LEO1

General Information

Gene Name       : LEO1
Gene ID             : ENSG00000166477.12
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: LEO1)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878LEO1ENSG00000166477.1239.6534.4537.05ENCSR000AEF
HepG2LEO1ENSG00000166477.1247.9160.9454.42ENCSR985KAT
K562LEO1ENSG00000166477.1227.2832.5029.89ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for LEO1 is not avaliable on ENCORE database.



Proteins bound to RNA
  • LEO1 RNA is bound by 12 proteins.  







eCLIP assay for LEO1 is not avaliable on ENCORE database.





12 proteins are bound to LEO1 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr155223024152230329-3'-UTR,intron-Distal4.108795.38549K562PUM2
chr155223034752230398-3'-UTR,CDS,intron-Distal5.3834718.19808HepG2BCLAF1
chr155226390052263951-5'-UTR,CDS,intron-Distal4.7511216.91538HepG2GRWD1
chr155225286252252892-CDS,intron-Distal5.3000110.26368HepG2GRWD1
chr155226388852263912-CDS,intron-Distal3.463305.39086K562UCHL5
chr155225867652258695-CDS,intron-Distal3.967585.85226K562UCHL5
chr155225847752258612-CDS,intron-Distal4.9311532.33983HepG2GRWD1
chr155225286252252899-CDS,intron-Distal3.454279.60326HepG2BCLAF1
chr155226388552263932-CDS,intron-Distal4.041763.88696K562GRWD1
chr155225287052252894-CDS,intron-Distal4.856376.46917K562ZNF622
chr155225833852258413-CDS,intron-Distal4.251185.21253K562LIN28B
chr155223035752230397-CDS,intron-Distal3.735693.45590K562GRWD1
chr155226388452263900-CDS,intron-Distal4.1536511.73211HepG2GRWD1
chr155225853352258576-CDS,intron-Distal3.342769.33743HepG2BCLAF1
chr155225852852258582-CDS,intron-Distal3.199523.69997K562GRWD1
chr155224544352245460-CDS,intron-Distal4.1822710.98590HepG2BCLAF1
chr155225852152258584-CDS,intron-Distal3.314205.16541HepG2UCHL5
chr155224667752246715-CDS,intron-Distal,intron-Proximal3.636376.44869K562UCHL5
chr155224667752246712-CDS,intron-Distal,intron-Proximal4.1620912.83484HepG2BCLAF1
chr155225284752252880-CDS,intron-Distal3.985496.11943K562UCHL5
chr155224667952246686-CDS,intron-Distal3.699866.15459HepG2GRWD1
chr155224211152242179-CDS,intron-Distal4.0155220.68405HepG2BCLAF1
chr155225851552258589-CDS,intron-Distal3.8467915.34418K562UCHL5
chr155224211652242186-CDS,intron-Distal3.3518810.50393K562ZNF622
chr155225459452254643-CDS,intron-Distal3.9715412.83484HepG2BCLAF1
chr155224673452246762-CDS,intron-Distal3.241306.64701HepG2BCLAF1
chr155224539752245427-CDS,intron-Distal,intron-Proximal6.0465514.62138HepG2BCLAF1
chr155226383452263930-CDS,intron-Distal5.605799.06713HepG2PRPF8
chr155224211552242178-CDS,intron-Distal4.0954517.68963HepG2GRWD1
chr155225866152258701-CDS,intron-Distal3.361018.20826HepG2GRWD1
chr155224210452242188-CDS,intron-Distal3.5247512.80405K562UCHL5
chr155224679852246862-intron-Distal,intron-Proximal4.276723.76397K562SF3B4
chr155223612652236268-intron-Distal3.031383.33633HepG2MATR3
chr155223453952234617-intron-Distal3.184116.13708HepG2SUGP2
chr155225773552257787-intron-Distal3.944533.09122HepG2PTBP1
chr155226358252263656-intron-Distal5.5850610.15275HepG2RBFOX2
chr155223418752234258-intron-Distal3.454634.81844HepG2SUGP2
chr155223654352236600-intron-Distal3.403764.57452HepG2SUGP2
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for LEO1 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for LEO1 is not available on ENCORE database.

  • 148 RBPs can affect the levels of LEO1.  








The Knockdown/knockout RNA-Seq assay for LEO1 is not available on ENCORE database.





148 RBPs can affect the gene expression of LEO1 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
LEO1ENSG00000166477.81623.730204062.71370-1.3231029.8494027.48710HepG2ABCF1
LEO1ENSG00000166477.81854.152302780.58620-0.5846017.0561015.81820HepG2ACO1
LEO1ENSG00000166477.81106.625902128.20820-0.9435015.9739013.89430HepG2ADAR
LEO1ENSG00000166477.82654.793103807.92850-0.520404.650503.98340HepG2AKAP1
LEO1ENSG00000166477.81826.877502793.64960-0.6128016.1220014.48260HepG2AKAP8L
LEO1ENSG00000166477.82439.091003150.72390-0.369303.014002.19500HepG2ASCC1
LEO1ENSG00000166477.84683.962903449.453700.4413010.401209.21060HepG2AUH
LEO1ENSG00000166477.8292.302103583.01680-3.61560197.14800194.07680HepG2BOP1
LEO1ENSG00000166477.82244.107305142.27490-1.1963018.8424016.48430HepG2CCAR1
LEO1ENSG00000166477.81389.459102993.41020-1.1073021.9221020.00800HepG2CIRBP
LEO1ENSG00000166477.81731.011102779.98120-0.6835025.0690023.52120HepG2CKAP4
LEO1ENSG00000166477.83396.557902307.258900.557803.458802.59720HepG2CNOT7
LEO1ENSG00000166477.81820.229702182.46940-0.261802.825801.79700HepG2YBX3
LEO1ENSG00000166477.8614.259601064.91390-0.793809.222907.44470HepG2CSTF2
LEO1ENSG00000166477.82648.964703138.88190-0.244802.742802.10220HepG2CELF1
LEO1ENSG00000166477.81388.216602571.64350-0.8895036.8345034.67980HepG2DDX19B
LEO1ENSG00000166477.81817.133402185.47810-0.266302.805701.63800HepG2DDX1
LEO1ENSG00000166477.8796.823502115.41720-1.4086037.9690035.90760HepG2DDX21
LEO1ENSG00000166477.8815.355302069.98730-1.3441033.0284030.33540HepG2DDX24
LEO1ENSG00000166477.82614.126203647.67040-0.480604.651903.85710HepG2DDX3X
LEO1ENSG00000166477.81873.387102354.17780-0.329603.292701.81540HepG2DDX52
LEO1ENSG00000166477.82192.111403133.51160-0.515504.587503.80920HepG2DDX6
LEO1ENSG00000166477.81088.876802660.26730-1.2887059.5206057.46760HepG2DKC1
LEO1ENSG00000166477.81595.210802124.12170-0.413109.011707.91510HepG2DNAJC2
LEO1ENSG00000166477.81322.940802808.96440-1.0863021.1173018.99090HepG2EEF2
LEO1ENSG00000166477.82469.899503081.98400-0.319403.408102.10600HepG2EIF2S2
LEO1ENSG00000166477.81063.692302280.33360-1.1002018.4413016.37100HepG2EIF3D
LEO1ENSG00000166477.81117.542901997.59580-0.8379017.1596014.94770HepG2EIF3G
LEO1ENSG00000166477.81385.696803328.83080-1.2644022.9033021.10510HepG2EIF4A3
LEO1ENSG00000166477.81479.499503241.16400-1.1314014.8189013.30100HepG2EIF4B
LEO1ENSG00000166477.82229.386003519.39750-0.658709.891808.03040HepG2ESF1
LEO1ENSG00000166477.82363.398503960.39740-0.7448025.6838024.16930HepG2ETF1
LEO1ENSG00000166477.81739.382602717.12890-0.6435010.884009.25910HepG2EWSR1
LEO1ENSG00000166477.82467.335902015.859000.291502.549101.44640HepG2FASTKD2
LEO1ENSG00000166477.82311.011804102.38370-0.8279011.6412010.21760HepG2FIP1L1
LEO1ENSG00000166477.82845.812902221.668900.357103.315002.45940HepG2FUBP3
LEO1ENSG00000166477.81409.656002556.52890-0.858808.506806.66130HepG2FUS
LEO1ENSG00000166477.82175.508803358.77770-0.626607.646406.53940HepG2FXR1
LEO1ENSG00000166477.81933.772403115.69200-0.688108.105706.99820HepG2G3BP1
LEO1ENSG00000166477.81825.985103307.79370-0.8572014.0118012.02670HepG2G3BP2
LEO1ENSG00000166477.8697.337302030.36640-1.5418037.0534034.38270HepG2GEMIN5
LEO1ENSG00000166477.81370.740602306.82880-0.751009.268107.36700HepG2GNB2L1
LEO1ENSG00000166477.81798.532303728.80570-1.0519018.1681016.67790HepG2GPKOW
LEO1ENSG00000166477.81342.765002135.83560-0.669605.166103.63990HepG2GRSF1
LEO1ENSG00000166477.8673.861102163.50090-1.6828052.4504050.39250HepG2HNRNPA1
LEO1ENSG00000166477.82631.030003101.59150-0.237402.403501.52480HepG2HNRNPA2B1
LEO1ENSG00000166477.81171.721302406.51960-1.0383022.3453020.58060HepG2HNRNPC
LEO1ENSG00000166477.82275.661003155.07630-0.471405.275304.33360HepG2HNRNPK
LEO1ENSG00000166477.82868.759503558.46740-0.310802.443601.84690HepG2HNRNPLL
LEO1ENSG00000166477.81797.150102830.51840-0.6554011.556909.85020HepG2HNRNPM
LEO1ENSG00000166477.81893.264502390.60730-0.336505.656504.81480HepG2HNRNPU
LEO1ENSG00000166477.81496.350803167.00910-1.0817020.4058018.76620HepG2IGF2BP2
LEO1ENSG00000166477.81765.635602972.19700-0.751303.219002.15560HepG2IGF2BP3
LEO1ENSG00000166477.82149.853903185.51440-0.567304.581603.26140HepG2KHSRP
LEO1ENSG00000166477.82129.920105428.44800-1.3497024.3829021.86480HepG2LARP4
LEO1ENSG00000166477.81805.526602259.77490-0.323802.619101.51590HepG2LARP7
LEO1ENSG00000166477.81556.304802373.07560-0.608607.807905.85300HepG2LIN28B
LEO1ENSG00000166477.82067.708503359.95080-0.700409.103307.92610HepG2MAGOH
LEO1ENSG00000166477.81317.230501913.83790-0.539005.439603.25150HepG2MARK2
LEO1ENSG00000166477.81660.928403378.73540-1.0245016.1174014.68940HepG2MATR3
LEO1ENSG00000166477.81522.660202386.63190-0.648404.108102.83670HepG2METAP2
LEO1ENSG00000166477.81158.072903320.28010-1.5196054.2904051.58130HepG2MSI2
LEO1ENSG00000166477.81405.802903458.30680-1.2987026.6134024.79650HepG2NCBP2
LEO1ENSG00000166477.81514.198402043.34570-0.432404.084202.35060HepG2NIP7
LEO1ENSG00000166477.82806.740303346.29590-0.253702.510101.78620HepG2NOL12
LEO1ENSG00000166477.83140.824807018.39500-1.160004.234701.92220HepG2NUFIP2
LEO1ENSG00000166477.81694.506802295.93200-0.438203.594401.31500HepG2NUSAP1
LEO1ENSG00000166477.81414.069803079.77070-1.1230020.7398018.81330HepG2PABPC4
LEO1ENSG00000166477.82010.474102366.26080-0.235102.812201.95770HepG2PARN
LEO1ENSG00000166477.82344.054203044.87860-0.377402.735902.13160HepG2PCBP1
LEO1ENSG00000166477.81291.525201885.76460-0.546108.393106.35370HepG2PKM
LEO1ENSG00000166477.81733.890102132.22640-0.298303.521002.69960HepG2PPIL4
LEO1ENSG00000166477.82002.551802371.26260-0.243802.927502.13450HepG2PRPF4
LEO1ENSG00000166477.81452.154402544.32050-0.809106.957505.10950HepG2PRPF6
LEO1ENSG00000166477.8766.451101307.70740-0.770808.020806.72960HepG2PRPF8
LEO1ENSG00000166477.81552.209202579.14000-0.732604.121901.95610HepG2PSIP1
LEO1ENSG00000166477.82014.816303098.51000-0.620907.655106.83580HepG2PTBP1
LEO1ENSG00000166477.81486.503703194.45490-1.1036028.4926026.85060HepG2PUF60
LEO1ENSG00000166477.82669.846803388.63220-0.343902.386501.76310HepG2PUM2
LEO1ENSG00000166477.81432.267002832.20730-0.9836044.2449042.38500HepG2PUS1
LEO1ENSG00000166477.81114.295801644.17610-0.561204.878302.49810HepG2RBM14
LEO1ENSG00000166477.85901.291904450.545400.406906.662405.40460HepG2RBM15
LEO1ENSG00000166477.81555.769003310.16710-1.0893041.7095040.16440HepG2RBM22
LEO1ENSG00000166477.82200.947903045.30830-0.468503.911103.12000HepG2RBM25
LEO1ENSG00000166477.81576.496402724.88040-0.7895011.626809.56900HepG2RBM27
LEO1ENSG00000166477.8980.607202212.71920-1.1741019.6719017.03630HepG2RCC2
LEO1ENSG00000166477.81231.325903448.15120-1.4856028.3896027.03080HepG2NELFE
LEO1ENSG00000166477.81540.069103211.83420-1.0604013.4967012.29210HepG2RECQL
LEO1ENSG00000166477.81858.368902562.07310-0.463305.681104.75290HepG2RPLP0
LEO1ENSG00000166477.81636.245602294.02530-0.487502.875701.91450HepG2RPS10
LEO1ENSG00000166477.8828.578202218.79520-1.4211042.5874040.70350HepG2RPS19
LEO1ENSG00000166477.81161.251502513.13460-1.1138022.3960020.32540HepG2RPS2
LEO1ENSG00000166477.81284.666102316.76180-0.850708.786707.38970HepG2RPS3A
LEO1ENSG00000166477.81755.442802565.28670-0.547305.871204.29720HepG2RPS5
LEO1ENSG00000166477.81663.502402227.01710-0.420903.647902.56280HepG2SERBP1
LEO1ENSG00000166477.82328.183906830.42960-1.552807.080804.76340HepG2SF1
LEO1ENSG00000166477.82053.161503765.54200-0.875009.016807.74460HepG2SF3A3
LEO1ENSG00000166477.82966.371103522.18350-0.247801.950901.35170HepG2SF3B1
LEO1ENSG00000166477.82607.911503225.53240-0.306602.770402.17800HepG2SF3B4
LEO1ENSG00000166477.83290.270206621.32020-1.008903.112601.55750HepG2SFPQ
LEO1ENSG00000166477.81338.125802482.66370-0.8917040.4019038.46530HepG2SMN1
LEO1ENSG00000166477.82132.919203919.04540-0.877708.327506.97620HepG2SNRNP70
LEO1ENSG00000166477.82611.222203738.72560-0.5178015.3586014.42990HepG2SRFBP1
LEO1ENSG00000166477.81906.338803366.92750-0.8206011.3308010.51410HepG2SRSF1
LEO1ENSG00000166477.82435.446803154.23100-0.373106.588705.67940HepG2SRSF5
LEO1ENSG00000166477.81296.593803246.12280-1.3240073.3908071.66830HepG2SSB
LEO1ENSG00000166477.82528.559503587.08230-0.5045013.9253012.70790HepG2SUCLG1
LEO1ENSG00000166477.8985.579801687.12200-0.775507.638406.60650HepG2SUPV3L1
LEO1ENSG00000166477.81766.526503026.79730-0.776908.664207.76120HepG2TAF15
LEO1ENSG00000166477.82255.505403468.38670-0.620809.002907.80110HepG2TARDBP
LEO1ENSG00000166477.82172.341703712.19150-0.773003.131601.99710HepG2TBRG4
LEO1ENSG00000166477.8940.937202322.82820-1.3037042.7606041.23280HepG2TIAL1
LEO1ENSG00000166477.81970.969602343.69300-0.249903.317702.71240HepG2TRIM56
LEO1ENSG00000166477.81276.479601812.04320-0.505403.817101.98630HepG2TROVE2
LEO1ENSG00000166477.81949.653103121.08170-0.6788012.4184010.37160HepG2TUFM
LEO1ENSG00000166477.83018.665807102.10620-1.234304.837303.50430HepG2U2AF2
LEO1ENSG00000166477.81850.828503339.47400-0.8514011.9509010.68320HepG2UPF1
LEO1ENSG00000166477.8976.968201545.20820-0.661404.418303.13020HepG2UPF2
LEO1ENSG00000166477.8603.002003224.10960-2.4187051.9005049.82630HepG2UTP3
LEO1ENSG00000166477.83408.799902296.491500.569704.170902.61450HepG2XRCC5
LEO1ENSG00000166477.81639.984802568.53010-0.647305.184403.75800HepG2XRCC6
LEO1ENSG00000166477.8888.499601660.78290-0.9024011.174709.73600HepG2XRN2
LEO1ENSG00000166477.81740.310502340.08680-0.427209.471708.35300HepG2ZC3H8
LEO1ENSG00000166477.82925.259403672.76250-0.328303.112502.54270HepG2ZNF622
LEO1ENSG00000166477.81887.727801270.921900.5707012.0204010.92970K562AGGF1
LEO1ENSG00000166477.8990.016001375.96740-0.474904.138103.44860K562AQR
LEO1ENSG00000166477.8661.53640859.61030-0.377903.837402.69500K562BCLAF1
LEO1ENSG00000166477.8507.577801370.84440-1.4334028.8823026.25610K562BOP1
LEO1ENSG00000166477.8723.87080997.90330-0.463203.988602.43660K562CIRBP
LEO1ENSG00000166477.81482.615401772.45110-0.257602.434901.40180K562CPEB4
LEO1ENSG00000166477.8940.944601457.56740-0.631409.077507.63770K562CPSF6
LEO1ENSG00000166477.8516.32950652.14260-0.336902.368001.40140K562CSTF2
LEO1ENSG00000166477.8527.52820716.99670-0.442703.539302.34110K562DDX3X
LEO1ENSG00000166477.81583.151401834.03720-0.212202.022201.44990K562DDX47
LEO1ENSG00000166477.81984.639001423.057200.479807.171905.64820K562DKC1
LEO1ENSG00000166477.8955.898901153.08140-0.270602.444501.76140K562EIF2S2
LEO1ENSG00000166477.8982.85910749.096300.391703.125402.25540K562EIF4A3
LEO1ENSG00000166477.81083.368001483.10510-0.453104.243503.18490K562FMR1
LEO1ENSG00000166477.8923.936401257.09350-0.444203.602802.54730K562FTO
LEO1ENSG00000166477.81035.564001283.68000-0.309903.033801.83910K562GLRX3
LEO1ENSG00000166477.8991.510601391.59140-0.489005.071303.99950K562GPKOW
LEO1ENSG00000166477.8988.011001536.53360-0.637108.496307.15800K562GRSF1
LEO1ENSG00000166477.8508.014201073.25330-1.0790018.5877017.11770K562HNRNPC
LEO1ENSG00000166477.8682.99020958.32590-0.488704.387802.90850K562HNRNPF
LEO1ENSG00000166477.81860.190801403.453900.406403.302902.39360K562KIF1C
LEO1ENSG00000166477.8709.51260976.55770-0.460904.579103.36360K562MATR3
LEO1ENSG00000166477.82119.692101572.222500.430904.752203.49630K562MBNL1
LEO1ENSG00000166477.8929.713001358.35980-0.547006.373605.01760K562METAP2
LEO1ENSG00000166477.8947.964201349.61080-0.509608.630307.27670K562MTPAP
LEO1ENSG00000166477.81704.602501102.013900.629205.158603.82520K562NAA15
LEO1ENSG00000166477.81132.579001499.60190-0.405007.614306.46040K562NSUN2
LEO1ENSG00000166477.8660.52650957.42480-0.535504.171803.14900K562PCBP3
LEO1ENSG00000166477.8522.37910734.38720-0.491404.210403.21980K562POLR2G
LEO1ENSG00000166477.8978.31930742.665900.397502.888302.12330K562PRPF8
LEO1ENSG00000166477.8758.72860962.25880-0.342802.263801.45350K562PSIP1
LEO1ENSG00000166477.81774.717102171.62580-0.291202.613701.82120K562PUF60
LEO1ENSG00000166477.82880.233802309.927600.318203.580802.35680K562PUM1
LEO1ENSG00000166477.82114.847201311.514500.689209.196108.25510K562PUS1
LEO1ENSG00000166477.81751.129301277.868400.454406.392605.51690K562RBM15
LEO1ENSG00000166477.8609.67680877.81500-0.525905.095003.74580K562RCC2
LEO1ENSG00000166477.8580.98690954.73740-0.716604.278403.00060K562RPS3
LEO1ENSG00000166477.81215.021502013.23860-0.728502.786501.47970K562SFPQ
LEO1ENSG00000166477.8563.15890832.15770-0.563304.756703.30570K562SRFBP1
LEO1ENSG00000166477.81176.307301515.90500-0.365905.626804.35300K562SRPK2
LEO1ENSG00000166477.8621.99330921.88440-0.567702.924001.83230K562SRSF4
LEO1ENSG00000166477.8905.82550736.596100.298302.204301.47030K562SYNCRIP
LEO1ENSG00000166477.8744.36810943.25700-0.341602.234001.59370K562TARDBP
LEO1ENSG00000166477.8678.36250925.54670-0.448203.101002.10610K562TIAL1
LEO1ENSG00000166477.8714.87060983.13820-0.459703.869502.71450K562TRIM56
LEO1ENSG00000166477.8525.25000761.13510-0.535103.858502.63790K562UCHL5
LEO1ENSG00000166477.81310.129001590.05470-0.279403.355602.56900K562UPF1
LEO1ENSG00000166477.8957.786701360.56770-0.506406.003104.68580K562WDR3
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for LEO1 is not available on ENCORE database.





1 RBPs can affect the splicing of LEO1 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
A3SSLEO1ENSG00000166477.8chr15-5224200452242245522420045224219152244040522442050.091000.000000.00000longerK562AQR
A3SSLEO1ENSG00000166477.8chr15-5224404052244205522440405224417652245325522454600.052000.000500.00375longerK562AQR
A3SSLEO1ENSG00000166477.8chr15-5225209552252318522520955225224152252835522529300.125000.000000.00000longerK562AQR
MXELEO1ENSG00000166477.8chr15-52246677522467725225209552252318522453255224546052252835522529300.084000.001300.011451includedK562AQR

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for LEO1 is not avaliable on ENCORE database.