564.710839.1253019986.48880-0.8828012.2714010.91980HepG2FXR1
FGBENSG00000171564.736747.0124018542.728500.9867014.2170012.76900HepG2G3BP1
FGBENSG00000171564.726675.3667019682.439500.438504.920903.72270HepG2G3BP2
FGBENSG00000171564.738947.2944013089.767601.5730050.0986046.42230HepG2GNB2L1
FGBENSG00000171564.797346.589706709.152703.85880221.77610218.17980HepG2GPKOW
FGBENSG00000171564.713770.771009731.316100.500803.477802.22620HepG2GRSF1
FGBENSG00000171564.729733.8858012149.976001.2911028.7842024.72270HepG2GRWD1
FGBENSG00000171564.722591.565208634.476201.3875020.9125019.42410HepG2HNRNPA1
FGBENSG00000171564.732908.4928011684.843201.49370134.25380130.17400HepG2HNRNPA2B1
FGBENSG00000171564.712545.632508677.930700.531704.628202.79910HepG2HNRNPAB
FGBENSG00000171564.731801.581308704.981301.86910139.59850136.32690HepG2HNRNPF
FGBENSG00000171564.713924.4729018770.75390-0.430904.802003.90310HepG2HNRNPK
FGBENSG00000171564.723569.9761011581.358201.02500107.18050104.13260HepG2HNRNPL
FGBENSG00000171564.756801.902406402.739303.14910192.44150188.92350HepG2HNRNPLL
FGBENSG00000171564.76795.5280010309.76690-0.6014011.9495010.21550HepG2HNRNPM
FGBENSG00000171564.719576.727309540.978601.0368030.6700028.83680HepG2HNRNPU
FGBENSG00000171564.720699.9172012011.726700.785103.247601.91160HepG2HSPD1
FGBENSG00000171564.731583.427608571.911301.88140119.67300116.43510HepG2IGF2BP1
FGBENSG00000171564.728835.2784018849.107000.613208.572807.45500HepG2IGF2BP2
FGBENSG00000171564.75559.933009745.75330-0.8097028.5982026.56030HepG2ILF2
FGBENSG00000171564.713452.3715010013.842200.425803.205801.90270HepG2KHDRBS1
FGBENSG00000171564.79163.7776010564.70400-0.205204.468403.18570HepG2KIF1C
FGBENSG00000171564.735454.4850012000.092301.5628013.5391010.94920HepG2KRR1
FGBENSG00000171564.740127.2211019039.717301.0755017.3129015.25210HepG2LARP4
FGBENSG00000171564.77260.8881012821.26070-0.820307.623905.81740HepG2LARP7
FGBENSG00000171564.729574.3962013466.213901.1349035.4654032.04820HepG2LIN28B
FGBENSG00000171564.741317.6017019993.446601.0471022.3769020.61010HepG2MAGOH
FGBENSG00000171564.727574.7537020106.067800.455604.359503.58340HepG2MATR3
FGBENSG00000171564.718818.2965012093.899500.6378014.0390012.37040HepG2MSI2
FGBENSG00000171564.730470.179206531.684702.2218010.965609.02530HepG2MTPAP
FGBENSG00000171564.729572.2428020580.264000.522903.437402.73480HepG2NCBP2
FGBENSG00000171564.728690.2824011593.652201.3071036.5539032.49500HepG2NIP7
FGBENSG00000171564.717234.1807011381.039600.598502.794101.35670HepG2NKRF
FGBENSG00000171564.75495.889007986.22280-0.539202.366501.36160HepG2NONO
FGBENSG00000171564.730287.057905677.825102.4152067.5334064.82780HepG2NSUN2
FGBENSG00000171564.720495.5568011674.620000.811804.275002.28000HepG2NUP35
FGBENSG00000171564.74331.245109607.76990-1.1494011.615309.76680HepG2PABPC1
FGBENSG00000171564.725260.8043018330.757500.462504.896603.94680HepG2PABPC4
FGBENSG00000171564.717762.453109443.639000.9113051.6050048.94710HepG2PARN
FGBENSG00000171564.725348.0612019117.381100.4069011.9353010.81670HepG2PCBP1
FGBENSG00000171564.751129.9527014750.327701.7933034.1232031.00520HepG2PCBP2
FGBENSG00000171564.714618.2606010990.650200.411404.314402.17040HepG2PES1
FGBENSG00000171564.720061.5505012307.005900.704908.622905.86090HepG2PHF6
FGBENSG00000171564.711872.476408509.749200.4803011.5468010.09910HepG2PPIL4
FGBENSG00000171564.715058.769506919.448801.1218023.9699022.10490HepG2PRPF4
FGBENSG00000171564.733065.9723015506.796601.0923013.2256010.87920HepG2PRPF6
FGBENSG00000171564.723656.161406714.812301.8167066.8500063.71340HepG2PRPF8
FGBENSG00000171564.711146.2615019452.28040-0.8034015.0797014.00020HepG2PTBP1
FGBENSG00000171564.729656.2865012034.881701.3010050.7192048.56870HepG2PUF60
FGBENSG00000171564.716064.5907012775.737500.3304012.3468011.28380HepG2PUM1
FGBENSG00000171564.747764.8345012766.294201.90350136.16150132.24200HepG2PUM2
FGBENSG00000171564.78826.5868011771.43230-0.4154013.6189012.43040HepG2PUS1
FGBENSG00000171564.74001.9779014236.12240-1.8308024.4688022.57620HepG2RAVER1
FGBENSG00000171564.723387.5419016536.610500.5000010.914609.38340HepG2RBM15
FGBENSG00000171564.716146.2934011280.564700.517303.097802.55780HepG2RBM22
FGBENSG00000171564.736990.2274017341.004101.092904.025502.02320HepG2RBM39
FGBENSG00000171564.780367.8873021648.827601.89220168.04100165.53890HepG2NELFE
FGBENSG00000171564.728511.5032020162.383600.4998018.5840017.22220HepG2RECQL
FGBENSG00000171564.747887.531109377.552002.35230133.01270130.06920HepG2RPLP0
FGBENSG00000171564.734856.8275013981.082101.3179018.7836016.57960HepG2RPS10
FGBENSG00000171564.76319.005809733.74140-0.6233012.6739011.47330HepG2RPS19
FGBENSG00000171564.722819.1541014258.962300.678305.628204.51150HepG2RPS2
FGBENSG00000171564.734941.5719010553.223601.7272037.5529034.78640HepG2RPS3A
FGBENSG00000171564.712659.933106642.652600.9303017.1526015.49970HepG2RRP9
FGBENSG00000171564.74313.504508496.52380-0.9780027.1520025.42520HepG2SAFB2
FGBENSG00000171564.715971.0168010027.111600.671505.061803.02560HepG2SBDS
FGBENSG00000171564.730469.665109769.134701.6410060.7038057.19480HepG2SERBP1
FGBENSG00000171564.767152.3882027656.180601.2797010.697709.30900HepG2SF3A3
FGBENSG00000171564.725371.874306336.992102.0013096.3663093.38020HepG2SF3B1
FGBENSG00000171564.723359.9579011539.943201.0173089.1806086.53390HepG2SLBP
FGBENSG00000171564.733272.1110013886.736701.260508.771406.11950HepG2SLTM
FGBENSG00000171564.74590.377009908.14720-1.1100050.2475048.15140HepG2SMN1
FGBENSG00000171564.719897.5852014506.256000.455803.188702.15300HepG2SMNDC1
FGBENSG00000171564.7192693.653407051.178104.77220183.41890179.04270HepG2SNRNP70
FGBENSG00000171564.713161.661708287.723100.667204.171502.23460HepG2SRP68
FGBENSG00000171564.736813.9148021139.474200.8002019.9986018.97280HepG2SRSF1
FGBENSG00000171564.712317.439606819.919100.852803.717702.53960HepG2SRSF3
FGBENSG00000171564.718961.4325011882.907300.6741031.1705029.39110HepG2SRSF5
FGBENSG00000171564.736592.011208552.392202.09700258.59820254.51120HepG2SRSF7
FGBENSG00000171564.742363.9019017197.855201.30050126.91070124.41610HepG2SRSF9
FGBENSG00000171564.7168102.3396011063.239703.9254099999.9999999999.99999HepG2SSB
FGBENSG00000171564.720148.1723011962.492800.7520010.072207.86020HepG2SSRP1
FGBENSG00000171564.724536.130509981.052301.297508.749606.70690HepG2STAU1
FGBENSG00000171564.721342.384609178.971301.2172020.2402017.18020HepG2STIP1
FGBENSG00000171564.723085.6056013303.530300.795107.901405.94230HepG2SUB1
FGBENSG00000171564.722694.1571013513.955500.7478051.9832049.89570HepG2SUCLG1
FGBENSG00000171564.717185.8031010090.268500.7682019.4242017.19030HepG2SUPT6H
FGBENSG00000171564.762151.222608661.994902.84290108.25670105.29880HepG2SUPV3L1
FGBENSG00000171564.711649.0990019000.23290-0.7058025.8238024.34230HepG2TAF15
FGBENSG00000171564.728596.911506242.778202.19550107.82020104.53030HepG2TARDBP
FGBENSG00000171564.730500.2392011750.070601.3761011.821309.80660HepG2TBRG4
FGBENSG00000171564.711385.440605806.395500.9714018.7702016.68820HepG2TFIP11
FGBENSG00000171564.724669.9021017459.422200.498609.459407.92980HepG2TIA1
FGBENSG00000171564.711323.352309269.954900.288603.904503.33190HepG2TIAL1
FGBENSG00000171564.79316.9981014291.76960-0.617205.188403.21950HepG2TRA2A
FGBENSG00000171564.712355.295809353.775500.4014011.0978010.08010HepG2TRIM56
FGBENSG00000171564.762611.6936011757.862302.41270182.39320178.01200HepG2TUFM
FGBENSG00000171564.732894.9733012782.182901.3636035.4473033.14710HepG2U2AF1
FGBENSG00000171564.716685.8126012445.704500.422904.139603.10530HepG2UBE2L3
FGBENSG00000171564.71886.348805117.53930-1.4399011.8589010.30440HepG2UCHL5
FGBENSG00000171564.753764.6381024526.713601.13220101.3993098.54530HepG2UPF1
FGBENSG00000171564.735631.222207934.174002.1669058.2290054.33920HepG2UPF2
FGBENSG00000171564.745905.7755025210.709500.864509.562207.75230HepG2UTP18
FGBENSG00000171564.764421.0101023679.716601.44380151.00580147.66120HepG2UTP3
FGBENSG00000171564.713219.302509452.357800.483803.384602.16420HepG2XPO5
FGBENSG00000171564.731153.8249015654.303900.9927012.2245010.17060HepG2XRCC6
FGBENSG00000171564.716620.671508526.756100.9628022.4798020.50060HepG2XRN2
FGBENSG00000171564.726304.005506828.143301.94560107.85610105.08200HepG2ZC3H8
FGBENSG00000171564.763481.6615026974.817501.23460171.87850169.50560HepG2ZNF622
FGBENSG00000171564.725713.9345014220.046000.8545010.064907.50870HepG2ZRANB2
FGBENSG00000171564.72.5091026.03710-3.375303.347201.67340K562CEBPZ
FGBENSG00000171564.73.3464029.91740-3.160303.136701.84150K562DDX21
FGBENSG00000171564.714.020300.0000099999.999904.381701.90480K562EIF3H
FGBENSG00000171564.70.0000012.80380-99999.999994.086903.04370K562FMR1
FGBENSG00000171564.71.0471010.85470-3.373802.160201.35710K562FTO
FGBENSG00000171564.70.0000012.00700-99999.999993.690302.77860K562GPKOW
FGBENSG00000171564.70.0000010.25850-99999.999992.656401.74450K562KRR1
FGBENSG00000171564.75.84310161.83020-4.7916010.813009.32550K562MTPAP
FGBENSG00000171564.714.16760179.75300-3.665308.519507.31180K562NSUN2
FGBENSG00000171564.70.48950165.93900-8.4051016.1021013.19230K562NUFIP2
FGBENSG00000171564.77.91220177.45200-4.4872010.247108.75130K562SF3A3
FGBENSG00000171564.76.20280181.81070-4.8734011.722009.95990K562SRPK2
FGBENSG00000171564.74.40400190.60020-5.4356012.8159011.40730K562UPF1
FGBENSG00000171564.70.00000163.08350-99999.9999917.4510015.25820K562WDR3
FGBENSG00000171564.70.00000169.63670-99999.9999917.6756015.80440K562WDR43
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for FGB is not available on ENCORE database.






No RBPs affect the alternative splcing events of FGB on ENCORE database.





The Knockdown/knockout RNA-Seq assay for FGB is not avaliable on ENCORE database.